MCID: HPT070
MIFTS: 35

Hepatosplenic T-Cell Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Liver diseases, Rare diseases

Aliases & Classifications for Hepatosplenic T-Cell Lymphoma

MalaCards integrated aliases for Hepatosplenic T-Cell Lymphoma:

Name: Hepatosplenic T-Cell Lymphoma 60 74

Characteristics:

Orphanet epidemiological data:

60
hepatosplenic t-cell lymphoma
Age of onset: Adolescent,Adult;

Classifications:



External Ids:

ICD10 34 C86.1
ICD10 via Orphanet 35 C86.1
UMLS via Orphanet 75 C1333984
Orphanet 60 ORPHA86882
UMLS 74 C1333984

Summaries for Hepatosplenic T-Cell Lymphoma

MalaCards based summary : Hepatosplenic T-Cell Lymphoma is related to lymphoma and crohn's disease. An important gene associated with Hepatosplenic T-Cell Lymphoma is ABCB1 (ATP Binding Cassette Subfamily B Member 1). Affiliated tissues include spleen, t cells and bone.

Wikipedia : 77 Hepatosplenic T-cell lymphoma is a rare and generally incurable form of lymphoma, except in the case of... more...

Related Diseases for Hepatosplenic T-Cell Lymphoma

Diseases related to Hepatosplenic T-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 58, show less)
# Related Disease Score Top Affiliating Genes
1 lymphoma 11.1
2 crohn's disease 10.6
3 leukemia 10.6
4 inflammatory bowel disease 10.4
5 lymphocytic leukemia 10.4
6 acute leukemia 10.3
7 hemolytic anemia 10.2
8 hepatitis 10.2
9 thrombocytopenia 10.2
10 crohn's colitis 10.2
11 helsmoortel-van der aa syndrome 10.1 ABCB1 CD7
12 spondyloarthropathy 1 10.1
13 systemic lupus erythematosus 10.1
14 myelofibrosis 10.1
15 leukemia, acute myeloid 10.1
16 myelodysplastic syndrome 10.1
17 autoimmune lymphoproliferative syndrome, type v 10.1
18 deficiency anemia 10.1
19 autoimmune hepatitis 10.1
20 common variable immunodeficiency 10.1
21 glomerulonephritis 10.1
22 hematopoietic stem cell transplantation 10.1
23 hemophagocytic lymphohistiocytosis 10.1
24 hepatitis b 10.1
25 schistosomiasis 10.1
26 membranoproliferative glomerulonephritis 10.1
27 purpura 10.1
28 progressive multifocal leukoencephalopathy 10.1
29 spondylitis 10.1
30 t-cell leukemia 10.1
31 myeloid leukemia 10.1
32 lupus erythematosus 10.1
33 ring chromosome 7 10.1
34 splenomegaly 10.1
35 orbit lymphoma 10.0 GZMB TIA1
36 lichen sclerosus et atrophicus 10.0 GZMB TIA1
37 lymphomatoid granulomatosis 10.0 GZMB TIA1
38 viral esophagitis 10.0 GZMB TIA1
39 lymphocytic gastritis 10.0 GZMB TIA1
40 panniculitis 10.0 GZMB TIA1
41 primary cutaneous anaplastic large cell lymphoma 10.0 GZMB TIA1
42 composite lymphoma 10.0 GZMB TIA1
43 natural killer cell leukemia 10.0 GZMB TIA1
44 lymphomatoid papulosis 10.0 GZMB TIA1
45 choriocarcinoma of the testis 9.9 GZMB TIA1
46 sezary's disease 9.9 CD7 DPP4
47 giardiasis 9.9 GZMB TIA1
48 infiltrating lipoma 9.9 GZMB TIA1
49 necrotizing sialometaplasia 9.9 GZMB TIA1
50 lymphoma, non-hodgkin, familial 9.9 ABCB1 CD7 GZMB
51 ileum cancer 9.9 GZMB TIA1
52 angioimmunoblastic t-cell lymphoma 9.9 GZMB TIA1
53 reticulosarcoma 9.8 GZMB TIA1
54 t-cell adult acute lymphocytic leukemia 9.8 CD7 TIA1
55 b-cell expansion with nfkb and t-cell anergy 9.8 GZMB TIA1
56 peripheral t-cell lymphoma 9.7 GZMB TIA1
57 cutaneous t cell lymphoma 9.6 GZMB TIA1
58 mycosis fungoides 9.5 CD7 DPP4 GZMB TIA1

Graphical network of the top 20 diseases related to Hepatosplenic T-Cell Lymphoma:



Diseases related to Hepatosplenic T-Cell Lymphoma

Symptoms & Phenotypes for Hepatosplenic T-Cell Lymphoma

Drugs & Therapeutics for Hepatosplenic T-Cell Lymphoma

Search Clinical Trials , NIH Clinical Center for Hepatosplenic T-Cell Lymphoma

Genetic Tests for Hepatosplenic T-Cell Lymphoma

Anatomical Context for Hepatosplenic T-Cell Lymphoma

MalaCards organs/tissues related to Hepatosplenic T-Cell Lymphoma:

42
Spleen, T Cells, Bone, Liver, Bone Marrow, B Cells, Myeloid

Publications for Hepatosplenic T-Cell Lymphoma

Articles related to Hepatosplenic T-Cell Lymphoma:

(showing 121, show less)
# Title Authors Year
1
DNA methylation profiling of hepatosplenic T-cell lymphoma. ( 30337361 )
2019
2
Successful Bridging Chemotherapy with Gemcitabine, Carboplatin, and Dexamethasone before Unrelated Stem Cell Transplantation for Hepatosplenic T-cell Lymphoma. ( 30449784 )
2019
3
Hepatosplenic T cell lymphoma presenting as multiorgan failure. ( 30902844 )
2019
4
An unusual presentation of an uncommon lymphoma, hepatosplenic T-cell lymphoma. ( 30956608 )
2019
5
Hepatosplenic T cell lymphoma: a unifying entity in a patient with hemolytic anemia, massive splenomegaly, and liver dysfunction. ( 29766398 )
2018
6
Loss of CD3 and TCRγδ expression in a relapsed hepatosplenic T-cell lymphoma. ( 28573906 )
2018
7
Hepatosplenic T-cell Lymphoma: a review of clinicopathologic features, pathogenesis, and prognostic factors. ( 29337025 )
2018
8
Intrasinusoidal pattern of bone marrow infiltration by hepatosplenic T-cell lymphoma. ( 29636955 )
2018
9
Expect the unexpected - Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener. ( 29676377 )
2018
10
Leukemic conversion of hepatosplenic T-cell lymphoma with pleomorphic morphology and an aggressive course. ( 29676383 )
2018
11
Hepatosplenic T-Cell Lymphoma Arising in a Patient Treated With Tumor Necrosis Factor-α Inhibitors for Ankylosing Spondylitis. ( 29933321 )
2018
12
Peripheral T-Cell Lymphomas: Incorporating New Developments in Diagnostics, Prognostication, and Treatment Into Clinical Practice-PART 2: ENKTL, EATL, Indolent T-Cell LDP of the GI Tract, ATLL, and Hepatosplenic T-Cell Lymphoma. ( 30153323 )
2018
13
Hepatosplenic T-Cell Lymphoma in an Immunocompetent Male with Central Nervous System Invasion: A Rare Clinical Entity. ( 30500103 )
2018
14
Leukemic phase of hepatosplenic T-cell lymphoma: A great masquerader of acute leukemia. ( 28937394 )
2017
15
Hepatosplenic T-cell lymphoma associated with membranoproliferative glomerulonephritis. ( 28351190 )
2017
16
Distinguishing Between Hepatosplenic T-cell Lymphoma and γδ T-cell Large Granular Lymphocytic Leukemia: A Clinicopathologic, Immunophenotypic, and Molecular Analysis. ( 27755009 )
2017
17
Hepatosplenic T-cell lymphoma arising in patients with immunodysregulatory disorders: a study of 7 patients who did not receive tumor necrosis factor-α inhibitor therapy and literature review. ( 28038706 )
2017
18
The Genetic Basis of Hepatosplenic T-cell Lymphoma. ( 28122867 )
2017
19
Incidence, clinical findings, and survival of hepatosplenic T-cell lymphoma in the United States. ( 28263402 )
2017
20
Hepatosplenic T-cell lymphoma: an acute leukemia presentation. ( 27158719 )
2016
21
Hepatosplenic T-cell lymphoma: an acute leukemia presentation ( 28845955 )
2016
22
Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis. ( 27516526 )
2016
23
Hepatosplenic T-cell lymphoma in a 47-year-old Crohn's disease patient on thiopurine monotherapy. ( 28058028 )
2016
24
Hepatosplenic T-cell lymphoma with coexistent hepatitis B infection: a rare clinicopathologic entity. ( 26481866 )
2016
25
Hepatosplenic T-Cell Lymphoma Mimicking Acute Myeloid Leukemia. ( 26708981 )
2016
26
Four hepatosplenic T-cell lymphoma cases of Japanese patients. ( 26870659 )
2016
27
Prognostic Factors of Hepatosplenic T-cell Lymphoma: Clinicopathologic Study of 28 Cases. ( 26872013 )
2016
28
Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome: analysis of 25 patients. ( 26997444 )
2016
29
Hepatosplenic T-cell lymphoma in a young immunocompetent man. ( 27033291 )
2016
30
Cutaneous presentation of hepatosplenic T-cell lymphoma-a potential mimicker of primary cutaneous gamma-delta T-cell lymphoma. ( 27562705 )
2016
31
Hepatosplenic T Cell Lymphoma in an Immunocompetent Female Diagnosed using Flow Cytometry: A Rare Clinical Entity. ( 27656456 )
2016
32
Hepatosplenic T-cell lymphoma with blastoid morphology in a patient with Crohn disease. ( 27811192 )
2016
33
Successful treatment with reduced-intensity cord blood transplant in a patient with relapsed refractory hepatosplenic T-cell lymphoma. ( 25065703 )
2015
34
Allogeneic and autologous stem cell transplantation for hepatosplenic T-cell lymphoma: a retrospective study of the EBMT Lymphoma Working Party. ( 25234166 )
2015
35
Hepatosplenic T-cell lymphoma: A case series. ( 25450840 )
2015
36
Outcomes of allogeneic stem cell transplantation in hepatosplenic T-cell lymphoma. ( 26047388 )
2015
37
Childhood Hepatosplenic T-cell Lymphoma with Skin Involvement. ( 26061932 )
2015
38
Hepatosplenic T-cell lymphoma with aberrant expression of serum β-HCG: a case report. ( 26108251 )
2015
39
Gastroenterology: Hepatosplenic T cell lymphoma associated with schistosomiasis. ( 26211690 )
2015
40
Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review With an Emphasis on Diagnostic Differentiation From Other T-Cell/Natural Killer-Cell Neoplasms. ( 26317456 )
2015
41
Hepatosplenic T-cell lymphoma mimicking bone marrow metastasis. ( 26788568 )
2015
42
Hepatosplenic T-Cell Lymphoma: A Population-Based Study Assessing Incidence and Association With Immune-Mediated Disease. ( 27099586 )
2015
43
Hemophagocytic lymphohistiocytosis associated with hepatosplenic T-cell lymphoma: case report. ( 28573125 )
2014
44
Lymphoma with features intermediate between aggressive T-large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma: a diagnostic dilemma? ( 24524924 )
2014
45
Coexistent hairy cell leukaemia and hepatosplenic T-cell lymphoma: a case report. ( 24621139 )
2014
46
Hepatosplenic T-cell lymphoma, immunosuppressive agents and biologicals: what are the risks? ( 24621284 )
2014
47
Purpura of the face and neck: an atypical clinical presentation revealing a hepatosplenic T cell lymphoma. ( 24707248 )
2014
48
Simultaneous hepatosplenic T-cell lymphoma and myelofibrosis. ( 24761381 )
2014
49
De novo CD3 negative hepatosplenic T-cell lymphoma: diagnostic challenges and pitfalls. ( 24978925 )
2014
50
Hepatosplenic T-cell lymphoma: a rare cause of hepatosplenomegaly. ( 25012882 )
2014
51
Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma. ( 25057852 )
2014
52
Hepatosplenic T-cell lymphoma. ( 25221804 )
2014
53
Hepatosplenic T cell lymphoma: a rare case report. ( 25332523 )
2014
54
Hepatosplenic T cell lymphoma. ( 25332524 )
2014
55
Intensive induction chemotherapy followed by early high-dose therapy and hematopoietic stem cell transplantation results in improved outcome for patients with hepatosplenic T-cell lymphoma: a single institution experience. ( 23107915 )
2013
56
Successful treatment of hepatosplenic T-cell lymphoma with ESHAP followed by autologous stem cell transplant. ( 23598914 )
2013
57
Hepatosplenic T-cell lymphoma: is cure possible? ( 23598915 )
2013
58
CD4(-)/CD8(-) variant of T-cell large granular lymphocytic leukemia or hepatosplenic T-cell lymphoma: a clinicopathologic dilemma. ( 23800602 )
2013
59
Use of case reports and the Adverse Event Reporting System in systematic reviews: overcoming barriers to assess the link between Crohn's disease medications and hepatosplenic T-cell lymphoma. ( 23826928 )
2013
60
Hepatosplenic T-cell lymphoma. ( 24033076 )
2013
61
Hepatosplenic T-cell lymphoma appearing in the peripheral blood. ( 24137640 )
2013
62
Histopathological, immunophenotypic and clinical particularities and evolution of a case of hepatosplenic T-cell lymphoma in transformation to leukemia. ( 24399013 )
2013
63
F-18 Fluorodeoxyglucose non-avid hepatosplenic T cell lymphoma: a diagnostic pitfall. ( 21584668 )
2012
64
The incidence of hepatosplenic T-cell lymphoma in a large managed care organization, with reference to anti-tumor necrosis factor therapy, Northern California, 2000-2006. ( 21823196 )
2012
65
Clinicopathological features of hepatosplenic T cell lymphoma: a single centre experience from India. ( 21916832 )
2012
66
Hematologic features of hepatosplenic T-cell lymphoma. ( 22261460 )
2012
67
Differential diagnosis of CD4-/CD8- γδ T-cell large granular lymphocytic leukemia and hepatosplenic T-cell lymphoma. ( 22338065 )
2012
68
Molecular features of hepatosplenic T-cell lymphoma unravels potential novel therapeutic targets. ( 22510872 )
2012
69
F-18 flourodeoxyglucose positron emission tomography/computed tomography findings in a case of hepatosplenic T-cell lymphoma. ( 22531524 )
2012
70
Common variable immunodeficiency associated with hepatosplenic T-cell lymphoma mimicking juvenile systemic lupus erythematosus. ( 21776287 )
2011
71
Cytogenetic and molecular characterization of a hepatosplenic T-cell lymphoma: report of a novel chromosomal aberration. ( 21504708 )
2011
72
Hepatosplenic T-cell lymphoma: clinicopathologic, immunophenotypic, and molecular characterization of 17 Chinese cases. ( 21683978 )
2011
73
Relapsed hepatosplenic T-cell lymphoma heralded by a solitary skin nodule. ( 21752051 )
2011
74
Hepatosplenic T-cell lymphoma is a distinct rare entity: diagnosis by fine-needle aspiration cytology. ( 21837655 )
2011
75
Hepatosplenic T-cell lymphoma in patients receiving TNF-α inhibitor therapy: expanding the groups at risk. ( 21941193 )
2011
76
Hepatosplenic T-cell lymphoma. ( 22379294 )
2011
77
A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease. ( 20888436 )
2011
78
Hepatosplenic T-cell lymphoma in inflammatory bowel disease: a possible thiopurine-induced chromosomal abnormality. ( 20927075 )
2010
79
Hepatosplenic T-cell lymphoma and inflammatory bowel disease. ( 21122554 )
2010
80
Hepatosplenic T-cell lymphoma in a young man with Crohn's disease: case report and literature review. ( 20371449 )
2010
81
Hepatosplenic T cell lymphoma responsive to 2'-deoxycoformycin therapy. ( 20652973 )
2010
82
A seventeen-year-old female with hepatosplenic T-cell lymphoma associated with parvoviral infection. ( 21589836 )
2010
83
Hepatosplenic T-cell lymphoma and TNF-α inhibitors. ( 21082951 )
2009
84
Crohn's disease, hepatosplenic T-cell lymphoma and no biological therapy: are we barking up the wrong tree? ( 19067412 )
2009
85
Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease: update. ( 19274799 )
2009
86
Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease. ( 19296822 )
2009
87
Importance of early splenectomy in patients with hepatosplenic T-cell lymphoma and severe thrombocytopenia. ( 19408055 )
2009
88
Sustained first remission in an adolescent with hepatosplenic T-cell lymphoma treated with T-cell leukemia induction, nucleoside analog-based consolidation, and early hematopoietic stem cell transplant. ( 19479793 )
2009
89
Hepatosplenic T-cell lymphoma in a patient with Crohn's disease. ( 19575026 )
2009
90
Post-transplant hepatosplenic T-cell lymphoma successfully treated with HyperCVAD regimen. ( 17876769 )
2008
91
Long-term survival in two patients with hepatosplenic T cell lymphoma treated with interferon-alpha. ( 18452073 )
2008
92
Hepatosplenic T cell lymphoma in inflammatory bowel disease. ( 18667489 )
2008
93
Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease. ( 18928444 )
2008
94
[Clinicopathologic study of hepatosplenic T-cell lymphoma]. ( 18677385 )
2008
95
Infliximab use and hepatosplenic T cell lymphoma: questions to be asked and lessons learned. ( 17255825 )
2007
96
Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. ( 17255842 )
2007
97
Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale? ( 17480018 )
2007
98
Hepatosplenic T-cell lymphoma in a patient with Crohn's disease who received infliximab therapy. ( 17613771 )
2007
99
Gamma-delta hepatosplenic T-cell lymphoma. Description of a case with immunophenotypic and molecular follow-up successfully treated with chemotherapy alone. ( 16321867 )
2006
100
Progressive multifocal leukoencephalopathy in a patient with hepatosplenic T cell lymphoma. ( 16479120 )
2006
101
NK-cell-associated receptor expression in hepatosplenic T-cell lymphoma, insights into pathogenesis. ( 16525496 )
2006
102
Ring chromosome 7 with amplification of 7q sequences in a pediatric case of hepatosplenic T-cell lymphoma. ( 16737917 )
2006
103
Hepatosplenic T-cell lymphoma in an adolescent patient after immunomodulator and biologic therapy for Crohn disease. ( 15699701 )
2005
104
Morphologic, immunohistochemical, and molecular characterization of hepatosplenic T-cell lymphoma in a dog. ( 15195270 )
2004
105
Case report: a common presentation of a rare disease-hepatosplenic T-cell lymphoma. ( 15633661 )
2004
106
Hematologic malignancies with extramedullary spread of disease. Case 2. Hepatosplenic T-cell lymphoma. ( 12721269 )
2003
107
Hepatosplenic T cell lymphoma with no expression of cytotoxic molecules. ( 12890821 )
2003
108
Fluorescence in situ hybridization study of chromosome 7 aberrations in hepatosplenic T-cell lymphoma: isochromosome 7q as a common abnormality accumulating in forms with features of cytologic progression. ( 11807981 )
2002
109
Hepatosplenic T-cell lymphoma in a mare. ( 12126157 )
2002
110
Hepatosplenic T-cell lymphoma of alphabeta lineage. ( 11420473 )
2001
111
Hepatosplenic T-cell lymphoma. ( 11472337 )
2001
112
Hepatosplenic T-cell lymphoma of alphabeta lineage in a 16-year-old boy presenting with hemolytic anemia and thrombocytopenia. ( 10716161 )
2000
113
Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. ( 10865963 )
2000
114
Hepatosplenic alphabeta T-cell lymphoma: an unusual case with clinical, histologic, and cytogenetic features of gammadelta hepatosplenic T-cell lymphoma. ( 10895827 )
2000
115
CD26 expression and dipeptidyl peptidase IV activity in an aggressive hepatosplenic T-cell lymphoma. ( 9511938 )
1998
116
Cytotoxic T-lymphocyte differentiation and cytogenetic alterations in gammadelta hepatosplenic T-cell lymphoma and posttransplant lymphoproliferative disorders. ( 9129060 )
1997
117
Hepatosplenic T-cell lymphoma: prolymphocytic transformation 18 months after splenectomy. ( 9277054 )
1997
118
Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic gamma delta T-cell origin. ( 8943863 )
1996
119
Hepatosplenic T-cell lymphoma: sinusoidal localization of malignant T-cells--a case report. ( 8948673 )
1996
120
Hepatosplenic T-cell lymphoma: an unusual case of a gamma delta T-cell lymphoma with a blast-like terminal transformation. ( 8314255 )
1994
121
Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor gamma delta. ( 2140703 )
1990

Variations for Hepatosplenic T-Cell Lymphoma

Expression for Hepatosplenic T-Cell Lymphoma

LifeMap Discovery
Genes differentially expressed in tissues of Hepatosplenic T-Cell Lymphoma patients vs. healthy controls: 35 (showing 400, show less)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 TMEM178A transmembrane protein 178A Spleen + 9.71 0.000
2 LPAR3 lysophosphatidic acid receptor 3 Spleen + 8.91 0.000
3 SOX2 SRY (sex determining region Y)-box 2 Spleen + 8.60 0.000
4 MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 Spleen + 7.68 0.001
5 CLEC3B C-type lectin domain family 3, member B Spleen - 7.16 0.001
6 KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 Spleen + 7.16 0.000
7 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 Spleen - 7.01 0.023
8 KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 Spleen + 6.95 0.000
9 KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1 Spleen + 6.85 0.001
10 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 Spleen + 6.83 0.000
11 KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 Spleen + 6.66 0.000
12 KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 Spleen + 6.63 0.001
13 MARCO macrophage receptor with collagenous structure Spleen + 6.61 0.009
14 KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 Spleen + 6.34 0.001
15 CXCL13 chemokine (C-X-C motif) ligand 13 Spleen - 6.26 0.004
16 OLFML2A olfactomedin-like 2A Spleen - 6.25 0.015
17 KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 Spleen + 6.21 0.002
18 KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 Spleen + 6.14 0.000
19 KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 Spleen + 6.13 0.001
20 GREB1 growth regulation by estrogen in breast cancer 1 Spleen + 6.09 0.001
21 KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 Spleen + 6.02 0.002
22 LOC100505501 uncharacterized LOC100505501 Spleen + 5.96 0.000
23 MAATS1 MYCBP-associated, testis expressed 1 Spleen - 5.93 0.000
24 TRGV5 T cell receptor gamma variable 5 Spleen + 5.90 0.000
25 CRHBP corticotropin releasing hormone binding protein Spleen - 5.89 0.000
26 KLRC3 killer cell lectin-like receptor subfamily C, member 3 Spleen + 5.87 0.000
27 SMIM24 small integral membrane protein 24 Spleen + 5.85 0.000
28 CCM2L cerebral cavernous malformation 2-like Spleen - 5.83 0.005
29 RUNDC3B RUN domain containing 3B Spleen + 5.82 0.000
30 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 Spleen + 5.80 0.000
31 PCDH7 protocadherin 7 Spleen - 5.78 0.010
32 APLNR apelin receptor Spleen - 5.76 0.000
33 KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A Spleen + 5.73 0.001
34 KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 Spleen + 5.69 0.001
35 GIPC2 GIPC PDZ domain containing family, member 2 Spleen - 5.69 0.000
36 GTSF1 gametocyte specific factor 1 Spleen + 5.62 0.001
37 GPM6A glycoprotein M6A Spleen - 5.62 0.000
38 IGFBP3 insulin-like growth factor binding protein 3 Spleen - 5.61 0.004
39 BMP7 bone morphogenetic protein 7 Spleen + 5.59 0.000
40 PDE2A phosphodiesterase 2A, cGMP-stimulated Spleen - 5.58 0.002
41 KIF14 kinesin family member 14 Spleen + 5.55 0.000
42 HYAL1 hyaluronoglucosaminidase 1 Spleen - 5.51 0.006
43 GPR82 G protein-coupled receptor 82 Spleen + 5.49 0.000
44 DNASE1L3 deoxyribonuclease I-like 3 Spleen - 5.44 0.003
45 USP44 ubiquitin specific peptidase 44 Spleen + 5.44 0.000
46 CD96 CD96 molecule Spleen + 5.42 0.001
47 AKAP5 A kinase (PRKA) anchor protein 5 Spleen + 5.41 0.000
48 RNASE1 ribonuclease, RNase A family, 1 (pancreatic) Spleen - 5.40 0.008
49 PLVAP plasmalemma vesicle associated protein Spleen - 5.38 0.001
50 NEK2 NIMA-related kinase 2 Spleen + 5.35 0.000
51 KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 Spleen - 5.29 0.000
52 HCAR3 hydroxycarboxylic acid receptor 3 Spleen - 5.29 0.006
53 CHODL chondrolectin Spleen - 5.28 0.001
54 GBA3 glucosidase, beta, acid 3 (gene/pseudogene) Spleen - 5.25 0.000
55 NCAM1 neural cell adhesion molecule 1 Spleen + 5.19 0.003
56 PBK PDZ binding kinase Spleen + 5.16 0.000
57 DLGAP5 discs, large (Drosophila) homolog-associated protein 5 Spleen + 5.13 0.001
58 HSPB8 heat shock 22kDa protein 8 Spleen - 5.11 0.002
59 PITPNM3 PITPNM family member 3 Spleen - 5.09 0.010
60 CHMP4C charged multivesicular body protein 4C Spleen - 5.09 0.000
61 PTX3 pentraxin 3, long Spleen - 5.07 0.012
62 KIF20A kinesin family member 20A Spleen + 5.05 0.000
63 FAM110B family with sequence similarity 110, member B Spleen - 5.04 0.005
64 SDPR serum deprivation response Spleen - 5.03 0.012
65 BIRC5 baculoviral IAP repeat containing 5 Spleen + 5.02 0.000
66 LIMCH1 LIM and calponin homology domains 1 Spleen - 4.99 0.006
67 CENPF centromere protein F, 350/400kDa Spleen + 4.98 0.000
68 TOP2A topoisomerase (DNA) II alpha Spleen + 4.98 0.000
69 KIAA0101 KIAA0101 Spleen + 4.98 0.000
70 ZNF521 zinc finger protein 521 Spleen - 4.96 0.004
71 KIF2C kinesin family member 2C Spleen + 4.95 0.000
72 ASPM abnormal spindle microtubule assembly Spleen + 4.94 0.001
73 TSPAN12 tetraspanin 12 Spleen - 4.93 0.006
74 TEK TEK tyrosine kinase, endothelial Spleen - 4.92 0.021
75 SLCO4C1 solute carrier organic anion transporter family, member 4C1 Spleen + 4.91 0.001
76 BUB1 BUB1 mitotic checkpoint serine/threonine kinase Spleen + 4.89 0.001
77 SEPP1 selenoprotein P, plasma, 1 Spleen - 4.89 0.000
78 CD79A CD79a molecule, immunoglobulin-associated alpha Spleen - 4.89 0.039
79 ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Spleen - 4.85 0.000
80 ADAMDEC1 ADAM-like, decysin 1 Spleen - 4.85 0.008
81 UHRF1 ubiquitin-like with PHD and ring finger domains 1 Spleen + 4.84 0.000
82 FLRT3 fibronectin leucine rich transmembrane protein 3 Spleen + 4.82 0.012
83 PCDH17 protocadherin 17 Spleen - 4.82 0.041
84 BLNK B-cell linker Spleen - 4.81 0.036
85 SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 Spleen - 4.80 0.004
86 CDKN3 cyclin-dependent kinase inhibitor 3 Spleen + 4.80 0.001
87 DSP desmoplakin Spleen - 4.79 0.000
88 STAB2 stabilin 2 Spleen - 4.74 0.022
89 TPX2 TPX2, microtubule-associated Spleen + 4.73 0.000
90 KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 Spleen + 4.73 0.000
91 CFI complement factor I Spleen - 4.72 0.025
92 CENPA centromere protein A Spleen + 4.70 0.001
93 PDGFD platelet derived growth factor D Spleen + 4.69 0.000
94 TK1 thymidine kinase 1, soluble Spleen + 4.67 0.000
95 CENPE centromere protein E, 312kDa Spleen + 4.66 0.000
96 FCRLB Fc receptor-like B Spleen + 4.66 0.001
97 HOMER3 homer scaffolding protein 3 Spleen - 4.65 0.022
98 KIF18B kinesin family member 18B Spleen + 4.65 0.001
99 NKX2-3 NK2 homeobox 3 Spleen - 4.64 0.026
100 GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 Spleen - 4.64 0.000
101 DEPDC1 DEP domain containing 1 Spleen + 4.63 0.000
102 TARP TCR gamma alternate reading frame protein Spleen + 4.63 0.000
103 PTPRB protein tyrosine phosphatase, receptor type, B Spleen - 4.61 0.013
104 KLF4 Kruppel-like factor 4 (gut) Spleen - 4.60 0.011
105 TMSB15A thymosin beta 15a Spleen + 4.60 0.002
106 AXL AXL receptor tyrosine kinase Spleen - 4.60 0.001
107 SIRPG signal-regulatory protein gamma Spleen + 4.59 0.000
108 MIB2 mindbomb E3 ubiquitin protein ligase 2 Spleen + 4.59 0.000
109 CNTN1 contactin 1 Spleen - 4.59 0.000
110 E2F7 E2F transcription factor 7 Spleen + 4.59 0.000
111 CYYR1 cysteine/tyrosine-rich 1 Spleen - 4.58 0.002
112 KAZN kazrin, periplakin interacting protein Spleen - 4.57 0.003
113 EPHA7 EPH receptor A7 Spleen - 4.56 0.000
114 GINS2 GINS complex subunit 2 (Psf2 homolog) Spleen + 4.56 0.000
115 DEPDC1B DEP domain containing 1B Spleen + 4.55 0.000
116 NUF2 NUF2, NDC80 kinetochore complex component Spleen + 4.55 0.000
117 ADIRF adipogenesis regulatory factor Spleen - 4.55 0.008
118 CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) Spleen - 4.55 0.015
119 FAM83D family with sequence similarity 83, member D Spleen + 4.54 0.000
120 TYMS thymidylate synthetase Spleen + 4.53 0.000
121 FOXM1 forkhead box M1 Spleen + 4.53 0.000
122 C1orf115 chromosome 1 open reading frame 115 Spleen - 4.52 0.007
123 TCL1A T-cell leukemia/lymphoma 1A Spleen - 4.52 0.024
124 UBE2C ubiquitin-conjugating enzyme E2C Spleen + 4.52 0.000
125 THBD thrombomodulin Spleen - 4.51 0.022
126 S100B S100 calcium binding protein B Spleen + 4.50 0.022
127 MKI67 marker of proliferation Ki-67 Spleen + 4.50 0.000
128 ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 Spleen - 4.49 0.000
129 GPR183 G protein-coupled receptor 183 Spleen - 4.48 0.012
130 KIF15 kinesin family member 15 Spleen + 4.48 0.001
131 CD163L1 CD163 molecule-like 1 Spleen - 4.47 0.001
132 ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 Spleen + 4.47 0.000
133 NOS3 nitric oxide synthase 3 (endothelial cell) Spleen - 4.47 0.021
134 OIP5 Opa interacting protein 5 Spleen + 4.46 0.000
135 SLC16A9 solute carrier family 16, member 9 Spleen - 4.46 0.010
136 CEP55 centrosomal protein 55kDa Spleen + 4.46 0.000
137 ROBO4 roundabout guidance receptor 4 Spleen - 4.46 0.007
138 CXCL12 chemokine (C-X-C motif) ligand 12 Spleen - 4.44 0.011
139 LGR4 leucine-rich repeat containing G protein-coupled receptor 4 Spleen - 4.44 0.000
140 THRB thyroid hormone receptor, beta Spleen - 4.43 0.000
141 MYCT1 myc target 1 Spleen - 4.43 0.010
142 E2F8 E2F transcription factor 8 Spleen + 4.42 0.000
143 TMEM200A transmembrane protein 200A Spleen + 4.42 0.002
144 AIF1L allograft inflammatory factor 1-like Spleen - 4.42 0.029
145 PSD3 pleckstrin and Sec7 domain containing 3 Spleen - 4.42 0.005
146 NDRG2 NDRG family member 2 Spleen - 4.41 0.006
147 CCNB2 cyclin B2 Spleen + 4.40 0.001
148 EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) Spleen - 4.39 0.019
149 NDRG4 NDRG family member 4 Spleen - 4.39 0.000
150 MCM10 minichromosome maintenance 10 replication initiation factor Spleen + 4.39 0.000
151 TOX thymocyte selection-associated high mobility group box Spleen + 4.36 0.001
152 APOE apolipoprotein E Spleen - 4.36 0.016
153 HJURP Holliday junction recognition protein Spleen + 4.36 0.000
154 CHSY3 chondroitin sulfate synthase 3 Spleen + 4.36 0.000
155 CCL24 chemokine (C-C motif) ligand 24 Spleen - 4.36 0.001
156 MET MET proto-oncogene, receptor tyrosine kinase Spleen - 4.35 0.001
157 CDCA7 cell division cycle associated 7 Spleen + 4.34 0.001
158 VWF von Willebrand factor Spleen - 4.34 0.021
159 ARHGAP28 Rho GTPase activating protein 28 Spleen - 4.34 0.014
160 PRC1 protein regulator of cytokinesis 1 Spleen + 4.34 0.000
161 IGHD immunoglobulin heavy constant delta Spleen - 4.34 0.012
162 MGP matrix Gla protein Spleen - 4.34 0.010
