Herpes Simplex disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HRP006 MIFTS: 70	Herpes Simplex Categories: Infectious diseases, Rare diseases
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Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Name: Herpes Simplex ¹² ⁵⁵ ⁴³ ⁴⁴ ¹⁵

Herpesvirus Hominis Disease ¹²

Herpes Simplex Infections ⁷³

Herpes Simplex Disease ⁷⁶

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Viral infections characterized by skin and mucous membrane lesions

Herpesviral [herpes simplex] infections

Herpesviral infection, unspecified

External Ids:

Disease Ontology ¹² DOID:8566

ICD10 ³³ B00 B00.9

ICD9CM ³⁵ 054

MeSH ⁴⁴ D006561

SNOMED-CT ⁶⁸ 88594005

UMLS ⁷³ C0019348

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Summaries for Herpes Simplex

MedlinePlus : ⁴³ Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and acute retinal necrosis syndrome, and has symptoms including fever, pruritus and snoring. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Acyclovir and Docosanol have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and t cells, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : ¹² A viral infectious disease that results in_formation_of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : ⁷⁶ Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and... more...

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Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 593)

#	Related Disease	Score	Top Affiliating Genes
1	herpes simplex encephalitis	34.5	IRF3 TBK1 TLR3 TRAF3 UNC93B1
2	acute retinal necrosis syndrome	32.5	NECTIN1 TNFRSF14
3	encephalitis	32.1	IRF3 TLR3 TRAF3 UNC93B1
4	viral infectious disease	31.2	EIF2AK2 IRF3 TBK1 TLR3 TLR9
5	rabies	30.3	IRF3 PML TLR3
6	influenza	29.9	EIF2AK2 IRF3 PML TLR3 TLR9
7	herpes simplex virus keratitis	12.6
8	congenital herpes simplex virus infection	12.6
9	congenital herpes simplex	12.4
10	eczema herpeticum	12.4
11	encephalopathy, acute, infection-induced 1	12.3
12	genital herpes	12.2
13	encephalopathy, acute, infection-induced 2	12.1
14	encephalopathy, acute, infection-induced 8	11.9
15	neonatal herpes	11.8
16	encephalopathy, acute, infection-induced 5	11.7
17	herpetic whitlow	11.6
18	mollaret meningitis	11.6
19	encephalopathy, acute, infection-induced 6	11.6
20	encephalopathy, acute, infection-induced 7	11.6
21	erythema multiforme	11.6
22	cytomegalovirus infection	11.5
23	proctitis	11.5
24	viral pneumonia	11.5
25	aphthous stomatitis	11.5
26	cytomegalic inclusion disease	11.5
27	hyper-ige recurrent infection syndrome, autosomal recessive	11.2
28	caspase 8 deficiency	11.2
29	immunodeficiency 31a	11.2
30	salivary gland disease	11.2
31	pseudomembranous conjunctivitis	11.2
32	herpetic gastritis	11.2
33	congenital intrauterine infection-like syndrome	11.2
34	pudendal neuralgia	11.2
35	recessive dystrophic epidermolysis bullosa-generalized other	11.2
36	torch syndrome	11.2
37	neurological consequences of cytomegalovirus infection	11.2
38	stromal keratitis	10.6
39	hepatitis	10.6
40	meningitis	10.6
41	keratitis, hereditary	10.5
42	bell's palsy	10.5
43	acute liver failure	10.5
44	pneumonia	10.4
45	chickenpox	10.4
46	facial paralysis	10.4
47	alzheimer disease	10.4
48	glioma	10.4
49	human immunodeficiency virus type 1	10.4
50	myelitis	10.4

Graphical network of the top 20 diseases related to Herpes Simplex:

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Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:

fever, pruritus, snoring, pelvic pain, halitosis

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	10.36	EIF2AK2 TBK1
2	Decreased viability	GR00221-A-2	10.36	EIF2AK2 TBK1
3	Decreased viability	GR00221-A-3	10.36	EIF2AK2
4	Decreased viability	GR00221-A-4	10.36	EIF2AK2
5	Decreased viability	GR00301-A	10.36	EIF2AK2 TBK1
6	Decreased viability	GR00342-S-1	10.36	EIF2AK2 TBK1 TLR3
7	Decreased viability	GR00342-S-2	10.36	EIF2AK2 TBK1 TLR3
8	Decreased viability	GR00402-S-2	10.36	EIF2AK2 TBK1 TLR3 CREB3 HCFC1 IFI16
9	no effect	GR00402-S-1	9.62	CREB3 EIF2AK2 HCFC1 IFI16 IRF3 NECTIN1

MGI Mouse Phenotypes related to Herpes Simplex:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.97	EIF2AK2 PILRA PML POU2F1 TAP1 TAP2
2	immune system	MP:0005387	9.77	EIF2AK2 IRF3 PILRA PML TAP1 TAP2
3	mortality/aging	MP:0010768	9.47	EIF2AK2 HCFC1 NECTIN1 PILRA PML POU2F1

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Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 295)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acyclovir

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

59277-89-3

2022

Docosanol

Approved, Investigational

Phase 4

30303-65-2, 661-19-8

12620

Ganciclovir

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

82410-32-0

3454

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3

2921-57-5

Metronidazole

Approved

Phase 4

443-48-1

4173

Dinoprost Tromethamine

Approved, Vet_approved

Phase 4

38562-01-5

5282415

Bimatoprost

Approved, Investigational

Phase 4

155206-00-1

5311027

Dinoprost

Approved, Investigational

Phase 4

551-11-1

5283078

Mycophenolic acid

Approved

Phase 4,Phase 3

24280-93-1

446541

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Early Phase 1

22916-47-8

4189

Ritonavir

Approved, Investigational

Phase 4,Phase 3

155213-67-5

392622

Emtricitabine

Approved, Investigational

Phase 4,Not Applicable

143491-57-0

60877

Nevirapine

Approved

Phase 4

129618-40-2

4463

Penciclovir

Approved

Phase 4,Phase 3

39809-25-1

4725

Famciclovir

Approved, Investigational

Phase 4,Phase 3,Phase 2

104227-87-4

3324

Difluprednate

Approved

Phase 4

23674-86-4

443936

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3

2920-86-7

Tenofovir

Experimental, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

147127-20-6

464205

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Antiviral Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Ganciclovir triphosphate

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Antiparasitic Agents

Phase 4,Phase 2

Antiprotozoal Agents

Phase 4,Phase 2

valacyclovir

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Ophthalmic Solutions

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Protective Agents

Phase 4,Phase 3,Phase 2

Autonomic Agents

Phase 4,Phase 3,Phase 1

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antirheumatic Agents

Phase 4,Phase 1

Gastrointestinal Agents

Phase 4,Phase 3,Phase 1

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 1,Not Applicable

Dermatologic Agents

Phase 4,Phase 2,Not Applicable,Early Phase 1

Prednisolone acetate

Phase 4,Phase 3

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunoglobulin G

Phase 4,Phase 2,Phase 1

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Methylprednisolone acetate

Phase 4,Phase 3

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

glucocorticoids

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antibodies

Phase 4,Phase 2,Phase 1,Not Applicable

Immunoglobulins

Phase 4,Phase 2,Phase 1,Not Applicable

Neuroprotective Agents

Phase 4,Phase 3

Reverse Transcriptase Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 316)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Topical Antiviral Agents for Labial Cold Sores (Herpes Labialis)	Unknown status	NCT00467662	Phase 4	Acyclovir 5%;Docosanol 10%
2	PTH - Preemptive Treatment for Herpesviridae	Unknown status	NCT02152358	Phase 4	Aciclovir;Ganciclovir;Placebo
3	Effect of HSV-2 Suppressive Therapy on Sexual Behavior	Unknown status	NCT00495716	Phase 4	acyclovir;acyclovir
4	Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding	Completed	NCT01448616	Phase 4	TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
5	Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study	Completed	NCT00464542	Phase 4	Metronidazole
6	Palatability Testing of a New Paediatric Formulation of Valacyclovir	Completed	NCT01682109	Phase 4	Valacyclovir
7	A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies.	Completed	NCT00158860	Phase 4	valaciclovir (VALTREX®)
8	Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV	Completed	NCT00527618	Phase 4	valacyclovir;acyclovir
9	Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia	Completed	NCT01794897	Phase 4	Experimental: Valacyclovir treatment;Placebo comparator
10	A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons	Completed	NCT00161434	Phase 4	valacyclovir;placebo
11	Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2	Completed	NCT01346475	Phase 4	valacyclovir;Valacyclovir
12	A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation	Completed	NCT00723229	Phase 4	acyclovir
13	Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2	Completed	NCT00362297	Phase 4	acyclovir;valacyclovir
14	VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies.	Completed	NCT00116844	Phase 4	Valaciclovir;Placebo
15	Valacyclovir vs. Acyclovir as HSV-2 Suppressive Therapy: Effect on Plasma HIV-1 Levels Among HIV-1/HSV-2 Co-infected Persons	Completed	NCT01026454	Phase 4	acyclovir;valacyclovir
16	VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2	Completed	NCT00306293	Phase 4	valacyclovir
17	A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand	Completed	NCT00362596	Phase 4	acyclovir
18	Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study)	Completed	NCT02059655	Phase 4	Bimatoprost;Eye drop solution
19	A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation	Completed	NCT00048165	Phase 4	Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
20	Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT)	Completed	NCT00552240	Phase 4	tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
21	A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers	Completed	NCT00820534	Phase 4	Penciclovir;Placebo
22	Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients	Completed	NCT00477334	Phase 4	Famciclovir;Placebo
23	A Study to Evaluate the Safety and Efficacy of Single Day or Single Dose Famciclovir for the Treatment of Recurrent Herpes Labialis	Completed	NCT00248144	Phase 4	Famciclovir
24	RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir	Completed	NCT00219310	Phase 4	Famciclovir
25	A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding	Completed	NCT00129818	Phase 4	Famciclovir
26	A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis	Not yet recruiting	NCT03626376	Phase 4	oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
27	The Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis	Terminated	NCT02045082	Phase 4
28	A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons	Terminated	NCT00079911	Phase 4	valacyclovir hydrochloride
29	A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients	Unknown status	NCT00005663	Phase 3	Valacyclovir hydrochloride
30	Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Central Nervous System	Unknown status	NCT00006132	Phase 3	acyclovir
31	Herpetic Eye Disease Study (HEDS) I	Unknown status	NCT00000138	Phase 3	Prednisolone Phosphate;Acyclovir
32	Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community	Unknown status	NCT00124878	Phase 3
33	NB-001 Treatment of Recurrent Herpes Labialis	Unknown status	NCT01695187	Phase 3	NB-001 (0.3%);Placebo
34	Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease	Completed	NCT00699764	Phase 3
35	Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects	Completed	NCT00698568	Phase 3
36	Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old	Completed	NCT00224484	Phase 3
37	Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth	Completed	NCT00031447	Phase 3	Acyclovir;Placebo
38	Open-label Study of ASP2151 in Herpes Simplex Patients	Completed	NCT02209324	Phase 3	ASP2151
39	Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine	Completed	NCT00224471	Phase 3
40	Phase III Study of ASP2151 in Herpes Simplex Patients	Completed	NCT01959295	Phase 3	ASP2151;ASP2151 placebo
41	Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients	Completed	NCT01602562	Phase 3	VACV tablets (Adults or pediatrics) or granules (pediatrics)
42	Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia	Completed	NCT00855309	Phase 3	acyclovir sodium
43	Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates	Completed	NCT00031460	Phase 3	Acyclovir;Placebo
44	Valaciclovir to Prevent Transmission of Herpes Simplex Virus	Completed	NCT00001649	Phase 3	Valaciclovir
45	Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection	Completed	NCT00098059	Phase 3	Famciclovir
46	Zinc for the Treatment of Herpes Simplex Labialis (HSL)	Completed	NCT00809809	Phase 3	Zicam (Ionic zinc);placebo
47	Long Term Treatment of Herpes Simplex Encephalitis (HSE) With Valacyclovir	Completed	NCT00031486	Phase 3	Valacyclovir;Placebo
48	HerpeVac Trial for Young Women	Completed	NCT00057330	Phase 3
49	Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth	Completed	NCT00006135	Phase 3	acyclovir
50	Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth	Completed	NCT00004757	Phase 3	acyclovir

Search NIH Clinical Center for Herpes Simplex

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

acyclovir

acyclovir sodium

benzocaine

benzocaine pwdr

famciclovir

herpes simplex virus nucleoside analog dna polymerase inhibitor [epc]

herpes simplex virus pyrophosphate analog dna polymerase inhibitor [epc]

methylene blue

valacyclovir

valacyclovir hydrochloride

Cochrane evidence based reviews: herpes simplex

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Genetic Tests for Herpes Simplex

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Anatomical Context for Herpes Simplex

MalaCards organs/tissues related to Herpes Simplex:

⁴¹

Skin, Brain, T Cells, Eye, Testes, Liver, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

¹⁹

H, Face, Mouth, Genitalia

Sources

Publications for Herpes Simplex

Articles related to Herpes Simplex:

(show top 50) (show all 4595)

#	Title	Authors	Year
1	Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2. ( 30412859 )	Bourne N...Milligan GN	2019
2	Corrigendum: Inhibitory effect of Spirogyra spp. algal extracts against herpes simplex virus type 1 and 2 infection. ( 30556242 )	Deethae A...Tragoolpua Y	2019
3	Corrigendum to "Antibody-based immunotherapy of acyclovir resistant ocular herpes simplex virus infection" [Virology 512 (2017) 194-200]. ( 30290967 )	Bauer D...Krawczyk A	2019
4	Herpes simplex virus type-1 infection affects the expression of extracellular matrix components in human nucleus pulposus cells. ( 30339788 )	Alpantaki K...Sourvinos G	2019
5	Severe acyclovir-resistant herpes simplex virus 1 infection following cord blood transplantation. ( 29923124 )	Shigemura T....Okuyama R.	2018
6	Descemet membrane endothelial keratoplasty for corneal decompensation caused by herpes simplex virus endotheliitis. ( 29502597 )	Asi F....Seitz B.	2018
7	Infectivity and growth kinetics of Herpes Simplex Virus type-2 in MOLT4 CCR5+ and CEM CCR5+ T cell lines. ( 29944889 )	Desai D....Kulkarni S.	2018
8	Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus-infected pregnant women: Results of a pilot study. ( 29905034 )	Nickodem C....Taylor B.D.	2018
9	A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient. ( 29446473 )	Okamoto M....Hide M.	2018
10	Herpes Simplex Virus 1 Dramatically Alters Loading and Positioning of RNA Polymerase II on Host Genes Early in Infection. ( 29437966 )	Birkenheuer C.H....Baines J.D.	2018
11	Pneumomediastinum and Pneumothorax Associated with Herpes Simplex Virus (HSV) Pneumonia. ( 29379004 )	LA^pez-Rivera F....Garcia Puebla J.	2018
12	Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences. ( 29928582 )	Ali R....Nasheuer H.P.	2018
13	The apical region of the herpes simplex virus major capsid protein promotes capsid maturation. ( 29976665 )	Ruhge L.L....Smith G.A.	2018
14	Extracellular vesicles released by herpes simplex virus 1 infected cells block virus replication in recipient cells in a STING-dependent manner. ( 29976662 )	Deschamps T....Kalamvoki M.	2018
15	Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis. ( 29345511 )	Wensing B....de Boer J.H.	2018
16	Roles of the Phosphorylation of Herpes Simplex Virus 1 UL51 at a Specific Site in Viral Replication and Pathogenicity. ( 29976672 )	Kato A....Kawaguchi Y.	2018
17	Why do herpes simplex encephalitis and semantic dementia show a different pattern of semantic impairment in spite of their main common involvement within the anterior temporal lobes? ( 29573378 )	Gainotti G.	2018
18	Neonatal herpes simplex virus infections. ( 29544668 )	Pinninti S.G....Kimberlin D.W.	2018
19	Autoimmune Encephalitis Following Herpes Simplex Virus Encephalitis in an Infant. ( 29629704 )	Ramesh V....Sankar J.	2018
20	Clinical significance of IgM and IgA class anti-NMDAR antibodies in herpes simplex encephalitis. ( 29698873 )	Westman G....RAPnnelid J.	2018
21	Proteomic Analysis of Secretomes of Oncolytic Herpes Simplex Virus-Infected Squamous Cell Carcinoma Cells. ( 29360750 )	Tada S....Yura Y.	2018
22	Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time. ( 29920588 )	Shipley M.M....Szpara M.L.	2018
23	Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern? ( 29356762 )	van Oeffelen L....Op de Coul E.	2018
24	Corneal perforation after noncontact tonometry in patients with active recurrent herpes simplex keratitis: case report. ( 29417444 )	Tananuvat N....Tangmonkongvoragul C.	2018
25	Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. ( 29113740 )	Quenelle D.C....Prichard M.N.	2018
26	Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis. ( 29749113 )	Cabrera-Aguas M....Watson S.	2018
27	Pregnancy-related Hemophagocytic Lymphohistiocytosis Associated with Herpes Simplex Virus-2 Infection: A Diagnostic Dilemma. ( 29796364 )	Nasser M.F....Duggal A.	2018
28	A Novel System for Constructing a Recombinant Highly-Attenuated Vaccinia Virus Strain (LC16m8) Expressing Foreign Genes and Its Application for the Generation of LC16m8-Based Vaccines against Herpes Simplex Virus 2. ( 29709968 )	Omura N....Saijo M.	2018
29	Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. ( 29370719 )	Tang R....Hu K.	2018
30	A case of herpes simplex virus pneumonia detected by sputum cytodiagnosis. ( 29375858 )	Yoshimi M....Mori M.	2018
31	QuickStats: Age-Adjusted* Trends in the Prevalence of Herpes Simplex Virus Type 1 (HSV-1) and Herpes Simplex Virus Type 2 (HSV-2) Among Adolescents and Adults Aged 14-49 Years - United States, 1999-2000 Through 2015-2016. ( 29447144 )		2018
32	Prevention and management of genital herpes simplex infection during pregnancy and delivery: Guidelines from the French College of Gynaecologists and Obstetricians (CNGOF). ( 29571124 )	SAcnat M.V....Sentilhes L.	2018
33	A Rare Case of Concurrent Herpes Simplex Encephalitis and Glioblastoma Multiforme. ( 29492128 )	Sayal P....Highley R.	2018
34	Deep RNA Sequencing Reveals a Repertoire of Human Fibroblast Circular RNAs Associated with Cellular Responses to Herpes Simplex Virus 1 Infection. ( 29972822 )	Shi J....Hu Y.	2018
35	Semantic language deficit developing following herpes simplex encephalitis: reorganization &quot;cannibalising&quot; language centers? ( 29350572 )	Mangelsdorf S....Walterfang M.	2018
36	ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. ( 29371118 )	Bin L....Leung D.Y.M.	2018
37	Disseminated herpes simplex virus: a case of eczema herpeticum causing viral encephalitis. ( 29741524 )	Finlow C....Thomas J.	2018
38	Analysis of Select Herpes Simplex Virus 1 (HSV-1) Proteins for Restriction of Human Immunodeficiency Virus Type 1 (HIV-1): HSV-1 gM Protein Potently Restricts HIV-1 by Preventing Intracellular Transport and Processing of Env gp160. ( 29093081 )	Polpitiya Arachchige S....Stephens E.B.	2018
39	Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. ( 29256984 )		2018
40	Disseminated herpes simplex virus and varicella zoster virus co-infection in an immunocompetent patient. ( 29451195 )		2018
41	Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains. ( 29427675 )		2018
42	CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection. ( 29437926 )		2018
43	Acute Disseminated Encephalomyelitis After Herpes Simplex Virus Meningoencephalitis in Adult. ( 29581077 )		2018
44	Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion. ( 29046455 )		2018
45	Herpes simplex encephalitis relapse associated with positive N-methyl-D-aspartate receptor antibodies. ( 29450730 )		2018
46	Fulminant Herpes Simplex Virus Type I Encephalitis Despite Maximal Medical Therapy. ( 29900087 )		2018
47	A case report of myocarditis combined with hepatitis caused by herpes simplex virus. ( 29970006 )		2018
48	The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication. ( 29263259 )		2018
49	Prevalence of Herpes Simplex Virus Type 1 and Type 2 in Persons Aged 14-49: United States, 2015-2016. ( 29442994 )		2018
50	Cellular Anti-Silencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate-Early Gene Expression. ( 29950408 )		2018

Sources

Genes for Herpes Simplex

Genes related to Herpes Simplex (0 elite genes):

(show all 36)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NECTIN1	Nectin Cell Adhesion Molecule 1	Protein Coding	84.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Gene name Summaries Proteins Pathways & Interactions Functions (show sections)	9861033 12915538 12885915 (more) 15731277 10482562 11836420 18502984 11544254 20455098 20089288 12915568 19129446 17005657 14963155 15972328 11531408 11483743 11437670 15534229 11069980 19521665 18005714 10627537 15273289 18803666
2	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	72.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Summaries Proteins Pathways & Interactions Functions (show sections)	11119586 9657005 19915044 (more) 11511354 18005714 12915568 12915538 11164894 19426226 12368332 12466117 18502984
3	HCFC1	Host Cell Factor C1	Protein Coding	70.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Summaries Proteins Pathways & Interactions Functions (show sections)	12456665 16042417 12271126 (more) 15190068 12670868 1684335 10637318 17698583 16282471 11711630 9223485 16633736 12743030 9334261 20126307 19016376 18520591 12244100 15705566 10871379 10629049 10196288 8392914 10398682 10984507 9123865 10958670 14532282 8454622 12235138
4	NECTIN2	Nectin Cell Adhesion Molecule 2	Protein Coding	69.57	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Summaries Proteins Pathways & Interactions Functions (show sections)	12915538 11602758 12915581
5	TLR3	Toll Like Receptor 3	Protein Coding	59.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Pathways & Interactions Variants (show sections)	19025601 16847112
6	UNC93B1	Unc-93 Homolog B1, TLR Signaling Regulator	Protein Coding	55.45	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
7	TBK1	TANK Binding Kinase 1	Protein Coding	49.94	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Proteins Pathways & Interactions (show sections)
8	PML	Promyelocytic Leukemia	Protein Coding	49.55	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)	19279115 10574707 10233977 (more) 9151854 12186918 12610143 9658103 11485412 11602710
9	IRF3	Interferon Regulatory Factor 3	Protein Coding	46.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)	12917470 17215277 16603509
10	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	44.1	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)	16414988 9765401 9223497 (more) 9023344 11773369 9696792 12414939 17229694 11070019 15174900
11	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	43.53	GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
12	TAP2	Transporter 2, ATP Binding Cassette Subfamily B Member	Protein Coding	43.28	GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
13	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	42.22	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Summaries Functions (show sections)	9271389 10871379
14	TBP	TATA-Box Binding Protein	Protein Coding	42.11	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)	8798634 7479838 15081896
15	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	41.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)
16	TNFSF14	TNF Superfamily Member 14	Protein Coding	40.9	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)	12466117 12566458 15814693 (more) 16131544 15115612 19426226 18412315 15546385 17010447 12651068 16275888
17	TLR9	Toll Like Receptor 9	Protein Coding	40.56	DISEASES inferred ¹⁵ ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19755019 17085599 19025601 (more) 18082566 11927638 16847112
18	IFI16	Interferon Gamma Inducible Protein 16	Protein Coding	39.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions localization (show sections)
19	POU2F1	POU Class 2 Homeobox 1	Protein Coding	36.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Proteins Functions (show sections)	1684335 1358755 7568211 (more) 7891704 16282471 1406672 8284200 10398682 12271126 7642649 8441632 1645782 9315674
20	PILRA	Paired Immunoglobin Like Type 2 Receptor Alpha	Protein Coding	33.98	GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
21	IFNA1	Interferon Alpha 1	Protein Coding	28.86	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Pathways & Interactions (show sections)	1719612 2153279 2158516 (more) 1379288 7852835 8863993 13130472 14969765 15320906 15622449 2172409 7697520 8724854 10652752 11836673 2168998 2264889 1719613 1331251 8031058 8380210 8181190 7855636 8578993 9139085 9637497 9707372 11482999 15727684 12687260 11544466 9335431 8887056 8830796 8709261 1666118 1695643 18653740 15163721 14963171 12893749 9802930 12209136 12738374 16000865 8103535 8027590 8091644 8711430 14742635 11927638 12224508 12845770 15753256 16603509 1883515 11488639 11689663 1655906
22	DDX58	DExD/H-Box Helicase 58	Protein Coding	28.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
23	C3	Complement C3	Protein Coding	28.63	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
24	CD209	CD209 Molecule	Protein Coding	28.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions (show sections)
25	CASP8	Caspase 8	Protein Coding	28.26	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
26	ITGAV	Integrin Subunit Alpha V	Protein Coding	27.49	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions (show sections)
27	TICAM1	Toll Like Receptor Adaptor Molecule 1	Protein Coding	27.44	GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)
28	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	27.31	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
29	IFNB1	Interferon Beta 1	Protein Coding	27.16	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Pathways & Interactions (show sections)	11883188 16439992 16603509 (more) 1666118 15727684 9335431 14963171 1463323
30	HS3ST3B1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1	Protein Coding	25.84	GeneCards inferred via : Publications Summaries Functions (show sections)
31	ACKR1	Atypical Chemokine Receptor 1 (Duffy Blood Group)	Protein Coding	25.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8388365 12021353 7911177 (more) 12885915 14556904 9696802 9837796 12225814 15016549 18468509 18573279 7576569 9346834 11119586 10627537 7490454 7572464 1780614 1645898 15619895 17299053 15273289 17164784 16213178 12381352 9684378 9525660 1667262 16221064 16044540 7494331 9879759 7745699 18651758 18076965 11090178 19386594 18667634 16288376 15534229 18723002 18193057 12417744 11394975 10225292 10559300 15546385 12915581 12915568 12829851 12504254 12537725 8278393 20089288 8038227 1652468 1713774 2164044 19702506 16131544 12692272 11851316 8585768 8133093 18671825 15864815 14711338 10482637 11162814
32	GTF2B	General Transcription Factor IIB	Protein Coding	25.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Proteins (show sections)	14764096 7791769 8972203 (more) 11371188 8392607 10449590 15081896
33	HCFC2	Host Cell Factor C2	Protein Coding	25.36	GeneCards inferred via : Publications Summaries Pathways & Interactions (show sections)
34	SP100	SP100 Nuclear Antigen	Protein Coding	25.08	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Pathways & Interactions (show sections)	7626019 1310226 7828630 (more) 18160441 19279115
35	TMEM173	Transmembrane Protein 173	Protein Coding	24.92	GeneCards inferred via : Publications Proteins Functions (show sections)
36	POLR2A	RNA Polymerase II Subunit A	Protein Coding	24.26	GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)

Sources

Variations for Herpes Simplex

Sources

Expression for Herpes Simplex

Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: ³⁵

#	Gene	Description	Tissue	Up/Dn	Fold Change (log2)	P value
1	FCN1	ficolin (collagen/fibrinogen domain containing) 1	Skin	+	3.89	0.000
2	IRF1	interferon regulatory factor 1	Skin	+	3.58	0.000
3	STAT1	signal transducer and activator of transcription 1, 91kDa	Skin	+	3.53	0.000
4	RARRES3	retinoic acid receptor responder (tazarotene induced) 3	Skin	+	3.49	0.000
5	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	Skin	+	3.41	0.000
6	CCL19	chemokine (C-C motif) ligand 19	Skin	+	3.32	0.003
7	XAF1	XIAP associated factor 1	Skin	+	3.04	0.000

Search GEO for disease gene expression data for Herpes Simplex.

Sources

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.73	EIF2AK2 IFI16 IRF3 NECTIN2 PML POU2F1
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.2	EIF2AK2 IRF3 PML POU2F1 TNFRSF14 TNFSF14
3	Human cytomegalovirus infection ³⁷ Show member pathways Hepatitis B ³⁷ Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	12.89	CREB3 EIF2AK2 IRF3 TAP1 TAP2 TBK1
4	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.86	CREB3 EIF2AK2 IRF3 TBK1 TBP TLR3
5	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.85	IFI16 IRF3 TBK1 TLR3 TLR9 TRAF3
6	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.57	CREB3 EIF2AK2 PML TBK1 TBP TRAF3
7	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.29	CREB3 IRF3 TBK1 TLR3 TLR9 TNFRSF14
8	VEGF Pathway (Qiagen) ²² Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴ VEGF Pathway ⁶⁴	12.28	CREB3 IRF3 TBK1 TLR3 TLR9
9	Cytosolic sensors of pathogen-associated DNA ⁶⁶ Show member pathways DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁶ IkBA variant leads to EDA-ID ⁶⁶ IKBKB deficiency causes SCID ⁶⁶ IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) ⁶⁶ IRF3 mediated activation of type 1 IFN ⁶⁶ IRF3-mediated induction of type I IFN ⁶⁶ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁶ Regulation by TREX1 ⁶⁶ Regulation of innate immune responses to cytosolic DNA ⁶⁶ RIP-mediated NFkB activation via ZBP1 ⁶⁶ STAT6-mediated induction of chemokines ⁶⁶ STING mediated induction of host immune responses ⁶⁶ TAK1 activates NFkB by phosphorylation and activation of IKKs complex ⁶⁶ TRAF6 mediated NF-kB activation ⁶⁶ ZBP1(DAI) mediated induction of type I IFNs ⁶⁶	12.27	IFI16 IRF3 TBK1 TLR3
10	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.21	EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2 PILRA
11	Viral carcinogenesis ³⁷	12.16	CREB3 EIF2AK2 IRF3 TBP TRAF3
12	Diseases associated with the TLR signaling cascade ⁶⁶ Show member pathways Diseases of Immune System ⁶⁶ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁶ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁶ IRAK4 deficiency (TLR2/4) ⁶⁶ IRAK4 deficiency (TLR5) ⁶⁶ MyD88 deficiency (TLR2/4) ⁶⁶ MyD88 deficiency (TLR5) ⁶⁶ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.11	IRF3 TBK1 TLR3 TLR9 TRAF3
13	Epstein-Barr virus infection ³⁷	12.1	EIF2AK2 IRF3 TAP1 TAP2 TBK1 TRAF3
14	NF-kappaB Signaling ⁴	12.07	IFI16 IRF3 TAP1 TAP2 TBK1 TLR3
15	Hepatitis C ³⁷	11.88	EIF2AK2 IRF3 TBK1 TLR3 TRAF3
16	T Cell Co-Signaling Pathway: Ligand-Receptor Interactions ⁶⁵	11.48	NECTIN2 TNFRSF14 TNFSF14
17	Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶¹ Show member pathways Inhibition of PKR ⁶⁶	10.93	EIF2AK2 IRF3

Sources

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endosome	GO:0005768	9.83	PML TLR3 TLR9 TRAF3 UNC93B1
2	endoplasmic reticulum	GO:0005783	9.76	CREB3 PML POU2F1 TAP1 TAP2 TLR3
3	endoplasmic reticulum membrane	GO:0005789	9.5	CREB3 PML TAP1 TAP2 TLR3 TLR9
4	apical junction complex	GO:0043296	9.48	NECTIN1 NECTIN2
5	cell-cell contact zone	GO:0044291	9.46	NECTIN1 NECTIN2
6	endolysosome membrane	GO:0036020	9.37	TLR3 TLR9
7	early phagosome	GO:0032009	9.32	TLR9 UNC93B1
8	MHC class I peptide loading complex	GO:0042824	9.26	TAP1 TAP2
9	TAP complex	GO:0042825	8.62	TAP1 TAP2
10	membrane	GO:0016020	10.28	CREB3 EIF2AK2 HCFC1 IFI16 NECTIN1 NECTIN2

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 32)

#	Name	GO ID	Score	Top Affiliating Genes
1	innate immune response	GO:0045087	9.91	EIF2AK2 IFI16 IRF3 PML TBK1 TLR3
2	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.88	IRF3 TBK1 TLR3 TLR9
3	response to virus	GO:0009615	9.83	EIF2AK2 TBK1 TLR3
4	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.79	TNFRSF14 TNFSF14 TRAF3
5	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.78	TBK1 TLR3 TLR9
6	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.78	EIF2AK2 TLR3 TLR9 TNFSF14
7	defense response to virus	GO:0051607	9.76	EIF2AK2 IFI16 IRF3 PML TBK1 TLR3
8	toll-like receptor signaling pathway	GO:0002224	9.73	TLR3 TLR9 TRAF3 UNC93B1
9	positive regulation of cytokine production	GO:0001819	9.71	EIF2AK2 IFI16 TLR3
10	positive regulation of type I interferon production	GO:0032481	9.71	IFI16 IRF3 TBK1 TLR3
11	immune system process	GO:0002376	9.7	EIF2AK2 IFI16 IRF3 PML TAP1 TAP2
12	positive regulation of chemokine production	GO:0032722	9.67	EIF2AK2 TLR3 TLR9
13	positive regulation of interferon-beta production	GO:0032728	9.67	IRF3 TBK1 TLR3 TLR9
14	activation of innate immune response	GO:0002218	9.65	IFI16 TBK1
15	toll-like receptor 9 signaling pathway	GO:0034162	9.65	TLR9 UNC93B1
16	positive regulation of interferon-alpha production	GO:0032727	9.64	IRF3 TBK1
17	positive regulation of interferon-gamma biosynthetic process	GO:0045078	9.64	TLR3 TLR9
18	I-kappaB phosphorylation	GO:0007252	9.63	TLR3 TLR9
19	regulation of type I interferon production	GO:0032479	9.63	IRF3 TBK1
20	positive regulation of interferon-beta biosynthetic process	GO:0045359	9.63	TBK1 TLR3 TLR9
21	toll-like receptor 3 signaling pathway	GO:0034138	9.62	TLR3 UNC93B1
22	peptide transport	GO:0015833	9.62	TAP1 TAP2
23	TRIF-dependent toll-like receptor signaling pathway	GO:0035666	9.62	IRF3 TBK1 TLR3 TRAF3
24	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO:0019885	9.6	TAP1 TAP2
25	cellular response to dsRNA	GO:0071359	9.59	IRF3 TLR3
26	vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	GO:1990668	9.58	TAP1 TAP2
27	virion attachment to host cell	GO:0019062	9.57	NECTIN1 NECTIN2
28	positive regulation of interferon-alpha biosynthetic process	GO:0045356	9.56	TLR3 TLR9
29	positive regulation of toll-like receptor signaling pathway	GO:0034123	9.55	TLR3 TLR9
30	cytosol to ER transport	GO:0046967	9.52	TAP1 TAP2
31	viral process	GO:0016032	9.44	CREB3 EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2
32	positive regulation of transcription by RNA polymerase II	GO:0045944	10.11	CREB3 HCFC1 IFI16 IRF3 POU2F1 TBK1

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:0042803	9.93	IRF3 NECTIN1 NECTIN2 PML TAP1 TLR9
2	identical protein binding	GO:0042802	9.87	EIF2AK2 HCFC1 IRF3 NECTIN1 NECTIN2 TBK1
3	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.8	CREB3 IFI16 IRF3 POU2F1 TBP
4	virus receptor activity	GO:0001618	9.61	NECTIN1 NECTIN2 TNFRSF14
5	protein binding	GO:0005515	9.58	CREB3 EIF2AK2 HCFC1 IFI16 IRF3 NECTIN1
6	MHC class I protein binding	GO:0042288	9.49	PILRA TAP1
7	MHC protein binding	GO:0042287	9.48	TAP1 TAP2
8	peptide transmembrane transporter activity	GO:1904680	9.37	TAP1 TAP2
9	TAP1 binding	GO:0046978	9.26	TAP1 TAP2
10	MHC class Ib protein binding	GO:0023029	9.16	TAP1 TAP2
11	peptide antigen-transporting ATPase activity	GO:0015433	8.96	TAP1 TAP2

Sources

Sources for Herpes Simplex

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Herpes Simplex

Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Classifications:

External Ids:

Summaries for Herpes Simplex

Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Herpes Simplex:

Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Herpes Simplex:

Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: herpes simplex

Genetic Tests for Herpes Simplex

Anatomical Context for Herpes Simplex

MalaCards organs/tissues related to Herpes Simplex:

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

Publications for Herpes Simplex

Articles related to Herpes Simplex:

Genes for Herpes Simplex

Genes related to Herpes Simplex (0 elite genes):

Variations for Herpes Simplex

Expression for Herpes Simplex

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

Sources for Herpes Simplex

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :