MCID: HRP025
MIFTS: 38

Herpes Simplex Virus Keratitis

Categories: Eye diseases

Aliases & Classifications for Herpes Simplex Virus Keratitis

MalaCards integrated aliases for Herpes Simplex Virus Keratitis:

Name: Herpes Simplex Virus Keratitis 12 15 17
Keratitis, Dendritic 45 74
Dendritic Keratitis 12 17
Keratitis, Herpetic 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0080158

Summaries for Herpes Simplex Virus Keratitis

Disease Ontology : 12 A keratitis that has material basis in herpes simplex type infection.

MalaCards based summary : Herpes Simplex Virus Keratitis, also known as keratitis, dendritic, is related to uveitis and keratoconjunctivitis. An important gene associated with Herpes Simplex Virus Keratitis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Human cytomegalovirus infection and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Difluprednate and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes.

Related Diseases for Herpes Simplex Virus Keratitis

Diseases related to Herpes Simplex Virus Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.4 CCL2 ICAM1
2 keratoconjunctivitis 29.8 CXCL8 ICAM1
3 herpes simplex 11.0
4 keratitis, hereditary 10.8
5 stromal keratitis 10.3
6 acanthamoeba keratitis 10.2
7 pneumonia 10.2 CCL2 CXCL8
8 israeli tick typhus 10.2 CCL2 CXCL8
9 denture stomatitis 10.2 CCL2 CXCL8
10 viral meningitis 10.2 CCL2 CXCL8
11 meningitis 10.2 CCL2 CXCL8
12 bacteriuria 10.2 CCL2 CXCL8
13 pleural tuberculosis 10.2 CCL2 CXCL8
14 macular holes 10.2 CCL2 CXCL8
15 tuberculous meningitis 10.2 CCL2 CXCL8
16 acute cystitis 10.2 CCL2 CXCL8
17 cystitis 10.2 CCL2 CXCL8
18 viral encephalitis 10.1 CCL2 CXCL8
19 pyelonephritis 10.1 CCL2 CXCL8
20 leptospirosis 10.1 CCL2 CXCL8
21 severe acute respiratory syndrome 10.1 CCL2 CXCL8
22 silicosis 10.1 CCL2 CXCL8
23 extrinsic allergic alveolitis 10.1 CCL2 CXCL8
24 pneumoconiosis 10.1 CCL2 CXCL8
25 chorioamnionitis 10.1 CCL2 CXCL8
26 acute proliferative glomerulonephritis 10.1 CCL2 ICAM1
27 glomerulonephritis 10.1 CCL2 ICAM1
28 macular retinal edema 10.1 CCL2 ICAM1
29 post-thrombotic syndrome 10.1 CCL2 ICAM1
30 bone inflammation disease 10.1 CCL2 CXCL8
31 diabetic macular edema 10.1 CCL2 ICAM1
32 crescentic glomerulonephritis 10.1 CCL2 ICAM1
33 cytomegalovirus infection 10.1 CCL2 CXCL8
34 extrinsic cardiomyopathy 10.1 CCL2 ICAM1
35 autoimmune uveitis 10.1 CCL2 ICAM1
36 chagas disease 10.1 CCL2 CXCL8
37 toxicodendron dermatitis 10.1 CXCL8 ICAM1
38 pemphigus vulgaris, familial 10.1
39 wiskott-aldrich syndrome 10.1
40 alport syndrome 10.1
41 cataract 10.1
42 pemphigus vulgaris 10.1
43 pemphigus 10.1
44 lichen planus 10.1
45 anterior uveitis 10.1
46 retinal vascular disease 10.1 CCL2 ICAM1
47 periodontitis 10.1 CCL2 CXCL8
48 endometrial stromal sarcoma 10.1 CCL2 CXCL8
49 pulmonary sarcoidosis 10.1 CCL2 ICAM1
50 autoimmune disease of central nervous system 10.1 CCL2 ICAM1

Graphical network of the top 20 diseases related to Herpes Simplex Virus Keratitis:



Diseases related to Herpes Simplex Virus Keratitis

Symptoms & Phenotypes for Herpes Simplex Virus Keratitis

Drugs & Therapeutics for Herpes Simplex Virus Keratitis

Drugs for Herpes Simplex Virus Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Difluprednate Approved Phase 4 23674-86-4 443936
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Acyclovir Approved Phase 4 59277-89-3 2022
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Ophthalmic Solutions Phase 4
9 Methylprednisolone Acetate Phase 4
10 Anti-Infective Agents Phase 4
11 Antiviral Agents Phase 4
12 valacyclovir Phase 4
13 Prednisolone acetate Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops

Search NIH Clinical Center for Herpes Simplex Virus Keratitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: keratitis, dendritic

Genetic Tests for Herpes Simplex Virus Keratitis

Anatomical Context for Herpes Simplex Virus Keratitis

MalaCards organs/tissues related to Herpes Simplex Virus Keratitis:

42
Eye, T Cells, Testes, Endothelial, B Cells, Lung, Bone

Publications for Herpes Simplex Virus Keratitis

Articles related to Herpes Simplex Virus Keratitis:

(show top 50) (show all 66)
# Title Authors Year
1
Corneal esthesiometry and sub-basal nerves morphological changes in herpes simplex virus keratitis/uveitis patients. ( 30918808 )
2019
2
Macrodendrite in a Patient With Herpes Simplex Virus Keratitis. ( 30763420 )
2019
3
Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation. ( 30232207 )
2018
4
Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis. ( 29749113 )
2018
5
Management of Herpes Simplex Virus Keratitis in the Pediatric Population. ( 29794647 )
2018
6
Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. ( 29370719 )
2018
7
Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. ( 28495905 )
2018
8
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - comment. ( 28544103 )
2017
9
Herpes Simplex Virus Keratitis and Resistance to Acyclovir. ( 28060081 )
2017
10
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - comment. ( 27620850 )
2017
11
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - response. ( 27635860 )
2017
12
Long-term Outcomes of Pediatric Penetrating Keratoplasty for Herpes Simplex Virus Keratitis. ( 27746299 )
2017
13
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents. ( 27273328 )
2016
14
Incidence of Herpes Simplex Virus Keratitis in HIV/AIDS patients compared with the general population. ( 25914741 )
2015
15
Misdiagnosis of orthokeratology-related Acanthamoeba keratitis as herpes simplex virus keratitis. ( 23231627 )
2013
16
Herpes simplex virus keratitis: epidemiological observations. ( 23597662 )
2013
17
Photographic monitoring of herpes simplex virus keratitis during anti-inflammatory treatment. ( 21320979 )
2011
18
Selective changes in human corneal sensation associated with herpes simplex virus keratitis. ( 20375335 )
2010
19
Herpes simplex virus keratitis: histopathology and corneal allograft outcomes. ( 20543901 )
2010
20
Dissemination of knowledge from randomized clinical trials for herpes simplex virus keratitis. ( 21149792 )
2010
21
New-onset herpes simplex virus keratitis after cataract surgery. ( 19092420 )
2009
22
Pediatric herpes simplex virus keratitis. ( 19387223 )
2009
23
Recurrence rates of herpes simplex virus keratitis in contact lens and non-contact lens wearers. ( 19502988 )
2009
24
Herpes simplex virus keratitis: histopathologic inflammation and corneal allograft rejection. ( 19576497 )
2009
25
Conjunctival lichen planus in a patient with herpes simplex virus keratitis. ( 19654517 )
2009
26
Herpes simplex virus keratitis: histopathologic neovascularization and corneal allograft failure. ( 19724220 )
2009
27
Endothelial involvement in herpes simplex virus keratitis: an in vivo confocal microscopy study. ( 19744733 )
2009
28
Is herpes simplex virus keratitis a different disease in children? ( 18045258 )
2008
29
Alport syndrome with recurrent herpes simplex virus keratitis. ( 18043194 )
2007
30
Evidence-based treatment of herpes simplex virus keratitis: a systematic review. ( 17660897 )
2007
31
Recurrence of bilateral herpes simplex virus keratitis following bimatoprost use. ( 16531673 )
2006
32
Successful treatment of Paecilomyces lilacinus keratitis in a patient with a history of herpes simplex virus keratitis. ( 17172908 )
2006
33
Incidence of herpes simplex virus keratitis in France. ( 15878072 )
2005
34
Herpes simplex virus keratitis after laser in situ keratomileusis. ( 16128340 )
2005
35
Herpes simplex virus keratitis in children. ( 15364233 )
2004
36
Human herpes simplex virus keratitis: the pathogenesis revisited. ( 15621867 )
2004
37
Pathogenesis and management of herpes simplex virus keratitis. ( 14631397 )
2003
38
Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma. ( 11860979 )
2002
39
Mapping of genes involved in murine herpes simplex virus keratitis: identification of genes and their modifiers. ( 11884574 )
2002
40
Predictors of recurrent herpes simplex virus keratitis. Herpetic Eye Disease Study Group. ( 11248812 )
2001
41
Oral acyclovir for the management of herpes simplex virus keratitis in children. ( 10690825 )
2000
42
Epithelial changes in early primary herpes simplex virus keratitis. Photomicrographic observations in a case of human infection. ( 11167239 )
2000
43
Classification of herpes simplex virus keratitis and anterior uveitis. ( 10090358 )
1999
44
Classification of herpes simplex virus keratitis. ( 10090359 )
1999
45
Early epithelial changes in recurrent herpes simplex virus keratitis: a non-contact photomicrographic study in vivo in the human cornea. ( 9686852 )
1998
46
Foscarnet eyedrops in recurrence prophylaxis of herpes simplex virus keratitis. ( 9881570 )
1998
47
Herpes simplex virus keratitis among patients who are positive or negative for human immunodeficiency virus: an epidemiologic study. ( 9022115 )
1997
48
Genomic polymorphism in herpes simplex virus keratitis. ( 9106185 )
1997
49
Newly acquired herpes simplex virus keratitis after penetrating keratoplasty. ( 9111258 )
1997
50
Analysis of T cell receptor V beta gene expression in B cell deficient mice after experimental herpes simplex virus keratitis. ( 9385402 )
1997

Variations for Herpes Simplex Virus Keratitis

Expression for Herpes Simplex Virus Keratitis

Search GEO for disease gene expression data for Herpes Simplex Virus Keratitis.

Pathways for Herpes Simplex Virus Keratitis

Pathways related to Herpes Simplex Virus Keratitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.57 CCL2 CXCL8 ICAM1
2
Show member pathways
11.84 CCL2 CXCL8 ICAM1
3
Show member pathways
11.67 CCL2 CXCL8 ICAM1
4
Show member pathways
11.66 CCL2 CXCL8
5 11.63 CCL2 ICAM1
6 11.62 CCL2 CXCL8 ICAM1
7 11.58 CXCL8 ICAM1
8 11.55 CCL2 CXCL8 ICAM1
9
Show member pathways
11.54 CXCL8 ICAM1
10 11.46 CXCL8 ICAM1
11 11.43 CCL2 CXCL8 ICAM1
12 11.34 CCL2 CXCL8
13
Show member pathways
11.32 CXCL8 ICAM1
14 11.29 CCL2 CXCL8 ICAM1
15
Show member pathways
11.27 CCL2 CXCL8
16 11.14 CXCL8 ICAM1
17 10.99 CCL2 CXCL8
18 10.83 CCL2 ICAM1
19 10.82 CCL2 CXCL8 ICAM1
20 10.61 CCL2 ICAM1
21 10.49 CCL2 CXCL8 ICAM1

GO Terms for Herpes Simplex Virus Keratitis

Biological processes related to Herpes Simplex Virus Keratitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.5 CCL2 CXCL8 ICAM1
2 response to organic cyclic compound GO:0014070 9.49 ICAM1 TAT
3 cellular response to interferon-gamma GO:0071346 9.48 CCL2 ICAM1
4 neutrophil chemotaxis GO:0030593 9.46 CCL2 CXCL8
5 chemokine-mediated signaling pathway GO:0070098 9.43 CCL2 CXCL8
6 cellular response to lipopolysaccharide GO:0071222 9.43 CCL2 CXCL8 ICAM1
7 regulation of cell adhesion GO:0030155 9.4 CXCL8 ICAM1
8 cellular response to fibroblast growth factor stimulus GO:0044344 9.37 CCL2 CXCL8
9 PERK-mediated unfolded protein response GO:0036499 9.16 CCL2 CXCL8
10 cellular response to tumor necrosis factor GO:0071356 9.13 CCL2 CXCL8 ICAM1
11 cellular response to interleukin-1 GO:0071347 8.8 CCL2 CXCL8 ICAM1

Molecular functions related to Herpes Simplex Virus Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CCL2 CXCL8

Sources for Herpes Simplex Virus Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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