MCID: HDR004
MIFTS: 42

Hidradenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Hidradenoma

MalaCards integrated aliases for Hidradenoma:

Name: Hidradenoma 12 56 15
Adenoma, Sweat Gland 45 74
Benign Neoplasm of Sweat Gland 74
Hidradenoma of Skin 12
Sweat Gland Adenoma 12
Eccrine Acrospiroma 74
Syringoadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3896
MeSH 45 D006607
NCIt 51 C7563
SNOMED-CT 69 81393009

Summaries for Hidradenoma

Disease Ontology : 12 A sweat gland neoplasm that is located in an apical sweat gland.

MalaCards based summary : Hidradenoma, also known as adenoma, sweat gland, is related to nodular hidradenoma and hidradenocarcinoma. An important gene associated with Hidradenoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are T cell receptor signaling pathway and Integrins in angiogenesis. Affiliated tissues include skin, breast and lung, and related phenotype is Decreased cell migration.

Wikipedia : 77 Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. These are 1–3 cm translucent... more...

Related Diseases for Hidradenoma

Diseases related to Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 nodular hidradenoma 33.2 KRT7 MUC1 VIM
2 hidradenocarcinoma 32.9 KRT7 VIM
3 syringocystadenoma papilliferum 32.5 MUC1 VIM
4 syringoma 30.6 MUC1 VIM
5 adenocarcinoma 30.4 AKT1 MUC1 PIK3CA
6 cystadenoma 30.1 KRT7 MUC1
7 spiradenoma 29.9 KRT7 MUC1
8 paget disease, extramammary 29.9 KRT7 MUC1
9 mammary paget's disease 29.7 KRT7 MUC1
10 mucoepidermoid carcinoma 29.6 KRT7 MAML2 MUC1
11 adenosquamous carcinoma 29.6 KRT7 MUC1 PIK3CA
12 dermoid cyst 29.5 KRT7 MUC1 VIM
13 clear cell renal cell carcinoma 29.5 KRT7 MUC1 VIM
14 renal cell carcinoma, nonpapillary 29.1 KRT7 MUC1 VIM
15 papillary hidradenoma 12.5
16 clear cell hidradenoma 12.3
17 vulvar nodular hidradenoma 12.1
18 eccrine acrospiroma 12.0
19 acrospiroma 11.4
20 breast mucoepidermoid carcinoma 10.4 MAML2 MUC1
21 apocrine adenoma 10.3 MUC1 PIK3CA
22 aggressive digital papillary adenocarcinoma 10.3 MUC1 PIK3CA
23 rare adenocarcinoma of the breast 10.3 AKT1 PIK3CA
24 anal squamous cell carcinoma 10.3 AKT1 PIK3CA
25 malignant peritoneal mesothelioma 10.3 MUC1 VIM
26 papillary tumor of the pineal region 10.3 MUC1 VIM
27 fibrous meningioma 10.3 MUC1 VIM
28 chordoid meningioma 10.3 MUC1 VIM
29 clear cell ependymoma 10.3 MUC1 VIM
30 eccrine porocarcinoma 10.3 MUC1 VIM
31 endometrial mucinous adenocarcinoma 10.3 MUC1 VIM
32 biphasic synovial sarcoma 10.3 MUC1 VIM
33 adenofibroma 10.3 MUC1 VIM
34 clear cell meningioma 10.3 MUC1 VIM
35 myxopapillary ependymoma 10.3 MUC1 VIM
36 pleomorphic liposarcoma 10.2 MUC1 VIM
37 desmoplastic small round cell tumor 10.2 MUC1 VIM
38 perivascular epithelioid cell tumor 10.2 MUC1 VIM
39 anaplastic ependymoma 10.2 MUC1 VIM
40 reticulum cell sarcoma 10.2 MUC1 VIM
41 sertoli cell tumor 10.2 MUC1 VIM
42 mesenchymal chondrosarcoma 10.2 MUC1 VIM
43 brachydactyly, type e1 10.2 AKT1 MUC1
44 extraskeletal ewing sarcoma 10.2 MUC1 VIM
45 perineurioma 10.2 MUC1 VIM
46 chondroid chordoma 10.2 MUC1 VIM
47 lymphangioma 10.2 PIK3CA VIM
48 dendritic cell tumor 10.2 MUC1 VIM
49 cerebral primitive neuroectodermal tumor 10.2 MUC1 VIM
50 proteus syndrome 10.2 AKT1 PIK3CA

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to Hidradenoma

Symptoms & Phenotypes for Hidradenoma

GenomeRNAi Phenotypes related to Hidradenoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.92 AKT1 MUC1 PIK3CA VIM

Drugs & Therapeutics for Hidradenoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Radiotherapy and Panitumumab in Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab

Search NIH Clinical Center for Hidradenoma

Cochrane evidence based reviews: adenoma, sweat gland

Genetic Tests for Hidradenoma

Anatomical Context for Hidradenoma

MalaCards organs/tissues related to Hidradenoma:

42
Skin, Breast, Lung, Ovary, Salivary Gland, Lymph Node, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Hidradenoma:

20
An Apical Sweat Gl

Publications for Hidradenoma

Articles related to Hidradenoma:

(show top 50) (show all 335)
# Title Authors Year
1
"Hidradenoma of the breast: Magnetic resonance (MR) imaging and ultrasonography (US) findings of this rare mass". ( 30761677 )
2019
2
Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network. ( 31010589 )
2019
3
Poroid hidradenoma of the scalp in an immunosuppressed patient. ( 31086655 )
2019
4
Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging. ( 29388236 )
2018
5
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. ( 29166328 )
2018
6
A Nodular Hidradenoma of Atypical Location in Pregnancy. ( 29856466 )
2018
7
Erratum: Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 29898286 )
2018
8
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. ( 29924021 )
2018
9
Ectopic hidradenoma papilliferum. ( 29924236 )
2018
10
Malignant Transformation of Nodular Hidradenoma in the Lower Leg. ( 29928207 )
2018
11
Hidradenoma papilliferum: an unusual benign perianal tumour. ( 30061121 )
2018
12
A case of cutaneous metastatic lung cancer difficult to distinguish from malignant nodular hidradenoma. ( 28664659 )
2018
13
Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 28772003 )
2018
14
Sonographic Characteristics of Apocrine Nodular Hidradenoma of the Skin. ( 28880402 )
2018
15
Ultrasound Diagnosis of Nodular Hidradenoma. ( 29183622 )
2018
16
Ectopic hidradenoma papilliferum of eyelid: A rare entity with diagnostic challenge. ( 29676381 )
2018
17
Poroid hidradenoma in the hand: A case report and systematic review. ( 29781229 )
2018
18
Large Eccrine Acrospiroma of the Hand. ( 28892973 )
2017
19
Malignant Clear Cell Hidradenoma of the Breast. ( 28409065 )
2017
20
Clear cell hidradenoma of the breast with MAML2 gene rearrangement. ( 27914681 )
2017
21
The utility of using immunohistochemistry in the differentiation of metastatic, cutaneous clear cell renal cell carcinoma and clear cell hidradenoma. ( 28374447 )
2017
22
Nodular hidradenoma arising on the site of a BCG scar. ( 27523405 )
2017
23
PIK3CA and AKT1 mutations in hidradenoma papilliferum. ( 27742746 )
2017
24
Mutations of cancer-related genes in benign tumors: the example of hidradenoma papilliferum. ( 27865794 )
2017
25
Tubulopapillary Hidradenoma-like Tumour of the Mandible: A Case Report and Literature Review. ( 27943162 )
2017
26
Rare Adnexal Tumor of the Breast: Poroid Hidradenoma. ( 27943519 )
2017
27
Lymph Node Involvement by a Clear Cell Nodular Hidradenoma-Like Tumor of Uncertain Malignant Potential. ( 28033155 )
2017
28
A rare case of cutaneous oncocytic hidradenoma. ( 28035705 )
2017
29
Nodular hidradenoma: Dermoscopic presentation. ( 28087028 )
2017
30
Poroid Hidradenoma: An Uncommon Cutaneous Adnexal Neoplasm. ( 28216741 )
2017
31
Hidradenoma papilliferum of the vulva in a postpartum woman: A case report. ( 28287283 )
2017
32
Mucinous hidradenoma in a child-A case report and review of the literature. ( 28429507 )
2017
33
Hidradenoma of the Chin. ( 28570408 )
2017
34
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. ( 28648934 )
2017
35
A Large Lumbar Adnexal Neoplasm Presenting Characteristics of Eccrine Poroma and Poroid Hidradenoma. ( 29057137 )
2017
36
A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance. ( 29079171 )
2017
37
Lymph node location of a clear cell hidradenoma: report of a patient and review of literature. ( 27080562 )
2016
38
Hidradenoma papilliferum: diagnostic challenge. ( 25387849 )
2016
39
A reddish nodule with viscous fluid secretion. Solid–cystic hidradenoma (SCH). ( 26266940 )
2016
40
Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma. ( 26493284 )
2016
41
Dermoscopy of Nodular Hidradenoma, a Great Masquerader: A Morphological Study of 28 Cases. ( 26606241 )
2016
42
Ultrasonographic diagnosis of nodular hidradenoma. ( 26662046 )
2016
43
Ultrasound Image of Poroid Hidradenoma. ( 26762692 )
2016
44
Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations. ( 26863059 )
2016
45
Hidradenoma Papilliferum: A Case Report of an Uncommon Perianal Lesion. ( 26874122 )
2016
46
Vulvar hidradenoma papilliferum (HP) is located on the sites of mammary-like anogenital glands (MLAGs): Analysis of the photographs of 52 tumors. ( 26944596 )
2016
47
Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up. ( 27010690 )
2016
48
Hidradenoma Papilliferum With Oncocytic Metaplasia: A Histopathological and Immunohistochemical Study. ( 27097337 )
2016
49
Frequent PIK3CA-activating mutations in hidradenoma papilliferums. ( 27184479 )
2016
50
A Weeping Tumor in a Young Girl: An Unusual Presentation of Nodular Hidradenoma. ( 27293255 )
2016

Variations for Hidradenoma

Expression for Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for Hidradenoma

Pathways related to Hidradenoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 AKT1 PIK3CA VIM
2 11.26 AKT1 PIK3CA
3 11.23 AKT1 PIK3CA
4 11.22 AKT1 PIK3CA
5 11.1 AKT1 PIK3CA
6 11.08 AKT1 PIK3CA
7
Show member pathways
11.07 AKT1 PIK3CA
8 11.04 AKT1 PIK3CA
9 11.02 AKT1 PIK3CA
10 10.99 AKT1 PIK3CA
11 10.96 AKT1 PIK3CA
12 10.92 AKT1 PIK3CA
13 10.87 AKT1 PIK3CA
14 10.86 AKT1 MUC1 VIM
15 10.85 AKT1 PIK3CA
16 10.78 AKT1 PIK3CA
17 10.73 AKT1 PIK3CA
18 10.68 AKT1 PIK3CA
19 10.54 AKT1 PIK3CA
20 10.41 AKT1 PIK3CA
21 10.21 AKT1 VIM

GO Terms for Hidradenoma

Biological processes related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase B signaling GO:0043491 9.32 AKT1 PIK3CA
2 phosphatidylinositol 3-kinase signaling GO:0014065 9.26 AKT1 PIK3CA
3 negative regulation of macroautophagy GO:0016242 9.16 AKT1 PIK3CA
4 anoikis GO:0043276 8.96 AKT1 PIK3CA
5 cytokine-mediated signaling pathway GO:0019221 8.92 AKT1 MUC1 PIK3CA VIM

Sources for Hidradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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