MCID: HR2002
MIFTS: 21

Her2-Receptor Negative Breast Cancer

Categories: Cancer diseases

Aliases & Classifications for Her2-Receptor Negative Breast Cancer

MalaCards integrated aliases for Her2-Receptor Negative Breast Cancer:

Name: Her2-Receptor Negative Breast Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060080

Summaries for Her2-Receptor Negative Breast Cancer

MalaCards based summary : Her2-Receptor Negative Breast Cancer is related to breast adenocarcinoma and wilms tumor 1. An important gene associated with Her2-Receptor Negative Breast Cancer is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Her2-Receptor Negative Breast Cancer

Diseases in the Her2-Receptor Positive Breast Cancer family:

Her2-Receptor Negative Breast Cancer

Diseases related to Her2-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 breast adenocarcinoma 9.6 BCL2L1 ERBB2
2 wilms tumor 1 9.6 BCL2L1 ERBB2
3 squamous cell carcinoma, head and neck 9.5 BCL2L1 ERBB2
4 lung cancer susceptibility 3 9.5 BCL2L1 ERBB2
5 gastric adenocarcinoma 9.4 BCL2L1 ERBB2
6 medulloblastoma 9.3 BCL2L1 ERBB2
7 esophageal cancer 9.2 BCL2L1 ERBB2
8 pancreatic cancer 9.0 BCL2L1 ERBB2

Graphical network of the top 20 diseases related to Her2-Receptor Negative Breast Cancer:



Diseases related to Her2-Receptor Negative Breast Cancer

Symptoms & Phenotypes for Her2-Receptor Negative Breast Cancer

GenomeRNAi Phenotypes related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 BCL2L1 ERBB2
2 Decreased viability with paclitaxel GR00179-A-2 8.92 BCL2L1
3 Decreased viability with paclitaxel GR00179-A-3 8.92 BCL2L1

Drugs & Therapeutics for Her2-Receptor Negative Breast Cancer

Drugs for Her2-Receptor Negative Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
4
Iron Approved Phase 2 7439-89-6 23925
5
Lenograstim Approved, Investigational Phase 2 135968-09-1
6
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
7
Doxil Approved June 1999 Phase 2 31703
8 Albumin-Bound Paclitaxel Phase 2
9 Alkylating Agents Phase 2
10 Anti-Bacterial Agents Phase 2
11 Antibiotics, Antitubercular Phase 2
12 Antimitotic Agents Phase 2
13 Antineoplastic Agents, Alkylating Phase 2
14 Antineoplastic Agents, Phytogenic Phase 2
15 Antirheumatic Agents Phase 2
16 Chelating Agents Phase 2
17 Hormones Phase 2
18 Immunosuppressive Agents Phase 2
19 Liver Extracts Phase 2
20 Topoisomerase Inhibitors Phase 2
21
Everolimus Approved 159351-69-6 6442177
22
Exemestane Approved, Investigational 107868-30-4 60198
23
Sirolimus Approved, Investigational 53123-88-9 5284616 6436030 46835353
24 Hormone Antagonists
25 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Carbo/Paclitaxel Followed by Doxorubicin/Cyclophosphamide in Breast Cancer Recruiting NCT03301350 Phase 2 Carboplatin;Paclitaxel;Doxorubicin;Cyclophosphamide;Pegfilgrastim;Filgrastim
2 Investigating Patient Satisfaction With Oral Anti-cancer Treatment in Patients With Hormone-receptor Positive, HER2-receptor Negative, Advanced Breast Cancer Recruiting NCT02875951

Search NIH Clinical Center for Her2-Receptor Negative Breast Cancer

Genetic Tests for Her2-Receptor Negative Breast Cancer

Anatomical Context for Her2-Receptor Negative Breast Cancer

MalaCards organs/tissues related to Her2-Receptor Negative Breast Cancer:

41
Liver

Publications for Her2-Receptor Negative Breast Cancer

Variations for Her2-Receptor Negative Breast Cancer

Expression for Her2-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Her2-Receptor Negative Breast Cancer.

Pathways for Her2-Receptor Negative Breast Cancer

Pathways related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 BCL2L1 ERBB2
2
Show member pathways
12.22 BCL2L1 ERBB2
3 12.18 BCL2L1 ERBB2
4
Show member pathways
12.1 BCL2L1 ERBB2
5
Show member pathways
12.07 BCL2L1 ERBB2
6
Show member pathways
12 BCL2L1 ERBB2
7
Show member pathways
11.85 BCL2L1 ERBB2
8
Show member pathways
11.71 BCL2L1 ERBB2
9
Show member pathways
11.58 BCL2L1 ERBB2
10 11.11 BCL2L1 ERBB2
11 10.49 BCL2L1 ERBB2

GO Terms for Her2-Receptor Negative Breast Cancer

Cellular components related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 8.62 BCL2L1 ERBB2

Biological processes related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 8.96 BCL2L1 ERBB2
2 cell proliferation GO:0008283 8.62 BCL2L1 ERBB2

Molecular functions related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 8.62 BCL2L1 ERBB2

Sources for Her2-Receptor Negative Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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