MCID: HR2001
MIFTS: 14

Her2-Receptor Positive Breast Cancer

Categories: Cancer diseases

Aliases & Classifications for Her2-Receptor Positive Breast Cancer

MalaCards integrated aliases for Her2-Receptor Positive Breast Cancer:

Name: Her2-Receptor Positive Breast Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060079

Summaries for Her2-Receptor Positive Breast Cancer

Disease Ontology : 12 A breast cancer that is characterized by the presence of Her2 receptors.

MalaCards based summary : Her2-Receptor Positive Breast Cancer is related to bladder adenocarcinoma and microinvasive gastric cancer. An important gene associated with Her2-Receptor Positive Breast Cancer is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways is MicroRNAs in cancer. Affiliated tissues include breast.

Related Diseases for Her2-Receptor Positive Breast Cancer

Diseases in the Her2-Receptor Positive Breast Cancer family:

Her2-Receptor Negative Breast Cancer

Diseases related to Her2-Receptor Positive Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 bladder adenocarcinoma 10.1 UCA1 ERBB2
2 microinvasive gastric cancer 10.0 MIR196A1 ERBB2
3 esophagus adenocarcinoma 10.0 MIR196A1 ERBB2
4 ampulla of vater cancer 10.0 MIR196A1 ERBB2
5 bile duct adenocarcinoma 9.9 MIR196A1 ERBB2
6 leukocyte disease 9.8 MIR196A1 ERBB2
7 thyroid carcinoma 9.8 UCA1 GAS5
8 tongue disease 9.8 UCA1 MIR196A1
9 malignant ovarian surface epithelial-stromal neoplasm 9.8 MIR196A1 ERBB2
10 glioma 9.8 UCA1 GAS5 ERBB2
11 pancreatic ductal adenocarcinoma 9.7 UCA1 MIR196A1 ERBB2
12 leukemia, chronic myeloid 9.7 UCA1 MIR196A1 ERBB2
13 ovary epithelial cancer 9.7 MIR196A1 ERBB2
14 squamous cell carcinoma, head and neck 9.7 MIR196A1 GAS5 ERBB2
15 autonomic nervous system neoplasm 9.6 MIR196A1 MIR103A1 ERBB2
16 peripheral nervous system neoplasm 9.6 MIR196A1 MIR103A1 ERBB2
17 thoracic cancer 9.6 MIR196A1 MIR103A1 ERBB2
18 respiratory system disease 9.5 MIR32 MIR196A1 MIR103A1
19 prostate disease 9.5 MIR196A1 MIR103A1 GAS5
20 cervical cancer 9.5 UCA1 MIR196A1 GAS5 ERBB2
21 nervous system disease 9.5 MIR32 MIR196A1 MIR103A1
22 esophageal cancer 9.4 UCA1 MIR196A1 GAS5 ERBB2
23 bladder cancer 9.3 UCA1 MIR103A1 GAS5 ERBB2
24 myeloma, multiple 9.2 UCA1 MIR32 MIR196A1 GAS5 ERBB2
25 renal cell carcinoma, nonpapillary 9.2 UCA1 MIR196A1 MIR103A1 GAS5
26 pancreatic cancer 9.2 UCA1 MIR32 MIR196A1 GAS5 ERBB2

Graphical network of the top 20 diseases related to Her2-Receptor Positive Breast Cancer:



Diseases related to Her2-Receptor Positive Breast Cancer

Symptoms & Phenotypes for Her2-Receptor Positive Breast Cancer

Drugs & Therapeutics for Her2-Receptor Positive Breast Cancer

Search Clinical Trials , NIH Clinical Center for Her2-Receptor Positive Breast Cancer

Genetic Tests for Her2-Receptor Positive Breast Cancer

Anatomical Context for Her2-Receptor Positive Breast Cancer

MalaCards organs/tissues related to Her2-Receptor Positive Breast Cancer:

40
Breast

Publications for Her2-Receptor Positive Breast Cancer

Articles related to Her2-Receptor Positive Breast Cancer:

# Title Authors PMID Year
1
Differential impact of hormone receptor status on survival and recurrence for HER2 receptor-positive breast cancers treated with Trastuzumab. 61
28378298 2017
2
Long-term effect of trastuzumab on QT dispersion in adjuvant treatment for patients with Her2 receptor positive breast cancer: a pilot study. 61
22752572 2012

Variations for Her2-Receptor Positive Breast Cancer

Expression for Her2-Receptor Positive Breast Cancer

Search GEO for disease gene expression data for Her2-Receptor Positive Breast Cancer.

Pathways for Her2-Receptor Positive Breast Cancer

Pathways related to Her2-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 MIR32 MIR103A1 ERBB2

GO Terms for Her2-Receptor Positive Breast Cancer

Biological processes related to Her2-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell growth GO:0030307 8.62 ERBB2 ACSL4

Molecular functions related to Her2-Receptor Positive Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 8.8 MIR32 MIR196A1 MIR103A1

Sources for Her2-Receptor Positive Breast Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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