MCID: HRP025
MIFTS: 38

Herpes Simplex Virus Keratitis

Categories: Eye diseases

Aliases & Classifications for Herpes Simplex Virus Keratitis

MalaCards integrated aliases for Herpes Simplex Virus Keratitis:

Name: Herpes Simplex Virus Keratitis 12 15
Keratitis, Dendritic 44 73
Keratitis, Herpetic 44 73
Dendritic Keratitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080158

Summaries for Herpes Simplex Virus Keratitis

Disease Ontology : 12 A keratitis that has material basis in herpes simplex type infection.

MalaCards based summary : Herpes Simplex Virus Keratitis, also known as keratitis, dendritic, is related to uveitis and keratoconjunctivitis. An important gene associated with Herpes Simplex Virus Keratitis is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Influenza A and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Methylprednisolone hemisuccinate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and testes.

Related Diseases for Herpes Simplex Virus Keratitis

Diseases related to Herpes Simplex Virus Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.3 CCL2 ICAM1
2 keratoconjunctivitis 29.8 CXCL8 ICAM1
3 herpes simplex 11.0
4 acanthamoeba keratitis 10.2
5 acute proliferative glomerulonephritis 10.1 CCL2 ICAM1
6 chronic eosinophilic pneumonia 10.1 CCL2 ICAM1
7 macular retinal edema 10.1 CCL2 ICAM1
8 post-thrombotic syndrome 10.1 CCL2 ICAM1
9 diabetic macular edema 10.1 CCL2 ICAM1
10 crescentic glomerulonephritis 10.1 CCL2 ICAM1
11 extrinsic cardiomyopathy 10.1 CCL2 ICAM1
12 autoimmune uveitis 10.1 CCL2 ICAM1
13 israeli tick typhus 10.1 CCL2 CXCL8
14 denture stomatitis 10.1 CCL2 CXCL8
15 viral meningitis 10.1 CCL2 CXCL8
16 retinal vascular disease 10.1 CCL2 ICAM1
17 meningitis 10.1 CCL2 CXCL8
18 radiculopathy 10.1 CCL2 CXCL8
19 bacteriuria 10.1 CCL2 CXCL8
20 pleural tuberculosis 10.1 CCL2 CXCL8
21 macular holes 10.1 CCL2 CXCL8
22 tuberculous meningitis 10.1 CCL2 CXCL8
23 pulmonary sarcoidosis 10.1 CCL2 ICAM1
24 acute cystitis 10.1 CCL2 CXCL8
25 cystitis 10.1 CCL2 CXCL8
26 autoimmune disease of central nervous system 10.1 CCL2 ICAM1
27 toxicodendron dermatitis 10.1 CXCL8 ICAM1
28 pyelonephritis 10.1 CCL2 CXCL8
29 leptospirosis 10.1 CCL2 CXCL8
30 severe acute respiratory syndrome 10.1 CCL2 CXCL8
31 silicosis 10.1 CCL2 CXCL8
32 extrinsic allergic alveolitis 10.1 CCL2 CXCL8
33 allergic conjunctivitis 10.1 CXCL8 ICAM1
34 conjunctivitis 10.1 CXCL8 ICAM1
35 nose disease 10.1 CXCL8 ICAM1
36 pneumoconiosis 10.1 CCL2 CXCL8
37 arteries, anomalies of 10.1 CCL2 ICAM1
38 neutrophil migration 10.1 CXCL8 ICAM1
39 common cold 10.1 CXCL8 ICAM1
40 chorioamnionitis 10.1 CCL2 CXCL8
41 bone inflammation disease 10.1 CCL2 CXCL8
42 allergic contact dermatitis 10.1 CXCL8 ICAM1
43 contact dermatitis 10.1 CXCL8 ICAM1
44 pulmonary edema 10.1 CXCL8 ICAM1
45 cytomegalovirus infection 10.1 CCL2 CXCL8
46 upper respiratory tract disease 10.1 CXCL8 ICAM1
47 demyelinating disease 10.1 CCL2 ICAM1
48 lymphadenitis 10.1 CXCL8 ICAM1
49 cholesteatoma of middle ear 10.1 ICAM1 LGALS8
50 keratitis, hereditary 10.1

Graphical network of the top 20 diseases related to Herpes Simplex Virus Keratitis:



Diseases related to Herpes Simplex Virus Keratitis

Symptoms & Phenotypes for Herpes Simplex Virus Keratitis

Drugs & Therapeutics for Herpes Simplex Virus Keratitis

Drugs for Herpes Simplex Virus Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Difluprednate Approved Phase 4 23674-86-4 443936
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Acyclovir Approved Phase 4 59277-89-3 2022
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Ophthalmic Solutions Phase 4
9 Prednisolone acetate Phase 4
10 Methylprednisolone acetate Phase 4
11 valacyclovir Phase 4
12 Antiviral Agents Phase 4
13 Anti-Infective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops

Search NIH Clinical Center for Herpes Simplex Virus Keratitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: keratitis, dendritic

Genetic Tests for Herpes Simplex Virus Keratitis

Anatomical Context for Herpes Simplex Virus Keratitis

MalaCards organs/tissues related to Herpes Simplex Virus Keratitis:

41
Eye, T Cells, Testes, B Cells, Lung, Bone, Neutrophil

Publications for Herpes Simplex Virus Keratitis

Articles related to Herpes Simplex Virus Keratitis:

(show top 50) (show all 65)
# Title Authors Year
1
Clinical translation of recommendations from randomized trials for management of herpes simplex virus keratitis. ( 29749113 )
2018
2
Immunization with dendritic cell-based DNA vaccine pRSC-NLDC145.gD-IL21 protects mice against herpes simplex virus keratitis. ( 29370719 )
2018
3
Management of Herpes Simplex Virus Keratitis in the Pediatric Population. ( 29794647 )
2018
4
Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation. ( 30232207 )
2018
5
Long-term Outcomes of Pediatric Penetrating Keratoplasty for Herpes Simplex Virus Keratitis. ( 27746299 )
2017
6
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - comment. ( 28544103 )
2017
7
Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis. ( 28495905 )
2017
8
Herpes Simplex Virus Keratitis and Resistance to Acyclovir. ( 28060081 )
2017
9
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - response. ( 27635860 )
2016
10
Herpes Simplex Virus Keratitis and Resistance to Acyclovir. ( 27941388 )
2016
11
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - comment. ( 27620850 )
2016
12
Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents. ( 27273328 )
2016
13
Incidence of Herpes Simplex Virus Keratitis in HIV/AIDS patients compared with the general population. ( 25914741 )
2015
14
Misdiagnosis of orthokeratology-related Acanthamoeba keratitis as herpes simplex virus keratitis. ( 23231627 )
2013
15
Herpes simplex virus keratitis: epidemiological observations. ( 23597662 )
2013
16
Photographic monitoring of herpes simplex virus keratitis during anti-inflammatory treatment. ( 21320979 )
2011
17
Herpes simplex virus keratitis: histopathology and corneal allograft outcomes. ( 20543901 )
2010
18
Dissemination of knowledge from randomized clinical trials for herpes simplex virus keratitis. ( 21149792 )
2010
19
Selective changes in human corneal sensation associated with herpes simplex virus keratitis. ( 20375335 )
2010
20
Herpes simplex virus keratitis: histopathologic inflammation and corneal allograft rejection. ( 19576497 )
2009
21
Recurrence rates of herpes simplex virus keratitis in contact lens and non-contact lens wearers. ( 19502988 )
2009
22
New-onset herpes simplex virus keratitis after cataract surgery. ( 19092420 )
2009
23
Pediatric herpes simplex virus keratitis. ( 19387223 )
2009
24
Herpes simplex virus keratitis: histopathologic neovascularization and corneal allograft failure. ( 19724220 )
2009
25
Conjunctival lichen planus in a patient with herpes simplex virus keratitis. ( 19654517 )
2009
26
Endothelial involvement in herpes simplex virus keratitis: an in vivo confocal microscopy study. ( 19744733 )
2009
27
Is herpes simplex virus keratitis a different disease in children? ( 18045258 )
2008
28
Evidence-based treatment of herpes simplex virus keratitis: a systematic review. ( 17660897 )
2007
29
Alport syndrome with recurrent herpes simplex virus keratitis. ( 18043194 )
2007
30
Successful treatment of Paecilomyces lilacinus keratitis in a patient with a history of herpes simplex virus keratitis. ( 17172908 )
2006
31
Recurrence of bilateral herpes simplex virus keratitis following bimatoprost use. ( 16531673 )
2006
32
Herpes simplex virus keratitis after laser in situ keratomileusis. ( 16128340 )
2005
33
Incidence of herpes simplex virus keratitis in France. ( 15878072 )
2005
34
Herpes simplex virus keratitis in children. ( 15364233 )
2004
35
Human herpes simplex virus keratitis: the pathogenesis revisited. ( 15621867 )
2004
36
Pathogenesis and management of herpes simplex virus keratitis. ( 14631397 )
2003
37
Mapping of genes involved in murine herpes simplex virus keratitis: identification of genes and their modifiers. ( 11884574 )
2002
38
Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma. ( 11860979 )
2002
39
Predictors of recurrent herpes simplex virus keratitis. Herpetic Eye Disease Study Group. ( 11248812 )
2001
40
Epithelial changes in early primary herpes simplex virus keratitis. Photomicrographic observations in a case of human infection. ( 11167239 )
2000
41
Oral acyclovir for the management of herpes simplex virus keratitis in children. ( 10690825 )
2000
42
Classification of herpes simplex virus keratitis. ( 10090359 )
1999
43
Classification of herpes simplex virus keratitis and anterior uveitis. ( 10090358 )
1999
44
Early epithelial changes in recurrent herpes simplex virus keratitis: a non-contact photomicrographic study in vivo in the human cornea. ( 9686852 )
1998
45
Foscarnet eyedrops in recurrence prophylaxis of herpes simplex virus keratitis. ( 9881570 )
1998
46
Analysis of T cell receptor V beta gene expression in B cell deficient mice after experimental herpes simplex virus keratitis. ( 9385402 )
1997
47
Treatment of acyclovir-resistant herpes simplex virus keratitis in a patient with Wiskott-Aldrich syndrome. ( 9402402 )
1997
48
Herpes simplex virus keratitis among patients who are positive or negative for human immunodeficiency virus: an epidemiologic study. ( 9022115 )
1997
49
In vivo immunofluorescence to diagnose herpes simplex virus keratitis in mice. ( 9422934 )
1997
50
Newly acquired herpes simplex virus keratitis after penetrating keratoplasty. ( 9111258 )
1997

Variations for Herpes Simplex Virus Keratitis

Expression for Herpes Simplex Virus Keratitis

Search GEO for disease gene expression data for Herpes Simplex Virus Keratitis.

Pathways for Herpes Simplex Virus Keratitis

Pathways related to Herpes Simplex Virus Keratitis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 CCL2 CXCL8 ICAM1
2
Show member pathways
11.86 CCL2 CXCL8 ICAM1
3
Show member pathways
11.68 CCL2 CXCL8 ICAM1
4 11.62 CCL2 CXCL8 ICAM1
5 11.56 CXCL8 ICAM1
6 11.55 CCL2 CXCL8 ICAM1
7
Show member pathways
11.54 CXCL8 ICAM1
8 11.47 CXCL8 ICAM1
9 11.43 CCL2 CXCL8 ICAM1
10 11.34 CCL2 CXCL8
11
Show member pathways
11.32 CXCL8 ICAM1
12 11.29 CCL2 CXCL8 ICAM1
13
Show member pathways
11.27 CCL2 CXCL8
14 11.12 CXCL8 ICAM1
15 10.99 CCL2 CXCL8
16 10.83 CCL2 ICAM1
17 10.82 CCL2 CXCL8 ICAM1
18 10.61 CCL2 ICAM1
19 10.49 CCL2 CXCL8 ICAM1

GO Terms for Herpes Simplex Virus Keratitis

Biological processes related to Herpes Simplex Virus Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.54 CCL2 CXCL8 ICAM1
2 cellular response to interferon-gamma GO:0071346 9.48 CCL2 ICAM1
3 neutrophil chemotaxis GO:0030593 9.46 CCL2 CXCL8
4 chemokine-mediated signaling pathway GO:0070098 9.43 CCL2 CXCL8
5 cellular response to lipopolysaccharide GO:0071222 9.43 CCL2 CXCL8 ICAM1
6 regulation of cell adhesion GO:0030155 9.4 CXCL8 ICAM1
7 cellular response to fibroblast growth factor stimulus GO:0044344 9.32 CCL2 CXCL8
8 PERK-mediated unfolded protein response GO:0036499 9.16 CCL2 CXCL8
9 cellular response to tumor necrosis factor GO:0071356 9.13 CCL2 CXCL8 ICAM1
10 cellular response to interleukin-1 GO:0071347 8.8 CCL2 CXCL8 ICAM1

Molecular functions related to Herpes Simplex Virus Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CCL2 CXCL8

Sources for Herpes Simplex Virus Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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