MCID: HRP006
MIFTS: 71

Herpes Simplex

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Herpes Simplex

MalaCards integrated aliases for Herpes Simplex:

Name: Herpes Simplex 12 56 44 45 15
Herpesvirus Hominis Disease 12
Herpes Simplex Infections 74
Herpes Simplex Disease 77

Classifications:



External Ids:

Disease Ontology 12 DOID:8566
ICD9CM 36 054
MeSH 45 D006561
SNOMED-CT 69 88594005
ICD10 34 B00 B00.9
UMLS 74 C0019348

Summaries for Herpes Simplex

MedlinePlus : 44 Herpes is an infection that is caused by a herpes simplex virus (HSV). Oral herpes causes cold sores around the mouth or face. Genital herpes affects the genitals, buttocks or anal area. Genital herpes is a sexually transmitted disease (STD). It affects the genitals, buttocks or anal area. Other herpes infections can affect the eyes, skin, or other parts of the body. The virus can be dangerous in newborn babies or in people with weak immune systems. There are two types of HSV: HSV type 1 most commonly causes cold sores. It can also cause genital herpes. HSV type 2 is the usual cause of genital herpes, but it also can infect the mouth. HSV spreads through direct contact. Some people have no symptoms. Others get sores near the area where the virus has entered the body. They turn into blisters, become itchy and painful, and then heal. Most people have outbreaks several times a year. Over time, you get them less often. Medicines to help your body fight the virus can help lessen symptoms and decrease outbreaks.

MalaCards based summary : Herpes Simplex, also known as herpesvirus hominis disease, is related to herpes simplex encephalitis and acute retinal necrosis syndrome, and has symptoms including fever, pruritus and snoring. An important gene associated with Herpes Simplex is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Docosanol and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and brain, and related phenotypes are no effect and Decreased viability

Disease Ontology : 12 A viral infectious disease that results in_formation_of lesions, located in mouth, located in face, located in genitalia, or located in hands, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which are transmitted by direct contact with an active lesion or body fluid of an infected person.

Wikipedia : 77 Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomical names Human... more...

Related Diseases for Herpes Simplex

Diseases in the Herpes Simplex family:

Congenital Herpes Simplex

Diseases related to Herpes Simplex via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 707, show less)
# Related Disease Score Top Affiliating Genes
1 herpes simplex encephalitis 34.6 IRF3 TBK1 TICAM1 TLR3 TRAF3 UNC93B1
2 acute retinal necrosis syndrome 32.7 NECTIN1 TNFRSF14
3 encephalitis 32.1 DDX58 IRF3 TICAM1 TLR3 TRAF3 UNC93B1
4 rabies 30.6 IRF3 PML TLR3
5 influenza 30.5 DDX58 EIF2AK2 IRF3 PML TLR3
6 hepatitis c 30.5 DDX58 EIF2AK2 IRF3 TLR3
7 measles 30.4 DDX58 EIF2AK2 TLR3
8 west nile virus 30.0 DDX58 IRF3 TLR3
9 noonan syndrome 3 30.0 DDX58 IRF3 TBK1 TLR3
10 herpes simplex virus keratitis 12.7
11 congenital herpes simplex virus infection 12.6
12 congenital herpes simplex 12.5
13 eczema herpeticum 12.5
14 encephalopathy, acute, infection-induced 2 12.4
15 encephalopathy, acute, infection-induced 1 12.4
16 genital herpes 12.2
17 encephalopathy, acute, infection-induced 8 12.2
18 encephalopathy, acute, infection-induced 5 12.0
19 encephalopathy, acute, infection-induced 6 12.0
20 encephalopathy, acute, infection-induced 7 12.0
21 neonatal herpes 11.9
22 herpetic whitlow 11.7
23 mollaret meningitis 11.7
24 erythema multiforme 11.6
25 cytomegalovirus infection 11.6
26 proctitis 11.6
27 viral pneumonia 11.5
28 aphthous stomatitis 11.5
29 cytomegalic inclusion disease 11.5
30 immunodeficiency 31a 11.5
31 hyper-ige recurrent infection syndrome 2, autosomal recessive 11.2
32 caspase 8 deficiency 11.2
33 salivary gland disease 11.2
34 pseudomembranous conjunctivitis 11.2
35 herpetic gastritis 11.2
36 congenital intrauterine infection-like syndrome 11.2
37 pudendal neuralgia 11.2
38 recessive dystrophic epidermolysis bullosa-generalized other 11.2
39 torch syndrome 11.2
40 neurological consequences of cytomegalovirus infection 11.2
41 keratitis, hereditary 10.9
42 chickenpox 10.8
43 hepatitis 10.7
44 meningitis 10.6
45 stromal keratitis 10.6
46 esophagitis 10.6
47 blood group, gerbich system 10.6
48 glioma 10.5
49 bell's palsy 10.5
50 acute liver failure 10.5
51 leukemia 10.5
52 alzheimer disease 10.5
53 myelitis 10.5
54 acquired immunodeficiency syndrome 10.5
55 stomatitis 10.5
56 human immunodeficiency virus type 1 10.5
57 meningoencephalitis 10.5
58 glioblastoma 10.5
59 chlamydia 10.5
60 pneumonia 10.5
61 herpes zoster 10.5
62 facial paralysis 10.4
63 retinitis 10.4
64 syphilis 10.4
65 suppressor of tumorigenicity 3 10.4
66 infantile liver failure syndrome 1 10.4
67 pemphigus 10.4
68 lymphoma 10.4
69 malignant glioma 10.4
70 uveitis 10.4
71 idiopathic recurrent and disabling cutaneous herpes 10.4
72 pemphigus vulgaris, familial 10.4
73 pemphigus vulgaris 10.4
74 lymphadenitis 10.4
75 rubella 10.4
76 anterior uveitis 10.4
77 cleft lip/palate-ectodermal dysplasia syndrome 10.4 NECTIN1 NECTIN2 TNFRSF14
78 papilloma 10.3
79 blood group--ul system 10.3
80 breast cancer 10.3
81 lymphocytic leukemia 10.3
82 dermatitis 10.3
83 vaccinia 10.3
84 prostate cancer 10.3
85 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.3
86 aseptic meningitis 10.3
87 squamous cell carcinoma 10.3
88 epilepsy 10.3
89 leukemia, chronic lymphocytic 2 10.3
90 hepatocellular carcinoma 10.3
91 leukemia, chronic lymphocytic 10.3
92 lung cancer 10.3
93 xeroderma pigmentosum, variant type 10.3
94 mumps 10.3
95 melanoma 10.3
96 cervicitis 10.3
97 viral encephalitis 10.3
98 keratoconjunctivitis 10.3
99 leukemia, b-cell, chronic 10.3
100 multiple sclerosis 10.3
101 prostate cancer, hereditary, 8 10.3
102 prostate cancer, hereditary, 6 10.3
103 hematopoietic stem cell transplantation 10.3
104 hemophagocytic lymphohistiocytosis 10.3
105 mucositis 10.3
106 corneal disease 10.3
107 squamous cell papilloma 10.3
108 glioblastoma multiforme 10.3
109 trigeminal neuralgia 10.2
110 cervical cancer 10.2
111 graft-versus-host disease 10.2
112 immunodeficiency by defective expression of hla class 1 10.2 TAP1 TAP2
113 ovarian cancer 10.2
114 schizophrenia 10.2
115 amnestic disorder 10.2
116 bacterial vaginosis 10.2
117 human immunodeficiency virus infectious disease 10.2
118 molluscum contagiosum 10.2
119 endotheliitis 10.2
120 glioma susceptibility 1 10.2
121 wiskott-aldrich syndrome 10.2
122 cataract 10.2
123 crohn's disease 10.2
124 chlamydia pneumonia 10.2
125 variola major 10.2
126 colitis 10.2
127 sarcoma 10.2
128 iritis 10.2
129 blepharoconjunctivitis 10.2
130 kluver-bucy syndrome 10.2
131 conjunctivitis 10.2
132 smallpox 10.2
133 iridocyclitis 10.2
134 blepharitis 10.2
135 viral infectious disease 10.2 DDX58 EIF2AK2 IRF3 TBK1 TLR3
136 esophageal cancer 10.2
137 small cell cancer of the lung 10.2
138 autism 10.2
139 severe cutaneous adverse reaction 10.2
140 severe combined immunodeficiency 10.2
141 cystitis 10.2
142 thyroid cancer 10.2
143 neuritis 10.2
144 adenocarcinoma 10.2
145 central nervous system disease 10.2
146 combined t cell and b cell immunodeficiency 10.2
147 acute disseminated encephalomyelitis 10.2
148 peptic ulcer disease 10.2
149 chorioretinitis 10.2
150 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.2
151 noonan syndrome 1 10.1 DDX58 IRF3 TBK1 TLR3
152 burkitt lymphoma 10.1
153 kaposi sarcoma 10.1
154 systemic lupus erythematosus 10.1
155 incontinentia pigmenti 10.1
156 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
157 arthritis 10.1
158 hepatitis b 10.1
159 laryngotracheitis 10.1
160 sensorineural hearing loss 10.1
161 japanese encephalitis 10.1
162 hepatitis a 10.1
163 urethritis 10.1
164 candidiasis 10.1
165 laryngitis 10.1
166 t-cell leukemia 10.1
167 myocarditis 10.1
168 bullous pemphigoid 10.1
169 nervous system disease 10.1
170 neuropathy 10.1
171 lupus erythematosus 10.1
172 cervical intraepithelial neoplasia 10.1
173 ige responsiveness, atopic 10.1
174 thyroid carcinoma, familial medullary 10.1
175 medulloblastoma 10.1
176 rheumatoid arthritis 10.1
177 ataxia-telangiectasia 10.1
178 pancreatic cancer 10.1
179 thymoma, familial 10.1
180 dermatitis, atopic 10.1
181 hepatitis c virus 10.1
182 esophagitis, eosinophilic, 1 10.1
183 human herpesvirus 8 10.1
184 burns 10.1
185 common variable immunodeficiency 10.1
186 keratopathy 10.1
187 spinal cord injury 10.1
188 ulcerative colitis 10.1
189 tick-borne encephalitis 10.1
190 hemorrhagic cystitis 10.1
191 cutaneous t cell lymphoma 10.1
192 endometritis 10.1
193 asymptomatic neurosyphilis 10.1
194 viral meningitis 10.1
195 duodenal ulcer 10.1
196 status epilepticus 10.1
197 viral hepatitis 10.1
198 vaginitis 10.1
199 demyelinating disease 10.1
200 rhabdomyosarcoma 10.1
201 ischemia 10.1
202 thymoma 10.1
203 purpura 10.1
204 vulvitis 10.1
205 pyoderma 10.1
206 corneal ulcer 10.1
207 pyoderma gangrenosum 10.1
208 vasculitis 10.1
209 lichen planus 10.1
210 toxoplasmosis 10.1
211 acute graft versus host disease 10.1
212 bowenoid papulosis 10.1
213 iridocorneal endothelial syndrome 10.1
214 neurosyphilis 10.1
215 sudden sensorineural hearing loss 10.1
216 transverse myelitis 10.1
217 tuberculous meningitis 10.1
218 fixed drug eruption 10.1
219 pfeiffer syndrome 10.0
220 colorectal cancer 10.0
221 melanoma, uveal 10.0
222 meniere disease 10.0
223 pityriasis rubra pilaris 10.0
224 retinoblastoma 10.0
225 thrombocytopenic purpura, autoimmune 10.0
226 mycosis fungoides 10.0
227 myeloma, multiple 10.0
228 testicular regression syndrome 10.0
229 acute hemorrhagic leukoencephalitis 10.0
230 nasopharyngeal carcinoma 10.0
231 meningioma, familial 10.0
232 cholangiocarcinoma 10.0
233 lymphatic malformation 7 10.0
234 adult respiratory distress syndrome 10.0
235 adult t-cell leukemia 10.0
236 hydrocephalus 10.0
237 pelvic inflammatory disease 10.0
238 tonsillitis 10.0
239 spinal meningioma 10.0
240 acoustic neuroma 10.0
241 telangiectasis 10.0
242 dementia 10.0
243 norwegian scabies 10.0
244 trichomoniasis 10.0
245 pharyngitis 10.0
246 orchitis 10.0
247 agammaglobulinemia 10.0
248 newcastle disease 10.0
249 astrocytoma 10.0
250 gliosarcoma 10.0
251 secretory meningioma 10.0
252 endophthalmitis 10.0
253 benign ependymoma 10.0
254 scabies 10.0
255 impetigo 10.0
256 in situ carcinoma 10.0
257 psoriasis 10.0
258 diabetes insipidus 10.0
259 yellow fever 10.0
260 acanthamoeba keratitis 10.0
261 allergic encephalomyelitis 10.0
262 autoimmune encephalitis 10.0
263 cluster headache 10.0
264 cytokine deficiency 10.0
265 ependymoma 10.0
266 fetal edema 10.0
267 hydrops fetalis 10.0
268 polymyositis 10.0
269 sutton disease 2 10.0
270 hypoxia 10.0
271 dysphagia 10.0
272 encephalopathy 10.0
273 headache 10.0
274 neurofibromatosis, type ii 9.9
275 bladder cancer 9.9
276 blood group, colton system 9.9
277 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.9
278 creutzfeldt-jakob disease 9.9
279 renal cell carcinoma, nonpapillary 9.9
280 cholestasis, intrahepatic, of pregnancy, 1 9.9
281 leiomyoma, uterine 9.9
282 mesothelioma, malignant 9.9
283 neutrophil migration 9.9
284 benign chronic pemphigus 9.9
285 thrombophilia due to thrombin defect 9.9
286 chondrosarcoma 9.9
287 hydrocephalus, congenital, 1 9.9
288 mucopolysaccharidosis, type vii 9.9
289 neuroblastoma 1 9.9
290 periodontitis, chronic 9.9
291 scapuloperoneal myopathy, x-linked dominant 9.9
292 aging 9.9
293 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 9.9
294 suppression of tumorigenicity 12 9.9
295 kawasaki disease 9.9
296 leukemia, acute lymphoblastic 9.9
297 gastric cancer 9.9
298 immunodeficiency 21 9.9
299 dengue virus 9.9
300 hemorrhage, intracerebral 9.9
301 mucopolysaccharidosis-plus syndrome 9.9
302 acute leukemia 9.9
303 acute lymphocytic leukemia 9.9
304 burn scar 9.9
305 cerebral hemorrhage 9.9
306 keratoconus 9.9
307 neutropenia 9.9
308 autism spectrum disorder 9.9
309 aphasia 9.9
310 thrombosis 9.9
311 cytomegalovirus retinitis 9.9
312 interstitial nephritis 9.9
313 corneal edema 9.9
314 bullous keratopathy 9.9
315 acute conjunctivitis 9.9
316 conjunctival folliculosis 9.9
317 ornithosis 9.9
318 keratomalacia 9.9
319 tetanus 9.9
320 corneal neovascularization 9.9
321 lyme disease 9.9
322 panuveitis 9.9
323 optic neuritis 9.9
324 detrusor sphincter dyssynergia 9.9
325 lymphocytic choriomeningitis 9.9
326 bronchopneumonia 9.9
327 leiomyoma 9.9
328 guillain-barre syndrome 9.9
329 choreatic disease 9.9
330 shipyard eye 9.9
331 transient global amnesia 9.9
332 balanitis 9.9
333 scleritis 9.9
334 chancroid 9.9
335 lymphogranuloma venereum 9.9
336 glossitis 9.9
337 labyrinthitis 9.9
338 urticaria 9.9
339 pericarditis 9.9
340 impotence 9.9
341 neuroma 9.9
342 encephalomalacia 9.9
343 vulva squamous cell carcinoma 9.9
344 bronchiolitis 9.9
345 mammary paget's disease 9.9
346 cervical adenocarcinoma 9.9
347 gastritis 9.9
348 primary syphilis 9.9
349 folliculitis 9.9
350 hydranencephaly 9.9
351 movement disease 9.9
352 intrahepatic cholangiocarcinoma 9.9
353 poliomyelitis 9.9
354 infertility 9.9
355 lymphopenia 9.9
356 cll/sll 9.9
357 progressive multifocal leukoencephalopathy 9.9
358 connective tissue disease 9.9
359 malignant pleural mesothelioma 9.9
360 periodontitis 9.9
361 pityriasis rosea 9.9
362 lymphangitis 9.9
363 glaucomatocyclitic crisis 9.9
364 tracheitis 9.9
365 croup 9.9
366 epididymo-orchitis 9.9
367 congenital syphilis 9.9
368 interstitial keratitis 9.9
369 hypereosinophilic syndrome 9.9
370 acute respiratory distress syndrome 9.9
371 congenital cytomegalovirus 9.9
372 congenital hydrocephalus 9.9
373 haemophilus influenzae 9.9
374 hydroa vacciniforme 9.9
375 limbic encephalitis 9.9
376 meningococcemia 9.9
377 mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 9.9
378 oral cancer 9.9
379 rasmussen encephalitis 9.9
380 semantic dementia 9.9
381 virus associated hemophagocytic syndrome 9.9
382 depression 9.9
383 paresthesia 9.9
384 hemophagocytic syndrome associated with an infection 9.9
385 congenital erosive and vesicular dermatosis 9.9
386 bullous impetigo 9.9
387 autoimmune disease 9.8
388 behcet syndrome 9.8
389 biliary cirrhosis, primary, 1 9.8
390 cleft palate, isolated 9.8
391 darier-white disease 9.8
392 glaucoma, primary open angle 9.8
393 hypophosphatemic bone disease 9.8
394 myoclonus and ataxia 9.8
395 carney complex, type 1 9.8
396 ocular cicatricial pemphigoid 9.8
397 paget disease, extramammary 9.8
398 pelger-huet anomaly 9.8
399 polykaryocytosis inducer 9.8
400 temporal arteritis 9.8
401 achalasia, familial esophageal 9.8
402 chordoma 9.8
403 corneal dystrophy, band-shaped 9.8
404 neuropathy, hereditary sensory and autonomic, type iii 9.8
405 enterocolitis 9.8
406 lymphoma, hodgkin, classic 9.8
407 hydrops fetalis, nonimmune 9.8
408 ichthyosis, congenital, autosomal recessive 4b 9.8
409 myxedema 9.8
410 ocular motor apraxia 9.8
411 orotic aciduria 9.8
412 osteogenic sarcoma 9.8
413 panencephalitis, subacute sclerosing 9.8
414 polycythemia vera 9.8
415 pulmonary alveolar microlithiasis 9.8
416 thrombotic thrombocytopenic purpura, congenital 9.8
417 squamous cell carcinoma, head and neck 9.8
418 lesch-nyhan syndrome 9.8
419 hemophilia b 9.8
420 ataxia and polyneuropathy, adult-onset 9.8
421 asthma 9.8
422 stroke, ischemic 9.8
423 leukemia, acute myeloid 9.8
424 focal segmental glomerulosclerosis 1 9.8
425 caronte 9.8
426 aceruloplasminemia 9.8
427 langerhans cell histiocytosis 9.8
428 lymphoma, non-hodgkin, familial 9.8
429 vitiligo-associated multiple autoimmune disease susceptibility 1 9.8
430 anorexia nervosa 9.8
431 pulmonary disease, chronic obstructive 9.8
432 allergic rhinitis 9.8
433 coronary heart disease 1 9.8
434 ovarian cancer 1 9.8
435 mycobacterium tuberculosis 1 9.8
436 endometrial cancer 9.8
437 myocardial infarction 9.8
438 ichthyosis prematurity syndrome 9.8
439 preterm premature rupture of the membranes 9.8
440 asthma-related traits 4 9.8
441 deafness-infertility syndrome 9.8
442 diabetes mellitus, ketosis-prone 9.8
443 microvascular complications of diabetes 5 9.8
444 premature ovarian failure 7 9.8
445 aspergillosis 9.8
446 takenouchi-kosaki syndrome 9.8
447 nevus comedonicus 9.8
448 helix syndrome 9.8
449 west syndrome 9.8
450 acute lymphoblastic leukemia, childhood 9.8
451 alopecia 9.8
452 alport syndrome 9.8
453 autoimmune hepatitis 9.8
454 bipolar disorder 9.8
455 brain ischemia 9.8
456 bronchiolitis obliterans 9.8
457 dengue disease 9.8
458 diabetic neuropathy 9.8
459 focal segmental glomerulosclerosis 9.8
460 glomerulonephritis 9.8
461 liver cirrhosis 9.8
462 liver disease 9.8
463 lymphedema 9.8
464 male infertility 9.8
465 mantle cell lymphoma 9.8
466 neuromyelitis optica 9.8
467 pancreas adenocarcinoma 9.8
468 pemphigus foliaceus 9.8
469 primary biliary cirrhosis 9.8
470 sinusitis 9.8
471 skin disease 9.8
472 temporal lobe epilepsy 9.8
473 thrombocytopenia 9.8
474 bacterial sepsis 9.8
475 livedoid vasculitis 9.8
476 la crosse encephalitis 9.8
477 cryptogenic organizing pneumonia 9.8
478 autoimmune polyendocrine syndrome type 1 9.8
479 inflammatory bowel disease 9.8
480 funisitis 9.8
481 atrioventricular block 9.8
482 third-degree atrioventricular block 9.8
483 oral squamous cell carcinoma 9.8
484 crohn's colitis 9.8
485 agraphia 9.8
486 atrial fibrillation 9.8
487 meningococcal meningitis 9.8
488 igg4-related disease 9.8
489 optic papillitis 9.8
490 neuroretinitis 9.8
491 louping ill 9.8
492 parotitis 9.8
493 chronic meningitis 9.8
494 chronic leukemia 9.8
495 suppression amblyopia 9.8
496 amblyopia 9.8
497 bacterial infectious disease 9.8
498 perforated corneal ulcer 9.8
499 pre-eclampsia 9.8
500 open-angle glaucoma 9.8
501 mastitis 9.8
502 thrombotic thrombocytopenic purpura 9.8
503 murray valley encephalitis 9.8
504 western equine encephalitis 9.8
505 herpangina 9.8
506 acute salpingitis 9.8
507 q fever 9.8
508 schizophreniform disorder 9.8
509 heart disease 9.8
510 autonomic neuropathy 9.8
511 retinal vasculitis 9.8
512 cicatricial pemphigoid 9.8
513 chronic laryngitis 9.8
514 myopia 9.8
515 ecthyma 9.8
516 conn's syndrome 9.8
517 allergic hypersensitivity disease 9.8
518 cryptococcosis 9.8
519 vaginal disease 9.8
520 pulmonary alveolar proteinosis 9.8
521 viral labyrinthitis 9.8
522 patulous eustachian tube 9.8
523 complex partial epilepsy 9.8
524 posterior uveitis 9.8
525 pyloric stenosis 9.8
526 blastomycosis 9.8
527 vestibular neuronitis 9.8
528 carotid stenosis 9.8
529 branch retinal artery occlusion 9.8
530 central retinal artery occlusion 9.8
531 paronychia 9.8
532 hellp syndrome 9.8
533 megaesophagus 9.8
534 brain cancer 9.8
535 alexia 9.8
536 kwashiorkor 9.8
537 cholestasis 9.8
538 alveolar periostitis 9.8
539 facial neuralgia 9.8
540 sick sinus syndrome 9.8
541 polyneuropathy 9.8
542 amenorrhea 9.8
543 obstructive hydrocephalus 9.8
544 pleuropneumonia 9.8
545 cerebral degeneration 9.8
546 reye syndrome 9.8
547 chronic cervicitis 9.8
548 angioedema 9.8
549 rheumatic disease 9.8
550 keratosis 9.8
551 pneumothorax 9.8
552 ichthyosis 9.8
553 histoplasmosis 9.8
554 cheilitis 9.8
555 calcinosis 9.8
556 mononeuritis multiplex 9.8
557 optic nerve disease 9.8
558 rectum cancer 9.8
559 intestinal perforation 9.8
560 focal epilepsy 9.8
561 vulvovaginitis 9.8
562 dyspepsia 9.8
563 gastroenteritis 9.8
564 colon adenocarcinoma 9.8
565 arteriosclerosis 9.8
566 cystadenoma 9.8
567 transitional cell carcinoma 9.8
568 epidermolysis bullosa 9.8
569 contact dermatitis 9.8
570 cervix carcinoma 9.8
571 acute pancreatitis 9.8
572 pulmonary tuberculosis 9.8
573 cockayne syndrome 9.8
574 iga glomerulonephritis 9.8
575 antiphospholipid syndrome 9.8
576 allergic contact dermatitis 9.8
577 grade iii astrocytoma 9.8
578 gingivitis 9.8
579 gallbladder cancer 9.8
580 oligodendroglioma 9.8
581 neurilemmoma 9.8
582 central nervous system lymphoma 9.8
583 teratocarcinoma 9.8
584 embryonal carcinoma 9.8
585 liposarcoma 9.8
586 periodontal disease 9.8
587 histiocytosis 9.8
588 viral laryngitis 9.8
589 skin carcinoma 9.8
590 cellulitis 9.8
591 lactic acidosis 9.8
592 porokeratosis 9.8
593 cranial nerve palsy 9.8
594 pituitary adenoma 9.8
595 craniopharyngioma 9.8
596 agnosia 9.8
597 anal margin carcinoma 9.8
598 burning mouth syndrome 9.8
599 rhinitis 9.8
600 dysgraphia 9.8
601 nominal aphasia 9.8
602 retrograde amnesia 9.8
603 ludwig's angina 9.8
604 spindle cell hemangioma 9.8
605 pancreatitis 9.8
606 pleural cancer 9.8
607 demyelinating polyneuropathy 9.8
608 acute necrotizing encephalitis 9.8
609 von economo's disease 9.8
610 central nervous system vasculitis 9.8
611 malignant syringoma 9.8
612 retinal disease 9.8
613 salpingitis 9.8
614 peripheral nervous system disease 9.8
615 cerebral lymphoma 9.8
616 esophageal disease 9.8
617 viral esophagitis 9.8
618 clivus chordoma 9.8
619 adenoma 9.8
620 juvenile rheumatoid arthritis 9.8
621 neuronitis 9.8
622 intestinal obstruction 9.8
623 retinal artery occlusion 9.8
624 lung disease 9.8
625 oropharynx cancer 9.8
626 duodenitis 9.8
627 tongue cancer 9.8
628 perinatal necrotizing enterocolitis 9.8
629 myeloid leukemia 9.8
630 rosacea 9.8
631 mitochondrial encephalomyopathy 9.8
632 dermatophytosis 9.8
633 cowpox 9.8
634 granuloma inguinale 9.8
635 hard palate cancer 9.8
636 achalasia 9.8
637 fuchs' heterochromic uveitis 9.8
638 epiglottitis 9.8
639 fatty liver disease 9.8
640 dacryoadenitis 9.8
641 venezuelan equine encephalitis 9.8
642 fasciitis 9.8
643 necrotizing fasciitis 9.8
644 neurofibroma 9.8
645 ulcerative stomatitis 9.8
646 trichinosis 9.8
647 hemophilia 9.8
648 actinic cheilitis 9.8
649 amniotic band syndrome 9.8
650 catastrophic antiphospholipid syndrome 9.8
651 charles bonnet syndrome 9.8
652 chronic graft versus host disease 9.8
653 desmoplastic infantile ganglioglioma 9.8
654 drug reaction with eosinophilia and systemic symptoms 9.8
655 febrile ulceronecrotic mucha-habermann disease 9.8
656 fibromatosis 9.8
657 foix chavany marie syndrome 9.8
658 gianotti crosti syndrome 9.8
659 giant cell myocarditis 9.8
660 granulocytopenia 9.8
661 granulomatous rosacea 9.8
662 grover's disease 9.8
663 herpes zoster ophthalmicus 9.8
664 homologous wasting disease 9.8
665 human t-cell leukemia virus type 1 9.8
666 idiopathic achalasia 9.8
667 infantile digital fibromatosis 9.8
668 leukoplakia 9.8
669 malakoplakia 9.8
670 med23 9.8
671 mycobacterium chelonae 9.8
672 neuromyelitis optica spectrum disorder 9.8
673 new-onset refractory status epilepticus 9.8
674 oral lichen planus 9.8
675 parainfluenza virus type 3 9.8
676 pityriasis lichenoides 9.8
677 pityriasis lichenoides chronica 9.8
678 pityriasis lichenoides et varioliformis acuta 9.8
679 primary biliary cholangitis 9.8
680 pyogenic granuloma 9.8
681 recurrent respiratory papillomatosis 9.8
682 spondyloenchondrodysplasia 9.8
683 weber syndrome 9.8
684 wells syndrome 9.8
685 meningitis and encephalitis 9.8
686 myoclonus 9.8
687 postherpetic neuralgia 9.8
688 postinfectious encephalomyelitis 9.8
689 seizure disorder 9.8
690 tremor 9.8
691 cerebral atrophy 9.8
692 dysautonomia 9.8
693 febrile seizures 9.8
694 hypersomnia 9.8
695 atopic keratoconjunctivitis 9.8
696 non-herpetic acute limbic encephalitis 9.8
697 acute transverse myelitis 9.8
698 vulvar intraepithelial neoplasia 9.8
699 infectious epithelial keratitis 9.8
700 rapidly involuting congenital hemangioma 9.8
701 immune hydrops fetalis 9.8
702 igg4-related ophthalmic disease 9.8
703 erythema multiforme major 9.8
704 paraneoplastic pemphigus 9.8
705 pneumococcal meningitis 9.8
706 bickerstaff brainstem encephalitis 9.8
707 pemphigus vegetans 9.8

Graphical network of the top 20 diseases related to Herpes Simplex:



Diseases related to Herpes Simplex

Symptoms & Phenotypes for Herpes Simplex

UMLS symptoms related to Herpes Simplex:


fever, pruritus, snoring, halitosis, pelvic pain

GenomeRNAi Phenotypes related to Herpes Simplex according to GeneCards Suite gene sharing:

27 (showing 9, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 CGAS CREB3 DDX58 EIF2AK2 HCFC1 IFI16
2 Decreased viability GR00221-A-1 9.89 EIF2AK2 TBK1
3 Decreased viability GR00221-A-2 9.89 EIF2AK2 TBK1
4 Decreased viability GR00221-A-3 9.89 EIF2AK2
5 Decreased viability GR00221-A-4 9.89 EIF2AK2
6 Decreased viability GR00301-A 9.89 EIF2AK2 TBK1
7 Decreased viability GR00342-S-1 9.89 EIF2AK2 TBK1 TLR3
8 Decreased viability GR00342-S-2 9.89 EIF2AK2 TBK1 TLR3
9 Decreased viability GR00402-S-2 9.89 EIF2AK2 TBK1 TLR3

MGI Mouse Phenotypes related to Herpes Simplex:

47 (showing 6, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 CGAS DDX58 EIF2AK2 PILRA PML POU2F1
2 homeostasis/metabolism MP:0005376 10.1 CGAS DDX58 IRF3 NECTIN1 PILRA PML
3 immune system MP:0005387 10.1 CGAS DDX58 EIF2AK2 IRF3 PILRA PML
4 mortality/aging MP:0010768 9.83 CGAS DDX58 EIF2AK2 HCFC1 NECTIN1 PILRA
5 liver/biliary system MP:0005370 9.76 DDX58 HCFC1 PILRA POU2F1 TBK1 TICAM1
6 neoplasm MP:0002006 9.1 DDX58 EIF2AK2 PML TAP1 TICAM1 TLR3

Drugs & Therapeutics for Herpes Simplex

Drugs for Herpes Simplex (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 310, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Docosanol Approved, Investigational Phase 4 661-19-8, 30303-65-2 12620
2
Acyclovir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59277-89-3 2022
3
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 82410-32-0 3454
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
6
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
8
Tenofovir Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147127-20-6 464205
9
Metronidazole Approved Phase 4 443-48-1 4173
10
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
11
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
12
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
13
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
14
Miconazole Approved, Investigational, Vet_approved Phase 4,Early Phase 1 22916-47-8 4189
15
Nevirapine Approved Phase 4 129618-40-2 4463
16
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
17
Emtricitabine Approved, Investigational Phase 4,Not Applicable 143491-57-0 60877
18
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 5284616 6436030
19
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
20
Penciclovir Approved Phase 4,Phase 3 39809-25-1 4725
21
Famciclovir Approved, Investigational Phase 4,Phase 3,Phase 2 104227-87-4 3324
22
Difluprednate Approved Phase 4 23674-86-4 443936
23
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
24
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
25 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Ganciclovir triphosphate Phase 4,Phase 2,Phase 1,Not Applicable
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Antiparasitic Agents Phase 4,Phase 2
31 Antiprotozoal Agents Phase 4,Phase 2
32 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Ophthalmic Solutions Phase 4
34 Prednisolone acetate Phase 4,Phase 3
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Not Applicable
37 Autonomic Agents Phase 4,Phase 3,Phase 1
38 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Methylprednisolone Acetate Phase 4,Phase 3
40 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Neuroprotective Agents Phase 4,Phase 3
44 Dermatologic Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
45 Protective Agents Phase 4,Phase 3,Phase 2
46 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Antirheumatic Agents Phase 4,Phase 1
49 Gastrointestinal Agents Phase 4,Phase 3,Phase 1
50 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
51 Anti-HIV Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
52 Denatonium Phase 4
53 Anti-Retroviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
54 Reverse Transcriptase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
55 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
56 Antihypertensive Agents Phase 4
57 Oxytocics Phase 4
58 Lubricant Eye Drops Phase 4
59 Benzalkonium Compounds Phase 4
60 Anti-Infective Agents, Local Phase 4,Phase 2,Not Applicable,Early Phase 1
61 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Not Applicable
62 Antitubercular Agents Phase 4,Phase 3
63 Antiemetics Phase 4,Phase 3,Phase 1
64 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
65 Cyclosporins Phase 4
66 Antifungal Agents Phase 4,Early Phase 1
67 Calcineurin Inhibitors Phase 4
68 Atazanavir Sulfate Phase 4,Phase 3
69 Cytochrome P-450 CYP3A Inducers Phase 4
70
protease inhibitors Phase 4,Phase 3,Phase 1
71 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Not Applicable
72 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3
73 HIV Protease Inhibitors Phase 4,Phase 3,Phase 1
74 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
75 Antioxidants Phase 4
76
Edetic Acid Approved, Vet_approved Phase 3,Phase 1 60-00-4, 62-33-9 6049
77
Ethanol Approved Phase 3,Phase 2,Early Phase 1 64-17-5 702
78
Cetylpyridinium Approved Phase 3 7773-52-6
79
Pentetic acid Approved Phase 3,Phase 1 67-43-6
80
Halofantrine Approved Phase 3 69756-53-2 37393
81
Zinc Approved, Investigational Phase 3,Not Applicable 7440-66-6 32051
82
Aluminum sulfate Approved Phase 3,Phase 1,Phase 2 10043-01-3
83
Sodium Citrate Approved, Investigational Phase 3,Phase 1 68-04-2
84
Foscarnet Approved Phase 3,Phase 2,Phase 1,Not Applicable 4428-95-9, 63585-09-1 3415
85
Vidarabine Approved, Investigational Phase 3 24356-66-9 21704 32326
86
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
87
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
88
Melphalan Approved Phase 3 148-82-3 460612 4053
89
Valganciclovir Approved, Investigational Phase 2, Phase 3 175865-60-8 64147
90
Methylene blue Approved, Investigational Phase 3 61-73-4
91
Simvastatin Approved Phase 3 79902-63-9 54454
92
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
93
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1 1177-87-3
94
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1 77-92-9 311
95
Phosphonoacetic Acid Experimental Phase 3,Phase 2,Phase 1,Not Applicable 4408-78-0 546
96 Pulmonary Surfactants Phase 3
97 Soy Bean Phase 3
98 5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol Phase 3,Phase 2
99 Vaccines Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
100 Micronutrients Phase 3,Early Phase 1
101 Nutrients Phase 3,Early Phase 1
102 Trace Elements Phase 3,Early Phase 1
103 Monophosphoryl lipid A Phase 3,Phase 1
104 Radiation-Protective Agents Phase 3
105 interferons Phase 3
106 polysaccharide-K Phase 3,Phase 2
107 Interferon Inducers Phase 3
108 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1,Not Applicable
109 Citrate Phase 3,Phase 1
110 Antimetabolites Phase 3,Phase 1,Not Applicable
111 Hydrocortisone 17-butyrate 21-propionate Phase 3
112 Hydrocortisone hemisuccinate Phase 3
113 Alkylating Agents Phase 3
114 Antineoplastic Agents, Alkylating Phase 3
115 Hydrocortisone-17-butyrate Phase 3
116 Antipsychotic Agents Phase 3,Phase 2
117 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
118 Psychotropic Drugs Phase 3
119 Hypolipidemic Agents Phase 3
120 Tranquilizing Agents Phase 3
121 Anticholesteremic Agents Phase 3
122 Lipid Regulating Agents Phase 3
123 BB 1101 Phase 3,Phase 1
124
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
125
Clobetasol Approved, Experimental, Investigational Phase 2,Not Applicable 25122-46-7, 25122-41-2 5311051 32798
126 Fialuridine Approved, Investigational Phase 2 69123-98-4
127
Glycolic acid Approved, Investigational Phase 2 79-14-1 757
128
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2,Phase 1 1187560-31-1
129
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
130
Progesterone Approved, Vet_approved Phase 1, Phase 2 57-83-0 5994
131
nivolumab Approved Phase 2,Phase 1 946414-94-4
132
Pembrolizumab Approved Phase 2 1374853-91-4
133
Digoxin Approved Phase 2 20830-75-5 2724385 30322
134
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700