Herpes Simplex disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HRP006 MIFTS: 71	Herpes Simplex Categories: Infectious diseases, Rare diseases
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Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Name: Herpes Simplex ¹² ⁵⁶ ⁴⁴ ⁴⁵ ¹⁵

Herpesvirus Hominis Disease ¹²

Herpes Simplex Infections ⁷⁴

Herpes Simplex Disease ⁷⁷

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Certain infectious and parasitic diseases

Viral infections characterized by skin and mucous membrane lesions

Herpesviral [herpes simplex] infections

Herpesviral infection, unspecified

External Ids:

Disease Ontology ¹² DOID:8566

ICD9CM ³⁶ 054

MeSH ⁴⁵ D006561

SNOMED-CT ⁶⁹ 88594005

ICD10 ³⁴ B00 B00.9

UMLS ⁷⁴ C0019348

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Summaries for Herpes Simplex

MedlinePlus : ⁴⁴ Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and acute retinal necrosis syndrome, and has symptoms including fever, pruritus and snoring. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Docosanol and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and eye, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : ¹² A viral infectious disease that results in_formation_of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : ⁷⁷ Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human... more...

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Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 682)

#	Related Disease	Score	Top Affiliating Genes
1	herpes simplex encephalitis	34.6	IRF3 TBK1 TICAM1 TLR3 TRAF3 UNC93B1
2	acute retinal necrosis syndrome	32.7	NECTIN1 TNFRSF14
3	encephalitis	32.2	IRF3 TICAM1 TLR3 TRAF3 UNC93B1
4	rabies	30.6	IRF3 PML TLR3
5	influenza	30.6	EIF2AK2 IRF3 PML TLR3
6	noonan syndrome 3	30.0	IRF3 TBK1 TLR3
7	herpes simplex virus keratitis	12.7
8	congenital herpes simplex virus infection	12.6
9	congenital herpes simplex	12.4
10	eczema herpeticum	12.4
11	encephalopathy, acute, infection-induced 1	12.3
12	genital herpes	12.2
13	encephalopathy, acute, infection-induced 2	12.2
14	encephalopathy, acute, infection-induced 8	12.0
15	neonatal herpes	11.8
16	encephalopathy, acute, infection-induced 5	11.7
17	herpetic whitlow	11.7
18	mollaret meningitis	11.7
19	encephalopathy, acute, infection-induced 6	11.6
20	encephalopathy, acute, infection-induced 7	11.6
21	erythema multiforme	11.6
22	cytomegalovirus infection	11.5
23	proctitis	11.5
24	viral pneumonia	11.5
25	aphthous stomatitis	11.5
26	cytomegalic inclusion disease	11.5
27	hyper-ige recurrent infection syndrome 2, autosomal recessive	11.2
28	caspase 8 deficiency	11.2
29	immunodeficiency 31a	11.2
30	salivary gland disease	11.2
31	pseudomembranous conjunctivitis	11.2
32	herpetic gastritis	11.2
33	congenital intrauterine infection-like syndrome	11.2
34	pudendal neuralgia	11.2
35	recessive dystrophic epidermolysis bullosa-generalized other	11.2
36	torch syndrome	11.2
37	neurological consequences of cytomegalovirus infection	11.2
38	keratitis, hereditary	10.7
39	chickenpox	10.7
40	hepatitis	10.7
41	meningitis	10.6
42	stromal keratitis	10.6
43	esophagitis	10.6
44	glioma	10.5
45	bell's palsy	10.5
46	acute liver failure	10.5
47	leukemia	10.5
48	alzheimer disease	10.5
49	myelitis	10.5
50	meningoencephalitis	10.5

Graphical network of the top 20 diseases related to Herpes Simplex:

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Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:

fever, pruritus, snoring, halitosis, pelvic pain

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	9.55	EIF2AK2 TBK1
2	Decreased viability	GR00221-A-2	9.55	EIF2AK2 TBK1
3	Decreased viability	GR00221-A-3	9.55	EIF2AK2
4	Decreased viability	GR00221-A-4	9.55	EIF2AK2
5	Decreased viability	GR00301-A	9.55	EIF2AK2 TBK1
6	Decreased viability	GR00342-S-1	9.55	EIF2AK2 TBK1 TLR3
7	Decreased viability	GR00342-S-2	9.55	EIF2AK2 TBK1 TLR3
8	Decreased viability	GR00402-S-2	9.55	EIF2AK2 TBK1 TLR3

MGI Mouse Phenotypes related to Herpes Simplex:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.17	CGAS EIF2AK2 PILRA PML POU2F1 TAP1
2	homeostasis/metabolism	MP:0005376	10.03	CGAS IRF3 NECTIN1 PILRA PML TBK1
3	immune system	MP:0005387	10	CGAS EIF2AK2 IRF3 PILRA PML TAP1
4	liver/biliary system	MP:0005370	9.5	HCFC1 PILRA POU2F1 TBK1 TICAM1 TRAF3
5	mortality/aging	MP:0010768	9.5	CGAS EIF2AK2 HCFC1 NECTIN1 PILRA PML

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Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 304)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Docosanol

Approved, Investigational

Phase 4

30303-65-2, 661-19-8

12620

Acyclovir

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

59277-89-3

2022

Ganciclovir

Approved, Investigational

Phase 4,Phase 2,Phase 1,Not Applicable

82410-32-0

3454

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3

302-25-0

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3

50-24-8

5755

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3

2921-57-5

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3

83-43-2

6741

Metronidazole

Approved

Phase 4

443-48-1

4173

Bimatoprost

Approved, Investigational

Phase 4

155206-00-1

5311027

Dinoprost

Approved, Investigational

Phase 4

551-11-1

5283078

Dinoprost tromethamine

Approved, Vet_approved

Phase 4

38562-01-5

5282415

Mycophenolic acid

Approved

Phase 4,Phase 3

24280-93-1

446541

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Early Phase 1

22916-47-8

4189

Nevirapine

Approved

Phase 4

129618-40-2

4463

Ritonavir

Approved, Investigational

Phase 4,Phase 3

155213-67-5

392622

Emtricitabine

Approved, Investigational

Phase 4,Not Applicable

143491-57-0

60877

Penciclovir

Approved

Phase 4,Phase 3

39809-25-1

4725

Famciclovir

Approved, Investigational

Phase 4,Phase 3,Phase 2

104227-87-4

3324

Difluprednate

Approved

Phase 4

23674-86-4

443936

Melatonin

Approved, Nutraceutical, Vet_approved

Phase 4

73-31-4

896

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3

2920-86-7

Tenofovir

Experimental, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

147127-20-6

464205

Antiviral Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Ganciclovir triphosphate

Phase 4,Phase 2,Phase 1,Not Applicable

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Antiparasitic Agents

Phase 4,Phase 2

Antiprotozoal Agents

Phase 4,Phase 2

valacyclovir

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Ophthalmic Solutions

Phase 4

Prednisolone acetate

Phase 4,Phase 3

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 1,Not Applicable

Autonomic Agents

Phase 4,Phase 3,Phase 1

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Methylprednisolone Acetate

Phase 4,Phase 3

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Neuroprotective Agents

Phase 4,Phase 3

Dermatologic Agents

Phase 4,Phase 2,Not Applicable,Early Phase 1

Protective Agents

Phase 4,Phase 3,Phase 2

glucocorticoids

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antirheumatic Agents

Phase 4,Phase 1

Gastrointestinal Agents

Phase 4,Phase 3,Phase 1

Central Nervous System Depressants

Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Anti-HIV Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Denatonium

Phase 4

Interventional clinical trials:

(show top 50) (show all 314)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Topical Antiviral Agents for Labial Cold Sores (Herpes Labialis)	Unknown status	NCT00467662	Phase 4	Acyclovir 5%;Docosanol 10%
2	PTH - Preemptive Treatment for Herpesviridae	Unknown status	NCT02152358	Phase 4	Aciclovir;Ganciclovir;Placebo
3	Effect of HSV-2 Suppressive Therapy on Sexual Behavior	Unknown status	NCT00495716	Phase 4	acyclovir;acyclovir
4	Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding	Completed	NCT01448616	Phase 4	TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
5	Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study	Completed	NCT00464542	Phase 4	Metronidazole
6	A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies.	Completed	NCT00158860	Phase 4	Valaciclovir;Placebo
7	Palatability Testing of a New Paediatric Formulation of Valacyclovir	Completed	NCT01682109	Phase 4	Valacyclovir
8	Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV	Completed	NCT00527618	Phase 4	valacyclovir;acyclovir
9	Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia	Completed	NCT01794897	Phase 4	Experimental: Valacyclovir treatment;Placebo comparator
10	A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons	Completed	NCT00161434	Phase 4	valacyclovir;placebo
11	Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2	Completed	NCT01346475	Phase 4	valacyclovir;Valacyclovir
12	A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation	Completed	NCT00723229	Phase 4	acyclovir
13	Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2	Completed	NCT00362297	Phase 4	acyclovir;valacyclovir
14	VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies.	Completed	NCT00116844	Phase 4	Valaciclovir;Placebo
15	Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons	Completed	NCT01026454	Phase 4	acyclovir;valacyclovir
16	VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2	Completed	NCT00306293	Phase 4	valacyclovir
17	A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand	Completed	NCT00362596	Phase 4	acyclovir
18	Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)	Completed	NCT02059655	Phase 4	Bimatoprost;Eye drop solution
19	A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation	Completed	NCT00048165	Phase 4	Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
20	Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT)	Completed	NCT00552240	Phase 4	tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
21	A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers	Completed	NCT00820534	Phase 4	Penciclovir;Placebo
22	Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients	Completed	NCT00477334	Phase 4	Famciclovir;Placebo
23	A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis	Completed	NCT00248144	Phase 4	Famciclovir
24	RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir	Completed	NCT00219310	Phase 4	Famciclovir
25	A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding	Completed	NCT00129818	Phase 4	Famciclovir
26	Melatonin Effects on Genital Herpes in Brazilian Women	Recruiting	NCT03831165	Phase 4	Acyclovir 400 MG
27	A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis	Not yet recruiting	NCT03626376	Phase 4	oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
28	The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis	Terminated	NCT02045082	Phase 4
29	A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons	Terminated	NCT00079911	Phase 4	valacyclovir hydrochloride
30	A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients	Unknown status	NCT00005663	Phase 3	Valacyclovir hydrochloride
31	Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Central Nervous System	Unknown status	NCT00006132	Phase 3	acyclovir
32	Herpetic Eye Disease Study (HEDS) I	Unknown status	NCT00000138	Phase 3	Prednisolone Phosphate;Acyclovir
33	Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community	Unknown status	NCT00124878	Phase 3
34	NB-001 Treatment of Recurrent Herpes Labialis	Unknown status	NCT01695187	Phase 3	NB-001 (0.3%);Placebo
35	Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease	Completed	NCT00699764	Phase 3
36	Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects	Completed	NCT00698568	Phase 3
37	Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old	Completed	NCT00224484	Phase 3
38	Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth	Completed	NCT00031447	Phase 3	Acyclovir;Placebo
39	Open-label Study of ASP2151 in Herpes Simplex Patients	Completed	NCT02209324	Phase 3	ASP2151
40	Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine	Completed	NCT00224471	Phase 3
41	Phase III Study of ASP2151 in Herpes Simplex Patients	Completed	NCT01959295	Phase 3	ASP2151;ASP2151 placebo
42	Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients	Completed	NCT01602562	Phase 3	VACV tablets (Adults or pediatrics) or granules (pediatrics)
43	Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia	Completed	NCT00855309	Phase 3	acyclovir sodium
44	Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates	Completed	NCT00031460	Phase 3	Acyclovir;Placebo
45	Valaciclovir to Prevent Transmission of Herpes Simplex Virus	Completed	NCT00001649	Phase 3	Valaciclovir
46	Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection	Completed	NCT00098059	Phase 3	Famciclovir
47	Zinc for the Treatment of Herpes Simplex Labialis (HSL)	Completed	NCT00809809	Phase 3	Zicam (Ionic zinc);placebo
48	Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir	Completed	NCT00031486	Phase 3	Valacyclovir;Placebo
49	HerpeVac Trial for Young Women	Completed	NCT00057330	Phase 3
50	Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth	Completed	NCT00006135	Phase 3	acyclovir

Search NIH Clinical Center for Herpes Simplex

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

acyclovir

acyclovir sodium

benzocaine

benzocaine pwdr

famciclovir

herpes simplex virus nucleoside analog dna polymerase inhibitor [epc]

herpes simplex virus pyrophosphate analog dna polymerase inhibitor [epc]

methylene blue

valacyclovir

valacyclovir hydrochloride

Cochrane evidence based reviews: herpes simplex

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Genetic Tests for Herpes Simplex

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Anatomical Context for Herpes Simplex

MalaCards organs/tissues related to Herpes Simplex:

⁴²

Skin, T Cells, Eye, Brain, Testes, Liver, Breast

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

²⁰

H, Face, Mouth, Genitalia

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Publications for Herpes Simplex

Articles related to Herpes Simplex:

(show top 50) (show all 6218)

#	Title	Authors	Year
1	Inhibition of colorectal cancer liver metastasis in BALB/c mice following intratumoral injection of oncolytic herpes simplex virus type 2 for the induction of specific antitumor immunity. ( 30655834 )	Zhang W...Liu S	2019
2	Cerebral Venous Thrombosis as Rare Presentation of Herpes Simplex Virus Encephalitis. ( 30800483 )	Leite J...Duque V	2019
3	Continuous Electroencephalogram as a Biomarker of Disease Progression and Severity in Herpes Simplex Virus-1 Encephalitis. ( 30873853 )	Baten A...Gutierrez C	2019
4	An Adult Case of Herpes Simplex Virus-Associated Granulomatous Encephalitis. ( 30626834 )	Iwai Y...Kuwabara S	2019
5	Acyclovir Unresponsive Herpes Simplex Encephalitis in a child successfully treated with the addition of Foscarnet: Case report. ( 30652455 )	Gayretli Aydin ZG...Kaman A	2019
6	Recurrent Herpes Simplex Virus Encephalitis After Epilepsy Surgery. ( 30665474 )	Arnold A...Federico P	2019
7	Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis. ( 30683700 )	Mancini M...Vidal SM	2019
8	Anti-NMDAR Encephalitis in Association with Herpes Simplex Virus and Viral and Bacterial Zoonoses. ( 30692769 )	Yan Hung SK...Viswanathan S	2019
9	Mouse model of anti-NMDA receptor post-herpes simplex encephalitis. ( 30697582 )	Linnoila J...Chen J	2019
10	The recruitment of peripheral blood leukocytes to the brain is delayed in susceptible BALB/c compared to resistant C57BL/6 mice during herpes simplex virus encephalitis. ( 30758810 )	Canivet C...Boivin G	2019
11	Suspected Herpes Simplex Encephalitis with Low Copy Number DNA. ( 30607771 )	Kato K...Kawashima H	2019
12	Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report. ( 30653172 )	Shin J...Rho CR	2019
13	Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement. ( 30654754 )	Kurosawa S...Setoguchi K	2019
14	Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease. ( 30725296 )	Hoversten P...Katzka DA	2019
15	Herpes Simplex-Like Fixed Drug Eruption Induced by Fluconazole Without Cross-reactivity to Itraconazole. ( 30829805 )	Schneller-Pavelescu L...Silvestre-Salvador JF	2019
16	Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. ( 30279232 )	Passaro C...Nakashima H	2019
17	Targeting STT3A-oligosaccharyltransferase with NGI-1 causes herpes simplex virus 1 dysfunction. ( 30811219 )	Lu H...Lehrman MA	2019
18	Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population. ( 30814317 )	Akhtar LN...Szpara ML	2019
19	Co-infection of Herpes Simplex Virus Type 2 and HIV Infections among Pregnant Women in Ibadan, Nigeria. ( 30814831 )	Anaedobe CG...Ajani TA	2019
20	Prevalence of herpes simplex virus-1 in hospitalized adult patients with clinical diagnosis of meningoencephalitis using real-time polymerase chain reaction: A single-center, cross-sectional study. ( 30815020 )	Shirani K...Yazdani M	2019
21	Contribution of Human Herpesvirus 8 and Herpes Simplex Type 2 to Progression of Carotid Intima-Media Thickness in People Living With HIV. ( 30815506 )	Lid?n F...Masi? M	2019
22	Therapeutic Challenges and Prognosis of Descemet's Membrane Endothelial Keratoplasty in Herpes Simplex Eye Disease. ( 30817327 )	Abdelmassih Y...Gabison EE	2019
23	Bilateral Herpes Simplex Virus-related Peripheral Ulcerative Keratitis Leading to Corneal Perforation in a Patient with Primary Herpes Simplex Virus Infection. ( 30820293 )	Chranioti A...Ziakas N	2019
24	Herpes Simplex Infection During Pregnancy, Results of a Tertiary Referral Center in Turkey. ( 30831604 )	Sert UY...Engin-Ustun Y	2019
25	The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection. ( 30837340 )	Cabrera JR...Leib DA	2019
26	The Combination of Dimorphandra gardneriana Galactomannan and Mangiferin Inhibits Herpes Simplex and Poliovirus. ( 30848197 )	Rechenchoski DZ...Linhares REC	2019
27	Molecular analyses and phylogeny of the herpes simplex virus 2 US9 and glycoproteins gE/gI obtained from infected subjects during the Herpevac Trial for Women. ( 30849089 )	Rowe KL...Morrison LA	2019
28	Bilateral herpes simplex keratitis: lactation a trigger for recurrence! ( 30852508 )	Agarwal R...Sharma N	2019
29	Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: model-based predictions. ( 30853029 )	Ayoub HH...Abu-Raddad LJ	2019
30	A comparison of the Quidel Solana HSV 1 + 2/VZV Assay, the Focus Diagnostics Simplexa HSV 1 & 2 Direct Assay and the Luminex Aries HSV 1&2 Assay for detection of herpes simplex virus 1 and 2 from swab specimens. ( 30856386 )	Slinger R...Desjardins M	2019
31	Differences in the likelihood of acyclovir resistance-associated mutations in the thymidine kinase genes of herpes simplex virus 1 and varicella-zoster virus. ( 30858222 )	Fujii H...Saijo M	2019
32	Herpes Simplex Virus Infections in Solid Organ Transplantation - Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. ( 30859647 )	Lee DH...AST Infectious Diseases Community of Practice	2019
33	Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders. ( 30863282 )	Duarte LF...Gonz?lez PA	2019
34	Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation. ( 30863402 )	Guan X...Hu Q	2019
35	Innate immune response in astrocytes infected with herpes simplex virus 1. ( 30868265 )	Bansode YD...Saha B	2019
36	Hypertrophic Herpes Simplex With Subsequent Development of Plasma Cell Vulvitis: A Potential Diagnostic Pitfall. ( 30870250 )	Elghobashy M...El-Ghobashy A	2019
37	Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice. ( 30870531 )	De Chiara G...Palamara AT	2019
38	Successful Management of Herpes Simplex Keratitis With Oral Valganciclovir in Patients Unresponsive or Allergic to Conventional Antiviral Therapy. ( 30882539 )	Koseoglu ND...Hamrah P	2019
39	Regulation of T-type Ca2+ channel expression by interleukin-6 in sensory-like ND7/23 cells post herpes simplex virus (HSV-1) infection. ( 30888683 )	Zhang Q...Martin-Caraballo M	2019
40	Preparation of a monoPEGylated derivative of cyanovirin-N and its virucidal effect on acyclovir-resistant strains of herpes simplex virus type 1. ( 30903291 )	Lei Y...Xiong S	2019
41	Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014. ( 30911082 )	Donda K...Dapaah-Siakwan F	2019
42	Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol. ( 30915606 )	Liu S...Liang X	2019
43	Herpes Simplex Virus 1 ICP22 Suppresses CD80 Expression by Murine Dendritic Cells. ( 30404803 )	Matundan H...Ghiasi H	2019
44	Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2. ( 30412859 )	Bourne N...Milligan GN	2019
45	Myelitis with Hypoglycorrhachia due to Herpes Simplex Virus 2 in an Immunocompetent Man. ( 30458898 )	Tomkinson C...Perera K	2019
46	The lack of association between herpes simplex virus 1 or Toxoplasma gondii infection and cognitive decline in the general population: An 11-year follow-up study. ( 30465879 )	Torniainen-Holm M...Yolken RH	2019
47	FDG-PET/CT findings, the vital clue to rare diagnosis of herpes simplex virus lymphadenitis simulating Richter transformation. ( 30471841 )	Douglas AP...Prince HM	2019
48	Stereotactic Placement of Intratumoral Catheters for Continuous Infusion Delivery of Herpes Simplex Virus -1 G207 in Pediatric Malignant Supratentorial Brain Tumors. ( 30481622 )	Bernstock JD...Johnston JM	2019
49	Unique Type I Interferon, Expansion/Survival Cytokines, and JAK/STAT Gene Signatures of Multifunctional Herpes Simplex Virus-Specific Effector Memory CD8+ TEM Cells Are Associated with Asymptomatic Herpes in Humans. ( 30487281 )	Vahed H...BenMohamed L	2019
50	Missing Cases of Herpes Simplex Virus (HSV) Infection of the Central Nervous System When the Reller Criteria Are Applied for HSV PCR Testing: a Multicenter Study. ( 30487303 )	Albert E...Navarro D	2019

Sources

Genes for Herpes Simplex

Genes related to Herpes Simplex (0 elite genes):

(show all 37)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NECTIN1	Nectin Cell Adhesion Molecule 1	Protein Coding	85.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Gene name Summaries Proteins Pathways & Interactions Functions (show sections)	9861033 12915538 12885915 (more) 15731277 10482562 11836420 18502984 11544254 20455098 20089288 12915568 19129446 17005657 14963155 15972328 11531408 11483743 11437670 15534229 11069980 19521665 18005714 10627537 15273289 18803666
2	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	72.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Summaries Proteins Pathways & Interactions Functions (show sections)	11119586 9657005 19915044 (more) 11511354 18005714 12915568 12915538 11164894 19426226 12368332 12466117 18502984
3	HCFC1	Host Cell Factor C1	Protein Coding	71.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Summaries Proteins Pathways & Interactions Functions (show sections)	12456665 16042417 12271126 (more) 15190068 12670868 1684335 10637318 17698583 16282471 11711630 9223485 16633736 12743030 9334261 20126307 19016376 18520591 12244100 15705566 10871379 10629049 10196288 8392914 10398682 10984507 9123865 10958670 14532282 8454622 12235138
4	NECTIN2	Nectin Cell Adhesion Molecule 2	Protein Coding	59.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Summaries Proteins Functions (show sections)	12915538 11602758 12915581
5	TLR3	Toll Like Receptor 3	Protein Coding	59.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications Pathways & Interactions Variants (show sections)	19025601 16847112
6	UNC93B1	Unc-93 Homolog B1, TLR Signaling Regulator	Protein Coding	55.58	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
7	PML	Promyelocytic Leukemia	Protein Coding	53.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)	19279115 10574707 10233977 (more) 9151854 12186918 12610143 9658103 11485412 11602710
8	TBK1	TANK Binding Kinase 1	Protein Coding	50.31	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Proteins Pathways & Interactions (show sections)
9	IRF3	Interferon Regulatory Factor 3	Protein Coding	46.48	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)	12917470 17215277 16603509
10	POU2F1	POU Class 2 Homeobox 1	Protein Coding	46.16	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)	1684335 1358755 7568211 (more) 7891704 16282471 1406672 8284200 10398682 12271126 7642649 8441632 1645782 9315674
11	TMEM173	Transmembrane Protein 173	Protein Coding	44.58	GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
12	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	44.49	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)	16414988 9765401 9223497 (more) 9023344 11773369 9696792 12414939 17229694 11070019 15174900
13	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	44.09	GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
14	TAP2	Transporter 2, ATP Binding Cassette Subfamily B Member	Protein Coding	43.87	GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
15	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	42.25	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Summaries Functions (show sections)	9271389 10871379
16	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	41.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)
17	TICAM1	Toll Like Receptor Adaptor Molecule 1	Protein Coding	40.88	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)
18	IFI16	Interferon Gamma Inducible Protein 16	Protein Coding	39.44	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions localization (show sections)
19	PILRA	Paired Immunoglobin Like Type 2 Receptor Alpha	Protein Coding	34.49	GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
20	CGAS	Cyclic GMP-AMP Synthase	Protein Coding	29.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
21	DDX58	DExD/H-Box Helicase 58	Protein Coding	29.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
22	IFNA1	Interferon Alpha 1	Protein Coding	29.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Pathways & Interactions (show sections)	1719612 2153279 2158516 (more) 1379288 7852835 8863993 13130472 14969765 15320906 15622449 2172409 7697520 8724854 10652752 11836673 2168998 2264889 1719613 1331251 8031058 8380210 8181190 7855636 8578993 9139085 9637497 9707372 11482999 15727684 12687260 11544466 9335431 8887056 8830796 8709261 1666118 1695643 18653740 15163721 14963171 12893749 9802930 12209136 12738374 16000865 8103535 8027590 8091644 8711430 14742635 11927638 12224508 12845770 15753256 16603509 1883515 11488639 11689663 1655906
23	C3	Complement C3	Protein Coding	29.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
24	CD209	CD209 Molecule	Protein Coding	28.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions (show sections)
25	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	27.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
26	IFNB1	Interferon Beta 1	Protein Coding	27.51	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Pathways & Interactions (show sections)	11883188 16439992 16603509 (more) 1666118 15727684 9335431 14963171 1463323
27	ITGAV	Integrin Subunit Alpha V	Protein Coding	27.46	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions (show sections)
28	TLR9	Toll Like Receptor 9	Protein Coding	26.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19755019 17085599 19025601 (more) 18082566 11927638 16847112
29	POU2F2	POU Class 2 Homeobox 2	Protein Coding	25.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Pathways & Interactions (show sections)	8129727 8645173 7733899
30	HS3ST3B1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1	Protein Coding	25.87	GeneCards inferred via : Publications Summaries Functions (show sections)
31	ACKR1	Atypical Chemokine Receptor 1 (Duffy Blood Group)	Protein Coding	25.86	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8388365 12021353 7911177 (more) 12885915 14556904 9696802 9837796 12225814 15016549 18468509 18573279 7576569 9346834 11119586 10627537 7490454 7572464 1780614 1645898 15619895 17299053 15273289 17164784 16213178 12381352 9684378 9525660 1667262 16221064 16044540 7494331 9879759 7745699 18651758 18076965 11090178 19386594 18667634 16288376 15534229 18723002 18193057 12417744 11394975 10225292 10559300 15546385 12915581 12915568 12829851 12504254 12537725 8278393 20089288 8038227 1652468 1713774 2164044 19702506 16131544 12692272 11851316 8585768 8133093 18671825 15864815 14711338 10482637 11162814
32	HCFC2	Host Cell Factor C2	Protein Coding	25.75	GeneCards inferred via : Publications Summaries Pathways & Interactions (show sections)
33	CASP8	Caspase 8	Protein Coding	25.7	GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
34	GTF2B	General Transcription Factor IIB	Protein Coding	25.6	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Proteins (show sections)	14764096 7791769 8972203 (more) 11371188 8392607 10449590 15081896
35	SP100	SP100 Nuclear Antigen	Protein Coding	25.47	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Pathways & Interactions (show sections)	7626019 1310226 7828630 (more) 18160441 19279115
36	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	24.82	GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
37	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	24.57	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Pathways & Interactions (show sections)	9696792 9023344 11070019 (more) 15705855 9765401 11773369 9223497 10074192

Sources

Variations for Herpes Simplex

Sources

Expression for Herpes Simplex

Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: ³⁵

#	Gene	Description	Tissue	Up/Dn	Fold Change (log2)	P value
1	FCN1	ficolin (collagen/fibrinogen domain containing) 1	Skin	+	3.89	0.000
2	IRF1	interferon regulatory factor 1	Skin	+	3.58	0.000
3	STAT1	signal transducer and activator of transcription 1, 91kDa	Skin	+	3.53	0.000
4	RARRES3	retinoic acid receptor responder (tazarotene induced) 3	Skin	+	3.49	0.000
5	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	Skin	+	3.41	0.000
6	CCL19	chemokine (C-C motif) ligand 19	Skin	+	3.32	0.003
7	XAF1	XIAP associated factor 1	Skin	+	3.04	0.000

Search GEO for disease gene expression data for Herpes Simplex.

Sources

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	13.75	CGAS EIF2AK2 IFI16 IRF3 NECTIN2 PML
2	Toll-like Receptor Signaling Pathway ³⁸ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁸ Epstein-Barr virus infection ³⁸ Hepatitis B ³⁸ Hepatitis C ³⁸ NOD-like Receptor Signaling Pathways ⁶⁶ Regulation of toll-like receptor signaling pathway ¹	13.05	IFI16 IRF3 TBK1 TICAM1 TLR3 TMEM173
3	PI3K-Akt signaling pathway ³⁸ Show member pathways Human papillomavirus infection ³⁸	12.84	CREB3 EIF2AK2 IRF3 TBK1 TICAM1 TLR3
4	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁷ Show member pathways Cytosolic DNA-sensing pathway ³⁸ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Negative regulators of RIG-I/MDA5 signaling ⁶⁷ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁷ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁸ TRAF3-dependent IRF activation pathway ⁶⁷ TRAF6 mediated IRF7 activation ⁶⁷ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁶	12.61	CGAS IRF3 TBK1 TICAM1 TLR3 TMEM173
5	4-1BB Pathway ⁶⁵ Show member pathways CD27 Pathway ⁶⁵ CD40 Signaling ⁶⁵ CMV and MAPK Pathways ⁶⁵ NF-KappaB Activation by EBV ⁶⁵ NF-kappaB Activation by Viruses ⁶⁵ PKR Pathway ⁶⁵ SUMO Pathway ⁶⁵ TNFR2 Pathway ⁶⁵	12.51	CREB3 EIF2AK2 PML TBK1 TRAF3
6	Human cytomegalovirus infection ³⁸ Show member pathways Human immunodeficiency virus 1 infection ³⁸ Kaposi sarcoma-associated herpesvirus infection ³⁸	12.49	CGAS CREB3 EIF2AK2 IRF3 TAP1 TAP2
7	TRAF Pathway ⁶⁵ Show member pathways 14-3-3 Induced Apoptosis ⁶⁵ TNF Superfamily Pathway ⁶⁵ Toll-Like Receptors Pathway ⁶⁵	12.44	CREB3 IRF3 TBK1 TICAM1 TLR3 TNFRSF14
8	Cytosolic sensors of pathogen-associated DNA ⁶⁷ Show member pathways DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁷ IkBA variant leads to EDA-ID ⁶⁷ IKBKB deficiency causes SCID ⁶⁷ IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) ⁶⁷ IRF3 mediated activation of type 1 IFN ⁶⁷ IRF3-mediated induction of type I IFN ⁶⁷ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁷ Regulation by TREX1 ⁶⁷ Regulation of innate immune responses to cytosolic DNA ⁶⁷ RIP-mediated NFkB activation via ZBP1 ⁶⁷ STAT6-mediated induction of chemokines ⁶⁷ STING mediated induction of host immune responses ⁶⁷ TAK1 activates NFkB by phosphorylation and activation of IKKs complex ⁶⁷ TRAF6 mediated NF-kB activation ⁶⁷ ZBP1(DAI) mediated induction of type I IFNs ⁶⁷	12.28	CGAS IFI16 IRF3 TBK1 TICAM1 TLR3
9	VEGF Pathway (Qiagen) ⁶⁵ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁵ Development VEGF-family signaling ²³ Neurophilin interactions with VEGF and VEGFR ⁶⁷ VEGF Pathway ⁶⁵	12.27	CREB3 IRF3 TBK1 TICAM1 TLR3
10	NF-kappaB Signaling ⁴	12.27	IFI16 IRF3 TAP1 TAP2 TBK1 TICAM1
11	Viral carcinogenesis ³⁸	12.13	CREB3 EIF2AK2 IRF3 TRAF3
12	Diseases associated with the TLR signaling cascade ⁶⁷ Show member pathways Diseases of Immune System ⁶⁷ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁷ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁷ IRAK4 deficiency (TLR2/4) ⁶⁷ IRAK4 deficiency (TLR5) ⁶⁷ MyD88 deficiency (TLR2/4) ⁶⁷ MyD88 deficiency (TLR5) ⁶⁷ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.11	IRF3 TBK1 TICAM1 TLR3 TRAF3
13	Influenza A ³⁸ Show member pathways Measles ³⁸	11.95	EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2 PILRA
14	IKK complex recruitment mediated by RIP1 ⁶⁷	10.93	TICAM1 TLR3
15	Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶² Show member pathways Inhibition of PKR ⁶⁷	10.9	EIF2AK2 IRF3

Sources

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum	GO:0005783	9.76	CREB3 PML POU2F1 TAP1 TAP2 TLR3
2	endoplasmic reticulum membrane	GO:0005789	9.5	CREB3 PML TAP1 TAP2 TLR3 TMEM173
3	apical junction complex	GO:0043296	9.37	NECTIN1 NECTIN2
4	cell-cell contact zone	GO:0044291	9.32	NECTIN1 NECTIN2
5	MHC class I peptide loading complex	GO:0042824	9.26	TAP1 TAP2
6	TAP complex	GO:0042825	8.62	TAP1 TAP2

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 33)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.88	IRF3 TBK1 TICAM1 TLR3
2	defense response to virus	GO:0051607	9.85	CGAS EIF2AK2 IFI16 IRF3 PML TBK1
3	response to virus	GO:0009615	9.82	EIF2AK2 TBK1 TLR3
4	positive regulation of type I interferon production	GO:0032481	9.8	CGAS IFI16 IRF3 TBK1 TICAM1 TLR3
5	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.79	TBK1 TICAM1 TLR3
6	TRIF-dependent toll-like receptor signaling pathway	GO:0035666	9.77	IRF3 TBK1 TICAM1 TLR3 TRAF3
7	immune system process	GO:0002376	9.77	CGAS EIF2AK2 IFI16 IRF3 PML TAP1
8	toll-like receptor signaling pathway	GO:0002224	9.74	TLR3 TRAF3 UNC93B1
9	response to exogenous dsRNA	GO:0043330	9.73	IRF3 TICAM1 TLR3
10	positive regulation of cytokine production	GO:0001819	9.72	EIF2AK2 IFI16 TLR3
11	positive regulation of interferon-beta production	GO:0032728	9.71	IRF3 TBK1 TLR3
12	activation of innate immune response	GO:0002218	9.71	CGAS IFI16 TBK1 TMEM173
13	cellular response to exogenous dsRNA	GO:0071360	9.67	CGAS TLR3 TMEM173
14	myeloid cell differentiation	GO:0030099	9.66	IFI16 PML
15	cellular response to interferon-beta	GO:0035458	9.65	TLR3 TMEM173
16	positive regulation of chemokine production	GO:0032722	9.65	EIF2AK2 TLR3
17	necroptotic process	GO:0070266	9.65	TICAM1 TLR3
18	regulation of type I interferon production	GO:0032479	9.65	IRF3 TBK1 TMEM173
19	positive regulation of interferon-alpha production	GO:0032727	9.64	IRF3 TBK1
20	MyD88-independent toll-like receptor signaling pathway	GO:0002756	9.63	TICAM1 TLR3
21	peptide transport	GO:0015833	9.63	TAP1 TAP2
22	toll-like receptor 3 signaling pathway	GO:0034138	9.63	TICAM1 TLR3 UNC93B1
23	positive regulation of chemokine biosynthetic process	GO:0045080	9.62	TICAM1 TLR3
24	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO:0019885	9.61	TAP1 TAP2
25	negative regulation of MyD88-independent toll-like receptor signaling pathway	GO:0034128	9.61	TICAM1 TLR3
26	positive regulation of interferon-beta biosynthetic process	GO:0045359	9.61	TBK1 TICAM1 TLR3
27	vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	GO:1990668	9.59	TAP1 TAP2
28	virion attachment to host cell	GO:0019062	9.58	NECTIN1 NECTIN2
29	cytosol to ER transport	GO:0046967	9.52	TAP1 TAP2
30	viral process	GO:0016032	9.44	CREB3 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2
31	positive regulation of transcription by RNA polymerase II	GO:0045944	10.11	CREB3 HCFC1 IFI16 IRF3 POU2F1 TBK1
32	apoptotic process	GO:0006915	10.08	IFI16 IRF3 PML TICAM1 TMEM173 TRAF3
33	innate immune response	GO:0045087	10.06	CGAS EIF2AK2 IFI16 IRF3 PML TBK1

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:0042803	9.91	IRF3 NECTIN1 NECTIN2 PML TAP1 TMEM173
2	ubiquitin protein ligase binding	GO:0031625	9.78	PML TMEM173 TNFRSF14 TRAF3
3	protein binding	GO:0005515	9.6	CGAS CREB3 EIF2AK2 HCFC1 IFI16 IRF3
4	virus receptor activity	GO:0001618	9.58	NECTIN1 NECTIN2 TNFRSF14
5	identical protein binding	GO:0042802	9.56	EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2 TBK1
6	MHC class I protein binding	GO:0042288	9.49	PILRA TAP1
7	MHC protein binding	GO:0042287	9.46	TAP1 TAP2
8	peptide transmembrane transporter activity	GO:1904680	9.37	TAP1 TAP2
9	TAP1 binding	GO:0046978	9.32	TAP1 TAP2
10	MHC class Ib protein binding	GO:0023029	9.26	TAP1 TAP2
11	peptide antigen-transporting ATPase activity	GO:0015433	9.16	TAP1 TAP2

Sources

Sources for Herpes Simplex

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Herpes Simplex

Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Classifications:

External Ids:

Summaries for Herpes Simplex

Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Herpes Simplex:

Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Herpes Simplex:

Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: herpes simplex

Genetic Tests for Herpes Simplex

Anatomical Context for Herpes Simplex

MalaCards organs/tissues related to Herpes Simplex:

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

Publications for Herpes Simplex

Articles related to Herpes Simplex:

Genes for Herpes Simplex

Genes related to Herpes Simplex (0 elite genes):

Variations for Herpes Simplex

Expression for Herpes Simplex

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

Sources for Herpes Simplex

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :