MCID: HRP005
MIFTS: 28

Herpetic Whitlow

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Herpetic Whitlow

MalaCards integrated aliases for Herpetic Whitlow:

Name: Herpetic Whitlow 12 15 70
Herpetic Felon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8607
ICD9CM 34 054.6
NCIt 50 C128402
SNOMED-CT 67 43891009
UMLS 70 C0153042

Summaries for Herpetic Whitlow

Disease Ontology : 12 A herpes simplex that results in infection located in skin of the finger, toe, or thumb, has material basis in Human herpesvirus 1 and has material basis in Human herpesvirus 2 and has symptom lesions, has symptom fever, and has symptom swollen lymph nodes.

MalaCards based summary : Herpetic Whitlow, also known as herpetic felon, is related to lymphangitis and herpes simplex, and has symptoms including fever, lesions and swollen lymph nodes. An important gene associated with Herpetic Whitlow is SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5), and among its related pathways/superpathways is IgA-Producing B Cells in the Intestine. Affiliated tissues include skin of the finger and skin.

Wikipedia : 73 A herpetic whitlow is a lesion (whitlow) on a finger or thumb caused by the herpes simplex virus. It is... more...

Related Diseases for Herpetic Whitlow

Diseases related to Herpetic Whitlow via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 lymphangitis 30.6 SIGLEC5 CD4
2 herpes simplex 30.6 TNFRSF14 PILRA NECTIN1 ACKR1
3 genital herpes 29.9 TNFRSF14 NECTIN1 CD4 ACKR1
4 paronychia 10.4
5 cellulitis 10.3
6 paresthesia 10.2
7 salpingitis 10.1 SIGLEC5 CD4
8 tick infestation 10.1 SIGLEC5 CD4
9 intestinal schistosomiasis 10.1 SIGLEC5 CD4
10 fallopian tube disease 10.1 SIGLEC5 CD4
11 sialadenitis 10.1 SIGLEC5 CD4
12 streptococcus pneumonia 10.1 SIGLEC5 CD4
13 gingival disease 10.1 SIGLEC5 CD4
14 endocardium disease 10.1 SIGLEC5 CD4
15 splenic disease 10.1 SIGLEC5 CD4
16 herpes simplex virus keratitis 10.1 CD4 C21orf91
17 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 1 10.1 CD4 ACKR1
18 autoimmune disease of exocrine system 10.1 SIGLEC5 CD4
19 keratitis, hereditary 10.0
20 leukemia, chronic lymphocytic 10.0
21 li-fraumeni syndrome 10.0
22 erythema multiforme 10.0
23 squamous cell carcinoma 10.0
24 cheilitis 10.0
25 melanoma 10.0
26 acne 10.0
27 vasculitis 10.0
28 pompholyx 10.0
29 meningitis 10.0
30 stomatitis 10.0
31 tenosynovitis 10.0
32 diabetic neuropathy 10.0
33 anus disease 10.0 SIGLEC5 CD4
34 asymptomatic neurosyphilis 10.0 PILRA CD4
35 urethral syndrome 10.0 SIGLEC5 CD4
36 lymph node disease 10.0 SIGLEC5 CD4
37 parasitic helminthiasis infectious disease 10.0 SIGLEC5 CD4
38 salivary gland disease 10.0 SIGLEC5 CD4
39 parasitic protozoa infectious disease 10.0 SIGLEC5 CD4 ACKR1
40 ectodermal dysplasia 1, hypohidrotic, x-linked 9.9 NECTIN1 CD4
41 salmonellosis 9.9 SIGLEC5 CD4
42 microscopic polyangiitis 9.8 FCGR3B FCGR3A
43 transient neonatal neutropenia 9.8 FCGR3B FCGR3A
44 oxirane allergy 9.8 FCGR3B FCGR3A
45 chronic nk-cell lymphocytosis 9.8 FCGR3B FCGR3A
46 selective igg deficiency disease 9.8 FCGR3B FCGR3A
47 folliculitis 9.8 FCGR3A CD4
48 mosaic variegated aneuploidy syndrome 2 9.8 FCGR3B FCGR3A
49 acute retinal necrosis syndrome 9.8 TNFRSF14 SIGLEC5 NECTIN1 CD4
50 immunodeficiency 20 9.8 FCGR3B FCGR3A

Graphical network of the top 20 diseases related to Herpetic Whitlow:



Diseases related to Herpetic Whitlow

Symptoms & Phenotypes for Herpetic Whitlow

Symptoms:

12
  • fever
  • lesions
  • swollen lymph nodes

Drugs & Therapeutics for Herpetic Whitlow

Search Clinical Trials , NIH Clinical Center for Herpetic Whitlow

Genetic Tests for Herpetic Whitlow

Anatomical Context for Herpetic Whitlow

The Foundational Model of Anatomy Ontology organs/tissues related to Herpetic Whitlow:

19
Skin Of The Finger

MalaCards organs/tissues related to Herpetic Whitlow:

40
Skin

Publications for Herpetic Whitlow

Articles related to Herpetic Whitlow:

(show top 50) (show all 141)
# Title Authors PMID Year
1
Herpetic whitlow masquerading as pompholyx in a healthcare worker: revisiting the entity in today's era. 61
33650138 2021
2
Atypical paronychia: don't forget herpesvirus. 61
33560799 2021
3
Lymphangitis associated with herpetic whitlow. 61
31785802 2020
4
The Early Report of Herpetic Whitlow by Bahal-Dawlah Razi in 15th Century CE. 61
32920583 2020
5
Herpetic whitlow in a 39-year-old woman. 61
32868273 2020
6
[Herpetic whitlow - A neglected Diagnosis]. 61
32767290 2020
7
Herpetic whitlow in the course of combined immunosuppression. 61
31865394 2020
8
Gangrenous herpetic whitlow initially misdiagnosed as cellulitis. 61
32002986 2020
9
Herpetic whitlow mimicking squamous cell carcinoma in an immunocompromised patient. 61
31430400 2020
10
Case report: palmar herpetic whitlow and forearm lymphangitis in a 10-year-old female. 61
31752766 2019
11
Learning from Mistakes – a Case of Pediatric Patient with Recurrent Whitlow. 61
32337938 2019
12
Herpetic whitlow of the toe presenting with severe viral cellulitis. 61
30859616 2019
13
Acute Hand Infections. 61
30763047 2019
14
Herpetic Whitlow-A Case of Inadvertent Inoculation With Melanoma Viral Therapy. 61
30422160 2018
15
Complete Resolution of Mycobacterium marinum Infection with Clarithromycin and Ethambutol: A Case Report and a Review of the Literature. 61
30666280 2018
16
Herpetic Whitlow. 61
29414271 2018
17
MDCT of hand and wrist infections: emphasis on compartmental anatomy. 61
28065641 2017
18
Acral manifestations of viral infections. 61
27938811 2017
19
Atypical Herpetic Whitlow: A Diagnosis to Consider. 61
28376707 2017
20
Brincidofovir clearance of acyclovir-resistant herpes simplex virus-1 and adenovirus infection after stem cell transplantation. 61
27482652 2016
21
Chronic herpetic whitlow as the first manifestation of HIV infection. 61
27574796 2016
22
Blistering Distal Dactylitis in an Adult. 61
25775614 2015
23
Identification of ribonucleotide reductase mutation causing temperature-sensitivity of herpes simplex virus isolates from whitlow by deep sequencing. 61
26185649 2015
24
A man with an infected finger: a case report. 61
26001830 2015
25
Atypical presentation of herpetic whitlow as dark brown vesicles in a hyperbilirubinemic patient. 61
25066415 2015
26
[Paronychia]. 61
25441843 2014
27
Images in clinical medicine. Herpetic whitlow. 61
25337767 2014
28
Self-inflicted herpetic whitlow. 61
24729108 2014
29
Herpetic whitlow during immunosuppressive therapy for Wegener's Granulomatosis. 61
27708871 2014
30
Pediatric herpes simplex virus infections: an evidence-based approach to treatment. 61
24649621 2014
31
A Case Report of Herpetic Whitlow with Positive Kanavel's Cardinal Signs: A Diagnostic and Treatment Difficulty. 61
25436164 2014
32
Recurrent infection in the left thumb. 61
23649866 2013
33
Hand infections. 61
24095077 2013
34
Paediatric recurrent herpetic whitlow. 61
23904423 2013
35
Recurrent primary paediatric herpetic whitlow of the big toe. 61
23436893 2013
36
Herpetic whitlow. 61
22546886 2012
37
HSV-2 meningitis disseminated from a herpetic whitlow. 61
22595224 2012
38
Herpetic whitlow. 61
21918289 2011
39
Nail disorders in children: diagnosis and management. 61
21348541 2011
40
The herpetic whitlow. 61
21186084 2011
41
Nongenital herpes simplex virus. 61
21121552 2010
42
A case of herpetiform appearance of digital mucous cysts. 61
20548912 2010
43
[Investigation of herpes simplex virus (HSV) by three different methods in the clinical specimens of patients with suspected HSV infections]. 61
20455398 2010
44
A nurse practitioner's guide to the management of herpes simplex virus-1 in children. 61
19241742 2008
45
A nurse practitioner's guide to the management of herpes simplex virus-1 in children. 61
18814565 2008
46
[Herpetic whitlow: a forgotten occupational hazard]. 61
18423955 2008
47
[Herpetic recurrent upper limb lymphangitis]. 61
17980461 2008
48
Genital herpes due to acyclovir-sensitive herpes simplex virus caused secondary and recurrent herpetic whitlows due to thymidine kinase-deficient/temperature-sensitive virus. 61
17854045 2007
49
Production of recombinant gG-1 protein of herpes simplex virus type 1 in a prokaryotic system in order to develop a type-specific enzyme-linked immunosorbent assay kit. 61
17521395 2007
50
Herpetic whitlow. 61
17674583 2007

Variations for Herpetic Whitlow

Expression for Herpetic Whitlow

Search GEO for disease gene expression data for Herpetic Whitlow.

Pathways for Herpetic Whitlow

Pathways related to Herpetic Whitlow according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 FCGR3B FCGR3A

GO Terms for Herpetic Whitlow

Cellular components related to Herpetic Whitlow according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.56 TNFRSF14 SIGLEC5 PILRA NECTIN1 FCGR3B FCGR3A
2 plasma membrane GO:0005886 9.23 TNFRSF14 SIGLEC5 PILRA NECTIN1 FCGR3B FCGR3A

Biological processes related to Herpetic Whitlow according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.46 TNFRSF14 PILRA NECTIN1 CD4
2 regulation of immune response GO:0050776 9.43 PILRA FCGR3B FCGR3A
3 cell surface receptor signaling pathway GO:0007166 9.26 TNFRSF14 FCGR3B FCGR3A CD4
4 immune response GO:0006955 9.02 TNFRSF14 NECTIN1 FCGR3B FCGR3A CD4

Molecular functions related to Herpetic Whitlow according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.43 NECTIN1 CD4 ACKR1
2 coreceptor activity GO:0015026 9.32 NECTIN1 CD4
3 IgG binding GO:0019864 9.16 FCGR3B FCGR3A
4 virus receptor activity GO:0001618 9.13 TNFRSF14 NECTIN1 CD4
5 transmembrane signaling receptor activity GO:0004888 8.92 FCGR3B FCGR3A CD4 ACKR1

Sources for Herpetic Whitlow

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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