MCID: HRP025
MIFTS: 39

Herpes Simplex Virus Keratitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Herpes Simplex Virus Keratitis

MalaCards integrated aliases for Herpes Simplex Virus Keratitis:

Name: Herpes Simplex Virus Keratitis 12 58 15 17
Keratitis, Dendritic 43 71
Dendritic Keratitis 12 17
Keratitis, Herpetic 43 71
Herpetic Keratitis 58
Keratitis Herpetic 54
Hsv Keratitis 58

Characteristics:

Orphanet epidemiological data:

58
herpes simplex virus keratitis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:0080158
ICD10 via Orphanet 33 B00.5+ H19.1*
UMLS via Orphanet 72 C0019357
Orphanet 58 ORPHA137586
UMLS 71 C0019357 C0022570

Summaries for Herpes Simplex Virus Keratitis

Disease Ontology : 12 A keratitis that has material basis in herpes simplex type infection.

MalaCards based summary : Herpes Simplex Virus Keratitis, also known as keratitis, dendritic, is related to keratitis, hereditary and uveitis. An important gene associated with Herpes Simplex Virus Keratitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Measles. The drugs Acyclovir and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone.

Related Diseases for Herpes Simplex Virus Keratitis

Diseases related to Herpes Simplex Virus Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 31.1 TAT CXCL8 CD4
2 uveitis 30.8 ICAM1 CXCL8 CCL2
3 conjunctivitis 30.7 ICAM1 CXCL8 CCL2
4 keratoconjunctivitis 30.6 ICAM1 CXCL8 CCL2
5 papillary conjunctivitis 30.5 CXCL8 CCL2
6 severe nonproliferative diabetic retinopathy 30.5 ICAM1 CCL2
7 meningitis 30.1 ICAM1 CXCL8 CCL2
8 chronic conjunctivitis 30.1 CXCL8 CD4
9 blepharoconjunctivitis 29.9 CXCL8 CD4
10 iritis 29.6 CD4 C21orf91
11 eye disease 29.6 TKT ICAM1 CXCL8 CD4 CCL2
12 macular retinal edema 29.6 IFNB1 ICAM1 CXCL8 CCL2
13 dermatitis, atopic 29.4 ICAM1 CXCL8 CD4 CCL2
14 contact dermatitis 29.2 ICAM1 CXCL8 CD4 CCL2
15 malaria 28.4 IFNB1 ICAM1 CXCL8 CD4 CCL2
16 herpes simplex 11.0
17 yemenite deaf-blind hypopigmentation syndrome 10.4
18 fuchs' heterochromic uveitis 10.4 CXCL8 CCL2
19 suppression amblyopia 10.4
20 amblyopia 10.4
21 endotheliitis 10.4
22 denture stomatitis 10.4 CXCL8 CCL2
23 toxicodendron dermatitis 10.4 ICAM1 CXCL8
24 tuberculous meningitis 10.4 CXCL8 CCL2
25 background diabetic retinopathy 10.3 ICAM1 CCL2
26 vitreous disease 10.3 CXCL8 CCL2
27 relapsing polychondritis 10.3 CXCL8 CCL2
28 post-thrombotic syndrome 10.3 ICAM1 CCL2
29 keratoconus 10.3
30 drug-induced lupus erythematosus 10.3 CXCL8 CCL2
31 macular holes 10.3 CXCL8 CCL2
32 chronic eosinophilic pneumonia 10.3 ICAM1 CCL2
33 periapical granuloma 10.3 CXCL8 CCL2
34 corneal edema 10.3
35 superficial keratitis 10.3
36 punctate epithelial keratoconjunctivitis 10.3
37 retinal vascular occlusion 10.3 ICAM1 CCL2
38 neutrophil migration 10.2 ICAM1 CXCL8
39 acanthamoeba keratitis 10.2
40 infectious epithelial keratitis 10.2
41 radiculopathy 10.2 CXCL8 CCL2
42 herpes zoster 10.2
43 erythema multiforme 10.2 ICAM1 CXCL8
44 neuroretinitis 10.2
45 retinitis 10.2
46 ocular hypertension 10.2
47 bacteriuria 10.2 CXCL8 CCL2
48 leukostasis 10.2 ICAM1 CCL2
49 pleurisy 10.2 ICAM1 CXCL8 CCL2
50 retinal vasculitis 10.2 IFNB1 CCL2

Graphical network of the top 20 diseases related to Herpes Simplex Virus Keratitis:



Diseases related to Herpes Simplex Virus Keratitis

Symptoms & Phenotypes for Herpes Simplex Virus Keratitis

Drugs & Therapeutics for Herpes Simplex Virus Keratitis

Drugs for Herpes Simplex Virus Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 4 59277-89-3 2022
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Difluprednate Approved Phase 4 23674-86-4 443936
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Ophthalmic Solutions Phase 4
10 Antiviral Agents Phase 4
11 Anti-Infective Agents Phase 4
12 Methylprednisolone Acetate Phase 4
13 valacyclovir Phase 4
14 Anti-Inflammatory Agents Phase 3
15 Antiemetics Phase 3
16 Neuroprotective Agents Phase 3
17 Gastrointestinal Agents Phase 3
18 Hormone Antagonists Phase 3
19 Autonomic Agents Phase 3
20 Antineoplastic Agents, Hormonal Phase 3
21 Protective Agents Phase 3
22 glucocorticoids Phase 3
23 Hormones Phase 3
24
Salicylic acid Approved, Investigational, Vet_approved Phase 1 69-72-7 338
25
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
26 Anti-Inflammatory Agents, Non-Steroidal Phase 1
27 Analgesics, Non-Narcotic Phase 1
28 Antirheumatic Agents Phase 1
29 Analgesics Phase 1
30 Fibrinolytic Agents Phase 1
31 Platelet Aggregation Inhibitors Phase 1
32 Antipyretics Phase 1
33 Cyclooxygenase Inhibitors Phase 1
34
Ethanol Approved 64-17-5 702
35
Ganciclovir Approved, Investigational 82410-32-0 3454
36
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved 83-88-5 493570
37 Pyranoprofen
38 Central Nervous System Depressants
39 Anesthetics
40 Antibodies, Monoclonal
41 Antibodies
42 Immunoglobulins
43 Immunologic Factors
44 polysaccharide-K
45 Lubricant Eye Drops
46 Pharmaceutical Solutions
47 Vitamin B2
48 Dextrans
49 Proxymetacaine
50 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
2 Comparison Between the Sensibility of the Flocked Swab and the Traditional Fiber Swab for the Diagnosis of the Herpes Simplex Epithelial Keratitis Terminated NCT02045082 Phase 4
3 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
4 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3 Acyclovir
5 Phase 2, Randomized, Double-masked, Vehicle-controlled, Dose-escalation Study Evaluating Efficacy/Safety of Nexagon in Subjects With Persistent Corneal Epithelial Defects (PED) Resulting From Corneal Epithelial Debridement During Diabetic Vitrectomy Surgery, Herpes Simples Virus (HSV) Keratitis, Herpes Zoster Virus (HZV) Keratitis, Corneal Burns, Post-photorefractive Keratectomy (Post-PRK), or Post-corneal Transplant Surgery. Terminated NCT01165450 Phase 2 Nexagon;Vehicle only
6 A 30-Day Double-Masked Study to Determine the Effect of Oral Valacyclovir or Oral Valacyclovir Plus Aspirin on the Shedding of Herpes Simplex Virus DNA in the Tears and Saliva of Volunteers Without Clinical Signs of Ocular Herpetic Disease Unknown status NCT00587496 Phase 1 valacyclovir hydrochloride;placebo;valacyclovir plus aspirin
7 Observation on Effect of Anti--inflammatory and Inhibition of Recurrence on the Herpes Simplex Keratitis After Topical NSAIDs Administration Unknown status NCT03013959 Pranoprofen
8 Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP Unknown status NCT02826174 Anti-Rejection Agents;Anti-Inflammatory Agents
9 A Study to Compare the Efficacy of Two Potential Diagnostic Assays: a Fluorescein Conjugated Monoclonal Antibody in Vivo Assay and Nested Real Time PCR Assay to Rapidly and Accurately Diagnose Herpes Simplex Keratitis. Completed NCT00357812
10 Ganciclovir 0,15% Ophthalmic Gel in the Treatment of Adenovirus Keratoconjuntivitis Completed NCT01349452 Ganciclovir;Artificial tear
11 Evaluation of Corneal Hysteresis and Corneal Resistance Factor After Corneal Cross-linking for Keratoconus Completed NCT01411384
12 A Randomized Controlled Clinical Trial of Corneal Debridement for the Treatment of Herpes Simplex Epithelial Keratitis Recruiting NCT03217474 Ganciclovir (GCV)
13 Intraocular Pressure Monitoring With Implantable Intraocular Pressure Sensor for Improved Glaucoma Monitoring in Patients With Boston Keratoprosthesis Type 1 Withdrawn NCT03421548

Search NIH Clinical Center for Herpes Simplex Virus Keratitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Idoxuridine
Trifluridine
Vidarabine

Cochrane evidence based reviews: keratitis, dendritic

Genetic Tests for Herpes Simplex Virus Keratitis

Anatomical Context for Herpes Simplex Virus Keratitis

MalaCards organs/tissues related to Herpes Simplex Virus Keratitis:

40
Eye, Endothelial, Bone, T Cells, Liver, Salivary Gland, Testes

Publications for Herpes Simplex Virus Keratitis

Articles related to Herpes Simplex Virus Keratitis:

(show top 50) (show all 137)
# Title Authors PMID Year
1
The Role of C21orf91 in Herpes Simplex Virus Keratitis. 61
31757016 2019
2
Herpes Simplex Virus Keratitis. 61
31483360 2019
3
Management of Herpes Simplex Virus Keratitis in the Pediatric Population. 61
31192983 2019
4
Macrodendrite in a Patient With Herpes Simplex Virus Keratitis. 61
30763420 2019
5
Corneal esthesiometry and sub-basal nerves morphological changes in herpes simplex virus keratitis/uveitis patients. 61
30918808 2019
6
Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis. 61
29749113 2018
7
Transcriptional Profile and Integrative Analyses of Long Noncoding RNAs in Primary Human Corneal Epithelial Cells in Response to HSV-1 Infection. 61
30032655 2018
8
Management of Herpes Simplex Virus Keratitis in the Pediatric Population. 61
29794647 2018
9
Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation. 61
30232207 2018
10
Rituximab and bilateral HSV epithelial keratitis in a patient with mucous membrane pemphigoid. 61
30141181 2018
11
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease. 61
29256984 2018
12
Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. 61
29370719 2018
13
Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. 61
28495905 2018
14
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - comment. 61
28544103 2017
15
Update on the Management of Infectious Keratitis. 61
28942073 2017
16
QUIESCENT HERPES SIMPLEX KERATITIS REACTIVATION AFTER INTRAVITREAL INJECTION OF DEXAMETHASONE IMPLANT. 61
27508424 2017
17
Corneal Pseudodendritic Lesions Masquerading as Herpetic Keratitis in a Patient With Tyrosinemia Type I. 61
26322918 2017
18
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - comment. 61
27620850 2017
19
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - response. 61
27635860 2017
20
Herpes Simplex Virus Keratitis and Resistance to Acyclovir. 61
28060081 2017
21
Long-term Outcomes of Pediatric Penetrating Keratoplasty for Herpes Simplex Virus Keratitis. 61
27746299 2017
22
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents. 61
27273328 2016
23
Microsporidial Stromal Keratitis: Clinical Features, Unique Diagnostic Criteria, and Treatment Outcomes in a Large Case Series. 61
27467044 2016
24
Both CD8+ and CD4+ T Cells Contribute to Corneal Clouding and Viral Clearance following Vaccinia Virus Infection in C57BL/6 Mice. 61
27170749 2016
25
[Keratitis - Infectious or Autoimmune?]. 61
27468096 2016
26
Herpes Simplex Keratitis in Rheumatoid Arthritis Patients. 61
25140583 2016
27
Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. 61
27066737 2016
28
Dendritiform Keratopathy Associated with Exposure to Polyquarternium-1, a Common Ophthalmic Preservative. 61
26686962 2016
29
Lychee flower extract inhibits proliferation and viral replication of HSV-1-infected corneal epithelial cells. 61
26937165 2016
30
[The German Acanthamoeba keratitis register: Initial results of a multicenter study]. 61
25833754 2015
31
A systematic review and meta-analysis to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpetic keratitis by Day 7 of treatment. 61
25928630 2015
32
Deep anterior lamellar keratoplasty using irradiated acellular cornea with amniotic membrane transplantation for intractable ocular surface diseases. 61
25829823 2015
33
Incidence of Herpes Simplex Virus Keratitis in HIV/AIDS patients compared with the general population. 61
25914741 2015
34
Clinical Correlation between Placido, Scheimpflug and LED Color Reflection Topographies in Imaging of a Scarred Cornea. 61
25408671 2014
35
Metaherpetic corneal disease in a dog associated with partial limbal stem cell deficiency and neurotrophic keratitis. 61
22958361 2013
36
Herpes simplex virus keratitis: epidemiological observations. 61
23597662 2013
37
Misdiagnosis of orthokeratology-related Acanthamoeba keratitis as herpes simplex virus keratitis. 61
23231627 2013
38
[Epithelial herpes simplex virus keratitis]. 61
23480891 2013
39
Corneal changes in ectrodactyly-ectodermal dysplasia-cleft lip and palate syndrome: case series and literature review. 61
22618129 2012
40
Translationally controlled tumour protein (TCTP) is present in human cornea and increases in herpetic keratitis. 61
22853445 2012
41
Deep anterior lamellar keratoplasty using acellular corneal tissue for prevention of allograft rejection in high-risk corneas. 61
21803324 2011
42
Isolation of Kingella denitrificans from a corneal ulcer. 61
21099406 2011
43
["Herpetic keratitis". Various expressions require different therapeutic approaches]. 61
21448683 2011
44
Photographic monitoring of herpes simplex virus keratitis during anti-inflammatory treatment. 61
21320979 2011
45
Dissemination of knowledge from randomized clinical trials for herpes simplex virus keratitis. 61
21149792 2010
46
Nongenital herpes simplex virus. 61
21121552 2010
47
Selective changes in human corneal sensation associated with herpes simplex virus keratitis. 61
20375335 2010
48
Kinetics of immune cell infiltration in vaccinia virus keratitis. 61
20375330 2010
49
Herpes simplex virus keratitis: histopathology and corneal allograft outcomes. 61
20543901 2010
50
Aciclovir-resistant herpes keratitis. 61
20447128 2010

Variations for Herpes Simplex Virus Keratitis

Expression for Herpes Simplex Virus Keratitis

Search GEO for disease gene expression data for Herpes Simplex Virus Keratitis.

Pathways for Herpes Simplex Virus Keratitis

GO Terms for Herpes Simplex Virus Keratitis

Biological processes related to Herpes Simplex Virus Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.63 IFNB1 CD4 CCL2
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.61 ICAM1 CD4 CCL2
3 cellular response to lipopolysaccharide GO:0071222 9.54 ICAM1 CXCL8 CCL2
4 cellular response to tumor necrosis factor GO:0071356 9.43 ICAM1 CXCL8 CCL2
5 cellular response to fibroblast growth factor stimulus GO:0044344 9.4 CXCL8 CCL2
6 positive regulation of T cell activation GO:0050870 9.32 CD4 CCL2
7 PERK-mediated unfolded protein response GO:0036499 9.16 CXCL8 CCL2
8 cellular response to interleukin-1 GO:0071347 9.13 ICAM1 CXCL8 CCL2
9 cytokine-mediated signaling pathway GO:0019221 9.02 IFNB1 ICAM1 CXCL8 CD4 CCL2

Molecular functions related to Herpes Simplex Virus Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IFNB1 CXCL8 CCL2

Sources for Herpes Simplex Virus Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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