MCID: HRD215
MIFTS: 24

Hereditary Gastric Cancer

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Hereditary Gastric Cancer

MalaCards integrated aliases for Hereditary Gastric Cancer:

Name: Hereditary Gastric Cancer 58
Hereditary Cancer of Stomach 58

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Orphanet 58 ORPHA423776

Summaries for Hereditary Gastric Cancer

MalaCards based summary : Hereditary Gastric Cancer, also known as hereditary cancer of stomach, is related to gastric adenocarcinoma and gastric cancer, hereditary diffuse. An important gene associated with Hereditary Gastric Cancer is CD44 (CD44 Molecule (Indian Blood Group)), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. The drugs Trastuzumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and tongue.

Related Diseases for Hereditary Gastric Cancer

Diseases in the Gastric Cancer family:

Hereditary Gastric Cancer

Diseases related to Hereditary Gastric Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 gastric adenocarcinoma 29.1 CDH1 CD44
2 gastric cancer, hereditary diffuse 11.7
3 gastric cancer 10.4
4 diffuse gastric cancer 10.2
5 signet ring cell adenocarcinoma 9.9
6 polyposis, gastric 9.8
7 polyposis of gastric fundus without polyposis coli 9.8
8 microinvasive gastric cancer 9.8
9 lynch syndrome 9.8
10 linitis plastica 9.8
11 gastric adenocarcinoma and proximal polyposis of the stomach 9.8
12 luminal breast carcinoma 9.8 CDH1 CD44
13 pre-malignant neoplasm 9.8 CDH1 CD44
14 ovary adenocarcinoma 9.7 CDH1 CD44
15 tongue cancer 9.7 CDH1 CD44
16 ductal carcinoma in situ 9.7 CDH1 CD44
17 malignant ovarian surface epithelial-stromal neoplasm 9.7 CDH1 CD44
18 ovary epithelial cancer 9.7 CDH1 CD44
19 papillary carcinoma 9.7 CDH1 CD44
20 laryngeal squamous cell carcinoma 9.7 CDH1 CD44
21 squamous cell carcinoma 9.7 CDH1 CD44
22 colorectal adenocarcinoma 9.7 CDH1 CD44
23 breast ductal carcinoma 9.7 CDH1 CD44
24 tongue squamous cell carcinoma 9.7 CDH1 CD44
25 transitional cell carcinoma 9.7 CDH1 CD44
26 suppression of tumorigenicity 12 9.7 CDH1 CD44
27 cholangiocarcinoma 9.7 CDH1 CD44
28 pancreatic ductal adenocarcinoma 9.7 CDH1 CD44
29 gallbladder cancer 9.6 CDH1 CD44
30 gastrointestinal stromal tumor 9.6 CDH1 CD44
31 myeloma, multiple 9.6 CDH1 CD44
32 nasopharyngeal carcinoma 9.6 CDH1 CD44
33 eye disease 9.6 CDH1 CD44
34 pancreatic adenocarcinoma 9.5 CDH1 CD44
35 squamous cell carcinoma, head and neck 9.4 CDH1 CD44
36 glioblastoma multiforme 9.2 CDH1 CD44

Graphical network of the top 20 diseases related to Hereditary Gastric Cancer:



Diseases related to Hereditary Gastric Cancer

Symptoms & Phenotypes for Hereditary Gastric Cancer

Drugs & Therapeutics for Hereditary Gastric Cancer

Drugs for Hereditary Gastric Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
2 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study Evaluating Confocal Endoscopic Microscopy for Detection of Early Stage Gastric Cancer in Subjects With Hereditary Diffuse Gastric Cancer Syndrome Recruiting NCT03648879 Phase 2
2 Efficacy of Adding Trastuzumab to Standard Chemotherapy in Patients With Advanced HER2-negative Gastric Cancer and HER2 Positive Expression in Circulating Tumor Cells Not yet recruiting NCT04168931 Phase 2 Trastuzumab
3 Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer Recruiting NCT03030404

Search NIH Clinical Center for Hereditary Gastric Cancer

Genetic Tests for Hereditary Gastric Cancer

Anatomical Context for Hereditary Gastric Cancer

MalaCards organs/tissues related to Hereditary Gastric Cancer:

40
Breast, Ovary, Tongue, Prostate, Testes, Eye

Publications for Hereditary Gastric Cancer

Articles related to Hereditary Gastric Cancer:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing. 61
31949278 2020
2
Feasibility of Identifying Patients at High Risk of Hereditary Gastric Cancer Based on Clinicopathological Variables. 61
31519615 2019
3
Risk Assessment and Genetic Testing for Inherited Gastrointestinal Syndromes. 61
31787853 2019
4
Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions. 61
31435167 2019
5
Hereditary gastric cancer: what's new? Update 2013-2018. 61
30989426 2019
6
Contemporary paradigm for the evaluation and treatment of hereditary gastric cancer. 61
30976717 2019
7
Familial aggregation of gastric cancer with microsatellite instability. 61
30071769 2018
8
Hereditary diffuse gastric cancer: how to look for and how to manage it. 61
29869323 2018
9
Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders. 61
29103540 2017
10
[Current status of hereditary gastrointestinal neoplasms]. 61
29178089 2017
11
[Hereditary gastric and pancreatic cancer]. 61
28484856 2017
12
Gastrointestinal tract cancers: Genetics, heritability and germ line mutations. 61
28454282 2017
13
Diagnosis and Management of Hereditary Gastric Cancer. 61
27075348 2016
14
Familial Gastric Cancers. 61
26424758 2015
15
Prevalence of deleterious ATM germline mutations in gastric cancer patients. 61
26506520 2015
16
Hereditary Gastric Cancer Syndromes. 61
26363540 2015
17
When Is Endoscopic Follow-up Appropriate After Helicobacter pylori Eradication Therapy? 61
26314670 2015
18
Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer. 61
25576241 2015
19
Hereditary Gastric Cancer: An Update at 15 Years. 61
26182297 2015
20
[Current status of the study on hereditary diffuse gastric cancer]. 61
25809335 2015
21
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. 61
25645574 2015
22
[E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer]. 61
25613626 2015
23
The normal neuroendocrine cells of the upper gastrointestinal tract lack E-cadherin. 61
24742175 2014
24
[E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer]. 61
23353171 2013
25
Cancer in Māori: lessons from prostate, colorectal and gastric cancer and progress in hereditary stomach cancer in New Zealand. 61
23279256 2013
26
Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer. 61
24204729 2013
27
Hereditary gastric cancer. 61
23052347 2012
28
Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. 61
22388873 2012
29
Germline promoter hypermethylation of tumor suppressor genes in gastric cancer. 61
22228973 2012
30
The first evidence of hereditary and familial gastric cancer in Latvia: implications for prevention. 61
22885366 2012
31
Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention. 61
21865131 2011
32
[Familial gastric cancer: diagnosis, treatment and periodic surveillance]. 61
21329544 2011
33
[Hereditary gastric cancer: the pathologist's point of view]. 61
21055555 2010
34
De novo expression of CD44 variants in sporadic and hereditary gastric cancer. 61
20856229 2010
35
[Hereditary gastric cancer]. 61
20824432 2010
36
[Associations of E-cadherin gene (CDH1) and hereditary gastric cancer in China]. 61
19781162 2009
37
[Hereditary non-polyposis colorectal cancer associated with hereditary gastric cancer. A case report.]. 61
19858019 2009
38
Hereditary gastric cancer. 61
19414142 2009
39
Preemptive total gastrectomy for hereditary gastric cancer. 61
17458604 2007
40
Napoleon Bonaparte's gastric cancer: a clinicopathologic approach to staging, pathogenesis, and etiology. 61
17203089 2007
41
Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer. 61
16555931 2006
42
Geno- and pheno-typic characterization in ten patients with double-primary gastric and colorectal adenocarcinomas. 61
15083323 2004
43
Genetic screening for familial gastric cancer. 61
20233471 2004
44
Nuclear pedigree criteria for the identification of individuals suspected to be at risk of an inherited predisposition to gastric cancer. 61
20233472 2004
45
Clinicopathologic characteristics of gastric cancer in a young patient population. 61
15019915 2004
46
Familial gastric cancer. 61
14762482 2003
47
[Hereditary gastric cancer. Genetics and clinical management]. 61
12940100 2003
48
Genetic epidemiologic aspects of gastric cancer in Iceland. 61
12168964 2002
49
Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer. 61
11948460 2002
50
E-cadherin mutations and hereditary gastric cancer: prevention by resection? 61
12145417 2002

Variations for Hereditary Gastric Cancer

Expression for Hereditary Gastric Cancer

Search GEO for disease gene expression data for Hereditary Gastric Cancer.

Pathways for Hereditary Gastric Cancer

Pathways related to Hereditary Gastric Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.81 CDH1 CD44
2
Show member pathways
11.15 CDH1 CD44
3 10.71 CDH1 CD44

GO Terms for Hereditary Gastric Cancer

Cellular components related to Hereditary Gastric Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.62 CDH1 CD44

Biological processes related to Hereditary Gastric Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.16 CDH1 CD44
2 extracellular matrix organization GO:0030198 8.96 CDH1 CD44
3 cell-cell adhesion GO:0098609 8.62 CDH1 CD44

Sources for Hereditary Gastric Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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