Hidradenitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HDR003 MIFTS: 52	Hidradenitis Categories: Endocrine diseases, Skin diseases
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Aliases & Classifications for Hidradenitis

MalaCards integrated aliases for Hidradenitis:

Name: Hidradenitis ¹² ⁴⁵ ¹⁵ ⁷⁴

Hydradenitis ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2282

ICD9CM ³⁶ 705.83

MeSH ⁴⁵ D016575

NCIt ⁵¹ C112190

SNOMED-CT ⁶⁹ 69741000

UMLS ⁷⁴ C0085160

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Summaries for Hidradenitis

Disease Ontology : ¹² A sweat gland disease that is characterized by inflammation of the apocrine sweat glands and has symptom erythema, edema, papules, plaques, pruritis, and pain.

MalaCards based summary : Hidradenitis, also known as hydradenitis, is related to hidradenitis suppurativa and pyoderma, and has symptoms including erythema An important gene associated with Hidradenitis is NCSTN (Nicastrin), and among its related pathways/superpathways are Developmental Biology and Th17 cell differentiation. The drugs Adalimumab and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and myeloid, and related phenotypes are growth/size/body region and digestive/alimentary

Wikipedia : ⁷⁷ Hidradenitis is any disease in which the histologic abnormality is primarily an inflammatory infiltrate... more...

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Related Diseases for Hidradenitis

Diseases related to Hidradenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)

#	Related Disease	Score	Top Affiliating Genes
1	hidradenitis suppurativa	31.3	DSC2 DSG2 IL12RB1 IL17A KRT10 KRT14
2	pyoderma	31.0	NOD2 TNF
3	pyoderma gangrenosum	31.0	NOD2 TNF
4	crohn's colitis	30.8	NOD2 TNF
5	inflammatory bowel disease	30.5	IL17A NOD2 TNF
6	joint disorders	30.2	IL17A TNF
7	colitis	30.2	IL17A NOD2 TNF
8	ulcerative colitis	30.2	IL17A NOD2 TNF
9	dowling-degos disease	30.1	DSC2 KRT14 NCSTN PSENEN
10	spondyloarthropathy 1	30.0	IL17A NOD2 TNF
11	spondylitis	30.0	IL17A NOD2 TNF
12	spondylarthropathy	30.0	NOD2 TNF
13	skin disease	29.8	IL17A KRT10 KRT14 TNF
14	melkersson-rosenthal syndrome	29.8	NOD2 TNF
15	sarcoidosis 1	29.6	IL12RB1 NOD2 TNF
16	pyoderma gangrenosum-acne-suppurative hidradenitis syndrome	12.3
17	acne inversa, familial, 1	11.7
18	perifolliculitis capitis abscedens et suffodiens, familial	11.4
19	acne inversa, familial, 2, with or without dowling-degos disease	11.4
20	papillon-lefevre syndrome	11.1
21	pyogenic sterile arthritis, pyoderma gangrenosum, and acne	11.1
22	acne inversa, familial, 3	11.1
23	neurofibromatosis, type ii	10.7
24	squamous cell carcinoma	10.6
25	crohn's disease	10.5
26	psoriasis	10.4
27	sebaceous gland disease	10.4	NCSTN PSENEN
28	miller fisher syndrome	10.3	PSENEN TNF
29	ocular toxoplasmosis	10.3	IL17A NOD2
30	ileocolitis	10.3	NOD2 TNF
31	granulomatous dermatitis	10.3	NOD2 TNF
32	trichosporonosis	10.3	IL17A TNF
33	inflammatory bowel disease 3	10.3	NOD2 TNF
34	streptococcal meningitis	10.3	NOD2 TNF
35	central nervous system vasculitis	10.3	IL17A TNF
36	orofacial granulomatosis	10.3	NOD2 TNF
37	arthritis	10.3
38	autoimmune disease of eyes, ear, nose and throat	10.3	IL17A TNF
39	sweat gland disease	10.2	KRT14 NCSTN
40	transverse myelitis	10.2	IL17A TNF
41	myelitis	10.2	IL17A TNF
42	anal canal squamous cell carcinoma	10.2	NCSTN PSEN1 PSENEN
43	primary systemic mycosis	10.2	IL17A TNF
44	dowling-degos disease 1	10.2
45	malignant atrophic papulosis	10.2
46	mycoplasma pneumoniae pneumonia	10.2	IL17A TNF
47	blau syndrome	10.2	NOD2 TNF
48	filamentary keratitis	10.2	IL17A KRT10
49	stromal keratitis	10.2	IL17A TNF
50	pustulosis of palm and sole	10.2

Graphical network of the top 20 diseases related to Hidradenitis:

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Symptoms & Phenotypes for Hidradenitis

Symptoms:

¹²

• erythema

MGI Mouse Phenotypes related to Hidradenitis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.86	DROSHA IL12RB1 IL17A KRT14 NCSTN NOD2
2	digestive/alimentary	MP:0005381	9.8	DROSHA IL17A KRT14 NOD2 PSEN1 TNF
3	craniofacial	MP:0005382	9.77	IL17A KRT14 NCSTN PSEN1 TNF
4	hematopoietic system	MP:0005397	9.76	DROSHA IL12RB1 IL17A KRT14 NCSTN NOD2
5	immune system	MP:0005387	9.56	DROSHA IL12RB1 IL17A KRT14 NCSTN NOD2
6	mortality/aging	MP:0010768	9.28	DROSHA DSG2 IL17A KRT14 NCSTN NOD2

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Drugs & Therapeutics for Hidradenitis

Drugs for Hidradenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Adalimumab

Approved

Phase 4,Phase 3,Phase 2

331731-18-1

16219006

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Anesthetics

Phase 4,Phase 1

Antirheumatic Agents

Phase 4,Phase 3,Phase 2,Phase 1

Immunologic Factors

Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Bacterial Agents

Phase 3,Phase 2,Not Applicable

Antibiotics, Antitubercular

Phase 3,Not Applicable

Antibodies

Phase 3,Phase 2,Phase 1,Early Phase 1

Immunoglobulins

Phase 3,Phase 2,Phase 1,Early Phase 1

Antibodies, Monoclonal

Phase 3,Phase 2,Phase 1,Early Phase 1

Apremilast

Approved, Investigational

Phase 2

608141-41-9

11561674

Infliximab

Approved

Phase 2

170277-31-3

Etanercept

Approved, Investigational

Phase 2

185243-69-0

Ustekinumab

Approved, Investigational

Phase 2

815610-63-0

Hydroxychloroquine

Approved

Phase 1, Phase 2

118-42-3

3652

Brodalumab

Approved, Investigational

Phase 2

1174395-19-7

Polyestradiol phosphate

Approved

Phase 2

28014-46-2

Estradiol

Approved, Investigational, Vet_approved

Phase 2

50-28-2

5757

Ethinyl Estradiol

Approved

Phase 2

57-63-6

5991

Drospirenone

Approved

Phase 2

67392-87-4

68873

Glutamic Acid

Approved, Nutraceutical

Phase 2

56-86-0

33032

Proline

Approved, Nutraceutical

Phase 2

147-85-3

145742

Anti-Infective Agents

Phase 2,Phase 1,Not Applicable

Immunosuppressive Agents

Phase 2,Not Applicable

Dermatologic Agents

Phase 2,Not Applicable

Pharmaceutical Solutions

Phase 2,Phase 1,Not Applicable

Hormones

Phase 2,Not Applicable

Hormone Antagonists

Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2,Not Applicable

Analgesics

Phase 2

Analgesics, Non-Narcotic

Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 2

Angiogenesis Inhibitors

Phase 2

Angiogenesis Modulating Agents

Phase 2

Peripheral Nervous System Agents

Phase 2,Not Applicable

Interleukin 1 Receptor Antagonist Protein

Phase 2

Gastrointestinal Agents

Phase 2

Complement System Proteins

Phase 2

lysine

Phase 2

Antimalarials

Phase 1, Phase 2

Antiprotozoal Agents

Phase 1, Phase 2

Antiparasitic Agents

Phase 1, Phase 2

Epidiolex

Phase 2

Olive

Phase 2

chlorophyllin

Phase 2

Contraceptives, Oral

Phase 2

Mineralocorticoid Receptor Antagonists

Phase 2

Contraceptive Agents

Phase 2

Natriuretic Agents

Phase 2

Drospirenone and ethinyl estradiol combination

Phase 2

Interventional clinical trials:

(show top 50) (show all 77)

#	Name	Status	NCT ID	Phase	Drugs
1	Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS	Recruiting	NCT03221621	Phase 4	Adalimumab Injection
2	Safety and Efficacy of Humira (Adalimumab) for Hidradenitis Suppurativa (HS) Peri-Surgically (SHARPS Study)	Active, not recruiting	NCT02808975	Phase 4	Adalimumab;Placebo
3	Efficacy and Safety Study of Adalimumab in Treatment of Hidradenitis Suppurativa	Completed	NCT01468207	Phase 3
4	Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa	Completed	NCT01468233	Phase 3
5	Open-label Study of the Safety and Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa	Completed	NCT01635764	Phase 3
6	Study of Efficacy and Safety of Two Secukinumab Dose Regimens in Subjects With Moderate to Severe Hidradenitis Suppurativa (HS)	Recruiting	NCT03713632	Phase 3	Secukinumab
7	This is a Study of Efficacy and Safety of Two Secukinumab Dose Regimens in Subjects With Moderate to Severe Hidradenitis Suppurativa (HS).	Recruiting	NCT03713619	Phase 3	secukinumab
8	Effect of Sclerotherapy on Fistulas and Sinus Tracts in Hidradenitis Suppurativa	Recruiting	NCT02805595	Phase 3	23.4% Hypertonic saline;Saline
9	Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa	Active, not recruiting	NCT02904902	Phase 3	adalimumab
10	To Determine the Efficacy of a Laser Device for the Treatment of Hidradenitis Suppurativa	Terminated	NCT00367328	Phase 3
11	A Study to Test the Efficacy, Safety and Pharmacokinetics of Bimekizumab in Subjects With Moderate to Severe Hidradenitis Suppurativa.	Completed	NCT03248531	Phase 2	Bimekizumab;Adalimumab
12	Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients	Completed	NCT02421172	Phase 2	Placebo
13	Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa	Completed	NCT02695212	Phase 2	Apremilast
14	To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa	Completed	NCT00827996	Phase 2	adalimumab
15	Anakinra as a Treatment for Hydradenitis Suppurativa	Completed	NCT01516749	Phase 2	anakinra
16	Study to Assess the Safety and Efficacy of Infliximab to Treat Hidradenitis Suppurtativa	Completed	NCT00795574	Phase 2	infliximab;Placebo Comparator
17	Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa	Completed	NCT03001622	Phase 2
18	Etanercept in Hidradenitis Suppurativa	Completed	NCT00329823	Phase 2	Etanercept sc 50mg per week for 12 weeks
19	Etanercept for Treatment of Hidradenitis	Completed	NCT00107991	Phase 2	etanercept
20	Anakinra in Hidradenitis Suppurativa	Completed	NCT01558375	Phase 2	Water for injection;Anakinra
21	MABp1 IN HIDRADENITIS SUPPURATIVA REFRACTORY TO ADALIMUMAB	Completed	NCT02643654	Phase 2	MABp1;Placebo
22	A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa	Completed	NCT01704534	Phase 2	Ustekinumab
23	Short-term Safety, Efficacy and Mode of Action of Apremilast in Moderate Suppurative Hidradenitis	Completed	NCT03049267	Phase 2	Apremilast;Placebo Oral Tablet
24	Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa	Completed	NCT00918255	Phase 2	Placebo
25	Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa	Recruiting	NCT03827798	Phase 2	CFZ533;Placebo to CFZ533;LYS006;Placebo to LYS006
26	A Study of Bermekimab in Patients With Hidradenitis Suppurativa	Recruiting	NCT03512275	Phase 2	Bermekimab Monoclonal Antibody 400 mg
27	Evaluation of Safety and Efficacy of Avacopan in Subjects With Moderate to Severe Hidradenitis Suppurativa	Recruiting	NCT03852472	Phase 2	Avacopan
28	A Study to Evaluate the Efficacy, Safety, and Tolerability of Guselkumab for the Treatment of Participants With Moderate to Severe Hidradenitis Suppurativa (HS)	Recruiting	NCT03628924	Phase 2	Guselkumab dose 1;Guselkumab dose 2;Guselkumab dose 3;Placebo
29	A Placebo-Controlled Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa	Recruiting	NCT03607487	Phase 2	INCB054707;Placebo
30	Efficacy and Safety Study of IFX-1 in Patients With Moderate to Severe Hidradenitis Suppurativa (HS)	Active, not recruiting	NCT03487276	Phase 2	IFX-1;Placebo
31	A Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa	Active, not recruiting	NCT03569371	Phase 2	INCB054707
32	Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa	Active, not recruiting	NCT03275870	Phase 1, Phase 2	Hydroxychloroquine
33	A Global Study Comparing Risankizumab to Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa	Not yet recruiting	NCT03926169	Phase 2	Risankizumab;Placebo for risankizumab
34	Treatment of Moderate Hidradenitis Suppurativa	Not yet recruiting	NCT03910803	Phase 2	Brodalumab
35	Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa	Not yet recruiting	NCT03929835	Phase 2	Cannabis oil;Placebo
36	Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa	Terminated	NCT01838499	Phase 2
37	A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS	Terminated	NCT00722800	Phase 2	drospirenone and ethinyl estradiol (YAZ);Placebo
38	Efficacy and Safety of Efalizumab in the Treatment of Moderate-Severe Hydradenitis Suppurativa	Completed	NCT00134134	Phase 1	efalizumab
39	Endoscopic Pilonidal Sinus Treatment With Additional Crystalized Phenol	Completed	NCT02277340	Phase 1
40	Patients With Hidradenitis vs Patients With Psoriasis: Psychological Impact	Unknown status	NCT02999698
41	An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa.	Unknown status	NCT01818167	Not Applicable	10% Benzoyl Peroxide Topical Body Wash;Provodine Topical Cream
42	Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing	Unknown status	NCT02163746	Not Applicable
43	Group Psychotherapy for Patients With Hidradenitis Suppurativa: Effects in Quality of Life	Unknown status	NCT02904408	Not Applicable
44	Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa	Unknown status	NCT01063270	Not Applicable	Clindamycin & Rifampin
45	Efficacy of Percutaneous Injection of Triamcinolone in the Treatment of Mammillary Fistula	Unknown status	NCT01315080
46	Effectiveness of Adalimumab in Moderate to Severe HidrAdenitis SuppuRativa Patients - a Multi cOuNtry studY in Real Life Setting	Completed	NCT02786576
47	Association Between Hidradenitis Suppurativa and Spondyloarthritis	Completed	NCT03668925	Not Applicable
48	A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.	Completed	NCT02781818	Not Applicable	Triamcinolone Acetonide 10mg/mL;Triamcinolone Acetonide 40mg/mL;Normal Saline
49	Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa	Completed	NCT00494351	Not Applicable
50	Pilot Study on Botulinum Toxin B as Treatment for Hidradenitis Suppurativa	Completed	NCT03103074	Not Applicable	Botulinum B Toxin

Search NIH Clinical Center for Hidradenitis

Cochrane evidence based reviews: hidradenitis

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Genetic Tests for Hidradenitis

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Anatomical Context for Hidradenitis

MalaCards organs/tissues related to Hidradenitis:

⁴²

Neutrophil, Skin, Myeloid, Thyroid, Testes, Breast, Lung

Sources

Publications for Hidradenitis

Articles related to Hidradenitis:

(show top 50) (show all 1818)

#	Title	Authors	Year
1	To what extent do disease severity and illness perceptions explain depression, anxiety and quality of life in hidradenitis suppurativa? ( 30171696 )	Pavon Blanco A...Weinman J	2019
2	Depression in Hidradenitis Suppurativa. ( 31099413 )	Senthilnathan A...Pichardo RO	2019
3	The associations of depression and coping methods on health-related quality of life for those with hidradenitis suppurativa. ( 30876533 )	Butt M...Kirby JS	2019
4	Hidradenitis suppurativa and diabetes mellitus: updated systematic review and adjusted meta-analysis. ( 30730068 )	Phan K...Smith SD	2019
5	Prevalence and Description of Hidradenitis Suppurativa in Down Syndrome: A Cross-sectional Study of 783 Subjects. ( 30460373 )	Poizeau F...Hotz C	2019
6	Non-Pharmacologic Approaches for Hidradenitis Suppurativa - A Systematic Review. ( 31106609 )	Hendricks AJ...Shi VY	2019
7	E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions. ( 31107992 )	Nelson AM...Danby FW	2019
8	Hidradenitis Suppurativa and Botulinum Toxin Type a Therapy: Two Cases. ( 30693648 )	Campanati A...Offidani A	2019
9	Association Between Hidradenitis Suppurativa and Lymphoma. ( 30698627 )	Tannenbaum R...Garg A	2019
10	Biologics for hidradenitis suppurativa: an update. ( 30702012 )	W?odarek K...Szepietowski JC	2019
11	Could isotretinoin flare hidradenitis suppurativa? A case series. ( 30719727 )	Gallagher CG...Tobin AMT	2019
12	Abstracts of the 8th European Hidradenitis Suppurativa Foundation (EHSF) Conference, 6-8 February 2019, Wrocław, Poland. ( 30723943 )		2019
13	Interrater agreement and reliability of outcome measurement instruments and staging systems used in hidradenitis suppurativa. ( 30724351 )	Thorlacius L...Jemec GBE	2019
14	Preoperative Ultrasound for Evaluation of Hidradenitis Suppurativa. ( 30726198 )	Lyons AB...Hamzavi IH	2019
15	Overall and subgroup prevalence of pyoderma gangrenosum among patients with hidradenitis suppurativa: A population-based analysis in the United States. ( 30738122 )	Tannenbaum R...Garg A	2019
16	Secukinumab and hidradenitis suppurativa: Friends or foes? ( 30740502 )	Marasca C...Fabbrocini G	2019
17	Understanding the long diagnostic delay for hidradenitis suppurativa: a national survey among French general practitioners. ( 30761989 )	Clerc H...Maruani A	2019
18	Korean gender differences in hidradenitis suppuratva: nature or nurture? ( 30767281 )	Happle R	2019
19	Response to "Korean gender differences in hidradenitis suppurativa: nature or nurture?" ( 30767325 )	Lee JH...Bae JM	2019
20	Hidradenitis Suppurativa as a Systemic Disease: Association With Metabolic Syndrome. ( 30797524 )	Martorell A	2019
21	Exophytic Mass Arising Within Hidradenitis Suppurativa: Answer. ( 30801344 )	Beard CJ...Bandino JP	2019
22	Open-label, Investigator-Initiated, Single Site Exploratory Trial Evaluating Secukinumab, an anti IL17A monoclonal antibody, for Patients with Moderate-to-Severe Hidradenitis Suppurativa. ( 30801662 )	Prussick L...Rosmarin D	2019
23	Virulent Staphylococcus lugdunensis with limited genetic diversity in hidradenitis suppurativa lesions. ( 30801776 )	Ardon CB...Jenssen H	2019
24	Exophytic Mass Arising Within Hidradenitis Suppurativa: Challenge. ( 30802225 )	Beard CJ...Bandino JP	2019
25	Isotretinoin and Hidradenitis Suppurativa. ( 30802991 )	J?rgensen AR...Ring HC	2019
26	Hidradenitis Suppurativa and Diabetes: Big Data Bias Masks a True Association. ( 30802992 )	Frew JW	2019
27	Combination hyperbaric oxygen therapy and ustekinumab for severe hidradenitis suppurativa. ( 30805965 )	Provini LE...Jen M	2019
28	Apremilast for the Treatment of Mild-to-Moderate Hidradenitis Suppurativa in a Prospective, Open-Label, Phase 2 Study ( 30811140 )	Kerdel FR...Kerdel FA	2019
29	Effectiveness, safety and tolerability of drainage and punch-trocar-assisted cryoinsufflation (cryopunch) in the treatment of inflammatory acute fluid collections in hidradenitis suppurativa patients. ( 30811686 )	Molina-Leyva A...Cuenca-Barrales C	2019
30	Reply to: "Could Isotretinoin flare Hidradentis suppurativa? A Case Series". ( 30816560 )	Caposiena Caro RD...Bianchi L	2019
31	Two-step surgery in extensive anogenital hidradenitis: What kind of faecal management? ( 30821118 )	Garbarino F...Magnoni C	2019
32	Squamous carcinoma over perineal hidradenitis suppurativa. ( 30825999 )	Cerd?n Santacruz C...Cerd?n Miguel J	2019
33	Transcriptome patterns in hidradenitis suppurativa: support for the role of antimicrobial peptides and interferon pathways in disease pathogenesis. ( 30828847 )	Shanmugam VK...Crandall KA	2019
34	A new Th-17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26. ( 30829398 )	Scala E...Balato A	2019
35	Hidradenitis Suppurativa (Hurley I/II): Serial Excisions with Primary Wound Closure Under Local Anesthesia As Most Adequate Treatment Approach. ( 30834010 )	Tchernev G...Temelkova I	2019
36	Association Between Hidradenitis Suppurativa and Metabolic Syndrome. ( 30846164 )	Rodr?guez-Zu?iga MJM...Ortega-Loayza AG	2019
37	Topical, systemic and biologic therapies in hidradenitis suppurativa: pathogenic insights by examining therapeutic mechanisms. ( 30854183 )	Frew JW...Krueger JG	2019
38	Commentary: Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model. ( 30858850 )	Frew JW	2019
39	North American Clinical Management Guidelines for Hidradenitis Suppurativa: a Publication from the United States and Canadian Hidradenitis Suppurativa Foundations. Part II: Topical, Intralesional, and Systemic medical Management. ( 30872149 )	Alikhan A...Poulin Y	2019
40	Comment on "Interruption of oral clindamycin plus rifampicin therapy in patients with hidradenitis suppurativa: an observational study to assess prevalence and causes". ( 30872151 )	Marasca C...Fabbrocini G	2019
41	Reply to "Comment on 'Interruption of oral clindamycin plus rifampicin therapy in patients with hidradenitis suppurativa: an observational study to assess prevalence and causes' ". ( 30872153 )	Schneller-Pavelescu L...Pascual JC	2019
42	North American Clinical Management Guidelines for Hidradenitis Suppurativa: a Publication from the United States and Canadian Hidradenitis Suppurativa Foundations. Part I: Diagnosis, Evaluation, and the use of Complementary and Procedural Management. ( 30872156 )	Alikhan A...Poulin Y	2019
43	Lack of photographic documentation undermines assessment of hidradenitis suppurativa phenotypes. ( 30874297 )	van Straalen KR...van der Zee HH	2019
44	Assessing the Efficacy of New Biologic Therapies in Hidradenitis Suppurativa Consistency vs Bias in Outcome Measures in Moderate and Severe Disease. ( 30875132 )	Frew JW	2019
45	Reply to comment: guselkumab in the treatment of severe hidradenitis suppurativa. ( 30875137 )	Kovacs M...Podda M	2019
46	Mast cells in hidradenitis suppurativa: a clinicopathological study. ( 30877368 )	List EK...Jemec GBE	2019
47	Treatment of Hidradenitis Suppurativa with Extensive Resection of the Lesion and Coverage with Perforator Flaps of the Lateral Thoracic Wall (Lateral Thoracic Artery, Thoracodorsal Artery Perforators). ( 30881834 )	Rodriguez JM...Naranjo K	2019
48	Hidradenitis Suppurativa: Estimated Prevalence, Clinical Features, Concomitant Conditions, and Diagnostic Delay in a University Teaching Hospital in Buenos Aires, Argentina. ( 30885385 )	Zimman S...Mazzuoccolo LD	2019
49	Commentary on Squamous Cell Carcinoma in Perineal, Perianal, and Gluteal Hidradenitis Suppurativa: Experience in 12 Patients. ( 30893153 )	Bennett RG	2019
50	Defining Fistular Patterns in Hidradenitis Suppurativa: Impact in the Management. ( 30893168 )	Martorell A...Sanz-Motilva V	2019

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Genes for Hidradenitis

Genes related to Hidradenitis (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NCSTN	Nicastrin	Protein Coding	25.31	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	23.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	IL17A	Interleukin 17A	Protein Coding	22.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TNF	Tumor Necrosis Factor	Protein Coding	22.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	PSEN1	Presenilin 1	Protein Coding	21.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	20.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	KRT14	Keratin 14	Protein Coding	20.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	KRT10	Keratin 10	Protein Coding	20.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	19.79	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	DSC2	Desmocollin 2	Protein Coding	19.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	DSG2	Desmoglein 2	Protein Coding	19.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	DROSHA	Drosha Ribonuclease III	Protein Coding	19.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Hidradenitis

Sources

Expression for Hidradenitis

Search GEO for disease gene expression data for Hidradenitis.

Sources

Pathways for Hidradenitis

Pathways related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁷ Show member pathways Axon guidance ⁶⁷	13.08	DSC2 DSG2 KRT10 KRT14 NCSTN PSENEN
2	Th17 cell differentiation ³⁸ Show member pathways IL-22 Pathway ⁶⁵ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease (IBD) ³⁸ Th1 and Th2 cell differentiation ³⁸	12.32	IL12RB1 IL17A NOD2 TNF
3	Keratinization ⁶⁷ Show member pathways Formation of the cornified envelope ⁶⁷	12.21	DSC2 DSG2 KRT10 KRT14
4	Wnt / Hedgehog / Notch ⁴	11.98	NCSTN PSEN1 PSENEN
5	Development NOTCH1-mediated pathway for NF-KB activity modulation ²³ Show member pathways Development Notch Signaling Pathway ²³ Transcription Sin3 and NuRD in transcription regulation ²³	11.94	NCSTN PSEN1 PSENEN
6	Presenilin-Mediated Signaling ⁶⁵	11.84	NCSTN PSEN1 PSENEN
7	Th1 Differentiation Pathway ⁶⁶ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁶	11.78	IL12RB1 IL17A TNF
8	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.51	IL12RB1 IL17A TNF
9	p75(NTR)-mediated signaling ¹ Show member pathways Ceramide signalling ⁶⁷ NFG and proNGF binds to p75NTR ⁶⁷	11.4	NCSTN PSEN1 PSENEN
10	A-beta Signaling Pathways ⁶⁶	11.17	NCSTN PSEN1 PSENEN
11	Development and heterogeneity of the ILC family ¹	11.06	IL17A TNF
12	Presenilin action in Notch and Wnt signaling ¹	10.99	NCSTN PSEN1 PSENEN
13	Canonical NF-kappaB pathway ¹	10.89	NOD2 TNF
14	A-beta Pathways: Plaque Formation and APP Metabolism ⁶⁶	10.49	NCSTN PSEN1 PSENEN
15	Notch Pathway ⁷³	10.07	PSEN1 PSENEN
16	Syndecan-3-mediated signaling events ¹	10.03	NCSTN PSEN1 PSENEN

Sources

GO Terms for Hidradenitis

Cellular components related to Hidradenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.56	DSG2 NOD2 PSEN1 TNF
2	desmosome	GO:0030057	9.16	DSC2 DSG2
3	cornified envelope	GO:0001533	9.13	DSC2 DSG2 KRT10
4	gamma-secretase complex	GO:0070765	8.8	NCSTN PSEN1 PSENEN

Biological processes related to Hidradenitis according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	Notch signaling pathway	GO:0007219	9.75	NCSTN PSEN1 PSENEN
2	keratinization	GO:0031424	9.73	DSC2 DSG2 KRT10 KRT14
3	cornification	GO:0070268	9.71	DSC2 DSG2 KRT10 KRT14
4	positive regulation of catalytic activity	GO:0043085	9.7	NCSTN PSEN1 PSENEN
5	regulation of inflammatory response	GO:0050727	9.69	DROSHA NOD2 TNF
6	positive regulation of MAP kinase activity	GO:0043406	9.65	NOD2 PSEN1 TNF
7	protein processing	GO:0016485	9.63	NCSTN PSEN1 PSENEN
8	regulation of heart rate by cardiac conduction	GO:0086091	9.61	DSC2 DSG2
9	positive regulation of interleukin-8 production	GO:0032757	9.61	NOD2 TNF
10	regulation of synaptic transmission, glutamatergic	GO:0051966	9.6	PSEN1 TNF
11	positive regulation of osteoclast differentiation	GO:0045672	9.59	IL17A TNF
12	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.58	IL17A NOD2
13	amyloid-beta metabolic process	GO:0050435	9.57	NCSTN PSEN1
14	epithelial cell proliferation	GO:0050673	9.56	NCSTN PSEN1
15	regulation of ventricular cardiac muscle cell action potential	GO:0098911	9.55	DSC2 DSG2
16	astrocyte activation	GO:0048143	9.54	PSEN1 TNF
17	membrane protein ectodomain proteolysis	GO:0006509	9.54	NCSTN PSEN1 PSENEN
18	amyloid precursor protein metabolic process	GO:0042982	9.5	NCSTN PSEN1 PSENEN
19	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	GO:0086073	9.49	DSC2 DSG2
20	Notch receptor processing	GO:0007220	9.43	NCSTN PSEN1 PSENEN
21	amyloid precursor protein catabolic process	GO:0042987	9.33	NCSTN PSEN1 PSENEN
22	Notch receptor processing, ligand-dependent	GO:0035333	9.13	NCSTN PSEN1 PSENEN
23	amyloid-beta formation	GO:0034205	8.8	NCSTN PSEN1 PSENEN

Molecular functions related to Hidradenitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	GO:0086083	8.62	DSC2 DSG2

Sources

Sources for Hidradenitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia