MCID: HR2002
MIFTS: 19

Her2-Receptor Negative Breast Cancer

Categories: Cancer diseases

Aliases & Classifications for Her2-Receptor Negative Breast Cancer

MalaCards integrated aliases for Her2-Receptor Negative Breast Cancer:

Name: Her2-Receptor Negative Breast Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060080

Summaries for Her2-Receptor Negative Breast Cancer

Disease Ontology : 12 A breast cancer that is characterized by the absence of Her2 receptors.

MalaCards based summary : Her2-Receptor Negative Breast Cancer is related to fetal akinesia deformation sequence 1. An important gene associated with Her2-Receptor Negative Breast Cancer is ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The drugs Doxorubicin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include breast and liver, and related phenotype is hematopoietic system.

Related Diseases for Her2-Receptor Negative Breast Cancer

Diseases in the Her2-Receptor Positive Breast Cancer family:

Her2-Receptor Negative Breast Cancer

Diseases related to Her2-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fetal akinesia deformation sequence 1 9.6 ACSL4 ACSL3

Symptoms & Phenotypes for Her2-Receptor Negative Breast Cancer

MGI Mouse Phenotypes related to Her2-Receptor Negative Breast Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.02 ACSL3 ACSL4 ACSL5 ACSL6 PTHLH

Drugs & Therapeutics for Her2-Receptor Negative Breast Cancer

Drugs for Her2-Receptor Negative Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Lenograstim Approved, Investigational Phase 2 135968-09-1
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 27284 23925
6
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
7
Creatine Approved, Investigational, Nutraceutical Phase 2 57-00-1 586
8 Immunologic Factors Phase 2
9
Liposomal doxorubicin Phase 2 31703
10 Albumin-Bound Paclitaxel Phase 2
11 Mitogens Phase 2
12 Chelating Agents Phase 2
13 Immunosuppressive Agents Phase 2
14 Alkylating Agents Phase 2
15 Tubulin Modulators Phase 2
16 Anti-Bacterial Agents Phase 2
17 Antibiotics, Antitubercular Phase 2
18 Antirheumatic Agents Phase 2
19 Liver Extracts Phase 2
20 Antimitotic Agents Phase 2
21 Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Neoadjuvant Carboplatin/Paclitaxel Followed by Dose-Dense Doxorubicin/Cyclophosphamide in Patients With Hormone Receptor Negative, HER2 Receptor Negative Breast Cancer Active, not recruiting NCT03301350 Phase 2 Carboplatin;Paclitaxel;Doxorubicin;Cyclophosphamide;Pegfilgrastim;Filgrastim

Search NIH Clinical Center for Her2-Receptor Negative Breast Cancer

Genetic Tests for Her2-Receptor Negative Breast Cancer

Anatomical Context for Her2-Receptor Negative Breast Cancer

MalaCards organs/tissues related to Her2-Receptor Negative Breast Cancer:

40
Breast, Liver

Publications for Her2-Receptor Negative Breast Cancer

Variations for Her2-Receptor Negative Breast Cancer

Expression for Her2-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Her2-Receptor Negative Breast Cancer.

Pathways for Her2-Receptor Negative Breast Cancer

Pathways related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 ACSL6 ACSL5 ACSL4 ACSL3
2
Show member pathways
12.53 ACSL6 ACSL5 ACSL4 ACSL3
3
Show member pathways
12.19 ACSL6 ACSL5 ACSL4 ACSL3
4 11.62 ACSL6 ACSL5 ACSL4 ACSL3
5 11.56 ACSL6 ACSL5 ACSL4 ACSL3
6 11.46 ACSL6 ACSL5 ACSL4 ACSL3
7
Show member pathways
11.28 ACSL6 ACSL5 ACSL4 ACSL3
8
Show member pathways
11.22 ACSL5 ACSL3
9 11.07 ACSL6 ACSL5 ACSL4 ACSL3
10 10.6 ACSL6 ACSL5 ACSL4 ACSL3
11 10.18 ACSL6 ACSL5 ACSL4 ACSL3

GO Terms for Her2-Receptor Negative Breast Cancer

Cellular components related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.73 ACSL6 ACSL5 ACSL4 ACSL3
2 endoplasmic reticulum GO:0005783 9.67 ACSL6 ACSL5 ACSL4 ACSL3
3 endoplasmic reticulum membrane GO:0005789 9.62 ACSL6 ACSL5 ACSL4 ACSL3
4 peroxisome GO:0005777 9.43 ACSL6 ACSL4 ACSL3
5 lipid droplet GO:0005811 9.4 ACSL4 ACSL3
6 organelle membrane GO:0031090 9.33 ACSL6 ACSL4 ACSL3
7 peroxisomal membrane GO:0005778 9.13 ACSL6 ACSL4 ACSL3
8 mitochondrial outer membrane GO:0005741 8.92 ACSL6 ACSL5 ACSL4 ACSL3

Biological processes related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.62 ACSL6 ACSL5 ACSL4 ACSL3
2 fatty acid metabolic process GO:0006631 9.46 ACSL6 ACSL5 ACSL4 ACSL3
3 neuron differentiation GO:0030182 9.43 ACSL4 ACSL3
4 response to nutrient GO:0007584 9.4 ACSL4 ACSL3
5 lipid biosynthetic process GO:0008610 9.37 ACSL6 ACSL5
6 long-chain fatty-acyl-CoA metabolic process GO:0035336 9.26 ACSL4 ACSL3
7 long-chain fatty acid metabolic process GO:0001676 9.26 ACSL6 ACSL5 ACSL4 ACSL3
8 long-chain fatty-acyl-CoA biosynthetic process GO:0035338 8.92 ACSL6 ACSL5 ACSL4 ACSL3

Molecular functions related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.73 ACSL6 ACSL5 ACSL4 ACSL3
2 ATP binding GO:0005524 9.71 ACSL6 ACSL5 ACSL4 ACSL3
3 catalytic activity GO:0003824 9.67 ACSL6 ACSL5 ACSL4 ACSL3
4 ligase activity GO:0016874 9.62 ACSL6 ACSL5 ACSL4 ACSL3
5 acyl-CoA ligase activity GO:0003996 9.56 ACSL6 ACSL5 ACSL4 ACSL3
6 long-chain fatty acid-CoA ligase activity GO:0004467 9.46 ACSL6 ACSL5 ACSL4 ACSL3
7 arachidonate-CoA ligase activity GO:0047676 9.26 ACSL6 ACSL5 ACSL4 ACSL3
8 decanoate-CoA ligase activity GO:0102391 8.92 ACSL6 ACSL5 ACSL4 ACSL3

Sources for Her2-Receptor Negative Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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