Aliases & Classifications for Hernia, Hiatus

MalaCards integrated aliases for Hernia, Hiatus:

Name: Hernia, Hiatus 57
Hiatal Hernia 57 12 29 43
Hiatus Hernia 12 15
Diaphragmatic - Hiatus -Hernia 12
Hernia, Hiatal 44

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
hernia, hiatus:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 142400
Disease Ontology 12 DOID:12642
ICD10 33 K44
MeSH 44 D006551
NCIt 50 C98945
MedGen 42 C3489393
SNOMED-CT via HPO 69 263681008

Summaries for Hernia, Hiatus

MedlinePlus : 43 A hiatal hernia is a condition in which the upper part of your stomach bulges through an opening in your diaphragm. Your diaphragm is the thin muscle that separates your chest from your abdomen. Your diaphragm helps keep acid from coming up into your esophagus. When you have a hiatal hernia, it's easier for the acid to come up. This leaking of acid from your stomach into your esophagus is called GERD (gastroesophageal reflux disease). GERD may cause symptoms such as Heartburn Problems swallowing A dry cough Bad breath Nausea and/or vomiting Breathing problems The wearing away of your teeth Often, the cause of a hiatal hernia is unknown. It may have to do with weakness in the surrounding muscles. Sometimes the cause is an injury or a birth defect. Your risk of getting a hiatal hernia goes up as you age; they are common in people over age 50. You are also at higher risk if you have obesity or smoke. People usually find out that they have a hiatal hernia when they are getting tests for GERD, heartburn, chest pain, or abdominal pain. The tests may be a chest x-ray, an x-ray with a barium swallow, or an upper endoscopy. You don't need treatment if your hiatal hernia does not cause any symptoms or problems. If you do have symptoms, some lifestyle changes may help. They include eating small meals, avoiding certain foods, not smoking or drinking alcohol, and losing weight. Your health care provider may recommend antacids or other medicines. If these don't help, you may need surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Hernia, Hiatus, also known as hiatal hernia, is related to sucrosuria, hiatus hernia and mental retardation and galloway-mowat syndrome. An important gene associated with Hernia, Hiatus is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways is Constitutive Androstane Receptor Pathway. The drugs Calcium polycarbophil and Psyllium have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and small intestine, and related phenotypes are abnormality of the thorax and hiatus hernia

Description from OMIM: 142400

Related Diseases for Hernia, Hiatus

Diseases related to Hernia, Hiatus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 sucrosuria, hiatus hernia and mental retardation 12.1
2 galloway-mowat syndrome 11.9
3 displacement of cardia through esophageal hiatus 11.7
4 gastrocutaneous syndrome 11.3
5 galloway-mowat syndrome 1 11.3
6 ehlers-danlos syndrome, classic-like 11.1
7 fungal esophagitis 10.7 ATP12A ATP4A
8 bladder calculus 10.7 ATP12A ATP4A
9 gastrointestinal neuroendocrine benign tumor 10.7 ATP12A ATP4A
10 neonatal candidiasis 10.7 ATP12A ATP4A
11 photoallergic dermatitis 10.7 ATP12A ATP4A
12 squamous papillomatosis 10.7 ATP12A ATP4A
13 acute laryngitis 10.7 ATP12A ATP4A
14 gastroduodenal crohn's disease 10.7 ATP12A ATP4A
15 gastric neuroendocrine neoplasm 10.7 ATP12A ATP4A
16 toxic megacolon 10.7 ATP12A ATP4A
17 aspiration pneumonitis 10.7 ATP12A ATP4A
18 postsurgical hypothyroidism 10.7 ATP12A ATP4A
19 gastric antral vascular ectasia 10.7 ATP12A ATP4A
20 duodenitis 10.7 ATP12A ATP4A
21 rumination disorder 10.7 ATP12A ATP4A
22 bile reflux 10.7 ATP12A ATP4A
23 granulomatous gastritis 10.6 ATP12A ATP4A
24 active peptic ulcer disease 10.6 ATP12A ATP4A
25 laryngeal disease 10.6 ATP12A ATP4A
26 ischemic neuropathy 10.6 ATP12A ATP4A
27 capillary disease 10.6 ATP12A ATP4A
28 duodenal disease 10.6 ATP12A ATP4A
29 dyskinesia of esophagus 10.6 ATP12A ATP4A
30 congenital disorder of deglycosylation 10.6 ATP12A ATP4A
31 anismus 10.6 ATP12A ATP4A
32 esophageal atresia/tracheoesophageal fistula 10.6 ATP12A ATP4A
33 laryngitis 10.6 ATP12A ATP4A
34 laryngeal tuberculosis 10.6 ATP12A ATP4A
35 lymphocytic colitis 10.6 ATP12A ATP4A
36 clostridium difficile colitis 10.6 ATP12A ATP4A
37 lower urinary tract calculus 10.6 ATP12A ATP4A
38 aspiration pneumonia 10.6 ATP12A ATP4A
39 diarrhea 1, secretory chloride, congenital 10.6 ATP12A ATP4A
40 chronic intestinal vascular insufficiency 10.6 ATP12A ATP4A
41 eosinophilic gastritis 10.5 ATP12A ATP4A
42 polyposis, skin pigmentation, alopecia, and fingernail changes 10.5 ATP12A ATP4A
43 esophageal varix 10.5 ATP12A ATP4A
44 esophagus adenocarcinoma 10.5 ATP12A ATP4A
45 myopathy, x-linked, with excessive autophagy 10.5 ATP12A ATP4A
46 gastric lymphoma 10.5 ATP12A ATP4A
47 pancreatic steatorrhea 10.5 ATP12A ATP4A
48 pneumatosis cystoides intestinalis 10.5 ATP12A ATP4A
49 superior mesenteric artery syndrome 10.5 ATP12A ATP4A
50 jejunoileitis 10.4 ATP12A ATP4A

Graphical network of the top 20 diseases related to Hernia, Hiatus:



Diseases related to Hernia, Hiatus

Symptoms & Phenotypes for Hernia, Hiatus

Symptoms via clinical synopsis from OMIM:

57
Thorax:
hiatus hernia
congenital short esophagus
partial thoracic stomach


Clinical features from OMIM:

142400

Human phenotypes related to Hernia, Hiatus:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the thorax 32 HP:0000765
2 hiatus hernia 32 HP:0002036

Drugs & Therapeutics for Hernia, Hiatus

Drugs for Hernia, Hiatus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Calcium polycarbophil Phase 4
2 Psyllium Nutraceutical Phase 4
3 Pharmaceutical Solutions Phase 2,Not Applicable
4
Nitric Oxide Approved 10102-43-9 145068 160954
5
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
6 Anesthetics ,Not Applicable
7 Calcium, Dietary Not Applicable
8 pancreatin Not Applicable
9 Cola Nutraceutical Not Applicable

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD) Completed NCT00872755 Phase 4
2 Biologic Versus Synthetic Mesh for Treatment of Paraesophageal Hernia Recruiting NCT02242526 Phase 4
3 Transoral Incisionless Fundoplication (TIF) Versus Sham for Treatment of Gastroesophageal Reflux Disease (GERD) Active, not recruiting NCT01110811 Phase 4
4 Phase IV Study of the Impact of Dietary Fibers on Symptoms and Esophageal Motility in Patients With Non-erosive GERD Active, not recruiting NCT01882088 Phase 4 Mucofalk
5 Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh Unknown status NCT01780285 Phase 3
6 Laparoscopic Lightweight Mesh Repair of Large Hiatal Hernias Unknown status NCT01408108 Phase 3
7 Usage of Biological Patch Versus Plastic in the Laparoscopic Repair of Hiatal Hernias Unknown status NCT02328248 Phase 2, Phase 3
8 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
9 Immunologic Factors in Reflux Esophagitis and Barrett’s Esophagus Unknown status NCT00155805
10 Study of Paraesophageal Hernia Repair With Small Intestine Submucosa Unknown status NCT00786084
11 Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital Completed NCT01776827
12 Veritas Laparoscopic Paraesophageal Hiatal Hernia (PEH) Repair Pilot Trial Completed NCT01195545 Not Applicable
13 Follow-up of Patients Operated Upon for Type II-IV Hiatal Hernia Completed NCT01606449
14 GERD Treatment With Transoral Incisionless Fundoplication (TIF) Following Hiatal Hernia Surgery Completed NCT03143608
15 Short Esophagus in Type II-IV Hiatus Hernia Completed NCT01587859
16 Necessity of Esophageal Dissection During Laparoscopic Fundoplication Completed NCT00287612 Not Applicable
17 Effects of Position and a Test Meal on Esophago-gastric Junction Morphology and Function Assessed by High-resolution Impedance Manometry (HRM) Completed NCT02397616
18 The Biologic Basis of Hernia Formation Completed NCT01099033
19 Foreshortened Esophagus and Its Surgical Therapy Completed NCT00507377
20 Use of Strattice Mesh in Paraesophageal Hernia Surgery Completed NCT01678157
21 Minimally Invasive Collis-Nissen for the Treatment of Short Esophagus Completed NCT02288988 Not Applicable
22 Cardiaplication: A Novel Antireflux Operation Completed NCT02060500 Not Applicable
23 Early Increase in Blood Supply in Patients With Barrett's Esophagus Completed NCT01188980
24 Ultrasound Assessment of Gastric Content and Volume Completed NCT02810977
25 Lingual Tonsil Hypertrophy Grading and Its Relation to Sociodemographic Factors and Clinical Symptoms Completed NCT02926014 Not Applicable
26 Antireflux Ablation Therapy (ARAT) for Gastroesophageal Reflux Treatment Recruiting NCT03548298 Not Applicable
27 Registry of Outcomes From AntiReflux Surgery Recruiting NCT02923362
28 Genetic Analysis of Congenital Diaphragmatic Disorders Recruiting NCT01243229
29 Comparison of Laparoscopic Procedures With and Without the Aid of the AutoLap System- a Robotic Camera Holder Recruiting NCT02934542 Not Applicable
30 Mayo Clinic Foregut Surgery Report Card Questionnaire Recruiting NCT02708303
31 Ergonomics of Laparoscopy: Robotic Camera Controlled Versus Human Camera Controlled Recruiting NCT03339960 Not Applicable
32 Esophageal Cancer Risk Registry Recruiting NCT00260585
33 Blind Gastric Tube Placement: Incidence of Malposition Confirmed by Ultrasonography Recruiting NCT03430908
34 Evaluation of MicroRNA Expression in Blood and Cytology for Detecting Barrett's Esophagus and Associated Neoplasia Recruiting NCT02464930
35 Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease Recruiting NCT02400229 Not Applicable
36 Miromatrix Biological Mesh for Hiatal Hernia Repair Active, not recruiting NCT02436681 Not Applicable
37 Randomized EsophyX Versus Sham / Placebo Controlled TIF Trial: The RESPECT Study Active, not recruiting NCT01136980 Not Applicable
38 ACELL Mesh for Paraesophageal Hernia Repair Active, not recruiting NCT03058731
39 Transoral Incisionless Fundoplication (TIF) Registry Study for Treatment of Gastroesophageal Reflux Disease (GERD) Active, not recruiting NCT01118585 Not Applicable
40 Recurrence Rate After Laparoscopic Repair of Large Hiatal Hernia Enrolling by invitation NCT03025932
41 Effects of Combined Surgery on Obstructive Sleep Apnea in Obese Patients: an Open-label Randomized Controlled Clinical Trial Not yet recruiting NCT03227939 Not Applicable
42 Hiatal Interrogation in Sleeve Gastrectomy Not yet recruiting NCT03527810 Not Applicable
43 Demographics and Findings of Upper Endoscopy Patients Terminated NCT00576992
44 Pilot Study: Utilizing Manometry to Assess Radiation-Induced Changes in Esophageal Function Terminated NCT01992068
45 Retrospective TIF Study for Treatment of Gastroesophageal Reflux Disease (GERD). The RetroTIF Study Terminated NCT01327963 Not Applicable
46 Valvuloplasty as Alternative to Toupet Fundoplication for GERD Withdrawn NCT02625077 Not Applicable

Search NIH Clinical Center for Hernia, Hiatus

Cochrane evidence based reviews: hernia, hiatal

Genetic Tests for Hernia, Hiatus

Genetic tests related to Hernia, Hiatus:

# Genetic test Affiliating Genes
1 Hiatal Hernia 29

Anatomical Context for Hernia, Hiatus

MalaCards organs/tissues related to Hernia, Hiatus:

41
Testes, Kidney, Small Intestine, Tonsil, Ovary, Lung, Heart

Publications for Hernia, Hiatus

Articles related to Hernia, Hiatus:

(show top 50) (show all 150)
# Title Authors Year
1
Effects of manipulations to detect sliding hiatal hernia in dogs with brachycephalic airway obstructive syndrome. ( 29094360 )
2018
2
Unilateral lung agenesis, hiatal hernia and atrioventricular septal defect: a rare combination of congenital anomalies. ( 29754141 )
2018
3
One-Stage Laparoscopic Surgery for Pulmonary Sequestration and Hiatal Hernia in a 2-Year-Old Girl. ( 29318104 )
2018
4
Hiatal hernia recurrence following magnetic sphincter augmentation and posterior cruroplasty: intermediate-term outcomes. ( 29340828 )
2018
5
Crus incision without repair is a risk factor for esophageal hiatal hernia after laparoscopic total gastrectomy: a retrospective cohort study. ( 27177954 )
2017
6
Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy with Concomitant Hiatal Hernia Repair: an Unresolved Question. ( 28455802 )
2017
7
What are the differences in the outcome of laparoscopic axial (I) versus paraesophageal (II-IV) hiatal hernia repair? ( 28597286 )
2017
8
A Foreign Body (Toothbrush) in the Esophagus of a Patient with Hiatal Hernia. ( 28512391 )
2017
9
[Evaluating an effectiveness of surgical treatment of gastroesophageal reflux disease combined with hiatal hernia]. ( 28638010 )
2017
10
Swallow-induced esophageal shortening in patients without hiatal hernia is associated with gastroesophageal reflux. ( 29293978 )
2017
11
"Diagnosis" of a hiatal hernia from a CT coronary artery calcium scan. ( 28895189 )
2017
12
Incidence and Risk Factors of Symptomatic Hiatal Hernia Following Resection for Gastric and Esophageal Cancer. ( 29187491 )
2017
13
Simultaneous thoraco-laparoscopic repair of giant hiatal hernias: an alternative approach. ( 26822464 )
2017
14
Mallory Weiss syndrome is not associated with hiatal hernia: a matched case-control study. ( 28007004 )
2017
15
Equal patient satisfaction, quality of life and objective recurrence rate after laparoscopic hiatal hernia repair with and without mesh. ( 28078457 )
2017
16
Modern diagnosis and treatment of hiatal hernias. ( 28828685 )
2017
17
Anorexia nervosa complicated with hiatal hernia and superior mesenteric artery syndrome: A case illustrating the risk of inference observation confusion. ( 29264011 )
2017
18
Long-term results and complications related to Crurasoft<sup>Ar</sup> mesh repair for paraesophageal hiatal hernias. ( 27023877 )
2017
19
Dumbbell-Shaped Activity on Meckel's Scintigraphy Caused by Hiatal Hernia. ( 26673239 )
2016
20
Hill classification is superior to the axial length of a hiatal hernia for assessment of the mechanical anti-reflux barrier at the gastroesophageal junction. ( 27004249 )
2016
21
New findings in fetal valproate syndrome: hiatal hernia, gastric volvulus and ectopic kidney. ( 27012229 )
2016
22
Totally laparoscopic gastrectomy for early gastric cancer accompanied by huge hiatal hernia: A case report. ( 26781529 )
2016
23
Laparoscopic Hiatal Hernia Repair in 221 Patients: Outcomes and Experience. ( 26884676 )
2016
24
Large Hiatal Hernia Compressing the Heart. ( 26704030 )
2016
25
Hiatal hernia with upside-down stomach. Management of acute incarceration: case presentation and review of literature. ( 28275272 )
2016
26
Hiatal hernia on thoracic computed tomography in pulmonary fibrosis. ( 27174889 )
2016
27
Aortogastric Fistula Caused by a Foreign Body in a Hiatal Hernia. ( 27106433 )
2016
28
Technique of Hill's Gastropexy Combined with Sleeve Gastrectomy for Patients with Morbid Obesity and Gastroesophageal Reflux Disease or Hiatal Hernia. ( 26864390 )
2016
29
Hiatal Hernia Repair with Novel Biological Graft Reinforcement. ( 27186066 )
2016
30
The Effect of Laparoscopic Sleeve Gastrectomy with Concomitant Hiatal Hernia Repair on Gastroesophageal Reflux Disease in the Morbidly Obese. ( 25990380 )
2016
31
Results of left thoracoscopic Collis gastroplasty with laparoscopic Nissen fundoplication for the surgical treatment of true short oesophagus in gastro-oesophageal reflux disease and Type III-IV hiatal hernia. ( 26518379 )
2016
32
Hiatal hernia, mitral valve prolapse and defecatory disorders: An underlying rectal prolapse? ( 26925980 )
2016
33
Hiatal hernias are correlated with increased severity of non-cystic fibrosis bronchiectasis. ( 25872951 )
2015
34
Echocardiography Is Essential in Detection of Cardiac Tamponade Due to Sliding Hiatal Hernia. ( 26275523 )
2015
35
Incidental physiological sliding hiatal hernia: a single center comparison study between CT with water enema and CT colonography. ( 25690708 )
2015
36
Robotic giant hiatal hernia repair: 3a88year prospective evaluation and review of the literature. ( 24869751 )
2015
37
De novo hiatal hernia of the gastric tube after sleeve gastrectomy. ( 26318133 )
2015
38
Umbilical hernia with cholelithiasis and hiatal hernia: a clinical entity similar to Saint's triad. ( 26366362 )
2015
39
Resorbable biosynthetic mesh for crural reinforcement during hiatal hernia repair. ( 25264654 )
2014
40
Laparoscopic hiatal hernia repair. Is the mesh hiatoplasty justified? ( 23685345 )
2014
41
Hiatal hernia repair in laparoscopic adjustable gastric banding and laparoscopic Roux-en-Y gastric bypass: a national database analysis. ( 24307434 )
2014
42
[Results of surgical treatment of hiatal hernia]. ( 23115031 )
2014
43
Gastric dilatation and volvulus in a brachycephalic dog with hiatal hernia. ( 24871205 )
2014
44
Postoperative intussusception in a neonate with congenital cutis laxa and huge hiatal hernia. ( 24834384 )
2014
45
Chest pain due to hiatal hernia mimicking as cardiac mass. ( 24654739 )
2014
46
Modification of Belsey (Mark IV) fundoplication in the management of hiatal hernia and gastroesophageal reflux disease after sleeve gastrectomy: a case report. ( 25820076 )
2014
47
Hiatal Hernia Mimicking ST Elevation Myocardial Infarction. ( 25402752 )
2014
48
The effect of laparoscopic sleeve gastrectomy with or without hiatal hernia repair on gastroesophageal reflux disease in obese patients. ( 24355324 )
2013
49
Sleeve gastrectomy and crural repair in obese patients with gastroesophageal reflux disease and/or hiatal hernia. ( 22867558 )
2013
50
Incidental finding on a SPECT/CT of a retroperitoneal leiomyosarcoma imitating a hiatal hernia in 131I whole-body scan in thyroid cancer evaluation. ( 23850374 )
2013

Variations for Hernia, Hiatus

Expression for Hernia, Hiatus

Search GEO for disease gene expression data for Hernia, Hiatus.

Pathways for Hernia, Hiatus

Pathways related to Hernia, Hiatus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 CYP2C19 NCOA2

GO Terms for Hernia, Hiatus

Biological processes related to Hernia, Hiatus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import GO:0010107 9.37 ATP12A ATP4A
2 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
4 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
5 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Hernia, Hiatus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monooxygenase activity GO:0004497 9.16 CYP2C19 PAM
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Hernia, Hiatus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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