MCID: HDR003
MIFTS: 52

Hidradenitis

Categories: Endocrine diseases, Skin diseases

Aliases & Classifications for Hidradenitis

MalaCards integrated aliases for Hidradenitis:

Name: Hidradenitis 12 45 15 74
Hydradenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2282
ICD9CM 36 705.83
MeSH 45 D016575
NCIt 51 C112190
SNOMED-CT 69 69741000
UMLS 74 C0085160

Summaries for Hidradenitis

Disease Ontology : 12 A sweat gland disease that is characterized by inflammation of the apocrine sweat glands and has symptom erythema, edema, papules, plaques, pruritis, and pain.

MalaCards based summary : Hidradenitis, also known as hydradenitis, is related to hidradenitis suppurativa and pyoderma, and has symptoms including erythema An important gene associated with Hidradenitis is NCSTN (Nicastrin), and among its related pathways/superpathways are Developmental Biology and Th17 cell differentiation. The drugs Adalimumab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and myeloid, and related phenotypes are growth/size/body region and digestive/alimentary

Wikipedia : 77 Hidradenitis is any disease in which the histologic abnormality is primarily an inflammatory infiltrate... more...

Related Diseases for Hidradenitis

Diseases related to Hidradenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 hidradenitis suppurativa 31.3 DSC2 DSG2 IL12RB1 IL17A KRT10 KRT14
2 pyoderma 31.0 NOD2 TNF
3 pyoderma gangrenosum 31.0 NOD2 TNF
4 crohn's colitis 30.8 NOD2 TNF
5 inflammatory bowel disease 30.5 IL17A NOD2 TNF
6 joint disorders 30.2 IL17A TNF
7 colitis 30.2 IL17A NOD2 TNF
8 ulcerative colitis 30.2 IL17A NOD2 TNF
9 dowling-degos disease 30.1 DSC2 KRT14 NCSTN PSENEN
10 spondyloarthropathy 1 30.0 IL17A NOD2 TNF
11 spondylitis 30.0 IL17A NOD2 TNF
12 spondylarthropathy 30.0 NOD2 TNF
13 skin disease 29.8 IL17A KRT10 KRT14 TNF
14 melkersson-rosenthal syndrome 29.8 NOD2 TNF
15 sarcoidosis 1 29.6 IL12RB1 NOD2 TNF
16 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 12.3
17 acne inversa, familial, 1 11.7
18 perifolliculitis capitis abscedens et suffodiens, familial 11.4
19 acne inversa, familial, 2, with or without dowling-degos disease 11.4
20 papillon-lefevre syndrome 11.1
21 pyogenic sterile arthritis, pyoderma gangrenosum, and acne 11.1
22 acne inversa, familial, 3 11.1
23 neurofibromatosis, type ii 10.7
24 squamous cell carcinoma 10.6
25 crohn's disease 10.5
26 psoriasis 10.4
27 sebaceous gland disease 10.4 NCSTN PSENEN
28 miller fisher syndrome 10.3 PSENEN TNF
29 ocular toxoplasmosis 10.3 IL17A NOD2
30 ileocolitis 10.3 NOD2 TNF
31 granulomatous dermatitis 10.3 NOD2 TNF
32 trichosporonosis 10.3 IL17A TNF
33 inflammatory bowel disease 3 10.3 NOD2 TNF
34 streptococcal meningitis 10.3 NOD2 TNF
35 central nervous system vasculitis 10.3 IL17A TNF
36 orofacial granulomatosis 10.3 NOD2 TNF
37 arthritis 10.3
38 autoimmune disease of eyes, ear, nose and throat 10.3 IL17A TNF
39 sweat gland disease 10.2 KRT14 NCSTN
40 transverse myelitis 10.2 IL17A TNF
41 myelitis 10.2 IL17A TNF
42 anal canal squamous cell carcinoma 10.2 NCSTN PSEN1 PSENEN
43 primary systemic mycosis 10.2 IL17A TNF
44 dowling-degos disease 1 10.2
45 malignant atrophic papulosis 10.2
46 mycoplasma pneumoniae pneumonia 10.2 IL17A TNF
47 blau syndrome 10.2 NOD2 TNF
48 filamentary keratitis 10.2 IL17A KRT10
49 stromal keratitis 10.2 IL17A TNF
50 pustulosis of palm and sole 10.2

