Herpes Simplex disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HRP006 MIFTS: 65	Herpes Simplex Categories: Fetal diseases, Infectious diseases, Oral diseases, Rare diseases, Reproductive diseases
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Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Name: Herpes Simplex ¹² ⁵⁴ ⁴² ⁴³ ¹⁵

Herpesvirus Hominis Disease ¹²

Herpes Simplex Infections ⁷¹

Herpes Simplex Disease ⁷⁴

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases Fetal diseases
Anatomical: Reproductive diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Certain infectious and parasitic diseases

Viral infections characterized by skin and mucous membrane lesions

Herpesviral [herpes simplex] infections

Herpesviral infection, unspecified

External Ids:

Disease Ontology ¹² DOID:8566

ICD9CM ³⁴ 054

MeSH ⁴³ D006561

NCIt ⁴⁹ C155871

SNOMED-CT ⁶⁷ 88594005

ICD10 ³² B00.9

UMLS ⁷¹ C0019348

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Summaries for Herpes Simplex

MedlinePlus : ⁴² Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and genital herpes, and has symptoms including fever, pruritus and snoring. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Hydrocortisone acetate and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include mouth, face and genitalia, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : ¹² A viral infectious disease that results in formation of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : ⁷⁴ Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human... more...

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Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1209)

#	Related Disease	Score	Top Affiliating Genes
1	herpes simplex encephalitis	35.2	UNC93B1 TRAF3 TLR3 TICAM1 TBK1 IRF3
2	genital herpes	34.4	TNFRSF14 NECTIN1 IFI16
3	herpetic whitlow	33.6	TNFRSF14 PILRA NECTIN1
4	acute retinal necrosis syndrome	33.3	TNFRSF14 NECTIN1
5	encephalitis	32.6	UNC93B1 TRAF3 TLR3 TICAM1 IRF3 IFNA1
6	viral encephalitis	31.9	UNC93B1 TLR3 IFNA1 DDX58
7	stomatitis	31.7	IFNA1 EIF2AK2 DDX58
8	measles	31.5	TLR3 IRF3 IFNA1 EIF2AK2 DDX58
9	acute necrotizing encephalitis	31.4	UNC93B1 NECTIN1
10	hepatitis a	31.3	TLR3 TICAM1 IFNA1
11	mumps	31.3	TLR3 IFNA1 EIF2AK2
12	viral infectious disease	31.3	TLR3 TBK1 IRF3 IFNA1 EIF2AK2 DDX58
13	hepatitis	31.2	TICAM1 TBK1 IRF3 IFNA1 EIF2AK2 DDX58
14	kaposi sarcoma	31.2	TLR3 TBK1 IRF3 IFNA1 IFI16
15	newcastle disease	31.0	TLR3 IRF3 IFNA1 EIF2AK2 DDX58
16	rabies	31.0	TLR3 PML IRF3 IFNA1 DDX58
17	tick-borne encephalitis	30.9	TLR3 IFNA1 DDX58
18	mouth disease	30.9	TLR3 IRF3 IFNA1 DDX58
19	herpangina	30.8	TLR3 IRF3 IFNA1 DDX58
20	hepatitis c	30.6	TLR3 TBK1 IRF3 IFNA1 EIF2AK2 DDX58
21	west nile virus	30.3	IRF3 IFNA1 DDX58
22	severe acute respiratory syndrome	30.2	TRAF3 TBK1 IRF3 IFNA1 DDX58
23	influenza	30.1	TRAF3 TLR3 PML IRF3 IFNA1 EIF2AK2
24	congenital herpes simplex	12.8
25	herpes simplex virus keratitis	12.8
26	eczema herpeticum	12.6
27	herpes simplex virus stromal keratitis	12.5
28	encephalopathy, acute, infection-induced 2	12.5
29	encephalopathy, acute, infection-induced 1	12.5
30	encephalopathy, acute, infection-induced 8	12.3
31	encephalopathy, acute, infection-induced 5	12.1
32	encephalopathy, acute, infection-induced 7	12.1
33	encephalopathy, acute, infection-induced 6	12.1
34	neonatal herpes	12.0
35	erythema multiforme	11.9
36	mollaret meningitis	11.8
37	cytomegalovirus infection	11.7
38	proctitis	11.7
39	aphthous stomatitis	11.7
40	viral pneumonia	11.7
41	cytomegalic inclusion disease	11.7
42	immunodeficiency 31a	11.6
43	herpetic gastritis	11.6
44	hyper-ige recurrent infection syndrome 2, autosomal recessive	11.3
45	hydrocephalus, endocardial fibroelastosis, and cataracts	11.3
46	caspase 8 deficiency	11.3
47	immunodeficiency 62	11.3
48	salivary gland disease	11.3
49	pseudomembranous conjunctivitis	11.3
50	congenital intrauterine infection-like syndrome	11.3

Graphical network of the top 20 diseases related to Herpes Simplex:

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Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:

fever, pruritus, snoring, halitosis, pelvic pain

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

²⁶ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00221-A-1	10.03	EIF2AK2 TBK1
2	Decreased viability	GR00221-A-2	10.03	EIF2AK2 TBK1
3	Decreased viability	GR00221-A-3	10.03	EIF2AK2
4	Decreased viability	GR00221-A-4	10.03	EIF2AK2
5	Decreased viability	GR00249-S	10.03	CREB3 TBK1 TICAM1 TLR3 TRAF3
6	Decreased viability	GR00301-A	10.03	EIF2AK2 TBK1
7	Decreased viability	GR00342-S-1	10.03	TBK1 TLR3
8	Decreased viability	GR00342-S-2	10.03	TBK1 TLR3
9	Decreased viability	GR00386-A-1	10.03	CREB3 TAP1 UNC93B1
10	Decreased viability	GR00402-S-2	10.03	TBK1 TICAM1 TLR3 TNFRSF14
11	Increased the percentage of infected cells	GR00402-S-1	8.32	TLR3

MGI Mouse Phenotypes related to Herpes Simplex:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.21	DDX58 EIF2AK2 IRF3 PILRA PML POU2F1
2	homeostasis/metabolism	MP:0005376	10.13	CREB3 DDX58 IFI16 IRF3 NECTIN1 PILRA
3	immune system	MP:0005387	10.1	DDX58 EIF2AK2 IFI16 IRF3 PILRA PML
4	mortality/aging	MP:0010768	9.83	CREB3 DDX58 EIF2AK2 HCFC1 NECTIN1 PILRA
5	liver/biliary system	MP:0005370	9.76	DDX58 HCFC1 PILRA POU2F1 TBK1 TICAM1
6	neoplasm	MP:0002006	9.1	DDX58 EIF2AK2 PML TAP1 TICAM1 TLR3

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Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 282)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Metronidazole

Approved

Phase 4

443-48-1

4173

Bisoprolol

Approved

Phase 4

66722-44-9

2405

Difluprednate

Approved

Phase 4

23674-86-4

443936

Acyclovir

Approved

Phase 4

59277-89-3

2022

Ganciclovir

Approved, Investigational

Phase 4

82410-32-0

3454

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

Anti-Inflammatory Agents

Phase 4

Hydrocortisone 17-butyrate 21-propionate

Phase 4

Hydrocortisone hemisuccinate

Phase 4

Antiprotozoal Agents

Phase 4

Denatonium

Phase 4

Neurotransmitter Agents

Phase 4

Antihypertensive Agents

Phase 4

Adrenergic Antagonists

Phase 4

Adrenergic Agents

Phase 4

Adrenergic beta-Antagonists

Phase 4

Adrenergic beta-1 Receptor Antagonists

Phase 4

Sympatholytics

Phase 4

valacyclovir

Phase 4

Ophthalmic Solutions

Phase 4

Ganciclovir triphosphate

Phase 4

Methylprednisolone Acetate

Phase 4

Neuroprotective Agents

Phase 4

Protective Agents

Phase 4

mometasone furoate

Approved, Investigational, Vet_approved

Phase 3

83919-23-7

Zinc

Approved, Investigational

Phase 3

7440-66-6

32051

Famciclovir

Approved, Investigational

Phase 3

104227-87-4

3324

Halofantrine

Approved

Phase 3

69756-53-2

37393

Aluminum sulfate

Approved

Phase 3

10043-01-3

Vidarabine

Approved, Investigational

Phase 3

24356-66-9

21704 32326

Penciclovir

Approved

Phase 3

39809-25-1

4725

Sargramostim

Approved, Investigational

Phase 3

83869-56-1, 123774-72-1

Sodium citrate

Approved, Investigational

Phase 3

68-04-2

Valganciclovir

Approved, Investigational

Phase 3

175865-60-8

64147

Azithromycin

Approved

Phase 3

83905-01-5

447043 55185

Lopinavir

Approved

Phase 3

192725-17-0

92727

chloroquine

Approved, Investigational, Vet_approved

Phase 3

54-05-7

2719

Hydroxychloroquine

Approved

Phase 3

118-42-3

3652

Ritonavir

Approved, Investigational

Phase 3

155213-67-5

392622

Oseltamivir

Approved

Phase 3

204255-11-8, 196618-13-0

65028

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 3

77-92-9

311

BCG vaccine

Investigational

Phase 3

Anti-Allergic Agents

Phase 3

Interventional clinical trials:

(show top 50) (show all 305)

