MCID: HDR006
MIFTS: 46

Hidradenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Hidradenocarcinoma

MalaCards integrated aliases for Hidradenocarcinoma:

Name: Hidradenocarcinoma 53
Primary Mucoepidermoid Cutaneous Carcinoma 53
Malignant Nodular/clear Cell Hidradenoma 53
Malignant Clear Cell Acrospiroma 53
Clear Cell Eccrine Carcinoma 53
Sweat Gland Adenocarcinoma 73
Eccrine Ductal Carcinoma 73
Malignant Acrospiroma 53

Classifications:



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Summaries for Hidradenocarcinoma

NIH Rare Diseases : 53 Hidradenocarcinoma is a rare tumor caused by the abnormal growth of cells in a sweat gland.  It is a type of cancer that usually begins as a single spot (lesion) on the skin of the head or neck, but can be been found on other parts of the body. This type of tumor most often develops in people between the ages of 30-60 years old, but has been found in children.  Hidradenocarcinoma is usually painless and tends to grow slowly, but may spread into nearby tissues, especially lymph nodes, or to more distant parts of the body (metastasis). The cause of the tumor is unknown. Diagnosis is usually made by careful examination and a series of special skin tests. The main treatment is surgical removal of the tumor often followed by radiation therapy and/or chemotherapy. Long term outlook is best when the cancer is found early.

MalaCards based summary : Hidradenocarcinoma, also known as primary mucoepidermoid cutaneous carcinoma, is related to eccrine porocarcinoma and nodular hidradenoma. An important gene associated with Hidradenocarcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine... more...

Related Diseases for Hidradenocarcinoma

Diseases related to Hidradenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 302)
# Related Disease Score Top Affiliating Genes
1 eccrine porocarcinoma 31.9 S100B VIM
2 nodular hidradenoma 30.5 KRT7 PIP VIM
3 vulvar clear cell hidradenocarcinoma 12.1
4 malignant acrospiroma 11.1
5 acrospiroma 10.4
6 hidradenoma 10.4
7 breast neuroendocrine neoplasm 10.4 ERBB2 PIP
8 breast papillomatosis 10.3 CCND1 ERBB2
9 progesterone-receptor positive breast cancer 10.3 ERBB2 ESR1
10 progesterone-receptor negative breast cancer 10.3 EGFR ERBB2
11 breast medullary carcinoma 10.3 ERBB2 ESR1
12 comedo carcinoma 10.3 ERBB2 ESR1
13 glassy cell carcinoma of the cervix 10.3 ERBB2 ESR1
14 breast intraductal proliferative lesion 10.3 EGFR ERBB2
15 glomangiomyoma 10.3 ESR1 VIM
16 endometrial squamous cell carcinoma 10.3 CCND1 ESR1
17 lymphoma, small cleaved-cell, diffuse 10.3 BCL2 CCND1
18 breast metaplastic carcinoma 10.3 ERBB2 KRT5
19 malignant peritoneal mesothelioma 10.3 EGFR VIM
20 extramedullary plasmacytoma 10.3 BCL2 CCND1
21 breast cystic hypersecretory carcinoma 10.3 ERBB2 KRT5
22 large intestine adenocarcinoma 10.3 KRT7 PIP
23 cutaneous adenocystic carcinoma 10.3 KRT7 PIP
24 parachordoma 10.3 KRT7 VIM
25 secretory meningioma 10.3 KRT7 VIM
26 adenoid squamous cell carcinoma 10.3 KRT7 VIM
27 glandular cystitis 10.3 CDX2 KRT7
28 ovary neuroendocrine neoplasm 10.3 CDX2 KRT7
29 appendix adenocarcinoma 10.3 CDX2 KRT7
30 epithelial predominant wilms' tumor 10.3 CDX2 KRT7
31 sensory organ benign neoplasm 10.3 KRT5 KRT7
32 balloon cell malignant melanoma 10.3 KRT5 KRT7
33 benign mesothelioma 10.3 KRT5 KRT7
34 large cell acanthoma 10.3 KRT5 KRT7
35 inverted transitional papilloma 10.3 KRT5 KRT7
36 middle ear adenoma 10.3 KRT5 KRT7
37 apocrine sweat gland neoplasm 10.3 KRT5 KRT7
38 cystic basal cell carcinoma 10.2 KRT7 TP63
39 ovarian germ cell cancer 10.2 KRT7 NKX2-1
40 ovarian germ cell teratoma 10.2 KRT7 NKX2-1
41 lung acinar adenocarcinoma 10.2 KRT7 NKX2-1
42 small cell carcinoma of the bladder 10.2 KRT7 NKX2-1
43 hemangioma of lung 10.2 NKX2-1 TP63
44 chondromyxoid fibroma 10.2 BCL2 CCND1 VIM
45 ossifying fibromyxoid tumor 10.2 S100B VIM
46 sarcoma, synovial 10.2 BCL2 KRT7 VIM
47 syringocystadenoma papilliferum 10.2 S100B VIM
48 fibrous meningioma 10.2 S100B VIM
49 chordoid meningioma 10.2 S100B VIM
50 bednar tumor 10.2 S100B VIM

Graphical network of the top 20 diseases related to Hidradenocarcinoma:



Diseases related to Hidradenocarcinoma

Symptoms & Phenotypes for Hidradenocarcinoma

GenomeRNAi Phenotypes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 33)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.92 S100B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.92 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.92 BCL2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.92 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.92 BCL2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.92 EGFR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.92 BCL2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.92 VIM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.92 BCL2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.92 ERBB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.92 ERBB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.92 ERBB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.92 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.92 BCL2 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.92 VIM
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.92 EGFR VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.92 BCL2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.92 BCL2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.92 ERBB2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.92 EGFR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.92 BCL2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.92 EGFR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.92 VIM
24 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.92 VIM
25 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.92 ERBB2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.92 BCL2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.92 EGFR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.92 ERBB2 S100B VIM
29 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.92 BCL2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.92 BCL2 EGFR ERBB2 S100B VIM
31 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.92 BCL2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.92 BCL2
33 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 CCND1 ESR1 MKI67 PIP

MGI Mouse Phenotypes related to Hidradenocarcinoma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.39 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
2 digestive/alimentary MP:0005381 10.37 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
3 cardiovascular system MP:0005385 10.36 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
4 homeostasis/metabolism MP:0005376 10.36 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
5 behavior/neurological MP:0005386 10.33 BCL2 CCND1 ERBB2 ESR1 KRT5 MUC5AC
6 endocrine/exocrine gland MP:0005379 10.28 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
7 growth/size/body region MP:0005378 10.26 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
8 mortality/aging MP:0010768 10.21 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
9 immune system MP:0005387 10.19 BCL2 CCND1 EGFR ESR1 MUC2 MUC5AC
10 embryo MP:0005380 10.15 BCL2 CDX2 EGFR ERBB2 ESR1 TP53
11 integument MP:0010771 10.13 BCL2 CCND1 EGFR ERBB2 ESR1 KRT5
12 craniofacial MP:0005382 10.11 BCL2 CCND1 EGFR ERBB2 KRT5 TP53
13 neoplasm MP:0002006 10.07 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
14 limbs/digits/tail MP:0005371 10 CDX2 EGFR ERBB2 ESR1 KRT5 TP53
15 normal MP:0002873 9.96 CCND1 CDX2 EGFR ERBB2 ESR1 MKI67
16 muscle MP:0005369 9.95 BCL2 EGFR ERBB2 ESR1 TP53 TP63
17 reproductive system MP:0005389 9.9 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
18 no phenotypic analysis MP:0003012 9.87 EGFR ESR1 KRT5 MKI67 NKX2-1 TP53
19 respiratory system MP:0005388 9.56 CCND1 EGFR ERBB2 ESR1 NKX2-1 TP53
20 skeleton MP:0005390 9.23 CCND1 CDX2 EGFR ERBB2 ESR1 NKX2-1

Drugs & Therapeutics for Hidradenocarcinoma

Drugs for Hidradenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Antibodies Phase 2
4 Immunoglobulins Phase 2
5 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Hidradenocarcinoma

Genetic Tests for Hidradenocarcinoma

Anatomical Context for Hidradenocarcinoma

MalaCards organs/tissues related to Hidradenocarcinoma:

41
Skin, Lymph Node, Testes, Lung, Ovary, Prostate, Appendix

Publications for Hidradenocarcinoma

Articles related to Hidradenocarcinoma:

(show top 50) (show all 61)
# Title Authors Year
1
A rare presentation of hidradenocarcinoma within the penis. ( 30510902 )
2019
2
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. ( 29166328 )
2018
3
Malignant Hidradenocarcinoma in the Lower Extremity: A Case Report of a Rare Tumor. ( 29472169 )
2018
4
Hidradenocarcinoma: Five Years of Local and Systemic Control of a Rare Sweat Gland Neoplasm with Nodal Metastasis. ( 30155386 )
2018
5
Hidradenocarcinoma of the Dorsum of the Hand. ( 28685735 )
2017
6
Translocation of the MAML2 gene in hidradenocarcinoma. ( 28295544 )
2017
7
Complete response in a patient with gynecological hidradenocarcinoma treated with exclusive external beam radiotherapy and brachytherapy: a case report. ( 29441103 )
2017
8
Perianal eccrine hidradenocarcinoma in the context of a fistulising Crohn's disease. ( 28827020 )
2017
9
Fatal hidradenocarcinoma of the scalp: A case report. ( 28410954 )
2017
10
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis. ( 26876052 )
2016
11
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. ( 26500736 )
2015
12
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. ( 25815059 )
2015
13
Case report: clear cell hidradenocarcinoma of the nail bed. ( 26416223 )
2015
14
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. ( 25918615 )
2015
15
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. ( 26288440 )
2015
16
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. ( 26319286 )
2015
17
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. ( 25627632 )
2015
18
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. ( 25513929 )
2014
19
Clear cell hidradenocarcinoma of the ear helix: report of primary ear helix adnexal carcinoma with regional lymph node metastasis. ( 25006935 )
2014
20
Clear cell hidradenocarcinoma mimicking pyogenic granuloma after repeated surgical excision. ( 24490986 )
2014
21
Hidradenocarcinoma of the chest. ( 25382529 )
2014
22
Hidradenocarcinoma of the Finger. ( 23486133 )
2013
23
Clear cell hidradenocarcinoma of the eyelid: a case report with a review of the literature. ( 23053773 )
2013
24
Clear cell hidradenocarcinoma with helpful immunohistochemistry: a case report. ( 22998159 )
2013
25
Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells. ( 23489214 )
2013
26
Hidradenocarcinoma of the temporal area successfully treated with concomitant electrochemotherapy and radiotherapy. ( 23466792 )
2013
27
Clear cell hidradenocarcinoma of the breast: a very rare breast skin tumor. ( 22678002 )
2012
28
No sweat, a rare case of hidradenocarcinoma. ( 22369809 )
2012
29
Diagnosis and treatment of clear cell hidradenocarcinoma of the scalp. ( 23271300 )
2012
30
Hidradenocarcinoma of the fingertip: a case report and literature review. ( 21489038 )
2011
31
Radiotherapy on hidradenocarcinoma. ( 22540063 )
2011
32
F-18 FDG PET/CT imaging of a hidradenocarcinoma of head and neck. ( 21892057 )
2011
33
Complete response of metastatic malignant hidradenocarcinoma to capecitabine treatment. ( 21844475 )
2011
34
Mohs micrographic surgery for hidradenocarcinoma on a rhinophymatous nose: a histologic conundrum. ( 21044227 )
2010
35
Perianal nodular hidradenocarcinoma. Case report. ( 20478121 )
2010
36
Hidradenocarcinoma eccrinale syringomatodes of the eyelid--case of a rare malignancy. ( 20572504 )
2010
37
Sunitinib efficacy in the treatment of metastatic skin adnexal carcinomas: report of two patients with hidradenocarcinoma and trichoblastic carcinoma. ( 19522717 )
2010
38
Apocrine hidradenocarcinoma showing Paget's disease and mucinous metaplasia. ( 19476529 )
2009
39
Hidradenomas and a hidradenocarcinoma of the scalp managed using Mohs micrographic surgery and a multidisciplinary approach: case reports and review of the literature. ( 19215270 )
2009
40
Metastatic hidradenocarcinoma: Surgery and chemotherapy. ( 22666726 )
2009
41
Apocrine hidradenocarcinoma of the scalp: a classification conundrum. ( 20596988 )
2009
42
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. ( 19384064 )
2009
43
Mechanistic and Treatment Implications of DeltaNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma. ( 20740144 )
2009
44
Clear cell hidradenocarcinoma developing in pacemaker pocket. ( 18950311 )
2008
45
Nodular hidradenocarcinoma over the parotid gland: a pathologic presentation. ( 17103407 )
2007
46
Metastatic hidradenocarcinoma: efficacy of capecitabine. ( 17043204 )
2006
47
Hidradenocarcinoma: a histological and immunohistochemical study. ( 17083691 )
2006
48
Nodular hidradenocarcinoma on the scalp of a young woman: case report and review of literature. ( 15355375 )
2004
49
Nodular hidradenocarcinoma with prominent squamous differentiation: case report and immunohistochemical study. ( 10955691 )
2000
50
Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma. ( 9788267 )
1998

Variations for Hidradenocarcinoma

Cosmic variations for Hidradenocarcinoma:

9 (show top 50) (show all 82)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10662 TP53 skin,neck,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 6
2 COSM607136 TGFBR1 skin,neck,carcinoma,NS c.1247C>T p.S416F 9:99146601-99146601 6
3 COSM6962965 SMO skin,neck,carcinoma,NS c.1103C>T p.P368L 7:129206332-129206332 6
4 COSM6962990 RARA skin,neck,carcinoma,NS c.1384C>T p.P462S 17:40356221-40356221 6
5 COSM6962984 RAD52 skin,neck,carcinoma,NS c.439G>A p.V147M 12:927173-927173 6
6 COSM6962994 PTPRT skin,neck,carcinoma,NS c.1607C>T p.S536L 20:42352239-42352239 6
7 COSM6962992 PTPRT skin,neck,carcinoma,NS c.1619G>A p.G540E 20:42352227-42352227 6
8 COSM6962970 PTPRD skin,neck,carcinoma,NS c.1736G>A p.S579N 9:8504347-8504347 6
9 COSM456125 PTPRD skin,neck,carcinoma,NS c.5048C>T p.S1683F 9:8341168-8341168 6
10 COSM1700914 PTPRD skin,neck,carcinoma,NS c.1261C>T p.P421S 9:8518130-8518130 6
11 COSM17483 PTCH1 skin,neck,carcinoma,NS c.1729-1G>T p.? 9:95469932-95469932 6
12 COSM17468 PTCH1 skin,neck,carcinoma,NS c.584G>T p.R195M 9:95485685-95485685 6
13 COSM29053 PTCH1 skin,neck,carcinoma,NS c.833G>A p.W278* 9:95480502-95480502 6
14 COSM29072 PTCH1 skin,neck,carcinoma,NS c.1067+1G>A p.? 9:95479968-95479968 6
15 COSM14452 PTCH1 skin,neck,carcinoma,NS c.2321G>A p.G774E 9:95467355-95467355 6
16 COSM6962989 PLCG2 skin,neck,carcinoma,NS c.115G>T p.E39* 16:81786104-81786104 6
17 COSM6962963 PIK3CG skin,neck,carcinoma,NS c.310G>A p.G104R 7:106867871-106867871 6
18 COSM6962964 PIK3CG skin,neck,carcinoma,NS c.3227G>A p.R1076K 7:106905305-106905305 6
19 COSM564 NRAS skin,neck,carcinoma,NS c.35G>A p.G12D 1:114716126-114716126 6
20 COSM6962996 NCOA3 skin,neck,carcinoma,NS c.979C>T p.H327Y 20:47634062-47634062 6
21 COSM4170532 MTOR skin,neck,carcinoma,NS c.3409G>A p.E1137K 1:11212464-11212464 6
22 COSM516 KRAS skin,neck,carcinoma,NS c.34G>T p.G12C 12:25245351-25245351 6
23 COSM6962967 KMT2C skin,neck,carcinoma,NS c.11659C>T p.H3887Y 7:152158874-152158874 6
24 COSM6962983 KMT2A skin,neck,carcinoma,NS c.4377T>G p.C1459W 11:118488658-118488658 6
25 COSM498 HRAS skin,neck,carcinoma,NS c.182A>T p.Q61L 11:533874-533874 6
26 COSM6438927 HGF skin,neck,carcinoma,NS c.974C>T p.P325L 7:81729671-81729671 6
27 COSM6962960 FGFR3 skin,neck,carcinoma,NS c.2421A>G p.*807W 4:1807262-1807262 6
28 COSM6962980 FGFR2 skin,neck,carcinoma,NS c.2234C>T p.S745F 10:121483765-121483765 6
29 COSM6962962 EPHA7 skin,neck,carcinoma,NS c.2468G>A p.G823E 6:93254711-93254711 6
30 COSM5918388 EPHA5 skin,neck,carcinoma,NS c.2608G>A p.E870K 4:65348104-65348104 6
31 COSM6962957 EPHA3 skin,neck,carcinoma,NS c.632T>A p.M211K 3:89210338-89210338 6
32 COSM6946976 EPHA3 skin,neck,carcinoma,NS c.533G>A p.G178E 3:89210239-89210239 6
33 COSM6962956 CASP8 skin,neck,carcinoma,NS c.1382C>T p.T461I 2:201286485-201286485 6
34 COSM3713589 CASP8 skin,neck,carcinoma,NS c.1093C>T p.L365F 2:201285055-201285055 6
35 COSM21323 ATM skin,neck,carcinoma,NS c.1009C>T p.R337C 11:108247071-108247071 6
36 COSM6950941 APC skin,neck,carcinoma,NS c.536C>T p.S179F 5:112780794-112780794 6
37 COSM6962953 AKT3 skin,neck,carcinoma,NS c.1164-1G>A p.? 1:243545598-243545598 6
38 COSM6962993 skin,neck,carcinoma,NS c.1619G>A p.G540E 20:42352227-42352227 6
39 COSM1640830 skin,neck,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 6
40 COSM6962974 skin,neck,carcinoma,NS c.1231C>T p.P411S 9:8518130-8518130 6
41 COSM6962968 skin,neck,carcinoma,NS c.1736G>A p.S579N 9:8504347-8504347 6
42 COSM6962949 skin,neck,carcinoma,NS c.493C>T p.P165S 1:77966737-77966737 6
43 COSM6962972 skin,neck,carcinoma,NS c.1727G>A p.S576N 9:8504347-8504347 6
44 COSM6962978 skin,neck,carcinoma,NS c.2237C>T p.S746F 10:121483765-121483765 6
45 COSM6962995 skin,neck,carcinoma,NS c.1607C>T p.S536L 20:42352239-42352239 6
46 COSM1350749 skin,neck,carcinoma,NS c.1009C>T p.R337C 11:108247071-108247071 6
47 COSM6962951 skin,neck,carcinoma,NS c.1164-1G>A p.? 1:243545598-243545598 6
48 COSM1700913 skin,neck,carcinoma,NS c.1261C>T p.P421S 9:8518130-8518130 6
49 COSM1700915 skin,neck,carcinoma,NS c.1252C>T p.P418S 9:8518130-8518130 6
50 COSM6962982 skin,neck,carcinoma,NS c.4377T>G p.C1459W 11:118488658-118488658 6

Expression for Hidradenocarcinoma

Search GEO for disease gene expression data for Hidradenocarcinoma.

Pathways for Hidradenocarcinoma

Pathways related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 BCL2 CCND1 EGFR ERBB2 TP53
2 12.71 BCL2 CCND1 EGFR ERBB2 ESR1 TP53
3
Show member pathways
12.58 BCL2 CCND1 EGFR ERBB2 ESR1 TP53
4
Show member pathways
12.45 CCND1 EGFR ERBB2 TP53
5 12.43 CCND1 MKI67 TP53 TP63 VIM
6
Show member pathways
12.4 BCL2 CCND1 ERBB2 ESR1
7
Show member pathways
12.39 CCND1 EGFR ERBB2 TP53
8
Show member pathways
12.35 BCL2 EGFR ERBB2 TP53
9
Show member pathways
12.22 CCND1 EGFR ERBB2 ESR1
10 12.18 BCL2 CCND1 TP53 VIM
11 12.11 CCND1 EGFR ERBB2 ESR1 TP53
12
Show member pathways
12.06 BCL2 CCND1 EGFR ERBB2 TP53
13 11.99 BCL2 EGFR TP53 TP63
14 11.98 BCL2 CCND1 EGFR ERBB2 TP53 TP63
15 11.93 CCND1 EGFR TP53 VIM
16 11.9 BCL2 CCND1 ERBB2 TP53
17
Show member pathways
11.89 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
18 11.88 CCND1 EGFR TP53
19 11.88 BCL2 CCND1 TP53 VIM
20
Show member pathways
11.87 KRT5 KRT7 VIM
21 11.87 BCL2 CCND1 EGFR ERBB2 TP53
22 11.84 BCL2 CCND1 EGFR ESR1 TP53
23 11.83 BCL2 EGFR ERBB2
24
Show member pathways
11.83 EGFR ERBB2 ESR1 S100B
25 11.79 BCL2 CCND1 TP53
26
Show member pathways
11.79 EGFR ERBB2 ESR1
27 11.66 BCL2 ERBB2 TP53
28
Show member pathways
11.63 CCND1 EGFR ESR1
29 11.6 CCND1 EGFR ESR1
30 11.59 EGFR ERBB2 TP53
31 11.55 BCL2 CCND1 ERBB2
32 11.53 CCND1 EGFR ERBB2 TP53
33 11.16 BCL2 CCND1 EGFR TP53
34
Show member pathways
10.98 BCL2 TP53 TP63
35 10.93 BCL2 EGFR ERBB2 PIP VIM

GO Terms for Hidradenocarcinoma

Cellular components related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 BCL2 CCND1 CDX2 EGFR ERBB2 ESR1
2 protein-containing complex GO:0032991 9.43 BCL2 CDX2 EGFR ESR1 TP53 TP63

Biological processes related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.95 BCL2 CCND1 CDX2 EGFR S100B
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.93 CCND1 CDX2 ESR1 NKX2-1 TP53 TP63
3 cytokine-mediated signaling pathway GO:0019221 9.91 BCL2 CCND1 TP53 VIM
4 regulation of apoptotic process GO:0042981 9.9 BCL2 ESR1 TP53 TP63
5 positive regulation of transcription, DNA-templated GO:0045893 9.85 CDX2 EGFR ESR1 NKX2-1 TP53 TP63
6 epidermis development GO:0008544 9.8 EGFR KRT5 TP63
7 positive regulation of gene expression GO:0010628 9.8 ERBB2 NKX2-1 PIP TP53 VIM
8 response to estradiol GO:0032355 9.79 CCND1 EGFR ESR1
9 positive regulation of cell growth GO:0030307 9.71 BCL2 EGFR ERBB2
10 response to glucocorticoid GO:0051384 9.67 BCL2 CCND1 S100B
11 pattern specification process GO:0007389 9.65 CDX2 NKX2-1 TP63
12 digestive tract morphogenesis GO:0048546 9.61 BCL2 EGFR
13 cerebral cortex cell migration GO:0021795 9.59 EGFR NKX2-1
14 epithelial cell development GO:0002064 9.58 ESR1 TP63
15 Leydig cell differentiation GO:0033327 9.58 CCND1 NKX2-1
16 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.57 ESR1 TP53
17 regulation of mitochondrial membrane permeability GO:0046902 9.56 BCL2 TP53
18 animal organ morphogenesis GO:0009887 9.56 BCL2 CDX2 NKX2-1 TP63
19 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.52 EGFR TP53
20 mitotic G1 DNA damage checkpoint GO:0031571 9.51 CCND1 TP53
21 negative regulation of ERBB signaling pathway GO:1901185 9.43 EGFR ERBB2
22 cell aging GO:0007569 9.33 BCL2 TP53 TP63
23 response to UV-A GO:0070141 9.32 CCND1 EGFR
24 cell proliferation GO:0008283 9.17 BCL2 EGFR ERBB2 MKI67 S100B TP53
25 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.13 BCL2 TP53 TP63

Molecular functions related to Hidradenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.83 BCL2 CDX2 ESR1 NKX2-1 TP63
2 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.58 CDX2 NKX2-1 TP53
3 enzyme binding GO:0019899 9.55 CCND1 EGFR ESR1 NKX2-1 TP53
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 EGFR ERBB2 ESR1
5 nitric-oxide synthase regulator activity GO:0030235 9.32 EGFR ESR1
6 protein phosphatase binding GO:0019903 9.26 BCL2 EGFR ERBB2 TP53
7 identical protein binding GO:0042802 9.23 BCL2 EGFR ERBB2 ESR1 S100B TP53
8 protein binding GO:0005515 10.24 BCL2 CCND1 EGFR ERBB2 ESR1 KRT5

Sources for Hidradenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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