Aliases & Classifications for Herpangina

Summaries for Herpangina

Disease Ontology : 12 A viral infectious disease that results in infection located in mouth, has material basis in Human coxsackievirus A16, has material basis in Human enterovirus 71, has material basis in group B coxsackievirus, or has material basis in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

MalaCards based summary : Herpangina, also known as vesicular pharyngitis, is related to hand, foot and mouth disease and mouth disease, and has symptoms including fever, sore throat and lesions in the back area of the mouth. An important gene associated with Herpangina is CA4 (Carbonic Anhydrase 4), and among its related pathways/superpathways is Nitrogen metabolism. The drugs Ribavirin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include mouth and tongue.

Wikipedia : 76 Herpangina, also called mouth blisters, is a painful mouth infection caused by coxsackieviruses.... more...

Related Diseases for Herpangina

Diseases related to Herpangina via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hand, foot and mouth disease 28.3 C4A CA10 SCARB2
2 mouth disease 10.5
3 epidemic pleurodynia 10.0
4 parotitis 9.8
5 pharyngitis 9.8
6 influenza 9.8
7 herpes simplex 9.8
8 encephalitis 9.8
9 stomatitis 9.8

Graphical network of the top 20 diseases related to Herpangina:



Diseases related to Herpangina

Symptoms & Phenotypes for Herpangina

Symptoms:

12
  • fever
  • sore throat
  • lesions in the back area of the mouth

Drugs & Therapeutics for Herpangina

Drugs for Herpangina (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 4 36791-04-5 37542
2 Anti-Infective Agents Phase 4
3 Antimetabolites Phase 4
4 Antiviral Agents Phase 4
5 Interferon-alpha Phase 4
6 interferons Phase 4
7 Vaccines Phase 3
8
Acetaminophen Approved Phase 2 103-90-2 1983
9
Ibuprofen Approved Phase 2 15687-27-1 3672
10
Sucralfate Approved Phase 2 54182-58-0 0
11 Analgesics Phase 2
12 Analgesics, Non-Narcotic Phase 2
13 Antacids Phase 2
14 Anti-Inflammatory Agents Phase 2
15 Anti-Inflammatory Agents, Non-Steroidal Phase 2
16 Antipyretics Phase 2
17 Antirheumatic Agents Phase 2
18 Anti-Ulcer Agents Phase 2
19 Cyclooxygenase Inhibitors Phase 2
20 Gastrointestinal Agents Phase 2
21 Peripheral Nervous System Agents Phase 2
22 Pharmaceutical Solutions Phase 2
23 Grape Approved, Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Recombinant Human Interferon α-2b Spray on Herpangina Recruiting NCT03266601 Phase 4 Recombinant Human Interferon α-2b Spray;Ribavirin
2 A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months Completed NCT01508247 Phase 3
3 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Enrolling by invitation NCT03241030 Phase 2 Sucralfate;Acetaminophen;Ibuprofen
4 Do Traditional or Flavored Tongue Depressors Make for Easier Posterior Oropharynx Exams in Pediatric Patients Completed NCT03095183 Not Applicable
5 Neurodevelopment Outcomes Following Severe Hand Foot and Mouth Disease in Vietnam Completed NCT02066714

Search NIH Clinical Center for Herpangina

Cochrane evidence based reviews: herpangina

Genetic Tests for Herpangina

Anatomical Context for Herpangina

The Foundational Model of Anatomy Ontology organs/tissues related to Herpangina:

19
Mouth

MalaCards organs/tissues related to Herpangina:

41
Tongue

Publications for Herpangina

Articles related to Herpangina:

(show top 50) (show all 59)
# Title Authors Year
1
Herpangina ( 29939569 )
2018
2
High prevalence of coxsackievirus A2 in children with herpangina in Thailand in 2015. ( 28466062 )
2017
3
Epidemiological and Etiological Characteristics of Herpangina and Hand Foot Mouth Diseases in Jiangsu, China, 2013-2014. ( 27768527 )
2016
4
Diagnostic uncertainty of herpangina and hand-foot-and-mouth disease and its impact on national enterovirus syndromic monitoring. ( 26593706 )
2016
5
Large outbreak of herpangina in children caused by enterovirus in summer of 2015 in Hangzhou, China. ( 27752104 )
2016
6
Enterovirus-related diarrhoea in Guangdong, China: clinical features and implications in hand, foot and mouth disease and herpangina. ( 26983856 )
2016
7
Molecular epidemiology of the enteroviruses associated with hand, foot and mouth disease/herpangina in Dongguan, China, 2015. ( 27654666 )
2016
8
An outbreak of Kingella kingae infections associated with hand, foot and mouth disease/herpangina virus outbreak in Marseille, France, 2013. ( 25742075 )
2015
9
PREVALENCE OF HUMAN ENTEROVIRUS AMONG PATIENTS WITH HAND, FOOT, AND MOUTH DISEASE AND HERPANGINA IN THAILAND, 2013. ( 26867359 )
2015
10
Genomic characteristics of coxsackievirus A8 strains associated with hand, foot, and mouth disease and herpangina. ( 26483280 )
2015
11
Prevalence and characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenza like illness in Thailand, 2012. ( 24887237 )
2014
12
Neurological Images and the Predictors for Neurological Sequelae of Epidemic Herpangina/Hand-Foot-Mouth Disease with Encephalomyelitis. ( 24258524 )
2013
13
Outbreak of herpangina in the Brazilian Amazon in 2009 caused by Enterovirus B. ( 24197788 )
2013
14
Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children. ( 22985487 )
2012
15
Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. ( 22404077 )
2012
16
Risk factors for hand, foot, and mouth disease and herpangina and the preventive effect of hand-washing. ( 21422083 )
2011
17
Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. ( 22239028 )
2011
18
Increased risk of adverse pregnancy outcomes among women affected by herpangina. ( 20417474 )
2010
19
Prevalence of enterovirus from patients with herpangina and hand, foot and mouth disease in Nagano Prefecture, Japan, 2007. ( 18503184 )
2008
20
Enterovirus detection status of patients with herpangina and hand, foot and mouth disease in epidemic season 2007, Kanagawa Prefecture, Japan. ( 18362414 )
2008
21
Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. ( 17671037 )
2007
22
Differences in replication capacity between enterovirus 71 isolates obtained from patients with encephalitis and those obtained from patients with herpangina in Taiwan. ( 17133556 )
2007
23
Enterovirus detection status from patients with herpangina and hand, foot and mouth disease in Kanagawa Prefecture, Japan. ( 17314432 )
2007
24
Prevalence of coxsackievirus A5, A6, and A10 in patients with herpangina in Aichi Prefecture, 2005. ( 16377876 )
2005
25
Seasonal models of herpangina and hand-foot-mouth disease to simulate annual fluctuations in urban warming in Tokyo. ( 12824684 )
2003
26
Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. ( 12042582 )
2002
27
Successful treatment of herpangina with allopurinol mouthwashes. ( 8523995 )
1995
28
Herpangina surveillance in Japan, 1982-1989. A report of the national epidemiological surveillance of infectious agents in Japan. ( 1652037 )
1991
29
Case #12. Herpangina. ( 1819839 )
1991
30
Outbreak of herpangina associated with Coxsackievirus B3 infection. ( 2549494 )
1989
31
Herpangina in an anesthesiologist. ( 7189386 )
1980
32
Neonatal 'herpangina'. ( 221634 )
1979
33
Neonatal herpangina caused by Coxsackie A-5 virus. ( 690774 )
1978
34
Herpangina and pleurodynia associated with Herpes simplex virus. ( 5560625 )
1971
35
Herpangina: the etiologic spectrum. ( 5834068 )
1965
36
ISOLATION OF COXSACKIE A6 VIRUS FROM THE SERUM OF A CASE OF HERPANGINA IN VELLORE. ( 14264195 )
1964
37
Herpangina: ulcerative pharyngitis with the isolation of Coxsackie virus. ( 13565002 )
1958
38
A new syndrome of parotitis with herpangina caused by the Coxsackie virus. ( 13437259 )
1957
39
Coxsackie virus diseases; a review with some new clinical observations concerning herpangina. ( 14373118 )
1955
40
Herpangina and herpetic gingivostomatitis; clinical differentiation. ( 14371260 )
1955
41
Clinical and laboratory differentiation between herpangina and infectious (herpetic) gingivostomatitis. ( 13185685 )
1954
42
Herpangina with isolation of the virus. ( 13099585 )
1953
43
HERPANGINA. ( 13011960 )
1953
44
[Herpangina and stomatitis herpetica; epidemiological observations in Stuttgart]. ( 13060087 )
1953
45
Herpangina; a clinical and virological study. ( 13081040 )
1953
46
Certain physical properties of a herpangina strain and a pleurodynia strain of Coxsackie virus. ( 13064194 )
1953
47
Herpangina; clinical and laboratory aspects of an outbreak caused by group A Coxsackie viruses. ( 13037430 )
1953
48
Studies in man of neutralizing antibodies against group A Coxsackie (herpangina) viruses; prevalence of antibodies in a community in 1949 and 1950. ( 12996492 )
1952
49
The importance of Coxsackie viruses in human disease, particularly herpangina and epidemic pleurodynia. ( 14947935 )
1952
50
Evaluation of serological methods for demonstrating antibody responses to group A Coxsackie (herpangina) viruses. ( 14938555 )
1952

Variations for Herpangina

Expression for Herpangina

Search GEO for disease gene expression data for Herpangina.

Pathways for Herpangina

Pathways related to Herpangina according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.26 CA4 CA5A CA6

GO Terms for Herpangina

Biological processes related to Herpangina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicarbonate transport GO:0015701 9.13 CA4 CA5A CA6
2 one-carbon metabolic process GO:0006730 8.8 CA4 CA5A CA6

Molecular functions related to Herpangina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.33 CA4 CA5A CA6
2 lyase activity GO:0016829 9.13 CA4 CA5A CA6
3 carbonate dehydratase activity GO:0004089 8.8 CA4 CA5A CA6

Sources for Herpangina

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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