MCID: HDR004
MIFTS: 37

Hidradenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Hidradenoma

MalaCards integrated aliases for Hidradenoma:

Name: Hidradenoma 12 54 15
Adenoma, Sweat Gland 44 70
Benign Neoplasm of Sweat Gland 70
Hidradenoma of Skin 12
Sweat Gland Adenoma 12
Eccrine Acrospiroma 70
Syringoadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3896
MeSH 44 D006607
NCIt 50 C7560
SNOMED-CT 67 81393009
UMLS 70 C0019522 C0206671 C0684354

Summaries for Hidradenoma

Disease Ontology : 12 A sweat gland benign neoplasm that is located in an apical sweat gland.

MalaCards based summary : Hidradenoma, also known as adenoma, sweat gland, is related to syringocystadenoma papilliferum and nodular hidradenoma. An important gene associated with Hidradenoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Interleukin-4 and 13 signaling. Affiliated tissues include an apical sweat gland, breast and skin.

Wikipedia : 73 Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. These are 1-3 cm translucent... more...

Related Diseases for Hidradenoma

Diseases related to Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 31.9 PIP MUC1
2 nodular hidradenoma 31.4 VIM PIP MUC1 EMC7 CEACAM5
3 eccrine acrospiroma 30.7 PIP MAML2 KRT7 KRT5 KRT15 EMC7
4 clear cell hidradenoma 30.7 PIP MME MAML2 KRT7 KRT5 CRTC3
5 adenoma 30.5 PIK3CA MUC1 KRT7 AKT1
6 malignant acrospiroma 30.4 PIP PHLDA1 MAML2 KRT7 KRT5 CEACAM5
7 mammary paget's disease 30.3 PIP MUC1 KRT7
8 syringoma 30.2 VIM MUC1 KRT7 CEACAM5
9 ceruminoma 30.0 PIP KRT7 KRT5
10 spiradenoma 29.9 VIM MUC1 KRT7 KRT15
11 benign breast phyllodes tumor 29.9 VIM MME
12 cystadenoma 29.9 MUC1 MME KRT7 CEACAM5
13 subareolar duct papillomatosis 29.8 MME KRT7 KRT5
14 benign teratoma 29.8 MUC1 KRT7 CEACAM5
15 in situ carcinoma 29.7 PIP PIK3CA MUC1 KRT5 AKT1
16 breast ductal carcinoma 29.7 PIP MUC1 KRT7 KRT5
17 skin benign neoplasm 29.7 PIP KRT7 KRT5
18 rectum adenocarcinoma 29.6 PIP PIK3CA KRT7 CEACAM5
19 vulva cancer 29.6 PIP PIK3CA KRT7 CEACAM5
20 papillary adenocarcinoma 29.5 VIM PIP MUC1 KRT7 CEACAM5
21 papillary adenoma 29.5 VIM KRT7 KRT5 CEACAM5
22 squamous cell carcinoma 29.4 PIK3CA MUC1 KRT7 CEACAM5 AKT1
23 mucoepidermoid carcinoma 29.4 MUC1 MAML2 KRT7 KRT5 CRTC3 CRTC1
24 renal cell carcinoma, nonpapillary 29.3 VIM PIK3CA MUC1 MME KRT7 AKT1
25 clear cell renal cell carcinoma 29.2 VIM MUC1 MME KRT7 AKT1
26 ductal carcinoma in situ 29.2 PIP PIK3CA MUC1 MME KRT5 AKT1
27 paget disease, extramammary 29.2 PIP MUC1 KRT7 KRT5 CEACAM5
28 hidrocystoma 29.1 PIP PHLDA1 KRT7 KRT15 CEACAM5
29 eccrine papillary adenoma 29.0 PIP PIK3CA KRT7 KRT5 KRT15 CEACAM5
30 sweat gland cancer 29.0 PIP KRT7 KRT5 KRT15 CEACAM5
31 keratosis, seborrheic 29.0 PIK3CA KRT7 KRT5 EMC7 CEACAM5
32 adenosquamous carcinoma 28.9 PIK3CA MUC1 MAML2 KRT7 KRT5 CRTC1
33 basal cell carcinoma 28.6 PHLDA1 MME KRT7 KRT5 KRT15 CEACAM5
34 papillary hidradenoma 11.5
35 vulvar nodular hidradenoma 11.1
36 lacrimal gland mucoepidermoid carcinoma 10.4 MAML2 CRTC1
37 schneiderian carcinoma 10.4 MAML2 CRTC1
38 squamous cell papilloma 10.4
39 papilloma 10.4
40 breast juvenile papillomatosis 10.4 PIK3CA AKT1
41 cervical adenosquamous carcinoma 10.3 MAML2 CRTC1
42 rare tumor 10.3
43 papillary tumor of the pineal region 10.3 VIM MUC1
44 meningioma, radiation-induced 10.3 PIK3CA AKT1
45 endometrial mucinous adenocarcinoma 10.3 VIM MUC1
46 anus basaloid carcinoma 10.3 PIK3CA KRT7
47 nephrogenic adenoma 10.3 MUC1 KRT7
48 cutaneous leiomyosarcoma 10.3 VIM MUC1
49 scrotum paget's disease 10.3 MUC1 KRT7
50 gallbladder signet ring cell adenocarcinoma 10.3 MUC1 KRT7

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to Hidradenoma

Symptoms & Phenotypes for Hidradenoma

Drugs & Therapeutics for Hidradenoma

Search Clinical Trials , NIH Clinical Center for Hidradenoma

Cochrane evidence based reviews: adenoma, sweat gland

Genetic Tests for Hidradenoma

Anatomical Context for Hidradenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Hidradenoma:

19
An Apical Sweat Gland

MalaCards organs/tissues related to Hidradenoma:

40
Breast, Skin, Lung, Liver, Salivary Gland, Thymus, Kidney

Publications for Hidradenoma

Articles related to Hidradenoma:

(show top 50) (show all 582)
# Title Authors PMID Year
1
Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). 61 54
17551948 2007
2
Immunohistochemistry in the differential diagnosis of nodular hidradenoma and glomus tumor. 54 61
1380207 1992
3
MYB Translocations in Both Myoepithelial and Ductoglandular Epithelial Cells in Adenoid Cystic Carcinoma: A Histopathologic and Genetic Reappraisal in Six Primary Cutaneous Cases. 61
32732690 2021
4
NUT Is a Specific Immunohistochemical Marker for the Diagnosis of YAP1-NUTM1-rearranged Cutaneous Poroid Neoplasms. 61
33739783 2021
5
Clear Cell Hidradenoma-Basal Cell Carcinoma Collision. 61
32804693 2021
6
Hidradeonoma Papilliferum of the Anus: A Case Report About the Relationship Between Neoplasms of the Mammary-Like-Glands and Hormones. 61
33680603 2021
7
Eccrine Hidradenoma of the Nasal Vestibule: A Rare Clinical Entity. 61
33587647 2021
8
Hidradenocarcinoma: a rare but challenging diagnosis. 61
33549922 2021
9
Three Cases of Clear Cell Hidradenoma With "Benign" Lymph Node Involvement. 61
33464750 2021
10
Androgen receptor expression in epidermal and adnexal tumours. 61
33478823 2021
11
An unusual presentation of a nodular hidradenoma: A case report and review of the literature. 61
33384876 2021
12
Low-Grade Mucoepidermoid Carcinoma Versus Nodular Hidradenoma: Potential Diagnostic Challenge in Breast Pathology. 61
33325313 2020
13
Apocrine (Nodular) Hidradenoma and Adenomyoepithelioma Most Likely Do Not Form a Biological Continuum of Adnexal Neoplasia. 61
33395047 2020
14
Vulval hidradenoma papilliferum: a clinical and dermoscopic study. 61
32356582 2020
15
Does a Biological Continuum Between Nodular (Apocrine) Hidradenoma and Adenomyoepithelioma Really Exist? 61
32271207 2020
16
Poroid hidradenoma: a benign lesion masking as a malignant breast tumor. 61
32240315 2020
17
Clear cell papillary neoplasm of the breast with MAML2 gene rearrangement: Clear cell hidradenoma or low-grade mucoepidermoid carcinoma? 61
32853960 2020
18
Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings. 61
32362207 2020
19
Perineal Clear Cell Hidradenoma: A GATA3-positive Neoplasm With Potential for Misdiagnosis. 61
32925441 2020
20
Rapidly Enlarging Hidradenoma of the Eyelid. 61
32976334 2020
21
Clear Cell Hidradenoma of the Breast Diagnosed on a Core Needle Biopsy: A case report and review of the literature. 61
33110653 2020
22
Apocrine Hidradenoma and Adenomyoepithelioma: Entities on a Biological Continuum of Adnexal Neoplasia. 61
31977321 2020
23
Clinicopathologic Characterization of Hidradenoma on Acral Sites: A Diagnostic Pitfall With Digital Papillary Adenocarcinoma. 61
31876586 2020
24
Hidradenoma Papilliferum: Everyone Else's Diagnosis. 61
32180606 2020
25
Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions. 61
32190505 2020
26
Hidradenoma papilliferum of the external auditory canal. Case report. 61
31871682 2020
27
Clear cell hidradenoma of the hand: A case report in an 83-year old patient. 61
32979831 2020
28
Tubulopapillary hidradenoma-like tumor of the mandible: Two case reports of an underrecognized entity. 61
31630920 2020
29
Hidradenoma Papilliferum of the Anus: A Report of 2 Cases and Review of the Literature. 61
31937076 2019
30
Malignant sweat gland tumor of breast arising in pre-existing benign tumor: A case report. 61
31624751 2019
31
Solid-Cystic Hidradenoma: A Dorsal Foot Presentation. 61
31599665 2019
32
[Anal and vulvar hidradenoma papilliferum are similar: A study of 14 cases]. 61
31196616 2019
33
[Anatomoclinical and immunohistochemical study of hidradenoma papilliferum, a tumor deriving from anogenital mammary-like glands]. 61
31285043 2019
34
Pilar Cyst Pigmented Epithelial Remnants: A Potential Diagnostic Pitfall. 61
31039667 2019
35
Case Report and Literature Review of Nodular Hiradenoma, a Rare Adnexal Tumor That Mimics Breast Carcinoma, in a 20-Year-Old Woman. 61
30722042 2019
36
Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network. 61
31010589 2019
37
Poroid hidradenoma of the scalp in an immunosuppressed patient. 61
31086655 2019
38
Ischiorectal fossa: benign and malignant neoplasms of this "ignored" radiological anatomical space. 61
30955068 2019
39
"Hidradenoma of the breast: Magnetic resonance (MR) imaging and ultrasonography (US) findings of this rare mass". 61
30761677 2019
40
Perianal nodule in a young woman. 61
29851125 2019
41
Dermatoscopy: an auxiliary resource for the diagnosis of poroid neoplasms. 61
30484540 2018
42
Dermatoscopy: an auxiliary resource for the diagnosis of poroid neoplasms. 61
33261770 2018
43
Cyto-Histopathological Correlation of Skin Adnexal Tumors: A Short Series. 61
30498290 2018
44
A Nodular Hidradenoma of Atypical Location in Pregnancy. 61
29856466 2018
45
Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging. 61
29388236 2018
46
Hidradenoma papilliferum: an unusual benign perianal tumour. 61
30061121 2018
47
Erratum: Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. 61
29898286 2018
48
Ultrasound Diagnosis of Nodular Hidradenoma. 61
29183622 2018
49
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. 61
29924021 2018
50
Ectopic hidradenoma papilliferum. 61
29924236 2018

Variations for Hidradenoma

Expression for Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for Hidradenoma

Pathways related to Hidradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 VIM MUC1 KRT7 KRT5
2 11.55 VIM MUC1 AKT1
3
Show member pathways
11.47 VIM KRT7 KRT5
4 11.26 PIK3CA CRTC3 CRTC1 AKT1
5 11 VIM MME AKT1
6 10.71 PIK3CA AKT1
7 10.66 VIM AKT1
8 10.62 PIK3CA AKT1

GO Terms for Hidradenoma

Cellular components related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 CEACAM5 KRT15 KRT5 KRT7 MME MUC1
2 intermediate filament GO:0005882 8.92 KRT15 KRT5 KRT7 VIM

Biological processes related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.5 KRT15 KRT5 KRT7
2 cytokine-mediated signaling pathway GO:0019221 9.46 AKT1 MUC1 PIK3CA VIM
3 negative regulation of anoikis GO:2000811 9.37 PIK3CA CEACAM5
4 negative regulation of macroautophagy GO:0016242 9.26 AKT1 PIK3CA
5 anoikis GO:0043276 8.96 AKT1 PIK3CA
6 energy homeostasis GO:0097009 8.8 CRTC1 CRTC3 PIK3CA

Molecular functions related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.33 KRT15 KRT5 VIM
2 cAMP response element binding protein binding GO:0008140 8.96 CRTC3 CRTC1
3 scaffold protein binding GO:0097110 8.8 VIM KRT5 KRT15

Sources for Hidradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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