#	Name	Status	NCT ID	Phase	Drugs
1	The Safety, Efficacy and Convenience of Use of the Natural Agent "Superlysin Gel" as Treatment for Herpes Labialis in Comparison to Acyclovir 5% and Docozanole 10%.	Unknown status	NCT00467662	Phase 4	Acyclovir 5%;Docosanol 10%
2	Palatability Testing of a New Paediatric Formulation of Valacyclovir for the Prophylaxis and Treatment of VZV and HSV Infections in Children	Completed	NCT01682109	Phase 4	Valacyclovir
3	Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 Shedding	Completed	NCT00464542	Phase 4	Metronidazole
4	Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia	Completed	NCT01794897	Phase 4	Experimental: Valacyclovir treatment;Placebo comparator
5	Effect of Tenofovir on Genital HSV Shedding: a Randomized, Double-blind, Placebo-controlled Clinical Trial	Completed	NCT01448616	Phase 4	TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
6	A Randomized, Double-Blind, Placebo Controlled Crossover Trial Using Valacyclovir to Suppress HSV and HIV Shedding in HIV-1, HSV-2 Coinfected Persons	Completed	NCT00161434	Phase 4	valacyclovir;placebo
7	An International, Randomized, Double-Blind, Placebo-Controlled, Multicenter, 6-Month Study of the Efficacy and Safety of Valtrex 1g QD vs. Placebo for the Suppression of HSV-2 Genital Herpes in Newly Diagnosed Immunocompetent Patients	Completed	NCT00158860	Phase 4	Valaciclovir;Placebo
8	A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of Acyclovir on Rapidly Cleared Herpes Simplex Virus Type 2 Genital Reactivation Episodes in Herpes Simplex Virus-2 Seropositive Adults	Completed	NCT00723229	Phase 4	acyclovir
9	A Randomized, Open-label, Crossover Trial of the Effect of Dosing of Daily HSV-2 Suppressive Therapy on HSV Reactivation and Plasma HIV-1 Levels Among HIV-1/ HSV-2 Co-infected Persons	Completed	NCT00527618	Phase 4	valacyclovir;acyclovir
10	A Randomized Controlled Crossover Trial of Acylcovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand	Completed	NCT00362596	Phase 4	acyclovir
11	A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of High-Dose Acyclovir Versus Once Daily Valacyclovir on Herpes Simplex Virus Type 2 Genital Shedding in Herpes Simplex Virus-2 Seropositive Adults	Completed	NCT00362297	Phase 4	acyclovir;valacyclovir
12	A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of High-Dose Valacyclovir Versus Once Daily Valacyclovir on Herpes Simplex Virus Type 2 Genital Shedding in Herpes Simplex Virus-2 Seropositive Adults	Completed	NCT01346475	Phase 4	valacyclovir;Valacyclovir
13	Bisoprolol Versus Corticosteroid and Bisoprolol Combination for Prophylaxis Against Atrial Fibrillation After on Pump Coronary Artery Bypass Surgery	Completed	NCT03800264	Phase 4	Bisoprolol
14	A Prospective, Double-masked, Placebo Controlled Comparison of Topical 0.15% Ganciclovir Gel (Zirgan®) Versus 0.3% Hypromellose Gel (Genteal Gel®; Placebo) for the Treatment of Adenovirus Conjunctivitis	Completed	NCT01533480	Phase 4	Zirgan;genteal gel
15	A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis	Recruiting	NCT03626376	Phase 4	oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
16	Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy of 2LHERP® in Patients With Recurrent Orofacial Herpes Infections.	Recruiting	NCT04065971	Phase 4	2LHERP®;Placebo
17	Efficacy of a Preemptive Treatment by Ganciclovir or by Aciclovir in ICU Patients Requiring Prolonged Mechanical Ventilation and Presenting a Viral Replication (CMV and/or HSV) - Prospective, Randomized, Double-blinded Multicenter Trial	Active, not recruiting	NCT02152358	Phase 4	Aciclovir;Ganciclovir;Placebo
18	Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy of 2LHERP® in Patients With Recurrent Genital Herpes Infections	Not yet recruiting	NCT04235322	Phase 4	2LHERP®;Placebo
19	Low Dose Versus High Dose Steroids in Treatment of Viral Encephalitis	Not yet recruiting	NCT04103684	Phase 4	Methylprednisolone;Dexamethasone
20	Comparison Between the Sensibility of the Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis	Terminated	NCT02045082	Phase 4
21	A Comparative Study of Tzanck Smear With Methylene Blue Versus Giemsa Stain to Diagnose Herpes Simplex, Herpes Zoster and Varicella Zoster Skin Infections	Unknown status	NCT03178747	Phase 3
22	Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Central Nervous System	Unknown status	NCT00006132	Phase 3	acyclovir
23	Herpetic Eye Disease Study (HEDS) I	Unknown status	NCT00000138	Phase 3	Prednisolone Phosphate;Acyclovir
24	An International, Randomized, Double-Blind, Placebo-Controlled Study of Valacyclovir for the Suppression of Recurrent Ano-Genital HSV Infections in HIV-Infected Subjects	Unknown status	NCT00005663	Phase 3	Valacyclovir hydrochloride
25	MULTICENTER, RANDOMIZED, DOUBLE BLIND, CONTROLLED, CLINICAL STUDY TO DEMONSTRATE THE THERAPEUTIC CLINICAL EQUIVALENCE OF TWO MOMETASONE NASAL SPRAYS IN THE RELIEF OF THE SIGNS AND SYMPTOMS OF PERENNIAL ALLERGIC RHINITIS.	Unknown status	NCT01702103	Phase 3	Mometasone furoate
26	Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community	Unknown status	NCT00124878	Phase 3
27	A Randomized, Double-Blind Trial of Valacyclovir Hydrochloride (BW 256U87) Prophylaxis for Opportunistic Cytomegalovirus End-Organ Disease in Patients With Advanced HIV Infection (< 100 CD4+ Lymphocytes)	Completed	NCT00001038	Phase 3	Valacyclovir hydrochloride;Acyclovir
28	Open-label Study of ASP2151 in Herpes Simplex Patients	Completed	NCT02209324	Phase 3	ASP2151
29	Study to Evaluate the Safety of GSK Biologicals' Herpes Simplex Candidate Vaccine (gD2t) With MPL in HSV Seropositive or Seronegative Subjects Without Genital Herpes Disease	Completed	NCT00698568	Phase 3
30	Safety of SmithKline Beecham Biologicals' Herpes Simplex Candidate Vaccine (gD2t) With MPL & Its Efficacy to Prevent Genital Herpes Disease in HSV Positive or Negative Consorts of Subjects With Genital Herpes Disease	Completed	NCT00699764	Phase 3
31	A Study to Evaluate the Immunogenicity and Safety of GlaxoSmithKline Biologicals' Herpes Simplex Candidate Vaccine (gD2‑AS04) in Healthy HSV Seronegative and Seropositive Female Subjects Aged 10-17 Years.	Completed	NCT00224484	Phase 3
32	Phase III Study of ASP2151 in Herpes Simplex Patients ― A Double-blind, Placebo-controlled Study ―	Completed	NCT01959295	Phase 3	ASP2151;ASP2151 placebo
33	Low Dose Versus Weight-based Intravenous Acyclovir for Herpes Simplex Virus Prophylaxis in the Neutropenic Patient	Completed	NCT00855309	Phase 3	acyclovir sodium
34	A Multicenter, Open-label, Single-arm, Two-step Study to Evaluate the Safety and Single-dose Pharmacokinetics of Famciclovir and Multiple-dose Safety After Administration of Famciclovir Oral Pediatric Formulation to Children 1 to 12 Years of Age With Herpes Simplex Infection	Completed	NCT00098059	Phase 3	Famciclovir
35	Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Infection in Patients With the Acquired Immunodeficiency Syndrome: A Randomized Multicenter Study of Foscarnet Versus Vidarabine	Completed	NCT00000985	Phase 3	Vidarabine;Acyclovir;Foscarnet sodium
36	A Phase III, Double-blind, Randomized, Study to Compare: 1) the Immunogenicity and Safety of 3 Commercial Scale Consistency Lots of GlaxoSmithKline (GSK) Biologicals' Herpes Simplex Candidate Vaccine in Healthy HSV-1 and -2 Seronegative (HSV 1-/2-) Female Subjects Aged 10 - 17 Years, and 2) Vaccine Immunogenicity in Healthy HSV 1-/2- Females Aged 10 - 17 Years With Healthy HSV 1-/2- Adult Females	Completed	NCT00224471	Phase 3
37	Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, Eyes, and Mouth	Completed	NCT00006135	Phase 3	acyclovir
38	A Multicenter, Open-label Study to Evaluate Preventive Efficacy for Herpes Simplex Virus Infection and Safety of 256U87 (Valaciclovir Hydrochloride) in Adult and Pediatric Hematopoietic Stem Cell Transplantation Patients	Completed	NCT01602562	Phase 3	VACV tablets (Adults or pediatrics) or granules (pediatrics)
39	An Open Label, Multi-Centre, Phase III, Subject Initiated Safety Study of ME-609 in Treatment of Recurrent Herpes Simplex Labialis in Adolescents	Completed	NCT00375570	Phase 3	ME-609
40	Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis	Completed	NCT02265913	Phase 3	Acyclovir 5 percent (Perrigo);Acyclovir 5 percent (Reference);Placebo cream
41	Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth	Completed	NCT00004757	Phase 3	acyclovir
42	VALacyclovir In Delaying Antiretroviral Treatment Entry	Completed	NCT00860977	Phase 3	valacyclovir;Placebo
43	A Randomized, Double-Blind, Active Controlled, Vehicle-Controlled, Subject Initiated Study Comparing Efficacy and Safety of ME-609 Versus Acyclovir Cream for Treatment of Recurrent Herpes Simplex Labialis	Completed	NCT00361881	Phase 3	ME-609;acyclovir in ME-609 vehicle;Vehicle
44	A Prospective, Randomized, Multicenter Study of the Efficacy and Safety of Famciclovir 125 mg Comparing to Aciclovir 200 mg in Patients With Active Recurrent Genital Herpes	Completed	NCT01281007	Phase 3	Famciclovir;Aciclovir
45	A Randomized, Double-Blind, to Compare Non-inferiority Efficacy and Safety of Penciclovir 10mg/g to Acyclovir 50mg/g in the Treatment of Recurrent Herpes Labialis.	Completed	NCT01257074	Phase 3	Acyclovir 50mg/g;Penciclovir 10mg/g
46	A Randomized, Double-blind, Placebo-controlled, Multi-Center Trial of Zinc for the Treatment of Herpes Simplex Labialis (HSL)	Completed	NCT00809809	Phase 3	Zicam (Ionic zinc);placebo
47	A Phase III Double-Blind, Placebo-Controlled Trial of Long Term Therapy of Herpes Simplex Encephalitis (HSE): An Evaluation of Valacyclovir (CASG-204)	Completed	NCT00031486	Phase 3	Valacyclovir;Placebo
48	A Placebo-Controlled Phase III Evaluation of Suppressive Therapy With Oral Acyclovir Suspension Following Neonatal Herpes Simplex Virus Infections Limited to the Skin, Eye, and Mouth	Completed	NCT00031447	Phase 3	Acyclovir;Placebo
49	A Multicenter, Open-label, Single-arm Study to Evaluate the Safety and Pharmacokinetics of Famciclovir Single 1500 mg Dose in Adolescents With Recurrent Herpes Labialis	Completed	NCT00878072	Phase 2, Phase 3	Famciclovir
50	A Randomized, Double-Blind, Placebo-Controlled Evaluation of Valaciclovir for the Prevention of Herpes Simplex Virus Transmission in Heterosexual Couples	Completed	NCT00001649	Phase 3	Valaciclovir

Search NIH Clinical Center for Herpes Simplex

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Acyclovir

Acyclovir Sodium

Benzocaine

BENZOCAINE PWDR

famciclovir

Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]

Herpes Simplex Virus Pyrophosphate Analog DNA Polymerase Inhibitor [EPC]

Methylene blue

valacyclovir

Valacyclovir hydrochloride

Cochrane evidence based reviews: herpes simplex

Sources

Genetic Tests for Herpes Simplex

Sources

Anatomical Context for Herpes Simplex

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

¹⁹

Mouth, Face, Genitalia, Hands

MalaCards organs/tissues related to Herpes Simplex:

⁴⁰

T Cells, Brain, Testes, Skin, Eye, Liver, Endothelial

Sources

Publications for Herpes Simplex

Articles related to Herpes Simplex:

(show top 50) (show all 30267)

#	Title	Authors	PMID	Year
1	Herpes simplex virus encephalitis of childhood: inborn errors of central nervous system cell-intrinsic immunity. ⁴² ⁶¹	Zhang SY	32040615	2020
2	Inflammatory pseudotumor associated with HSV infection of rectal vascular endothelium in a patient with HIV: a case report and literature review. ⁶¹ ⁴²	Bai S...Yang MX	32192456	2020
3	Intranasal pain in a patient with Behçet's disease. ⁴²	Tsunoda K...Endo R	32161027	2020
4	A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics. ⁵⁴ ⁶¹	Puntel M...Castro MG	20375153	2010
5	Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion. ⁵⁴ ⁶¹	Atanasiu D...Eisenberg RJ	20130048	2010
6	Glycoprotein D actively induces rapid internalization of two nectin-1 isoforms during herpes simplex virus entry. ⁵⁴ ⁶¹	Stiles KM...Krummenacher C	20089288	2010
7	Herpes simplex virus tegument ICP0 is capsid associated, and its E3 ubiquitin ligase domain is important for incorporation into virions. ⁵⁴ ⁶¹	Delboy MG...Nicola AV	19906912	2010
8	Fusion between perinuclear virions and the outer nuclear membrane requires the fusogenic activity of herpes simplex virus gB. ⁶¹ ⁵⁴	Wright CC...Johnson DC	19759132	2009
9	Engineered herpes simplex viruses efficiently infect and kill CD133+ human glioma xenograft cells that express CD111. ⁶¹ ⁵⁴	Friedman GK...Yancey Gillespie G	19521665	2009
10	Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs. ⁶¹ ⁵⁴	Hoshino Y...Cohen JI	19702506	2009
11	[Expression of blood Toll-like receptors and cytokines in children with recurrent herpes simplex]. ⁶¹ ⁵⁴	Tang JP...Sun L	19755019	2009
12	Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain. ⁶¹ ⁵⁴	Gianni T...Campadelli-Fiume G	19386594	2009
13	Differential functions of interferon-upregulated Sp100 isoforms: herpes simplex virus type 1 promoter-based immediate-early gene suppression and PML protection from ICP0-mediated degradation. ⁶¹ ⁵⁴	Negorev DG...Maul GG	19279115	2009
14	Cytotoxicity and antiangiogenesis by fibroblast growth factor 2-targeted Ad-TK cancer gene therapy. ⁵⁴ ⁶¹	Saito K...O'Malley BW	19213040	2009
15	Generation of herpesvirus entry mediator (HVEM)-restricted herpes simplex virus type 1 mutant viruses: resistance of HVEM-expressing cells and identification of mutations that rescue nectin-1 recognition. ⁵⁴ ⁶¹	Uchida H...Glorioso JC	19129446	2009
16	A 10-year molecular survey of herpes simplex virus type 1 in Germany demonstrates a stable and high prevalence of genotypes A and B. ⁵⁴ ⁶¹	Schmidt-Chanasit J...Doerr HW	19186100	2009
17	Delivery of Interferon-gamma by an adenovirus vector blocks herpes simplex virus Type 1 reactivation in vitro and in vivo independent of RNase L and double-stranded RNA-dependent protein kinase pathways. ⁶¹ ⁵⁴	Carr DJ...Stuart PM	19042034	2009
18	Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs. ⁶¹ ⁵⁴	Quenelle DC...Kern ER	18573279	2008
19	Multiple sclerosis: reduced proportion of circulating plasmacytoid dendritic cells expressing BDCA-2 and BDCA-4 and reduced production of IL-6 and IL-10 in response to herpes simplex virus type 1. ⁶¹ ⁵⁴	Sanna A...Sotgiu S	18653740	2008
20	Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells. ⁶¹ ⁵⁴	Tiwari V...Shukla D	18803666	2008
21	Involvement of HVEM receptor in activation of nuclear factor kappaB by herpes simplex virus 1 glycoprotein D. ⁶¹ ⁵⁴	Sciortino MT...Mastino A	18671825	2008
22	Therapeutic efficacy of a herpes simplex virus with radiation or temozolomide for intracranial glioblastoma after convection-enhanced delivery. ⁶¹ ⁵⁴	Hadjipanayis CG...Deluca NA	18728637	2008
23	Herpes simplex virus type 1 Us3 gene deletion influences toll-like receptor responses in cultured monocytic cells. ⁶¹ ⁵⁴	Peri P...Hukkanen V	19025601	2008
24	Herpes simplex virus downregulates secretory leukocyte protease inhibitor: a novel immune evasion mechanism. ⁵⁴ ⁶¹	Fakioglu E...Herold BC	18667508	2008
25	STAT-1- and IRF-3-dependent pathways are not essential for repression of ICP0-null mutant herpes simplex virus type 1 in human fibroblasts. ⁵⁴ ⁶¹	Everett RD...Orr A	18579584	2008
26	HVEM and nectin-1 are the major mediators of herpes simplex virus 1 (HSV-1) entry into human conjunctival epithelium. ⁶¹ ⁵⁴	Akhtar J...Shukla D	18502984	2008
27	Gender-dependent HLA-DR-restricted epitopes identified from herpes simplex virus type 1 glycoprotein D. ⁶¹ ⁵⁴	Zhang X...BenMohamed L	18667634	2008
28	Herpes simplex virus type 1 ICP27 regulates expression of a variant, secreted form of glycoprotein C by an intron retention mechanism. ⁶¹ ⁵⁴	Sedlackova L...Rice SA	18495765	2008
29	Effect of conjugation with polypeptide carrier on the enzymatic degradation of Herpes simplex virus glycoprotein D derived epitope peptide. ⁵⁴ ⁶¹	Tugyi R...Hudecz F	18651758	2008
30	Blocking antibody access to neutralizing domains on glycoproteins involved in entry as a novel mechanism of immune evasion by herpes simplex virus type 1 glycoproteins C and E. ⁵⁴ ⁶¹	Hook LM...Friedman HM	18480440	2008
31	Uracil-DNA glycosylase (UNG) influences the melting temperature (T(m)) of herpes simplex virus (HSV) hybridization probes. ⁵⁴ ⁶¹	Leblanc JJ...Hatchette TF	18468698	2008
32	NADPH oxidase activation is required for migration by LIGHT in human monocytes. ⁵⁴ ⁶¹	Heo SK...Park SD	18468509	2008
33	Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boost CD8 T-cell responses in HSV-naïve and HSV-2-infected subjects. ⁶¹ ⁵⁴	Koelle DM...Wald A	18353920	2008
34	High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity. ⁵⁴ ⁶¹	King GD...Castro MG	18287240	2008
35	Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100. ⁵⁴ ⁶¹	Everett RD...Orr A	18160441	2008
36	The herpes simplex virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein D. ⁶¹ ⁵⁴	Stiles KM...Krummenacher C	18076965	2008
37	Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses. ⁵⁴ ⁶¹	Lasaro MO...Ertl HC	18193057	2008
38	Characterization and susceptibility to antiviral agents of herpes simplex virus type 1 containing a unique thymidine kinase gene with an amber codon between the first and the second initiation codons. ⁶¹ ⁵⁴	Saijo M...Morikawa S	18066636	2008
39	The role of herpes simplex virus-1 thymidine kinase alanine 168 in substrate specificity. ⁶¹ ⁵⁴	Candice L W...Margaret E B	18949076	2008
40	Inhibitory oligodeoxynucleotides downregulate herpes simplex virus-induced plasmacytoid dendritic cell type I interferon production and modulate cell function. ⁵⁴ ⁶¹	Peng WM...Novak N	18082566	2007
41	Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion. ⁶¹ ⁵⁴	Atanasiu D...Eisenberg RJ	18003913	2007
42	Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein. ⁵⁴ ⁶¹	Avitabile E...Campadelli-Fiume G	17670828	2007
43	Antitumor effects of non-replicative herpes simplex vectors expressing antiangiogenic proteins and thymidine kinase on Lewis lung carcinoma establishment and growth. ⁵⁴ ⁶¹	Berto E...Marconi P	17557110	2007
44	Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia. ⁵⁴ ⁶¹	Wang K...Straus SE	17459924	2007
45	Alternative entry receptors for herpes simplex virus and their roles in disease. ⁶¹ ⁵⁴	Taylor JM...Spear PG	18005714	2007
46	Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector. ⁵⁴ ⁶¹	Kummer C...Jacobs AH	17532884	2007
47	Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta. ⁶¹ ⁵⁴	Prabhakar S...Breakefield XO	17304235	2007
48	Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein. ⁶¹ ⁵⁴	Sanchez R...Mohr I	17229694	2007
49	Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B. ⁶¹ ⁵⁴	Subramanian RP...Geraghty RJ	17299053	2007
50	Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0. ⁵⁴ ⁶¹	Lomonte P...Morency E	17258208	2007

Sources

Genes for Herpes Simplex

Genes related to Herpes Simplex (0 elite genes):

(show top 50) (show all 52)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NECTIN1	Nectin Cell Adhesion Molecule 1	Protein Coding	73.97	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Summaries Proteins Pathways & Interactions Functions (show sections)	9861033 12915538 12885915 (more) 15731277 10482562 11836420 18502984 11544254 20455098 20089288 12915568 19129446 17005657 14963155 15972328 11531408 11483743 11437670 15534229 11069980 19521665 18005714 10627537 15273289 18803666
2	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	62.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries Proteins Pathways & Interactions Functions (show sections)	11119586 9657005 19915044 (more) 11511354 18005714 12915568 12915538 11164894 19426226 12368332 12466117 18502984
3	HCFC1	Host Cell Factor C1	Protein Coding	60.72	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries Proteins Pathways & Interactions Functions (show sections)	12456665 16042417 12271126 (more) 15190068 12670868 1684335 10637318 17698583 16282471 11711630 9223485 16633736 12743030 9334261 20126307 19016376 18520591 12244100 15705566 10871379 10629049 10196288 8392914 10398682 10984507 9123865 10958670 14532282 8454622 12235138
4	NECTIN2	Nectin Cell Adhesion Molecule 2	Protein Coding	50.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries Proteins Functions (show sections)	12915538 11602758 12915581
5	TLR3	Toll Like Receptor 3	Protein Coding	50.65	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Pathways & Interactions Variants (show sections)	19025601 16847112
6	UNC93B1	Unc-93 Homolog B1, TLR Signaling Regulator	Protein Coding	46.32	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
7	POU2F1	POU Class 2 Homeobox 1	Protein Coding	45.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)	1684335 1358755 7568211 (more) 7891704 16282471 1406672 8284200 10398682 12271126 7642649 8441632 1645782 9315674
8	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	44.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)	16414988 9765401 9223497 (more) 9023344 11773369 9696792 12414939 17229694 11070019 15174900
9	PML	PML Nuclear Body Scaffold	Protein Coding	44.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)	19279115 10574707 10233977 (more) 9151854 12186918 12610143 9658103 11485412 11602710
10	TBK1	TANK Binding Kinase 1	Protein Coding	41.03	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Proteins Pathways & Interactions (show sections)
11	IFI16	Interferon Gamma Inducible Protein 16	Protein Coding	40	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions localization (show sections)
12	PILRA	Paired Immunoglobin Like Type 2 Receptor Alpha	Protein Coding	39.03	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
13	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	37.12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
14	IRF3	Interferon Regulatory Factor 3	Protein Coding	37.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)	12917470 17215277 16603509
15	TICAM1	Toll Like Receptor Adaptor Molecule 1	Protein Coding	34.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)
16	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	33.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Pathways & Interactions Variants (show sections)
17	TAP2	Transporter 2, ATP Binding Cassette Subfamily B Member	Protein Coding	33.11	GeneCards inferred via : Publications Proteins Pathways & Interactions Functions (show sections)
18	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	31.54	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries Functions (show sections)	9271389 10871379
19	DDX58	DExD/H-Box Helicase 58	Protein Coding	31.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
20	IFNA1	Interferon Alpha 1	Protein Coding	30.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	1719612 2153279 2158516 (more) 1379288 7852835 8863993 13130472 14969765 15320906 15622449 2172409 7697520 8724854 10652752 11836673 2168998 2264889 1719613 1331251 8031058 8380210 8181190 7855636 8578993 9139085 9637497 9707372 11482999 15727684 12687260 11544466 9335431 8887056 8830796 8709261 1666118 1695643 18653740 15163721 14963171 12893749 9802930 12209136 12738374 16000865 8103535 8027590 8091644 8711430 14742635 11927638 12224508 12845770 15753256 16603509 1883515 11488639 11689663 1655906
21	HCFC2	Host Cell Factor C2	Protein Coding	30.38	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries Pathways & Interactions (show sections)
22	CGAS	Cyclic GMP-AMP Synthase	Protein Coding	30.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
23	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	30.28	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
24	CASP8	Caspase 8	Protein Coding	30.2	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
25	C3	Complement C3	Protein Coding	29.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
26	CD209	CD209 Molecule	Protein Coding	29.47	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions (show sections)
27	OAS1	2'-5'-Oligoadenylate Synthetase 1	Protein Coding	29.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Pathways & Interactions Functions (show sections)
28	STING1	Stimulator Of Interferon Response CGAMP Interactor 1	Protein Coding	29.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
29	HS3ST3B1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1	Protein Coding	28.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries Functions (show sections)
30	IFNB1	Interferon Beta 1	Protein Coding	28.57	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	11883188 16439992 16603509 (more) 1666118 15727684 9335431 14963171 1463323
31	SP100	SP100 Nuclear Antigen	Protein Coding	28.2	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	18160441 19279115
32	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	27.98	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
33	TLR9	Toll Like Receptor 9	Protein Coding	27.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19755019 17085599 19025601 (more) 18082566 11927638 16847112
34	ITGAV	Integrin Subunit Alpha V	Protein Coding	27.38	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Functions (show sections)
35	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	27.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins Pathways & Interactions (show sections)
36	GTF2B	General Transcription Factor IIB	Protein Coding	25.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Proteins (show sections)	14764096 7791769 8972203 (more) 11371188 8392607 10449590 15081896
37	ACKR1	Atypical Chemokine Receptor 1 (Duffy Blood Group)	Protein Coding	25.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8388365 12021353 7911177 (more) 12885915 14556904 9696802 9837796 12225814 15016549 18468509 18573279 7576569 9346834 11119586 10627537 7490454 7572464 1780614 1645898 15619895 17299053 15273289 17164784 16213178 12381352 9684378 9525660 1667262 16221064 16044540 7494331 9879759 7745699 18651758 18076965 11090178 19386594 18667634 16288376 15534229 18723002 18193057 12417744 11394975 10225292 10559300 15546385 12915581 12915568 12829851 12504254 12537725 8278393 20089288 8038227 1652468 1713774 2164044 19702506 16131544 12692272 11851316 8585768 8133093 18671825 15864815 14711338 10482637 11162814
38	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	25.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	9696792 9023344 11070019 (more) 15705855 9765401 11773369 9223497 10074192
39	TNFSF14	TNF Superfamily Member 14	Protein Coding	25.73	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	12466117 12566458 15814693 (more) 16131544 15115612 19426226 18412315 15546385 17010447 12651068 16275888
40	POU2F2	POU Class 2 Homeobox 2	Protein Coding	25.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	8129727 8645173 7733899
41	DAXX	Death Domain Associated Protein	Protein Coding	25.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	16603511
42	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	24.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	11517395
43	TLR2	Toll Like Receptor 2	Protein Coding	24.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19755019 17085599 17522215 (more) 16188968 15688290 19078985 19025601
44	RNASEL	Ribonuclease L	Protein Coding	24.68	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19042034 17205688
45	TBP	TATA-Box Binding Protein	Protein Coding	24.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Proteins (show sections)	8798634 7479838 15081896
46	IRF7	Interferon Regulatory Factor 7	Protein Coding	23.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	17215277
47	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	23.73	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	18579584
48	GYPC	Glycophorin C (Gerbich Blood Group)	Protein Coding	23.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8887056 10666258 16140775 (more) 18480440 1645168 10774198 1647772 1462119 19186100 1382102 8289387 17035313 9037375 11160692 9620988
49	CD8A	CD8a Molecule	Protein Coding	23.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Expressions (show sections)
50	TNF	Tumor Necrosis Factor	Protein Coding	22.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Pathways & Interactions (show sections)

