MCID: HRD083
MIFTS: 32

Hereditary Antithrombin Deficiency

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Hereditary Antithrombin Deficiency

MalaCards integrated aliases for Hereditary Antithrombin Deficiency:

Name: Hereditary Antithrombin Deficiency 54 26 74
Antithrombin Iii Deficiency 54 26 74
Congenital Antithrombin Iii Deficiency 54 26
Hereditary Thrombophilia Due to Congenital Antithrombin 3 Deficiency 54
Hereditary Thrombophilia Due to Congenital Antithrombin Deficiency 54
Thrombophilia Due to Antithrombin Iii Deficiency 54
Inherited Antithrombin Deficiency 54
Congenital at-Iii Deficiency 54

Classifications:



External Ids:

Summaries for Hereditary Antithrombin Deficiency

NIH Rare Diseases : 54 Hereditary antithrombin deficiency, also known as antithrombin III deficiency or AT III deficiency, is a disorder in which individuals are at increased risk for developing blood clots. The type of blood clots seen in individuals with this condition are typically clots that form in the deep veins of the leg (deep vein thrombosis or DVT) and clots that lodge in the lungs (pulmonary embolism or PE). Approximately 50% of individuals with hereditary antithrombin deficiency will develop one or more clots in their lifetime, usually after adolescence. Factors that may increase the likelihood of clotting include pregnancy, the use of oral contraceptives, surgery, increasing age, and a lack of movement. Hereditary antithrombin deficiency is caused by mutations in the SERPINC1 gene and is typically inherited in an autosomal dominant manner.

MalaCards based summary : Hereditary Antithrombin Deficiency, also known as antithrombin iii deficiency, is related to hereditary antithrombin deficiency type i and hereditary antithrombin deficiency type 2. An important gene associated with Hereditary Antithrombin Deficiency is SERPINC1 (Serpin Family C Member 1). The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes.

Genetics Home Reference : 26 Hereditary antithrombin deficiency is a disorder of blood clotting. People with this condition are at higher than average risk for developing abnormal blood clots, particularly a type of clot that occurs in the deep veins of the legs. This type of clot is called a deep vein thrombosis (DVT). Affected individuals also have an increased risk of developing a pulmonary embolism (PE), which is a clot that travels through the bloodstream and lodges in the lungs. In hereditary antithrombin deficiency, abnormal blood clots usually form only in veins, although they may rarely occur in arteries.

Related Diseases for Hereditary Antithrombin Deficiency

Diseases related to Hereditary Antithrombin Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 55, show less)
# Related Disease Score Top Affiliating Genes
1 hereditary antithrombin deficiency type i 12.5
2 hereditary antithrombin deficiency type 2 12.3
3 budd-chiari syndrome 11.7
4 antithrombin iii deficiency 11.3
5 thrombophilia due to thrombin defect 10.5
6 pulmonary embolism 10.3
7 nephrotic syndrome 10.3
8 antiphospholipid syndrome 10.1
9 thrombosis 10.1
10 myocardial infarction 10.1
11 leukemia 10.1
12 retinal vein occlusion 10.1
13 atrial fibrillation 10.1
14 ischemia 10.1
15 varicose veins 9.9
16 thrombocytopenia 9.9
17 portal vein thrombosis 9.9
18 thrombophilia 9.9
19 heparin-induced thrombocytopenia 9.9
20 klippel-trenaunay-weber syndrome 9.9
21 systemic lupus erythematosus 9.9
22 ovarian hyperstimulation syndrome 9.9
23 acute promyelocytic leukemia 9.9
24 leukemia, acute lymphoblastic 9.9
25 myelodysplastic syndrome 9.9
26 diabetes mellitus 9.9
27 end stage renal failure 9.9
28 glomerulonephritis 9.9
29 osteonecrosis 9.9
30 livedoid vasculitis 9.9
31 colitis 9.9
32 lymphocytic leukemia 9.9
33 pre-eclampsia 9.9
34 disseminated intravascular coagulation 9.9
35 coronary thrombosis 9.9
36 von willebrand's disease 9.9
37 severe pre-eclampsia 9.9
38 mycoplasma pneumoniae pneumonia 9.9
39 eclampsia 9.9
40 toxic shock syndrome 9.9
41 angioedema 9.9
42 atrial heart septal defect 9.9
43 central retinal vein occlusion 9.9
44 protein s deficiency 9.9
45 sagittal sinus thrombosis 9.9
46 protein c deficiency 9.9
47 thrombophlebitis 9.9
48 intracranial thrombosis 9.9
49 pneumonia 9.9
50 vasculitis 9.9
51 lupus erythematosus 9.9
52 amyloidosis 9.9
53 acquired angioedema 9.9
54 chromosomal triplication 9.9
55 mosaic trisomy 8 9.9

Graphical network of the top 20 diseases related to Hereditary Antithrombin Deficiency:



Diseases related to Hereditary Antithrombin Deficiency

Symptoms & Phenotypes for Hereditary Antithrombin Deficiency

Drugs & Therapeutics for Hereditary Antithrombin Deficiency

Drugs for Hereditary Antithrombin Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 27, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
2
Dalteparin Approved Phase 4 9005-49-6
3
Enoxaparin Approved Phase 4 9005-49-6 772
4
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
5
tannic acid Approved Phase 4,Phase 3 1401-55-4
6
Serine Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 56-45-1 5951
7
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
8 calcium heparin Phase 4
9 Fibrinolytic Agents Phase 4
10 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
11 Heparin, Low-Molecular-Weight Phase 4
12 Antithrombin III Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
13 Antithrombins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
14
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
15 Serine Proteinase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Calcium, Dietary Phase 4
18
Thrombin Approved, Investigational Phase 2, Phase 3,Early Phase 1
19 Vaccines Phase 3
20 Anesthetics Phase 2
21 Coagulants Phase 2
22 Hemostatics Phase 2
23
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
24 Antibodies
25 Antibodies, Antiphospholipid
26 Immunologic Factors
27 Immunoglobulins

Interventional clinical trials:

(showing 18, show less)
# Name Status NCT ID Phase Drugs
1 Low Molecular Weight Heparin in Prevention of Recurrent Arteriovenous Graft Thrombosis in Chronic Hemodialysis Patients. Unknown status NCT01970280 Phase 4 Enoxaparin
2 Response of Recombinant Antithrombin in Heparin Resistant Patients Undergoing Cardiac Surgery Terminated NCT01547728 Phase 4 Recombinant antithrombin (rhAT)
3 Atenativ Effect on Uterine Blood Flow and Preeclampsia Withdrawn NCT02278575 Phase 4 Atenativ
4 Pharmacokinetic Study of Recombinant AT III in Neonates Undergoing ECMO Withdrawn NCT01913444 Phase 4 Recombinant Antithrombin
5 Recombinant Human Antithrombin (rhAT) in Patients With Hereditary Antithrombin Deficiency Undergoing Surgery or Delivery Completed NCT00110513 Phase 3
6 Assess Incidence of Deep Vein Thrombosis(DVT)Following Administration of Recombinant Human Antithrombin (rhAT) to Hereditary Antithrombin(AT) Deficient Patients in High Risk Situations. Completed NCT00056550 Phase 3
7 Safety, Pharmacokinetics and Efficacy of an AT-III Concentrate. Active, not recruiting NCT00319228 Phase 2, Phase 3 Plasma-derived AT-III concentrate
8 Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass Completed NCT00823082 Phase 2 Antithrombin III
9 Anti-thrombin III (ATIII) vs Placebo in Children (<7mo) Undergoing Open Congenital Cardiac Surgery Completed NCT02103114 Phase 2 Anti-thrombin III
10 A Study of KW-3357 in Congenital Antithrombin Deficiency Completed NCT00938288 Phase 1 KW-3357
11 Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support Completed NCT02631174 Phase 1 Antithrombin III
12 "Incidence and Consequences of Disorders of Glycosylation in Patients With Conotruncal and Septal Heart Defects" Unknown status NCT02503267
13 Effects of Combined Resistance and Aerobic Training vs Aerobic Training on Cognition and Mobility Following Stroke Completed NCT01712724 Not Applicable
14 Staphylococcus Aureus Bacteremia: Impact of an Intervention Program in Improving the Clinical Management and Review of the Clinical and Molecular Epidemiology Completed NCT01971762
15 Antiphospholipid Antibodies & Osteopontin as Risk Factors for Cerebrovascular Stroke in Young Adults Recruiting NCT03561285
16 The 3D Reconstruction Research of Pelvic Organ Prolapse Disease Recruiting NCT03146195
17 Is There an Interaction Between Recurrent Miscarriage and Dental Health Recruiting NCT03577314
18 Response of Continuous Recombinant Antithrombin Infusion in Postcardiotomy ECMO Patients Withdrawn NCT03090893 Early Phase 1 ATryn continuous infusion

Search NIH Clinical Center for Hereditary Antithrombin Deficiency

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Hereditary Antithrombin Deficiency

Anatomical Context for Hereditary Antithrombin Deficiency

MalaCards organs/tissues related to Hereditary Antithrombin Deficiency:

42
Lung, Heart, Testes, Myeloid, Whole Blood

Publications for Hereditary Antithrombin Deficiency

Articles related to Hereditary Antithrombin Deficiency:

(showing 266, show less)
# Title Authors Year
1
A case report of atrial fibrillation in a patient with heparin resistance associated with an antithrombin III deficiency successfully treated by radiofrequency catheter ablation using a direct thrombin inhibitor. ( 31020242 )
2019
2
SERPINC1 variants causing hereditary antithrombin deficiency in a Danish population. ( 30721820 )
2019
3
Portal Vein Thrombosis in a Patient with Hereditary Antithrombin Deficiency. ( 30799362 )
2019
4
Efficacy and safety of apixaban in a patient with systemic venous thromboembolism associated with hereditary antithrombin deficiency. ( 30949252 )
2019
5
Strategy for Cardiovascular Surgery in Patients with Antithrombin III Deficiency. ( 29681597 )
2018
6
Association of hereditary antithrombin deficiency with intrauterine growth restriction. ( 29889663 )
2018
7
β-Antithrombin, subtype of antithrombin deficiency and the risk of venous thromboembolism in hereditary antithrombin deficiency: A family cohort study. ( 29902631 )
2018
8
Proper diagnosis of antithrombin III deficiency. ( 28466833 )
2017
9
Familial antithrombin III deficiency in a Malay patient with massive thrombosis. ( 28866705 )
2017
10
Successful treatment of a massive pulmonary embolism using rivaroxaban in a patient with antithrombin III deficiency. ( 30279820 )
2017
11
Management of Venous Thromboembolism in Patients with Hereditary Antithrombin Deficiency and Pregnancy: Case Report and Review of the Literature. ( 28168066 )
2017
12
Management of hereditary antithrombin deficiency in pregnancy. ( 28689083 )
2017
13
Edoxaban Was Effective for the Treatment of Deep Vein Thrombosis and Pulmonary Thromboembolism in a Cancer Patient with Antithrombin III Deficiency. ( 27853070 )
2016
14
Antithrombin III deficiency concomitant with atrial fibrillation causes thrombi in all chambers: 2D and 3D echocardiographic evaluation. ( 28005013 )
2016
15
Recombinant Human Antithrombin in Pregnant Patients with Hereditary Antithrombin Deficiency: Integrated Analysis of Clinical Data. ( 26461927 )
2016
16
Issues in the Diagnosis and Management of Hereditary Antithrombin Deficiency. ( 27281301 )
2016
17
Congenital atresia of the inferior vena cava and antithrombin III deficiency in a young adult: compounding risk factors for deep vein thrombosis. ( 25628315 )
2015
18
Antithrombin III deficiency in Indian patients with deep vein thrombosis: identification of first India based AT variants including a novel point mutation (T280A) that leads to aggregation. ( 25811371 )
2015
19
Hereditary antithrombin III deficiency and neuraxial anaesthesia. ( 26603805 )
2015
20
Portal vein thrombosis after aortic valve replacement surgery in a patient with antithrombin III deficiency--case presentation. ( 24775062 )
2014
21
Prevention, management and extent of adverse pregnancy outcomes in women with hereditary antithrombin deficiency. ( 23999648 )
2014
22
Impact of the type of SERPINC1 mutation and subtype of antithrombin deficiency on the thrombotic phenotype in hereditary antithrombin deficiency. ( 24196373 )
2014
23
Pharmacokinetics of recombinant human antithrombin in delivery and surgery patients with hereditary antithrombin deficiency. ( 24335249 )
2014
24
Perioperative and peripartum prevention of venous thromboembolism in patients with hereditary antithrombin deficiency using recombinant antithrombin therapy. ( 24686101 )
2014
25
Surgical treatment of atrial septal defect in a patient with familial antithrombin-III deficiency. ( 23232305 )
2013
26
A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failure. ( 24164998 )
2013
27
Acute coronary syndrome in a young woman with antithrombin III deficiency. ( 30533135 )
2013
28
Prevention and treatment of venous thromboembolism in pregnancy in patients with hereditary antithrombin deficiency. ( 23662090 )
2013
29
Quite a backup: pericardial varices in a patient with hereditary antithrombin deficiency. ( 23833730 )
2013
30
How I treat heterozygous hereditary antithrombin deficiency in pregnancy. ( 23903049 )
2013
31
Argatroban therapy for heparin-induced thrombocytopenia during pregnancy in a woman with hereditary antithrombin deficiency. ( 22380425 )
2012
32
Early graft thrombosis due to antithrombin III deficiency following CABG. ( 21327876 )
2011
33
Surgical thromboembolectomy for a massive pulmonary embolism after several venous thromboembolic episodes caused by congenital antithrombin III deficiency. ( 22051999 )
2011
34
A heparin binding site Arg79Cys missense mutation in the SERPINC1 gene in a Korean patient with hereditary antithrombin deficiency. ( 21325262 )
2011
35
Successful pulmonary embolectomy in a 4-year-old girl with antithrombin III deficiency. ( 20143056 )
2010
36
Neuraxial anesthesia for labor and cesarean delivery in a parturient with hereditary antithrombin deficiency on recombinant human antithrombin infusion therapy. ( 20868967 )
2010
37
Simultaneous thromboses of double coronary arteries in a young male with antithrombin III deficiency. ( 19931780 )
2009
38
Role of antithrombin concentrate in treatment of hereditary antithrombin deficiency. An update. ( 19404531 )
2009
39
Acquired angioedema associated with primary antiphospholipid syndrome in a patient with antithrombin III deficiency. ( 18204284 )
2008
40
Intrapartum placement of an inferior vena cava filter for a woman with hereditary antithrombin III deficiency: its role in the prevention of fatal pulmonary embolism. ( 18226138 )
2008
41
A model for the formation, growth, and lysis of clots in quiescent plasma. A comparison between the effects of antithrombin III deficiency and protein C deficiency. ( 18539301 )
2008
42
Recurrent myocardial infarction in a young football player with antithrombin III deficiency. ( 18810723 )
2008
43
Multiple isolated sinus dural arteriovenous fistulas associated with antithrombin III deficiency--case report--. ( 18948680 )
2008
44
Detection of large deletion mutations in the SERPINC1 gene causing hereditary antithrombin deficiency by multiplex ligation-dependent probe amplification (MLPA). ( 18208532 )
2008
45
Superior mesenteric and portal vein thrombosis caused by congenital antithrombin III deficiency: report of a case. ( 17387563 )
2007
46
Vena cava superior syndrome developing in a dialysis patient with antithrombin III deficiency following temporary catheterization. ( 16429847 )
2006
47
Portal, splenic and mesenteric vein thrombosis in a patient with factor V Leiden mutation and antithrombin III deficiency. ( 16525787 )
2006
48
Constitutional trisomy 8 mosaicism with myelodysplastic syndrome complicated by intestinal Behcet disease and antithrombin III deficiency. ( 16213367 )
2005
49
The prevalence of protein C, protein S, and antithrombin III deficiency in non-APS/SLE Chinese adults with noncardiac cerebral ischemia. ( 12812386 )
2003
50
Pulmonary thromboembolectomy in congenital antithrombin III deficiency associated with acute pulmonary embolism -report of a case-. ( 12875643 )
2003
51
Mesenteric venous thrombosis in a patient with prothrombin 20210A mutation and antithrombin III deficiency: challenges to conventional anticoagulation--a case report. ( 12894373 )
2003
52
Effects of argatroban as an anticoagulant for haemodialysis in patients with antithrombin III deficiency. ( 12897104 )
2003
53
Budd-Chiari syndrome due to antithrombin III deficiency. ( 14719794 )
2003
54
Antithrombin III deficiency. ( 17827598 )
2003
55
Livedoid vasculitis with ulcerations: the role of antithrombin III deficiency and its therapeutic consequences. ( 12056979 )
2002
56
Budd-Chiari syndrome and extrahepatic portal obstruction associated with congenital antithrombin III deficiency. ( 11388398 )
2001
57
Intracranial venous thrombosis associated with severe antithrombin-III deficiency in pregnancy. ( 11396643 )
2001
58
Severe preeclampsia in antithrombin III deficiency with no history of venous thromboembolism. ( 11506257 )
2001
59
Management of pregnancy with congenital antithrombin III deficiency: two case reports and a review of the literature. ( 11721729 )
2001
60
A patient defines the interstitial 1q deletion syndrome characterized by antithrombin III deficiency. ( 11754060 )
2001
61
Successful use of argatroban as an anticoagulant in burn-related severe acquired antithrombin III deficiency after heparin failure. ( 11776342 )
2001
62
Anticoagulation management in a patient with an acquired antithrombin III deficiency. ( 11806438 )
2001
63
[Olav Egeberg--hereditary antithrombin deficiency and thrombophilia]. ( 11301618 )
2001
64
Acute arterial thrombosis with antithrombin III deficiency in nephrotic syndrome: report of a case. ( 10930236 )
2000
65
Antithrombin III deficiency in a patient with multifocal osteonecrosis. ( 10987006 )
2000
66
Familial antithrombin-III deficiency during cardiopulmonary bypass: a case report. ( 11131221 )
2000
67
Congenital antithrombin III deficiency in pregnancy treated with low-molecular-weight heparin. ( 15512479 )
2000
68
A case of ovarian hyperstimulation syndrome in which antithrombin III deficiency occurred because of its loss into ascites. ( 10231046 )
1999
69
Plasma antithrombin III deficiency in ischaemic stroke in the young. ( 10402346 )
1999
70
Deep vein thrombosis after hemolytic crisis in a glucose-6-phosphate dehydrogenase deficient boy with antithrombin-III deficiency. ( 27605287 )
1999
71
A novel splice site mutation in a Brazilian patient with hereditary antithrombin deficiency type I. ( 10077734 )
1999
72
Chronic pulmonary thromboendarterectomy complicated by antithrombin III deficiency and antiphospholipid syndrome. ( 9884556 )
1998
73
A case report of heparin resistance due to acquired antithrombin III deficiency. ( 10101569 )
1998
74
[Hereditary antithrombin deficiency and pregnancy. Pregnancy course in six women with known hereditary antithrombin deficiency]. ( 9850619 )
1998
75
Acquired protein S and antithrombin III deficiency caused by nephrotic syndrome: an unusual cause of graft thrombosis. ( 9081142 )
1997
76
Index of suspicion. Case 3. Antithrombin III deficiency. ( 9255997 )
1997
77
Coronary thrombosis associated with antithrombin-III deficiency. ( 9327319 )
1997
78
Indicators of fibrinolysis during cardiopulmonary bypass after exogenous antithrombin-III administration for acquired antithrombin III deficiency. ( 9327320 )
1997
79
Aortic thrombosis in a neonate with hereditary antithrombin III deficiency: successful outcome with thrombolytic and replacement treatment. ( 8640060 )
1996
80
Analysis for antithrombin gene polymorphisms in Japanese subjects and cosegregation studies in families with hereditary antithrombin deficiency. ( 8732631 )
1996
81
Acute promyelocytic leukemia developed in a patient with congenital antithrombin III deficiency. ( 7718768 )
1995
82
Antithrombin III deficiency as a risk factor for catheter-related central vein thrombosis in cancer patients. ( 7482430 )
1995
83
Epidural caesarean section in a patient with congenital antithrombin III deficiency. ( 7485945 )
1995
84
Portal vein thrombosis due to antithrombin III deficiency. A case report. ( 7486227 )
1995
85
Catastrophic secondary antiphospholipid syndrome with concomitant antithrombin III deficiency. ( 7620085 )
1995
86
Massive deep vein thrombosis in a patient with antithrombin III deficiency undergoing ovarian stimulation for in vitro fertilization. ( 7851607 )
1995
87
Antithrombin III deficiency, deep venous thrombosis, and oral contraceptive use. ( 8519788 )
1995
88
Use of antithrombin III concentrates to correct antithrombin III deficiency during vascular surgery. ( 8523616 )
1995
89
Antithrombin III deficiency during continuous venovenous hemodialysis. ( 8529370 )
1995
90
Antithrombin III deficiency. ( 7920326 )
1994
91
Detection of multiple thromboembolism in congenital antithrombin III deficiency with indium-111-platelet scintigraphy. ( 7965163 )
1994
92
Homozygous or compound heterozygous qualitative antithrombin III deficiency. ( 7971256 )
1994
93
Venous surgery in patients with congenital antithrombin III deficiency. ( 7980265 )
1994
94
Inherited antithrombin III deficiency in the neonate. ( 8148939 )
1994
95
Prothrombin fragment 1 + 2, thrombin-antithrombin III-complexes and fibrinopeptide A in spontaneously clotting whole blood in vitro. Effects of heparin addition and antithrombin III deficiency. ( 8165646 )
1994
96
Antithrombin III deficiency in neonatal respiratory distress syndrome. ( 8186352 )
1994
97
Acquired antithrombin III deficiency secondary to asparaginase therapy in childhood acute lymphoblastic leukaemia. ( 8186353 )
1994
98
Acquired antithrombin III deficiency--rationale for replacement therapy. Introduction and overview--what are the questions? ( 8186354 )
1994
99
Antithrombin III replacement in animal models of acquired antithrombin III deficiency. ( 8186355 )
1994
100
Increased endogenous thrombin generation in children with acute lymphoblastic leukemia: risk of thrombotic complications in L'Asparaginase-induced antithrombin III deficiency. ( 8286739 )
1994
101
Hereditary antithrombin deficiency: heterogeneity of the molecular basis and mortality in Dutch families. ( 7994035 )
1994
102
Venous thrombosis: antithrombin III deficiency. ( 8217045 )
1993
103
Overtight nappy precipitating thrombosis in antithrombin III deficiency. ( 8257185 )
1993
104
Acquired antithrombin III deficiency: replacement with antithrombin III concentrates in a patient with protein S deficiency accelerates response to therapy. ( 8291376 )
1993
105
Are oral contraceptives a more important risk factor than pregnancy in women with congenital antithrombin III deficiency? ( 8292733 )
1993
106
Cerebral vein thrombosis due to hereditary antithrombin III deficiency. ( 8334580 )
1993
107
Myocardial infarction in a neonate with hereditary antithrombin III deficiency. ( 8339004 )
1993
108
Heparin therapy for congenital antithrombin III deficiency in pregnancy. ( 8397570 )
1993
109
Obstetrical analgesia in a parturient with antithrombin III deficiency. ( 8403113 )
1993
110
An antithrombin III assay based on factor Xa inhibition provides a more reliable test to identify congenital antithrombin III deficiency than an assay based on thrombin inhibition. ( 8470046 )
1993
111
Perioperative management of a patient with congenital antithrombin III deficiency. ( 15278504 )
1993
112
Two new nonsense mutations in type Ia antithrombin III deficiency at Leu 140 and Arg 197. ( 1360174 )
1992
113
Deep venous thrombosis and pulmonary embolism in a patient with type III von Willebrand's disease, protein C and antithrombin III deficiency. ( 1390220 )
1992
114
Thrombosis in antithrombin-III deficiency. ( 1416567 )
1992
115
Antithrombin III deficiency and cerebrovascular accidents in young adults. ( 1430264 )
1992
116
Prophylactic antithrombin III administration during pregnancy immediately reduces the thrombin hyperactivity of congenital antithrombin III deficiency by forming thrombin-antithrombin III complexes. ( 1523607 )
1992
117
Recurrent renal vein thrombosis and renal failure associated with antithrombin-III deficiency. ( 1571206 )
1992
118
Congenital antithrombin III deficiency causing mesenteric venous infarction: a lesson to remember--a case history. ( 1626742 )
1992
119
Mortality related to thrombosis in congenital antithrombin III deficiency. ( 1675390 )
1991
120
The transient increase of plasma thrombin-antithrombin III (TAT) complex levels in patients with congenital antithrombin III deficiency during antithrombin III administration is due to extraction of thrombin from fibrin. ( 1755000 )
1991
121
Cerebral venous thrombosis associated with antithrombin III deficiency. ( 1759929 )
1991
122
Congenital antithrombin III deficiency (AT-III Kyoto): identification of a point mutation altering arginine-406 to methionine behind the reactive site. ( 1776135 )
1991
123
A common point mutation producing type 1A antithrombin III deficiency: AT129 CGA to TGA (Arg to Stop). ( 1808766 )
1991
124
Familial antithrombin III deficiency and Mycoplasma pneumoniae pneumonia. ( 1960224 )
1991
125
Mortality in hereditary antithrombin-III deficiency--1830 to 1989. ( 1671110 )
1991
126
Mortality related to thrombosis in congenital antithrombin III deficiency. ( 1672929 )
1991
127
Effective prophylaxis of thrombosis by antithrombin III concentrate in a pregnant woman with congenital antithrombin III deficiency: relations between plasma antithrombin III activity and the plasma levels of hemostatic molecular markers. ( 1773985 )
1991
128
Clinical aspects of antithrombin III deficiency. ( 2017687 )
1991
129
Replacement therapy in patients with hereditary antithrombin III deficiency. ( 2017690 )
1991
130
Pregnancy, antithrombin III deficiency and venous thrombosis: report of another case. ( 2106195 )
1990
131
Emergency treatment with recombinant tissue plasminogen activator of pulmonary embolism in a pregnant woman with antithrombin III deficiency. ( 2121034 )
1990
132
Danazol therapy in familial antithrombin III deficiency. ( 2272164 )
1990
133
Occult antithrombin III deficiency: a potentially lethal complication of the postphlebitic limb. ( 2325220 )
1990
134
Hereditary antithrombin III deficiency with a superior sagittal sinus thrombosis: evidence for a possible mutation starting in the mother of the propositus. ( 2326775 )
1990
135
Premature arterial disease associated with familial antithrombin III deficiency. ( 2339350 )
1990
136
Antithrombin-III deficiency in ischemic stroke. ( 2349602 )
1990
137
Elimination of antithrombin III concentrate in healthy pregnant and preeclamptic women with an acquired antithrombin III deficiency. ( 2353344 )
1990
138
Evaluation of the safety, recovery, half-life, and clinical efficacy of antithrombin III (human) in patients with hereditary antithrombin III deficiency. Cooperative Study Group. ( 2403821 )
1990
139
Replacement therapy in antithrombin III deficiency. ( 2520559 )
1989
140
The molecular pathology of inherited human antithrombin III deficiency. ( 2520560 )
1989
141
Prophylaxis during surgery in antithrombin III deficiency with low dose of concentrates. ( 2617483 )
1989
142
Congenital antithrombin III deficiency. Incidence and clinical features. ( 2679068 )
1989
143
Congenital antithrombin III deficiency: insights into the pathogenesis of the hypercoagulable state and its management using markers of hemostatic system activation. ( 2679069 )
1989
144
Acquired antithrombin III deficiency: laboratory diagnosis, incidence, clinical implications, and treatment with antithrombin III concentrate. ( 2679070 )
1989
145
Neonatal antithrombin III deficiency. ( 2679071 )
1989
146
Surgery in patients with congenital antithrombin III deficiency. ( 2453983 )
1988
147
Mechanisms of the development of acquired antithrombin III deficiency in the experimental nephrotic syndromes. ( 2465224 )
1988
148
Antithrombin III deficiency. ( 3061530 )
1988
149
Bilateral ileofemoral thrombophlebitis after ten contraceptive pills in a 25-year-old woman with antithrombin III deficiency. ( 3124473 )
1988
150
Oxymetholone therapy in patients with familial antithrombin III deficiency. ( 3238652 )
1988
151
Posterior aortic thrombosis secondary to glomerulonephritis and acquired antithrombin III deficiency. ( 3258691 )
1988
152
Pathophysiology of antithrombin III deficiency. ( 3282388 )
1988
153
Mesenteric venous thrombosis due to antithrombin III deficiency. ( 3337617 )
1988
154
Antithrombin III microheterogeneity in antithrombin III deficiency and in the antithrombin III abnormality, "antithrombin III Toyama". ( 3116713 )
1987
155
Different prevalence of thromboembolism in the subtypes of congenital antithrombin III deficiency: review of 404 cases. ( 3328320 )
1987
156
Cerebral thromboembolism due to antithrombin III deficiency in two children. ( 3561706 )
1987
157
Prophylactic use of antithrombin III concentrate following surgery in congenital antithrombin III deficiency. ( 3581714 )
1987
158
Antithrombin III deficiency with negative family history. ( 3581721 )
1987
159
Antithrombin III deficiency: clinical relevance and replacement therapy. ( 3609485 )
1987
160
Mesenteric venous thrombosis and antithrombin III deficiency. ( 3654990 )
1987
161
Molecular genetic survey of 16 kindreds with hereditary antithrombin III deficiency. ( 3663935 )
1987
162
Extensive thrombus formation with heparin resistance during extracorporeal circulation. A new presentation of familial antithrombin III deficiency. ( 3800516 )
1987
163
Antithrombin III deficiency as congenital risk factor for venous thrombosis and embolism. ( 3096837 )
1986
164
Thrombophilia caused by primary antithrombin-III deficiency. Report of an autopsy case. ( 3105980 )
1986
165
Antithrombin III concentrate. Thromboprophylaxis during pregnancy in a patient with congenital antithrombin III deficiency. ( 3739652 )
1986
166
Arterial thrombosis in antithrombin III deficiency. ( 3757457 )
1986
167
Hereditary antithrombin III deficiency in a Korean family. ( 3766082 )
1986
168
Hereditary antithrombin III deficiency: case report and review of recent therapeutic advances. ( 3942133 )
1986
169
Antithrombin III deficiency: a report of 14 cases belonging to three different kindreds. ( 2414189 )
1985
170
Congenital and acquired antithrombin III deficiency. ( 3836551 )
1985
171
Familial antithrombin III deficiency. ( 3859772 )
1985
172
Acquired factor X and antithrombin III deficiency in a patient with primary amyloidosis and nephrotic syndrome. ( 3876596 )
1985
173
Unusual widespread arterial involvement in hereditary antithrombin III deficiency. ( 3924768 )
1985
174
Inherited antithrombin III deficiency in an Italian family, associated with venous and arterial thrombosis. ( 3937775 )
1985
175
Antithrombin III deficiency: an etiology of Budd-Chiari syndrome. ( 3969629 )
1985
176
Antithrombin III metabolism in two colitis patients with acquired antithrombin III deficiency. ( 4007429 )
1985
177
Treatment of familial antithrombin-III deficiency with danazol. ( 4007636 )
1985
178
Hereditary antithrombin III deficiency and pregnancy: report of two cases and review of the literature. ( 4039808 )
1985
179
Prevalence of antithrombin III deficiency in blood donors selected for personal or familial history of venous thrombosis. ( 4059797 )
1985
180
Effect of danazol on the biochemical abnormality of inherited antithrombin III deficiency. ( 4060104 )
1985
181
The prevalence of hereditary antithrombin-III deficiency in patients with a history of venous thromboembolism. ( 4089808 )
1985
182
Acute aortic thrombosis and antithrombin III deficiency in the nephrotic syndrome: a case report. ( 15227011 )
1985
183
Hereditary antithrombin III deficiency and venous thrombosis. ( 6379481 )
1984
184
Heparin cofactor II determination--levels in normals and patients with hereditary antithrombin III deficiency and disseminated intravascular coagulation. ( 6395434 )
1984
185
Thrombosis of an aortic porcine xenobioprosthesis associated with familial antithrombin III deficiency. ( 6482495 )
1984
186
Antithrombin III deficiency as a reflection of dynamic protein metabolism in patients undergoing vascular reconstruction. ( 6492312 )
1984
187
Antithrombin III deficiency in Nigerian sicklers--possible predisposition to thrombotic crises. ( 6545202 )
1984
188
Acute myeloid leukaemia in a patient with congenital antithrombin III deficiency. ( 6589236 )
1984
189
Management of planned pregnancy in a patient with congenital antithrombin III deficiency. ( 6691921 )
1984
190
Antithrombin III deficiency in a Romanian family. Pathogenic role of concomitantly increased plasma level of clotting factors VII and X. ( 6710043 )
1984
191
Hereditary antithrombin III deficiency: biochemical aspects. ( 6724355 )
1984
192
Antithrombin III deficiency: clinical aspects. ( 6724356 )
1984
193
Prophylactic antithrombotic therapy with stanozolol in patients with familial antithrombin III deficiency. ( 6743570 )
1984
194
Persistent antithrombin III deficiency: risk factor for thromboembolic complications in neonates small for gestational age. ( 6747767 )
1984
195
Treatment of antithrombin III deficiency with danazol. ( 6749234 )
1984
196
Familial antithrombin III deficiency. ( 6133063 )
1983
197
Heparin cofactor activities in a family with hereditary antithrombin III deficiency: evidence for a second heparin cofactor in human plasma. ( 6184096 )
1983
198
Factors influencing thrombosis in familial antithrombin III deficiency. ( 6186268 )
1983
199
Molecular heterogeneity of inherited antithrombin III deficiency. ( 6304514 )
1983
200
Fatal pulmonary embolism and antithrombin III deficiency in adult lymphoblastic leukaemia during L-asparaginase therapy. ( 6404103 )
1983
201
False assignment of familial antithrombin III deficiency with the von Kaulla assay. ( 6416053 )
1983
202
Severe acquired antithrombin III deficiency in relation to hepatic and renal insufficiency and intrauterine fetal death in late pregnancy. ( 6618278 )
1983
203
Molecular heterogeneity of inherited antithrombin III deficiency. ( 6621648 )
1983
204
Clinical and genetic aspects of antithrombin III deficiency. ( 6846404 )
1983
205
L-asparaginase induced antithrombin III deficiency: evidence against the production of a hypercoagulable state. ( 6857592 )
1983
206
An acquired antithrombin III deficiency in the course of toxic shock syndrome after elective orthopaedic surgery. ( 6866173 )
1983
207
Antithrombin III deficiency in ischaemic stroke. ( 6876691 )
1983
208
Familial antithrombin III deficiency: its natural history, genetics, diagnosis and treatment. ( 6877092 )
1983
209
Arterial thromboembolism and associated antithrombin III deficiency. ( 6879278 )
1983
210
Recurrent arterial and venous thrombosis due to an acquired antithrombin III deficiency? ( 6815019 )
1982
211
Hypercoagulable state in three dogs with nephrotic syndrome: role of acquired antithrombin III deficiency. ( 6815144 )
1982
212
Aortic thrombosis in antithrombin III deficiency. ( 7057600 )
1982
213
Treatment of congenital antithrombin III deficiency with concentrates. ( 7066204 )
1982
214
Antithrombin III deficiency: decreased synthesis of a biochemically normal molecule. ( 7082848 )
1982
215
Congenital antithrombin III deficiency. A description of two Belgian families. Therapeutic implications. ( 7090706 )
1982
216
Arterial thrombosis and accelerated atheroma in a member of a family with familial antithrombin III deficiency. ( 7100022 )
1982
217
Budd-Chiari Syndrome and antithrombin III deficiency. ( 7102823 )
1982
218
Pregnancy in women with congenital antithrombin III deficiency: experience of treatment with heparin and antithrombin. ( 7117919 )
1982
219
The clinical significance of antithrombin III deficiency. ( 7153810 )
1982
220
Familial antithrombin III deficiency. ( 7156320 )
1982
221
Antithrombin III deficiency in an Indian family. ( 7179213 )
1982
222
Antithrombin III concentrate: its catabolism in health and in antithrombin III deficiency. ( 7031840 )
1981
223
Antithrombin III deficiency appearing as mesenteric vein thrombosis. ( 7331986 )
1981
224
Incidence of thrombosis in inherited antithrombin III deficiency. ( 7344175 )
1981
225
Antithrombin III deficiency and thromboembolism. ( 7032781 )
1981
226
Surgical implications of antithrombin III deficiency. ( 7209791 )
1981
227
Acute aortic thrombosis in antithrombin III deficiency. ( 7218490 )
1981
228
Acquired antithrombin III deficiency and systemic lupus erythematosus. ( 7224694 )
1981
229
Antithrombin III deficiency in surgical intensive care patients. ( 7233404 )
1981
230
Antithrombin III deficiency in a Chinese family. ( 7254014 )
1981
231
Hereditary antithrombin III deficiency in an English family. ( 7470393 )
1981
232
Termination of pregnancy in a woman with hereditary antithrombin deficiency under antithrombotic protection with subcutaneous heparin and infusion of plasma. ( 7262640 )
1981
233
Antithrombin III deficiency during asparaginase therapy. ( 6102228 )
1980
234
Antithrombin III deficiency during asparaginase therapy. ( 6102647 )
1980
235
Thrombin generation and formation of thrombin-antithrombin III complexes in congenital antithrombin III deficiency. ( 7209877 )
1980
236
Inherited antithrombin III deficiency and cerebral thrombosis in a child. ( 7355006 )
1980
237
Familial functional antithrombin III deficiency. ( 7375809 )
1980
238
Inferior vena cava thrombosis in a child with familial antithrombin III deficiency. ( 7404484 )
1980
239
A South African family with antithrombin III deficiency. ( 7423286 )
1980
240
Familial thrombosis associated with antithrombin III deficiency in a young adult male. A case report. ( 7423287 )
1980
241
Antithrombin III deficiency in an Australian family. ( 7426446 )
1980
242
Severe antithrombin III deficiency in a patient with pre-eclampsia. Observations on the effect of human AT III concentrate transfusion. ( 7444377 )
1980
243
Heterogeneity of the "classical" antithrombin III deficiency. ( 7455972 )
1980
244
Primary mesenteric vein thrombosis associated with antithrombin III deficiency. ( 490833 )
1979
245
Familial antithrombin III deficiency in a Japanese family. ( 524322 )
1979
246
Central retinal vein occlusion in a patient with familial antithrombin III deficiency: case report. ( 576075 )
1979
247
Subcutaneous heparin for thrombosis in pregnant women with hereditary antithrombin deficiency. ( 84100 )
1979
248
Familial antithrombin III deficiency. ( 626859 )
1978
249
Antithrombin III deficiency, hypertriglyceridaemia, and venous thromboses. ( 630261 )
1978
250
Acquired antithrombin III deficiency in patients with glomerular proteinuria. ( 689489 )
1978
251
Thrombotic tendency and probable antithrombin III deficiency. ( 705707 )
1978
252
Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome. ( 707521 )
1978
253
Familial antithrombin III deficiency as pathogenesis of deep venous thrombosis. ( 735880 )
1978
254
Antithrombin III deficiency in diabetes mellitus: influence on vascular degenerative complications. ( 744566 )
1978
255
Linkage relationships of dominant antithrombin III deficiency and the heterochromatic region of chromosome 1. ( 752496 )
1978
256
Antithrombin III deficiency causing postsplenectomy mesenteric venous thrombosis coincident with thrombocytopenia. ( 65157 )
1977
257
Familial thrombosis due to antithrombin III deficiency in a Greek family. ( 65891 )
1977
258
Venous thrombosis, heparin-induced antithrombin III deficiency, and factor VIII. ( 73932 )
1977
259
Familial antithrombin III deficiency. An important clinical entity. ( 910096 )
1977
260
Prophylactic and therapeutic use of anticoagulants in inherited antithrombin III deficiency. ( 63150 )
1976
261
Severe antithrombin III deficiency in an infant associated with multiple arterial and venous thromboses. ( 65797 )
1976
262
Hereditary antithrombin III deficiency and thromboembolic disease. ( 826156 )
1976
263
Hereditary antithrombin III deficiency. Effect of antithrombin III deficiency on platelet function. ( 952292 )
1976
264
Inherited antithrombin-III deficiency causing mesenteric venous infarction: a new clinical entity. ( 1138628 )
1975
265
Proceedings: Inherited antithrombin III deficiency and thrombo-embolism. ( 1188834 )
1975
266
Proceedings: The significance of the chronic anticoagulant treatment in recurrent thromboembolie caused by hereditary antithrombin III deficiency. ( 1188835 )
1975

Variations for Hereditary Antithrombin Deficiency

Expression for Hereditary Antithrombin Deficiency

Search GEO for disease gene expression data for Hereditary Antithrombin Deficiency.

Pathways for Hereditary Antithrombin Deficiency

GO Terms for Hereditary Antithrombin Deficiency

Sources for Hereditary Antithrombin Deficiency

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