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MCID: HRP006
MIFTS: 71

Herpes Simplex

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Herpes Simplex

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MalaCards integrated aliases for Herpes Simplex:

Name: Herpes Simplex 12 56 44 45 15
Herpesvirus Hominis Disease 12
Herpes Simplex Infections 74
Herpes Simplex Disease 77

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:8566
ICD9CM 36 054
MeSH 45 D006561
SNOMED-CT 69 88594005
ICD10 34 B00 B00.9
UMLS 74 C0019348
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Summaries for Herpes Simplex

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MedlinePlus : 44 Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and acute retinal necrosis syndrome, and has symptoms including fever, pruritus and snoring. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Docosanol and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and brain, and related phenotypes are no effect and Decreased viability

Disease Ontology : 12 A viral infectious disease that results in_formation_of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : 77 Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human... more...

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Related Diseases for Herpes Simplex

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Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 707)
# Related Disease Score Top Affiliating Genes
1 herpes simplex encephalitis 34.6 IRF3 TBK1 TICAM1 TLR3 TRAF3 UNC93B1
2 acute retinal necrosis syndrome 32.7 NECTIN1 TNFRSF14
3 encephalitis 32.1 DDX58 IRF3 TICAM1 TLR3 TRAF3 UNC93B1
4 rabies 30.6 IRF3 PML TLR3
5 influenza 30.5 DDX58 EIF2AK2 IRF3 PML TLR3
6 hepatitis c 30.5 DDX58 EIF2AK2 IRF3 TLR3
7 measles 30.4 DDX58 EIF2AK2 TLR3
8 west nile virus 30.0 DDX58 IRF3 TLR3
9 noonan syndrome 3 30.0 DDX58 IRF3 TBK1 TLR3
10 herpes simplex virus keratitis 12.7
11 congenital herpes simplex virus infection 12.6
12 congenital herpes simplex 12.5
13 eczema herpeticum 12.5
14 encephalopathy, acute, infection-induced 2 12.4
15 encephalopathy, acute, infection-induced 1 12.4
16 genital herpes 12.2
17 encephalopathy, acute, infection-induced 8 12.2
18 encephalopathy, acute, infection-induced 5 12.0
19 encephalopathy, acute, infection-induced 6 12.0
20 encephalopathy, acute, infection-induced 7 12.0
21 neonatal herpes 11.9
22 herpetic whitlow 11.7
23 mollaret meningitis 11.7
24 erythema multiforme 11.6
25 cytomegalovirus infection 11.6
26 proctitis 11.6
27 viral pneumonia 11.5
28 aphthous stomatitis 11.5
29 cytomegalic inclusion disease 11.5
30 immunodeficiency 31a 11.5
31 hyper-ige recurrent infection syndrome 2, autosomal recessive 11.2
32 caspase 8 deficiency 11.2
33 salivary gland disease 11.2
34 pseudomembranous conjunctivitis 11.2
35 herpetic gastritis 11.2
36 congenital intrauterine infection-like syndrome 11.2
37 pudendal neuralgia 11.2
38 recessive dystrophic epidermolysis bullosa-generalized other 11.2
39 torch syndrome 11.2
40 neurological consequences of cytomegalovirus infection 11.2
41 keratitis, hereditary 10.9
42 chickenpox 10.8
43 hepatitis 10.7
44 meningitis 10.6
45 stromal keratitis 10.6
46 esophagitis 10.6
47 blood group, gerbich system 10.6
48 glioma 10.5
49 bell's palsy 10.5
50 acute liver failure 10.5

Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to Herpes Simplex
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Symptoms & Phenotypes for Herpes Simplex

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UMLS symptoms related to Herpes Simplex:


fever, pruritus, snoring, halitosis, pelvic pain

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 CGAS CREB3 DDX58 EIF2AK2 HCFC1 IFI16
2 Decreased viability GR00221-A-1 9.89 EIF2AK2 TBK1
3 Decreased viability GR00221-A-2 9.89 EIF2AK2 TBK1
4 Decreased viability GR00221-A-3 9.89 EIF2AK2
5 Decreased viability GR00221-A-4 9.89 EIF2AK2
6 Decreased viability GR00301-A 9.89 EIF2AK2 TBK1
7 Decreased viability GR00342-S-1 9.89 EIF2AK2 TBK1 TLR3
8 Decreased viability GR00342-S-2 9.89 EIF2AK2 TBK1 TLR3
9 Decreased viability GR00402-S-2 9.89 EIF2AK2 TBK1 TLR3

MGI Mouse Phenotypes related to Herpes Simplex:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 CGAS DDX58 EIF2AK2 PILRA PML POU2F1
2 homeostasis/metabolism MP:0005376 10.1 CGAS DDX58 IRF3 NECTIN1 PILRA PML
3 immune system MP:0005387 10.1 CGAS DDX58 EIF2AK2 IRF3 PILRA PML
4 mortality/aging MP:0010768 9.83 CGAS DDX58 EIF2AK2 HCFC1 NECTIN1 PILRA
5 liver/biliary system MP:0005370 9.76 DDX58 HCFC1 PILRA POU2F1 TBK1 TICAM1
6 neoplasm MP:0002006 9.1 DDX58 EIF2AK2 PML TAP1 TICAM1 TLR3
Sources

Drugs & Therapeutics for Herpes Simplex

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Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 310)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Docosanol Approved, Investigational Phase 4 661-19-8, 30303-65-2 12620
2
Acyclovir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59277-89-3 2022
3
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 82410-32-0 3454
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
6
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
8
Tenofovir Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147127-20-6 464205
9
Metronidazole Approved Phase 4 443-48-1 4173
10
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
11
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
12
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
13
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
14
Miconazole Approved, Investigational, Vet_approved Phase 4,Early Phase 1 22916-47-8 4189
15
Nevirapine Approved Phase 4 129618-40-2 4463
16
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
17
Emtricitabine Approved, Investigational Phase 4,Not Applicable 143491-57-0 60877
18
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 5284616 6436030
19
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
20
Penciclovir Approved Phase 4,Phase 3 39809-25-1 4725
21
Famciclovir Approved, Investigational Phase 4,Phase 3,Phase 2 104227-87-4 3324
22
Difluprednate Approved Phase 4 23674-86-4 443936
23
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
24
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
25 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Ganciclovir triphosphate Phase 4,Phase 2,Phase 1,Not Applicable
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Antiparasitic Agents Phase 4,Phase 2
31 Antiprotozoal Agents Phase 4,Phase 2
32 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Ophthalmic Solutions Phase 4
34 Prednisolone acetate Phase 4,Phase 3
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Not Applicable
37 Autonomic Agents Phase 4,Phase 3,Phase 1
38 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Methylprednisolone Acetate Phase 4,Phase 3
40 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Neuroprotective Agents Phase 4,Phase 3
44 Dermatologic Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
45 Protective Agents Phase 4,Phase 3,Phase 2
46 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Antirheumatic Agents Phase 4,Phase 1
49 Gastrointestinal Agents Phase 4,Phase 3,Phase 1
50 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 315)
# Name Status NCT ID Phase Drugs
1 Comparison of Topical Antiviral Agents for Labial Cold Sores (Herpes Labialis) Unknown status NCT00467662 Phase 4 Acyclovir 5%;Docosanol 10%
2 PTH - Preemptive Treatment for Herpesviridae Unknown status NCT02152358 Phase 4 Aciclovir;Ganciclovir;Placebo
3 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Unknown status NCT00495716 Phase 4 acyclovir;acyclovir
4 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4 TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
5 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
6 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4 Valaciclovir;Placebo
7 Palatability Testing of a New Paediatric Formulation of Valacyclovir Completed NCT01682109 Phase 4 Valacyclovir
8 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4 valacyclovir;acyclovir
9 Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia Completed NCT01794897 Phase 4 Experimental: Valacyclovir treatment;Placebo comparator
10 A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons Completed NCT00161434 Phase 4 valacyclovir;placebo
11 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
12 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4 acyclovir
13 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4 acyclovir;valacyclovir
14 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4 Valaciclovir;Placebo
15 Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons Completed NCT01026454 Phase 4 acyclovir;valacyclovir
16 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4 valacyclovir
17 A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand Completed NCT00362596 Phase 4 acyclovir
18 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
19 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
20 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
21 Comparison Of 2 Doses Of Temsirolimus (Torisel) In Patients With Mantle Cell Lymphoma Completed NCT01180049 Phase 4 temsirolimus;temsirolimus
22 A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers Completed NCT00820534 Phase 4 Penciclovir;Placebo
23 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4 Famciclovir;Placebo
24 A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis Completed NCT00248144 Phase 4 Famciclovir
25 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4 Famciclovir
26 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4 Famciclovir
27 Melatonin Effects on Genital Herpes in Brazilian Women Recruiting NCT03831165 Phase 4 Acyclovir 400 MG
28 Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
29 The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis Terminated NCT02045082 Phase 4
30 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4 valacyclovir hydrochloride
31 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
32 Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Central Nervous System Unknown status NCT00006132 Phase 3 acyclovir
33 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
34 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
35 NB-001 Treatment of Recurrent Herpes Labialis Unknown status NCT01695187 Phase 3 NB-001 (0.3%);Placebo
36 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
37 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
38 Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old Completed NCT00224484 Phase 3
39 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
40 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3 ASP2151
41 Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine Completed NCT00224471 Phase 3
42 Phase III Study of ASP2151 in Herpes Simplex Patients Completed NCT01959295 Phase 3 ASP2151;ASP2151 placebo
43 Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients Completed NCT01602562 Phase 3 VACV tablets (Adults or pediatrics) or granules (pediatrics)
44 Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia Completed NCT00855309 Phase 3 acyclovir sodium
45 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
46 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3 Valaciclovir
47 Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection Completed NCT00098059 Phase 3 Famciclovir
48 Zinc for the Treatment of Herpes Simplex Labialis (HSL) Completed NCT00809809 Phase 3 Zicam (Ionic zinc);placebo
49 Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir Completed NCT00031486 Phase 3 Valacyclovir;Placebo
50 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3

Search NIH Clinical Center for Herpes Simplex

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: herpes simplex

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Genetic Tests for Herpes Simplex

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Anatomical Context for Herpes Simplex

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MalaCards organs/tissues related to Herpes Simplex:

42
Skin, T Cells, Brain, Eye, Liver, Testes, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

20
H, Face, Mouth, Genitalia
Sources

Publications for Herpes Simplex

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Articles related to Herpes Simplex:

(show top 50) (show all 6305)
# Title Authors Year
1
Herpes Simplex Virus Type-1 Infection: Associations with Inflammation and Cognitive Aging in Relation to Schizophrenia. ( 31049838 )
2019
2
Recurrent Aphthous Stomatitis Caused by Cytomegalovirus, Herpes Simplex Virus, and Candida Species in a Kidney Transplant Recipient: A Case Report. ( 30979493 )
2019
3
Combined testing for herpes simplex virus and Mycobacterium tuberculosis DNA in cerebrospinal fluid of patients with aseptic meningitis in Burkina Faso, West Africa. ( 30474140 )
2019
4
A case of herpes simplex virus reactivation after fractional ablative carbon dioxide laser to treat a burn scar. ( 30019972 )
2019
5
Inhibition of colorectal cancer liver metastasis in BALB/c mice following intratumoral injection of oncolytic herpes simplex virus type 2 for the induction of specific antitumor immunity. ( 30655834 )
2019
6
Congenital cytomegalic inclusion disease with disseminated Herpes simplex infection. ( 31025643 )
2019
7
Hyperammonemia in a case of herpes simplex and anti-N-methyl-d-aspartate receptor encephalitis. ( 30961960 )
2019
8
Efficacy of acyclovir for herpes simplex encephalitis: A protocol for a systematic review of randomized controlled trial. ( 30985731 )
2019
9
Acute retinal necrosis following herpes simplex encephalitis: a nationwide survey in Japan. ( 31054049 )
2019
10
Corilagin Interferes With Toll-Like Receptor 3-Mediated Immune Response in Herpes Simplex Encephalitis. ( 31080403 )
2019
11
The recruitment of peripheral blood leukocytes to the brain is delayed in susceptible BALB/c compared to resistant C57BL/6 mice during herpes simplex virus encephalitis. ( 30758810 )
2019
12
Cerebral Venous Thrombosis as Rare Presentation of Herpes Simplex Virus Encephalitis. ( 30800483 )
2019
13
Continuous Electroencephalogram as a Biomarker of Disease Progression and Severity in Herpes Simplex Virus-1 Encephalitis. ( 30873853 )
2019
14
Herpes simplex virus encephalitis update. ( 30921087 )
2019
15
Suspected Herpes Simplex Encephalitis with Low Copy Number DNA. ( 30607771 )
2019
16
An Adult Case of Herpes Simplex Virus-Associated Granulomatous Encephalitis. ( 30626834 )
2019
17
Acyclovir Unresponsive Herpes Simplex Encephalitis in a child successfully treated with the addition of Foscarnet: Case report. ( 30652455 )
2019
18
Recurrent Herpes Simplex Virus Encephalitis After Epilepsy Surgery. ( 30665474 )
2019
19
Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis. ( 30683700 )
2019
20
Anti-NMDAR Encephalitis in Association with Herpes Simplex Virus and Viral and Bacterial Zoonoses. ( 30692769 )
2019
21
Mouse model of anti-NMDA receptor post-herpes simplex encephalitis. ( 30697582 )
2019
22
Mechanisms of Blood-Brain Barrier Disruption in Herpes Simplex Encephalitis. ( 30456443 )
2019
23
Evaluation of cholinergic functions in patients with Japanese encephalitis and Herpes simplex encephalitis. ( 30468725 )
2019
24
Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report. ( 30653172 )
2019
25
Recurrence of herpes simplex virus endotheliitis in a Descemet membrane endothelial keratoplasty graft: mimicking fungal interface infection. ( 31064790 )
2019
26
Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease. ( 30725296 )
2019
27
Herpes Simplex Virus Esophagitis. ( 31106821 )
2019
28
Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement. ( 30654754 )
2019
29
Herpes Simplex-Like Fixed Drug Eruption Induced by Fluconazole Without Cross-reactivity to Itraconazole. ( 30829805 )
2019
30
The Effect of Hormonal Contraception and Menstrual Cycle Timing on Genital Herpes Simplex Virus-2 Shedding and Lesions. ( 30148758 )
2019
31
Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Recurrent Genital Herpes. ( 30787156 )
2019
32
Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. ( 30279232 )
2019
33
Oncolytic herpes simplex virus therapy for malignant glioma: Current approaches to successful clinical application. ( 31046478 )
2019
34
LAT inhibits apoptosis via downregulation of components of type I IFN pathway during latent HSV-1 ocular infection. ( 30814286 )
2019
35
Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population. ( 30814317 )
2019
36
Co-infection of Herpes Simplex Virus Type 2 and HIV Infections among Pregnant Women in Ibadan, Nigeria. ( 30814831 )
2019
37
Prevalence of herpes simplex virus-1 in hospitalized adult patients with clinical diagnosis of meningoencephalitis using real-time polymerase chain reaction: A single-center, cross-sectional study. ( 30815020 )
2019
38
Contribution of Human Herpesvirus 8 and Herpes Simplex Type 2 to Progression of Carotid Intima-Media Thickness in People Living With HIV. ( 30815506 )
2019
39
Therapeutic Challenges and Prognosis of Descemet's Membrane Endothelial Keratoplasty in Herpes Simplex Eye Disease. ( 30817327 )
2019
40
Bilateral Herpes Simplex Virus-related Peripheral Ulcerative Keratitis Leading to Corneal Perforation in a Patient with Primary Herpes Simplex Virus Infection. ( 30820293 )
2019
41
Herpes Simplex Infection During Pregnancy, Results of a Tertiary Referral Center in Turkey. ( 30831604 )
2019
42
The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection. ( 30837340 )
2019
43
The Combination of Dimorphandra gardneriana Galactomannan and Mangiferin Inhibits Herpes Simplex and Poliovirus. ( 30848197 )
2019
44
Molecular analyses and phylogeny of the herpes simplex virus 2 US9 and glycoproteins gE/gI obtained from infected subjects during the Herpevac Trial for Women. ( 30849089 )
2019
45
Bilateral herpes simplex keratitis: lactation a trigger for recurrence! ( 30852508 )
2019
46
Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: model-based predictions. ( 30853029 )
2019
47
A comparison of the Quidel Solana HSV 1 + 2/VZV Assay, the Focus Diagnostics Simplexa HSV 1 & 2 Direct Assay and the Luminex Aries HSV 1&2 Assay for detection of herpes simplex virus 1 and 2 from swab specimens. ( 30856386 )
2019
48
Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus. ( 30858222 )
2019
49
Herpes Simplex Virus Infections in Solid Organ Transplantation - Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. ( 30859647 )
2019
50
Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders. ( 30863282 )
2019
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Variations for Herpes Simplex

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Expression for Herpes Simplex

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LifeMap Discovery
Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 FCN1 ficolin (collagen/fibrinogen domain containing) 1 Skin + 3.89 0.000
2 IRF1 interferon regulatory factor 1 Skin + 3.58 0.000
3 STAT1 signal transducer and activator of transcription 1, 91kDa Skin + 3.53 0.000
4 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 Skin + 3.49 0.000
5 SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 Skin + 3.41 0.000
6 CCL19 chemokine (C-C motif) ligand 19 Skin + 3.32 0.003
7 XAF1 XIAP associated factor 1 Skin + 3.04 0.000
Search GEO for disease gene expression data for Herpes Simplex.
Sources

Pathways for Herpes Simplex

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Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.65 CGAS DDX58 EIF2AK2 IFI16 IRF3 NECTIN2
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.19 DDX58 EIF2AK2 IRF3 PML POU2F1 TNFRSF14
3
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 12.91 IFI16 IRF3 TBK1 TICAM1 TLR3 TRAF3
4
PI3K-Akt signaling pathway 38
Show member pathways
 12.81 CREB3 EIF2AK2 IRF3 TBK1 TICAM1 TLR3
5
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.58 CGAS DDX58 IRF3 TBK1 TICAM1 TLR3
6
4-1BB Pathway 65
Show member pathways
 12.51 CREB3 EIF2AK2 PML TBK1 TRAF3
7
Human cytomegalovirus infection 38
Show member pathways
 12.49 CGAS CREB3 DDX58 EIF2AK2 IRF3 TAP1
8
TRAF Pathway 65
Show member pathways
 12.4 CREB3 IRF3 TBK1 TICAM1 TLR3 TNFRSF14
9
Interferon gamma signaling 67
Show member pathways
 12.35 DDX58 EIF2AK2 IRF3 PML
10
VEGF Pathway (Qiagen) 65
Show member pathways
 12.25 CREB3 IRF3 TBK1 TICAM1 TLR3
11
Cytosolic sensors of pathogen-associated DNA 67
Show member pathways
 12.21 CGAS DDX58 IFI16 IRF3 TBK1 TICAM1
12
Viral carcinogenesis 38
12.13 CREB3 EIF2AK2 IRF3 TRAF3
13
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.08 IRF3 TBK1 TICAM1 TLR3 TRAF3
14
NF-kappaB Signaling 4
11.79 DDX58 IFI16 IRF3 TAP1 TAP2 TBK1
15
NF-kappa B signaling pathway 38
11.72 DDX58 TICAM1 TRAF3
16
Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics 62
Show member pathways
 10.99 DDX58 EIF2AK2 IRF3
Sources

GO Terms for Herpes Simplex

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Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.73 CREB3 PML TAP1 TAP2 TLR3 UNC93B1
2 endoplasmic reticulum GO:0005783 9.7 CREB3 PML POU2F1 TAP1 TAP2 TLR3
3 apical junction complex GO:0043296 9.37 NECTIN1 NECTIN2
4 cell-cell contact zone GO:0044291 9.32 NECTIN1 NECTIN2
5 MHC class I peptide loading complex GO:0042824 8.96 TAP1 TAP2
6 TAP complex GO:0042825 8.62 TAP1 TAP2

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 IRF3 TBK1 TICAM1 TLR3
2 response to virus GO:0009615 9.86 DDX58 EIF2AK2 TBK1 TLR3
3 defense response to virus GO:0051607 9.85 CGAS DDX58 EIF2AK2 IFI16 IRF3 PML
4 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.81 TBK1 TICAM1 TLR3
5 positive regulation of interleukin-6 production GO:0032755 9.81 DDX58 TICAM1 TLR3
6 positive regulation of type I interferon production GO:0032481 9.8 CGAS IFI16 IRF3 TBK1 TICAM1 TLR3
7 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.77 IRF3 TBK1 TICAM1 TLR3 TRAF3
8 immune system process GO:0002376 9.77 CGAS DDX58 EIF2AK2 IFI16 IRF3 PML
9 toll-like receptor signaling pathway GO:0002224 9.76 TLR3 TRAF3 UNC93B1
10 negative regulation of type I interferon production GO:0032480 9.75 DDX58 IRF3 TBK1
11 positive regulation of cytokine production GO:0001819 9.74 EIF2AK2 IFI16 TLR3
12 positive regulation of interferon-beta production GO:0032728 9.71 DDX58 IRF3 TBK1 TLR3
13 activation of innate immune response GO:0002218 9.7 CGAS IFI16 TBK1
14 cellular response to exogenous dsRNA GO:0071360 9.69 CGAS DDX58 TLR3
15 positive regulation of interferon-alpha production GO:0032727 9.67 DDX58 IRF3 TBK1
16 positive regulation of chemokine production GO:0032722 9.66 EIF2AK2 TLR3
17 necroptotic process GO:0070266 9.66 TICAM1 TLR3
18 regulation of type I interferon production GO:0032479 9.65 IRF3 TBK1
19 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.65 TICAM1 TLR3
20 peptide transport GO:0015833 9.65 TAP1 TAP2
21 toll-like receptor 3 signaling pathway GO:0034138 9.65 TICAM1 TLR3 UNC93B1
22 positive regulation of chemokine biosynthetic process GO:0045080 9.64 TICAM1 TLR3
23 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.63 TAP1 TAP2
24 positive regulation of interferon-beta biosynthetic process GO:0045359 9.63 TBK1 TICAM1 TLR3
25 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.62 TICAM1 TLR3
26 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.62 DDX58 TICAM1
27 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668 9.61 TAP1 TAP2
28 response to exogenous dsRNA GO:0043330 9.61 DDX58 TICAM1 TLR3
29 detection of virus GO:0009597 9.6 DDX58 TLR3
30 virion attachment to host cell GO:0019062 9.59 NECTIN1 NECTIN2
31 cytosol to ER transport GO:0046967 9.55 TAP1 TAP2
32 viral process GO:0016032 9.44 CREB3 DDX58 EIF2AK2 HCFC1 IRF3 NECTIN1
33 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 CREB3 DDX58 HCFC1 IFI16 IRF3 POU2F1
34 innate immune response GO:0045087 10 CGAS DDX58 EIF2AK2 IFI16 IRF3 PML

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.78 DDX58 PML TNFRSF14 TRAF3
2 double-stranded DNA binding GO:0003690 9.69 CGAS DDX58 IFI16
3 virus receptor activity GO:0001618 9.61 NECTIN1 NECTIN2 TNFRSF14
4 protein binding GO:0005515 9.6 CGAS CREB3 DDX58 EIF2AK2 HCFC1 IFI16
5 identical protein binding GO:0042802 9.56 DDX58 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2
6 double-stranded RNA binding GO:0003725 9.54 DDX58 EIF2AK2 TLR3
7 MHC class I protein binding GO:0042288 9.49 PILRA TAP1
8 MHC protein binding GO:0042287 9.46 TAP1 TAP2
9 peptide transmembrane transporter activity GO:1904680 9.4 TAP1 TAP2
10 TAP1 binding GO:0046978 9.32 TAP1 TAP2
11 MHC class Ib protein binding GO:0023029 9.26 TAP1 TAP2
12 peptide antigen-transporting ATPase activity GO:0015433 9.16 TAP1 TAP2
Sources

Sources for Herpes Simplex

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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