Sources

Variations for Herpes Simplex

Sources

Expression for Herpes Simplex

Genes differentially expressed in tissues of Herpes Simplex patients vs. healthy controls: ³⁵

#	Gene	Description	Tissue	Up/Dn	Fold Change (log2)	P value
1	FCN1	ficolin (collagen/fibrinogen domain containing) 1	Skin	+	3.89	0.000
2	IRF1	interferon regulatory factor 1	Skin	+	3.58	0.000
3	STAT1	signal transducer and activator of transcription 1, 91kDa	Skin	+	3.53	0.000
4	RARRES3	retinoic acid receptor responder (tazarotene induced) 3	Skin	+	3.49	0.000
5	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	Skin	+	3.41	0.000
6	CCL19	chemokine (C-C motif) ligand 19	Skin	+	3.32	0.003
7	XAF1	XIAP associated factor 1	Skin	+	3.04	0.000

Search GEO for disease gene expression data for Herpes Simplex.

Sources

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.82	UNC93B1 TRAF3 TNFRSF14 TLR3 TICAM1 TBK1
2	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.24	TRAF3 TNFRSF14 POU2F1 PML IRF3 IFNA1
3	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.91	TRAF3 TLR3 TICAM1 TBK1 IRF3 IFNA1
4	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.89	TRAF3 TLR3 TICAM1 TBK1 IRF3 IFNA1
5	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.75	TRAF3 TLR3 TICAM1 TBK1 TAP2 TAP1
6	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²² Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²² NOD-like Receptor Signaling Pathways ⁶⁴	12.61	TRAF3 TLR3 TICAM1 TBK1 IRF3 IFNA1
7	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.6	TRAF3 TLR3 TICAM1 TBK1 TAP2 TAP1
8	4-1BB Pathway ⁶³ Show member pathways CD27 Pathway ⁶³ CD40 Signaling ⁶³ CMV and MAPK Pathways ⁶³ NF-KappaB Activation by EBV ⁶³ NF-kappaB Activation by Viruses ⁶³ PKR Pathway ⁶³ SUMO Pathway ⁶³ TNFR2 Pathway ⁶³	12.56	TRAF3 TBK1 PML EIF2AK2 CREB3
9	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁵ Show member pathways Negative regulators of RIG-I/MDA5 signaling ⁶⁵ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁵ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁶ TRAF3-dependent IRF activation pathway ⁶⁵ TRAF6 mediated IRF7 activation ⁶⁵	12.45	TRAF3 TBK1 IRF3 IFNA1 DDX58
10	Cytosolic sensors of pathogen-associated DNA ⁶⁵ Show member pathways Cytosolic DNA-sensing pathway ³⁶ DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁵ IkBA variant leads to EDA-ID ⁶⁵ IKBKB deficiency causes SCID ⁶⁵ IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) ⁶⁵ IRF3 mediated activation of type 1 IFN ⁶⁵ IRF3-mediated induction of type I IFN ⁶⁵ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁵ Regulation by TREX1 ⁶⁵ Regulation of innate immune responses to cytosolic DNA ⁶⁵ RIP-mediated NFkB activation via ZBP1 ⁶⁵ STAT6-mediated induction of chemokines ⁶⁵ STING mediated induction of host immune responses ⁶⁵ TAK1 activates NFkB by phosphorylation and activation of IKKs complex ⁶⁵ TRAF6 mediated NF-kB activation ⁶⁵ ZBP1(DAI) mediated induction of type I IFNs ⁶⁵	12.45	TLR3 TICAM1 TBK1 IRF3 IFNA1 IFI16
11	Interferon gamma signaling ⁶⁵ Show member pathways Interferon Signaling ⁶⁵ Regulation of IFNG signaling ⁶⁵	12.44	PML IRF3 IFNA1 EIF2AK2 DDX58
12	VEGF Pathway (Qiagen) ⁶³ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁵ VEGF Pathway ⁶³	12.31	TLR3 TICAM1 TBK1 IRF3 CREB3
13	Herpes simplex virus 1 infection ³⁶	12.22	TRAF3 TNFRSF14 TLR3 TICAM1 TBK1 TAP2
14	Viral carcinogenesis ³⁶	12.19	TRAF3 IRF3 EIF2AK2 CREB3
15	NOD-like receptor signaling pathway ³⁶	12.17	TRAF3 TICAM1 TBK1 IRF3 IFNA1 IFI16
16	NF-kappaB Signaling ⁴	12.17	TRAF3 TLR3 TICAM1 TBK1 TAP2 TAP1
17	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.15	TRAF3 TLR3 TICAM1 TBK1 IRF3
18	Necroptosis ³⁶ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.11	TLR3 TICAM1 IFNA1 EIF2AK2
19	Yersinia infection ³⁶	11.86	TICAM1 TBK1 IRF3
20	NF-kappa B signaling pathway ³⁶	11.79	TRAF3 TICAM1 DDX58
21	NF-kB(NFkB) Pathway ⁶⁶	11.77	TRAF3 TICAM1 TBK1
22	Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶⁰ Show member pathways Inhibition of PKR ⁶⁵	11.05	IRF3 EIF2AK2 DDX58

Sources

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum	GO:0005783	9.8	UNC93B1 TLR3 TAP2 TAP1 POU2F1 PML
2	endoplasmic reticulum membrane	GO:0005789	9.63	UNC93B1 TLR3 TAP2 TAP1 PML CREB3
3	MHC class I peptide loading complex	GO:0042824	8.96	TAP2 TAP1
4	TAP complex	GO:0042825	8.62	TAP2 TAP1

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 36)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.17	TLR3 TBK1 POU2F1 IRF3 IFI16 DDX58
2	adaptive immune response	GO:0002250	10.03	UNC93B1 TNFRSF14 TAP2 TAP1 IFNA1
3	innate immune response	GO:0045087	10	UNC93B1 TRAF3 TNFRSF14 TLR3 TICAM1 TBK1
4	immune system process	GO:0002376	9.97	UNC93B1 TRAF3 TNFRSF14 TLR3 TICAM1 TBK1
5	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.91	TLR3 TICAM1 TBK1 IRF3
6	response to virus	GO:0009615	9.84	TLR3 TBK1 EIF2AK2 DDX58
7	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.8	TLR3 TICAM1 TBK1
8	positive regulation of type I interferon production	GO:0032481	9.8	TLR3 TICAM1 TBK1 IRF3 IFI16
9	positive regulation of interleukin-6 production	GO:0032755	9.78	TLR3 TICAM1 DDX58
10	response to exogenous dsRNA	GO:0043330	9.77	TLR3 TICAM1 IRF3 IFNA1 DDX58
11	toll-like receptor signaling pathway	GO:0002224	9.74	UNC93B1 TRAF3 TLR3
12	positive regulation of cytokine production	GO:0001819	9.73	TLR3 IFI16 EIF2AK2
13	positive regulation of interferon-beta production	GO:0032728	9.73	TLR3 TBK1 IRF3 DDX58
14	negative regulation of type I interferon production	GO:0032480	9.72	TBK1 IRF3 DDX58
15	TRIF-dependent toll-like receptor signaling pathway	GO:0035666	9.72	TRAF3 TLR3 TICAM1 TBK1 IRF3
16	cellular response to exogenous dsRNA	GO:0071360	9.69	TLR3 IRF3 DDX58
17	necroptotic process	GO:0070266	9.67	TLR3 TICAM1
18	regulation of protein complex assembly	GO:0043254	9.67	TICAM1 HCFC1
19	positive regulation of interferon-alpha production	GO:0032727	9.67	TBK1 IRF3 DDX58
20	positive regulation of chemokine production	GO:0032722	9.66	TLR3 EIF2AK2
21	MyD88-independent toll-like receptor signaling pathway	GO:0002756	9.66	TLR3 TICAM1
22	regulation of type I interferon production	GO:0032479	9.65	TBK1 IRF3
23	positive regulation of type I interferon-mediated signaling pathway	GO:0060340	9.65	TBK1 IRF3
24	positive regulation of chemokine biosynthetic process	GO:0045080	9.65	TLR3 TICAM1
25	toll-like receptor 3 signaling pathway	GO:0034138	9.65	UNC93B1 TLR3 TICAM1
26	defense response to virus	GO:0051607	9.65	UNC93B1 TLR3 TICAM1 TBK1 PML IRF3
27	peptide transport	GO:0015833	9.64	TAP2 TAP1
28	antigen processing and presentation of endogenous peptide antigen via MHC class I	GO:0019885	9.64	TAP2 TAP1
29	positive regulation of interferon-beta biosynthetic process	GO:0045359	9.63	TLR3 TICAM1 TBK1
30	negative regulation of MyD88-independent toll-like receptor signaling pathway	GO:0034128	9.62	TLR3 TICAM1
31	vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	GO:1990668	9.6	TAP2 TAP1
32	detection of virus	GO:0009597	9.59	TLR3 DDX58
33	positive regulation of myeloid dendritic cell cytokine production	GO:0002735	9.58	TICAM1 DDX58
34	virion attachment to host cell	GO:0019062	9.58	NECTIN2 NECTIN1
35	cytosol to ER transport	GO:0046967	9.52	TAP2 TAP1
36	viral process	GO:0016032	9.47	TNFRSF14 TICAM1 TBK1 TAP2 TAP1 PML

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:0042803	9.93	TAP1 PML NECTIN2 NECTIN1 IRF3
2	protein binding	GO:0005515	9.93	UNC93B1 TRAF3 TNFRSF14 TLR3 TICAM1 TBK1
3	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.92	POU2F1 IRF3 IFI16 HCFC1 CREB3
4	ubiquitin protein ligase binding	GO:0031625	9.81	TRAF3 TNFRSF14 PML DDX58
5	identical protein binding	GO:0042802	9.76	TLR3 TBK1 NECTIN2 NECTIN1 IRF3 HCFC1
6	virus receptor activity	GO:0001618	9.65	TNFRSF14 NECTIN2 NECTIN1
7	double-stranded RNA binding	GO:0003725	9.61	TLR3 EIF2AK2 DDX58
8	MHC protein binding	GO:0042287	9.49	TAP2 TAP1
9	peptide transmembrane transporter activity	GO:1904680	9.46	TAP2 TAP1
10	TAP1 binding	GO:0046978	9.4	TAP2 TAP1
11	MHC class Ib protein binding	GO:0023029	9.37	TAP2 TAP1
12	peptide antigen-transporting ATPase activity	GO:0015433	9.32	TAP2 TAP1
13	peptide-transporting ATPase activity	GO:0015440	9.26	TAP2 TAP1
14	MHC class I protein binding	GO:0042288	8.8	TAP2 TAP1 PILRA

Sources

Sources for Herpes Simplex

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Herpes Simplex

Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Classifications:

External Ids:

Summaries for Herpes Simplex

Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Herpes Simplex:

Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Herpes Simplex:

Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: herpes simplex

Genetic Tests for Herpes Simplex

Anatomical Context for Herpes Simplex

The Foundational Model of Anatomy Ontology organs/tissues related to Herpes Simplex:

MalaCards organs/tissues related to Herpes Simplex:

Publications for Herpes Simplex

Articles related to Herpes Simplex:

Genes for Herpes Simplex

Genes related to Herpes Simplex (0 elite genes):

Variations for Herpes Simplex

Expression for Herpes Simplex

Pathways for Herpes Simplex

Pathways related to Herpes Simplex according to GeneCards Suite gene sharing:

GO Terms for Herpes Simplex

Cellular components related to Herpes Simplex according to GeneCards Suite gene sharing:

Biological processes related to Herpes Simplex according to GeneCards Suite gene sharing:

Molecular functions related to Herpes Simplex according to GeneCards Suite gene sharing:

Sources for Herpes Simplex

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :