MCID: HRD215
MIFTS: 21

Hereditary Gastric Cancer

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Hereditary Gastric Cancer

MalaCards integrated aliases for Hereditary Gastric Cancer:

Name: Hereditary Gastric Cancer 58
Hereditary Cancer of Stomach 58

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Orphanet 58 ORPHA423776

Summaries for Hereditary Gastric Cancer

MalaCards based summary : Hereditary Gastric Cancer, also known as hereditary cancer of stomach, is related to gastric cancer, hereditary diffuse and gastric cancer. An important gene associated with Hereditary Gastric Cancer is CD44 (CD44 Molecule (Indian Blood Group)), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. Affiliated tissues include prostate.

Related Diseases for Hereditary Gastric Cancer

Diseases in the Gastric Cancer family:

Hereditary Gastric Cancer

Diseases related to Hereditary Gastric Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 gastric cancer, hereditary diffuse 11.2
2 gastric cancer 10.5
3 diffuse gastric cancer 10.4
4 gastric adenocarcinoma 10.2
5 gastric adenocarcinoma and proximal polyposis of the stomach 10.1
6 signet ring cell adenocarcinoma 10.0
7 microinvasive gastric cancer 9.9
8 adenocarcinoma 9.9
9 lynch syndrome 9.9
10 linitis plastica 9.9
11 hereditary nonpolyposis colon cancer 9.9
12 pre-malignant neoplasm 9.8 CDH1 CD44
13 follicular adenoma 9.8 CDH1 CD44
14 ductal carcinoma in situ 9.8 CDH1 CD44
15 malignant ovarian surface epithelial-stromal neoplasm 9.8 CDH1 CD44
16 ovary epithelial cancer 9.8 CDH1 CD44
17 colorectal adenocarcinoma 9.8 CDH1 CD44
18 laryngeal squamous cell carcinoma 9.8 CDH1 CD44
19 squamous cell carcinoma 9.8 CDH1 CD44
20 breast ductal carcinoma 9.8 CDH1 CD44
21 transitional cell carcinoma 9.8 CDH1 CD44
22 hepatoblastoma 9.8 CDH1 CD44
23 pancreatic ductal adenocarcinoma 9.8 CDH1 CD44
24 gastrointestinal stromal tumor 9.8 CDH1 CD44
25 basal cell carcinoma 9.7 CDH1 CD44
26 squamous cell carcinoma, head and neck 9.7 CDH1 CD44
27 eye disease 9.7 CDH1 CD44
28 pheochromocytoma 9.7 CDH1 CD44
29 skin carcinoma 9.7 CDH1 CD44
30 leukemia, acute myeloid 9.6 CDH1 CD44
31 medulloblastoma 9.6 CDH1 CD44
32 renal cell carcinoma, nonpapillary 9.5 CDH1 CD44

Graphical network of the top 20 diseases related to Hereditary Gastric Cancer:



Diseases related to Hereditary Gastric Cancer

Symptoms & Phenotypes for Hereditary Gastric Cancer

Drugs & Therapeutics for Hereditary Gastric Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer Recruiting NCT03030404

Search NIH Clinical Center for Hereditary Gastric Cancer

Genetic Tests for Hereditary Gastric Cancer

Anatomical Context for Hereditary Gastric Cancer

MalaCards organs/tissues related to Hereditary Gastric Cancer:

40
Prostate

Publications for Hereditary Gastric Cancer

Articles related to Hereditary Gastric Cancer:

(show top 50) (show all 63)
# Title Authors PMID Year
1
Recent advances in the pathology of heritable gastric cancer syndromes. 61
33382491 2021
2
Two independent families with strongly suspected hereditary diffuse gastric cancer based on the probands' endoscopic findings. 61
32594425 2020
3
Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes. 61
33179620 2020
4
Characteristics of cancer susceptibility genes mutations in 282 patients with gastric adenocarcinoma. 61
32963463 2020
5
Family's History Based on the CDH1 Germline Variant (c.360delG) and a Suspected Hereditary Gastric Cancer Form. 61
32664545 2020
6
Gastric adenocarcinoma and proximal polyposis of the stomach – a rare form of hereditary gastric cancer. 61
32378851 2020
7
[Hereditary gastric cancer: Challenges for the pathologist in 2020]. 61
32147190 2020
8
Hereditary gastric cancer: Three rules to reduce missed diagnoses. 61
32308342 2020
9
Clinical relevance of somatic mutations in main driver genes detected in gastric cancer patients by next-generation DNA sequencing. 61
31949278 2020
10
Risk Assessment and Genetic Testing for Inherited Gastrointestinal Syndromes. 61
31787853 2019
11
Feasibility of Identifying Patients at High Risk of Hereditary Gastric Cancer Based on Clinicopathological Variables. 61
31519615 2019
12
Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions. 61
31435167 2019
13
Hereditary gastric cancer: what's new? Update 2013-2018. 61
30989426 2019
14
Contemporary paradigm for the evaluation and treatment of hereditary gastric cancer. 61
30976717 2019
15
Familial aggregation of gastric cancer with microsatellite instability. 61
30071769 2018
16
Hereditary diffuse gastric cancer: how to look for and how to manage it. 61
29869323 2018
17
Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders. 61
29103540 2017
18
[Current status of hereditary gastrointestinal neoplasms]. 61
29178089 2017
19
[Hereditary gastric and pancreatic cancer]. 61
28484856 2017
20
Gastrointestinal tract cancers: Genetics, heritability and germ line mutations. 61
28454282 2017
21
Diagnosis and Management of Hereditary Gastric Cancer. 61
27075348 2016
22
Familial Gastric Cancers. 61
26424758 2015
23
Prevalence of deleterious ATM germline mutations in gastric cancer patients. 61
26506520 2015
24
Hereditary Gastric Cancer Syndromes. 61
26363540 2015
25
When Is Endoscopic Follow-up Appropriate After Helicobacter pylori Eradication Therapy? 61
26314670 2015
26
Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer. 61
25576241 2015
27
Hereditary Gastric Cancer: An Update at 15 Years. 61
26182297 2015
28
[Current status of the study on hereditary diffuse gastric cancer]. 61
25809335 2015
29
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. 61
25645574 2015
30
[E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer]. 61
25613626 2015
31
The normal neuroendocrine cells of the upper gastrointestinal tract lack E-cadherin. 61
24742175 2014
32
[E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer]. 61
23353171 2013
33
Cancer in Māori: lessons from prostate, colorectal and gastric cancer and progress in hereditary stomach cancer in New Zealand. 61
23279256 2013
34
Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer. 61
24204729 2013
35
Hereditary gastric cancer. 61
23052347 2012
36
Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. 61
22388873 2012
37
Germline promoter hypermethylation of tumor suppressor genes in gastric cancer. 61
22228973 2012
38
The first evidence of hereditary and familial gastric cancer in Latvia: implications for prevention. 61
22885366 2012
39
Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention. 61
21865131 2011
40
[Familial gastric cancer: diagnosis, treatment and periodic surveillance]. 61
21329544 2011
41
De novo expression of CD44 variants in sporadic and hereditary gastric cancer. 61
20856229 2010
42
[Hereditary gastric cancer: the pathologist's point of view]. 61
21055555 2010
43
[Hereditary gastric cancer]. 61
20824432 2010
44
[Associations of E-cadherin gene (CDH1) and hereditary gastric cancer in China]. 61
19781162 2009
45
Hereditary gastric cancer. 61
19414142 2009
46
[Hereditary non-polyposis colorectal cancer associated with hereditary gastric cancer. A case report.]. 61
19858019 2009
47
Preemptive total gastrectomy for hereditary gastric cancer. 61
17458604 2007
48
Napoleon Bonaparte's gastric cancer: a clinicopathologic approach to staging, pathogenesis, and etiology. 61
17203089 2007
49
Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer. 61
16555931 2006
50
Geno- and pheno-typic characterization in ten patients with double-primary gastric and colorectal adenocarcinomas. 61
15083323 2004

Variations for Hereditary Gastric Cancer

Expression for Hereditary Gastric Cancer

Search GEO for disease gene expression data for Hereditary Gastric Cancer.

Pathways for Hereditary Gastric Cancer

Pathways related to Hereditary Gastric Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.81 CDH1 CD44
2
Show member pathways
11.15 CDH1 CD44
3 10.71 CDH1 CD44

GO Terms for Hereditary Gastric Cancer

Biological processes related to Hereditary Gastric Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.16 CDH1 CD44
2 extracellular matrix organization GO:0030198 8.96 CDH1 CD44
3 cell-cell adhesion GO:0098609 8.62 CDH1 CD44

Sources for Hereditary Gastric Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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