163 CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 Spleen - 4.34 0.000
164 RTN1 reticulon 1 Spleen - 4.33 0.035
165 SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) Spleen + 4.33 0.006
166 FAM179A family with sequence similarity 179, member A Spleen + 4.32 0.001
167 MYRIP myosin VIIA and Rab interacting protein Spleen - 4.32 0.004
168 EFHD1 EF-hand domain family, member D1 Spleen - 4.32 0.023
169 TSPAN7 tetraspanin 7 Spleen - 4.31 0.017
170 CPB1 carboxypeptidase B1 (tissue) Spleen - 4.31 0.000
171 FCRLA Fc receptor-like A Spleen - 4.29 0.027
172 FPR3 formyl peptide receptor 3 Spleen - 4.29 0.019
173 KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 Spleen + 4.29 0.009
174 CCNA2 cyclin A2 Spleen + 4.28 0.000
175 SHANK3 SH3 and multiple ankyrin repeat domains 3 Spleen - 4.27 0.011
176 CD22 CD22 molecule Spleen - 4.27 0.023
177 FXYD6 FXYD domain containing ion transport regulator 6 Spleen - 4.27 0.026
178 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit Spleen + 4.27 0.000
179 ANLN anillin actin binding protein Spleen + 4.26 0.000
180 NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 Spleen + 4.25 0.010
181 NUSAP1 nucleolar and spindle associated protein 1 Spleen + 4.25 0.000
182 AURKB aurora kinase B Spleen + 4.24 0.000
183 CAV1 caveolin 1, caveolae protein, 22kDa Spleen - 4.22 0.017
184 BUB1B BUB1 mitotic checkpoint serine/threonine kinase B Spleen + 4.21 0.000
185 FASLG Fas ligand (TNF superfamily, member 6) Spleen + 4.21 0.000
186 PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 Spleen - 4.20 0.005
187 CDC20 cell division cycle 20 Spleen + 4.20 0.003
188 INSR insulin receptor Spleen - 4.20 0.020
189 C8orf4 chromosome 8 open reading frame 4 Spleen - 4.20 0.015
190 CNTN3 contactin 3 (plasmacytoma associated) Spleen - 4.20 0.000
191 CD247 CD247 molecule Spleen + 4.19 0.000
192 EPPK1 epiplakin 1 Spleen - 4.19 0.001
193 PRSS21 protease, serine, 21 (testisin) Spleen + 4.19 0.000
194 NOG noggin Spleen + 4.18 0.033
195 CDCA2 cell division cycle associated 2 Spleen + 4.18 0.000
196 GTSE1 G-2 and S-phase expressed 1 Spleen + 4.18 0.001
197 SH2D2A SH2 domain containing 2A Spleen + 4.17 0.000
198 FLJ35700 uncharacterized protein FLJ35700 Spleen - 4.17 0.008
199 RRM2 ribonucleotide reductase M2 Spleen + 4.16 0.001
200 C2orf40 chromosome 2 open reading frame 40 Spleen - 4.15 0.032
201 MELK maternal embryonic leucine zipper kinase Spleen + 4.15 0.000
202 CASC5 cancer susceptibility candidate 5 Spleen + 4.15 0.000
203 PAX5 paired box 5 Spleen - 4.14 0.044
204 LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 Spleen - 4.14 0.017
205 CCNB1 cyclin B1 Spleen + 4.13 0.001
206 SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 Spleen + 4.13 0.009
207 ADGRF5 adhesion G protein-coupled receptor F5 Spleen - 4.13 0.046
208 KLHL14 kelch-like family member 14 Spleen - 4.12 0.038
209 VPREB3 pre-B lymphocyte 3 Spleen - 4.12 0.018
210 MEST mesoderm specific transcript Spleen - 4.11 0.006
211 ERG v-ets avian erythroblastosis virus E26 oncogene homolog Spleen - 4.11 0.009
212 KLRC4 killer cell lectin-like receptor subfamily C, member 4 Spleen + 4.10 0.028
213 NCAPG non-SMC condensin I complex, subunit G Spleen + 4.10 0.000
214 NR4A2 nuclear receptor subfamily 4, group A, member 2 Spleen + 4.10 0.045
215 CCNE2 cyclin E2 Spleen + 4.10 0.000
216 TM4SF18 transmembrane 4 L six family member 18 Spleen - 4.09 0.035
217 BRIP1 BRCA1 interacting protein C-terminal helicase 1 Spleen + 4.09 0.000
218 IGF1 insulin-like growth factor 1 (somatomedin C) Spleen - 4.08 0.001
219 FCRL2 Fc receptor-like 2 Spleen - 4.08 0.013
220 HMMR hyaluronan-mediated motility receptor (RHAMM) Spleen + 4.07 0.001
221 TMEM150C transmembrane protein 150C Spleen - 4.07 0.007
222 ITGA1 integrin, alpha 1 Spleen - 4.07 0.048
223 NELL2 neural EGFL like 2 Spleen + 4.06 0.006
224 NTN4 netrin 4 Spleen - 4.06 0.016
225 CAV2 caveolin 2 Spleen - 4.06 0.014
226 CKAP2L cytoskeleton associated protein 2-like Spleen + 4.05 0.000
227 CDK1 cyclin-dependent kinase 1 Spleen + 4.05 0.000
228 LY86 lymphocyte antigen 86 Spleen - 4.05 0.007
229 CDT1 chromatin licensing and DNA replication factor 1 Spleen + 4.05 0.000
230 RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 Spleen - 4.05 0.003
231 C3orf70 chromosome 3 open reading frame 70 Spleen - 4.04 0.001
232 SPAG5 sperm associated antigen 5 Spleen + 4.03 0.000
233 APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 Spleen + 4.03 0.001
234 TRIM2 tripartite motif containing 2 Spleen - 4.03 0.010
235 ERAP2 endoplasmic reticulum aminopeptidase 2 Spleen - 4.02 0.000
236 NMU neuromedin U Spleen + 4.02 0.022
237 KLRD1 killer cell lectin-like receptor subfamily D, member 1 Spleen + 4.02 0.000
238 TTK TTK protein kinase Spleen + 4.01 0.000
239 RAMP1 receptor (G protein-coupled) activity modifying protein 1 Spleen + 4.01 0.012
240 FCRL1 Fc receptor-like 1 Spleen - 4.01 0.006
241 ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 Spleen - 4.00 0.007
242 CRTAM cytotoxic and regulatory T cell molecule Spleen + 4.00 0.000
243 LIFR leukemia inhibitory factor receptor alpha Spleen - 4.00 0.049
244 TREM1 triggering receptor expressed on myeloid cells 1 Spleen - 3.99 0.000
245 MOB3B MOB kinase activator 3B Spleen - 3.99 0.027
246 LRP4 low density lipoprotein receptor-related protein 4 Spleen - 3.99 0.000
247 STOX2 storkhead box 2 Spleen - 3.99 0.001
248 CHEK1 checkpoint kinase 1 Spleen + 3.99 0.000
249 ACKR1 atypical chemokine receptor 1 (Duffy blood group) Spleen - 3.98 0.015
250 FABP3 fatty acid binding protein 3, muscle and heart Spleen - 3.98 0.015
251 MMRN2 multimerin 2 Spleen - 3.98 0.005
252 AGTR1 angiotensin II receptor, type 1 Spleen - 3.97 0.013
253 GNLY granulysin Spleen - 3.97 0.038
254 EBF1 early B-cell factor 1 Spleen - 3.96 0.011
255 SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 Spleen - 3.95 0.008
256 MCM4 minichromosome maintenance complex component 4 Spleen + 3.94 0.000
257 TMTC1 transmembrane and tetratricopeptide repeat containing 1 Spleen - 3.94 0.039
258 KIF11 kinesin family member 11 Spleen + 3.94 0.000
259 LGALS2 lectin, galactoside-binding, soluble, 2 Spleen - 3.93 0.004
260 PLK2 polo-like kinase 2 Spleen - 3.92 0.012
261 TRD T cell receptor delta locus Spleen + 3.92 0.024
262 IGSF21 immunoglobin superfamily, member 21 Spleen - 3.92 0.000
263 S1PR5 sphingosine-1-phosphate receptor 5 Spleen + 3.92 0.006
264 PCSK6 proprotein convertase subtilisin/kexin type 6 Spleen - 3.91 0.005
265 SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D Spleen - 3.91 0.007
266 PHGDH phosphoglycerate dehydrogenase Spleen + 3.91 0.008
267 GAPT GRB2-binding adaptor protein, transmembrane Spleen - 3.90 0.026
268 SPIB Spi-B transcription factor (Spi-1/PU.1 related) Spleen - 3.90 0.016
269 CDC6 cell division cycle 6 Spleen + 3.90 0.001
270 UBE2T ubiquitin-conjugating enzyme E2T Spleen + 3.89 0.000
271 RMI2 RecQ mediated genome instability 2 Spleen + 3.88 0.000
272 ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 Spleen - 3.88 0.000
273 BLK BLK proto-oncogene, Src family tyrosine kinase Spleen - 3.87 0.004
274 FGD5 FYVE, RhoGEF and PH domain containing 5 Spleen - 3.87 0.004
275 ELOVL6 ELOVL fatty acid elongase 6 Spleen + 3.86 0.004
276 NCAPH non-SMC condensin I complex, subunit H Spleen + 3.86 0.000
277 HOMER1 homer scaffolding protein 1 Spleen + 3.85 0.002
278 ITGAD integrin, alpha D Spleen + 3.85 0.001
279 ARHGAP29 Rho GTPase activating protein 29 Spleen - 3.84 0.023
280 MPPED2 metallophosphoesterase domain containing 2 Spleen - 3.84 0.004
281 ADGRL4 adhesion G protein-coupled receptor L4 Spleen - 3.83 0.050
282 CCL19 chemokine (C-C motif) ligand 19 Spleen - 3.83 0.037
283 NAV3 neuron navigator 3 Spleen - 3.83 0.001
284 NRP1 neuropilin 1 Spleen - 3.83 0.034
285 HLA-DOB major histocompatibility complex, class II, DO beta Spleen - 3.82 0.034
286 PROX1 prospero homeobox 1 Spleen - 3.82 0.003
287 CDCA8 cell division cycle associated 8 Spleen + 3.82 0.000
288 RORB RAR-related orphan receptor B Spleen + 3.81 0.004
289 CDCA5 cell division cycle associated 5 Spleen + 3.81 0.000
290 CES1 carboxylesterase 1 Spleen - 3.81 0.017
291 ASB9 ankyrin repeat and SOCS box containing 9 Spleen - 3.81 0.000
292 MYH11 myosin, heavy chain 11, smooth muscle Spleen - 3.79 0.027
293 SPC25 SPC25, NDC80 kinetochore complex component Spleen + 3.79 0.000
294 PLPP3 phospholipid phosphatase 3 Spleen - 3.79 0.024
295 JAKMIP2 janus kinase and microtubule interacting protein 2 Spleen + 3.79 0.003
296 ATAD2 ATPase family, AAA domain containing 2 Spleen + 3.79 0.000
297 MRAP2 melanocortin 2 receptor accessory protein 2 Spleen - 3.77 0.002
298 ITM2A integral membrane protein 2A Spleen + 3.77 0.007
299 MND1 meiotic nuclear divisions 1 Spleen + 3.76 0.002
300 AMIGO2 adhesion molecule with Ig-like domain 2 Spleen - 3.76 0.019
301 BCHE butyrylcholinesterase Spleen - 3.76 0.003
302 SHE Src homology 2 domain containing E Spleen - 3.76 0.012
303 CD37 CD37 molecule Spleen - 3.76 0.042
304 JUN jun proto-oncogene Spleen - 3.76 0.013
305 GNG7 guanine nucleotide binding protein (G protein), gamma 7 Spleen - 3.75 0.000
306 ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein Spleen - 3.74 0.006
307 EXO1 exonuclease 1 Spleen + 3.74 0.000
308 GNG12 guanine nucleotide binding protein (G protein), gamma 12 Spleen - 3.73 0.042
309 FAM129C family with sequence similarity 129, member C Spleen - 3.73 0.012
310 PTGDR prostaglandin D2 receptor (DP) Spleen + 3.72 0.000
311 AQP3 aquaporin 3 (Gill blood group) Spleen - 3.72 0.005
312 GINS1 GINS complex subunit 1 (Psf1 homolog) Spleen + 3.72 0.000
313 IGHA1 immunoglobulin heavy constant alpha 1 Spleen - 3.72 0.005
314 POLE2 polymerase (DNA directed), epsilon 2, accessory subunit Spleen + 3.72 0.000
315 CDH2 cadherin 2, type 1, N-cadherin (neuronal) Spleen - 3.71 0.016
316 NPR3 natriuretic peptide receptor 3 Spleen - 3.71 0.000
317 GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 Spleen - 3.71 0.000
318 TRIP13 thyroid hormone receptor interactor 13 Spleen + 3.70 0.001
319 DUSP1 dual specificity phosphatase 1 Spleen - 3.70 0.002
320 GLI3 GLI family zinc finger 3 Spleen + 3.68 0.004
321 AQP9 aquaporin 9 Spleen - 3.68 0.049
322 PLEKHA5 pleckstrin homology domain containing, family A member 5 Spleen + 3.67 0.001
323 NRN1 neuritin 1 Spleen - 3.67 0.004
324 PNOC prepronociceptin Spleen - 3.67 0.008
325 CAMTA1 calmodulin binding transcription activator 1 Spleen - 3.67 0.008
326 SNCAIP synuclein, alpha interacting protein Spleen - 3.67 0.026
327 OLFM1 olfactomedin 1 Spleen - 3.66 0.000
328 AFF3 AF4/FMR2 family, member 3 Spleen - 3.66 0.008
