MCID: HRP001
MIFTS: 44

Herpangina

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Herpangina

MalaCards integrated aliases for Herpangina:

Name: Herpangina 12 73 44 15 17 70
Vesicular Pharyngitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10883
ICD9CM 34 074.0
MeSH 44 D006557
SNOMED-CT 67 154358007
ICD10 32 B08.5
UMLS 70 C0019338

Summaries for Herpangina

Disease Ontology : 12 A viral infectious disease that results in infection located in mouth, has material basis in Human coxsackievirus A16, has material basis in Human enterovirus 71, has material basis in group B coxsackievirus, or has material basis in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

MalaCards based summary : Herpangina, also known as vesicular pharyngitis, is related to hand, foot and mouth disease and mouth disease. An important gene associated with Herpangina is MFSD6 (Major Facilitator Superfamily Domain Containing 6), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 73 Herpangina, also called mouth blisters, is a painful mouth infection caused by coxsackieviruses.... more...

Related Diseases for Herpangina

Diseases related to Herpangina via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 643)
# Related Disease Score Top Affiliating Genes
1 hand, foot and mouth disease 31.0 TLR7 TLR3 IL6 IL10 DDX58
2 mouth disease 30.7 TLR7 TLR3 IL6 IL10 IFNA1 H2AC18
3 pharyngitis 30.5 TNF IL6 CD8A CD4
4 herpes simplex 30.4 TLR9 TLR3 IFNB1 IFNA1 DDX58
5 erythema multiforme 30.3 TNF IL6 IL2
6 encephalitis 30.1 TNF TLR3 IL6 IL10 IFNB1 DDX58
7 meningitis 30.0 TNF TLR9 IL6 IL2 IL10
8 thyroiditis 30.0 TNF IL6 IL2 IL10 IFNA1
9 meningoencephalitis 30.0 TNF IL6 IL10 CD8A CD4 CCR6
10 myelitis 29.9 TNF IL6 IL10 IFNB1 ICOSLG CCR6
11 diarrhea 29.9 TNF IL6 IL2 IL10 IFNB1 IFNA1
12 poliomyelitis 29.8 TNF TLR3 IL10 IFNA1 DDX58 CD8A
13 influenza 29.8 TNF TLR7 TLR3 IL6 IFNB1 IFNA1
14 herpes zoster 29.6 TNF TLR3 IL2 IL10 IFNA1 ICOSLG
15 stomatitis 29.6 TNF IL6 IL2 IL10 IFNB1 IFNA1
16 disease by infectious agent 29.6 TNF TLR9 TLR7 IL6 IL2 IL10
17 exanthem 29.4 TNF IL6 IL2 IL10 IFNA1 ICOSLG
18 cork-handlers' disease 10.5 CD8A CD4
19 necrotic uveal melanoma 10.5 CD8A CD4
20 early yaws 10.5 CD8A CD4
21 oral erosive lichen 10.5 IFNB1 IFNA1
22 adult acute lymphocytic leukemia 10.5 CD8A CD4 CCR6
23 ventilation pneumonitis 10.5 CD8A CD4
24 esophageal candidiasis 10.5 CD8A CD4 CCR6
25 diffuse infiltrative lymphocytosis syndrome 10.5 CD8A CD4
26 autoimmune cholangitis 10.5 CD8A CD4 CCR6
27 borst-jadassohn intraepidermal carcinoma 10.5 TLR7 CD8A CD4
28 west nile fever 10.5 IFNA1 CD8A CD4
29 monkeypox 10.5 IFNA1 CD8A CD4
30 latent syphilis 10.5 CD8A CD4
31 herpes simplex virus keratitis 10.5 IFNB1 CD4 CCR6
32 wissler-fanconi syndrome 10.5 IFNA1 CD4
33 autoimmune lymphoproliferative syndrome, type iia 10.5 CD8A CD4
34 goodpasture syndrome 10.4 H2AC18 CD4 CCR6
35 external pathological resorption 10.4 TNF IL6
36 parasitic ectoparasitic infectious disease 10.4 H2AC18 CD4 CCR6
37 bell's palsy 10.4 TLR3 CD8A CD4
38 type 1 diabetes mellitus 23 10.4 TNF CD8A CD4
39 punctate inner choroidopathy 10.4 TNF IL10
40 cerebritis 10.4 TNF CD8A CD4
41 granulomatous hepatitis 10.4 TNF CD8A CD4
42 viral exanthem 10.4 TNF CD8A CD4
43 granulomatous dermatitis 10.4 TNF CD8A CD4
44 neurosarcoidosis 10.4 TNF CD8A CD4
45 uveoparotid fever 10.4 TNF CD8A CD4
46 scorpion envenomation 10.4 TNF IL6
47 blastomycosis 10.4 IL6 CD4 CCR6
48 physiological polycythemia 10.4 TNF IL6
49 pneumonic plague 10.4 TNF CD8A CD4
50 mikulicz disease 10.4 IL10 CD4 CCR6

Graphical network of the top 20 diseases related to Herpangina:



Diseases related to Herpangina

Symptoms & Phenotypes for Herpangina

MGI Mouse Phenotypes related to Herpangina:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 AMHR2 CCR6 CD4 CD8A DDX58 IFNB1
2 homeostasis/metabolism MP:0005376 10 AMHR2 CCR6 CD4 DDX58 GP5 IFNB1
3 immune system MP:0005387 9.8 AMHR2 CCR6 CD4 CD8A DDX58 IFNB1
4 neoplasm MP:0002006 9.23 AMHR2 DDX58 IFNB1 IL10 IL2 IL6

Drugs & Therapeutics for Herpangina

Drugs for Herpangina (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 4 36791-04-5 37542
2 Anti-Infective Agents Phase 4
3 Antiviral Agents Phase 4
4 interferons Phase 4
5 Antimetabolites Phase 4
6 Vaccines Phase 3
7
Acetaminophen Approved Phase 2 103-90-2 1983
8
Sucralfate Approved Phase 2 54182-58-0
9
Ibuprofen Approved Phase 2 15687-27-1 3672
10 Analgesics, Non-Narcotic Phase 2
11 Gastrointestinal Agents Phase 2
12 Analgesics Phase 2
13 Pharmaceutical Solutions Phase 2
14 Antirheumatic Agents Phase 2
15 Cyclooxygenase Inhibitors Phase 2
16 Anti-Inflammatory Agents Phase 2
17 Anti-Ulcer Agents Phase 2
18 Antipyretics Phase 2
19 Antacids Phase 2
20 Anti-Inflammatory Agents, Non-Steroidal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect and Safety of Recombinant Human Interferon α-2b Spray on Herpangina in Pediatric Patients Completed NCT03266601 Phase 4 Recombinant Human Interferon α-2b Spray;Ribavirin
2 A Multiple-center Randomized Double-blind Placebo-controlled Phase 3 Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months Completed NCT01508247 Phase 3
3 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Unknown status NCT03241030 Phase 2 Sucralfate;Acetaminophen;Ibuprofen

Search NIH Clinical Center for Herpangina

Cochrane evidence based reviews: herpangina

Genetic Tests for Herpangina

Anatomical Context for Herpangina

MalaCards organs/tissues related to Herpangina:

40
Brain, Heart

Publications for Herpangina

Articles related to Herpangina:

(show top 50) (show all 267)
# Title Authors PMID Year
1
The epidemiological characteristics of enterovirus infection before and after the use of enterovirus 71 inactivated vaccine in Kunming, China. 61
33682641 2021
2
Enterovirus A71 Vaccines. 61
33673595 2021
3
Intrinsic apoptosis and cytokine induction regulated in human tonsillar epithelial cells infected with enterovirus A71. 61
33481814 2021
4
Inhibition of Enterovirus A71 by a Novel 2-Phenyl-Benzimidazole Derivative. 61
33406781 2021
5
Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010-2018. 61
33295885 2020
6
Weather condition, air pollutants, and epidemics as factors that potentially influence the development of Kawasaki disease. 61
32610244 2020
7
A Different Epidemiology of Enterovirus A and Enterovirus B Co-circulating in Korea, 2012-2019. 61
33150450 2020
8
Genetic Diversity Analysis of Coxsackievirus A8 Circulating in China and Worldwide Reveals a Highly Divergent Genotype. 61
32977444 2020
9
Evaluation of the diagnostic performance and its associated factors of a commercial anti-EV-A71 IgM-capture ELISA kit in hospitalized children with clinical diagnostic HFMD. 61
32795960 2020
10
Mosaic genome of Human Coxsackievirus A4 associated with herpangina and HFMD in Yancheng, China, 2016 and 2018. 61
32439540 2020
11
Lack of effective home quarantine: The cause of the continuing prevalence of hand, foot, and mouth disease in China? 61
32473816 2020
12
Diagnosis and treatment of herpangina: Chinese expert consensus. 61
31347021 2020
13
[Atypical hand-foot-mouth disease virus genotyping in a pediatric hospital in Buenos Aires city, Argentina]. 61
32199065 2020
14
Molecular epidemiology and clinical characteristics of herpangina children in Beijing, China: a surveillance study. 61
33088614 2020
15
Establishment of Asia-Pacific Network for Enterovirus Surveillance. 61
31679864 2020
16
The Structure, Function, and Mechanisms of Action of Enterovirus Non-structural Protein 2C. 61
33381104 2020
17
Comparative Efficacy of Chinese Herbal Injections for the Treatment of Herpangina: A Bayesian Network Meta-Analysis of Randomized Controlled Trials. 61
32477147 2020
18
Novel Naturally Occurring Mutations of Enterovirus 71 Associated With Disease Severity. 61
33519765 2020
19
Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model. 61
31711481 2019
20
Molecular epidemiology of enterovirus from children with herpangina or hand, foot, and mouth disease in Hangzhou, 2016. 61
31321585 2019
21
Nationwide Survey of Pediatric Inpatients With Hand, Foot, and Mouth Disease, Herpangina, and Associated Complications During an Epidemic Period in Japan: Estimated Number of Hospitalized Patients and Factors Associated With Severe Cases. 61
30416163 2019
22
Antivirals and vaccines for Enterovirus A71. 61
31481071 2019
23
Comparison of Nonpolio Enteroviruses in Children With Herpangina and Hand, Foot and Mouth Disease in Taiwan. 61
31033911 2019
24
Case report: painful exanthems caused by enterovirus D68 in an adolescent. 61
31415349 2019
25
Recombinant CV-A6 strains related to hand-foot-mouth disease and herpangina at primary care centers (Barcelona, Spain). 61
31033351 2019
26
Advances in Antigenic Peptide-Based Vaccine and Neutralizing Antibodies against Viruses Causing Hand, Foot, and Mouth Disease. 61
30871133 2019
27
[Expert consensus on diagnosis and treatment of herpangina (version 2019)]. 61
30818893 2019
28
Phylogenetic and antigenic analyses of coxsackievirus A6 isolates in Yamagata, Japan between 2001 and 2017. 61
30683510 2019
29
Near-Complete Genome Sequences of 12 Coxsackievirus Group A Strains from Hand, Foot, and Mouth Disease and Herpangina Cases with Different Clinical Symptoms. 61
30834371 2019
30
Acute gingivostomatitis in children: Epidemiology in the emergency department, pain, and use of codeine before its restriction. 61
30638927 2019
31
Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007. 61
31622436 2019
32
Characterization of an inactivated whole-virus bivalent vaccine that induces balanced protective immunity against coxsackievirus A6 and A10 in mice. 61
30316529 2018
33
Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development. 61
30427405 2018
34
Molecular epidemiology of coxsackievirus A6 circulating in Hong Kong reveals common neurological manifestations and emergence of novel recombinant groups. 61
30237097 2018
35
Sex differences in common childhood infections in Taiwan. 61
30170156 2018
36
Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. 61
30255146 2018
37
Factors associated with severe neurologic complications in patients with either hand-foot-mouth disease or herpangina: A nationwide observational study in South Korea, 2009-2014. 61
30096160 2018
38
Understanding physician antibiotic prescribing behavior for children with enterovirus infection. 61
30192893 2018
39
Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population. 61
29323107 2018
40
Seroepidemiology of coxsackievirus B5 in infants and children in Jiangsu province, China. 61
29049009 2018
41
Persistent circulation of genotype D coxsackievirus A2 in mainland of China since 2008. 61
30235342 2018
42
Detection of Saffold viruses from children with acute respiratory infections in Yamagata, Japan, between 2008 and 2015. 61
28851118 2018
43
Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children. 61
28970483 2017
44
[Clinical characteristics and course of hand, foot, and mouth disease]. 61
28893485 2017
45
Cost-effectiveness of a national enterovirus 71 vaccination program in China. 61
28892475 2017
46
Characterization of genome sequences and clinical features of coxsackievirus A6 strains collected in Hyogo, Japan in 1999-2013. 61
28229467 2017
47
Protective Efficacies of Formaldehyde-Inactivated Whole-Virus Vaccine and Antivirals in a Murine Model of Coxsackievirus A10 Infection. 61
28424287 2017
48
Management of viral oral ulcers in children using Chinese herbal medicine: A report of two cases. 61
28619306 2017
49
Prevalence and molecular characterization of human rhinovirus in stool samples of individuals with and without acute gastroenteritis. 61
27678016 2017
50
Epidemiological and etiological characteristics of herpangina and hand foot mouth diseases in Jiangsu, China, 2013-2014. 61
27768527 2017

Variations for Herpangina

Expression for Herpangina

Search GEO for disease gene expression data for Herpangina.

Pathways for Herpangina

Pathways related to Herpangina according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 TNF TLR9 TLR8 TLR7 TLR3 IL6
2
Show member pathways
13.7 TNF IL6 IL2 IL10 IFNB1 IFNA1
3
Show member pathways
13.46 TNF TLR9 TLR8 TLR7 TLR3 IL6
4
Show member pathways
13.37 TNF IL6 IL2 IL10 IFNB1 IFNA1
5
Show member pathways
13.17 TNF TLR9 TLR8 TLR7 TLR3 IL6
6
Show member pathways
13.01 TNF TLR3 IL6 IL2 IFNB1 IFNA1
7
Show member pathways
12.96 TNF TLR3 IL6 IFNB1 IFNA1 CD4
8
Show member pathways
12.88 TNF IL6 IL2 IL10 IFNA1 ICOSLG
9 12.87 TNF TLR9 TLR3 IL6 IFNB1 IFNA1
10
Show member pathways
12.84 TNF TLR9 TLR7 TLR3 IL6 IL2
11
Show member pathways
12.77 TNF TLR9 TLR8 TLR7 TLR3 IL6
12
Show member pathways
12.76 TNF TLR9 TLR8 TLR7 TLR3 IL6
13
Show member pathways
12.68 TNF TLR9 IL6 IL2 IL10 CD8A
14
Show member pathways
12.66 TNF IL2 IL10 ICOSLG CD4
15
Show member pathways
12.61 TNF IL6 IL2 IL10 CD4
16
Show member pathways
12.61 TNF IL6 IL2 IL10 CD4
17
Show member pathways
12.6 TNF TLR9 TLR8 TLR7 TLR3
18
Show member pathways
12.57 TLR3 IL6 IFNB1 IFNA1 DDX58
19
Show member pathways
12.45 IL6 IL2 IL10 IFNB1 IFNA1
20
Show member pathways
12.38 TNF IL6 IL2 IL10 CCR6
21 12.37 TNF TLR9 TLR8 TLR7 TLR3 IL2
22 12.35 TNF IL6 IL2 CD4
23
Show member pathways
12.33 TNF TLR9 TLR8 TLR7 TLR3 IL6
24
Show member pathways
12.32 TNF IL6 IL2 IL10 IFNB1 IFNA1
25 12.32 TNF TLR9 IL6 IL10 IFNB1 IFNA1
26
Show member pathways
12.29 TNF TLR9 TLR8 IL6 IL2 IL10
27
Show member pathways
12.27 TNF TLR3 IFNB1 IFNA1 H2AC18
28 12.26 TNF IL6 IFNB1 IFNA1
29 12.25 TNF TLR9 TLR8 TLR7 TLR3 IL6
30
Show member pathways
12.24 TNF TLR9 TLR8 TLR7 IL6 IFNB1
31
Show member pathways
12.11 TLR9 TLR8 TLR7 TLR3 IL2
32 12.05 TNF IL6 IL2 IL10 IFNB1 CD8A
33 11.99 TNF IL6 GP5 CD8A CD4
34
Show member pathways
11.93 TLR9 TLR8 TLR7 TLR3 IL6 CD4
35 11.93 TNF IL6 IL2 IL10 GP5 CD8A
36 11.88 TLR9 TLR8 TLR7 TLR3
37 11.84 TNF IL2 IL10 CD8A CD4 CCR6
38 11.77 TNF IL6 IL10
39 11.7 TNF TLR9 IL6 IL10 ICOSLG CCR6
40
Show member pathways
11.68 TNF IL6 IL2
41
Show member pathways
11.66 TNF IL2 CD8A
42 11.63 TNF TLR9 IL6 IL10
43 11.58 TNF IL6 IL2
44 11.56 TNF IL6 IL10
45 11.54 IL6 IFNB1 IFNA1
46 11.52 IL2 IL10 CD4
47
Show member pathways
11.49 TNF TLR9 TLR8 TLR7 TLR3 IL6
48 11.48 TNF TLR9 IL6 IL10
49
Show member pathways
11.4 TNF IL2 IL10
50 11.38 TNF IL6 IL10

GO Terms for Herpangina

Cellular components related to Herpangina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.43 TNF TLR8 ICOSLG CD8A CD4 CCR6
2 early phagosome GO:0032009 9.16 TLR9 TLR7
3 endolysosome membrane GO:0036020 8.92 TLR9 TLR8 TLR7 TLR3

Biological processes related to Herpangina according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.33 TLR9 TLR8 TLR7 TLR3 IL6 IL10
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.23 TNF TLR9 TLR3 IL6 IL2 IL10
3 immune system process GO:0002376 10.18 TLR9 TLR8 TLR7 TLR3 IL2 ICOSLG
4 positive regulation of gene expression GO:0010628 10.12 TNF TLR9 TLR3 IL6 DDX58
5 adaptive immune response GO:0002250 10.11 IL2 IFNB1 IFNA1 ICOSLG CD8A CD4
6 inflammatory response GO:0006954 10.09 TNF TLR9 TLR8 TLR7 TLR3 IL6
7 cytokine-mediated signaling pathway GO:0019221 10.05 TNF IL6 IL2 IL10 IFNB1 IFNA1
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 TNF TLR9 TLR3 CD4
9 defense response GO:0006952 9.98 TNF TLR3 IFNB1 IFNA1 ICOSLG
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TLR9 TLR3 IL6
11 response to virus GO:0009615 9.97 TNF TLR8 TLR3 IFNB1 DDX58
12 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR9 TLR7 TLR3 IL2
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.94 TNF IL6 IL10 DDX58
14 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR9 TLR3 IL6 DDX58
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.9 TNF TLR9 TLR7 TLR3
16 cellular response to mechanical stimulus GO:0071260 9.89 TLR8 TLR7 TLR3
17 B cell differentiation GO:0030183 9.89 IL10 IFNB1 IFNA1
18 negative regulation of interleukin-6 production GO:0032715 9.89 TNF TLR9 IL10
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.89 TNF IL6 IL2
20 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10
21 toll-like receptor signaling pathway GO:0002224 9.88 TLR9 TLR8 TLR7 TLR3
22 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.88 TNF TLR9 TLR8 TLR7 TLR3
23 regulation of protein phosphorylation GO:0001932 9.87 TNF TLR8 TLR7
24 positive regulation of T cell proliferation GO:0042102 9.87 IL6 IL2 CD4
25 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF TLR8 IL6
26 response to exogenous dsRNA GO:0043330 9.86 TLR3 IFNB1 IFNA1 DDX58
27 defense response to virus GO:0051607 9.86 TLR9 TLR8 TLR7 TLR3 IL6 IFNB1
28 positive regulation of cytokine production GO:0001819 9.85 TNF TLR3 IL10
29 humoral immune response GO:0006959 9.85 TNF IL6 IFNB1 IFNA1 CCR6
30 T cell activation GO:0042110 9.84 ICOSLG CD8A CD4
31 microglial cell activation GO:0001774 9.84 TNF TLR8 TLR7 TLR3
32 B cell proliferation GO:0042100 9.83 IL10 IFNB1 IFNA1
33 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 IL10
34 positive regulation of chemokine production GO:0032722 9.83 TNF TLR9 TLR7 TLR3 IL6
35 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.82 TLR9 TLR8 TLR7
36 positive regulation of immunoglobulin production GO:0002639 9.8 TLR9 IL6 IL2 IL10
37 positive regulation of interferon-beta production GO:0032728 9.8 TLR9 TLR8 TLR7 TLR3 DDX58
38 positive regulation of interferon-gamma production GO:0032729 9.8 TNF TLR9 TLR8 TLR7 TLR3 IL2
39 cellular response to exogenous dsRNA GO:0071360 9.79 TLR3 IFNB1 DDX58
40 toll-like receptor 9 signaling pathway GO:0034162 9.78 TLR9 TLR8 TLR7
41 I-kappaB phosphorylation GO:0007252 9.77 TLR9 TLR7 TLR3
42 positive regulation of interferon-alpha production GO:0032727 9.77 TLR9 TLR8 TLR7 TLR3 DDX58
43 response to molecule of bacterial origin GO:0002237 9.72 TLR9 IL10
44 negative regulation of lipid storage GO:0010888 9.71 TNF IL6
45 hyperosmotic response GO:0006972 9.71 TLR3 ICOSLG
46 necroptotic signaling pathway GO:0097527 9.7 TNF TLR3
47 endothelial cell apoptotic process GO:0072577 9.7 TNF IL10
48 regulation of cytokine secretion GO:0050707 9.7 TLR9 TLR8
49 positive regulation of interleukin-6 production GO:0032755 9.7 TNF TLR9 TLR8 TLR7 TLR3 IL6
50 vascular endothelial growth factor production GO:0010573 9.69 TNF IL6

Molecular functions related to Herpangina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.67 TLR8 TLR3 CD4 CCR6
2 transmembrane signaling receptor activity GO:0004888 9.65 TLR9 TLR8 TLR7 TLR3 CD4
3 single-stranded RNA binding GO:0003727 9.5 TLR8 TLR7 DDX58
4 double-stranded RNA binding GO:0003725 9.46 TLR8 TLR7 TLR3 DDX58
5 siRNA binding GO:0035197 9.4 TLR9 TLR7
6 pattern recognition receptor activity GO:0038187 9.13 TLR9 TLR8 TLR7
7 cytokine activity GO:0005125 9.1 TNF IL6 IL2 IL10 IFNB1 IFNA1

Sources for Herpangina

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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