Hidradenitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HDR003 MIFTS: 46	Hidradenitis Categories: Skin diseases
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Aliases & Classifications for Hidradenitis

MalaCards integrated aliases for Hidradenitis:

Name: Hidradenitis ¹² ⁴⁴ ¹⁵ ⁷³

Hydradenitis ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2282

ICD9CM ³⁵ 705.83

MeSH ⁴⁴ D016575

NCIt ⁵⁰ C112190

SNOMED-CT ⁶⁸ 156417004 201204008 267814008 more

UMLS ⁷³ C0085160

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Summaries for Hidradenitis

MalaCards based summary : Hidradenitis, also known as hydradenitis, is related to pyoderma gangrenosum and pyoderma. An important gene associated with Hidradenitis is NCSTN (Nicastrin), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Adalimumab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and testes, and related phenotypes are craniofacial and hematopoietic system

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Related Diseases for Hidradenitis

Diseases related to Hidradenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)

#	Related Disease	Score	Top Affiliating Genes
1	pyoderma gangrenosum	30.9	NOD2 TNF
2	pyoderma	30.9	NOD2 TNF
3	spondyloarthropathy 1	29.6	IL17A NOD2 TNF
4	spondylitis	29.6	IL17A NOD2 TNF
5	colitis	29.5	IL17A NOD2 TNF
6	psoriasis	29.1	IL17A KRT10 KRT14 TNF
7	skin disease	28.7	IL17A KRT10 KRT14 TNF
8	hidradenitis suppurativa	27.3	DSC2 DSG2 IL12RB1 IL17A KRT10 KRT14
9	pyoderma gangrenosum-acne-suppurative hidradenitis syndrome	12.0
10	perifolliculitis capitis abscedens et suffodiens, familial	11.3
11	acne inversa, familial, 1	11.2
12	papillon-lefevre syndrome	10.9
13	acne inversa, familial, 2, with or without dowling-degos disease	10.9
14	acne inversa, familial, 3	10.9
15	sebaceous gland disease	10.7	NCSTN PSENEN
16	granulomatous dermatitis	10.6	NOD2 TNF
17	ileocolitis	10.6	NOD2 TNF
18	crohn's colitis	10.6	NOD2 TNF
19	ocular toxoplasmosis	10.5	IL17A NOD2
20	inflammatory bowel disease 3	10.5	NOD2 TNF
21	rheumatoid lung disease	10.5	IL17A TNF
22	orofacial granulomatosis	10.5	NOD2 TNF
23	trichosporonosis	10.5	IL17A TNF
24	streptococcal meningitis	10.5	NOD2 TNF
25	blau syndrome	10.5	NOD2 TNF
26	central nervous system vasculitis	10.5	IL17A TNF
27	transverse myelitis	10.4	IL17A TNF
28	primary systemic mycosis	10.4	IL17A TNF
29	anal canal squamous cell carcinoma	10.4	NCSTN PSEN1 PSENEN
30	myelitis	10.4	IL17A TNF
31	stromal keratitis	10.4	IL17A TNF
32	panuveitis	10.4	IL17A TNF
33	q fever	10.3	NOD2 TNF
34	joint disorders	10.3	IL17A TNF
35	hypersensitivity reaction type iv disease	10.3	NOD2 TNF
36	basal cell carcinoma, infundibulocystic	10.3	KRT10 KRT14
37	filamentary keratitis	10.3	IL17A KRT10
38	large cell acanthoma	10.3	KRT10 KRT14
39	epidermolysis bullosa simplex with mottled pigmentation	10.3	KRT10 KRT14
40	striate palmoplantar keratoderma	10.3	KRT10 KRT14
41	breast squamous cell carcinoma	10.3	KRT10 KRT14
42	cutaneous candidiasis	10.2	IL12RB1 IL17A
43	epidermolysis bullosa simplex, dowling-meara type	10.2	KRT10 KRT14
44	squamous cell carcinoma	10.2
45	acute graft versus host disease	10.2	NOD2 TNF
46	crohn's disease	10.2
47	extrinsic cardiomyopathy	10.2	IL17A TNF
48	inflammatory bowel disease 6	10.2	IL12RB1 NOD2
49	ichthyosis vulgaris	10.2	KRT10 KRT14
50	ileitis	10.2	IL17A NOD2 TNF

Graphical network of the top 20 diseases related to Hidradenitis:

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Symptoms & Phenotypes for Hidradenitis

MGI Mouse Phenotypes related to Hidradenitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.35	IL17A KRT14 NCSTN PSEN1 TNF
2	hematopoietic system	MP:0005397	9.17	IL12RB1 IL17A KRT14 NCSTN NOD2 PSEN1

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Drugs & Therapeutics for Hidradenitis

Drugs for Hidradenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Adalimumab

Approved

Phase 4,Phase 3,Phase 2

331731-18-1

16219006

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Antirheumatic Agents

Phase 4,Phase 3,Phase 2,Phase 1

Anesthetics

Phase 4,Phase 1

Anti-Bacterial Agents

Phase 3,Phase 2,Not Applicable

Antibiotics, Antitubercular

Phase 3,Not Applicable

Apremilast

Approved, Investigational

Phase 2

608141-41-9

11561674

Infliximab

Approved

Phase 2

170277-31-3

Etanercept

Approved, Investigational

Phase 2

185243-69-0

Ustekinumab

Approved, Investigational

Phase 2

815610-63-0

Hydroxychloroquine

Approved

Phase 1, Phase 2

118-42-3

3652

Drospirenone

Approved

Phase 2

67392-87-4

68873

Estradiol

Approved, Investigational, Vet_approved

Phase 2

50-28-2

5757

Estradiol valerate

Approved, Investigational, Vet_approved

Phase 2

979-32-8

Ethinyl Estradiol

Approved

Phase 2

57-63-6

5991

Polyestradiol phosphate

Approved

Phase 2

28014-46-2

Anti-Infective Agents

Phase 2,Phase 1,Not Applicable

Immunosuppressive Agents

Phase 2,Not Applicable

Dermatologic Agents

Phase 2,Not Applicable

Hormone Antagonists

Phase 2,Not Applicable

Hormones

Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2,Not Applicable

Antibodies

Phase 2,Phase 1,Early Phase 1

Antibodies, Monoclonal

Phase 2,Phase 1,Early Phase 1

Immunoglobulins

Phase 2,Phase 1,Early Phase 1

Analgesics

Phase 2

Analgesics, Non-Narcotic

Phase 2

Angiogenesis Inhibitors

Phase 2

Angiogenesis Modulating Agents

Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 2

Peripheral Nervous System Agents

Phase 2,Not Applicable

Interleukin 1 Receptor Antagonist Protein

Phase 2

Gastrointestinal Agents

Phase 2

Complement System Proteins

Phase 2

Antimalarials

Phase 1, Phase 2

Antiparasitic Agents

Phase 1, Phase 2

Antiprotozoal Agents

Phase 1, Phase 2

Contraceptive Agents

Phase 2

Contraceptives, Oral

Phase 2

diuretics

Phase 2

Diuretics, Potassium Sparing

Phase 2

Drospirenone and ethinyl estradiol combination

Phase 2

Estradiol 17 beta-cypionate

Phase 2

Estradiol 3-benzoate

Phase 2

Estrogens

Phase 2

Mineralocorticoid Receptor Antagonists

Phase 2

Mineralocorticoids

Phase 2

Natriuretic Agents

Phase 2

Phenol

Approved, Experimental

Phase 1

108-95-2

996

Pharmaceutical Solutions

Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 60)

