MCID: HDR006
MIFTS: 46

Hidradenocarcinoma

Categories: Rare diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Hidradenocarcinoma

MalaCards integrated aliases for Hidradenocarcinoma:

Name: Hidradenocarcinoma 53
Primary Mucoepidermoid Cutaneous Carcinoma 53
Malignant Nodular/clear Cell Hidradenoma 53
Malignant Clear Cell Acrospiroma 53
Clear Cell Eccrine Carcinoma 53
Sweat Gland Adenocarcinoma 73
Eccrine Ductal Carcinoma 73
Malignant Acrospiroma 53

Classifications:



External Ids:

UMLS 73 C0334344

Summaries for Hidradenocarcinoma

NIH Rare Diseases : 53 Hidradenocarcinoma is a rare tumor caused by the abnormal growth of cells in a sweat gland.  It is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but can be been found on other parts of the body. This type of tumor most often develops in people between the ages of 30-60 years old, but has been found in children.  Hidradenocarcinoma is usually painless and tends to grow slowly, but may spread into nearby tissues, especially lymph nodes, or to more distant parts of the body (metastasis). The cause of the tumor is unknown. Diagnosis is usually made by careful examination and a series of special skin tests. The main treatment is surgical removal of the tumor often followed by radiation therapy and/or chemotherapy. Long term outlook is best when the cancer is found early.

MalaCards based summary : Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to nodular hidradenoma and sweat gland cancer. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Related Diseases for Hidradenocarcinoma

Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 nodular hidradenoma 30.0 KRT7 PIP VIM
2 sweat gland cancer 29.4 ERBB2 ESR1 KRT5 KRT7 TP53
3 vulvar clear cell hidradenocarcinoma 12.0
4 breast neuroendocrine neoplasm 11.0 ERBB2 PIP
5 gallbladder squamous cell carcinoma 10.9 ERBB2 TP53
6 gastric papillary adenocarcinoma 10.9 ERBB2 TP53
7 malignant acrospiroma 10.9
8 eccrine porocarcinoma 10.9
9 bartholin's duct cyst 10.9 PIP TP53
10 uterine corpus serous adenocarcinoma 10.9 ERBB2 TP53
11 cystic basal cell carcinoma 10.8 KRT7 TP63
12 solid adenocarcinoma with mucin production 10.8 KRT7 NKX2-1
13 glassy cell carcinoma of the cervix 10.8 ERBB2 ESR1
14 breast cystic hypersecretory carcinoma 10.8 ERBB2 KRT5
15 breast metaplastic carcinoma 10.8 ERBB2 KRT5
16 breast intraductal proliferative lesion 10.8 EGFR ERBB2
17 vestibular gland benign neoplasm 10.8 ESR1 TP53
18 endometrial clear cell adenocarcinoma 10.7 ESR1 TP53
19 bartholin's gland adenoma 10.7 ESR1 TP53
20 hemangioma of lung 10.7 NKX2-1 TP63
21 large intestine adenocarcinoma 10.7 KRT7 PIP
22 ovarian germ cell teratoma 10.7 KRT7 NKX2-1
23 malignant giant cell tumor 10.7 S100B TP53
24 ovarian serous cystadenocarcinoma 10.7 BCL2 ERBB2 TP53
25 vulval paget's disease 10.7 ERBB2 KRT7 PIP
26 breast medullary carcinoma 10.7 ERBB2 ESR1
27 comedo carcinoma 10.7 ERBB2 ESR1
28 paget disease, extramammary 10.7 ERBB2 KRT7 PIP
29 inverted transitional papilloma 10.7 KRT5 KRT7
30 vulvar intraepithelial neoplasia 10.7 KRT5 TP53
31 intracystic papillary adenoma 10.7 EGFR ERBB2
32 lung acinar adenocarcinoma 10.6 KRT7 NKX2-1
33 progesterone-receptor negative breast cancer 10.6 EGFR ERBB2
34 small cell carcinoma of the bladder 10.6 KRT7 NKX2-1
35 breast mucoepidermoid carcinoma 10.6 ERBB2 MUC5AC
36 balloon cell malignant melanoma 10.6 KRT5 KRT7
37 papillary thyroid microcarcinoma 10.6 MKI67 NKX2-1 TP63
38 female reproductive endometrioid cancer 10.6 KRT7 TP53
39 ovarian germ cell cancer 10.6 KRT7 NKX2-1
40 ovary adenocarcinoma 10.6 ERBB2 KRT7 TP53
41 cervical squamous cell carcinoma 10.6 MKI67 TP53 TP63
42 chordoid glioma 10.6 NKX2-1 S100B TP53
43 ovarian cancer 1 10.6 ERBB2 KRT7 TP53
44 sensory organ benign neoplasm 10.6 KRT5 KRT7
45 papillary serous adenocarcinoma 10.6 KRT7 NKX2-1 TP53
46 keratinizing squamous cell carcinoma 10.6 KRT5 TP53
47 integumentary system cancer 10.6 KRT7 PIP TP53
48 uterine corpus cancer 10.6 ERBB2 ESR1 TP53
49 breast papillomatosis 10.5 CCND1 ERBB2
50 renal cell carcinoma, papillary, 1 10.5 ERBB2 KRT7 TP53

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to Hidradenocarcinoma

Symptoms & Phenotypes for Hidradenocarcinoma

GenomeRNAi Phenotypes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 33)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.92 S100B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.92 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.92 BCL2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.92 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.92 BCL2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.92 EGFR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.92 BCL2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.92 VIM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.92 BCL2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.92 ERBB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.92 ERBB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.92 ERBB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.92 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.92 BCL2 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.92 VIM
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.92 VIM EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.92 BCL2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.92 BCL2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.92 ERBB2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.92 EGFR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.92 BCL2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.92 EGFR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.92 VIM
24 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.92 VIM
25 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.92 ERBB2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.92 BCL2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.92 EGFR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.92 S100B VIM ERBB2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.92 BCL2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.92 S100B BCL2 VIM EGFR ERBB2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.92 BCL2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.92 BCL2
33 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 ESR1 MKI67 PIP CCND1

MGI Mouse Phenotypes related to Hidradenocarcinoma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.39 CCND1 EGFR BCL2 CDX2 KRT7 ESR1
2 digestive/alimentary MP:0005381 10.37 CCND1 EGFR BCL2 CDX2 KRT5 ESR1
3 cardiovascular system MP:0005385 10.36 CCND1 EGFR BCL2 CDX2 ESR1 ERBB2
4 homeostasis/metabolism MP:0005376 10.36 CCND1 EGFR BCL2 CDX2 KRT7 ESR1
5 behavior/neurological MP:0005386 10.33 CCND1 BCL2 ERBB2 KRT5 ESR1 TP53
6 endocrine/exocrine gland MP:0005379 10.28 CCND1 EGFR BCL2 CDX2 ESR1 ERBB2
7 growth/size/body region MP:0005378 10.26 CCND1 BCL2 CDX2 KRT5 ERBB2 EGFR
8 mortality/aging MP:0010768 10.21 CCND1 BCL2 CDX2 ERBB2 KRT5 EGFR
9 immune system MP:0005387 10.19 CCND1 BCL2 EGFR ESR1 TP53 PIP
10 embryo MP:0005380 10.15 BCL2 CDX2 ERBB2 EGFR ESR1 TP53
11 integument MP:0010771 10.13 CCND1 EGFR BCL2 KRT5 ESR1 ERBB2
12 craniofacial MP:0005382 10.11 CCND1 EGFR BCL2 ERBB2 KRT5 TP53
13 neoplasm MP:0002006 10.07 CCND1 EGFR BCL2 CDX2 ESR1 ERBB2
14 limbs/digits/tail MP:0005371 10 EGFR CDX2 ERBB2 KRT5 ESR1 TP53
15 normal MP:0002873 9.96 CCND1 EGFR CDX2 MKI67 ESR1 ERBB2
16 muscle MP:0005369 9.95 BCL2 ERBB2 EGFR ESR1 TP53 TP63
17 reproductive system MP:0005389 9.9 CCND1 EGFR BCL2 CDX2 ESR1 ERBB2
18 no phenotypic analysis MP:0003012 9.87 KRT5 MKI67 EGFR ESR1 TP53 NKX2-1
19 respiratory system MP:0005388 9.56 CCND1 EGFR ERBB2 ESR1 TP53 NKX2-1
20 skeleton MP:0005390 9.23 CCND1 CDX2 ERBB2 EGFR ESR1 NKX2-1

Drugs & Therapeutics for Hidradenocarcinoma

Drugs for Hidradenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies Phase 2
3 Immunoglobulins Phase 2
4 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

Anatomical Context for Hidradenocarcinoma

MalaCards organs/tissues related to Hidradenocarcinoma:

41
Skin, Lymph Node, Testes, Breast

Publications for Hidradenocarcinoma

Articles related to Hidradenocarcinoma:

(show top 50) (show all 61)
# Title Authors Year
1
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. ( 29166328 )
2018
2
Malignant Hidradenocarcinoma in the Lower Extremity: A Case Report of a Rare Tumor. ( 29472169 )
2018
3
Hidradenocarcinoma of the Dorsum of the Hand. ( 28685735 )
2017
4
Translocation of the MAML2 gene in hidradenocarcinoma. ( 28295544 )
2017
5
Complete response in a patient with gynecological hidradenocarcinoma treated with exclusive external beam radiotherapy and brachytherapy: a case report. ( 29441103 )
2017
6
Perianal eccrine hidradenocarcinoma in the context of a fistulising Crohn's disease. ( 28827020 )
2017
7
Fatal hidradenocarcinoma of the scalp: A case report. ( 28410954 )
2017
8
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis. ( 26876052 )
2016
9
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. ( 26500736 )
2015
10
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. ( 25815059 )
2015
11
Case report: clear cell hidradenocarcinoma of the nail bed. ( 26416223 )
2015
12
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. ( 25918615 )
2015
13
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. ( 26288440 )
2015
14
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. ( 26319286 )
2015
15
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. ( 25627632 )
2015
16
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. ( 25513929 )
2014
17
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. ( 25006935 )
2014
18
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. ( 24490986 )
2014
19
Hidradenocarcinoma of the chest. ( 25382529 )
2014
20
Hidradenocarcinoma of the Finger. ( 23486133 )
2013
21
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. ( 23053773 )
2013
22
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. ( 22998159 )
2013
23
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. ( 23489214 )
2013
24
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. ( 23466792 )
2013
25
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. ( 22678002 )
2012
26
No sweat, a rare case of hidradenocarcinoma. ( 22369809 )
2012
27
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. ( 23271300 )
2012
28
Hidradenocarcinoma of the fingertip: a case report and literature review. ( 21489038 )
2011
29
Radiotherapy on hidradenocarcinoma. ( 22540063 )
2011
30
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. ( 21892057 )
2011
31
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. ( 21844475 )
2011
32
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. ( 21044227 )
2010
33
Perianal nodular hidradenocarcinoma. Case report. ( 20478121 )
2010
34
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. ( 20572504 )
2010
35
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. ( 19522717 )
2010
36
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. ( 19476529 )
2009
37
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. ( 19215270 )
2009
38
Metastatic hidradenocarcinoma: Surgery and chemotherapy. ( 22666726 )
2009
39
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. ( 20596988 )
2009
40
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. ( 19384064 )
2009
41
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. ( 20740144 )
2009
42
Clear cell hidradenocarcinoma developing in pacemaker pocket. ( 18950311 )
2008
43
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. ( 17214855 )
2007
44
[Study of the ploidy and cellular cycle of hidradenomas and hidradenocarcinomas: a series of 13 cases]. ( 17657929 )
2007
45
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. ( 17103407 )
2007
46
Metastatic hidradenocarcinoma: efficacy of capecitabine. ( 17043204 )
2006
47
Hidradenocarcinoma: a histological and immunohistochemical study. ( 17083691 )
2006
48
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. ( 15355375 )
2004
49
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. ( 10955691 )
2000
50
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. ( 9788267 )
1998

Variations for Hidradenocarcinoma

Cosmic variations for Hidradenocarcinoma:

9
(show top 50) (show all 82)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10662 TP53 skin,neck,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 6
2 COSM607136 TGFBR1 skin,neck,carcinoma,NS c.1247C>T p.S416F 9:99146601-99146601 6
3 COSM6962965 SMO skin,neck,carcinoma,NS c.1103C>T p.P368L 7:129206332-129206332 6
4 COSM6962990 RARA skin,neck,carcinoma,NS c.1384C>T p.P462S 17:40356221-40356221 6
5 COSM6962984 RAD52 skin,neck,carcinoma,NS c.439G>A p.V147M 12:927173-927173 6
6 COSM6962994 PTPRT skin,neck,carcinoma,NS c.1607C>T p.S536L 20:42352239-42352239 6
7 COSM6962992 PTPRT skin,neck,carcinoma,NS c.1619G>A p.G540E 20:42352227-42352227 6
8 COSM6962970 PTPRD skin,neck,carcinoma,NS c.1736G>A p.S579N 9:8504347-8504347 6
9 COSM456125 PTPRD skin,neck,carcinoma,NS c.5048C>T p.S1683F 9:8341168-8341168 6
10 COSM1700914 PTPRD skin,neck,carcinoma,NS c.1261C>T p.P421S 9:8518130-8518130 6
11 COSM17483 PTCH1 skin,neck,carcinoma,NS c.1729-1G>T p.? 9:95469932-95469932 6
12 COSM17468 PTCH1 skin,neck,carcinoma,NS c.584G>T p.R195M 9:95485685-95485685 6
13 COSM29053 PTCH1 skin,neck,carcinoma,NS c.833G>A p.W278* 9:95480502-95480502 6
14 COSM29072 PTCH1 skin,neck,carcinoma,NS c.1067+1G>A p.? 9:95479968-95479968 6
15 COSM14452 PTCH1 skin,neck,carcinoma,NS c.2321G>A p.G774E 9:95467355-95467355 6
16 COSM6962989 PLCG2 skin,neck,carcinoma,NS c.115G>T p.E39* 16:81786104-81786104 6
17 COSM6962963 PIK3CG skin,neck,carcinoma,NS c.310G>A p.G104R 7:106867871-106867871 6
18 COSM6962964 PIK3CG skin,neck,carcinoma,NS c.3227G>A p.R1076K 7:106905305-106905305 6
19 COSM564 NRAS skin,neck,carcinoma,NS c.35G>A p.G12D 1:114716126-114716126 6
20 COSM6962996 NCOA3 skin,neck,carcinoma,NS c.979C>T p.H327Y 20:47634062-47634062 6
21 COSM4170532 MTOR skin,neck,carcinoma,NS c.3409G>A p.E1137K 1:11212464-11212464 6
22 COSM516 KRAS skin,neck,carcinoma,NS c.34G>T p.G12C 12:25245351-25245351 6
23 COSM6962967 KMT2C skin,neck,carcinoma,NS c.11659C>T p.H3887Y 7:152158874-152158874 6
24 COSM6962983 KMT2A skin,neck,carcinoma,NS c.4377T>G p.C1459W 11:118488658-118488658 6
25 COSM498 HRAS skin,neck,carcinoma,NS c.182A>T p.Q61L 11:533874-533874 6
26 COSM6438927 HGF skin,neck,carcinoma,NS c.974C>T p.P325L 7:81729671-81729671 6
27 COSM6962960 FGFR3 skin,neck,carcinoma,NS c.2421A>G p.*807W 4:1807262-1807262 6
28 COSM6962980 FGFR2 skin,neck,carcinoma,NS c.2234C>T p.S745F 10:121483765-121483765 6
29 COSM6962962 EPHA7 skin,neck,carcinoma,NS c.2468G>A p.G823E 6:93254711-93254711 6
30 COSM5918388 EPHA5 skin,neck,carcinoma,NS c.2608G>A p.E870K 4:65348104-65348104 6
31 COSM6962957 EPHA3 skin,neck,carcinoma,NS c.632T>A p.M211K 3:89210338-89210338 6
32 COSM6946976 EPHA3 skin,neck,carcinoma,NS c.533G>A p.G178E 3:89210239-89210239 6
33 COSM6962956 CASP8 skin,neck,carcinoma,NS c.1382C>T p.T461I 2:201286485-201286485 6
34 COSM3713589 CASP8 skin,neck,carcinoma,NS c.1093C>T p.L365F 2:201285055-201285055 6
35 COSM21323 ATM skin,neck,carcinoma,NS c.1009C>T p.R337C 11:108247071-108247071 6
36 COSM6950941 APC skin,neck,carcinoma,NS c.536C>T p.S179F 5:112780794-112780794 6
37 COSM6962953 AKT3 skin,neck,carcinoma,NS c.1164-1G>A p.? 1:243545598-243545598 6
38 COSM6962993 skin,neck,carcinoma,NS c.1619G>A p.G540E 20:42352227-42352227 6
39 COSM99602 skin,neck,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 6
40 COSM1640830 skin,neck,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 6
41 COSM6962972 skin,neck,carcinoma,NS c.1727G>A p.S576N 9:8504347-8504347 6
42 COSM6962978 skin,neck,carcinoma,NS c.2237C>T p.S746F 10:121483765-121483765 6
43 COSM6962995 skin,neck,carcinoma,NS c.1607C>T p.S536L 20:42352239-42352239 6
44 COSM1350749 skin,neck,carcinoma,NS c.1009C>T p.R337C 11:108247071-108247071 6
45 COSM6962951 skin,neck,carcinoma,NS c.1164-1G>A p.? 1:243545598-243545598 6
46 COSM1700913 skin,neck,carcinoma,NS c.1261C>T p.P421S 9:8518130-8518130 6
47 COSM1700915 skin,neck,carcinoma,NS c.1252C>T p.P418S 9:8518130-8518130 6
48 COSM6962982 skin,neck,carcinoma,NS c.4377T>G p.C1459W 11:118488658-118488658 6
49 COSM6962950 skin,neck,carcinoma,NS c.430C>T p.P144S 1:77966737-77966737 6
50 COSM1700912 skin,neck,carcinoma,NS c.1261C>T p.P421S 9:8518130-8518130 6

Expression for Hidradenocarcinoma

Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for Hidradenocarcinoma

Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 BCL2 CCND1 EGFR ERBB2 TP53
2 12.69 BCL2 CCND1 EGFR ERBB2 ESR1 TP53
3
Show member pathways
12.58 BCL2 CCND1 EGFR ERBB2 ESR1 TP53
4 12.42 CCND1 MKI67 TP53 TP63 VIM
5
Show member pathways
12.4 BCL2 CCND1 ERBB2 ESR1
6
Show member pathways
12.38 CCND1 EGFR ERBB2 TP53
7
Show member pathways
12.34 BCL2 EGFR ERBB2 TP53
8
Show member pathways
12.2 CCND1 EGFR ERBB2 ESR1
9 12.07 CCND1 EGFR ERBB2 ESR1 TP53
10 11.98 BCL2 EGFR TP53 TP63
11 11.98 BCL2 CCND1 EGFR ERBB2 TP53 TP63
12
Show member pathways
11.97 CCND1 EGFR ERBB2
13 11.96 BCL2 CCND1 EGFR ERBB2 TP53
14 11.92 CCND1 EGFR TP53 VIM
15 11.89 BCL2 CCND1 ERBB2 TP53
16
Show member pathways
11.89 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
17 11.87 BCL2 CCND1 TP53 VIM
18
Show member pathways
11.86 KRT5 KRT7 VIM
19 11.84 BCL2 CCND1 EGFR ESR1 TP53
20 11.82 BCL2 EGFR ERBB2
21
Show member pathways
11.81 EGFR ERBB2 ESR1 S100B
22 11.78 BCL2 CCND1 TP53
23
Show member pathways
11.78 EGFR ERBB2 ESR1
24 11.64 BCL2 ERBB2 TP53
25
Show member pathways
11.62 CCND1 EGFR ESR1
26 11.59 CCND1 EGFR ESR1
27 11.57 EGFR ERBB2 TP53
28 11.53 BCL2 CCND1 ERBB2
29 11.49 CCND1 EGFR ERBB2 TP53
30 11.16 BCL2 CCND1 EGFR TP53
31
Show member pathways
10.98 BCL2 TP53 TP63

GO Terms for Hidradenocarcinoma

Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.47 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.99 CCND1 CDX2 ESR1 NKX2-1 TP53 TP63
2 negative regulation of apoptotic process GO:0043066 9.97 BCL2 EGFR ERBB2 TP53 TP63
3 positive regulation of cell proliferation GO:0008284 9.95 BCL2 CCND1 CDX2 EGFR S100B
4 positive regulation of transcription, DNA-templated GO:0045893 9.93 CDX2 EGFR ESR1 NKX2-1 TP53 TP63
5 positive regulation of gene expression GO:0010628 9.88 ERBB2 NKX2-1 PIP TP53 VIM
6 phosphatidylinositol phosphorylation GO:0046854 9.8 EGFR ERBB2 ESR1
7 response to estradiol GO:0032355 9.79 CCND1 EGFR ESR1
8 positive regulation of cell growth GO:0030307 9.71 BCL2 EGFR ERBB2
9 animal organ morphogenesis GO:0009887 9.71 BCL2 CDX2 NKX2-1 TP63
10 response to glucocorticoid GO:0051384 9.7 BCL2 CCND1 S100B
11 pattern specification process GO:0007389 9.67 CDX2 NKX2-1 TP63
12 digestive tract morphogenesis GO:0048546 9.61 BCL2 EGFR
13 negative regulation of ERBB signaling pathway GO:1901185 9.61 EGFR ERBB2
14 regulation of mitochondrial membrane permeability GO:0046902 9.6 BCL2 TP53
15 cerebral cortex cell migration GO:0021795 9.59 EGFR NKX2-1
16 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.58 ESR1 TP53
17 epithelial cell development GO:0002064 9.57 ESR1 TP63
18 Leydig cell differentiation GO:0033327 9.56 CCND1 NKX2-1
19 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.54 BCL2 TP53 TP63
20 response to gamma radiation GO:0010332 9.5 BCL2 TP53 TP63
21 response to UV-A GO:0070141 9.43 CCND1 EGFR
22 cell aging GO:0007569 9.43 BCL2 TP53 TP63
23 response to X-ray GO:0010165 9.33 CCND1 TP53 TP63
24 cell proliferation GO:0008283 9.17 BCL2 EGFR ERBB2 MKI67 S100B TP53
25 mitotic G1 DNA damage checkpoint GO:0031571 9.13 CCND1 TP53 TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 BCL2 EGFR ERBB2 ESR1 S100B TP53
2 enzyme binding GO:0019899 9.55 CCND1 EGFR ESR1 NKX2-1 TP53
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.54 EGFR ERBB2 ESR1
4 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.4 EGFR ERBB2
5 nitric-oxide synthase regulator activity GO:0030235 9.32 EGFR ESR1
6 protein phosphatase binding GO:0019903 8.92 BCL2 EGFR ERBB2 TP53
7 protein binding GO:0005515 10.16 BCL2 CCND1 EGFR ERBB2 ESR1 KRT5

Sources for Hidradenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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