MCID: HPT070
MIFTS: 38

Hepatosplenic T-Cell Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Liver diseases, Rare diseases

Aliases & Classifications for Hepatosplenic T-Cell Lymphoma

MalaCards integrated aliases for Hepatosplenic T-Cell Lymphoma:

Name: Hepatosplenic T-Cell Lymphoma 58 71 32

Characteristics:

Orphanet epidemiological data:

58
hepatosplenic t-cell lymphoma
Age of onset: Adolescent,Adult;

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 32 C86.1
ICD10 via Orphanet 33 C86.1
UMLS via Orphanet 72 C1333984
Orphanet 58 ORPHA86882
UMLS 71 C1333984

Summaries for Hepatosplenic T-Cell Lymphoma

MalaCards based summary : Hepatosplenic T-Cell Lymphoma is related to lymphoma, non-hodgkin, familial and composite lymphoma. An important gene associated with Hepatosplenic T-Cell Lymphoma is ABCB1 (ATP Binding Cassette Subfamily B Member 1). The drugs Infliximab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include spleen, t cells and bone.

Wikipedia : 74 Hepatosplenic T-cell lymphoma is a rare and generally incurable form of lymphoma, except in the case of... more...

Related Diseases for Hepatosplenic T-Cell Lymphoma

Diseases related to Hepatosplenic T-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 lymphoma, non-hodgkin, familial 30.2 GZMB DPP4 CD7 ABCB1
2 composite lymphoma 30.1 TIA1 GZMB
3 t-cell adult acute lymphocytic leukemia 30.0 TIA1 CD7
4 natural killer cell leukemia 30.0 TIA1 GZMB CD7
5 acute leukemia 29.9 SETD2 CD7 ABCB1
6 t-cell lymphoma, subcutaneous panniculitis-like 29.8 TIA1 GZMB CD7
7 angioimmunoblastic t-cell lymphoma 29.4 TIA1 GZMB
8 lymphoma 11.0
9 crohn's disease 10.7
10 peripheral t-cell lymphoma 10.7
11 splenomegaly 10.6
12 inflammatory bowel disease 10.6
13 lymphoma, hodgkin, classic 10.5
14 pancytopenia 10.5
15 thrombocytopenia 10.5
16 lymphocytic leukemia 10.4
17 crohn's colitis 10.4
18 chromosomal triplication 10.4
19 lymphoproliferative syndrome 10.3
20 leukemia 10.3
21 t-cell leukemia 10.3
22 spondyloarthropathy 1 10.2
23 inflammatory bowel disease 6 10.2
24 myelodysplastic syndrome 10.2
25 exanthem 10.2
26 inflammatory spondylopathy 10.2
27 glomerulonephritis 10.2
28 pustulosis of palm and sole 10.2
29 hemolytic anemia 10.2
30 spondylitis 10.2
31 psoriasis 10.2
32 47,xyy 10.2
33 enteropathy-associated t-cell lymphoma 10.2
34 ring chromosome 7 10.2
35 ring chromosome 10.2
36 pfeiffer syndrome 10.1
37 systemic lupus erythematosus 10.1
38 schistosoma mansoni infection, susceptibility/ 10.1
39 anemia, autoimmune hemolytic 10.1
40 immune deficiency disease 10.1
41 myelofibrosis 10.1
42 leukemia, acute myeloid 10.1
43 neuropathy, congenital hypomyelinating, 2 10.1
44 hemophagocytic lymphohistiocytosis 10.1
45 adult t-cell leukemia 10.1
46 anaplastic large cell lymphoma 10.1
47 t-cell large granular lymphocyte leukemia 10.1
48 disseminated intravascular coagulation 10.1
49 common variable immunodeficiency 10.1
50 neutropenia 10.1

Graphical network of the top 20 diseases related to Hepatosplenic T-Cell Lymphoma:



Diseases related to Hepatosplenic T-Cell Lymphoma

Symptoms & Phenotypes for Hepatosplenic T-Cell Lymphoma

Drugs & Therapeutics for Hepatosplenic T-Cell Lymphoma

Drugs for Hepatosplenic T-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4 170277-31-3
2 Antirheumatic Agents Phase 4
3 Gastrointestinal Agents Phase 4
4 Dermatologic Agents Phase 4
5
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
6
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
7
Methylcobalamin Approved, Investigational Phase 1, Phase 2 13422-55-4
8
Hydroxocobalamin Approved Phase 1, Phase 2 13422-51-0 11953898 15589840
9
Lenalidomide Approved Phase 2 191732-72-6 216326
10
Denosumab Approved Phase 1, Phase 2 615258-40-7
11
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
12
Cyanocobalamin Approved, Nutraceutical Phase 1, Phase 2 68-19-9 44176380
13
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
14
tipifarnib Investigational Phase 2 192185-72-1 159324
15
Cobalamin Experimental Phase 1, Phase 2 13408-78-1 6857388
16 10-deazaaminopterin Phase 1, Phase 2
17 Immunosuppressive Agents Phase 1, Phase 2
18 Folic Acid Antagonists Phase 1, Phase 2
19 Trace Elements Phase 1, Phase 2
20 Vitamins Phase 1, Phase 2
21 Vitamin B 12 Phase 1, Phase 2
22 Micronutrients Phase 1, Phase 2
23 Nutrients Phase 1, Phase 2
24 Vitamin B Complex Phase 1, Phase 2
25 Vitamin B9 Phase 1, Phase 2
26 Vitamin B12 Phase 1, Phase 2
27 Immunologic Factors Phase 1, Phase 2
28 Anti-Infective Agents Phase 1, Phase 2
29 Folate Phase 1, Phase 2
30 Antimetabolites Phase 1, Phase 2
31 Hematinics Phase 1, Phase 2
32 Antiviral Agents Phase 1, Phase 2
33 Angiogenesis Inhibitors Phase 2
34 Antibodies, Monoclonal Phase 1, Phase 2
35 Antibodies Phase 1, Phase 2
36 Immunoglobulins Phase 1, Phase 2
37 Protein Kinase Inhibitors Phase 1, Phase 2
38
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
39
Bortezomib Approved, Investigational Phase 1 179324-69-7 93860 387447
40
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
41
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
42
Imetelstat Investigational Phase 1 868169-64-6
43 Antibiotics, Antitubercular Phase 1
44 Anti-Bacterial Agents Phase 1
45 Vitamin B3 Phase 1
46
Motesanib diphosphate Phase 1 850649-62-6 11450633
47 Nicotinic Acids Phase 1
48
Methotrexate Approved 59-05-2, 1959-05-2 126941
49
Etanercept Approved, Investigational 185243-69-0
50 Liver Extracts

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Research Study to Bank Samples for Future Evaluation to Identify Biomarkers That Predispose Crohn's Disease and Ulcerative Colitis Patients to Develop Hepatosplenic T-Cell Lymphoma (HSTCL) Recruiting NCT01804166 Phase 4 Infliximab;Golimumab
2 An Open Label Phase II Study of Tipifarnib in Subjects With Relapsed or Refractory Peripheral T-Cell Lymphoma Unknown status NCT02464228 Phase 2 Tipifarnib
3 A Phase 1/2a Open-label Study of Pralatrexate and Gemcitabine With Vitamin B12 and Folic Acid Supplementation in Patients With Relapsed or Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
4 A Phase II Clinical Trial of Lenalidomide for T-cell Non-Hodgkin's Lymphoma Completed NCT00322985 Phase 2 Lenalidomide
5 Denosumab (A Monoclonal Antibody to Receptor Activator of Nuclear Factor-Kappa B Ligand (RANKL) in Crohn's Disease Completed NCT02321280 Phase 1, Phase 2 Denosumab
6 Phase I/II Study of Dasatinib in Recipients of Autologous Stem Cell Transplantation for Hematologic Malignancies. Active, not recruiting NCT01609816 Phase 1, Phase 2 Dasatinib
7 Phase I/II Study of Dasatinib in Recipients of Allogeneic Stem Cell Transplantation for Hematologic Malignancies. Active, not recruiting NCT01643603 Phase 1, Phase 2 Dasatinib
8 The Safety and Tolerability of Intravitreal Infliximab (Remicade) in Patients With Refractory Diabetic Macular Edema or Choroidal Neovascularization Secondary to Age Related Macular Degeneration- A Pilot Study Unknown status NCT00695682 Phase 1 intravitreal injection of infliximab
9 Phase I Study of Bortezomib and Romidepsin in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Indolent B-Cell Lymphoma, Peripheral T-Cell Lymphoma or Cutaneous T-Cell Lymphoma Completed NCT00963274 Phase 1 Bortezomib;Romidepsin
10 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium
11 Partially HLA-Matched Irradiated Allogeneic Cellular Therapy After Reduced Intensity Total Body Irradiation Terminated NCT00996359 Phase 1
12 A Retrospective Review of Reports of Hepatosplenic T-cell Lymphoma in the Dutch National Database of Pathology (Pathologisch-Anatomisch Landelijk Geautomatiseerd Archief [PALGA]), a Database of Pathology Results for The Netherlands Completed NCT00731536
13 Dose Effect Relationship of Methotrexate and Hepatic Fibrosis in Patients With Inflammatory Bowel Disease Completed NCT03531593
14 An Observational, Prospective, Cohort Study to Evaluate Safety and Efficacy of Remsima™ in Patients With Ankylosing Spondylitis Recruiting NCT02557308
15 An Observational, Prospective Cohort Study to Evaluate Safety and Efficacy of Remsima™ in Patients With Rheumatoid Arthritis Recruiting NCT02557295
16 A Multicenter Study to Collect Samples for Future Evaluation of Biomarkers and Genetic Mutations in Patients Exposed to Adalimumab With Crohn's Disease (CD) or Ulcerative Colitis (UC) Who Developed Hepatosplenic T-Cell Lymphoma (HSTCL) Withdrawn NCT02087878

Search NIH Clinical Center for Hepatosplenic T-Cell Lymphoma

Genetic Tests for Hepatosplenic T-Cell Lymphoma

Anatomical Context for Hepatosplenic T-Cell Lymphoma

MalaCards organs/tissues related to Hepatosplenic T-Cell Lymphoma:

40
Spleen, T Cells, Bone, Liver, Bone Marrow, B Cells, Nk Cells

Publications for Hepatosplenic T-Cell Lymphoma

Articles related to Hepatosplenic T-Cell Lymphoma:

(show top 50) (show all 253)
# Title Authors PMID Year
1
Hepatosplenic T-Cell Lymphoma Arising in a Patient Treated With Tumor Necrosis Factor-α Inhibitors for Ankylosing Spondylitis. 61
31764502 2019
2
Causes of double-negative T-cell lymphocytosis in children and adults. 61
31810993 2019
3
Hepatosplenic T-Cell Lymphoma in an Immunocompetent Male with Central Nervous System Invasion: A Rare Clinical Entity. 61
30500103 2019
4
A Skin Plaque Preceding Systemic Relapse of Gamma-Delta Hepatosplenic T-Cell Lymphoma. 61
31725483 2019
5
Tetrasomy 8 and isochromosome 7q in CD5-positive hepatosplenic T-cell lymphoma with leukemic presentation. 61
31342408 2019
6
Incidence and outcomes of rare T cell lymphomas from the T Cell Project: hepatosplenic, enteropathy associated and peripheral gamma delta T cell lymphomas. 61
31709579 2019
7
Complete Spontaneous Regression of Hepatosplenic T-Cell Lymphoma After Surgical Biopsy. 61
31652159 2019
8
Refractory α/β-Hepatosplenic T-cell Lymphoma With Secondary CNS Dissemination and Severe Morbidity Related to Intrathecal Chemotherapy: A Case Report and Literature Review. 61
31362868 2019
9
Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn's Disease. 61
31328143 2019
10
Hepatosplenic αβ T-Cell Lymphoma as Second Malignancy in Young Adult Patient With Previously Undiagnosed Ataxia-Telangiectasia. 61
31259827 2019
11
Deregulated expression of NKL homeobox genes in T-cell lymphomas. 61
31143370 2019
12
Development of Leiomyosarcoma in a Patient Treated with Azathioprine. 61
31454474 2019
13
Hepatosplenic T cell lymphoma presenting as multiorgan failure. 61
30902844 2019
14
DNA methylation profiling of hepatosplenic T-cell lymphoma. 61
30337361 2019
15
Successful Bridging Chemotherapy with Gemcitabine, Carboplatin, and Dexamethasone before Unrelated Stem Cell Transplantation for Hepatosplenic T-cell Lymphoma. 61
30449784 2019
16
The Impact of Inflammatory Bowel Disease in Canada 2018: Children and Adolescents with IBD. 61
31294385 2019
17
Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders with a T- or NK-cell phenotype. 61
31257346 2019
18
[Acute HIV infection pathologically mimicking T-cell lymphoma]. 61
31391369 2019
19
An unusual presentation of an uncommon lymphoma, hepatosplenic T-cell lymphoma. 61
30956608 2019
20
Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges. 61
31346479 2019
21
Hepatosplenic T-Cell Lymphomas. 61
30596219 2019
22
Collapsing glomerulonephritis with podocyte markers in hemophagocytic syndrome secondary to hepatosplenic T-cell lymphoma 61
30653858 2018
23
Clinicopathological features of splenic tumours of lymphoid tissue. 61
30087035 2018
24
A rare case of hepatosplenic γδ T-cell lymphoma expressing CD19 with ring chromosome 7 and trisomy 8. 61
30553467 2018
25
Successful second allogeneic stem-cell transplantation from the same sibling donor for a patient with recurrent hepatosplenic gamma-delta (γ/δ) T-cell lymphoma: A case report. 61
30383643 2018
26
Hepatosplenic γδ T Cell Lymphoma Involving the Brain. 61
30030187 2018
27
Hepatosplenic T cell lymphoma: a unifying entity in a patient with hemolytic anemia, massive splenomegaly, and liver dysfunction. 61
29766398 2018
28
Malignancy and mortality in paediatric-onset inflammatory bowel disease: a 3-year prospective, multinational study from the paediatric IBD Porto group of ESPGHAN. 61
29984520 2018
29
Peripheral T-Cell Lymphomas: Incorporating New Developments in Diagnostics, Prognostication, and Treatment Into Clinical Practice-PART 2: ENKTL, EATL, Indolent T-Cell LDP of the GI Tract, ATLL, and Hepatosplenic T-Cell Lymphoma. 61
30153323 2018
30
Therapeutic role of methotrexate in pediatric Crohn's disease. 61
29338679 2018
31
Peripheral T-Cell Lymphomas: Incorporating New Developments in Diagnostics, Prognostication, and Treatment Into Clinical Practice-PART 1: PTCL-NOS, FTCL, AITL, ALCL. 61
30080923 2018
32
Hepatosplenic T-Cell Lymphoma Arising in a Patient Treated With Tumor Necrosis Factor-α Inhibitors for Ankylosing Spondylitis. 61
29933321 2018
33
[Incidence of Bone Marrow Involvement in Different Pathological Type Lymphoma Patients]. 61
29950217 2018
34
Peripheral T cell lymphoma: Clinico-pathological characteristics & outcome from a tertiary care centre in south India. 61
30082570 2018
35
Expect the unexpected - Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener. 61
29676377 2018
36
Hepatosplenic T-cell Lymphoma: a review of clinicopathologic features, pathogenesis, and prognostic factors. 61
29337025 2018
37
Leukemic conversion of hepatosplenic T-cell lymphoma with pleomorphic morphology and an aggressive course. 61
29676383 2018
38
Intrasinusoidal pattern of bone marrow infiltration by hepatosplenic T-cell lymphoma. 61
29636955 2018
39
Loss of CD3 and TCRγδ expression in a relapsed hepatosplenic T-cell lymphoma. 61
28573906 2018
40
Spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis: a European registries collaborative project. 61
28822981 2017
41
[Tumors of lymphoid and hematopoietic tissue of spleen: a clinicopathologic analysis of 53 cases]. 61
29136691 2017
42
Hepatosplenic T-cell lymphoma associated with membranoproliferative glomerulonephritis. 61
28351190 2017
43
Hepatosplenic Gamma Delta T-Cell Lymphoma (HSGDTCL): Two Rare Case Reports from Western India. 61
29340126 2017
44
Florid splenic γ/δ T-cell proliferation in patients with splenomegaly and cytopenias: a "high stakes" diagnostic challenge. 61
28235627 2017
45
Leukemic phase of hepatosplenic T-cell lymphoma: A great masquerader of acute leukemia. 61
28937394 2017
46
Incidence, clinical findings, and survival of hepatosplenic T-cell lymphoma in the United States. 61
28263402 2017
47
It Takes a Village to Unmask HSTL. 61
28373165 2017
48
The Genetic Basis of Hepatosplenic T-cell Lymphoma. 61
28122867 2017
49
A Case of Hepatosplentic T Cell Lymphoma - A Rare, Aggressive Tumor of the Young. 61
28414669 2017
50
Hepatosplenic T-cell lymphoma arising in patients with immunodysregulatory disorders: a study of 7 patients who did not receive tumor necrosis factor-α inhibitor therapy and literature review. 61
28038706 2017

Variations for Hepatosplenic T-Cell Lymphoma

Expression for Hepatosplenic T-Cell Lymphoma

LifeMap Discovery
Genes differentially expressed in tissues of Hepatosplenic T-Cell Lymphoma patients vs. healthy controls: 35 (show top 50) (show all 400)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 TMEM178A transmembrane protein 178A Spleen + 9.71 0.000
2 LPAR3 lysophosphatidic acid receptor 3 Spleen + 8.91 0.000
3 SOX2 SRY (sex determining region Y)-box 2 Spleen + 8.60 0.000
4 MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 Spleen + 7.68 0.001
5 CLEC3B C-type lectin domain family 3, member B Spleen - 7.16 0.001
6 KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 Spleen + 7.16 0.000
7 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 Spleen - 7.01 0.023
8 KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 Spleen + 6.95 0.000
9 KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 Spleen + 6.85 0.001
10 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 Spleen + 6.83 0.000
11 KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 Spleen + 6.66 0.000
12 KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 Spleen + 6.63 0.001
13 MARCO macrophage receptor with collagenous structure Spleen + 6.61 0.009
14 KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 Spleen + 6.34 0.001
15 CXCL13 chemokine (C-X-C motif) ligand 13 Spleen - 6.26 0.004
16 OLFML2A olfactomedin-like 2A Spleen - 6.25 0.015
17 KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 Spleen + 6.21 0.002
18 KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 Spleen + 6.14 0.000
19 KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 Spleen + 6.13 0.001
20 GREB1 growth regulation by estrogen in breast cancer 1 Spleen + 6.09 0.001
21 KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 Spleen + 6.02 0.002
22 LOC100505501 uncharacterized LOC100505501 Spleen + 5.96 0.000
23 MAATS1 MYCBP-associated, testis expressed 1 Spleen - 5.93 0.000
24 TRGV5 T cell receptor gamma variable 5 Spleen + 5.90 0.000
25 CRHBP corticotropin releasing hormone binding protein Spleen - 5.89 0.000
26 KLRC3 killer cell lectin-like receptor subfamily C, member 3 Spleen + 5.87 0.000
27 SMIM24 small integral membrane protein 24 Spleen + 5.85 0.000
28 CCM2L cerebral cavernous malformation 2-like Spleen - 5.83 0.005
29 RUNDC3B RUN domain containing 3B Spleen + 5.82 0.000
30 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 Spleen + 5.80 0.000
31 PCDH7 protocadherin 7 Spleen - 5.78 0.010
32 APLNR apelin receptor Spleen - 5.76 0.000
33 KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A Spleen + 5.73 0.001
34 KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 Spleen + 5.69 0.001
35 GIPC2 GIPC PDZ domain containing family, member 2 Spleen - 5.69 0.000
36 GTSF1 gametocyte specific factor 1 Spleen + 5.62 0.001
37 GPM6A glycoprotein M6A Spleen - 5.62 0.000
38 IGFBP3 insulin-like growth factor binding protein 3 Spleen - 5.61 0.004
39 BMP7 bone morphogenetic protein 7 Spleen + 5.59 0.000
40 PDE2A phosphodiesterase 2A, cGMP-stimulated Spleen - 5.58 0.002
41 KIF14 kinesin family member 14 Spleen + 5.55 0.000
42 HYAL1 hyaluronoglucosaminidase 1 Spleen - 5.51 0.006
43 GPR82 G protein-coupled receptor 82 Spleen + 5.49 0.000
44 DNASE1L3 deoxyribonuclease I-like 3 Spleen - 5.44 0.003
45 USP44 ubiquitin specific peptidase 44 Spleen + 5.44 0.000
46 CD96 CD96 molecule Spleen + 5.42 0.001
47 AKAP5 A kinase (PRKA) anchor protein 5 Spleen + 5.41 0.000
48 RNASE1 ribonuclease, RNase A family, 1 (pancreatic) Spleen - 5.40 0.008
49 PLVAP plasmalemma vesicle associated protein Spleen - 5.38 0.001
50 NEK2 NIMA-related kinase 2 Spleen + 5.35 0.000
Search GEO for disease gene expression data for Hepatosplenic T-Cell Lymphoma.

Pathways for Hepatosplenic T-Cell Lymphoma

GO Terms for Hepatosplenic T-Cell Lymphoma

Biological processes related to Hepatosplenic T-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 8.8 PIK3CD DPP4 CD7

Molecular functions related to Hepatosplenic T-Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alpha-tubulin binding GO:0043014 8.62 SETD2 INO80

Sources for Hepatosplenic T-Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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