329 TMEM100 transmembrane protein 100 Spleen - 3.66 0.038
330 SPC24 SPC24, NDC80 kinetochore complex component Spleen + 3.66 0.004
331 HELLS helicase, lymphoid-specific Spleen + 3.65 0.000
332 BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) Spleen - 3.65 0.036
333 ITGA6 integrin, alpha 6 Spleen - 3.64 0.011
334 ZWINT ZW10 interacting kinetochore protein Spleen + 3.64 0.000
335 IL13RA1 interleukin 13 receptor, alpha 1 Spleen - 3.64 0.028
336 NDN necdin, melanoma antigen (MAGE) family member Spleen - 3.63 0.032
337 BTNL9 butyrophilin-like 9 Spleen - 3.63 0.020
338 KIF18A kinesin family member 18A Spleen + 3.63 0.000
339 AS3MT arsenite methyltransferase Spleen - 3.63 0.033
340 EGFL7 EGF-like-domain, multiple 7 Spleen - 3.62 0.002
341 EOMES eomesodermin Spleen + 3.62 0.001
342 FAM107A family with sequence similarity 107, member A Spleen - 3.62 0.020
343 TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 Spleen + 3.61 0.013
344 FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) Spleen - 3.61 0.013
345 BHLHE41 basic helix-loop-helix family, member e41 Spleen - 3.61 0.031
346 CDCA3 cell division cycle associated 3 Spleen + 3.59 0.001
347 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) Spleen - 3.59 0.009
348 PRDM16 PR domain containing 16 Spleen + 3.58 0.000
349 C18orf54 chromosome 18 open reading frame 54 Spleen + 3.57 0.002
350 ANGPTL2 angiopoietin-like 2 Spleen - 3.57 0.034
351 DOCK5 dedicator of cytokinesis 5 Spleen - 3.57 0.001
352 LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 Spleen - 3.56 0.002
353 ARHGAP24 Rho GTPase activating protein 24 Spleen - 3.55 0.000
354 AURKA aurora kinase A Spleen + 3.55 0.001
355 AREG amphiregulin Spleen + 3.55 0.032
356 RAD51 RAD51 recombinase Spleen + 3.55 0.000
357 IL7R interleukin 7 receptor Spleen - 3.54 0.026
358 FAM9C family with sequence similarity 9, member C Spleen - 3.54 0.008
359 FAM150B family with sequence similarity 150, member B Spleen - 3.53 0.008
360 C5AR1 complement component 5a receptor 1 Spleen - 3.52 0.048
361 CD8B CD8b molecule Spleen + 3.52 0.039
362 NRXN3 neurexin 3 Spleen - 3.52 0.005
363 TCF19 transcription factor 19 Spleen + 3.52 0.000
364 CDRT4 CMT1A duplicated region transcript 4 Spleen + 3.52 0.019
365 CD3G CD3g molecule, gamma (CD3-TCR complex) Spleen + 3.52 0.002
366 PROK2 prokineticin 2 Spleen - 3.51 0.006
367 CSF3R colony stimulating factor 3 receptor (granulocyte) Spleen - 3.51 0.001
368 TLR10 toll-like receptor 10 Spleen - 3.51 0.017
369 GMPR guanosine monophosphate reductase Spleen + 3.50 0.013
370 MMP16 matrix metallopeptidase 16 (membrane-inserted) Spleen + 3.50 0.001
371 DIAPH3 diaphanous-related formin 3 Spleen + 3.50 0.000
372 ASF1B anti-silencing function 1B histone chaperone Spleen + 3.49 0.001
373 FANCI Fanconi anemia, complementation group I Spleen + 3.47 0.001
374 GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) Spleen + 3.46 0.002
375 MCM2 minichromosome maintenance complex component 2 Spleen + 3.46 0.000
376 KIFC1 kinesin family member C1 Spleen + 3.45 0.000
377 SH3RF3 SH3 domain containing ring finger 3 Spleen + 3.45 0.004
378 RACGAP1 Rac GTPase activating protein 1 Spleen + 3.45 0.000
379 PPP1R9A protein phosphatase 1, regulatory subunit 9A Spleen + 3.43 0.003
380 CENPN centromere protein N Spleen + 3.43 0.001
381 DNA2 DNA replication helicase/nuclease 2 Spleen + 3.42 0.000
382 CENPW centromere protein W Spleen + 3.41 0.001
383 CENPU centromere protein U Spleen + 3.39 0.000
384 WDHD1 WD repeat and HMG-box DNA binding protein 1 Spleen + 3.39 0.001
385 AKAP12 A kinase (PRKA) anchor protein 12 Spleen + 3.37 0.003
386 DSCC1 DNA replication and sister chromatid cohesion 1 Spleen + 3.36 0.001
387 ESPL1 extra spindle pole bodies like 1, separase Spleen + 3.36 0.000
388 MCM7 minichromosome maintenance complex component 7 Spleen + 3.36 0.001
389 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) Spleen + 3.35 0.000
390 MYH10 myosin, heavy chain 10, non-muscle Spleen + 3.34 0.009
391 LARP6 La ribonucleoprotein domain family, member 6 Spleen + 3.34 0.025
392 CENPK centromere protein K Spleen + 3.31 0.000
393 POLQ polymerase (DNA directed), theta Spleen + 3.29 0.000
394 TRDV3 T cell receptor delta variable 3 Spleen + 3.29 0.029
395 SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 Spleen + 3.28 0.002
396 PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) Spleen + 3.28 0.001
397 THEMIS thymocyte selection associated Spleen + 3.28 0.000
398 PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Spleen + 3.27 0.001
399 CMC1 C-x(9)-C motif containing 1 Spleen + 3.26 0.000
400 DPY19L2P2 DPY19L2 pseudogene 2 Spleen + 3.25 0.002
Search GEO for disease gene expression data for Hepatosplenic T-Cell Lymphoma.

Pathways for Hepatosplenic T-Cell Lymphoma

GO Terms for Hepatosplenic T-Cell Lymphoma

Biological processes related to Hepatosplenic T-Cell Lymphoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 8.8 CD7 DPP4 PIK3CD

Molecular functions related to Hepatosplenic T-Cell Lymphoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 alpha-tubulin binding GO:0043014 8.62 INO80 SETD2

Sources for Hepatosplenic T-Cell Lymphoma

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
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