MCID: HR2002
MIFTS: 23

Her2-Receptor Negative Breast Cancer

Categories: Cancer diseases

Aliases & Classifications for Her2-Receptor Negative Breast Cancer

MalaCards integrated aliases for Her2-Receptor Negative Breast Cancer:

Name: Her2-Receptor Negative Breast Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060080

Summaries for Her2-Receptor Negative Breast Cancer

Disease Ontology : 12 A breast cancer that is characterized by the absence of Her2 receptors.

MalaCards based summary : Her2-Receptor Negative Breast Cancer is related to breast adenocarcinoma and wilms tumor 1. An important gene associated with Her2-Receptor Negative Breast Cancer is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drugs Cyclophosphamide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include breast, liver and lung, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Her2-Receptor Negative Breast Cancer

Diseases in the Her2-Receptor Positive Breast Cancer family:

Her2-Receptor Negative Breast Cancer

Diseases related to Her2-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 breast adenocarcinoma 9.8 BCL2L1 ERBB2
2 wilms tumor 1 9.8 BCL2L1 ERBB2
3 squamous cell carcinoma, head and neck 9.8 BCL2L1 ERBB2
4 large intestine cancer 9.8 BCL2L1 ERBB2
5 gastric adenocarcinoma 9.7 BCL2L1 ERBB2
6 lung cancer susceptibility 3 9.7 BCL2L1 ERBB2
7 medulloblastoma 9.7 BCL2L1 ERBB2
8 esophageal cancer 9.6 BCL2L1 ERBB2
9 pancreatic cancer 9.5 BCL2L1 ERBB2

Graphical network of the top 20 diseases related to Her2-Receptor Negative Breast Cancer:



Diseases related to Her2-Receptor Negative Breast Cancer

Symptoms & Phenotypes for Her2-Receptor Negative Breast Cancer

GenomeRNAi Phenotypes related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 BCL2L1 ERBB2
2 Decreased viability with paclitaxel GR00179-A-2 8.92 BCL2L1
3 Decreased viability with paclitaxel GR00179-A-3 8.92 BCL2L1

Drugs & Therapeutics for Her2-Receptor Negative Breast Cancer

Drugs for Her2-Receptor Negative Breast Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
2
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
3
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 27284 23925
4
Lenograstim Approved, Investigational Phase 2 135968-09-1
5
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
6
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
7
Creatine Approved, Investigational, Nutraceutical Phase 2 57-00-1 586
8
Doxil Approved June 1999 Phase 2 31703
9 Hormones Phase 2
10 Antineoplastic Agents, Alkylating Phase 2
11 Antirheumatic Agents Phase 2
12 Immunologic Factors Phase 2
13 Anti-Bacterial Agents Phase 2
14 Alkylating Agents Phase 2
15 Topoisomerase Inhibitors Phase 2
16 Liver Extracts Phase 2
17 Albumin-Bound Paclitaxel Phase 2
18 Mitogens Phase 2
19 Antibiotics, Antitubercular Phase 2
20 Adjuvants, Immunologic Phase 2
21 Immunosuppressive Agents Phase 2
22 Antimitotic Agents Phase 2
23 Antineoplastic Agents, Phytogenic Phase 2
24 Chelating Agents Phase 2
25
Everolimus Approved 159351-69-6 70789204 6442177
26
Exemestane Approved, Investigational 107868-30-4 60198
27
Sirolimus Approved, Investigational 53123-88-9 46835353 5284616 6436030
28 Hormone Antagonists
29 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Carbo/Paclitaxel Followed by Doxorubicin/Cyclophosphamide in Breast Cancer Suspended NCT03301350 Phase 2 Carboplatin;Paclitaxel;Doxorubicin;Cyclophosphamide;Pegfilgrastim;Filgrastim
2 Investigating Patient Satisfaction With Oral Anti-cancer Treatment in Patients With Hormone-receptor Positive, HER2-receptor Negative, Advanced Breast Cancer Unknown status NCT02875951

Search NIH Clinical Center for Her2-Receptor Negative Breast Cancer

Genetic Tests for Her2-Receptor Negative Breast Cancer

Anatomical Context for Her2-Receptor Negative Breast Cancer

MalaCards organs/tissues related to Her2-Receptor Negative Breast Cancer:

42
Breast, Liver, Lung

Publications for Her2-Receptor Negative Breast Cancer

Variations for Her2-Receptor Negative Breast Cancer

Expression for Her2-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Her2-Receptor Negative Breast Cancer.

Pathways for Her2-Receptor Negative Breast Cancer

Pathways related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.35 BCL2L1 ERBB2
2
Show member pathways
12.24 BCL2L1 ERBB2
3 12.2 BCL2L1 ERBB2
4
Show member pathways
12.1 BCL2L1 ERBB2
5
Show member pathways
12.05 BCL2L1 ERBB2
6
Show member pathways
12.03 BCL2L1 ERBB2
7
Show member pathways
11.9 BCL2L1 ERBB2
8
Show member pathways
11.77 BCL2L1 ERBB2
9
Show member pathways
11.58 BCL2L1 ERBB2
10
Show member pathways
11.44 BCL2L1 ERBB2
11 11.11 BCL2L1 ERBB2
12 10.49 BCL2L1 ERBB2

GO Terms for Her2-Receptor Negative Breast Cancer

Cellular components related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 8.62 BCL2L1 ERBB2

Biological processes related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 8.65 BCL2L1
2 cell proliferation GO:0008283 8.62 BCL2L1 ERBB2

Molecular functions related to Her2-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 8.62 BCL2L1 ERBB2

Sources for Her2-Receptor Negative Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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