MCID: HRP006
MIFTS: 71

Herpes Simplex

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Name: Herpes Simplex 12 56 44 45 15
Herpesvirus Hominis Disease 12
Herpes Simplex Infections 74
Herpes Simplex Disease 77

Classifications:



External Ids:

Disease Ontology 12 DOID:8566
ICD9CM 36 054
MeSH 45 D006561
SNOMED-CT 69 88594005
ICD10 34 B00 B00.9
UMLS 74 C0019348

Summaries for Herpes Simplex

MedlinePlus : 44 Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and acute retinal necrosis syndrome, and has symptoms including fever, pruritus and snoring. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Docosanol and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and eye, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A viral infectious disease that results in_formation_of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : 77 Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human... more...

Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 682)
# Related Disease Score Top Affiliating Genes
1 herpes simplex encephalitis 34.6 IRF3 TBK1 TICAM1 TLR3 TRAF3 UNC93B1
2 acute retinal necrosis syndrome 32.7 NECTIN1 TNFRSF14
3 encephalitis 32.2 IRF3 TICAM1 TLR3 TRAF3 UNC93B1
4 rabies 30.6 IRF3 PML TLR3
5 influenza 30.6 EIF2AK2 IRF3 PML TLR3
6 noonan syndrome 3 30.0 IRF3 TBK1 TLR3
7 herpes simplex virus keratitis 12.7
8 congenital herpes simplex virus infection 12.6
9 congenital herpes simplex 12.4
10 eczema herpeticum 12.4
11 encephalopathy, acute, infection-induced 1 12.3
12 genital herpes 12.2
13 encephalopathy, acute, infection-induced 2 12.2
14 encephalopathy, acute, infection-induced 8 12.0
15 neonatal herpes 11.8
16 encephalopathy, acute, infection-induced 5 11.7
17 herpetic whitlow 11.7
18 mollaret meningitis 11.7
19 encephalopathy, acute, infection-induced 6 11.6
20 encephalopathy, acute, infection-induced 7 11.6
21 erythema multiforme 11.6
22 cytomegalovirus infection 11.5
23 proctitis 11.5
24 viral pneumonia 11.5
25 aphthous stomatitis 11.5
26 cytomegalic inclusion disease 11.5
27 hyper-ige recurrent infection syndrome 2, autosomal recessive 11.2
28 caspase 8 deficiency 11.2
29 immunodeficiency 31a 11.2
30 salivary gland disease 11.2
31 pseudomembranous conjunctivitis 11.2
32 herpetic gastritis 11.2
33 congenital intrauterine infection-like syndrome 11.2
34 pudendal neuralgia 11.2
35 recessive dystrophic epidermolysis bullosa-generalized other 11.2
36 torch syndrome 11.2
37 neurological consequences of cytomegalovirus infection 11.2
38 keratitis, hereditary 10.7
39 chickenpox 10.7
40 hepatitis 10.7
41 meningitis 10.6
42 stromal keratitis 10.6
43 esophagitis 10.6
44 glioma 10.5
45 bell's palsy 10.5
46 acute liver failure 10.5
47 leukemia 10.5
48 alzheimer disease 10.5
49 myelitis 10.5
50 meningoencephalitis 10.5

Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to Herpes Simplex

Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:


fever, pruritus, snoring, halitosis, pelvic pain

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.55 EIF2AK2 TBK1
2 Decreased viability GR00221-A-2 9.55 EIF2AK2 TBK1
3 Decreased viability GR00221-A-3 9.55 EIF2AK2
4 Decreased viability GR00221-A-4 9.55 EIF2AK2
5 Decreased viability GR00301-A 9.55 EIF2AK2 TBK1
6 Decreased viability GR00342-S-1 9.55 EIF2AK2 TBK1 TLR3
7 Decreased viability GR00342-S-2 9.55 EIF2AK2 TBK1 TLR3
8 Decreased viability GR00402-S-2 9.55 EIF2AK2 TBK1 TLR3

