Hidradenitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HDR003 MIFTS: 47	Hidradenitis Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Hidradenitis

MalaCards integrated aliases for Hidradenitis:

Name: Hidradenitis ¹² ⁴⁴ ¹⁵ ⁷³

Hydradenitis ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2282

ICD9CM ³⁵ 705.83

MeSH ⁴⁴ D016575

NCIt ⁵⁰ C112190

SNOMED-CT ⁶⁸ 69741000

UMLS ⁷³ C0085160

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Summaries for Hidradenitis

MalaCards based summary : Hidradenitis, also known as hydradenitis, is related to hidradenitis suppurativa and pyoderma. An important gene associated with Hidradenitis is NCSTN (Nicastrin), and among its related pathways/superpathways are Developmental Biology and Th17 cell differentiation. The drugs Adalimumab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and thyroid, and related phenotypes are craniofacial and hematopoietic system

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Related Diseases for Hidradenitis

Diseases related to Hidradenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)

#	Related Disease	Score	Top Affiliating Genes
1	hidradenitis suppurativa	32.1	DSC2 DSG2 IL12RB1 IL17A KRT10 KRT14
2	pyoderma	30.9	NOD2 TNF
3	pyoderma gangrenosum	30.9	NOD2 TNF
4	arthritis	30.3	IL17A NOD2 TNF
5	psoriasis	30.2	IL17A KRT10 KRT14 TNF
6	crohn's colitis	30.2	NOD2 TNF
7	colitis	30.1	IL17A NOD2 TNF
8	ulcerative colitis	30.1	IL17A NOD2 TNF
9	dowling-degos disease	30.0	DSC2 KRT14 NCSTN PSENEN
10	spondyloarthropathy 1	29.9	IL17A NOD2 TNF
11	spondylitis	29.9	IL17A NOD2 TNF
12	spondylarthropathy	29.8	NOD2 TNF
13	melkersson-rosenthal syndrome	29.7	NOD2 TNF
14	skin disease	29.7	IL17A KRT10 KRT14 TNF
15	pyoderma gangrenosum-acne-suppurative hidradenitis syndrome	12.2
16	perifolliculitis capitis abscedens et suffodiens, familial	11.4
17	acne inversa, familial, 1	11.3
18	papillon-lefevre syndrome	11.1
19	acne inversa, familial, 2, with or without dowling-degos disease	11.0
20	acne inversa, familial, 3	11.0
21	squamous cell carcinoma	10.5
22	neurofibromatosis, type ii	10.5
23	crohn's disease	10.4
24	inflammatory bowel disease	10.3
25	sebaceous gland disease	10.2	NCSTN PSENEN
26	dowling-degos disease 1	10.2
27	malignant atrophic papulosis	10.2
28	miller fisher syndrome	10.2	PSENEN TNF
29	ileocolitis	10.2	NOD2 TNF
30	granulomatous dermatitis	10.2	NOD2 TNF
31	streptococcal meningitis	10.2	NOD2 TNF
32	inflammatory bowel disease 3	10.2	NOD2 TNF
33	ocular toxoplasmosis	10.2	IL17A NOD2
34	orofacial granulomatosis	10.2	NOD2 TNF
35	trichosporonosis	10.2	IL17A TNF
36	rheumatoid lung disease	10.2	IL17A TNF
37	central nervous system vasculitis	10.2	IL17A TNF
38	down syndrome	10.2
39	cellulitis	10.2
40	blau syndrome	10.2	NOD2 TNF
41	sweat gland disease	10.2	KRT14 NCSTN
42	autoimmune disease of eyes, ear, nose and throat	10.1	IL17A TNF
43	transverse myelitis	10.1	IL17A TNF
44	myelitis	10.1	IL17A TNF
45	primary systemic mycosis	10.1	IL17A TNF
46	anal canal squamous cell carcinoma	10.1	NCSTN PSEN1 PSENEN
47	mycoplasma pneumoniae pneumonia	10.1	IL17A TNF
48	stromal keratitis	10.1	IL17A TNF
49	amyloidosis	10.1
50	joint disorders	10.1	IL17A TNF

Graphical network of the top 20 diseases related to Hidradenitis:

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Symptoms & Phenotypes for Hidradenitis

MGI Mouse Phenotypes related to Hidradenitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.55	IL17A KRT14 NCSTN PSEN1 TNF
2	hematopoietic system	MP:0005397	9.5	IL12RB1 IL17A KRT14 NCSTN NOD2 PSEN1
3	immune system	MP:0005387	9.17	IL12RB1 IL17A KRT14 NCSTN NOD2 PSEN1

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Drugs & Therapeutics for Hidradenitis

Drugs for Hidradenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Adalimumab

Approved

Phase 4,Phase 3,Phase 2

331731-18-1

16219006

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Antirheumatic Agents

Phase 4,Phase 3,Phase 2,Phase 1

Anesthetics

Phase 4,Phase 1

Immunologic Factors

Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Bacterial Agents

Phase 3,Phase 2,Not Applicable

Antibiotics, Antitubercular

Phase 3,Not Applicable

Antibodies, Monoclonal

Phase 3,Phase 2,Phase 1,Early Phase 1

Immunoglobulins

Phase 3,Phase 2,Phase 1,Early Phase 1

Antibodies

Phase 3,Phase 2,Phase 1,Early Phase 1

Apremilast

Approved, Investigational

Phase 2

608141-41-9

11561674

Infliximab

Approved

Phase 2

170277-31-3

Etanercept

Approved, Investigational

Phase 2

185243-69-0

Ustekinumab

Approved, Investigational

Phase 2

815610-63-0

Hydroxychloroquine

Approved

Phase 1, Phase 2

118-42-3

3652

Ethinyl Estradiol

Approved

Phase 2

57-63-6

5991

Estradiol

Approved, Investigational, Vet_approved

Phase 2

50-28-2

5757

Polyestradiol phosphate

Approved

Phase 2

28014-46-2

Drospirenone

Approved

Phase 2

67392-87-4

68873

Estradiol valerate

Approved, Investigational, Vet_approved

Phase 2

979-32-8

Immunosuppressive Agents

Phase 2,Not Applicable

Anti-Infective Agents

Phase 2,Phase 1,Not Applicable

Dermatologic Agents

Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2,Not Applicable

Hormones

Phase 2,Not Applicable

Hormone Antagonists

Phase 2,Not Applicable

Angiogenesis Modulating Agents

Phase 2

Peripheral Nervous System Agents

Phase 2,Not Applicable

Analgesics

Phase 2

Analgesics, Non-Narcotic

Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 2

Angiogenesis Inhibitors

Phase 2

Interleukin 1 Receptor Antagonist Protein

Phase 2

Gastrointestinal Agents

Phase 2

Complement System Proteins

Phase 2

Antiparasitic Agents

Phase 1, Phase 2

Antimalarials

Phase 1, Phase 2

Antiprotozoal Agents

Phase 1, Phase 2

Contraceptives, Oral

Phase 2

Diuretics, Potassium Sparing

Phase 2

Estrogens

Phase 2

Estradiol 3-benzoate

Phase 2

Contraceptive Agents

Phase 2

Mineralocorticoids

Phase 2

Drospirenone and ethinyl estradiol combination

Phase 2

diuretics

Phase 2

Mineralocorticoid Receptor Antagonists

Phase 2

Natriuretic Agents

Phase 2

Estradiol 17 beta-cypionate

Phase 2

Phenol

Approved, Experimental

Phase 1

108-95-2

996

Interventional clinical trials:

(show top 50) (show all 69)

#	Name	Status	NCT ID	Phase	Drugs
1	Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study)	Recruiting	NCT02808975	Phase 4	Adalimumab;Placebo
2	Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS	Not yet recruiting	NCT03221621	Phase 4	Adalimumab Injection
3	Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa	Completed	NCT01468207	Phase 3
4	Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa	Completed	NCT01468233	Phase 3
5	Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa	Completed	NCT01635764	Phase 3
6	Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa	Recruiting	NCT02805595	Phase 3	23.4% Hypertonic saline;Saline
7	Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa	Active, not recruiting	NCT02904902	Phase 3	Adalimumab
8	Study of Efficacy and Safety of Two Secukinumab Dose Regimens in Subjects With Moderate to Severe Hidradenitis Suppurativa (HS)	Not yet recruiting	NCT03713632	Phase 3	Secukinumab;Placebo
9	This is a Study of Efficacy and Safety of Two Secukinumab Dose Regimens in Subjects With Moderate to Severe Hidradenitis Suppurativa (HS).	Not yet recruiting	NCT03713619	Phase 3	secukinumab;placebo
10	To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis Suppurativa	Terminated	NCT00367328	Phase 3
11	Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients	Completed	NCT02421172	Phase 2
12	Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa	Completed	NCT02695212	Phase 2	Apremilast
13	To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa	Completed	NCT00827996	Phase 2	adalimumab
14	Anakinra as a Treatment for Hydradenitis Suppurativa	Completed	NCT01516749	Phase 2	anakinra
15	Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa	Completed	NCT00795574	Phase 2	infliximab;Placebo Comparator
16	Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa	Completed	NCT03001622	Phase 2
17	Etanercept in Hidradenitis Suppurativa	Completed	NCT00329823	Phase 2	Etanercept sc 50mg per week for 12 weeks
18	Etanercept for Treatment of Hidradenitis	Completed	NCT00107991	Phase 2	etanercept
19	Anakinra in Hidradenitis Suppurativa	Completed	NCT01558375	Phase 2	Water for injection;Anakinra
20	MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB	Completed	NCT02643654	Phase 2	MABp1;Placebo
21	A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa	Completed	NCT01704534	Phase 2	Ustekinumab
22	Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis	Completed	NCT03049267	Phase 2	Apremilast;Placebo Oral Tablet
23	Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa	Completed	NCT00918255	Phase 2	Placebo
24	A Study of Bermekimab in Patients With Hidradenitis Suppurativa	Recruiting	NCT03512275	Phase 2	Bermekimab Monoclonal Antibody 400 mg
25	A Study to Evaluate the Efficacy, Safety, and Tolerability of Guselkumab for the Treatment of Participants With Moderate to Severe Hidradenitis Suppurativa (HS)	Recruiting	NCT03628924	Phase 2	Guselkumab dose 1;Guselkumab dose 2;Guselkumab dose 3;Placebo
26	A Placebo-Controlled Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa	Recruiting	NCT03607487	Phase 2	INCB054707;Placebo
27	A Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa	Recruiting	NCT03569371	Phase 2	INCB054707
28	Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa	Recruiting	NCT03275870	Phase 1, Phase 2	Hydroxychloroquine
29	A Study to Test the Efficacy, Safety and Pharmacokinetics of Bimekizumab in Subjects With Moderate to Severe Hidradenitis Suppurativa.	Active, not recruiting	NCT03248531	Phase 2	Bimekizumab;Adalimumab
30	Efficacy and Safety Study of IFX-1 in Patients With Moderate to Severe Hidradenitis Suppurativa (HS)	Active, not recruiting	NCT03487276	Phase 2	IFX-1;Placebo
31	Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa	Terminated	NCT01838499	Phase 2
32	A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS	Terminated	NCT00722800	Phase 2	drospirenone and ethinyl estradiol (YAZ);Placebo
33	Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis Suppurativa	Completed	NCT00134134	Phase 1	efalizumab
34	Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol	Completed	NCT02277340	Phase 1
35	Patients With Hidradenitis vs Patients With Psoriasis: Psychological Impact	Unknown status	NCT02999698
36	An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa.	Unknown status	NCT01818167	Not Applicable	10% Benzoyl Peroxide Topical Body Wash;Provodine Topical Cream
37	Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of Life	Unknown status	NCT02904408	Not Applicable
38	Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing	Unknown status	NCT02163746	Not Applicable
39	Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa	Unknown status	NCT01063270	Not Applicable	Clindamycin & Rifampin
40	Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary Fistula	Unknown status	NCT01315080
41	Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting	Completed	NCT02786576
42	Association Between Hidradenitis Suppurativa and Spondyloarthritis	Completed	NCT03668925	Not Applicable
43	A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.	Completed	NCT02781818	Not Applicable	Triamcinolone Acetonide 10mg/mL;Triamcinolone Acetonide 40mg/mL;Normal Saline
44	Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa	Completed	NCT00494351	Not Applicable
45	Pilot Study on Botulinum Toxin B as Treatment for Hidradenitis Suppurativa	Completed	NCT03103074	Not Applicable	Botulinum B Toxin
46	Post Marketing Observational Study (PMOS) to Assess Quality of Life in Swedish Hidradenitis Suppurativa (HS) Patients	Completed	NCT02739828
47	Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients	Completed	NCT02833909	Not Applicable
48	Quality of Life After Wide Surgical Excision in Patients With Hidradenitis Suppurativa	Completed	NCT02593604
49	Nutritional Status and Hidradenitis Suppurativa (Acne Inversa)	Completed	NCT03683238
50	A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa	Completed	NCT00395187	Not Applicable

Search NIH Clinical Center for Hidradenitis

Cochrane evidence based reviews: hidradenitis

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Genetic Tests for Hidradenitis

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Anatomical Context for Hidradenitis

MalaCards organs/tissues related to Hidradenitis:

⁴¹

Skin, Neutrophil, Thyroid, Ovary, Myeloid, Lung, Eye

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Publications for Hidradenitis

Articles related to Hidradenitis:

(show top 50) (show all 1474)

#	Title	Authors	Year
1	Apremilast for moderate hidradenitis suppurativa: Results of a randomized controlled trial. ( 30482392 )	Vossen ARJV...Prens EP	2019
2	Adolescent-Onset Hidradenitis Suppurativa: Prevalence, Risk Factors and Disease Features. ( 30368494 )	Molina-Leyva A...Cuenca-Barrales C	2019
3	Standardized Photographic Documentation of Hidradenitis Suppurativa/Acne Inversa. ( 30368496 )	Zouboulis CC...Nogueira da Costa A	2019
4	The in-hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014. ( 29431201 )	Ramos-Rodriguez A.J....Lemor A.	2018
5	Distinguishing Mild, Moderate, and Severe Hidradenitis Suppurativa. ( 29926079 )	Kokolakis G....Sabat R.	2018
6	Incidence of Obstructive Sleep Apnea among Patients with Hidradenitis Suppurativa: a retrospective population-based cohort analysis. ( 29957857 )	Wertenteil S....Garg A.	2018
7	Safety of Adalimumab Dosed Every Week and Every Other Week: Focus on Patients with Hidradenitis Suppurativa or Psoriasis. ( 29380251 )	Ryan C....Hendrickson B.A.	2018
8	The immunological disease continuum of inflammation against self as an explanation for the lack of association between hidradenitis suppurativa and autoimmune thyroid disease. ( 29327479 )	De Vita V....Mcgonagle D.	2018
9	Acne and hidradenitis suppurativa. ( 29380349 )	Pink A....Navarini A.A.	2018
10	Combined fractional carbon dioxide laser and long-pulsed neodymium : yttrium-aluminium-garnet (1064 nm) laser in treatment of hidradenitis suppurativa; a prospective randomized intra-individual controlled study. ( 29907956 )	Abdel Azim A.A....Abdelghani R.	2018
11	Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 2. ( 29363099 )	Vekic D.A....Cains G.D.	2018
12	Current and future treatment of hidradenitis suppurativa. ( 29981245 )	van Straalen K.R....Prens E.P.	2018
13	Laser hair removal alters the disease course in mild hidradenitis suppurativa. ( 29933519 )	Vossen A.R.J.V....Prens E.P.	2018
14	Concurrent hidradenitis suppurativa and Dowling-Degos disease taken down a 'Notch'. ( 29441533 )	McGrath J.A.	2018
15	Hidradenitis suppurativa is associated with polycystic ovary syndrome: a population-based analysis in the United States. ( 29378201 )	Garg A....Strunk A.	2018
16	Anti-TNFI+ therapy modulates mTORC1signalling in hidradenitis suppurativa. ( 29956847 )	Balato A....Fabbrocini G.	2018
17	Acquired lymphangioma circumscriptum of the genitals in an individual with chronic hidradenitis suppurativa. ( 29387752 )	Piernick D.M....Daveluy S.	2018
18	Women with Hidradenitis Suppurativa Have an Elevated Risk of Suicide. ( 29959906 )	Tiri H....Tasanen K.	2018
19	Longitudinal observational study of hidradenitis suppurativa: impact of surgical intervention with adjunctive biologic therapy. ( 29130482 )	Shanmugam V.K....Amdur R.	2018
20	Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 1. ( 29355905 )	Vekic D.A....Cains G.D.	2018
21	Surgical management of hidradenitis suppurativa: procedural trends and risk factors. ( 29936991 )	Ruan Q.Z....Fukudome E.Y.	2018
22	Secondary gastrointestinal amyloid A amyloidosis possibly caused by hidradenitis suppurativa. ( 29933503 )	Kochi S....Kurahara K.	2018
23	Distinguishing Mild, Moderate, and Severe Hidradenitis Suppurativa. ( 29926084 )	Hessam S....Bechara F.G.	2018
24	Radical resection and local coverage of hidradenitis suppurativa - acne inversa: analysis of results. ( 29924129 )	Mendes R.R.D.S....Gemperli R.	2018
25	Risk Factors for Hidradenitis Suppurativa in Patients with Inflammatory Bowel Disease. ( 29357084 )	Lukach A.J....Swoger J.M.	2018
26	Blood parameters in a population of blood donors are not affected by hidradenitis suppurativa. ( 29952294 )		2018
27	Comment on &quot;Hidradenitis suppurativa in children treated with finasteride-A case series&quot;. ( 29356110 )		2018
28	A case of pyoderma gangrenosum, acne, hidradenitis suppurativa (PASH) syndrome associated with diabetes mellitus type 1 treated with adalimumab. ( 29368847 )		2018
29	Patients affected by Dent disease 2 could be predisposed to hidradenitis suppurativa. ( 29430722 )		2018
30	A Novel Severity Assessment Scoring System for Hidradenitis Suppurativa. ( 29417136 )		2018
31	Squamous cell carcinoma of the perineum masquerading as necrotizing hidradenitis suppurativa. ( 29906008 )		2018
32	A case of Axillary Hidradenitis suppurativa treated with topical tacrolimus. ( 29368858 )		2018
33	Growing evidence for coronary artery disease risk factors in patients with severe hidradenitis suppurativa. ( 29357611 )		2018
34	Congenital nevus comedonicus complicated by a hidradenitis suppurativa-like lesion: Report of a childhood case. ( 29952017 )		2018
35	Reliability of the hidradenitis suppurativa clinical response (HiSCR) in the assessment of patients with hidradenitis suppurativa. ( 29959796 )		2018
36	The effect of oral clindamycin and rifampicin combination therapy in patients with hidradenitis suppurativa in Singapore. ( 29403298 )		2018
37	Hidradenitis Suppurativa in Kuala Lumpur, Malaysia: A 7-Year Retrospective Review. ( 29951091 )		2018
38	Prevalence of Type II Diabetes Mellitus Among Patients with Hidradenitis Suppurativa in the United States. ( 29339240 )		2018
39	Aggravation of mild axillary hidradenitis suppurativa by microwave ablation: results of a randomized intra-patient controlled trial. ( 29940205 )		2018
40	HIDRAdisk: an innovative visual tool to assess the burden of hidradenitis suppurativa. ( 29894009 )		2018
41	Drug-induced sarcoidosis in a patient treated with an interleukin-1 receptor antagonist for hidradenitis suppurativa. ( 29892670 )		2018
42	Hidradenitis suppurativa with SAPHO syndrome maintained effectively with adalimumab, methotrexate, and intralesional corticosteroid injections. ( 29922466 )		2018
43	Hidradenitis suppurativa in a patient with hyperandrogenism, insulin-resistance and acanthosis nigricans (HAIR-AN syndrome). ( 29991979 )	Melibary YT	2018
44	Alexithymia affects patients with hidradenitis suppurativa. ( 30325328 )	Chiricozzi A...Peris K	2018
45	To what extent do disease severity and illness perceptions explain depression, anxiety and quality of life in hidradenitis suppurativa? ( 30171696 )	Pavon Blanco A...Weinman J	2018
46	Acute fatty liver of pregnancy in a woman with ulcerative colitis and familial hidradenitis suppurativa. ( 30214481 )	Morton A	2018
47	Prevalence and Description of Hidradenitis Suppurativa in Down Syndrome: A Cross-sectional Study of 783 Subjects. ( 30460373 )	Poizeau F...Hotz C	2018
48	Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis. ( 29689550 )	Giovanardi G...Peris K	2018
49	Prevalence of hidradenitis suppurativa among patients with Down syndrome: a population-based cross-sectional analysis. ( 28662304 )	Garg A...Pomerantz H	2018
50	Severe refractory hidradenitis suppurativa successfully treated with adalimumab in an HIV-positive/hepatitis C virus-positive patient. ( 30281563 )	Molina-Leyva A...Badiola J	2018

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Genes for Hidradenitis

Genes related to Hidradenitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NCSTN	Nicastrin	Protein Coding	25.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	23.15	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	TNF	Tumor Necrosis Factor	Protein Coding	22.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	IL17A	Interleukin 17A	Protein Coding	22.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	PSEN1	Presenilin 1	Protein Coding	21.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	20.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	KRT14	Keratin 14	Protein Coding	20.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	KRT10	Keratin 10	Protein Coding	20.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	19.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	DSC2	Desmocollin 2	Protein Coding	19.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	DSG2	Desmoglein 2	Protein Coding	19.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Hidradenitis

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Expression for Hidradenitis

Search GEO for disease gene expression data for Hidradenitis.

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Pathways for Hidradenitis

Pathways related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.01	DSC2 DSG2 KRT10 KRT14 NCSTN PSENEN
2	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.32	IL12RB1 IL17A NOD2 TNF
3	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.19	DSC2 DSG2 KRT10 KRT14
4	Wnt / Hedgehog / Notch ⁴	11.98	NCSTN PSEN1 PSENEN
5	Development NOTCH1-mediated pathway for NF-KB activity modulation ²² Show member pathways Development Notch Signaling Pathway ²² Transcription Sin3 and NuRD in transcription regulation ²²	11.94	NCSTN PSEN1 PSENEN
6	Presenilin-Mediated Signaling ⁶⁴	11.84	NCSTN PSEN1 PSENEN
7	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.78	IL12RB1 IL17A TNF
8	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.54	IL12RB1 IL17A TNF
9	p75(NTR)-mediated signaling ¹ Show member pathways Ceramide signalling ⁶⁶ NFG and proNGF binds to p75NTR ⁶⁶	11.4	NCSTN PSEN1 PSENEN
10	A-beta Signaling Pathways ⁶⁵	11.24	NCSTN PSEN1 PSENEN
11	Development and heterogeneity of the ILC family ¹	11.06	IL17A TNF
12	Presenilin action in Notch and Wnt signaling ¹	10.99	NCSTN PSEN1 PSENEN
13	Canonical NF-kappaB pathway ¹	10.89	NOD2 TNF
14	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁵	10.49	NCSTN PSEN1 PSENEN
15	Notch Pathway ⁷²	10.07	PSEN1 PSENEN
16	Syndecan-3-mediated signaling events ¹	10.03	NCSTN PSEN1 PSENEN

Sources

GO Terms for Hidradenitis

Cellular components related to Hidradenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.56	DSG2 NOD2 PSEN1 TNF
2	desmosome	GO:0030057	9.16	DSC2 DSG2
3	cornified envelope	GO:0001533	9.13	DSC2 DSG2 KRT10
4	gamma-secretase complex	GO:0070765	8.8	NCSTN PSEN1 PSENEN

Biological processes related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	Notch signaling pathway	GO:0007219	9.74	NCSTN PSEN1 PSENEN
2	keratinization	GO:0031424	9.73	DSC2 DSG2 KRT10 KRT14
3	positive regulation of catalytic activity	GO:0043085	9.69	NCSTN PSEN1 PSENEN
4	cornification	GO:0070268	9.67	DSC2 DSG2 KRT10 KRT14
5	positive regulation of MAP kinase activity	GO:0043406	9.65	NOD2 PSEN1 TNF
6	protein processing	GO:0016485	9.63	NCSTN PSEN1 PSENEN
7	regulation of heart rate by cardiac conduction	GO:0086091	9.61	DSC2 DSG2
8	positive regulation of interleukin-8 production	GO:0032757	9.6	NOD2 TNF
9	regulation of synaptic transmission, glutamatergic	GO:0051966	9.59	PSEN1 TNF
10	positive regulation of osteoclast differentiation	GO:0045672	9.58	IL17A TNF
11	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.58	IL17A NOD2
12	membrane protein ectodomain proteolysis	GO:0006509	9.58	NCSTN PSEN1 PSENEN
13	amyloid-beta metabolic process	GO:0050435	9.56	NCSTN PSEN1
14	epithelial cell proliferation	GO:0050673	9.55	NCSTN PSEN1
15	regulation of ventricular cardiac muscle cell action potential	GO:0098911	9.54	DSC2 DSG2
16	astrocyte activation	GO:0048143	9.52	PSEN1 TNF
17	amyloid precursor protein metabolic process	GO:0042982	9.5	NCSTN PSEN1 PSENEN
18	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	GO:0086073	9.49	DSC2 DSG2
19	Notch receptor processing	GO:0007220	9.43	NCSTN PSEN1 PSENEN
20	amyloid precursor protein catabolic process	GO:0042987	9.33	NCSTN PSEN1 PSENEN
21	Notch receptor processing, ligand-dependent	GO:0035333	9.13	NCSTN PSEN1 PSENEN
22	amyloid-beta formation	GO:0034205	8.8	NCSTN PSEN1 PSENEN

Molecular functions related to Hidradenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	GO:0086083	8.62	DSC2 DSG2

Sources

Sources for Hidradenitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia