MCID: HRP006
MIFTS: 70

Herpes Simplex

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Name: Herpes Simplex 12 55 43 44 15
Herpesvirus Hominis Disease 12
Herpes Simplex Infections 73
Herpes Simplex Disease 76

Classifications:



External Ids:

Disease Ontology 12 DOID:8566
ICD10 33 B00 B00.9
ICD9CM 35 054
MeSH 44 D006561
SNOMED-CT 68 88594005
UMLS 73 C0019348

Summaries for Herpes Simplex

MedlinePlus : 43 Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and acute retinal necrosis syndrome, and has symptoms including fever, pruritus and snoring. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Acyclovir and Docosanol have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and t cells, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A viral infectious disease that results in_formation_of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : 76 Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and... more...

Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 593)
# Related Disease Score Top Affiliating Genes
1 herpes simplex encephalitis 34.5 IRF3 TBK1 TLR3 TRAF3 UNC93B1
2 acute retinal necrosis syndrome 32.5 NECTIN1 TNFRSF14
3 encephalitis 32.1 IRF3 TLR3 TRAF3 UNC93B1
4 viral infectious disease 31.2 EIF2AK2 IRF3 TBK1 TLR3 TLR9
5 rabies 30.3 IRF3 PML TLR3
6 influenza 29.9 EIF2AK2 IRF3 PML TLR3 TLR9
7 herpes simplex virus keratitis 12.6
8 congenital herpes simplex virus infection 12.6
9 congenital herpes simplex 12.4
10 eczema herpeticum 12.4
11 encephalopathy, acute, infection-induced 1 12.3
12 genital herpes 12.2
13 encephalopathy, acute, infection-induced 2 12.1
14 encephalopathy, acute, infection-induced 8 11.9
15 neonatal herpes 11.8
16 encephalopathy, acute, infection-induced 5 11.7
17 herpetic whitlow 11.6
18 mollaret meningitis 11.6
19 encephalopathy, acute, infection-induced 6 11.6
20 encephalopathy, acute, infection-induced 7 11.6
21 erythema multiforme 11.6
22 cytomegalovirus infection 11.5
23 proctitis 11.5
24 viral pneumonia 11.5
25 aphthous stomatitis 11.5
26 cytomegalic inclusion disease 11.5
27 hyper-ige recurrent infection syndrome, autosomal recessive 11.2
28 caspase 8 deficiency 11.2
29 immunodeficiency 31a 11.2
30 salivary gland disease 11.2
31 pseudomembranous conjunctivitis 11.2
32 herpetic gastritis 11.2
33 congenital intrauterine infection-like syndrome 11.2
34 pudendal neuralgia 11.2
35 recessive dystrophic epidermolysis bullosa-generalized other 11.2
36 torch syndrome 11.2
37 neurological consequences of cytomegalovirus infection 11.2
38 stromal keratitis 10.6
39 hepatitis 10.6
40 meningitis 10.6
41 keratitis, hereditary 10.5
42 bell's palsy 10.5
43 acute liver failure 10.5
44 pneumonia 10.4
45 chickenpox 10.4
46 facial paralysis 10.4
47 alzheimer disease 10.4
48 glioma 10.4
49 human immunodeficiency virus type 1 10.4
50 myelitis 10.4

Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to Herpes Simplex

Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:


fever, pruritus, snoring, pelvic pain, halitosis

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.36 EIF2AK2 TBK1
2 Decreased viability GR00221-A-2 10.36 EIF2AK2 TBK1
3 Decreased viability GR00221-A-3 10.36 EIF2AK2
4 Decreased viability GR00221-A-4 10.36 EIF2AK2
5 Decreased viability GR00301-A 10.36 EIF2AK2 TBK1
6 Decreased viability GR00342-S-1 10.36 EIF2AK2 TBK1 TLR3
7 Decreased viability GR00342-S-2 10.36 EIF2AK2 TBK1 TLR3
8 Decreased viability GR00402-S-2 10.36 EIF2AK2 TBK1 TLR3 CREB3 HCFC1 IFI16
9 no effect GR00402-S-1 9.62 CREB3 EIF2AK2 HCFC1 IFI16 IRF3 NECTIN1

MGI Mouse Phenotypes related to Herpes Simplex:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 EIF2AK2 PILRA PML POU2F1 TAP1 TAP2
2 immune system MP:0005387 9.77 EIF2AK2 IRF3 PILRA PML TAP1 TAP2
3 mortality/aging MP:0010768 9.47 EIF2AK2 HCFC1 NECTIN1 PILRA PML POU2F1

Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 295)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59277-89-3 2022
2
Docosanol Approved, Investigational Phase 4 30303-65-2, 661-19-8 12620
3
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 82410-32-0 3454
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
6
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
8
Metronidazole Approved Phase 4 443-48-1 4173
9
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
10
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
11
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
12
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Early Phase 1 22916-47-8 4189
14
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
15
Emtricitabine Approved, Investigational Phase 4,Not Applicable 143491-57-0 60877
16
Nevirapine Approved Phase 4 129618-40-2 4463
17
Penciclovir Approved Phase 4,Phase 3 39809-25-1 4725
18
Famciclovir Approved, Investigational Phase 4,Phase 3,Phase 2 104227-87-4 3324
19
Difluprednate Approved Phase 4 23674-86-4 443936
20
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
21
Tenofovir Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147127-20-6 464205
22 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Ganciclovir triphosphate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Antiparasitic Agents Phase 4,Phase 2
27 Antiprotozoal Agents Phase 4,Phase 2
28 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Ophthalmic Solutions Phase 4
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Protective Agents Phase 4,Phase 3,Phase 2
33 Autonomic Agents Phase 4,Phase 3,Phase 1
34 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Antirheumatic Agents Phase 4,Phase 1
36 Gastrointestinal Agents Phase 4,Phase 3,Phase 1
37 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Not Applicable
39 Dermatologic Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
40 Prednisolone acetate Phase 4,Phase 3
41 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Immunoglobulin G Phase 4,Phase 2,Phase 1
43 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Methylprednisolone acetate Phase 4,Phase 3
45 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Antibodies Phase 4,Phase 2,Phase 1,Not Applicable
48 Immunoglobulins Phase 4,Phase 2,Phase 1,Not Applicable
49 Neuroprotective Agents Phase 4,Phase 3
50 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 316)
# Name Status NCT ID Phase Drugs
1 Comparison of Topical Antiviral Agents for Labial Cold Sores (Herpes Labialis) Unknown status NCT00467662 Phase 4 Acyclovir 5%;Docosanol 10%
2 PTH - Preemptive Treatment for Herpesviridae Unknown status NCT02152358 Phase 4 Aciclovir;Ganciclovir;Placebo
3 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Unknown status NCT00495716 Phase 4 acyclovir;acyclovir
4 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4 TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
5 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
6 Palatability Testing of a New Paediatric Formulation of Valacyclovir Completed NCT01682109 Phase 4 Valacyclovir
7 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4 valaciclovir (VALTREX®)
8 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4 valacyclovir;acyclovir
9 Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia Completed NCT01794897 Phase 4 Experimental: Valacyclovir treatment;Placebo comparator
10 A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons Completed NCT00161434 Phase 4 valacyclovir;placebo
11 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
12 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4 acyclovir
13 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4 acyclovir;valacyclovir
14 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4 Valaciclovir;Placebo
15 Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons Completed NCT01026454 Phase 4 acyclovir;valacyclovir
16 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4 valacyclovir
17 A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand Completed NCT00362596 Phase 4 acyclovir
18 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
19 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
20 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
21 A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers Completed NCT00820534 Phase 4 Penciclovir;Placebo
22 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4 Famciclovir;Placebo
23 A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis Completed NCT00248144 Phase 4 Famciclovir
24 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4 Famciclovir
25 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4 Famciclovir
26 A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
27 The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis Terminated NCT02045082 Phase 4
28 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4 valacyclovir hydrochloride
29 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
30 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Central Nervous System Unknown status NCT00006132 Phase 3 acyclovir
31 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
32 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
33 NB-001 Treatment of Recurrent Herpes Labialis Unknown status NCT01695187 Phase 3 NB-001 (0.3%);Placebo
34 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
35 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
36 Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old Completed NCT00224484 Phase 3
37 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
38 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3 ASP2151
39 Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine Completed NCT00224471 Phase 3
40 Phase III Study of ASP2151 in Herpes Simplex Patients Completed NCT01959295 Phase 3 ASP2151;ASP2151 placebo
41 Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients Completed NCT01602562 Phase 3 VACV tablets (Adults or pediatrics) or granules (pediatrics)
42 Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia Completed NCT00855309 Phase 3 acyclovir sodium
43 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
44 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3 Valaciclovir
45 Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection Completed NCT00098059 Phase 3 Famciclovir
46 Zinc for the Treatment of Herpes Simplex Labialis (HSL) Completed NCT00809809 Phase 3 Zicam (Ionic zinc);placebo
47 Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir Completed NCT00031486 Phase 3 Valacyclovir;Placebo
48 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3
49 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth Completed NCT00006135 Phase 3 acyclovir
50 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3 acyclovir

Search NIH Clinical Center for Herpes Simplex

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: herpes simplex

Genetic Tests for Herpes Simplex

Anatomical Context for Herpes Simplex

MalaCards organs/tissues related to Herpes Simplex:

41
Skin, Brain, T Cells, Eye, Testes, Liver, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

19
H, Face, Mouth, Genitalia

Publications for Herpes Simplex

Articles related to Herpes Simplex:

(show top 50) (show all 4595)
# Title Authors Year
1
Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2. ( 30412859 )
2019
2
Corrigendum: Inhibitory effect of Spirogyra spp. algal extracts against herpes simplex virus type 1 and 2 infection. ( 30556242 )
2019
3
Corrigendum to "Antibody-based immunotherapy of acyclovir resistant ocular herpes simplex virus infection" [Virology 512 (2017) 194-200]. ( 30290967 )
2019
4
Herpes simplex virus type-1 infection affects the expression of extracellular matrix components in human nucleus pulposus cells. ( 30339788 )
2019
5
Severe acyclovir-resistant herpes simplex virus 1 infection following cord blood transplantation. ( 29923124 )
2018
6
Descemet membrane endothelial keratoplasty for corneal decompensation caused by herpes simplex virus endotheliitis. ( 29502597 )
2018
7
Infectivity and growth kinetics of Herpes Simplex Virus type-2 in MOLT4 CCR5+ and CEM CCR5+ T cell lines. ( 29944889 )
2018
8
Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus-infected pregnant women: Results of a pilot study. ( 29905034 )
2018
9
A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient. ( 29446473 )
2018
10
Herpes Simplex Virus 1 Dramatically Alters Loading and Positioning of RNA Polymerase II on Host Genes Early in Infection. ( 29437966 )
2018
11
Pneumomediastinum and Pneumothorax Associated with Herpes Simplex Virus (HSV) Pneumonia. ( 29379004 )
2018
12
Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences. ( 29928582 )
2018
13
The apical region of the herpes simplex virus major capsid protein promotes capsid maturation. ( 29976665 )
2018
14
Extracellular vesicles released by herpes simplex virus 1 infected cells block virus replication in recipient cells in a STING-dependent manner. ( 29976662 )
2018
15
Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )
2018
16
Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity. ( 29976672 )
2018
17
Why do herpes simplex encephalitis and semantic dementia show a different pattern of semantic impairment in spite of their main common involvement within the anterior temporal lobes? ( 29573378 )
2018
18
Neonatal herpes simplex virus infections. ( 29544668 )
2018
19
Autoimmune Encephalitis Following Herpes Simplex Virus Encephalitis in an Infant. ( 29629704 )
2018
20
Clinical significance of IgM and IgA class anti-NMDAR antibodies in herpes simplex encephalitis. ( 29698873 )
2018
21
Proteomic Analysis of Secretomes of Oncolytic Herpes Simplex Virus-Infected Squamous Cell Carcinoma Cells. ( 29360750 )
2018
22
Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time. ( 29920588 )
2018
23
Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern? ( 29356762 )
2018
24
Corneal perforation after noncontact tonometry in patients with active recurrent herpes simplex keratitis: case report. ( 29417444 )
2018
25
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. ( 29113740 )
2018
26
Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis. ( 29749113 )
2018
27
Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma. ( 29796364 )
2018
28
A Novel System for Constructing a Recombinant Highly-Attenuated Vaccinia Virus Strain (LC16m8) Expressing Foreign Genes and Its Application for the Generation of LC16m8-Based Vaccines against Herpes Simplex Virus 2. ( 29709968 )
2018
29
Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. ( 29370719 )
2018
30
A case of herpes simplex virus pneumonia detected by sputum cytodiagnosis. ( 29375858 )
2018
31
QuickStats: Age-Adjusted* Trends in the Prevalence of Herpes Simplex Virus Type 1 (HSV-1) and Herpes Simplex Virus Type 2 (HSV-2) Among Adolescents and Adults Aged 14-49 Years - United States, 1999-2000 Through 2015-2016. ( 29447144 )
2018
32
Prevention and management of genital herpes simplex infection during pregnancy and delivery: Guidelines from the French College of Gynaecologists and Obstetricians (CNGOF). ( 29571124 )
2018
33
A Rare Case of Concurrent Herpes Simplex Encephalitis and Glioblastoma Multiforme. ( 29492128 )
2018
34
Deep RNA Sequencing Reveals a Repertoire of Human Fibroblast Circular RNAs Associated with Cellular Responses to Herpes Simplex Virus 1 Infection. ( 29972822 )
2018
35
Semantic language deficit developing following herpes simplex encephalitis: reorganization "cannibalising" language centers? ( 29350572 )
2018
36
ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. ( 29371118 )
2018
37
Disseminated herpes simplex virus: a case of eczema herpeticum causing viral encephalitis. ( 29741524 )
2018
38
Analysis of Select Herpes Simplex Virus 1 (HSV-1) Proteins for Restriction of Human Immunodeficiency Virus Type 1 (HIV-1): HSV-1 gM Protein Potently Restricts HIV-1 by Preventing Intracellular Transport and Processing of Env gp160. ( 29093081 )
2018
39
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. ( 29256984 )
2018
40
Disseminated herpes simplex virus and varicella zoster virus co-infection in an immunocompetent patient. ( 29451195 )
2018
41
Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains. ( 29427675 )
2018
42
CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection. ( 29437926 )
2018
43
Acute Disseminated Encephalomyelitis After Herpes Simplex Virus Meningoencephalitis in Adult. ( 29581077 )
2018
44
Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion. ( 29046455 )
2018
45
Herpes simplex encephalitis relapse associated with positive N-methyl-D-aspartate receptor antibodies. ( 29450730 )
2018
46
Fulminant Herpes Simplex Virus Type I Encephalitis Despite Maximal Medical Therapy. ( 29900087 )
2018
47
A case report of myocarditis combined with hepatitis caused by herpes simplex virus. ( 29970006 )
2018
48
The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication. ( 29263259 )
2018
49
Prevalence of Herpes Simplex Virus Type 1 and Type 2 in Persons Aged 14-49: United States, 2015-2016. ( 29442994 )
2018
50
Cellular Anti-Silencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate-Early Gene Expression. ( 29950408 )
2018

Variations for Herpes Simplex

Expression for Herpes Simplex

LifeMap Discovery
Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 FCN1 ficolin (collagen/fibrinogen domain containing) 1 Skin + 3.89 0.000
2 IRF1 interferon regulatory factor 1 Skin + 3.58 0.000
3 STAT1 signal transducer and activator of transcription 1, 91kDa Skin + 3.53 0.000
4 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 Skin + 3.49 0.000
5 SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 Skin + 3.41 0.000
6 CCL19 chemokine (C-C motif) ligand 19 Skin + 3.32 0.003
7 XAF1 XIAP associated factor 1 Skin + 3.04 0.000
Search GEO for disease gene expression data for Herpes Simplex.

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 EIF2AK2 IFI16 IRF3 NECTIN2 PML POU2F1
2
Show member pathways
13.2 EIF2AK2 IRF3 PML POU2F1 TNFRSF14 TNFSF14
3
Show member pathways
12.89 CREB3 EIF2AK2 IRF3 TAP1 TAP2 TBK1
4
Show member pathways
12.86 CREB3 EIF2AK2 IRF3 TBK1 TBP TLR3
5
Show member pathways
12.85 IFI16 IRF3 TBK1 TLR3 TLR9 TRAF3
6
Show member pathways
12.57 CREB3 EIF2AK2 PML TBK1 TBP TRAF3
7
Show member pathways
12.29 CREB3 IRF3 TBK1 TLR3 TLR9 TNFRSF14
8
Show member pathways
12.28 CREB3 IRF3 TBK1 TLR3 TLR9
9
Show member pathways
12.27 IFI16 IRF3 TBK1 TLR3
10
Show member pathways
12.21 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2 PILRA
11 12.16 CREB3 EIF2AK2 IRF3 TBP TRAF3
12
Show member pathways
12.11 IRF3 TBK1 TLR3 TLR9 TRAF3
13 12.1 EIF2AK2 IRF3 TAP1 TAP2 TBK1 TRAF3
14 12.07 IFI16 IRF3 TAP1 TAP2 TBK1 TLR3
15 11.88 EIF2AK2 IRF3 TBK1 TLR3 TRAF3
16 11.48 NECTIN2 TNFRSF14 TNFSF14
17
Show member pathways
10.93 EIF2AK2 IRF3

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.83 PML TLR3 TLR9 TRAF3 UNC93B1
2 endoplasmic reticulum GO:0005783 9.76 CREB3 PML POU2F1 TAP1 TAP2 TLR3
3 endoplasmic reticulum membrane GO:0005789 9.5 CREB3 PML TAP1 TAP2 TLR3 TLR9
4 apical junction complex GO:0043296 9.48 NECTIN1 NECTIN2
5 cell-cell contact zone GO:0044291 9.46 NECTIN1 NECTIN2
6 endolysosome membrane GO:0036020 9.37 TLR3 TLR9
7 early phagosome GO:0032009 9.32 TLR9 UNC93B1
8 MHC class I peptide loading complex GO:0042824 9.26 TAP1 TAP2
9 TAP complex GO:0042825 8.62 TAP1 TAP2
10 membrane GO:0016020 10.28 CREB3 EIF2AK2 HCFC1 IFI16 NECTIN1 NECTIN2

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.91 EIF2AK2 IFI16 IRF3 PML TBK1 TLR3
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.88 IRF3 TBK1 TLR3 TLR9
3 response to virus GO:0009615 9.83 EIF2AK2 TBK1 TLR3
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.79 TNFRSF14 TNFSF14 TRAF3
5 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.78 TBK1 TLR3 TLR9
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 EIF2AK2 TLR3 TLR9 TNFSF14
7 defense response to virus GO:0051607 9.76 EIF2AK2 IFI16 IRF3 PML TBK1 TLR3
8 toll-like receptor signaling pathway GO:0002224 9.73 TLR3 TLR9 TRAF3 UNC93B1
9 positive regulation of cytokine production GO:0001819 9.71 EIF2AK2 IFI16 TLR3
10 positive regulation of type I interferon production GO:0032481 9.71 IFI16 IRF3 TBK1 TLR3
11 immune system process GO:0002376 9.7 EIF2AK2 IFI16 IRF3 PML TAP1 TAP2
12 positive regulation of chemokine production GO:0032722 9.67 EIF2AK2 TLR3 TLR9
13 positive regulation of interferon-beta production GO:0032728 9.67 IRF3 TBK1 TLR3 TLR9
14 activation of innate immune response GO:0002218 9.65 IFI16 TBK1
15 toll-like receptor 9 signaling pathway GO:0034162 9.65 TLR9 UNC93B1
16 positive regulation of interferon-alpha production GO:0032727 9.64 IRF3 TBK1
17 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.64 TLR3 TLR9
18 I-kappaB phosphorylation GO:0007252 9.63 TLR3 TLR9
19 regulation of type I interferon production GO:0032479 9.63 IRF3 TBK1
20 positive regulation of interferon-beta biosynthetic process GO:0045359 9.63 TBK1 TLR3 TLR9
21 toll-like receptor 3 signaling pathway GO:0034138 9.62 TLR3 UNC93B1
22 peptide transport GO:0015833 9.62 TAP1 TAP2
23 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.62 IRF3 TBK1 TLR3 TRAF3
24 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.6 TAP1 TAP2
25 cellular response to dsRNA GO:0071359 9.59 IRF3 TLR3
26 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.58 TAP1 TAP2
27 virion attachment to host cell GO:0019062 9.57 NECTIN1 NECTIN2
28 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.56 TLR3 TLR9
29 positive regulation of toll-like receptor signaling pathway GO:0034123 9.55 TLR3 TLR9
30 cytosol to ER transport GO:0046967 9.52 TAP1 TAP2
31 viral process GO:0016032 9.44 CREB3 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2
32 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 CREB3 HCFC1 IFI16 IRF3 POU2F1 TBK1

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.93 IRF3 NECTIN1 NECTIN2 PML TAP1 TLR9
2 identical protein binding GO:0042802 9.87 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2 TBK1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.8 CREB3 IFI16 IRF3 POU2F1 TBP
4 virus receptor activity GO:0001618 9.61 NECTIN1 NECTIN2 TNFRSF14
5 protein binding GO:0005515 9.58 CREB3 EIF2AK2 HCFC1 IFI16 IRF3 NECTIN1
6 MHC class I protein binding GO:0042288 9.49 PILRA TAP1
7 MHC protein binding GO:0042287 9.48 TAP1 TAP2
8 peptide transmembrane transporter activity GO:1904680 9.37 TAP1 TAP2
9 TAP1 binding GO:0046978 9.26 TAP1 TAP2
10 MHC class Ib protein binding GO:0023029 9.16 TAP1 TAP2
11 peptide antigen-transporting ATPase activity GO:0015433 8.96 TAP1 TAP2

Sources for Herpes Simplex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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