Graphical network of the top 20 diseases related to Hidradenitis:



Diseases related to Hidradenitis

Symptoms & Phenotypes for Hidradenitis

Symptoms:

12
  • erythema

MGI Mouse Phenotypes related to Hidradenitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 DROSHA IL12RB1 IL17A KRT14 NCSTN NOD2
2 digestive/alimentary MP:0005381 9.8 DROSHA IL17A KRT14 NOD2 PSEN1 TNF
3 craniofacial MP:0005382 9.77 IL17A KRT14 NCSTN PSEN1 TNF
4 hematopoietic system MP:0005397 9.76 DROSHA IL12RB1 IL17A KRT14 NCSTN NOD2
5 immune system MP:0005387 9.56 DROSHA IL12RB1 IL17A KRT14 NCSTN NOD2
6 mortality/aging MP:0010768 9.28 DROSHA DSG2 IL17A KRT14 NCSTN NOD2

Drugs & Therapeutics for Hidradenitis

Drugs for Hidradenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2 331731-18-1 16219006
2 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Anesthetics Phase 4,Phase 1
4 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
5 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
6 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable
7 Antibiotics, Antitubercular Phase 3,Not Applicable
8 Antibodies Phase 3,Phase 2,Phase 1,Early Phase 1
9 Immunoglobulins Phase 3,Phase 2,Phase 1,Early Phase 1
10 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1,Early Phase 1
11
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
12
Infliximab Approved Phase 2 170277-31-3
13
Etanercept Approved, Investigational Phase 2 185243-69-0
14
Ustekinumab Approved, Investigational Phase 2 815610-63-0
15
Hydroxychloroquine Approved Phase 1, Phase 2 118-42-3 3652
16 Brodalumab Approved, Investigational Phase 2 1174395-19-7
17
Polyestradiol phosphate Approved Phase 2 28014-46-2
18
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
19
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
20
Drospirenone Approved Phase 2 67392-87-4 68873
21
Glutamic Acid Approved, Nutraceutical Phase 2 56-86-0 33032
22
Proline Approved, Nutraceutical Phase 2 147-85-3 145742
23 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
24 Immunosuppressive Agents Phase 2,Not Applicable
25 Dermatologic Agents Phase 2,Not Applicable
26 Pharmaceutical Solutions Phase 2,Phase 1,Not Applicable
27 Hormones Phase 2,Not Applicable
28 Hormone Antagonists Phase 2,Not Applicable
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
30 Analgesics Phase 2
31 Analgesics, Non-Narcotic Phase 2
32 Anti-Inflammatory Agents, Non-Steroidal Phase 2
33 Angiogenesis Inhibitors Phase 2
34 Angiogenesis Modulating Agents Phase 2
35 Peripheral Nervous System Agents Phase 2,Not Applicable
36 Interleukin 1 Receptor Antagonist Protein Phase 2
37 Gastrointestinal Agents Phase 2
38 Complement System Proteins Phase 2
39 lysine Phase 2
40 Antimalarials Phase 1, Phase 2
41 Antiprotozoal Agents Phase 1, Phase 2
42 Antiparasitic Agents Phase 1, Phase 2
43 Epidiolex Phase 2
44 Olive Phase 2
45 chlorophyllin Phase 2
46 Contraceptives, Oral Phase 2
47 Mineralocorticoid Receptor Antagonists Phase 2
48 Contraceptive Agents Phase 2
49 Natriuretic Agents Phase 2
50 Drospirenone and ethinyl estradiol combination Phase 2

Interventional clinical trials:

(show top 50) (show all 77)
# Name Status NCT ID Phase Drugs
1 Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS Recruiting NCT03221621 Phase 4 Adalimumab Injection
2 Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study) Active, not recruiting NCT02808975 Phase 4 Adalimumab;Placebo
3 Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa Completed NCT01468207 Phase 3
4 Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01468233 Phase 3
5 Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa Completed NCT01635764 Phase 3
6 Study of Efficacy and Safety of Two Secukinumab Dose Regimens in Subjects With Moderate to Severe Hidradenitis Suppurativa (HS) Recruiting NCT03713632 Phase 3 Secukinumab
7 This is a Study of Efficacy and Safety of Two Secukinumab Dose Regimens in Subjects With Moderate to Severe Hidradenitis Suppurativa (HS). Recruiting NCT03713619 Phase 3 secukinumab
8 Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa Recruiting NCT02805595 Phase 3 23.4% Hypertonic saline;Saline
9 Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa Active, not recruiting NCT02904902 Phase 3 adalimumab
10 To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis Suppurativa Terminated NCT00367328 Phase 3
11 A Study to Test the Efficacy, Safety and Pharmacokinetics of Bimekizumab in Subjects With Moderate to Severe Hidradenitis Suppurativa. Completed NCT03248531 Phase 2 Bimekizumab;Adalimumab
12 Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients Completed NCT02421172 Phase 2 Placebo
13 Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa Completed NCT02695212 Phase 2 Apremilast
14 To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa Completed NCT00827996 Phase 2 adalimumab
15 Anakinra as a Treatment for Hydradenitis Suppurativa Completed NCT01516749 Phase 2 anakinra
16 Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa Completed NCT00795574 Phase 2 infliximab;Placebo Comparator
17 Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa Completed NCT03001622 Phase 2
18 Etanercept in Hidradenitis Suppurativa Completed NCT00329823 Phase 2 Etanercept sc 50mg per week for 12 weeks
19 Etanercept for Treatment of Hidradenitis Completed NCT00107991 Phase 2 etanercept
20 Anakinra in Hidradenitis Suppurativa Completed NCT01558375 Phase 2 Water for injection;Anakinra
21 MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB Completed NCT02643654 Phase 2 MABp1;Placebo
22 A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa Completed NCT01704534 Phase 2 Ustekinumab
23 Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis Completed NCT03049267 Phase 2 Apremilast;Placebo Oral Tablet
24 Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa Completed NCT00918255 Phase 2 Placebo
25 Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa Recruiting NCT03827798 Phase 2 CFZ533;Placebo to CFZ533;LYS006;Placebo to LYS006
26 A Study of Bermekimab in Patients With Hidradenitis Suppurativa Recruiting NCT03512275 Phase 2 Bermekimab Monoclonal Antibody 400 mg
27 Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa Recruiting NCT03852472 Phase 2 Avacopan
28 A Study to Evaluate the Efficacy, Safety, and Tolerability of Guselkumab for the Treatment of Participants With Moderate to Severe Hidradenitis Suppurativa (HS) Recruiting NCT03628924 Phase 2 Guselkumab dose 1;Guselkumab dose 2;Guselkumab dose 3;Placebo
29 A Placebo-Controlled Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa Recruiting NCT03607487 Phase 2 INCB054707;Placebo
30 Efficacy and Safety Study of IFX-1 in Patients With Moderate to Severe Hidradenitis Suppurativa (HS) Active, not recruiting NCT03487276 Phase 2 IFX-1;Placebo
31 A Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa Active, not recruiting NCT03569371 Phase 2 INCB054707
32 Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa Active, not recruiting NCT03275870 Phase 1, Phase 2 Hydroxychloroquine
33 A Global Study Comparing Risankizumab to Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Not yet recruiting NCT03926169 Phase 2 Risankizumab;Placebo for risankizumab
34 Treatment of Moderate Hidradenitis Suppurativa Not yet recruiting NCT03910803 Phase 2 Brodalumab
35 Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa Not yet recruiting NCT03929835 Phase 2 Cannabis oil;Placebo
36 Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa Terminated NCT01838499 Phase 2
37 A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS Terminated NCT00722800 Phase 2 drospirenone and ethinyl estradiol (YAZ);Placebo
38 Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis Suppurativa Completed NCT00134134 Phase 1 efalizumab
39 Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol Completed NCT02277340 Phase 1
40 Patients With Hidradenitis vs Patients With Psoriasis: Psychological Impact Unknown status NCT02999698
41 An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa. Unknown status NCT01818167 Not Applicable 10% Benzoyl Peroxide Topical Body Wash;Provodine Topical Cream
42 Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing Unknown status NCT02163746 Not Applicable
43 Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of Life Unknown status NCT02904408 Not Applicable
44 Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa Unknown status NCT01063270 Not Applicable Clindamycin & Rifampin
45 Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary Fistula Unknown status NCT01315080
46 Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting Completed NCT02786576
47 Association Between Hidradenitis Suppurativa and Spondyloarthritis Completed NCT03668925 Not Applicable
48 A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa. Completed NCT02781818 Not Applicable Triamcinolone Acetonide 10mg/mL;Triamcinolone Acetonide 40mg/mL;Normal Saline
49 Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa Completed NCT00494351 Not Applicable
50 Pilot Study on Botulinum Toxin B as Treatment for Hidradenitis Suppurativa Completed NCT03103074 Not Applicable Botulinum B Toxin

Search NIH Clinical Center for Hidradenitis

Cochrane evidence based reviews: hidradenitis

Genetic Tests for Hidradenitis

Anatomical Context for Hidradenitis

MalaCards organs/tissues related to Hidradenitis:

42
Neutrophil, Skin, Myeloid, Thyroid, Testes, Breast, Lung

Publications for Hidradenitis

Articles related to Hidradenitis:

(show top 50) (show all 1818)
# Title Authors Year
1
To what extent do disease severity and illness perceptions explain depression, anxiety and quality of life in hidradenitis suppurativa? ( 30171696 )
2019
2
Depression in Hidradenitis Suppurativa. ( 31099413 )
2019
3
The associations of depression and coping methods on health-related quality of life for those with hidradenitis suppurativa. ( 30876533 )
2019
4
Hidradenitis suppurativa and diabetes mellitus: updated systematic review and adjusted meta-analysis. ( 30730068 )
2019
5
Prevalence and Description of Hidradenitis Suppurativa in Down Syndrome: A Cross-sectional Study of 783 Subjects. ( 30460373 )
2019
6
Non-Pharmacologic Approaches for Hidradenitis Suppurativa - A Systematic Review. ( 31106609 )
2019
7
E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions. ( 31107992 )
2019
8
Hidradenitis Suppurativa and Botulinum Toxin Type a Therapy: Two Cases. ( 30693648 )
2019
9
Association Between Hidradenitis Suppurativa and Lymphoma. ( 30698627 )
2019
10
Biologics for hidradenitis suppurativa: an update. ( 30702012 )
2019
11
Could isotretinoin flare hidradenitis suppurativa? A case series. ( 30719727 )
2019
12
Abstracts of the 8th European Hidradenitis Suppurativa Foundation (EHSF) Conference, 6-8 February 2019, Wrocław, Poland. ( 30723943 )
2019
13
Interrater agreement and reliability of outcome measurement instruments and staging systems used in hidradenitis suppurativa. ( 30724351 )
2019
14
Preoperative Ultrasound for Evaluation of Hidradenitis Suppurativa. ( 30726198 )
2019
15
Overall and subgroup prevalence of pyoderma gangrenosum among patients with hidradenitis suppurativa: A population-based analysis in the United States. ( 30738122 )
2019
16
Secukinumab and hidradenitis suppurativa: Friends or foes? ( 30740502 )
2019
17
Understanding the long diagnostic delay for hidradenitis suppurativa: a national survey among French general practitioners. ( 30761989 )
2019
18
Korean gender differences in hidradenitis suppuratva: nature or nurture? ( 30767281 )
2019
19
Response to "Korean gender differences in hidradenitis suppurativa: nature or nurture?" ( 30767325 )
2019
20
Hidradenitis Suppurativa as a Systemic Disease: Association With Metabolic Syndrome. ( 30797524 )
2019
21
Exophytic Mass Arising Within Hidradenitis Suppurativa: Answer. ( 30801344 )
2019
22
Open-label, Investigator-Initiated, Single Site Exploratory Trial Evaluating Secukinumab, an anti IL17A monoclonal antibody, for Patients with Moderate-to-Severe Hidradenitis Suppurativa. ( 30801662 )
2019
23
Virulent Staphylococcus lugdunensis with limited genetic diversity in hidradenitis suppurativa lesions. ( 30801776 )
2019
24
Exophytic Mass Arising Within Hidradenitis Suppurativa: Challenge. ( 30802225 )
2019
25
Isotretinoin and Hidradenitis Suppurativa. ( 30802991 )
2019
26
Hidradenitis Suppurativa and Diabetes: Big Data Bias Masks a True Association. ( 30802992 )
2019
27
Combination hyperbaric oxygen therapy and ustekinumab for severe hidradenitis suppurativa. ( 30805965 )
2019
28
Apremilast for the Treatment of Mild-to-Moderate Hidradenitis Suppurativa in a Prospective, Open-Label, Phase 2 Study ( 30811140 )
2019
29
Effectiveness, safety and tolerability of drainage and punch-trocar-assisted cryoinsufflation (cryopunch) in the treatment of inflammatory acute fluid collections in hidradenitis suppurativa patients. ( 30811686 )
2019
30
Reply to: "Could Isotretinoin flare Hidradentis suppurativa? A Case Series". ( 30816560 )
2019
31
Two-step surgery in extensive anogenital hidradenitis: What kind of faecal management? ( 30821118 )
2019
32
Squamous carcinoma over perineal hidradenitis suppurativa. ( 30825999 )
2019
33
Transcriptome patterns in hidradenitis suppurativa: support for the role of antimicrobial peptides and interferon pathways in disease pathogenesis. ( 30828847 )
2019
34
A new Th-17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26. ( 30829398 )
2019
35
Hidradenitis Suppurativa (Hurley I/II): Serial Excisions with Primary Wound Closure Under Local Anesthesia As Most Adequate Treatment Approach. ( 30834010 )
2019
36
Association Between Hidradenitis Suppurativa and Metabolic Syndrome. ( 30846164 )
2019
37
Topical, systemic and biologic therapies in hidradenitis suppurativa: pathogenic insights by examining therapeutic mechanisms. ( 30854183 )
2019
38
Commentary: Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model. ( 30858850 )
2019
39
North American Clinical Management Guidelines for Hidradenitis Suppurativa: a Publication from the United States and Canadian Hidradenitis Suppurativa Foundations. Part II: Topical, Intralesional, and Systemic medical Management. ( 30872149 )
2019
40
Comment on "Interruption of oral clindamycin plus rifampicin therapy in patients with hidradenitis suppurativa: an observational study to assess prevalence and causes". ( 30872151 )
2019
41
Reply to "Comment on 'Interruption of oral clindamycin plus rifampicin therapy in patients with hidradenitis suppurativa: an observational study to assess prevalence and causes' ". ( 30872153 )
2019
42
North American Clinical Management Guidelines for Hidradenitis Suppurativa: a Publication from the United States and Canadian Hidradenitis Suppurativa Foundations. Part I: Diagnosis, Evaluation, and the use of Complementary and Procedural Management. ( 30872156 )
2019
43
Lack of photographic documentation undermines assessment of hidradenitis suppurativa phenotypes. ( 30874297 )
2019
44
Assessing the Efficacy of New Biologic Therapies in Hidradenitis Suppurativa Consistency vs Bias in Outcome Measures in Moderate and Severe Disease. ( 30875132 )
2019
45
Reply to comment: guselkumab in the treatment of severe hidradenitis suppurativa. ( 30875137 )
2019
46
Mast cells in hidradenitis suppurativa: a clinicopathological study. ( 30877368 )
2019
47
Treatment of Hidradenitis Suppurativa with Extensive Resection of the Lesion and Coverage with Perforator Flaps of the Lateral Thoracic Wall (Lateral Thoracic Artery, Thoracodorsal Artery Perforators). ( 30881834 )
2019
48
Hidradenitis Suppurativa: Estimated Prevalence, Clinical Features, Concomitant Conditions, and Diagnostic Delay in a University Teaching Hospital in Buenos Aires, Argentina. ( 30885385 )
2019
49
Commentary on Squamous Cell Carcinoma in Perineal, Perianal, and Gluteal Hidradenitis Suppurativa: Experience in 12 Patients. ( 30893153 )
2019
50
Defining Fistular Patterns in Hidradenitis Suppurativa: Impact in the Management. ( 30893168 )
2019

Variations for Hidradenitis

Expression for Hidradenitis

Search GEO for disease gene expression data for Hidradenitis.

Pathways for Hidradenitis

Pathways related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 DSC2 DSG2 KRT10 KRT14 NCSTN PSENEN
2
Show member pathways
12.32 IL12RB1 IL17A NOD2 TNF
3
Show member pathways
12.21 DSC2 DSG2 KRT10 KRT14
4 11.98 NCSTN PSEN1 PSENEN
5
Show member pathways
11.94 NCSTN PSEN1 PSENEN
6 11.84 NCSTN PSEN1 PSENEN
7
Show member pathways
11.78 IL12RB1 IL17A TNF
8 11.51 IL12RB1 IL17A TNF
9
Show member pathways
11.4 NCSTN PSEN1 PSENEN
10 11.17 NCSTN PSEN1 PSENEN
11 11.06 IL17A TNF
12 10.99 NCSTN PSEN1 PSENEN
13 10.89 NOD2 TNF
14 10.49 NCSTN PSEN1 PSENEN
15 10.07 PSEN1 PSENEN
16 10.03 NCSTN PSEN1 PSENEN

GO Terms for Hidradenitis

Cellular components related to Hidradenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 DSG2 NOD2 PSEN1 TNF
2 desmosome GO:0030057 9.16 DSC2 DSG2
3 cornified envelope GO:0001533 9.13 DSC2 DSG2 KRT10
4 gamma-secretase complex GO:0070765 8.8 NCSTN PSEN1 PSENEN

Biological processes related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.75 NCSTN PSEN1 PSENEN
2 keratinization GO:0031424 9.73 DSC2 DSG2 KRT10 KRT14
3 cornification GO:0070268 9.71 DSC2 DSG2 KRT10 KRT14
4 positive regulation of catalytic activity GO:0043085 9.7 NCSTN PSEN1 PSENEN
5 regulation of inflammatory response GO:0050727 9.69 DROSHA NOD2 TNF
6 positive regulation of MAP kinase activity GO:0043406 9.65 NOD2 PSEN1 TNF
7 protein processing GO:0016485 9.63 NCSTN PSEN1 PSENEN
8 regulation of heart rate by cardiac conduction GO:0086091 9.61 DSC2 DSG2
9 positive regulation of interleukin-8 production GO:0032757 9.61 NOD2 TNF
10 regulation of synaptic transmission, glutamatergic GO:0051966 9.6 PSEN1 TNF
11 positive regulation of osteoclast differentiation GO:0045672 9.59 IL17A TNF
12 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 IL17A NOD2
13 amyloid-beta metabolic process GO:0050435 9.57 NCSTN PSEN1
14 epithelial cell proliferation GO:0050673 9.56 NCSTN PSEN1
15 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.55 DSC2 DSG2
16 astrocyte activation GO:0048143 9.54 PSEN1 TNF
17 membrane protein ectodomain proteolysis GO:0006509 9.54 NCSTN PSEN1 PSENEN
18 amyloid precursor protein metabolic process GO:0042982 9.5 NCSTN PSEN1 PSENEN
19 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.49 DSC2 DSG2
20 Notch receptor processing GO:0007220 9.43 NCSTN PSEN1 PSENEN
21 amyloid precursor protein catabolic process GO:0042987 9.33 NCSTN PSEN1 PSENEN
22 Notch receptor processing, ligand-dependent GO:0035333 9.13 NCSTN PSEN1 PSENEN
23 amyloid-beta formation GO:0034205 8.8 NCSTN PSEN1 PSENEN

Molecular functions related to Hidradenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.62 DSC2 DSG2

Sources for Hidradenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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