MCID: HRD215
MIFTS: 23

Hereditary Gastric Cancer

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Hereditary Gastric Cancer

MalaCards integrated aliases for Hereditary Gastric Cancer:

Name: Hereditary Gastric Cancer 59
Hereditary Cancer of Stomach 59

Classifications:



External Ids:

Orphanet 59 ORPHA423776

Summaries for Hereditary Gastric Cancer

MalaCards based summary : Hereditary Gastric Cancer, also known as hereditary cancer of stomach, is related to gastric adenocarcinoma and gastric cancer, hereditary diffuse. An important gene associated with Hereditary Gastric Cancer is CD44 (CD44 Molecule (Indian Blood Group)), and among its related pathways/superpathways are Degradation of the extracellular matrix and ECM-receptor interaction. Affiliated tissues include prostate, testes and breast.

Related Diseases for Hereditary Gastric Cancer

Graphical network of the top 20 diseases related to Hereditary Gastric Cancer:



Diseases related to Hereditary Gastric Cancer

Symptoms & Phenotypes for Hereditary Gastric Cancer

Drugs & Therapeutics for Hereditary Gastric Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study Evaluating Confocal Endoscopic Microscopy for Detection of Early Stage Gastric Cancer in Subjects With Hereditary Diffuse Gastric Cancer Syndrome Recruiting NCT03648879 Phase 2
2 Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer Recruiting NCT03030404

Search NIH Clinical Center for Hereditary Gastric Cancer

Genetic Tests for Hereditary Gastric Cancer

Anatomical Context for Hereditary Gastric Cancer

MalaCards organs/tissues related to Hereditary Gastric Cancer:

41
Prostate, Testes, Breast

Publications for Hereditary Gastric Cancer

Articles related to Hereditary Gastric Cancer:

(show top 50) (show all 52)
# Title Authors PMID Year
1
Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions. 38
31435167 2019
2
Hereditary gastric cancer: what's new? Update 2013-2018. 38
30989426 2019
3
Contemporary paradigm for the evaluation and treatment of hereditary gastric cancer. 38
30976717 2019
4
Familial aggregation of gastric cancer with microsatellite instability. 38
30071769 2018
5
Hereditary diffuse gastric cancer: how to look for and how to manage it. 38
29869323 2018
6
Emerging Concepts in Gastric Neoplasia: Heritable Gastric Cancers and Polyposis Disorders. 38
29103540 2017
7
[Current status of hereditary gastrointestinal neoplasms]. 38
29178089 2017
8
[Hereditary gastric and pancreatic cancer]. 38
28484856 2017
9
Gastrointestinal tract cancers: Genetics, heritability and germ line mutations. 38
28454282 2017
10
Diagnosis and Management of Hereditary Gastric Cancer. 38
27075348 2016
11
Familial Gastric Cancers. 38
26424758 2015
12
Prevalence of deleterious ATM germline mutations in gastric cancer patients. 38
26506520 2015
13
Hereditary Gastric Cancer Syndromes. 38
26363540 2015
14
When Is Endoscopic Follow-up Appropriate After Helicobacter pylori Eradication Therapy? 38
26314670 2015
15
Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer. 38
25576241 2015
16
Hereditary Gastric Cancer: An Update at 15 Years. 38
26182297 2015
17
[Current status of the study on hereditary diffuse gastric cancer]. 38
25809335 2015
18
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. 38
25645574 2015
19
[E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer]. 38
25613626 2015
20
The normal neuroendocrine cells of the upper gastrointestinal tract lack E-cadherin. 38
24742175 2014
21
Cancer in Māori: lessons from prostate, colorectal and gastric cancer and progress in hereditary stomach cancer in New Zealand. 38
23279256 2013
22
[E-cadherin expression and CDH1 promoter methylation in sporadic and hereditary gastric cancer]. 38
23353171 2013
23
Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer. 38
24204729 2013
24
Hereditary gastric cancer. 38
23052347 2012
25
Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. 38
22388873 2012
26
Germline promoter hypermethylation of tumor suppressor genes in gastric cancer. 38
22228973 2012
27
The first evidence of hereditary and familial gastric cancer in Latvia: implications for prevention. 38
22885366 2012
28
Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention. 38
21865131 2011
29
[Familial gastric cancer: diagnosis, treatment and periodic surveillance]. 38
21329544 2011
30
[Hereditary gastric cancer: the pathologist's point of view]. 38
21055555 2010
31
De novo expression of CD44 variants in sporadic and hereditary gastric cancer. 38
20856229 2010
32
[Hereditary gastric cancer]. 38
20824432 2010
33
[Associations of E-cadherin gene (CDH1) and hereditary gastric cancer in China]. 38
19781162 2009
34
Hereditary gastric cancer. 38
19414142 2009
35
[Hereditary non-polyposis colorectal cancer associated with hereditary gastric cancer. A case report.]. 38
19858019 2009
36
Preemptive total gastrectomy for hereditary gastric cancer. 38
17458604 2007
37
Napoleon Bonaparte's gastric cancer: a clinicopathologic approach to staging, pathogenesis, and etiology. 38
17203089 2007
38
Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer. 38
16555931 2006
39
Geno- and pheno-typic characterization in ten patients with double-primary gastric and colorectal adenocarcinomas. 38
15083323 2004
40
Genetic screening for familial gastric cancer. 38
20233471 2004
41
Nuclear pedigree criteria for the identification of individuals suspected to be at risk of an inherited predisposition to gastric cancer. 38
20233472 2004
42
Clinicopathologic characteristics of gastric cancer in a young patient population. 38
15019915 2004
43
Familial gastric cancer. 38
14762482 2003
44
[Hereditary gastric cancer. Genetics and clinical management]. 38
12940100 2003
45
Genetic epidemiologic aspects of gastric cancer in Iceland. 38
12168964 2002
46
Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer. 38
11948460 2002
47
E-cadherin mutations and hereditary gastric cancer: prevention by resection? 38
12145417 2002
48
E-cadherin is not frequently mutated in hereditary gastric cancer. 38
11332401 2001
49
hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer. 38
12132870 2001
50
Report on the first meeting of the International Collaborative Group on Hereditary Gastric Cancer. 38
11058622 2000

Variations for Hereditary Gastric Cancer

Expression for Hereditary Gastric Cancer

Search GEO for disease gene expression data for Hereditary Gastric Cancer.

Pathways for Hereditary Gastric Cancer

Pathways related to Hereditary Gastric Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.81 CDH1 CD44
2
Show member pathways
11.15 CDH1 CD44
3 10.71 CDH1 CD44

GO Terms for Hereditary Gastric Cancer

Cellular components related to Hereditary Gastric Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.62 CDH1 CD44

Biological processes related to Hereditary Gastric Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.16 CDH1 CD44
2 extracellular matrix organization GO:0030198 8.96 CDH1 CD44
3 cell-cell adhesion GO:0098609 8.62 CDH1 CD44

Sources for Hereditary Gastric Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....