MCID: HR2002
MIFTS: 20

Her2-Receptor Negative Breast Cancer

Categories: Cancer diseases

Aliases & Classifications for Her2-Receptor Negative Breast Cancer

MalaCards integrated aliases for Her2-Receptor Negative Breast Cancer:

Name: Her2-Receptor Negative Breast Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060080

Summaries for Her2-Receptor Negative Breast Cancer

Disease Ontology : 12 A breast cancer that is characterized by the absence of Her2 receptors.

MalaCards based summary : Her2-Receptor Negative Breast Cancer is related to breast adenocarcinoma and wilms tumor 1. An important gene associated with Her2-Receptor Negative Breast Cancer is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drugs Paclitaxel and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include breast and liver, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Her2-Receptor Negative Breast Cancer

Diseases in the Her2-Receptor Positive Breast Cancer family:

Her2-Receptor Negative Breast Cancer

Diseases related to Her2-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 breast adenocarcinoma 9.7 ERBB2 BCL2L1
2 wilms tumor 1 9.7 ERBB2 BCL2L1
3 squamous cell carcinoma, head and neck 9.6 ERBB2 BCL2L1
4 large intestine cancer 9.6 ERBB2 BCL2L1
5 gastric adenocarcinoma 9.6 ERBB2 BCL2L1
6 lung cancer susceptibility 3 9.5 ERBB2 BCL2L1
7 medulloblastoma 9.5 ERBB2 BCL2L1
8 esophageal cancer 9.4 ERBB2 BCL2L1
9 pancreatic cancer 9.2 ERBB2 BCL2L1

Graphical network of the top 20 diseases related to Her2-Receptor Negative Breast Cancer:



Diseases related to Her2-Receptor Negative Breast Cancer

Symptoms & Phenotypes for Her2-Receptor Negative Breast Cancer

GenomeRNAi Phenotypes related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 BCL2L1 ERBB2
2 Decreased viability with paclitaxel GR00179-A-2 8.92 BCL2L1
3 Decreased viability with paclitaxel GR00179-A-3 8.92 BCL2L1

Drugs & Therapeutics for Her2-Receptor Negative Breast Cancer

Drugs for Her2-Receptor Negative Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 23925 27284
4
Lenograstim Approved, Investigational Phase 2 135968-09-1
5
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
6
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
7
Creatine Approved, Investigational, Nutraceutical Phase 2 57-00-1 586
8 Alkylating Agents Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2
10 Hormones Phase 2
11
Liposomal doxorubicin Phase 2 31703
12 Mitogens Phase 2
13 Adjuvants, Immunologic Phase 2
14 Tubulin Modulators Phase 2
15 Albumin-Bound Paclitaxel Phase 2
16 Anti-Bacterial Agents Phase 2
17 Antibiotics, Antitubercular Phase 2
18 Topoisomerase Inhibitors Phase 2
19 Chelating Agents Phase 2
20 Immunosuppressive Agents Phase 2
21 Liver Extracts Phase 2
22 Antimitotic Agents Phase 2
23 Antirheumatic Agents Phase 2
24 Immunologic Factors Phase 2
25 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Neoadjuvant Carboplatin/Paclitaxel Followed by Dose-Dense Doxorubicin/Cyclophosphamide in Patients With Hormone Receptor Negative, HER2 Receptor Negative Breast Cancer Recruiting NCT03301350 Phase 2 Carboplatin;Paclitaxel;Doxorubicin;Cyclophosphamide;Pegfilgrastim;Filgrastim

Search NIH Clinical Center for Her2-Receptor Negative Breast Cancer

Genetic Tests for Her2-Receptor Negative Breast Cancer

Anatomical Context for Her2-Receptor Negative Breast Cancer

MalaCards organs/tissues related to Her2-Receptor Negative Breast Cancer:

41
Breast, Liver

Publications for Her2-Receptor Negative Breast Cancer

Variations for Her2-Receptor Negative Breast Cancer

Expression for Her2-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Her2-Receptor Negative Breast Cancer.

Pathways for Her2-Receptor Negative Breast Cancer

Pathways related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 ERBB2 BCL2L1
2
Show member pathways
12.24 ERBB2 BCL2L1
3 12.2 ERBB2 BCL2L1
4
Show member pathways
12.1 ERBB2 BCL2L1
5
Show member pathways
12.05 ERBB2 BCL2L1
6
Show member pathways
12.03 ERBB2 BCL2L1
7
Show member pathways
11.9 ERBB2 BCL2L1
8
Show member pathways
11.77 ERBB2 BCL2L1
9
Show member pathways
11.58 ERBB2 BCL2L1
10
Show member pathways
11.44 ERBB2 BCL2L1
11 11.11 ERBB2 BCL2L1
12 10.49 ERBB2 BCL2L1

GO Terms for Her2-Receptor Negative Breast Cancer

Cellular components related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 8.62 ERBB2 BCL2L1

Biological processes related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 8.65 BCL2L1
2 cell proliferation GO:0008283 8.32 BCL2L1

Molecular functions related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 8.62 ERBB2 BCL2L1

Sources for Her2-Receptor Negative Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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