MCID: HRM002
MIFTS: 35

Hermaphroditism

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Hermaphroditism

MalaCards integrated aliases for Hermaphroditism:

Name: Hermaphroditism 12 73 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3763
MeSH 44 D012734
NCIt 50 C45909
SNOMED-CT 67 52572004
ICD10 32 Q56.0
UMLS 70 C0019269

Summaries for Hermaphroditism

MalaCards based summary : Hermaphroditism is related to 46,xx sex reversal 1 and pseudohermaphroditism. An important gene associated with Hermaphroditism is RSPO1 (R-Spondin 1), and among its related pathways/superpathways are Regulation of Androgen receptor activity and Nongenotropic Androgen signaling. Affiliated tissues include ovary, testis and uterus, and related phenotypes are endocrine/exocrine gland and no phenotypic analysis

Wikipedia : 73 In reproductive biology, a hermaphrodite (/hɜːrˈmæfrədaɪt/) is an organism that has complete or partial... more...

Related Diseases for Hermaphroditism

Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 46,xx sex reversal 1 31.9 SRY SOX9 NR0B1
2 pseudohermaphroditism 31.0 WNT4 SRY SRD5A2 SOX9 NR0B1 AR
3 hypospadias 30.8 SRY SRD5A2 SOX9 AR
4 transsexualism 30.6 SRD5A2 AR
5 gynecomastia 30.5 SRY SRD5A2 SHBG CGA AR
6 inguinal hernia 30.4 AR AMHR2 AMH
7 amenorrhea 30.4 WNT4 SHBG FOXL2
8 hyperandrogenism 30.3 WNT4 SHBG AR
9 hypogonadotropic hypogonadism 30.2 SHBG NR0B1 AR AMH
10 turner syndrome 30.2 SRY SHBG NR0B1 AR AMH
11 mixed gonadal dysgenesis 30.1 SRY SOX9 FOXL2 AMHR2 AMH
12 penis agenesis 30.0 SRD5A2 CGA AR
13 gonadoblastoma 29.9 SRY SOX9 NR0B1 FOXL2 DMRT1 AMH
14 teratoma 29.7 DMRT1 CGA AMH
15 androgen insensitivity syndrome 29.6 SRY SRD5A2 SHBG NR0B1 CGA AR
16 male infertility 29.5 SRY SHBG DMRT1 AR
17 infertility 29.5 SHBG FOXL2 CGA AR AMH
18 46,xx sex reversal 29.4 WNT4 SRY SOX9 RSPO1 NR0B1 FOXL2
19 campomelic dysplasia 29.3 ZFY SRY SOX9 FOXL2 DMRT2 DMRT1
20 ovarian disease 29.3 SHBG FOXL2 CGA AR AMHR2 AMH
21 gonadal dysgenesis 29.2 ZFPM2 SRY SOX9 SHBG NR0B1 FOXL2
22 cryptorchidism, unilateral or bilateral 29.2 ZFPM2 SRD5A2 SOX9 SHBG NR0B1 DMRT1
23 disorder of sexual development 29.1 WNT4 SRD5A2 SOX9 SHBG NR0B1 FOXL2
24 46,xy sex reversal 28.0 ZFPM2 WNT4 SRY SRD5A2 SOX9 RSPO1
25 palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal 11.3
26 46,xy sex reversal 1 11.1
27 denys-drash syndrome 10.9
28 anorchia 10.3 SRY CGA
29 prostatic hyperplasia, benign 10.3 SRD5A2 AR
30 androgen insensitivity, partial 10.3 SHBG AR
31 47,xyy 10.3
32 postmenopausal atrophic vaginitis 10.3 SHBG AMH
33 prostatic hypertrophy 10.3 SRY SRD5A2 AR
34 alopecia, androgenetic, 1 10.3 SRD5A2 SHBG AR
35 alopecia 10.3 SRD5A2 SHBG AR
36 androgenic alopecia 10.3 SRD5A2 SHBG AR
37 ovarian serous adenofibroma 10.2 WNT4 AMH
38 infant gynecomastia 10.2
39 inhibited female orgasm 10.2 SHBG AMH
40 ovarian serous cystadenofibroma 10.2 WNT4 AMH
41 hair disease 10.2 SRD5A2 SHBG AR
42 luteoma 10.2 SHBG FOXL2 CGA
43 steroid inherited metabolic disorder 10.2 SHBG NR0B1 AMH
44 sebaceous gland disease 10.2 SHBG AR AMH
45 spermatogenic failure 8 10.2 DMRT1 AR
46 ovarian hyperstimulation syndrome 10.2 SHBG CGA AMH
47 oligospermia 10.2 SRD5A2 AR AMH
48 nonsyndromic disorders of testicular development 10.2 WNT4 SRY NR0B1 DMRT1
49 complete androgen insensitivity syndrome 10.2 SRY SHBG CGA AR
50 dysgerminoma 10.1

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to Hermaphroditism

Symptoms & Phenotypes for Hermaphroditism

MGI Mouse Phenotypes related to Hermaphroditism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.97 AMH AMHR2 AR CGA DMRT1 FOXL2
2 no phenotypic analysis MP:0003012 9.5 AMH AMHR2 FOXL2 SOX9 SRD5A2 WNT4
3 reproductive system MP:0005389 9.47 AMH AMHR2 AR CGA DMRT1 DMRT2

Drugs & Therapeutics for Hermaphroditism

Search Clinical Trials , NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

Anatomical Context for Hermaphroditism

MalaCards organs/tissues related to Hermaphroditism:

40
Ovary, Testis, Uterus, Testes, Pituitary, Colon, Kidney

Publications for Hermaphroditism

Articles related to Hermaphroditism:

(show top 50) (show all 1392)
# Title Authors PMID Year
1
Insulin-like androgenic gland hormone 1 (IAG1) regulates sexual differentiation in a hermaphrodite shrimp through feedback to neuroendocrine factors. 61
33359802 2021
2
Plant sex: Best to be bisexual when mates are scarce. 61
33756144 2021
3
The rapid dissolution of dioecy by experimental evolution. 61
33472050 2021
4
Enhanced leaky sex expression in response to pollen limitation in the dioecious plant Mercurialis annua. 61
33098734 2021
5
Shy Girl, a kiwifruit suppressor of feminization, restricts gynoecium development via regulation of cytokinin metabolism and signalling. 61
33503269 2021
6
Loss of gill rakers and teeth in adult specimens of barracudina Arctozenus risso (Aulopiformes: Paralepididae) from the western North Atlantic. 61
32985683 2021
7
Interocean patterns in shallow water sponge assemblage structure and function. 61
32812691 2020
8
Ovotesticular Disorder With Seminoma. 61
33489542 2020
9
Adaptive associations among life history, reproductive traits, environment, and origin in the Wisconsin angiosperm flora. 61
33315246 2020
10
Comparative transcriptome analysis of three gonadal development stages reveals potential genes involved in gametogenesis of the fluted giant clam (Tridacna squamosa). 61
33287701 2020
11
LOVE'S BODY AND THE BODY OF LOVE: On Norman O. Brown's Eschatological Hermaphrodite and the Darwinian Continuities of Nature. 61
33021159 2020
12
Roles of gonad-inhibiting hormone in the protandric simultaneous hermaphrodite peppermint shrimp†. 61
32582944 2020
13
46, XX Ovotesticular disorder of sex development (true hermaphroditism) with seminoma: A case report. 61
33019456 2020
14
Evolution of Sex Determination in Amniotes: Did Stress and Sequential Hermaphroditism Produce Environmental Determination? 61
32820558 2020
15
The wild grape genome sequence provides insights into the transition from dioecy to hermaphroditism during grape domestication. 61
32892750 2020
16
Environmental stressors affect sex ratios in sexually dimorphic plant sexual systems. 61
32333831 2020
17
Natural sex change in mature protogynous orange-spotted grouper (Epinephelus coioides): gonadal restructuring, sex hormone shifts and gene profiles. 61
32535923 2020
18
Mature and Bi-Sexual Phase Gonad Occurrence in Cultured Red Spotted Grouper, Epinephelus akaara. 61
33110954 2020
19
Oxygen, life forms, and the evolution of sexes in multicellular eukaryotes. 61
32415185 2020
20
Disorder of Sex Development: A Case of Late-Diagnosed Ovotestis and Its Postsurgical Follow-up. 61
32224245 2020
21
Three patients with 46,X,inv(Y)(p11.2q11.2)pat/45,X and their pedigree analysis. 61
32162681 2020
22
Semimytilus algosus: first known hermaphroditic mussel with doubly uniparental inheritance of mitochondrial DNA. 61
32647112 2020
23
Restriction site-associated DNA sequencing (RAD-seq) analysis in Pacific oyster Crassostrea gigas based on observation of individual sex changes. 61
32555506 2020
24
Sex Determination by Two Y-Linked Genes in Garden Asparagus. 61
32220850 2020
25
Insight into the Possible Formation Mechanism of the Intersex Phenotype of Lanzhou Fat-Tailed Sheep Using Whole-Genome Resequencing. 61
32486017 2020
26
Inbreeding shapes the evolution of marine invertebrates. 61
32191349 2020
27
True hermaphroditism with dysgerminoma: A case report. 61
32481455 2020
28
Ascoma genotyping and mating type analyses of mycorrhizas and soil mycelia of Tuber borchii in a truffle orchard established by mycelial inoculated plants. 61
31393668 2020
29
Sex-specific floral attraction traits in a sequentially hermaphroditic species. 61
32128121 2020
30
A phylogenetic comparative analysis on the evolution of sequential hermaphroditism in seabreams (Teleostei: Sparidae). 61
32107416 2020
31
Nonspecific expression of fertilization genes in the crown-of-thorns Acanthaster cf. solaris: Unexpected evidence of hermaphroditism in a coral reef predator. 61
31837059 2020
32
Case Report: Denys-Drash Syndrome With WT1 Causative Variant Presenting as Atypical Hemolytic Uremic Syndrome. 61
33392118 2020
33
Hermaphroditism in Marijuana (Cannabis sativa L.) Inflorescences - Impact on Floral Morphology, Seed Formation, Progeny Sex Ratios, and Genetic Variation. 61
32670310 2020
34
Spatial Patterns and Drivers of Angiosperm Sexual Systems in China Differ Between Woody and Herbaceous Species. 61
32849756 2020
35
The Diversity and Dynamics of Sex Determination in Dioecious Plants. 61
33519840 2020
36
Gynomonoecy in a mycoheterotrophic orchid Eulophia zollingeri with autonomous selfing hermaphroditic flowers and putatively outcrossing female flowers. 61
33194432 2020
37
Life history traits and reproductive performance of the caridean shrimp Lysmata boggessi, a heavily traded invertebrate in the marine aquarium industry. 61
32002320 2020
38
The "IAG-Switch"-A Key Controlling Element in Decapod Crustacean Sex Differentiation. 61
33013714 2020
39
A Transient Hermaphroditic Stage in Early Male Gonadal Development in Little Yellow Croaker, Larimichthys polyactis. 61
33584533 2020
40
Variability of mitochondrial ORFans hints at possible differences in the system of doubly uniparental inheritance of mitochondria among families of freshwater mussels (Bivalvia: Unionida). 61
31856711 2019
41
Young sex chromosomes in plants and animals. 61
31222890 2019
42
A detailed investigation of the visual system and visual ecology of the Barrier Reef anemonefish, Amphiprion akindynos. 61
31712572 2019
43
Expression patterns of kiss2 and gpr54-2 in Monopterus albus suggest these genes may play a role in sex reversal in fish. 61
31446680 2019
44
Comparative development of staminate and pistillate flowers in the dioecious cactus Opuntia robusta. 61
30852671 2019
45
Hermaphroditism promotes mate diversity in flowering plants. 61
31403705 2019
46
Pollutants released from the pulp paper industry: Aquatic toxicity and their health hazards. 61
31029991 2019
47
Sexually Antagonistic Variation and the Evolution of Dimorphic Sexual Systems. 61
31002570 2019
48
A functional decomposition of sex inconstancy in the dioecious, colonizing plant Mercurialis annua. 61
31081926 2019
49
Does senescence promote fitness in Caenorhabditis elegans by causing death? 61
30639341 2019
50
Low siring success of females with an acquired male function illustrates the legacy of sexual dimorphism in constraining the breakdown of dioecy. 61
30618173 2019

Variations for Hermaphroditism

Expression for Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for Hermaphroditism

Pathways related to Hermaphroditism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.5 SRY NR0B1 AR
2 10.41 SHBG AR
3 10 AMHR2 AMH

GO Terms for Hermaphroditism

Cellular components related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.23 ZFPM2 SRY SOX9 NR0B1 FOXL2 DMRT2

Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.15 ZGLP1 ZFY SRY SOX9 FOXL2 DMRT2
2 regulation of transcription by RNA polymerase II GO:0006357 10.11 ZGLP1 ZFY ZFPM2 SOX9 FOXL2 DMRT2
3 negative regulation of transcription by RNA polymerase II GO:0000122 10.05 ZGLP1 ZFPM2 SRY SOX9 NR0B1 DMRT1
4 positive regulation of transcription, DNA-templated GO:0045893 10.04 ZFPM2 WNT4 SRY SOX9 FOXL2 AR
5 positive regulation of transcription by RNA polymerase II GO:0045944 10.03 ZGLP1 ZFPM2 SRY SOX9 DMRT2 DMRT1
6 cell differentiation GO:0030154 10.02 ZGLP1 ZFPM2 WNT4 SRY SRD5A2 SOX9
7 positive regulation of gene expression GO:0010628 10.01 SRY SOX9 PPM1F AR AMH
8 spermatogenesis GO:0007283 10 ZGLP1 SOX9 NR0B1 DMRT1 AR
9 negative regulation of transcription, DNA-templated GO:0045892 10 ZFPM2 WNT4 SOX9 PPM1F NR0B1 FOXL2
10 positive regulation of focal adhesion assembly GO:0051894 9.63 WNT4 PPM1F
11 female gonad development GO:0008585 9.63 WNT4 AMHR2
12 adrenal gland development GO:0030325 9.62 WNT4 NR0B1
13 gonad development GO:0008406 9.62 NR0B1 AMH
14 Leydig cell differentiation GO:0033327 9.61 NR0B1 AR
15 Sertoli cell development GO:0060009 9.59 SOX9 DMRT1
16 sex determination GO:0007530 9.58 NR0B1 AMH
17 gonadal mesoderm development GO:0007506 9.58 ZFPM2 AMH
18 oocyte development GO:0048599 9.58 ZGLP1 WNT4 DMRT1
19 negative regulation of steroid biosynthetic process GO:0010894 9.56 WNT4 NR0B1
20 male sex determination GO:0030238 9.56 SRY SOX9 NR0B1 DMRT1
21 Mullerian duct regression GO:0001880 9.54 AMHR2 AMH
22 Sertoli cell differentiation GO:0060008 9.54 SOX9 NR0B1 DMRT1
23 male gonad development GO:0008584 9.5 WNT4 SRD5A2 SOX9 NR0B1 DMRT1 AR
24 renal vesicle induction GO:0072034 9.49 WNT4 SOX9
25 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.48 WNT4 AR
26 positive regulation of male gonad development GO:2000020 9.46 ZFPM2 SRY SOX9 DMRT1
27 sex differentiation GO:0007548 9.17 WNT4 SRY SRD5A2 DMRT2 DMRT1 AMHR2

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.91 ZGLP1 ZFY ZFPM2 SRY SOX9 FOXL2
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.87 ZFY SRY SOX9 FOXL2 DMRT2 DMRT1
3 transcription factor binding GO:0008134 9.67 ZFPM2 SRY NR0B1 AR
4 DNA-binding transcription factor activity GO:0003700 9.63 SRY SOX9 FOXL2 DMRT2 DMRT1 AR
5 sequence-specific DNA binding GO:0043565 9.17 ZGLP1 ZFY SOX9 FOXL2 DMRT2 DMRT1
6 androgen binding GO:0005497 8.96 SHBG AR

Sources for Hermaphroditism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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