#	Name	Status	NCT ID	Phase	Drugs
1	Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study)	Recruiting	NCT02808975	Phase 4	Adalimumab;Placebo
2	Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS	Not yet recruiting	NCT03221621	Phase 4	Adalimumab Injection
3	Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa	Completed	NCT01468207	Phase 3
4	Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa	Completed	NCT01468233	Phase 3
5	Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa	Completed	NCT01635764	Phase 3
6	Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa	Recruiting	NCT02805595	Phase 3	23.4% Hypertonic saline;Saline
7	Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa	Active, not recruiting	NCT02904902	Phase 3	Adalimumab
8	To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis Suppurativa	Terminated	NCT00367328	Phase 3
9	Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients	Completed	NCT02421172	Phase 2
10	Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa	Completed	NCT02695212	Phase 2	Apremilast
11	To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa	Completed	NCT00827996	Phase 2	adalimumab
12	Anakinra as a Treatment for Hydradenitis Suppurativa	Completed	NCT01516749	Phase 2	anakinra
13	Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa	Completed	NCT00795574	Phase 2	infliximab;Placebo Comparator
14	Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa	Completed	NCT03001622	Phase 2
15	Etanercept in Hidradenitis Suppurativa	Completed	NCT00329823	Phase 2	Etanercept sc 50mg per week for 12 weeks
16	Anakinra in Hidradenitis Suppurativa	Completed	NCT01558375	Phase 2	Water for injection;Anakinra
17	Etanercept for Treatment of Hidradenitis	Completed	NCT00107991	Phase 2	etanercept
18	MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB	Completed	NCT02643654	Phase 2	MABp1;Placebo
19	A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa	Completed	NCT01704534	Phase 2	Ustekinumab
20	Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis	Completed	NCT03049267	Phase 2	Apremilast;Placebo Oral Tablet
21	Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa	Completed	NCT00918255	Phase 2	Placebo
22	A Study of MABp1 in Patients With Hidradenitis Suppurativa	Recruiting	NCT03512275	Phase 2	MABp1 Monoclonal Antibody 200 mg;MABp1 Monoclonal Antibody 400 mg
23	Efficacy and Safety Study of IFX-1 in Patients With Moderate to Severe Hidradenitis Suppurativa (HS)	Recruiting	NCT03487276	Phase 2	IFX-1;Placebo
24	Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa	Recruiting	NCT03275870	Phase 1, Phase 2	Hydroxychloroquine
25	A Study to Test the Efficacy, Safety and Pharmacokinetics of Bimekizumab in Subjects With Moderate to Severe Hidradenitis Suppurativa.	Active, not recruiting	NCT03248531	Phase 2	Bimekizumab;Adalimumab
26	A Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa	Not yet recruiting	NCT03569371	Phase 2	INCB054707
27	Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa	Terminated	NCT01838499	Phase 2
28	A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS	Terminated	NCT00722800	Phase 2	drospirenone and ethinyl estradiol (YAZ);Placebo
29	Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis Suppurativa	Completed	NCT00134134	Phase 1	efalizumab
30	Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol	Completed	NCT02277340	Phase 1
31	An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa.	Unknown status	NCT01818167	Not Applicable	10% Benzoyl Peroxide Topical Body Wash;Provodine Topical Cream
32	Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing	Unknown status	NCT02163746	Not Applicable
33	Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa	Unknown status	NCT01063270	Not Applicable	Clindamycin & Rifampin
34	Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary Fistula	Unknown status	NCT01315080
35	A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.	Completed	NCT02781818	Not Applicable	Triamcinolone Acetonide 10mg/mL;Triamcinolone Acetonide 40mg/mL;Normal Saline
36	Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa	Completed	NCT00494351	Not Applicable
37	Post Marketing Observational Study (PMOS) to Assess Quality of Life in Swedish Hidradenitis Suppurativa (HS) Patients	Completed	NCT02739828
38	Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients	Completed	NCT02833909	Not Applicable
39	Quality of Life After Wide Surgical Excision in Patients With Hidradenitis Suppurativa	Completed	NCT02593604
40	A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa	Completed	NCT00395187	Not Applicable
41	Treatment of Hidradenitis Suppurativa Using Etanercept	Completed	NCT00949546		etanercept
42	Treatment of Hidradenitis Suppurativa With Eth 755nm Alexandrite Laser	Recruiting	NCT03054155	Not Applicable
43	Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects	Recruiting	NCT03001115
44	A National Registry For Patients With Hidradenitis Suppurativa	Recruiting	NCT03289585
45	Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of Life	Recruiting	NCT02904408	Not Applicable
46	Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa	Recruiting	NCT03040804	Not Applicable
47	Exploratory Trial Evaluating Cosentyx (Secukinumab) for Patients With Moderate-to-Severe Hidradenitis Suppurativa	Recruiting	NCT03099980	Early Phase 1
48	Hidradenitis Suppurativa and Periodontal Diseases	Recruiting	NCT03553888
49	Impact of Hidradenitis Suppurativa on Quality of Life Functions	Recruiting	NCT03288337
50	The Ohio State University Dermatology Biorepository, Molecular Biology and Genetics of Hidradenitis Suppurativa	Recruiting	NCT03146676

Search NIH Clinical Center for Hidradenitis

Cochrane evidence based reviews: hidradenitis

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Genetic Tests for Hidradenitis

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Anatomical Context for Hidradenitis

MalaCards organs/tissues related to Hidradenitis:

⁴¹

Neutrophil, Skin, Testes, Thyroid, Myeloid, Pituitary, Monocytes

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Publications for Hidradenitis

Articles related to Hidradenitis:

(show top 50) (show all 794)

#	Title	Authors	Year
1	The in-hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014. ( 29431201 )	Ramos-Rodriguez A.J....Lemor A.	2018
2	Distinguishing Mild, Moderate, and Severe Hidradenitis Suppurativa. ( 29926079 )	Kokolakis G....Sabat R.	2018
3	Incidence of Obstructive Sleep Apnea among Patients with Hidradenitis Suppurativa: a retrospective population-based cohort analysis. ( 29957857 )	Wertenteil S....Garg A.	2018
4	Safety of Adalimumab Dosed Every Week and Every Other Week: Focus on Patients with Hidradenitis Suppurativa or Psoriasis. ( 29380251 )	Ryan C....Hendrickson B.A.	2018
5	The immunological disease continuum of inflammation against self as an explanation for the lack of association between hidradenitis suppurativa and autoimmune thyroid disease. ( 29327479 )	De Vita V....Mcgonagle D.	2018
6	Acne and hidradenitis suppurativa. ( 29380349 )	Pink A....Navarini A.A.	2018
7	Combined fractional carbon dioxide laser and long-pulsed neodymium : yttrium-aluminium-garnet (1064 nm) laser in treatment of hidradenitis suppurativa; a prospective randomized intra-individual controlled study. ( 29907956 )	Abdel Azim A.A....Abdelghani R.	2018
8	Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 2. ( 29363099 )	Vekic D.A....Cains G.D.	2018
9	Current and future treatment of hidradenitis suppurativa. ( 29981245 )	van Straalen K.R....Prens E.P.	2018
10	Laser hair removal alters the disease course in mild hidradenitis suppurativa. ( 29933519 )	Vossen A.R.J.V....Prens E.P.	2018
11	Concurrent hidradenitis suppurativa and Dowling-Degos disease taken down a 'Notch'. ( 29441533 )	McGrath J.A.	2018
12	Hidradenitis suppurativa is associated with polycystic ovary syndrome: a population-based analysis in the United States. ( 29378201 )	Garg A....Strunk A.	2018
13	Anti-TNFI+ therapy modulates mTORC1signalling in hidradenitis suppurativa. ( 29956847 )	Balato A....Fabbrocini G.	2018
14	Acquired lymphangioma circumscriptum of the genitals in an individual with chronic hidradenitis suppurativa. ( 29387752 )	Piernick D.M....Daveluy S.	2018
15	Women with Hidradenitis Suppurativa Have an Elevated Risk of Suicide. ( 29959906 )	Tiri H....Tasanen K.	2018
16	Longitudinal observational study of hidradenitis suppurativa: impact of surgical intervention with adjunctive biologic therapy. ( 29130482 )	Shanmugam V.K....Amdur R.	2018
17	Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 1. ( 29355905 )	Vekic D.A....Cains G.D.	2018
18	Surgical management of hidradenitis suppurativa: procedural trends and risk factors. ( 29936991 )	Ruan Q.Z....Fukudome E.Y.	2018
19	Secondary gastrointestinal amyloid A amyloidosis possibly caused by hidradenitis suppurativa. ( 29933503 )	Kochi S....Kurahara K.	2018
20	Distinguishing Mild, Moderate, and Severe Hidradenitis Suppurativa. ( 29926084 )	Hessam S....Bechara F.G.	2018
21	Radical resection and local coverage of hidradenitis suppurativa - acne inversa: analysis of results. ( 29924129 )	Mendes R.R.D.S....Gemperli R.	2018
22	Risk Factors for Hidradenitis Suppurativa in Patients with Inflammatory Bowel Disease. ( 29357084 )	Lukach A.J....Swoger J.M.	2018
23	Blood parameters in a population of blood donors are not affected by hidradenitis suppurativa. ( 29952294 )	Theut Riis P....Jemec G.	2018
24	Comment on &quot;Hidradenitis suppurativa in children treated with finasteride-A case series&quot;. ( 29356110 )	Abdelmaksoud A.	2018
25	A case of pyoderma gangrenosum, acne, hidradenitis suppurativa (PASH) syndrome associated with diabetes mellitus type 1 treated with adalimumab. ( 29368847 )	Fattore D....Bongiorno M.R.	2018
26	Patients affected by Dent disease 2 could be predisposed to hidradenitis suppurativa. ( 29430722 )	Marzuillo P....La Manna A.	2018
27	A Novel Severity Assessment Scoring System for Hidradenitis Suppurativa. ( 29417136 )	Hessam S....Bechara F.G.	2018
28	Squamous cell carcinoma of the perineum masquerading as necrotizing hidradenitis suppurativa. ( 29906008 )	Harview C.L....Hsiao J.L.	2018
29	A case of Axillary Hidradenitis suppurativa treated with topical tacrolimus. ( 29368858 )	Marasca C....Fabbrocini G.	2018
30	Growing evidence for coronary artery disease risk factors in patients with severe hidradenitis suppurativa. ( 29357611 )	Cohen A.D....Zisman D.	2018
31	Congenital nevus comedonicus complicated by a hidradenitis suppurativa-like lesion: Report of a childhood case. ( 29952017 )	Ravaioli G.M....Patrizi A.	2018
32	Reliability of the hidradenitis suppurativa clinical response (HiSCR) in the assessment of patients with hidradenitis suppurativa. ( 29959796 )	Kimball A.B....Fleischer A.	2018
33	The effect of oral clindamycin and rifampicin combination therapy in patients with hidradenitis suppurativa in Singapore. ( 29403298 )	Ochi H....Oon H.H.	2018
34	Hidradenitis Suppurativa in Kuala Lumpur, Malaysia: A 7-Year Retrospective Review. ( 29951091 )	Ahmad Kamil M.A....Mohd Affandi A.	2018
35	Prevalence of Type II Diabetes Mellitus Among Patients with Hidradenitis Suppurativa in the United States. ( 29339240 )	Garg A....Strunk A.	2018
36	Aggravation of mild axillary hidradenitis suppurativa by microwave ablation: results of a randomized intra-patient controlled trial. ( 29940205 )	Vossen A.R.J.V....Prens E.P.	2018
37	HIDRAdisk: an innovative visual tool to assess the burden of hidradenitis suppurativa. ( 29894009 )	Chiricozzi A....Atzori L.	2018
38	Drug-induced sarcoidosis in a patient treated with an interleukin-1 receptor antagonist for hidradenitis suppurativa. ( 29892670 )	Friedman B.E....English J.C.	2018
39	Hidradenitis suppurativa with SAPHO syndrome maintained effectively with adalimumab, methotrexate, and intralesional corticosteroid injections. ( 29922466 )	Crowley E.L....Gooderham M.J.	2018
40	Complement activation in hidradenitis suppurativa: a new pathway of pathogenesis? ( 29405257 )	Kanni T....Giamarellos-Bourboulis E.J.	2018
41	Quality of Life and Psychosocial Implications in Patients with Hidradenitis Suppurativa. ( 28052274 )	Kouris A....Kontochristopoulos G.	2017
42	Weekly adalimumab significantly reduces the number of abscesses and inflammatory nodules in patients with moderate to severe hidradenitis suppurativa. ( 28053204 )	Mekkes J.	2017
43	Interferon-gamma (IFN-I^) is Elevated in Wound Exudate from Hidradenitis Suppurativa. ( 27819528 )	Banerjee A....Shanmugam V.K.	2017
44	Glucagon-like peptide-1 agonists for treatment of hidradenitis suppurativa. ( 28940285 )	Emtestam L....Sartorius K.	2017
45	Increased Suicide Risk in Patients with Hidradenitis Suppurativa. ( 28942360 )	Thorlacis L....Egeberg A.	2017
46	Disseminate recurrent folliculitis as the presenting picture of hidradenitis suppurativa. ( 28838562 )	Revuz J.	2017
47	Novel POFUT1 mutation associated with hidradenitis suppurativa-Dowling-Degos disease firm up a role for Notch signalling in the pathogenesis of this disorder. ( 29274243 )	GonzA!lez-Villanueva I....Pascual J.C.	2017
48	Body fat composition in hidradenitis suppurativa: a hospital-based cross-sectional study. ( 28084004 )	RomanA- J....Luelmo J.	2017
49	Hidradenitis Suppurativa in Down Syndrome: A Case Series. ( 28636122 )	Hamadah I....Binamer Y.	2017
50	Prevalence and risk of inflammatory bowel disease in patients with hidradenitis suppurativa. ( 28089682 )	Egeberg A....Mallbris L.	2017

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Genes for Hidradenitis

Genes related to Hidradenitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NCSTN	Nicastrin	Protein Coding	25.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	23.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	TNF	Tumor Necrosis Factor	Protein Coding	22.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	IL17A	Interleukin 17A	Protein Coding	22.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	PSEN1	Presenilin 1	Protein Coding	21.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	21.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	KRT14	Keratin 14	Protein Coding	20.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	KRT10	Keratin 10	Protein Coding	20.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	20.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	DSC2	Desmocollin 2	Protein Coding	20.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	DSG2	Desmoglein 2	Protein Coding	20.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Hidradenitis

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Expression for Hidradenitis

Search GEO for disease gene expression data for Hidradenitis.

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Pathways for Hidradenitis

Pathways related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.01	DSC2 DSG2 KRT10 KRT14 NCSTN PSENEN
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.21	DSC2 DSG2 KRT10 KRT14
3	Th17 cell differentiation ³⁷ Show member pathways Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.16	IL12RB1 IL17A NOD2 TNF
4	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ IL-6-type cytokine receptor ligand interactions ⁶⁶ Interleukin-6 family signaling ⁶⁶ Interleukin-6 signaling ⁶⁶ Th17 Differentiation Pathway ⁶⁵	12	IL12RB1 IL17A TNF
5	Wnt / Hedgehog / Notch ⁴	11.97	NCSTN PSEN1 PSENEN
6	Development NOTCH1-mediated pathway for NF-KB activity modulation ²² Show member pathways Development Notch Signaling Pathway ²² Transcription Sin3 and NuRD in transcription regulation ²²	11.93	NCSTN PSEN1 PSENEN
7	Presenilin-Mediated Signaling ⁶⁴	11.82	NCSTN PSEN1 PSENEN
8	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.56	IL12RB1 IL17A TNF
9	p75(NTR)-mediated signaling ¹ Show member pathways Ceramide signalling ⁶⁶ NFG and proNGF binds to p75NTR ⁶⁶	11.4	NCSTN PSEN1 PSENEN
10	A-beta Signaling Pathways ⁶⁵	11.24	NCSTN PSEN1 PSENEN
11	Development and heterogeneity of the ILC family ¹	11.06	IL17A TNF
12	Presenilin action in Notch and Wnt signaling ¹	10.99	NCSTN PSEN1 PSENEN
13	Canonical NF-kappaB pathway ¹	10.87	NOD2 TNF
14	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁵	10.49	NCSTN PSEN1 PSENEN
15	Notch Pathway ⁷²	10.07	PSEN1 PSENEN
16	Syndecan-3-mediated signaling events ¹	10.03	NCSTN PSEN1 PSENEN

Sources

GO Terms for Hidradenitis

Cellular components related to Hidradenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.56	DSG2 NOD2 PSEN1 TNF
2	desmosome	GO:0030057	9.16	DSC2 DSG2
3	cornified envelope	GO:0001533	9.13	DSC2 DSG2 KRT10
4	gamma-secretase complex	GO:0070765	8.8	NCSTN PSEN1 PSENEN

Biological processes related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of apoptotic process	GO:0043065	9.86	NCSTN PSEN1 PSENEN TNF
2	keratinization	GO:0031424	9.76	DSC2 DSG2 KRT10 KRT14
3	Notch signaling pathway	GO:0007219	9.75	NCSTN PSEN1 PSENEN
4	cornification	GO:0070268	9.73	DSC2 DSG2 KRT10 KRT14
5	positive regulation of catalytic activity	GO:0043085	9.71	NCSTN PSEN1 PSENEN
6	ephrin receptor signaling pathway	GO:0048013	9.7	NCSTN PSEN1 PSENEN
7	protein processing	GO:0016485	9.69	NCSTN PSEN1 PSENEN
8	positive regulation of MAP kinase activity	GO:0043406	9.65	NOD2 PSEN1 TNF
9	regulation of heart rate by cardiac conduction	GO:0086091	9.62	DSC2 DSG2
10	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.61	NOD2 TNF
11	positive regulation of interleukin-8 production	GO:0032757	9.61	NOD2 TNF
12	positive regulation of osteoclast differentiation	GO:0045672	9.6	IL17A TNF
13	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.59	IL17A NOD2
14	amyloid-beta metabolic process	GO:0050435	9.58	NCSTN PSEN1
15	membrane protein ectodomain proteolysis	GO:0006509	9.58	NCSTN PSEN1 PSENEN
16	epithelial cell proliferation	GO:0050673	9.57	NCSTN PSEN1
17	regulation of ventricular cardiac muscle cell action potential	GO:0098911	9.55	DSC2 DSG2
18	membrane protein intracellular domain proteolysis	GO:0031293	9.54	NCSTN PSEN1 PSENEN
19	Notch receptor processing	GO:0007220	9.5	NCSTN PSEN1 PSENEN
20	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	GO:0086073	9.49	DSC2 DSG2
21	Notch receptor processing, ligand-dependent	GO:0035333	9.43	NCSTN PSEN1 PSENEN
22	amyloid precursor protein metabolic process	GO:0042982	9.33	NCSTN PSEN1 PSENEN
23	amyloid precursor protein catabolic process	GO:0042987	9.13	NCSTN PSEN1 PSENEN
24	amyloid-beta formation	GO:0034205	8.8	NCSTN PSEN1 PSENEN

Molecular functions related to Hidradenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	GO:0086083	8.62	DSC2 DSG2

Sources

Sources for Hidradenitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

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³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁵ R&D Systems

⁶⁶ Reactome

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⁶⁸ SNOMED-CT

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⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia