MCID: HDR004
MIFTS: 38

Hidradenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Hidradenoma

MalaCards integrated aliases for Hidradenoma:

Name: Hidradenoma 12 55 15
Adenoma, Sweat Gland 44 72
Benign Neoplasm of Sweat Gland 72
Hidradenoma of Skin 12
Sweat Gland Adenoma 12
Eccrine Acrospiroma 72
Syringoadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3896
MeSH 44 D006607
NCIt 50 C7563
SNOMED-CT 68 81393009
UMLS 72 C0019522 C0206671 C0684354

Summaries for Hidradenoma

Disease Ontology : 12 A sweat gland neoplasm that is located in an apical sweat gland.

MalaCards based summary : Hidradenoma, also known as adenoma, sweat gland, is related to nodular hidradenoma and hidradenocarcinoma. An important gene associated with Hidradenoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Interleukin-4 and 13 signaling. Affiliated tissues include skin, breast and salivary gland, and related phenotype is Decreased cell migration.

Wikipedia : 75 Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. These are 1-3 cm translucent... more...

Related Diseases for Hidradenoma

Diseases related to Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 nodular hidradenoma 33.7 VIM MUC1 KRT7
2 hidradenocarcinoma 33.1 VIM KRT7 KRT5
3 syringocystadenoma papilliferum 33.1 VIM MUC1
4 syringoma 31.4 VIM MUC1
5 apocrine adenoma 31.2 PIK3CA MUC1
6 spiradenoma 31.0 MUC1 KRT7
7 cystadenoma 31.0 MUC1 KRT7
8 mammary paget's disease 30.6 MUC1 KRT7
9 mucoepidermoid carcinoma 30.6 MUC1 MAML2 KRT7
10 ceruminoma 30.5 KRT7 KRT5
11 hidrocystoma 30.5 KRT7 KRT15
12 paget disease, extramammary 30.4 MUC1 KRT7
13 papillary adenoma 30.4 VIM KRT7
14 ductal carcinoma in situ 30.2 MUC1 KRT5 AKT1
15 spindle cell sarcoma 30.1 VIM MUC1 KRT7
16 dermoid cyst 30.0 VIM MUC1 KRT7
17 papillary adenocarcinoma 30.0 VIM MUC1 KRT7
18 keratosis, seborrheic 29.9 PIK3CA KRT5
19 clear cell renal cell carcinoma 29.9 VIM MUC1 KRT7
20 sweat gland cancer 29.4 KRT7 KRT5 KRT15
21 adenosquamous carcinoma 29.4 PIK3CA MUC1 KRT7 KRT5
22 adenoid cystic carcinoma 28.4 VIM PIK3CA MUC1 KRT7 KRT5 AKT1
23 papillary hidradenoma 12.7
24 clear cell hidradenoma 12.4
25 vulvar nodular hidradenoma 12.2
26 eccrine acrospiroma 12.2
27 acrospiroma 11.5
28 breast mucoepidermoid carcinoma 10.6 MUC1 MAML2
29 aggressive digital papillary adenocarcinoma 10.6 PIK3CA MUC1
30 rare adenocarcinoma of the breast 10.6 PIK3CA AKT1
31 adenofibroma 10.5 VIM MUC1
32 perineurioma 10.5 VIM MUC1
33 anal squamous cell carcinoma 10.5 PIK3CA AKT1
34 malignant peritoneal mesothelioma 10.5 VIM MUC1
35 squamous cell papilloma 10.5
36 papilloma 10.5
37 papillary tumor of the pineal region 10.5 VIM MUC1
38 chordoid meningioma 10.5 VIM MUC1
39 fibrous meningioma 10.5 VIM MUC1
40 ossifying fibromyxoid tumor 10.5 VIM MUC1
41 clear cell ependymoma 10.5 VIM MUC1
42 adenoma 10.5
43 biphasic synovial sarcoma 10.5 VIM MUC1
44 endometrial mucinous adenocarcinoma 10.5 VIM MUC1
45 myxopapillary ependymoma 10.5 VIM MUC1
46 clear cell meningioma 10.5 VIM MUC1
47 desmoplastic small round cell tumor 10.5 VIM MUC1
48 pleomorphic liposarcoma 10.5 VIM MUC1
49 cutaneous mucoepidermoid carcinoma 10.5 MAML2 KRT7
50 anaplastic ependymoma 10.5 VIM MUC1

Graphical network of the top 20 diseases related to Hidradenoma:



Diseases related to Hidradenoma

Symptoms & Phenotypes for Hidradenoma

GenomeRNAi Phenotypes related to Hidradenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.92 AKT1 MUC1 PIK3CA VIM

Drugs & Therapeutics for Hidradenoma

Search Clinical Trials , NIH Clinical Center for Hidradenoma

Cochrane evidence based reviews: adenoma, sweat gland

Genetic Tests for Hidradenoma

Anatomical Context for Hidradenoma

MalaCards organs/tissues related to Hidradenoma:

41
Skin, Breast, Salivary Gland, Lymph Node, Thyroid, Smooth Muscle, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Hidradenoma:

19
An Apical Sweat Gland

Publications for Hidradenoma

Articles related to Hidradenoma:

(show top 50) (show all 550)
# Title Authors PMID Year
1
Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). 9 38
17551948 2007
2
Immunohistochemistry in the differential diagnosis of nodular hidradenoma and glomus tumor. 9 38
1380207 1992
3
[Anatomoclinical and immunohistochemical study of hidradenoma papilliferum, a tumor deriving from anogenital mammary-like glands]. 38
31285043 2019
4
Pilar Cyst Pigmented Epithelial Remnants: A Potential Diagnostic Pitfall. 38
31039667 2019
5
[Anal and vulvar hidradenoma papilliferum are similar: A study of 14 cases]. 38
31196616 2019
6
Case Report and Literature Review of Nodular Hiradenoma, a Rare Adnexal Tumor That Mimics Breast Carcinoma, in a 20-Year-Old Woman. 38
30722042 2019
7
Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network. 38
31010589 2019
8
Poroid hidradenoma of the scalp in an immunosuppressed patient. 38
31086655 2019
9
Ischiorectal fossa: benign and malignant neoplasms of this "ignored" radiological anatomical space. 38
30955068 2019
10
"Hidradenoma of the breast: Magnetic resonance (MR) imaging and ultrasonography (US) findings of this rare mass". 38
30761677 2019
11
Perianal nodule in a young woman. 38
29851125 2019
12
Dermatoscopy: an auxiliary resource for the diagnosis of poroid neoplasms. 38
30484540 2018
13
Cyto-Histopathological Correlation of Skin Adnexal Tumors: A Short Series. 38
30498290 2018
14
A Nodular Hidradenoma of Atypical Location in Pregnancy. 38
29856466 2018
15
Clear Cell Hidradenoma: Characteristic Imaging Features on Ultrasonography, Computed Tomography, and Magnetic Resonance Imaging. 38
29388236 2018
16
Hidradenoma papilliferum: an unusual benign perianal tumour. 38
30061121 2018
17
Erratum: Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. 38
29898286 2018
18
Ultrasound Diagnosis of Nodular Hidradenoma. 38
29183622 2018
19
Mammographic and ultrasound findings in poroid hidradenoma of the breast mimicking intraductal papilloma and papillary carcinoma: A case report. 38
29924021 2018
20
Ectopic hidradenoma papilliferum. 38
29924236 2018
21
Malignant Transformation of Nodular Hidradenoma in the Lower Leg. 38
29928207 2018
22
Poroid hidradenoma in the hand: A case report and systematic review. 38
29781229 2018
23
Ectopic hidradenoma papilliferum of eyelid: A rare entity with diagnostic challenge. 38
29676381 2018
24
BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin. 38
29241739 2018
25
Sonographic Characteristics of Apocrine Nodular Hidradenoma of the Skin. 38
28880402 2018
26
A case of cutaneous metastatic lung cancer difficult to distinguish from malignant nodular hidradenoma. 38
28664659 2018
27
Case of chondroid syringoma mimicking a nodular hidradenoma: A diagnostic pitfall on cytopathology. 38
28772003 2018
28
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. 38
29166328 2018
29
A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance. 38
29079171 2017
30
Lymph Node Involvement by a Clear Cell Nodular Hidradenoma-Like Tumor of Uncertain Malignant Potential. 38
28033155 2017
31
[Nodular hidradenoma]. 38
27993543 2017
32
Tubulopapillary Hidradenoma-like Tumour of the Mandible: A Case Report and Literature Review. 38
27943162 2017
33
[Hidradenocarcinoma of the heel associated with inguinal metastases]. 38
28528731 2017
34
Nodular hidradenoma arising on the site of a BCG scar. 38
27523405 2017
35
Pigmented Trichoblastoma of Nose: An Unusual Occurrence. 38
28892945 2017
36
The utility of using immunohistochemistry in the differentiation of metastatic, cutaneous clear cell renal cell carcinoma and clear cell hidradenoma. 38
28374447 2017
37
Hidradenoma papilliferum of the vulva in a postpartum woman: A case report. 38
28287283 2017
38
Mucinous hidradenoma in a child-A case report and review of the literature. 38
28429507 2017
39
Hidradenoma of the Chin. 38
28570408 2017
40
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. 38
28648934 2017
41
SOX10 immunohistochemistry in sweat ductal/glandular neoplasms. 38
28343365 2017
42
PIK3CA and AKT1 mutations in hidradenoma papilliferum. 38
27742746 2017
43
Study of Selected BRCA1, BRCA2, and PIK3CA Mutations in Benign and Malignant Lesions of Anogenital Mammary-Like Glands. 38
28291131 2017
44
Rare Adnexal Tumor of the Breast: Poroid Hidradenoma. 38
27943519 2017
45
Mutations of cancer-related genes in benign tumors: the example of hidradenoma papilliferum. 38
27865794 2017
46
Clinicopathological analysis of 384 cases of poroid neoplasms including 98 cases of apocrine type cases. 38
27177596 2017
47
Case for diagnosis. A bluish nodule on the scalp. 38
28538899 2017
48
Malignant Clear Cell Hidradenoma of the Breast. 38
28409065 2017
49
A rare case of cutaneous oncocytic hidradenoma. 38
28035705 2017
50
Nodular hidradenoma: Dermoscopic presentation. 38
28087028 2017

Variations for Hidradenoma

Expression for Hidradenoma

Search GEO for disease gene expression data for Hidradenoma.

Pathways for Hidradenoma

GO Terms for Hidradenoma

Cellular components related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 9.13 MUC1 LGR6 AKT1
2 intermediate filament GO:0005882 8.92 VIM KRT7 KRT5 KRT15

Biological processes related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.5 KRT7 KRT5 KRT15
2 protein kinase B signaling GO:0043491 9.4 PIK3CA AKT1
3 phosphatidylinositol 3-kinase signaling GO:0014065 9.37 PIK3CA AKT1
4 cornification GO:0070268 9.33 KRT7 KRT5 KRT15
5 negative regulation of macroautophagy GO:0016242 9.26 PIK3CA AKT1
6 anoikis GO:0043276 8.96 PIK3CA AKT1
7 cytokine-mediated signaling pathway GO:0019221 8.92 VIM PIK3CA MUC1 AKT1

Molecular functions related to Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 VIM KRT5 KRT15
2 scaffold protein binding GO:0097110 8.8 VIM KRT5 KRT15

Sources for Hidradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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