MCID: HRM002
MIFTS: 37

Hermaphroditism

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Hermaphroditism

Summaries for Hermaphroditism

MalaCards based summary : Hermaphroditism is related to 46,xx sex reversal 1 and 46,xy sex reversal 1. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways/superpathways are Metabolism of steroid hormones and Regulation of Androgen receptor activity. The drugs Dehydroepiandrosterone and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include testes, testis and uterus, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 76 In biology, a hermaphrodite (/h�?ːr�?mæfr�?daɪt/) is an organism that has complete or partial... more...

Related Diseases for Hermaphroditism

Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 46,xx sex reversal 1 33.0 SOX9 SRY
2 46,xy sex reversal 1 32.5 SOX9 SRY
3 pseudohermaphroditism 32.2 AR SRD5A2 SRY
4 46 xy gonadal dysgenesis 31.1 SOX9 SRY
5 gonadal dysgenesis 30.6 SOX9 SRY
6 mixed gonadal dysgenesis 30.4 SOX9 SRY
7 gonadoblastoma 30.3 SOX9 SRY
8 campomelic dysplasia 29.8 SOX9 SRY
9 amenorrhea 29.8 SRY WNT4
10 sex differentiation disease 29.8 AR SRY
11 alopecia, androgenetic, 1 29.8 AR SRD5A2
12 gynecomastia 29.8 AR CGA SRY
13 hypospadias 29.8 AR SOX9 SRD5A2 SRY
14 androgen insensitivity syndrome 29.3 AR CGA SRD5A2 SRY
15 palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal 11.7
16 leech infestation 11.1
17 denys-drash syndrome 11.1
18 46,xy partial gonadal dysgenesis 10.1 SOX9 SRY
19 seminoma 10.1
20 dysgerminoma 10.1
21 persistent mullerian duct syndrome 10.1 SOX9 SRY
22 anorchia 10.1 CGA SRY
23 frasier syndrome 10.1 SOX9 SRY
24 inguinal hernia 10.1
25 hypogonadotropic hypogonadism 10.1
26 47, xxy 10.1
27 gonadal dysgenesis, xy type, with associated anomalies 10.1
28 prostatic hyperplasia, benign 10.0 AR SRD5A2
29 gonadal disease 10.0 AR SRY
30 complete androgen insensitivity syndrome 9.9 AR CGA SRY
31 germ cell cancer 9.9 AR CGA
32 cryptorchidism, unilateral or bilateral 9.9 AR CGA SRY
33 pseudovaginal perineoscrotal hypospadias 9.9 AR CGA SRD5A2
34 testicular cancer 9.8 AR CGA
35 lipoid congenital adrenal hyperplasia 9.8
36 hydatidiform mole, recurrent, 1 9.8
37 gonadal agenesis 9.8
38 myelodysplastic syndrome 9.8
39 alopecia 9.8
40 male infertility 9.8
41 spinal muscular atrophy 9.8
42 androgenic alopecia 9.8
43 ectopic pregnancy 9.8
44 microphthalmia 9.8
45 sarcoma 9.8
46 infant gynecomastia 9.8
47 acute cystitis 9.8
48 squamous cell carcinoma 9.8
49 sertoli cell tumor 9.8
50 gestational trophoblastic neoplasm 9.8

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to Hermaphroditism

Symptoms & Phenotypes for Hermaphroditism

MGI Mouse Phenotypes related to Hermaphroditism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 AR CGA FIGLA SOX9 SRD5A2 WNT4
2 reproductive system MP:0005389 9.1 AR CGA FIGLA SOX9 SRD5A2 WNT4

Drugs & Therapeutics for Hermaphroditism

Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 1, Phase 2 53-43-0 5881
2 Adjuvants, Immunologic Phase 1, Phase 2
3 Immunologic Factors Phase 1, Phase 2
4 DHEA (Dehydroepiandrosterone) Phase 1, Phase 2
5
Racepinephrine Approved 329-65-7 838
6
Epinephrine Approved, Vet_approved 51-43-4 5816
7 Hops Approved Not Applicable
8 Epinephryl borate
9 Sympathomimetics
10 Mydriatics
11 Respiratory System Agents
12 Vasoconstrictor Agents
13 Neurotransmitter Agents
14 Adrenergic Agonists
15 Adrenergic beta-Agonists
16 Peripheral Nervous System Agents
17 Adrenergic alpha-Agonists
18 Psychotropic Drugs
19 Bronchodilator Agents
20 Autonomic Agents
21 Adrenergic Agents
22 Anti-Asthmatic Agents
23 Anti-Inflammatory Agents
24 Antirheumatic Agents
25 Anti-Inflammatory Agents, Non-Steroidal
26 Analgesics, Non-Narcotic
27 Analgesics

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer Recruiting NCT02474641 Phase 3
2 Chinese Medicine(Hu Yang Yang Kun Formula) for Primary Ovarian Insufficiency Completed NCT02794948 Phase 1, Phase 2
3 Decision Support for Parents Receiving Information About Child's Rare Disease Completed NCT01875640
4 Qualitative Research on Women With Congenital Adrenal Hyperplasia Completed NCT00559078
5 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
6 National Survey on Asthma Completed NCT00770250
7 Generating Evidence for a Support Package to Stabilize Youth Trajectories Out of Homelessness Recruiting NCT03277794 Not Applicable
8 Follow-up of a National Cohort of Melanoma Stage IV and Unresectable Stage III Patients Recruiting NCT02828202
9 Reducing LGBTQ Adolescent Suicide Active, not recruiting NCT02875535 Not Applicable
10 Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities) Active, not recruiting NCT02986126 Not Applicable
11 Gene Polymorphisms Influencing Steroid Synthesis and Action Withdrawn NCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

Anatomical Context for Hermaphroditism

MalaCards organs/tissues related to Hermaphroditism:

41
Testes, Testis, Uterus, Kidney, Skin, Prostate, Myeloid

Publications for Hermaphroditism

Articles related to Hermaphroditism:

(show top 50) (show all 447)
# Title Authors Year
1
Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish <i>Synbranchus marmoratus</i> (Synbranchiformes: Synbranchidae). ( 29695033 )
2018
2
CRISPR/Cas9-Mediated Mosaic Mutation of<i>SRY</i>Gene Induces Hermaphroditism in Rabbits. ( 29439141 )
2018
3
Abnormal hermaphroditism in Pellona flavipinnis (Clupeiformes: Pristigasteridae). ( 30267411 )
2018
4
Intersex, Hermaphroditism, and Gonadal Plasticity in Vertebrates: Evolution of the Müllerian Duct and Amh/Amhr2 Signaling. ( 30303691 )
2018
5
Female Pseudo Hermaphroditism: Late Onset Congenital Adrenal Hyperplasia. ( 30465385 )
2018
6
Draft Genome Sequence of Salmacisia buchloA<ana (Basidiomycota), Which Induces Hermaphroditism in Dioecious Buffalograss. ( 28385853 )
2017
7
Histological profiling of gonads depicting protandrous hermaphroditism in Eleutheronema tetradactylum. ( 28474376 )
2017
8
Phase-specific expression of an insulin-like androgenic gland factor in a marine shrimp Lysmata wurdemanni: Implication for maintaining protandric simultaneous hermaphroditism. ( 28235100 )
2017
9
Hermaphroditism: an obsolete diagnosis? ( 28500834 )
2017
10
Hermaphroditism in the dash-and-dot goatfish Parupeneus barberinus. ( 28097655 )
2017
11
Hermaphroditism in the white spot grouper Epinephelus coeruleopunctatus (Pisces: Serranidae) harvested from Padang City waters, Indonesia. ( 28491284 )
2017
12
Persistence of Reduced Androgenic Glands after Protandric Sex Change Suggests a Basis for Simultaneous Hermaphroditism in a Caridean Shrimp. ( 27132133 )
2016
13
Hermaphroditism in a Roman fresco from Herculaneum (first century A.D.), National Archaeological Museum, Naples, Italy. ( 27412518 )
2016
14
&amp;quot;The persistence of memory&amp;quot;-Hermaphroditism in nematodes. ( 27291983 )
2016
15
Gonad development and hermaphroditism in the ascidian Botryllus schlosseri. ( 27228546 )
2016
16
Hermaphroditism in Leonardo da Vinci's Drawing &amp;quot;Angel in the Flesh&amp;quot; (1513-1515). ( 26980592 )
2016
17
Rediscovering hermaphroditism in Grammatidae with the description of the testicular gland in Brazilian Basslet Gramma brasiliensis. ( 27097082 )
2016
18
The Basement Membrane and the Sex Establishment in the Juvenile Hermaphroditism During Gonadal Differentiation of the Gymnocorymbus ternetzi (Teleostei: Characiformes: Characidae). ( 26386207 )
2015
19
Selfish male-determining element favors the transition from hermaphroditism to androdioecy. ( 25643740 )
2015
20
A case of true hermaphroditism presenting as a testicular tumour. ( 25774314 )
2015
21
Direct reciprocity stabilizes simultaneous hermaphroditism at high mating rates: A model of sex allocation with egg trading. ( 26150086 )
2015
22
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. ( 24742721 )
2014
23
Embryology and adult urology - Not always mutually exclusive: A case report on true hermaphroditism at an adult urology clinic. ( 25295140 )
2014
24
Evidence of Hermaphroditism and Sex Ratio Distortion in the Fungal Feeding Nematode Bursaphelenchus okinawaensis. ( 25122669 )
2014
25
7- OVOTESTICULAR DSD (TRUE HERMAPHRODITISM). ( 25105460 )
2014
26
A small XY chromosomal region explains sex determination in wild dioecious V. vinifera and the reversal to hermaphroditism in domesticated grapevines. ( 25179565 )
2014
27
Reproductive cycle and strategy of Anodonta anatina (L., 1758): notes on hermaphroditism. ( 23776103 )
2013
28
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. ( 23727055 )
2013
29
Histological and genetic characterization of true hermaphroditism in Korean pigs. ( 23018792 )
2013
30
Linking micromorphism, brooding, and hermaphroditism in brachiopods: insights from Caribbean Argyrotheca (Brachiopoda). ( 23400897 )
2013
31
Phylogenetic perspectives on the evolution of functional hermaphroditism in teleost fishes. ( 23817661 )
2013
32
The role of androdioecy and gynodioecy in mediating evolutionary transitions between dioecy and hermaphroditism in the animalia. ( 23206127 )
2012
33
Sequential hermaphroditism and personality in a clonal vertebrate: the mangrove killifish. ( 22365923 )
2012
34
Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog. ( 23543931 )
2012
35
True hermaphroditism: first evidence of an ovotestis in a cetacean species. ( 20708743 )
2011
36
Back-and-forth hermaphroditism: phylogenetic context of reproductive system evolution in subdioecious Daphne laureola. ( 21644956 )
2011
37
A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. ( 20861501 )
2011
38
The evolution of hermaphroditism by an infectious male-derived cell lineage: an inclusive-fitness analysis. ( 21750383 )
2011
39
A fungal parasite regulates a putative female-suppressor gene homologous to maize tasselseed2 and causes induced hermaphroditism in male buffalograss. ( 20121446 )
2010
40
Evidence for hermaphroditism in the Squalius alburnoides allopolyploid fish complex. ( 20559019 )
2010
41
Hermaphroditism among dioecious Tagelus plebeius (Lightfoot, 1786) (Mollusca, Psammobiidae) and Iphigenia brasiliana (Lamarck, 1818) (Mollusca, Donacidae) on the Cachoeira River estuary, IlhAcus, Bahia, Brazil. ( 20231968 )
2010
42
Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes. ( 20823339 )
2010
43
Surgical treatment of hermaphroditism: experience with 25 cases. ( 19806042 )
2009
44
Sry-negative XX true hermaphroditism in a roe deer. ( 18524504 )
2009
45
Diagnosis of true hermaphroditism in a fetus with acampomelic campomelic dysplasia. ( 19253311 )
2009
46
Ovotesticular disorder of sexual development (true hermaphroditism). ( 18822450 )
2009
47
Evolutionary perspectives on hermaphroditism in fishes. ( 19684459 )
2009
48
Accessory male investment can undermine the evolutionary stability of simultaneous hermaphroditism. ( 19605385 )
2009
49
Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidi. ( 19149894 )
2009
50
Pure ovarian choriocarinoma mimicking ectopic pregnancy in true hermaphroditism. ( 19363709 )
2009

Variations for Hermaphroditism

Expression for Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for Hermaphroditism

GO Terms for Hermaphroditism

Cellular components related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear transcription factor complex GO:0044798 8.62 SOX9 SRY

Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 AR CGA FIGLA SOX9 SRY
2 positive regulation of transcription, DNA-templated GO:0045893 9.8 AR SOX9 SRY WNT4
3 cell differentiation GO:0030154 9.77 FIGLA SOX9 SRD5A2 SRY WNT4
4 cell fate commitment GO:0045165 9.56 SOX9 WNT4
5 negative regulation of epithelial cell proliferation GO:0050680 9.55 AR SOX9
6 cellular response to transforming growth factor beta stimulus GO:0071560 9.54 SOX9 WNT4
7 branching involved in ureteric bud morphogenesis GO:0001658 9.52 SOX9 WNT4
8 epithelial to mesenchymal transition GO:0001837 9.51 SOX9 WNT4
9 prostate gland development GO:0030850 9.48 AR SOX9
10 male sex determination GO:0030238 9.43 SOX9 SRY
11 oocyte development GO:0048599 9.4 FIGLA WNT4
12 positive regulation of male gonad development GO:2000020 9.32 SOX9 SRY
13 renal vesicle induction GO:0072034 9.26 SOX9 WNT4
14 male gonad development GO:0008584 9.26 AR SOX9 SRD5A2 WNT4
15 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 AR WNT4
16 sex differentiation GO:0007548 8.92 AR SRD5A2 SRY WNT4

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.5 AR FIGLA SOX9
2 beta-catenin binding GO:0008013 9.26 AR SOX9
3 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.16 SOX9 SRY
4 transcription factor binding GO:0008134 9.13 AR FIGLA SRY
5 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 8.92 AR FIGLA SOX9 SRY

Sources for Hermaphroditism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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