MCID: HDR004
MIFTS: 43

Hidradenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Hidradenoma

MalaCards integrated aliases for Hidradenoma:

Name: Hidradenoma 12 55 15
Adenoma, Sweat Gland 44 73
Benign Neoplasm of Sweat Gland 73
Hidradenoma of Skin 12
Sweat Gland Adenoma 12
Eccrine Acrospiroma 73
Syringoadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3896
MeSH 44 D006607
NCIt 50 C7560 C7563
SNOMED-CT 68 81393009

Summaries for Hidradenoma

Disease Ontology : 12 An adenoma that is located in an apical sweat gland.

MalaCards based summary : Hidradenoma, also known as adenoma, sweat gland, is related to papillary hidradenoma and nodular hidradenoma. An important gene associated with Hidradenoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are Development EGFR signaling pathway and Cytoskeletal Signaling. Affiliated tissues include skin, breast and salivary gland, and related phenotype is Decreased cell migration.

Wikipedia : 76 Hidradenoma (also known as acrospiroma, from akral "peripheral" + spiroma "epithelial tumor of sweat... more...

Related Diseases for Hidradenoma

Diseases related to Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 papillary hidradenoma 33.9 ANXA11 PIK3CA
2 nodular hidradenoma 33.3 KRT7 MUC1 VIM
3 hidradenocarcinoma 33.0 KRT7 VIM
4 syringocystadenoma papilliferum 32.3 MUC1 VIM
5 syringoma 30.4 MUC1 VIM
6 adenocarcinoma 30.3 AKT1 MUC1 PIK3CA
7 cystadenoma 30.1 KRT7 MUC1
8 spiradenoma 29.9 KRT7 VIM
9 mucoepidermoid carcinoma 29.7 KRT7 MAML2 MUC1
10 adenosquamous carcinoma 29.7 KRT7 MUC1 PIK3CA
11 dermoid cyst 29.6 KRT7 MUC1 VIM
12 clear cell renal cell carcinoma 29.6 KRT7 MUC1 VIM
13 renal cell carcinoma, nonpapillary 29.5 KRT7 MUC1 VIM
14 clear cell hidradenoma 12.3
15 vulvar nodular hidradenoma 12.1
16 eccrine acrospiroma 12.0
17 acrospiroma 11.4
18 breast mucoepidermoid carcinoma 10.2 MAML2 MUC1
19 apocrine adenoma 10.2 MUC1 PIK3CA
20 aggressive digital papillary adenocarcinoma 10.2 MUC1 PIK3CA
21 rare adenocarcinoma of the breast 10.2 AKT1 PIK3CA
22 anal squamous cell carcinoma 10.2 AKT1 PIK3CA
23 malignant peritoneal mesothelioma 10.1 MUC1 VIM
24 papillary tumor of the pineal region 10.1 MUC1 VIM
25 ossifying fibromyxoid tumor 10.1 MUC1 VIM
26 fibrous meningioma 10.1 MUC1 VIM
27 chordoid meningioma 10.1 MUC1 VIM
28 clear cell ependymoma 10.1 MUC1 VIM
29 eccrine porocarcinoma 10.1 MUC1 VIM
30 endometrial mucinous adenocarcinoma 10.1 MUC1 VIM
31 biphasic synovial sarcoma 10.1 MUC1 VIM
32 adenofibroma 10.1 MUC1 VIM
33 clear cell meningioma 10.1 MUC1 VIM
34 cutaneous mucoepidermoid carcinoma 10.1 KRT7 MAML2
35 myxopapillary ependymoma 10.1 MUC1 VIM
36 melanotic neuroectodermal tumor 10.1 MUC1 VIM
37 pleomorphic liposarcoma 10.1 MUC1 VIM
38 desmoplastic small round cell tumor 10.1 MUC1 VIM
39 perivascular epithelioid cell tumor 10.1 MUC1 VIM
40 anaplastic ependymoma 10.1 MUC1 VIM
41 reticulum cell sarcoma 10.1 MUC1 VIM
42 brachydactyly, type e1 10.1 AKT1 MUC1
43 malignant spiradenoma 10.1 KRT7 PIK3CA
44 sertoli cell tumor 10.1 MUC1 VIM
45 mesenchymal chondrosarcoma 10.1 MUC1 VIM
46 extraskeletal ewing sarcoma 10.1 MUC1 VIM
47 perineurioma 10.1 MUC1 VIM
48 warthin tumor 10.1 KRT7 MAML2
49 chondroid chordoma 10.1 MUC1 VIM
50 solid adenocarcinoma with mucin production 10.1 KRT7 MUC1

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to Hidradenoma

Symptoms & Phenotypes for Hidradenoma

GenomeRNAi Phenotypes related to Hidradenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.92 AKT1 MUC1 PIK3CA VIM

Drugs & Therapeutics for Hidradenoma

Search Clinical Trials , NIH Clinical Center for Hidradenoma

Cochrane evidence based reviews: adenoma, sweat gland

Genetic Tests for Hidradenoma

Anatomical Context for Hidradenoma

MalaCards organs/tissues related to Hidradenoma:

41
Skin, Breast, Salivary Gland, Lung, Kidney, Pancreas, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Hidradenoma:

19
An Apical Sweat Gl

Publications for Hidradenoma

Articles related to Hidradenoma:

(show top 50) (show all 332)
# Title Authors Year
1
Ectopic hidradenoma papilliferum of eyelid: A rare entity with diagnostic challenge. ( 29676381 )
2018
2
A Nodular Hidradenoma of Atypical Location in Pregnancy. ( 29856466 )
2018
3
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. ( 29166328 )
2018
4
Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging. ( 29388236 )
2018
5
Poroid hidradenoma in the hand: A case report and systematic review. ( 29781229 )
2018
6
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. ( 29924021 )
2018
7
Erratum: Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 29898286 )
2018
8
Malignant Transformation of Nodular Hidradenoma in the Lower Leg. ( 29928207 )
2018
9
Ectopic hidradenoma papilliferum. ( 29924236 )
2018
10
Hidradenoma papilliferum: an unusual benign perianal tumour. ( 30061121 )
2018
11
Mucinous hidradenoma in a child-A case report and review of the literature. ( 28429507 )
2017
12
A Large Lumbar Adnexal Neoplasm Presenting Characteristics of Eccrine Poroma and Poroid Hidradenoma. ( 29057137 )
2017
13
Poroid Hidradenoma: An Uncommon Cutaneous Adnexal Neoplasm. ( 28216741 )
2017
14
Sonographic Characteristics of Apocrine Nodular Hidradenoma of the Skin. ( 28880402 )
2017
15
Hidradenoma of the Chin. ( 28570408 )
2017
16
Clear cell hidradenoma of the breast with MAML2 gene rearrangement. ( 27914681 )
2017
17
A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance. ( 29079171 )
2017
18
Nodular hidradenoma: Dermoscopic presentation. ( 28087028 )
2017
19
Hidradenoma papilliferum of the vulva in a postpartum woman: A case report. ( 28287283 )
2017
20
Malignant Clear Cell Hidradenoma of the Breast. ( 28409065 )
2017
21
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. ( 28648934 )
2017
22
Large Eccrine Acrospiroma of the Hand. ( 28892973 )
2017
23
A case of cutaneous metastatic lung cancer difficult to distinguish from malignant nodular hidradenoma. ( 28664659 )
2017
24
Ultrasound Diagnosis of Nodular Hidradenoma. ( 29183622 )
2017
25
Case of chondroid syringoma mimicking as nodular hidradenoma: A diagnostic pitfall on cytopathology. ( 28772003 )
2017
26
The utility of using immunohistochemistry in the differentiation of metastatic, cutaneous clear cell renal cell carcinoma and clear cell hidradenoma. ( 28374447 )
2017
27
Nodular hidradenoma arising on the site of a BCG scar. ( 27523405 )
2017
28
Rare Adnexal Tumor of the Breast: Poroid Hidradenoma. ( 27943519 )
2017
29
Hidradenoma Papilliferum With Oncocytic Metaplasia: A Histopathological and Immunohistochemical Study. ( 27097337 )
2016
30
Lymph Node Involvement by a Clear Cell Nodular Hidradenoma-Like Tumor of Uncertain Malignant Potential. ( 28033155 )
2016
31
Ultrasonographic diagnosis of nodular hidradenoma. ( 26662046 )
2016
32
Hidradenoma masquerading digital ganglion cyst: A rare phenomenon. ( 27625783 )
2016
33
A reddish nodule with viscous fluid secretion. Solida89cystic hidradenoma (SCH). ( 26266940 )
2016
34
LYMPH NODE LOCATION OF A CLEAR CELL HIDRADENOMA: REPORT OF A PATIENT AND REVIEW OF LITERATURE. ( 27080562 )
2016
35
Hidradenoma Papilliferum: A Clinicopathologic Study of 264 Tumors From 261 Patients, With Emphasis on Mammary-Type Alterations. ( 26863059 )
2016
36
Giant metastasizing malignant hidradenoma in a child. ( 27730041 )
2016
37
A case of nodular hidradenoma of the auricle mimicking squamous cell carcinoma. ( 27350422 )
2016
38
Hidradenoma Papilliferum: A Case Report of an Uncommon Perianal Lesion. ( 26874122 )
2016
39
Vulvar hidradenoma papilliferum (HP) is located on the sites of mammary-like anogenital glands (MLAGs): Analysis of the photographs of 52 tumors. ( 26944596 )
2016
40
A Weeping Tumor in a Young Girl: An Unusual Presentation of Nodular Hidradenoma. ( 27293255 )
2016
41
A Rare Case of Cutaneous Oncocytic Hidradenoma. ( 28035705 )
2016
42
Frequent PIK3CA Activating Mutations in Hidradenoma Papilliferums. ( 27184479 )
2016
43
Ultrasound Image of Poroid Hidradenoma. ( 26762692 )
2016
44
Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up. ( 27010690 )
2016
45
Dermoscopy of Nodular Hidradenoma, a Great Masquerader: A Morphological Study of 28 Cases. ( 26606241 )
2016
46
PIK3CA and AKT1 mutations in hidradenoma papilliferum. ( 27742746 )
2016
47
Tubulopapillary Hidradenoma-like Tumour of the Mandible: A Case Report and Literature Review. ( 27943162 )
2016
48
Mutations of cancer-related genes in benign tumors: the example of hidradenoma papilliferum. ( 27865794 )
2016
49
Cutaneous hidradenoma: a study of 21 neoplasms revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions. ( 27402217 )
2016
50
Hidradenoma of the Breast: A Source of Diagnostic Confusion. ( 26391316 )
2015

Variations for Hidradenoma

Expression for Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for Hidradenoma

Pathways related to Hidradenoma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 AKT1 MUC1 PIK3CA
2 12.28 KRT7 MUC1 VIM
3
Show member pathways
12.17 AKT1 PIK3CA VIM
4 11.91 AKT1 PIK3CA VIM
5 11.35 AKT1 PIK3CA
6 11.33 AKT1 PIK3CA
7 11.29 AKT1 PIK3CA
8 11.29 AKT1 PIK3CA
9 11.27 AKT1 PIK3CA
10 11.24 AKT1 PIK3CA
11 11.22 AKT1 PIK3CA
12 11.11 AKT1 PIK3CA
13 11.09 AKT1 PIK3CA
14 11.06 AKT1 PIK3CA
15 11.04 AKT1 PIK3CA
16 11.01 AKT1 PIK3CA
17
Show member pathways
11 AKT1 PIK3CA
18 10.97 AKT1 PIK3CA
19 10.94 AKT1 PIK3CA
20 10.89 AKT1 PIK3CA
21 10.87 AKT1 PIK3CA
22 10.86 AKT1 MUC1 VIM
23 10.78 AKT1 PIK3CA
24 10.73 AKT1 PIK3CA
25 10.68 AKT1 PIK3CA
26 10.54 AKT1 PIK3CA
27 10.41 AKT1 PIK3CA
28 10.21 AKT1 VIM

GO Terms for Hidradenoma

Biological processes related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermal growth factor receptor signaling pathway GO:0007173 9.37 AKT1 PIK3CA
2 protein kinase B signaling GO:0043491 9.32 AKT1 PIK3CA
3 phosphatidylinositol 3-kinase signaling GO:0014065 9.26 AKT1 PIK3CA
4 negative regulation of macroautophagy GO:0016242 9.16 AKT1 PIK3CA
5 anoikis GO:0043276 8.96 AKT1 PIK3CA
6 cytokine-mediated signaling pathway GO:0019221 8.92 AKT1 MUC1 PIK3CA VIM

Sources for Hidradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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