MCID: HRM002
MIFTS: 41

Hermaphroditism

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Hermaphroditism

Summaries for Hermaphroditism

MalaCards based summary : Hermaphroditism is related to 46,xx sex reversal 1 and 46,xy sex reversal 1. An important gene associated with Hermaphroditism is SRY (Sex Determining Region Y), and among its related pathways/superpathways are Transcription Androgen Receptor nuclear signaling and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Dehydroepiandrosterone and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and uterus, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 77 In biology, a hermaphrodite (/hɜːrˈmæfrədaɪt/) is an organism that has complete or partial reproductive... more...

Related Diseases for Hermaphroditism

Diseases related to Hermaphroditism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 46,xx sex reversal 1 32.7 NR0B1 SOX9 SRY
2 46,xy sex reversal 1 32.7 SOX9 SRY
3 pseudohermaphroditism 32.1 AR SRD5A2 SRY
4 46 xy gonadal dysgenesis 30.8 NR0B1 SOX9 SRY
5 gonadoblastoma 30.5 SOX9 SRY
6 mixed gonadal dysgenesis 30.4 SOX9 SRY
7 gonadal dysgenesis 30.2 NR0B1 SOX9 SRY
8 amenorrhea 30.1 SRY WNT4
9 alopecia, androgenetic, 1 30.0 AR SRD5A2
10 hypospadias 30.0 AR SOX9 SRD5A2 SRY
11 campomelic dysplasia 29.9 SOX9 SRY
12 lipoid congenital adrenal hyperplasia 29.8 NR0B1 SRY
13 gynecomastia 29.8 AR CGA SRY
14 cryptorchidism, unilateral or bilateral 29.6 AR CGA SRY
15 androgen insensitivity syndrome 29.3 AR CGA SRD5A2 SRY
16 palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal 11.7
17 leech infestation 11.1
18 denys-drash syndrome 11.1
19 seminoma 10.3
20 persistent mullerian duct syndrome 10.2 SOX9 SRY
21 frasier syndrome 10.1 SOX9 SRY
22 dysgerminoma 10.1
23 anorchia 10.1 CGA SRY
24 prostatic hyperplasia, benign 10.1 AR SRD5A2
25 gonadal dysgenesis, xy type, with associated anomalies 10.1
26 inguinal hernia 10.1
27 hypogonadotropic hypogonadism 10.1
28 47, xxy 10.1
29 alternating hemiplegia of childhood 10.0 NR0B1 SRY
30 trophoblastic neoplasm 9.9 CGA NR0B1
31 46,xy partial gonadal dysgenesis 9.9 NR0B1 SOX9 SRY
32 complete androgen insensitivity syndrome 9.9 AR CGA SRY
33 pseudovaginal perineoscrotal hypospadias 9.9 AR CGA SRD5A2
34 hydatidiform mole, recurrent, 1 9.8
35 gonadal agenesis 9.8
36 myelodysplastic syndrome 9.8
37 alopecia 9.8
38 male infertility 9.8
39 spinal muscular atrophy 9.8
40 androgenic alopecia 9.8
41 ectopic pregnancy 9.8
42 microphthalmia 9.8
43 sarcoma 9.8
44 infant gynecomastia 9.8
45 acute cystitis 9.8
46 squamous cell carcinoma 9.8
47 embryonal carcinoma 9.8
48 sertoli cell tumor 9.8
49 gestational trophoblastic neoplasm 9.8
50 choriocarcinoma 9.8

Graphical network of the top 20 diseases related to Hermaphroditism:



Diseases related to Hermaphroditism

Symptoms & Phenotypes for Hermaphroditism

MGI Mouse Phenotypes related to Hermaphroditism:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 AR CGA FIGLA NR0B1 SOX9 SRD5A2
2 reproductive system MP:0005389 9.17 AR CGA FIGLA NR0B1 SOX9 SRD5A2

Drugs & Therapeutics for Hermaphroditism

Drugs for Hermaphroditism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 1, Phase 2 53-43-0 9860744
2 Adjuvants, Immunologic Phase 1, Phase 2
3 Immunologic Factors Phase 1, Phase 2
4 DHEA (Dehydroepiandrosterone) Phase 1, Phase 2
5
Epinephrine Approved, Vet_approved 51-43-4 5816
6
Racepinephrine Approved 329-65-7 838
7 Hops Approved Not Applicable
8 Epinephryl borate
9 Adrenergic beta-Agonists
10 Peripheral Nervous System Agents
11 Mydriatics
12 Psychotropic Drugs
13 Anti-Asthmatic Agents
14 Autonomic Agents
15 Adrenergic Agonists
16 Vasoconstrictor Agents
17 Neurotransmitter Agents
18 Sympathomimetics
19 Adrenergic alpha-Agonists
20 Bronchodilator Agents
21 Adrenergic Agents
22 Respiratory System Agents
23 Analgesics
24 Antirheumatic Agents
25 Analgesics, Non-Narcotic
26 Anti-Inflammatory Agents, Non-Steroidal
27 Anti-Inflammatory Agents
28 Vaccines

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer Recruiting NCT02474641 Phase 3
2 Chinese Medicine(Hu Yang Yang Kun Formula) for Primary Ovarian Insufficiency Completed NCT02794948 Phase 1, Phase 2
3 Decision Support for Parents Receiving Information About Child's Rare Disease Completed NCT01875640
4 Qualitative Research on Women With Congenital Adrenal Hyperplasia Completed NCT00559078
5 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
6 National Survey on Asthma Completed NCT00770250
7 Prospective Observational Cohort HIV and STIs Study in Germany Recruiting NCT03884816
8 Generating Evidence for a Support Package to Stabilize Youth Trajectories Out of Homelessness Recruiting NCT03277794 Not Applicable
9 Follow-up of a National Cohort of Melanoma Stage IV and Unresectable Stage III Patients Recruiting NCT02828202
10 Reducing LGBTQ Adolescent Suicide Active, not recruiting NCT02875535 Not Applicable
11 Resilience Against Depression Disparities (Also Known as Resilience Education to Reduce Depression Disparities) Active, not recruiting NCT02986126 Not Applicable
12 Gene Polymorphisms Influencing Steroid Synthesis and Action Withdrawn NCT00485186

Search NIH Clinical Center for Hermaphroditism

Genetic Tests for Hermaphroditism

Anatomical Context for Hermaphroditism

MalaCards organs/tissues related to Hermaphroditism:

42
Testes, Breast, Uterus, Testis, Kidney, Pituitary, Ovary

Publications for Hermaphroditism

Articles related to Hermaphroditism:

(show top 50) (show all 448)
# Title Authors Year
1
True hermaphroditism with seminoma: A case report. ( 30655982 )
2019
2
Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish <i>Synbranchus marmoratus</i> (Synbranchiformes: Synbranchidae). ( 29695033 )
2018
3
CRISPR/Cas9-Mediated Mosaic Mutation of<i>SRY</i>Gene Induces Hermaphroditism in Rabbits. ( 29439141 )
2018
4
Abnormal hermaphroditism in Pellona flavipinnis (Clupeiformes: Pristigasteridae). ( 30267411 )
2018
5
Intersex, Hermaphroditism, and Gonadal Plasticity in Vertebrates: Evolution of the Müllerian Duct and Amh/Amhr2 Signaling. ( 30303691 )
2018
6
Female Pseudo Hermaphroditism: Late Onset Congenital Adrenal Hyperplasia. ( 30465385 )
2018
7
Draft Genome Sequence of Salmacisia buchloA<ana (Basidiomycota), Which Induces Hermaphroditism in Dioecious Buffalograss. ( 28385853 )
2017
8
Histological profiling of gonads depicting protandrous hermaphroditism in Eleutheronema tetradactylum. ( 28474376 )
2017
9
Phase-specific expression of an insulin-like androgenic gland factor in a marine shrimp Lysmata wurdemanni: Implication for maintaining protandric simultaneous hermaphroditism. ( 28235100 )
2017
10
Hermaphroditism: an obsolete diagnosis? ( 28500834 )
2017
11
Hermaphroditism in the dash-and-dot goatfish Parupeneus barberinus. ( 28097655 )
2017
12
Hermaphroditism in the white spot grouper Epinephelus coeruleopunctatus (Pisces: Serranidae) harvested from Padang City waters, Indonesia. ( 28491284 )
2017
13
Persistence of Reduced Androgenic Glands after Protandric Sex Change Suggests a Basis for Simultaneous Hermaphroditism in a Caridean Shrimp. ( 27132133 )
2016
14
Hermaphroditism in a Roman fresco from Herculaneum (first century A.D.), National Archaeological Museum, Naples, Italy. ( 27412518 )
2016
15
&amp;quot;The persistence of memory&amp;quot;-Hermaphroditism in nematodes. ( 27291983 )
2016
16
Gonad development and hermaphroditism in the ascidian Botryllus schlosseri. ( 27228546 )
2016
17
Hermaphroditism in Leonardo da Vinci's Drawing &amp;quot;Angel in the Flesh&amp;quot; (1513-1515). ( 26980592 )
2016
18
Rediscovering hermaphroditism in Grammatidae with the description of the testicular gland in Brazilian Basslet Gramma brasiliensis. ( 27097082 )
2016
19
The Basement Membrane and the Sex Establishment in the Juvenile Hermaphroditism During Gonadal Differentiation of the Gymnocorymbus ternetzi (Teleostei: Characiformes: Characidae). ( 26386207 )
2015
20
Selfish male-determining element favors the transition from hermaphroditism to androdioecy. ( 25643740 )
2015
21
A case of true hermaphroditism presenting as a testicular tumour. ( 25774314 )
2015
22
Direct reciprocity stabilizes simultaneous hermaphroditism at high mating rates: A model of sex allocation with egg trading. ( 26150086 )
2015
23
A persistent organic pollutant related with unusual high frequency of hermaphroditism in the neotropical anuran Physalaemus cuvieri Fitzinger, 1826. ( 24742721 )
2014
24
Embryology and adult urology - Not always mutually exclusive: A case report on true hermaphroditism at an adult urology clinic. ( 25295140 )
2014
25
Evidence of Hermaphroditism and Sex Ratio Distortion in the Fungal Feeding Nematode Bursaphelenchus okinawaensis. ( 25122669 )
2014
26
7- OVOTESTICULAR DSD (TRUE HERMAPHRODITISM). ( 25105460 )
2014
27
A small XY chromosomal region explains sex determination in wild dioecious V. vinifera and the reversal to hermaphroditism in domesticated grapevines. ( 25179565 )
2014
28
Reproductive cycle and strategy of Anodonta anatina (L., 1758): notes on hermaphroditism. ( 23776103 )
2013
29
Molecular phylogeny of broken-back shrimps (genus Lysmata and allies): a test of the 'Tomlinson-Ghiselin' hypothesis explaining the evolution of hermaphroditism. ( 23727055 )
2013
30
Histological and genetic characterization of true hermaphroditism in Korean pigs. ( 23018792 )
2013
31
Linking micromorphism, brooding, and hermaphroditism in brachiopods: insights from Caribbean Argyrotheca (Brachiopoda). ( 23400897 )
2013
32
Phylogenetic perspectives on the evolution of functional hermaphroditism in teleost fishes. ( 23817661 )
2013
33
The role of androdioecy and gynodioecy in mediating evolutionary transitions between dioecy and hermaphroditism in the animalia. ( 23206127 )
2012
34
Sequential hermaphroditism and personality in a clonal vertebrate: the mangrove killifish. ( 22365923 )
2012
35
Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog. ( 23543931 )
2012
36
True hermaphroditism: first evidence of an ovotestis in a cetacean species. ( 20708743 )
2011
37
Back-and-forth hermaphroditism: phylogenetic context of reproductive system evolution in subdioecious Daphne laureola. ( 21644956 )
2011
38
A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat. ( 20861501 )
2011
39
The evolution of hermaphroditism by an infectious male-derived cell lineage: an inclusive-fitness analysis. ( 21750383 )
2011
40
A fungal parasite regulates a putative female-suppressor gene homologous to maize tasselseed2 and causes induced hermaphroditism in male buffalograss. ( 20121446 )
2010
41
Evidence for hermaphroditism in the Squalius alburnoides allopolyploid fish complex. ( 20559019 )
2010
42
Hermaphroditism among dioecious Tagelus plebeius (Lightfoot, 1786) (Mollusca, Psammobiidae) and Iphigenia brasiliana (Lamarck, 1818) (Mollusca, Donacidae) on the Cachoeira River estuary, IlhAcus, Bahia, Brazil. ( 20231968 )
2010
43
Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes. ( 20823339 )
2010
44
Surgical treatment of hermaphroditism: experience with 25 cases. ( 19806042 )
2009
45
Sry-negative XX true hermaphroditism in a roe deer. ( 18524504 )
2009
46
Diagnosis of true hermaphroditism in a fetus with acampomelic campomelic dysplasia. ( 19253311 )
2009
47
Ovotesticular disorder of sexual development (true hermaphroditism). ( 18822450 )
2009
48
Evolutionary perspectives on hermaphroditism in fishes. ( 19684459 )
2009
49
Accessory male investment can undermine the evolutionary stability of simultaneous hermaphroditism. ( 19605385 )
2009
50
Molecular evolution in Panagrolaimus nematodes: origins of parthenogenesis, hermaphroditism and the Antarctic species P. davidi. ( 19149894 )
2009

Variations for Hermaphroditism

Expression for Hermaphroditism

Search GEO for disease gene expression data for Hermaphroditism.

Pathways for Hermaphroditism

GO Terms for Hermaphroditism

Cellular components related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear speck GO:0016607 9.13 AR NR0B1 SRY
2 nuclear transcription factor complex GO:0044798 8.62 SOX9 SRY

Biological processes related to Hermaphroditism according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.93 AR CGA FIGLA SOX9 SRY
2 positive regulation of transcription, DNA-templated GO:0045893 9.87 AR SOX9 SRY WNT4
3 cell differentiation GO:0030154 9.73 FIGLA NR0B1 SOX9 SRD5A2 SRY WNT4
4 transcription initiation from RNA polymerase II promoter GO:0006367 9.72 AR NR0B1 SOX9
5 negative regulation of cell differentiation GO:0045596 9.63 NR0B1 WNT4
6 cell fate commitment GO:0045165 9.62 SOX9 WNT4
7 negative regulation of epithelial cell proliferation GO:0050680 9.62 AR SOX9
8 cellular response to transforming growth factor beta stimulus GO:0071560 9.61 SOX9 WNT4
9 steroid biosynthetic process GO:0006694 9.61 NR0B1 SRD5A2
10 steroid hormone mediated signaling pathway GO:0043401 9.6 AR NR0B1
11 branching involved in ureteric bud morphogenesis GO:0001658 9.59 SOX9 WNT4
12 intracellular receptor signaling pathway GO:0030522 9.58 AR NR0B1
13 epithelial to mesenchymal transition GO:0001837 9.58 SOX9 WNT4
14 adrenal gland development GO:0030325 9.56 NR0B1 WNT4
15 prostate gland development GO:0030850 9.52 AR SOX9
16 gonad development GO:0008406 9.51 CGA NR0B1
17 oocyte development GO:0048599 9.48 FIGLA WNT4
18 Leydig cell differentiation GO:0033327 9.46 AR NR0B1
19 positive regulation of male gonad development GO:2000020 9.43 SOX9 SRY
20 Sertoli cell differentiation GO:0060008 9.4 NR0B1 SOX9
21 renal vesicle induction GO:0072034 9.37 SOX9 WNT4
22 male gonad development GO:0008584 9.35 AR NR0B1 SOX9 SRD5A2 WNT4
23 male sex determination GO:0030238 9.33 NR0B1 SOX9 SRY
24 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.32 AR WNT4
25 hypothalamus development GO:0021854 9.19 NR0B1
26 sex differentiation GO:0007548 8.92 AR SRD5A2 SRY WNT4

Molecular functions related to Hermaphroditism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.55 AR FIGLA NR0B1 SOX9 SRY
2 steroid hormone receptor activity GO:0003707 9.32 AR NR0B1
3 nuclear receptor activity GO:0004879 9.26 AR NR0B1
4 sequence-specific DNA binding GO:0043565 9.26 AR FIGLA NR0B1 SOX9
5 transcription factor binding GO:0008134 8.92 AR FIGLA NR0B1 SRY

Sources for Hermaphroditism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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