MGI Mouse Phenotypes related to Herpes Simplex:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 CGAS EIF2AK2 PILRA PML POU2F1 TAP1
2 homeostasis/metabolism MP:0005376 10.03 CGAS IRF3 NECTIN1 PILRA PML TBK1
3 immune system MP:0005387 10 CGAS EIF2AK2 IRF3 PILRA PML TAP1
4 liver/biliary system MP:0005370 9.5 HCFC1 PILRA POU2F1 TBK1 TICAM1 TRAF3
5 mortality/aging MP:0010768 9.5 CGAS EIF2AK2 HCFC1 NECTIN1 PILRA PML

Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 304)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Docosanol Approved, Investigational Phase 4 30303-65-2, 661-19-8 12620
2
Acyclovir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59277-89-3 2022
3
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 82410-32-0 3454
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
6
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
8
Metronidazole Approved Phase 4 443-48-1 4173
9
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
10
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
11
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
12
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Early Phase 1 22916-47-8 4189
14
Nevirapine Approved Phase 4 129618-40-2 4463
15
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
16
Emtricitabine Approved, Investigational Phase 4,Not Applicable 143491-57-0 60877
17
Penciclovir Approved Phase 4,Phase 3 39809-25-1 4725
18
Famciclovir Approved, Investigational Phase 4,Phase 3,Phase 2 104227-87-4 3324
19
Difluprednate Approved Phase 4 23674-86-4 443936
20
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
21
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
22
Tenofovir Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147127-20-6 464205
23 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Ganciclovir triphosphate Phase 4,Phase 2,Phase 1,Not Applicable
27 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Antiparasitic Agents Phase 4,Phase 2
29 Antiprotozoal Agents Phase 4,Phase 2
30 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Ophthalmic Solutions Phase 4
32 Prednisolone acetate Phase 4,Phase 3
33 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Not Applicable
35 Autonomic Agents Phase 4,Phase 3,Phase 1
36 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Methylprednisolone Acetate Phase 4,Phase 3
38 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Neuroprotective Agents Phase 4,Phase 3
42 Dermatologic Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
43 Protective Agents Phase 4,Phase 3,Phase 2
44 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Antirheumatic Agents Phase 4,Phase 1
47 Gastrointestinal Agents Phase 4,Phase 3,Phase 1
48 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
49 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Denatonium Phase 4

Interventional clinical trials:

(show top 50) (show all 314)
# Name Status NCT ID Phase Drugs
1 Comparison of Topical Antiviral Agents for Labial Cold Sores (Herpes Labialis) Unknown status NCT00467662 Phase 4 Acyclovir 5%;Docosanol 10%
2 PTH - Preemptive Treatment for Herpesviridae Unknown status NCT02152358 Phase 4 Aciclovir;Ganciclovir;Placebo
3 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Unknown status NCT00495716 Phase 4 acyclovir;acyclovir
4 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4 TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
5 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
6 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4 Valaciclovir;Placebo
7 Palatability Testing of a New Paediatric Formulation of Valacyclovir Completed NCT01682109 Phase 4 Valacyclovir
8 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4 valacyclovir;acyclovir
9 Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia Completed NCT01794897 Phase 4 Experimental: Valacyclovir treatment;Placebo comparator
10 A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons Completed NCT00161434 Phase 4 valacyclovir;placebo
11 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
12 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4 acyclovir
13 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4 acyclovir;valacyclovir
14 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4 Valaciclovir;Placebo
15 Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons Completed NCT01026454 Phase 4 acyclovir;valacyclovir
16 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4 valacyclovir
17 A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand Completed NCT00362596 Phase 4 acyclovir
18 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
19 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
20 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
21 A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers Completed NCT00820534 Phase 4 Penciclovir;Placebo
22 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4 Famciclovir;Placebo
23 A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis Completed NCT00248144 Phase 4 Famciclovir
24 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4 Famciclovir
25 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4 Famciclovir
26 Melatonin Effects on Genital Herpes in Brazilian Women Recruiting NCT03831165 Phase 4 Acyclovir 400 MG
27 A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
28 The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis Terminated NCT02045082 Phase 4
29 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4 valacyclovir hydrochloride
30 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
31 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Central Nervous System Unknown status NCT00006132 Phase 3 acyclovir
32 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
33 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
34 NB-001 Treatment of Recurrent Herpes Labialis Unknown status NCT01695187 Phase 3 NB-001 (0.3%);Placebo
35 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
36 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
37 Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old Completed NCT00224484 Phase 3
38 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
39 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3 ASP2151
40 Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine Completed NCT00224471 Phase 3
41 Phase III Study of ASP2151 in Herpes Simplex Patients Completed NCT01959295 Phase 3 ASP2151;ASP2151 placebo
42 Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients Completed NCT01602562 Phase 3 VACV tablets (Adults or pediatrics) or granules (pediatrics)
43 Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia Completed NCT00855309 Phase 3 acyclovir sodium
44 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
45 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3 Valaciclovir
46 Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection Completed NCT00098059 Phase 3 Famciclovir
47 Zinc for the Treatment of Herpes Simplex Labialis (HSL) Completed NCT00809809 Phase 3 Zicam (Ionic zinc);placebo
48 Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir Completed NCT00031486 Phase 3 Valacyclovir;Placebo
49 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3
50 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth Completed NCT00006135 Phase 3 acyclovir

Search NIH Clinical Center for Herpes Simplex

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: herpes simplex

Genetic Tests for Herpes Simplex

Anatomical Context for Herpes Simplex

MalaCards organs/tissues related to Herpes Simplex:

42
Skin, T Cells, Eye, Brain, Testes, Liver, Breast

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

20
H, Face, Mouth, Genitalia

Publications for Herpes Simplex

Articles related to Herpes Simplex:

(show top 50) (show all 6218)
# Title Authors Year
1
Inhibition of colorectal cancer liver metastasis in BALB/c mice following intratumoral injection of oncolytic herpes simplex virus type 2 for the induction of specific antitumor immunity. ( 30655834 )
2019
2
Cerebral Venous Thrombosis as Rare Presentation of Herpes Simplex Virus Encephalitis. ( 30800483 )
2019
3
Continuous Electroencephalogram as a Biomarker of Disease Progression and Severity in Herpes Simplex Virus-1 Encephalitis. ( 30873853 )
2019
4
An Adult Case of Herpes Simplex Virus-Associated Granulomatous Encephalitis. ( 30626834 )
2019
5
Acyclovir Unresponsive Herpes Simplex Encephalitis in a child successfully treated with the addition of Foscarnet: Case report. ( 30652455 )
2019
6
Recurrent Herpes Simplex Virus Encephalitis After Epilepsy Surgery. ( 30665474 )
2019
7
Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis. ( 30683700 )
2019
8
Anti-NMDAR Encephalitis in Association with Herpes Simplex Virus and Viral and Bacterial Zoonoses. ( 30692769 )
2019
9
Mouse model of anti-NMDA receptor post-herpes simplex encephalitis. ( 30697582 )
2019
10
The recruitment of peripheral blood leukocytes to the brain is delayed in susceptible BALB/c compared to resistant C57BL/6 mice during herpes simplex virus encephalitis. ( 30758810 )
2019
11
Suspected Herpes Simplex Encephalitis with Low Copy Number DNA. ( 30607771 )
2019
12
Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report. ( 30653172 )
2019
13
Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement. ( 30654754 )
2019
14
Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease. ( 30725296 )
2019
15
Herpes Simplex-Like Fixed Drug Eruption Induced by Fluconazole Without Cross-reactivity to Itraconazole. ( 30829805 )
2019
16
Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. ( 30279232 )
2019
17
Targeting STT3A-oligosaccharyltransferase with NGI-1 causes herpes simplex virus 1 dysfunction. ( 30811219 )
2019
18
Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population. ( 30814317 )
2019
19
Co-infection of Herpes Simplex Virus Type 2 and HIV Infections among Pregnant Women in Ibadan, Nigeria. ( 30814831 )
2019
20
Prevalence of herpes simplex virus-1 in hospitalized adult patients with clinical diagnosis of meningoencephalitis using real-time polymerase chain reaction: A single-center, cross-sectional study. ( 30815020 )
2019
21
Contribution of Human Herpesvirus 8 and Herpes Simplex Type 2 to Progression of Carotid Intima-Media Thickness in People Living With HIV. ( 30815506 )
2019
22
Therapeutic Challenges and Prognosis of Descemet's Membrane Endothelial Keratoplasty in Herpes Simplex Eye Disease. ( 30817327 )
2019
23
Bilateral Herpes Simplex Virus-related Peripheral Ulcerative Keratitis Leading to Corneal Perforation in a Patient with Primary Herpes Simplex Virus Infection. ( 30820293 )
2019
24
Herpes Simplex Infection During Pregnancy, Results of a Tertiary Referral Center in Turkey. ( 30831604 )
2019
25
The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection. ( 30837340 )
2019
26
The Combination of Dimorphandra gardneriana Galactomannan and Mangiferin Inhibits Herpes Simplex and Poliovirus. ( 30848197 )
2019
27
Molecular analyses and phylogeny of the herpes simplex virus 2 US9 and glycoproteins gE/gI obtained from infected subjects during the Herpevac Trial for Women. ( 30849089 )
2019
28
Bilateral herpes simplex keratitis: lactation a trigger for recurrence! ( 30852508 )
2019
29
Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: model-based predictions. ( 30853029 )
2019
30
A comparison of the Quidel Solana HSV 1 + 2/VZV Assay, the Focus Diagnostics Simplexa HSV 1 & 2 Direct Assay and the Luminex Aries HSV 1&2 Assay for detection of herpes simplex virus 1 and 2 from swab specimens. ( 30856386 )
2019
31
Differences in the likelihood of acyclovir resistance-associated mutations in the thymidine kinase genes of herpes simplex virus 1 and varicella-zoster virus. ( 30858222 )
2019
32
Herpes Simplex Virus Infections in Solid Organ Transplantation - Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. ( 30859647 )
2019
33
Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders. ( 30863282 )
2019
34
Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-β Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation. ( 30863402 )
2019
35
Innate immune response in astrocytes infected with herpes simplex virus 1. ( 30868265 )
2019
36
Hypertrophic Herpes Simplex With Subsequent Development of Plasma Cell Vulvitis: A Potential Diagnostic Pitfall. ( 30870250 )
2019
37
Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice. ( 30870531 )
2019
38
Successful Management of Herpes Simplex Keratitis With Oral Valganciclovir in Patients Unresponsive or Allergic to Conventional Antiviral Therapy. ( 30882539 )
2019
39
Regulation of T-type Ca2+ channel expression by interleukin-6 in sensory-like ND7/23 cells post herpes simplex virus (HSV-1) infection. ( 30888683 )
2019
40
Preparation of a monoPEGylated derivative of cyanovirin-N and its virucidal effect on acyclovir-resistant strains of herpes simplex virus type 1. ( 30903291 )
2019
41
Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014. ( 30911082 )
2019
42
Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol. ( 30915606 )
2019
43
Herpes Simplex Virus 1 ICP22 Suppresses CD80 Expression by Murine Dendritic Cells. ( 30404803 )
2019
44
Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2. ( 30412859 )
2019
45
Myelitis with Hypoglycorrhachia due to Herpes Simplex Virus 2 in an Immunocompetent Man. ( 30458898 )
2019
46
The lack of association between herpes simplex virus 1 or Toxoplasma gondii infection and cognitive decline in the general population: An 11-year follow-up study. ( 30465879 )
2019
47
FDG-PET/CT findings, the vital clue to rare diagnosis of herpes simplex virus lymphadenitis simulating Richter transformation. ( 30471841 )
2019
48
Stereotactic Placement of Intratumoral Catheters for Continuous Infusion Delivery of Herpes Simplex Virus -1 G207 in Pediatric Malignant Supratentorial Brain Tumors. ( 30481622 )
2019
49
Unique Type I Interferon, Expansion/Survival Cytokines, and JAK/STAT Gene Signatures of Multifunctional Herpes Simplex Virus-Specific Effector Memory CD8+ TEM Cells Are Associated with Asymptomatic Herpes in Humans. ( 30487281 )
2019
50
Missing Cases of Herpes Simplex Virus (HSV) Infection of the Central Nervous System When the Reller Criteria Are Applied for HSV PCR Testing: a Multicenter Study. ( 30487303 )
2019

Variations for Herpes Simplex

Expression for Herpes Simplex

LifeMap Discovery
Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 FCN1 ficolin (collagen/fibrinogen domain containing) 1 Skin + 3.89 0.000
2 IRF1 interferon regulatory factor 1 Skin + 3.58 0.000
3 STAT1 signal transducer and activator of transcription 1, 91kDa Skin + 3.53 0.000
4 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 Skin + 3.49 0.000
5 SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 Skin + 3.41 0.000
6 CCL19 chemokine (C-C motif) ligand 19 Skin + 3.32 0.003
7 XAF1 XIAP associated factor 1 Skin + 3.04 0.000
Search GEO for disease gene expression data for Herpes Simplex.

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 CGAS EIF2AK2 IFI16 IRF3 NECTIN2 PML
2
Show member pathways
13.05 IFI16 IRF3 TBK1 TICAM1 TLR3 TMEM173
3
Show member pathways
12.84 CREB3 EIF2AK2 IRF3 TBK1 TICAM1 TLR3
4
Show member pathways
12.61 CGAS IRF3 TBK1 TICAM1 TLR3 TMEM173
5
Show member pathways
12.51 CREB3 EIF2AK2 PML TBK1 TRAF3
6
Show member pathways
12.49 CGAS CREB3 EIF2AK2 IRF3 TAP1 TAP2
7
Show member pathways
12.44 CREB3 IRF3 TBK1 TICAM1 TLR3 TNFRSF14
8
Show member pathways
12.28 CGAS IFI16 IRF3 TBK1 TICAM1 TLR3
9
Show member pathways
12.27 CREB3 IRF3 TBK1 TICAM1 TLR3
10 12.27 IFI16 IRF3 TAP1 TAP2 TBK1 TICAM1
11 12.13 CREB3 EIF2AK2 IRF3 TRAF3
12
Show member pathways
12.11 IRF3 TBK1 TICAM1 TLR3 TRAF3
13
Show member pathways
11.95 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2 PILRA
14 10.93 TICAM1 TLR3
15
Show member pathways
10.9 EIF2AK2 IRF3

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.76 CREB3 PML POU2F1 TAP1 TAP2 TLR3
2 endoplasmic reticulum membrane GO:0005789 9.5 CREB3 PML TAP1 TAP2 TLR3 TMEM173
3 apical junction complex GO:0043296 9.37 NECTIN1 NECTIN2
4 cell-cell contact zone GO:0044291 9.32 NECTIN1 NECTIN2
5 MHC class I peptide loading complex GO:0042824 9.26 TAP1 TAP2
6 TAP complex GO:0042825 8.62 TAP1 TAP2

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.88 IRF3 TBK1 TICAM1 TLR3
2 defense response to virus GO:0051607 9.85 CGAS EIF2AK2 IFI16 IRF3 PML TBK1
3 response to virus GO:0009615 9.82 EIF2AK2 TBK1 TLR3
4 positive regulation of type I interferon production GO:0032481 9.8 CGAS IFI16 IRF3 TBK1 TICAM1 TLR3
5 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.79 TBK1 TICAM1 TLR3
6 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.77 IRF3 TBK1 TICAM1 TLR3 TRAF3
7 immune system process GO:0002376 9.77 CGAS EIF2AK2 IFI16 IRF3 PML TAP1
8 toll-like receptor signaling pathway GO:0002224 9.74 TLR3 TRAF3 UNC93B1
9 response to exogenous dsRNA GO:0043330 9.73 IRF3 TICAM1 TLR3
10 positive regulation of cytokine production GO:0001819 9.72 EIF2AK2 IFI16 TLR3
11 positive regulation of interferon-beta production GO:0032728 9.71 IRF3 TBK1 TLR3
12 activation of innate immune response GO:0002218 9.71 CGAS IFI16 TBK1 TMEM173
13 cellular response to exogenous dsRNA GO:0071360 9.67 CGAS TLR3 TMEM173
14 myeloid cell differentiation GO:0030099 9.66 IFI16 PML
15 cellular response to interferon-beta GO:0035458 9.65 TLR3 TMEM173
16 positive regulation of chemokine production GO:0032722 9.65 EIF2AK2 TLR3
17 necroptotic process GO:0070266 9.65 TICAM1 TLR3
18 regulation of type I interferon production GO:0032479 9.65 IRF3 TBK1 TMEM173
19 positive regulation of interferon-alpha production GO:0032727 9.64 IRF3 TBK1
20 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.63 TICAM1 TLR3
21 peptide transport GO:0015833 9.63 TAP1 TAP2
22 toll-like receptor 3 signaling pathway GO:0034138 9.63 TICAM1 TLR3 UNC93B1
23 positive regulation of chemokine biosynthetic process GO:0045080 9.62 TICAM1 TLR3
24 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.61 TAP1 TAP2
25 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.61 TICAM1 TLR3
26 positive regulation of interferon-beta biosynthetic process GO:0045359 9.61 TBK1 TICAM1 TLR3
27 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.59 TAP1 TAP2
28 virion attachment to host cell GO:0019062 9.58 NECTIN1 NECTIN2
29 cytosol to ER transport GO:0046967 9.52 TAP1 TAP2
30 viral process GO:0016032 9.44 CREB3 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2
31 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 CREB3 HCFC1 IFI16 IRF3 POU2F1 TBK1
32 apoptotic process GO:0006915 10.08 IFI16 IRF3 PML TICAM1 TMEM173 TRAF3
33 innate immune response GO:0045087 10.06 CGAS EIF2AK2 IFI16 IRF3 PML TBK1

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.91 IRF3 NECTIN1 NECTIN2 PML TAP1 TMEM173
2 ubiquitin protein ligase binding GO:0031625 9.78 PML TMEM173 TNFRSF14 TRAF3
3 protein binding GO:0005515 9.6 CGAS CREB3 EIF2AK2 HCFC1 IFI16 IRF3
4 virus receptor activity GO:0001618 9.58 NECTIN1 NECTIN2 TNFRSF14
5 identical protein binding GO:0042802 9.56 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2 TBK1
6 MHC class I protein binding GO:0042288 9.49 PILRA TAP1
7 MHC protein binding GO:0042287 9.46 TAP1 TAP2
8 peptide transmembrane transporter activity GO:1904680 9.37 TAP1 TAP2
9 TAP1 binding GO:0046978 9.32 TAP1 TAP2
10 MHC class Ib protein binding GO:0023029 9.26 TAP1 TAP2
11 peptide antigen-transporting ATPase activity GO:0015433 9.16 TAP1 TAP2

Sources for Herpes Simplex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....