MCID: HDR004
MIFTS: 37

Hidradenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Hidradenoma

MalaCards integrated aliases for Hidradenoma:

Name: Hidradenoma 12 54 15
Adenoma, Sweat Gland 43 71
Benign Neoplasm of Sweat Gland 71
Hidradenoma of Skin 12
Sweat Gland Adenoma 12
Eccrine Acrospiroma 71
Syringoadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3896
MeSH 43 D006607
NCIt 49 C7560
SNOMED-CT 67 81393009
UMLS 71 C0019522 C0206671 C0684354

Summaries for Hidradenoma

Disease Ontology : 12 A sweat gland benign neoplasm that is located in an apical sweat gland.

MalaCards based summary : Hidradenoma, also known as adenoma, sweat gland, is related to syringocystadenoma papilliferum and nodular hidradenoma. An important gene associated with Hidradenoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Interleukin-4 and 13 signaling. Affiliated tissues include an apical sweat gland, skin and breast.

Wikipedia : 74 Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. These are 1-3 cm translucent... more...

Related Diseases for Hidradenoma

Diseases related to Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 32.9 PIP MUC1
2 nodular hidradenoma 32.8 VIM PIP MUC1 KRT7 CLEC2A CEACAM5
3 malignant acrospiroma 31.8 MAML2 KRT7 KRT5 CLEC2A CEACAM5
4 eccrine acrospiroma 31.7 PIP MAML2 KRT7 KRT5 KRT15 CLEC2A
5 clear cell hidradenoma 31.6 PIP MME MAML2 KRT7 KRT5 CRTC3
6 apocrine adenoma 30.8 PIP KRT7
7 eccrine papillary adenoma 30.7 PIP CEACAM5
8 mammary paget's disease 30.6 PIP MUC1 KRT7
9 myoepithelioma 30.2 ZNF444 VIM MUC1
10 spindle cell sarcoma 30.2 VIM MUC1 KRT7
11 ceruminoma 30.2 PIP KRT7 KRT5
12 subareolar duct papillomatosis 30.2 MME KRT7 KRT5
13 keratosis 30.1 PIK3CA KRT5 CEACAM5
14 adenocarcinoma 30.1 PIK3CA MUC1 KRT7 CEACAM5 AKT1
15 syringoma 30.1 VIM MUC1 KRT7 CLEC2A CEACAM5
16 breast ductal carcinoma 30.0 PIP MUC1 KRT7 KRT5
17 cystadenoma 30.0 MUC1 MME KRT7 CEACAM5
18 benign breast phyllodes tumor 29.9 VIM MME
19 in situ carcinoma 29.9 PIP PIK3CA MUC1 KRT5 AKT1
20 rectum adenocarcinoma 29.8 PIP PIK3CA KRT7 CEACAM5
21 vulva cancer 29.8 PIP PIK3CA KRT7 CEACAM5
22 squamous cell carcinoma 29.8 PIK3CA MUC1 KRT7 CEACAM5 AKT1
23 benign teratoma 29.7 MUC1 KRT7 CLEC2A CEACAM5
24 papillary adenocarcinoma 29.7 VIM PIP MUC1 KRT7 CEACAM5
25 papillary adenoma 29.6 VIM KRT7 KRT5 CEACAM5
26 skin benign neoplasm 29.6 PIP KRT7 KRT5 CLEC2A
27 spiradenoma 29.6 VIM MUC1 KRT7 KRT15 CLEC2A
28 hidrocystoma 29.3 PIP KRT7 KRT15 CLEC2A CEACAM5
29 mucoepidermoid carcinoma 29.3 MUC1 MAML2 KRT7 KRT5 CRTC3 CRTC1
30 keratosis, seborrheic 29.3 PIK3CA KRT7 KRT5 CLEC2A CEACAM5
31 paget disease, extramammary 29.2 PIP MUC1 KRT7 KRT5 CEACAM5
32 renal cell carcinoma, nonpapillary 29.2 VIM PIK3CA MUC1 MME KRT7 AKT1
33 ductal carcinoma in situ 29.2 PIP PIK3CA MUC1 MME KRT5 AKT1
34 adenoid cystic carcinoma 29.2 VIM PIK3CA MUC1 KRT7 KRT5 AKT1
35 basal cell carcinoma 28.9 MME KRT7 KRT5 KRT15 CEACAM5
36 adenosquamous carcinoma 28.8 PIK3CA MUC1 MAML2 KRT7 KRT5 CRTC1
37 clear cell renal cell carcinoma 28.6 VIM MUC1 MME KRT7
38 sweat gland cancer 28.5 PIP KRT7 KRT5 KRT15 CLEC2A CEACAM5
39 sweat gland benign neoplasm 27.9 ZNF444 PIP MME MAML2 KRT7 KRT5
40 papillary hidradenoma 12.7
41 vulvar nodular hidradenoma 12.2
42 lacrimal gland mucoepidermoid carcinoma 10.6 MAML2 CRTC1
43 schneiderian carcinoma 10.6 MAML2 CRTC1
44 breast mucoepidermoid carcinoma 10.5 MAML2 CRTC1
45 squamous cell papilloma 10.5
46 papilloma 10.5
47 aggressive digital papillary adenocarcinoma 10.5 MUC1 MAML2
48 adenoma 10.5
49 rare tumor 10.5
50 breast juvenile papillomatosis 10.5 PIK3CA AKT1

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to Hidradenoma

Symptoms & Phenotypes for Hidradenoma

Drugs & Therapeutics for Hidradenoma

Search Clinical Trials , NIH Clinical Center for Hidradenoma

Cochrane evidence based reviews: adenoma, sweat gland

Genetic Tests for Hidradenoma

Anatomical Context for Hidradenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Hidradenoma:

19
An Apical Sweat Gland

MalaCards organs/tissues related to Hidradenoma:

40
Skin, Breast, Lymph Node, Salivary Gland, Smooth Muscle, Thyroid, Eye

Publications for Hidradenoma

Articles related to Hidradenoma:

(show top 50) (show all 563)
# Title Authors PMID Year
1
Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). 54 61
17551948 2007
2
Immunohistochemistry in the differential diagnosis of nodular hidradenoma and glomus tumor. 61 54
1380207 1992
3
Clinicopathologic Characterization of Hidradenoma on Acral Sites: A Diagnostic Pitfall With Digital Papillary Adenocarcinoma. 61
31876586 2020
4
Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings. 61
32362207 2020
5
Vulvar hidradenoma papilliferum. A clinical and dermoscopic study in a case series. 61
32356582 2020
6
Does a Biological Continuum Between Nodular (Apocrine) Hidradenoma and Adenomyoepithelioma Really Exist? 61
32271207 2020
7
Poroid Hidradenoma; a Benign Lesion Masking as Malignant Breast Tumor. 61
32240315 2020
8
Hidradenoma Papilliferum: Everyone Else's Diagnosis. 61
32180606 2020
9
Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions. 61
32190505 2020
10
Hidradenoma papilliferum of the external auditory canal. Case report. 61
31871682 2020
11
Apocrine Hidradenoma and Adenomyoepithelioma: Entities on a Biological Continuum of Adnexal Neoplasia. 61
31977321 2020
12
Tubulopapillary hidradenoma-like tumor of the mandible: Two case reports of an underrecognized entity. 61
31630920 2020
13
Hidradenoma Papilliferum of the Anus: A Report of 2 Cases and Review of the Literature. 61
31937076 2019
14
Malignant sweat gland tumor of breast arising in pre-existing benign tumor: A case report. 61
31624751 2019
15
[Anal and vulvar hidradenoma papilliferum are similar: A study of 14 cases]. 61
31196616 2019
16
Solid-Cystic Hidradenoma: A Dorsal Foot Presentation. 61
31599665 2019
17
Pilar Cyst Pigmented Epithelial Remnants: A Potential Diagnostic Pitfall. 61
31039667 2019
18
[Anatomoclinical and immunohistochemical study of hidradenoma papilliferum, a tumor deriving from anogenital mammary-like glands]. 61
31285043 2019
19
Case Report and Literature Review of Nodular Hiradenoma, a Rare Adnexal Tumor That Mimics Breast Carcinoma, in a 20-Year-Old Woman. 61
30722042 2019
20
Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network. 61
31010589 2019
21
Poroid hidradenoma of the scalp in an immunosuppressed patient. 61
31086655 2019
22
Ischiorectal fossa: benign and malignant neoplasms of this "ignored" radiological anatomical space. 61
30955068 2019
23
"Hidradenoma of the breast: Magnetic resonance (MR) imaging and ultrasonography (US) findings of this rare mass". 61
30761677 2019
24
Perianal nodule in a young woman. 61
29851125 2019
25
Dermatoscopy: an auxiliary resource for the diagnosis of poroid neoplasms. 61
30484540 2018
26
Cyto-Histopathological Correlation of Skin Adnexal Tumors: A Short Series. 61
30498290 2018
27
A Nodular Hidradenoma of Atypical Location in Pregnancy. 61
29856466 2018
28
Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging. 61
29388236 2018
29
Hidradenoma papilliferum: an unusual benign perianal tumour. 61
30061121 2018
30
Erratum: Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. 61
29898286 2018
31
Ultrasound Diagnosis of Nodular Hidradenoma. 61
29183622 2018
32
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. 61
29924021 2018
33
Ectopic hidradenoma papilliferum. 61
29924236 2018
34
Malignant Transformation of Nodular Hidradenoma in the Lower Leg. 61
29928207 2018
35
Poroid hidradenoma in the hand: A case report and systematic review. 61
29781229 2018
36
Ectopic hidradenoma papilliferum of eyelid: A rare entity with diagnostic challenge. 61
29676381 2018
37
BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin. 61
29241739 2018
38
Sonographic Characteristics of Apocrine Nodular Hidradenoma of the Skin. 61
28880402 2018
39
A case of cutaneous metastatic lung cancer difficult to distinguish from malignant nodular hidradenoma. 61
28664659 2018
40
Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. 61
28772003 2018
41
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. 61
29166328 2018
42
A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance. 61
29079171 2017
43
Lymph Node Involvement by a Clear Cell Nodular Hidradenoma-Like Tumor of Uncertain Malignant Potential. 61
28033155 2017
44
[Nodular hidradenoma]. 61
27993543 2017
45
Tubulopapillary Hidradenoma-like Tumour of the Mandible: A Case Report and Literature Review. 61
27943162 2017
46
[Hidradenocarcinoma of the heel associated with inguinal metastases]. 61
28528731 2017
47
Nodular hidradenoma arising on the site of a BCG scar. 61
27523405 2017
48
Pigmented Trichoblastoma of Nose: An Unusual Occurrence. 61
28892945 2017
49
The utility of using immunohistochemistry in the differentiation of metastatic, cutaneous clear cell renal cell carcinoma and clear cell hidradenoma. 61
28374447 2017
50
Hidradenoma of the Chin. 61
28570408 2017

Variations for Hidradenoma

Expression for Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for Hidradenoma

Pathways related to Hidradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 VIM MUC1 KRT7 KRT5
2 11.55 VIM MUC1 AKT1
3
Show member pathways
11.47 VIM KRT7 KRT5
4 11.26 PIK3CA CRTC3 CRTC1 AKT1
5 11 VIM MME AKT1
6 10.66 VIM AKT1
7 10.62 PIK3CA AKT1

GO Terms for Hidradenoma

Cellular components related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 VIM PIP MUC1 MME KRT7 KRT5
2 intermediate filament GO:0005882 8.92 VIM KRT7 KRT5 KRT15

Biological processes related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.5 KRT7 KRT5 KRT15
2 cytokine-mediated signaling pathway GO:0019221 9.46 VIM PIK3CA MUC1 AKT1
3 negative regulation of anoikis GO:2000811 9.37 PIK3CA CEACAM5
4 negative regulation of macroautophagy GO:0016242 9.26 PIK3CA AKT1
5 anoikis GO:0043276 8.96 PIK3CA AKT1
6 energy homeostasis GO:0097009 8.8 PIK3CA CRTC3 CRTC1

Molecular functions related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.33 VIM KRT5 KRT15
2 cAMP response element binding protein binding GO:0008140 8.96 CRTC3 CRTC1
3 scaffold protein binding GO:0097110 8.8 VIM KRT5 KRT15

Sources for Hidradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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