MCID: HRP001
MIFTS: 39

Herpangina

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Herpangina

Summaries for Herpangina

Disease Ontology : 12 A viral infectious disease that results in infection located in mouth, has material basis in Human coxsackievirus A16, has material basis in Human enterovirus 71, has material basis in group B coxsackievirus, or has material basis in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

MalaCards based summary : Herpangina, also known as vesicular pharyngitis, is related to influenza and mouth disease. An important gene associated with Herpangina is AMHR2 (Anti-Mullerian Hormone Receptor Type 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Influenza A. The drugs Ribavirin and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include tongue, cervix and salivary gland.

Wikipedia : 76 Herpangina, also called mouth blisters, is a painful mouth infection caused by coxsackieviruses. ... more...

Related Diseases for Herpangina

Diseases related to Herpangina via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 influenza 29.8 IFNA1 IFNB1 TLR7
2 mouth disease 10.7
3 hand, foot and mouth disease 10.6
4 type 1 diabetes mellitus 18 10.2 TNFRSF10A TNFRSF25
5 chickenpox 10.2 AMHR2 DPT
6 superficial keratitis 10.2 IFNA2 TNFRSF25
7 type 1 diabetes mellitus 5 10.2 TNFRSF10A TNFRSF25
8 septicemic plague 10.2 IFNB1 TLR7
9 punctate epithelial keratoconjunctivitis 10.1 IFNA2 TNFRSF25
10 epidemic pleurodynia 10.1
11 neuroretinitis 10.1 IFNB1 TNFRSF10A
12 lymphomatoid granulomatosis 10.1 IFNA1 IFNA2
13 squamous papillomatosis 10.1 IFNA1 IFNA2
14 cryoglobulinemia, familial mixed 10.1 IFNA1 IFNA2
15 salivary gland disease 10.1 AMHR2 DPT MFSD6
16 oral erosive lichen 10.1 IFNA1 IFNB1
17 autoimmune disease of endocrine system 10.1 TNFRSF10A TNFRSF25
18 discoid lupus erythematosus 10.1 IFNA1 IFNA2
19 immune system disease 10.1 IFNB1 TNFRSF10A TNFRSF25
20 murray valley encephalitis 10.1 IFNA1 IFNB1
21 autoimmune disease of gastrointestinal tract 10.0 TNFRSF10A TNFRSF25
22 microphthalmia with limb anomalies 10.0 IFNA1 IFNB1
23 cervical adenosarcoma 10.0 GP5 GP6
24 inverted follicular keratosis 10.0 GP5 GP6
25 newcastle disease 10.0 IFNA1 IFNB1
26 parotitis 10.0
27 pharyngitis 10.0
28 herpes simplex 10.0
29 encephalitis 10.0
30 stomatitis 10.0
31 cervical carcinosarcoma 10.0 GP5 GP6
32 cervix uteri carcinoma in situ 10.0 GP5 GP6
33 uterus carcinoma in situ 10.0 GP5 GP6
34 kaposi sarcoma 9.9 IFNA1 IFNA2 IFNB1
35 anogenital venereal wart 9.9 GP6 IFNB1 MID2 TLR7
36 chilblain lupus 1 9.9 IFNB1 TNFRSF25
37 vulvar disease 9.9 GP5 LINC01191
38 hepatitis c 9.9 IFNA1 IFNA2 IFNB1
39 viral infectious disease 9.9 IFNA1 IFNA2 IFNB1 TLR7
40 vaginal disease 9.8 GP5 LINC01191 TLR7
41 penile disease 9.8 GP6 IFNA2 LINC01191 MID2 TLR7
42 anus disease 9.7 GP5 LINC01191 MID2 TLR7
43 rectal disease 9.7 GP5 LINC01191 MID2 TLR7
44 focal epithelial hyperplasia 9.6 GP5 GP6 IFNA2 IFNB1 TNFRSF10A

Graphical network of the top 20 diseases related to Herpangina:



Diseases related to Herpangina

Symptoms & Phenotypes for Herpangina

Drugs & Therapeutics for Herpangina

Drugs for Herpangina (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 4 36791-04-5 37542
2 Immunologic Factors Phase 4,Phase 3
3 Interferon-alpha Phase 4
4 Antiviral Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Antimetabolites Phase 4
7 interferons Phase 4
8 Vaccines Phase 3
9
Sucralfate Approved Phase 2 54182-58-0 0
10
Acetaminophen Approved Phase 2 103-90-2 1983
11
Ibuprofen Approved Phase 2 15687-27-1 3672
12 Anti-Inflammatory Agents, Non-Steroidal Phase 2
13 Anti-Ulcer Agents Phase 2
14 Antacids Phase 2
15 Antirheumatic Agents Phase 2
16 Analgesics, Non-Narcotic Phase 2
17 Pharmaceutical Solutions Phase 2
18 Gastrointestinal Agents Phase 2
19 Analgesics Phase 2
20 Antipyretics Phase 2
21 Cyclooxygenase Inhibitors Phase 2
22 Peripheral Nervous System Agents Phase 2
23 Anti-Inflammatory Agents Phase 2
24 Grape Approved Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Recombinant Human Interferon α-2b Spray on Herpangina Recruiting NCT03266601 Phase 4 Recombinant Human Interferon α-2b Spray;Ribavirin
2 A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months Completed NCT01508247 Phase 3
3 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Enrolling by invitation NCT03241030 Phase 2 Sucralfate;Acetaminophen;Ibuprofen
4 Do Traditional or Flavored Tongue Depressors Make for Easier Posterior Oropharynx Exams in Pediatric Patients Completed NCT03095183 Not Applicable
5 Neurodevelopment Outcomes Following Severe Hand Foot and Mouth Disease in Vietnam Completed NCT02066714

Search NIH Clinical Center for Herpangina

Cochrane evidence based reviews: herpangina

Genetic Tests for Herpangina

Anatomical Context for Herpangina

MalaCards organs/tissues related to Herpangina:

41
Tongue, Cervix, Salivary Gland, Uterus

Publications for Herpangina

Articles related to Herpangina:

(show top 50) (show all 64)
# Title Authors Year
1
Hand, foot and mouth disease and herpangina caused by enterovirus A71 infections: a review of enterovirus A71 molecular epidemiology, pathogenesis, and current vaccine development. ( 30427405 )
2018
2
Factors associated with severe neurologic complications in patients with either hand-foot-mouth disease or herpangina: A nationwide observational study in South Korea, 2009-2014. ( 30096160 )
2018
3
Nationwide Survey of Pediatric Inpatients With Hand, Foot, and Mouth Disease, Herpangina, and Associated Complications During an Epidemic Period in Japan: Estimated Number of Hospitalized Patients and Factors Associated With Severe Cases. ( 30416163 )
2018
4
High prevalence of coxsackievirus A2 in children with herpangina in Thailand in 2015. ( 28466062 )
2017
5
Epidemiological and Etiological Characteristics of Herpangina and Hand Foot Mouth Diseases in Jiangsu, China, 2013-2014. ( 27768527 )
2016
6
Diagnostic uncertainty of herpangina and hand-foot-and-mouth disease and its impact on national enterovirus syndromic monitoring. ( 26593706 )
2016
7
Large outbreak of herpangina in children caused by enterovirus in summer of 2015 in Hangzhou, China. ( 27752104 )
2016
8
Enterovirus-related diarrhoea in Guangdong, China: clinical features and implications in hand, foot and mouth disease and herpangina. ( 26983856 )
2016
9
Molecular epidemiology of the enteroviruses associated with hand, foot and mouth disease/herpangina in Dongguan, China, 2015. ( 27654666 )
2016
10
An outbreak of Kingella kingae infections associated with hand, foot and mouth disease/herpangina virus outbreak in Marseille, France, 2013. ( 25742075 )
2015
11
PREVALENCE OF HUMAN ENTEROVIRUS AMONG PATIENTS WITH HAND, FOOT, AND MOUTH DISEASE AND HERPANGINA IN THAILAND, 2013. ( 26867359 )
2015
12
Genomic characteristics of coxsackievirus A8 strains associated with hand, foot, and mouth disease and herpangina. ( 26483280 )
2015
13
Prevalence and characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenza like illness in Thailand, 2012. ( 24887237 )
2014
14
Neurological Images and the Predictors for Neurological Sequelae of Epidemic Herpangina/Hand-Foot-Mouth Disease with Encephalomyelitis. ( 24258524 )
2013
15
Outbreak of herpangina in the Brazilian Amazon in 2009 caused by Enterovirus B. ( 24197788 )
2013
16
Enteroviruses isolated from herpangina and hand-foot-and-mouth disease in Korean children. ( 22985487 )
2012
17
Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study. ( 22404077 )
2012
18
Risk factors for hand, foot, and mouth disease and herpangina and the preventive effect of hand-washing. ( 21422083 )
2011
19
Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. ( 22239028 )
2011
20
Increased risk of adverse pregnancy outcomes among women affected by herpangina. ( 20417474 )
2010
21
Prevalence of enterovirus from patients with herpangina and hand, foot and mouth disease in Nagano Prefecture, Japan, 2007. ( 18503184 )
2008
22
Enterovirus detection status of patients with herpangina and hand, foot and mouth disease in epidemic season 2007, Kanagawa Prefecture, Japan. ( 18362414 )
2008
23
Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005. ( 17671037 )
2007
24
Differences in replication capacity between enterovirus 71 isolates obtained from patients with encephalitis and those obtained from patients with herpangina in Taiwan. ( 17133556 )
2007
25
Enterovirus detection status from patients with herpangina and hand, foot and mouth disease in Kanagawa Prefecture, Japan. ( 17314432 )
2007
26
Prevalence of coxsackievirus A5, A6, and A10 in patients with herpangina in Aichi Prefecture, 2005. ( 16377876 )
2005
27
Seasonal models of herpangina and hand-foot-mouth disease to simulate annual fluctuations in urban warming in Tokyo. ( 12824684 )
2003
28
Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease/herpangina in children during an epidemic in Taiwan. ( 12042582 )
2002
29
Successful treatment of herpangina with allopurinol mouthwashes. ( 8523995 )
1995
30
Herpangina surveillance in Japan, 1982-1989. A report of the national epidemiological surveillance of infectious agents in Japan. ( 1652037 )
1991
31
Case #12. Herpangina. ( 1819839 )
1991
32
Outbreak of herpangina associated with Coxsackievirus B3 infection. ( 2549494 )
1989
33
Herpangina in an anesthesiologist. ( 7189386 )
1980
34
Neonatal 'herpangina'. ( 221634 )
1979
35
Neonatal herpangina caused by Coxsackie A-5 virus. ( 690774 )
1978
36
Herpangina and pleurodynia associated with Herpes simplex virus. ( 5560625 )
1971
37
Herpangina: the etiologic spectrum. ( 5834068 )
1965
38
ISOLATION OF COXSACKIE A6 VIRUS FROM THE SERUM OF A CASE OF HERPANGINA IN VELLORE. ( 14264195 )
1964
39
Vesicular pharyngitis associated with Coxsackie virus group B, type 5. ( 13916016 )
1961
40
Herpangina: ulcerative pharyngitis with the isolation of Coxsackie virus. ( 13565002 )
1958
41
A new syndrome of parotitis with herpangina caused by the Coxsackie virus. ( 13437259 )
1957
42
Clinical findings in an epidemic of herpangina with myalgic, neurological and gastro-enteritic features. ( 13446834 )
1957
43
Coxsackie virus diseases; a review with some new clinical observations concerning herpangina. ( 14373118 )
1955
44
Herpangina and herpetic gingivostomatitis; clinical differentiation. ( 14371260 )
1955
45
Clinical and laboratory differentiation between herpangina and infectious (herpetic) gingivostomatitis. ( 13185685 )
1954
46
Herpangina with isolation of the virus. ( 13099585 )
1953
47
HERPANGINA. ( 13011960 )
1953
48
[Herpangina and stomatitis herpetica; epidemiological observations in Stuttgart]. ( 13060087 )
1953
49
Herpangina; a clinical and virological study. ( 13081040 )
1953
50
Certain physical properties of a herpangina strain and a pleurodynia strain of Coxsackie virus. ( 13064194 )
1953

Variations for Herpangina

Expression for Herpangina

Search GEO for disease gene expression data for Herpangina.

Pathways for Herpangina

Pathways related to Herpangina according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 GP5 GP6 IFNA1 IFNA2 IFNB1 TNFRSF10A
2
Show member pathways
12.24 IFNA1 IFNA2 IFNB1 TLR7 TNFRSF10A
3
Show member pathways
12.1 IFNA1 IFNA2 IFNB1 TNFRSF10A
4
Show member pathways
12.01 IFNA1 IFNA2 IFNB1
5 11.99 IFNA1 IFNA2 IFNB1
6 11.92 IFNA1 IFNA2 IFNB1
7 11.85 IFNA1 IFNA2 IFNB1
8 11.75 IFNA1 IFNA2 IFNB1
9 11.55 IFNA1 IFNA2 IFNB1
10
Show member pathways
11.49 IFNA1 IFNA2 IFNB1 TNFRSF10A
11 11.3 IFNA2 IFNB1 TLR7
12 11.1 IFNA2 IFNB1
13 10.56 IFNA1 IFNA2 IFNB1 TNFRSF10A
14 10.48 GP5 GP6

GO Terms for Herpangina

Biological processes related to Herpangina according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.83 IFNA2 IFNB1 TNFRSF10A TNFRSF25
2 defense response to virus GO:0051607 9.73 IFNA1 IFNA2 IFNB1 TLR7
3 defense response GO:0006952 9.72 IFNA1 IFNA2 IFNB1
4 B cell differentiation GO:0030183 9.69 IFNA1 IFNA2 IFNB1
5 type I interferon signaling pathway GO:0060337 9.67 IFNA1 IFNA2 IFNB1
6 humoral immune response GO:0006959 9.63 IFNA1 IFNA2 IFNB1
7 negative regulation of viral entry into host cell GO:0046597 9.54 IFNA2 MID2
8 B cell proliferation GO:0042100 9.54 IFNA1 IFNA2 IFNB1
9 response to exogenous dsRNA GO:0043330 9.5 IFNA1 IFNA2 IFNB1
10 negative regulation of T cell differentiation GO:0045581 9.48 IFNA2 IFNB1
11 T cell activation involved in immune response GO:0002286 9.43 IFNA1 IFNA2 IFNB1
12 negative regulation of T-helper 2 cell cytokine production GO:2000552 9.4 IFNA2 IFNB1
13 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.33 IFNA1 IFNA2 IFNB1
14 natural killer cell activation involved in immune response GO:0002323 9.13 IFNA1 IFNA2 IFNB1
15 blood coagulation GO:0007596 9.02 GP5 GP6 IFNA1 IFNA2 IFNB1

Molecular functions related to Herpangina according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 IFNA1 IFNA2 IFNB1
2 cytokine receptor binding GO:0005126 9.13 IFNA1 IFNA2 IFNB1
3 type I interferon receptor binding GO:0005132 8.8 IFNA1 IFNA2 IFNB1

Sources for Herpangina

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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