MCID: HRM002
MIFTS: 39

Hermaphroditism

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Hermaphroditism

Summaries for Hermaphroditism

MalaCards based summary : Hermaphroditism is related to 46,xx sex reversal 1 and pseudohermaphroditism. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways/superpathways are Signaling by Wnt and Deactivation of the beta-catenin transactivating complex. The drugs Dehydroepiandrosterone and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include testes, testis and uterus, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 76 In biology, a hermaphrodite (/hɜːrˈmæfrədaɪt/) is an organism that has complete or partial reproductive... more...

Related Diseases for Hermaphroditism

Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 46,xx sex reversal 1 33.5 SOX9 SRY
2 pseudohermaphroditism 32.5 SRD5A2 SRY
3 gonadoblastoma 30.6 SOX9 SRY
4 mixed gonadal dysgenesis 30.5 SOX9 SRY
5 gonadal dysgenesis 30.4 SOX9 SRY
6 46 xy gonadal dysgenesis 30.2 SHBG SOX9 SRY
7 campomelic dysplasia 30.0 SOX9 SRY
8 hypospadias 29.9 SOX9 SRD5A2 SRY
9 sex differentiation disease 29.7 SHBG SRY
10 alopecia, androgenetic, 1 29.7 SHBG SRD5A2
11 gynecomastia 29.6 SHBG SRY
12 androgen insensitivity syndrome 29.2 SHBG SRD5A2 SRY
13 amenorrhea 29.0 SHBG SRY WNT4
14 palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal 11.5
15 46,xy sex reversal 1 11.4
16 leech infestation 10.9
17 denys-drash syndrome 10.9
18 46,xy partial gonadal dysgenesis 10.5 SOX9 SRY
19 testicular disease 10.4 SOX9 SRY
20 persistent mullerian duct syndrome 10.3 SOX9 SRY
21 frasier syndrome 10.3 SOX9 SRY
22 complete androgen insensitivity syndrome 10.1 SHBG SRY
23 gonadal disease 10.0 SHBG SRY
24 inguinal hernia 10.0
25 seminoma 9.9
26 gonadal dysgenesis, xy type, with associated anomalies 9.9
27 reproductive system disease 9.9 SHBG SRY
28 hyperandrogenism 9.8 SHBG WNT4
29 hypogonadotropic hypogonadism 9.8
30 vaginitis 9.8
31 freemartinism 9.8
32 turner syndrome 9.8 SHBG SRY
33 cryptorchidism, unilateral or bilateral 9.7 SHBG SRY
34 hydatidiform mole, recurrent, 1 9.7
35 gonadal agenesis 9.7
36 myelodysplastic syndrome 9.7
37 alopecia 9.7
38 hepatitis 9.7
39 male infertility 9.7
40 androgenic alopecia 9.7
41 ectopic pregnancy 9.7
42 microphthalmia 9.7
43 sarcoma 9.7
44 urethritis 9.7
45 squamous cell carcinoma 9.7
46 sertoli cell tumor 9.7
47 gestational trophoblastic neoplasm 9.7
48 choriocarcinoma 9.7
49 adrenal carcinoma 9.7
50 trophoblastic neoplasm 9.7

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to Hermaphroditism

Symptoms & Phenotypes for Hermaphroditism

MGI Mouse Phenotypes related to Hermaphroditism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.35 FIGLA RSPO1 SOX9 SRD5A2 WNT4
2 reproductive system MP:0005389 9.02 FIGLA RSPO1 SOX9 SRD5A2 WNT4

Drugs & Therapeutics for Hermaphroditism

Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 1, Phase 2 53-43-0 9860744
2 Adjuvants, Immunologic Phase 1, Phase 2
3 DHEA (Dehydroepiandrosterone) Nutraceutical Phase 1, Phase 2
4
Epinephrine Approved, Vet_approved 51-43-4 5816
5
Racepinephrine Approved 329-65-7 838
6 Hops Approved, Nutraceutical Not Applicable
7 Epinephryl borate
8 Adrenergic Agents
9 Adrenergic Agonists
10 Adrenergic alpha-Agonists
11 Adrenergic beta-Agonists
12 Anti-Asthmatic Agents
13 Autonomic Agents
14 Bronchodilator Agents
15 Mydriatics
16 Neurotransmitter Agents
17 Peripheral Nervous System Agents
18 Psychotropic Drugs
19 Respiratory System Agents
20 Vasoconstrictor Agents
21 Analgesics
22 Analgesics, Non-Narcotic
23 Anti-Inflammatory Agents
24 Anti-Inflammatory Agents, Non-Steroidal
25 Antirheumatic Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer Recruiting NCT02474641 Phase 3
2 Chinese Medicine(Hu Yang Yang Kun Formula) for Primary Ovarian Insufficiency Completed NCT02794948 Phase 1, Phase 2
3 Decision Support for Parents Receiving Information About Child's Rare Disease Completed NCT01875640
4 Qualitative Research on Women With Congenital Adrenal Hyperplasia Completed NCT00559078
5 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
6 National Survey on Asthma Completed NCT00770250
7 Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities) Recruiting NCT02986126 Not Applicable
8 Generating Evidence for a Support Package to Stabilize Youth Trajectories Out of Homelessness Recruiting NCT03277794 Not Applicable
9 Follow-up of a National Cohort of Melanoma Stage IV and Unresectable Stage III Patients Recruiting NCT02828202
10 Reducing LGBTQ Adolescent Suicide Active, not recruiting NCT02875535 Not Applicable
11 Gene Polymorphisms Influencing Steroid Synthesis and Action Withdrawn NCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

Anatomical Context for Hermaphroditism

MalaCards organs/tissues related to Hermaphroditism:

41
Testes, Testis, Uterus, Kidney, Ovary, Pituitary, Liver

Publications for Hermaphroditism

Articles related to Hermaphroditism:

(show top 50) (show all 471)
# Title Authors Year
1
Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish <i>Synbranchus marmoratus</i> (Synbranchiformes: Synbranchidae). ( 29695033 )
2018
2
Surgical correction of urethral diverticulum in a female pseudo-hermaphrodite crossbred calf. ( 29805465 )
2018
3
CRISPR/Cas9-Mediated Mosaic Mutation of<i>SRY</i>Gene Induces Hermaphroditism in Rabbits. ( 29439141 )
2018
4
Draft Genome Sequence of Salmacisia buchloA<ana (Basidiomycota), Which Induces Hermaphroditism in Dioecious Buffalograss. ( 28385853 )
2017
5
Histological profiling of gonads depicting protandrous hermaphroditism in Eleutheronema tetradactylum. ( 28474376 )
2017
6
Phase-specific expression of an insulin-like androgenic gland factor in a marine shrimp Lysmata wurdemanni: Implication for maintaining protandric simultaneous hermaphroditism. ( 28235100 )
2017
7
Hermaphroditism: an obsolete diagnosis? ( 28500834 )
2017
8
Hermaphroditism in the dash-and-dot goatfish Parupeneus barberinus. ( 28097655 )
2017
9
Hermaphroditism in the white spot grouper Epinephelus coeruleopunctatus (Pisces: Serranidae) harvested from Padang City waters, Indonesia. ( 28491284 )
2017
10
Persistence of Reduced Androgenic Glands after Protandric Sex Change Suggests a Basis for Simultaneous Hermaphroditism in a Caridean Shrimp. ( 27132133 )
2016
11
Hermaphroditism in a Roman fresco from Herculaneum (first century A.D.), National Archaeological Museum, Naples, Italy. ( 27412518 )
2016
12
&amp;quot;The persistence of memory&amp;quot;-Hermaphroditism in nematodes. ( 27291983 )
2016
13
Gonad development and hermaphroditism in the ascidian Botryllus schlosseri. ( 27228546 )
2016
14
Hermaphroditism in Leonardo da Vinci's Drawing &amp;quot;Angel in the Flesh&amp;quot; (1513-1515). ( 26980592 )
2016
15
Rediscovering hermaphroditism in Grammatidae with the description of the testicular gland in Brazilian Basslet Gramma brasiliensis. ( 27097082 )
2016
16
Expression of steroid hormone receptors in the genital structures of a true hermaphrodite pug dog. ( 25472589 )
2015
17
The Basement Membrane and the Sex Establishment in the Juvenile Hermaphroditism During Gonadal Differentiation of the Gymnocorymbus ternetzi (Teleostei: Characiformes: Characidae). ( 26386207 )
2015
18
Selfish male-determining element favors the transition from hermaphroditism to androdioecy. ( 25643740 )
2015
19
A case of true hermaphroditism presenting as a testicular tumour. ( 25774314 )
2015
20
Direct reciprocity stabilizes simultaneous hermaphroditism at high mating rates: A model of sex allocation with egg trading. ( 26150086 )
2015
21
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. ( 24742721 )
2014
22
Embryology and adult urology - Not always mutually exclusive: A case report on true hermaphroditism at an adult urology clinic. ( 25295140 )
2014
23
Evidence of Hermaphroditism and Sex Ratio Distortion in the Fungal Feeding Nematode Bursaphelenchus okinawaensis. ( 25122669 )
2014
24
Cooperation promotes the evolution of separate sexes from hermaphrodites with unitary growth. ( 24126242 )
2014
25
7- OVOTESTICULAR DSD (TRUE HERMAPHRODITISM). ( 25105460 )
2014
26
A small XY chromosomal region explains sex determination in wild dioecious V. vinifera and the reversal to hermaphroditism in domesticated grapevines. ( 25179565 )
2014
27
Reproductive cycle and strategy of Anodonta anatina (L., 1758): notes on hermaphroditism. ( 23776103 )
2013
28
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. ( 23727055 )
2013
29
Histological and genetic characterization of true hermaphroditism in Korean pigs. ( 23018792 )
2013
30
Linking micromorphism, brooding, and hermaphroditism in brachiopods: insights from Caribbean Argyrotheca (Brachiopoda). ( 23400897 )
2013
31
Phylogenetic perspectives on the evolution of functional hermaphroditism in teleost fishes. ( 23817661 )
2013
32
The role of androdioecy and gynodioecy in mediating evolutionary transitions between dioecy and hermaphroditism in the animalia. ( 23206127 )
2012
33
True hermaphrodite presenting as primary amenorrhea. ( 22837933 )
2012
34
28S rDNA haplotypes of males are distinct from those of androgenetic hermaphrodites in the clam Corbicula leana. ( 22526872 )
2012
35
Sequential hermaphroditism and personality in a clonal vertebrate: the mangrove killifish. ( 22365923 )
2012
36
Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog. ( 23543931 )
2012
37
Iatrogenic androgenetic alopecia in a male phenotype 46XX true hermaphrodite. ( 21729028 )
2012
38
True hermaphroditism: first evidence of an ovotestis in a cetacean species. ( 20708743 )
2011
39
Back-and-forth hermaphroditism: phylogenetic context of reproductive system evolution in subdioecious Daphne laureola. ( 21644956 )
2011
40
A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. ( 20861501 )
2011
41
The evolution of hermaphroditism by an infectious male-derived cell lineage: an inclusive-fitness analysis. ( 21750383 )
2011
42
Analysis of expressed sequence tags from the liver and ovary of the euryhaline hermaphroditic fish, Kryptolebias marmoratus. ( 21612991 )
2011
43
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite. ( 22070612 )
2011
44
A fungal parasite regulates a putative female-suppressor gene homologous to maize tasselseed2 and causes induced hermaphroditism in male buffalograss. ( 20121446 )
2010
45
Evidence for hermaphroditism in the Squalius alburnoides allopolyploid fish complex. ( 20559019 )
2010
46
Hermaphroditism among dioecious Tagelus plebeius (Lightfoot, 1786) (Mollusca, Psammobiidae) and Iphigenia brasiliana (Lamarck, 1818) (Mollusca, Donacidae) on the Cachoeira River estuary, IlhAcus, Bahia, Brazil. ( 20231968 )
2010
47
Molecular mechanisms underlying sex change in hermaphroditic groupers. ( 20467860 )
2010
48
Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes. ( 20823339 )
2010
49
Surgical treatment of hermaphroditism: experience with 25 cases. ( 19806042 )
2009
50
Sry-negative XX true hermaphroditism in a roe deer. ( 18524504 )
2009

Variations for Hermaphroditism

Expression for Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for Hermaphroditism

Pathways related to Hermaphroditism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 RSPO1 SOX9 SRY WNT4
2 10.59 SOX9 SRY

GO Terms for Hermaphroditism

Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.77 FIGLA SOX9 SRD5A2 SRY WNT4
2 cell fate commitment GO:0045165 9.51 SOX9 WNT4
3 cellular response to transforming growth factor beta stimulus GO:0071560 9.49 SOX9 WNT4
4 branching involved in ureteric bud morphogenesis GO:0001658 9.48 SOX9 WNT4
5 epithelial to mesenchymal transition GO:0001837 9.46 SOX9 WNT4
6 oocyte development GO:0048599 9.43 FIGLA WNT4
7 male gonad development GO:0008584 9.43 SOX9 SRD5A2 WNT4
8 male sex determination GO:0030238 9.4 SOX9 SRY
9 androgen biosynthetic process GO:0006702 9.32 SRD5A2 WNT4
10 positive regulation of male gonad development GO:2000020 9.16 SOX9 SRY
11 renal vesicle induction GO:0072034 8.96 SOX9 WNT4
12 sex differentiation GO:0007548 8.8 SRD5A2 SRY WNT4

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 8.62 SOX9 SRY

Sources for Hermaphroditism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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