MCID: HGH041
MIFTS: 32

High-Grade Astrocytoma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for High-Grade Astrocytoma

MalaCards integrated aliases for High-Grade Astrocytoma:

Name: High-Grade Astrocytoma 59

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA251561

Summaries for High-Grade Astrocytoma

MalaCards based summary : High-Grade Astrocytoma is related to diffuse intrinsic pontine glioma and hydrocephalus. An important gene associated with High-Grade Astrocytoma is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways is MSP-RON Signaling. The drugs Etoposide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for High-Grade Astrocytoma

Diseases related to High-Grade Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 diffuse intrinsic pontine glioma 30.5 PARP1 ACVR1
2 hydrocephalus 29.5 TGFB2 PTEN FLNA
3 glial tumor 11.8
4 astrocytoma 11.0
5 glioblastoma 10.9
6 glioblastoma multiforme 10.9
7 grade iii astrocytoma 10.7
8 glioma 10.6
9 adult astrocytic tumour 10.4 PTEN IDH1
10 keloid formation 10.4 PTEN FLNA
11 fibrillary astrocytoma 10.3
12 malignant glioma 10.3
13 low-grade astrocytoma 10.3
14 gliomatosis cerebri 10.3 PTEN IDH1
15 brain cancer 10.2
16 brain stem glioma 10.2 IDH1 ACVR1
17 breast cancer 10.2
18 neutropenia 10.2
19 clivus chordoma 10.2 PTEN PARP1
20 retinoblastoma 10.1
21 lymphoma 10.1
22 oligodendroglioma 10.1
23 familial retinoblastoma 10.1
24 pleomorphic xanthoastrocytoma 10.1
25 brain tumor, childhood 10.1
26 pilocytic astrocytoma 10.1
27 rare surgical neurologic disease 10.1
28 acute contagious conjunctivitis 10.0 GPI ACVR1
29 multiple sclerosis 9.9
30 medulloblastoma 9.9
31 neurofibromatosis, type iv, of riccardi 9.9
32 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
33 hydrocephalus, normal-pressure 9.9
34 mismatch repair cancer syndrome 9.9
35 meningioma, radiation-induced 9.9
36 meningioma, familial 9.9
37 leukemia, chronic myeloid 9.9
38 hydrops, lactic acidosis, and sideroblastic anemia 9.9
39 exanthem 9.9
40 cysticercosis 9.9
41 spinal meningioma 9.9
42 pancytopenia 9.9
43 facial paralysis 9.9
44 phaeohyphomycosis 9.9
45 supratentorial cancer 9.9
46 central nervous system lymphoma 9.9
47 vaccinia 9.9
48 secretory meningioma 9.9
49 lymphoplasmacyte-rich meningioma 9.9
50 peripheral nervous system disease 9.9

Graphical network of the top 20 diseases related to High-Grade Astrocytoma:



Diseases related to High-Grade Astrocytoma

Symptoms & Phenotypes for High-Grade Astrocytoma

MGI Mouse Phenotypes related to High-Grade Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.76 ACVR1 AMFR FLNA GPI IDH1 PARP1
2 homeostasis/metabolism MP:0005376 9.65 ACVR1 AMFR FLNA GPI IDH1 KLK6
3 immune system MP:0005387 9.23 ACVR1 AMFR FLNA GPI IDH1 PARP1

Drugs & Therapeutics for High-Grade Astrocytoma

Drugs for High-Grade Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Melphalan Approved Phase 2, Phase 3 148-82-3 460612 4053
4
Thiotepa Approved, Investigational Phase 2, Phase 3 52-24-4 5453
5
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 498142 38904
6 Etoposide phosphate Phase 2, Phase 3
7
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
8
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
9
leucovorin Approved Phase 2 58-05-9 143 6006
10
Procarbazine Approved, Investigational Phase 2 671-16-9 4915
11
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
12
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
13
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
14
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
15
Bevacizumab Approved, Investigational Phase 2 216974-75-3
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
17
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
18 Hormone Antagonists Phase 2
19 Tubulin Modulators Phase 2
20 Alkylating Agents Phase 2
21 Folic Acid Antagonists Phase 2
22 Antidotes Phase 2
23 Antineoplastic Agents, Phytogenic Phase 2
24 Hormones Phase 2
25 glucocorticoids Phase 2
26 Anti-Inflammatory Agents Phase 2
27 Immunologic Factors Phase 2
28 Antineoplastic Agents, Hormonal Phase 2
29 Folate Phase 2
30 Vitamin B Complex Phase 2
31 Protective Agents Phase 2
32 Vitamin B9 Phase 2
33 Immunosuppressive Agents Phase 2
34 Dermatologic Agents Phase 2
35 Nucleic Acid Synthesis Inhibitors Phase 2
36 Calcium, Dietary Phase 2
37 Antineoplastic Agents, Alkylating Phase 2
38 Antimitotic Agents Phase 2
39 Antimetabolites Phase 2
40 Antimetabolites, Antineoplastic Phase 2
41 Antirheumatic Agents Phase 2
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
43 Phosphoramide Mustards Phase 2
44 Angiogenesis Inhibitors Phase 2
45 Angiogenesis Modulating Agents Phase 2
46 Antineoplastic Agents, Immunological Phase 2
47
Pentoxifylline Approved, Investigational Phase 1 6493-05-6 4740
48
Hydroxyurea Approved Phase 1 127-07-1 3657
49 Antioxidants Phase 1
50 Radiation-Protective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Prospective Study of Sequential Myeloablative Chemotherapy With Stem Cell Rescue for the Treatment of Selected High Risk CNS Tumors and Recurrent CNS Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Phase II Study of Methotrexate, Mechlorethamine, Vincristine, Prednisone, and Procarbazine (MMOPP) as Primary Therapy in Infants or Young Children With Primitive Neuroectodermal Tumors or High-Grade Astrocytoma Completed NCT00002463 Phase 2 MOPP Regimen;Leucovorin Calcium;Mechlorethamine Hydrochloride;Methotrexate;Prednisone;Procarbazine Hydrochloride;Vincristine Sulfate
3 A Phase I/II Study of Col-3 Administered on a Continuous Daily Oral Schedule in Patients With Recurrent High-Grade Astrocytoma Completed NCT00004147 Phase 1, Phase 2 incyclinide
4 A Phase 2, Investigator Initiated Study to Determine the Safety, Efficacy and CNS Penetration of TH-302 in Recurrent High Grade Astrocytoma Following Bevacizumab Completed NCT01403610 Phase 2 TH-302 preoperative;Placebo;TH-302 (escalating) with bevacizumab 10mg/kg
5 A Phase 2 Investigator Initiated Study to Determine the Efficacy and Safety of TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma Recruiting NCT03032484 Phase 2 Bevacizumab;TVB-2640
6 A Phase II Study of Binimetinib in Combination With Encorafenib in Adults With Recurrent BRAF V600-Mutated High-Grade Astrocytoma or Other Primary Brain Tumor Not yet recruiting NCT03973918 Phase 2 Encorafenib;Binimetinib
7 A PHASE I STUDY OF COMBINED RADIATION RESPONSE MODIFIERS EMPLOYING HYDROXYUREA AND PENTOXIFYLLINE FOR TREATMENT OF GLIOBLASTOMA Completed NCT00019058 Phase 1 chemotherapy;hydroxyurea;pentoxifylline
8 Organoids Derived From Induced-Pluripotent Stem Cells (iPS) From Patients Recruiting NCT03971812

Search NIH Clinical Center for High-Grade Astrocytoma

Genetic Tests for High-Grade Astrocytoma

Anatomical Context for High-Grade Astrocytoma

MalaCards organs/tissues related to High-Grade Astrocytoma:

41
Brain, Spinal Cord, Bone, Breast, Endothelial, Liver, Lung

Publications for High-Grade Astrocytoma

Articles related to High-Grade Astrocytoma:

(show top 50) (show all 296)
# Title Authors PMID Year
1
Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations. 38
30972500 2019
2
Usefulness of [11C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma. 38
30996153 2019
3
Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy. 38
30624746 2019
4
Regorafenib in patients with recurrent high-grade astrocytoma. 38
30820715 2019
5
Supratentorial high-grade astrocytoma with leptomeningeal spread to the fourth ventricle: a lethal dissemination with dismal prognosis. 38
30604394 2019
6
Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region. 38
30901758 2019
7
Significance of Amphiregulin (AREG) for the Outcome of Low and High Grade Astrocytoma Patients. 38
31031857 2019
8
Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children. 38
30660880 2019
9
Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients. 38
30071292 2018
10
Durable Response to Nivolumab in a Pediatric Patient with Refractory Glioblastoma and Constitutional Biallelic Mismatch Repair Deficiency. 38
30104292 2018
11
Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors. 38
29238007 2018
12
Gene expression microarray analysis reveals prognostic markers of survival in high grade astrocytomas. 38
29781781 2018
13
MR Imaging Features of Anaplastic Pleomorphic Xanthoastrocytoma Mimicking High-Grade Astrocytoma. 38
29903923 2018
14
A Rare Case of Metastases from a High-grade Astrocytoma to the Pleura, Bones, and Liver within Six Months of Diagnosis. 38
30410840 2018
15
Evaluation of high-grade astrocytoma recurrence patterns after radiotherapy in the era of temozolomide: A single institution experience. 38
29760590 2018
16
Cerebellar high-grade astrocytoma with IDH mutations in the elderly: A report of two cases. 38
29635724 2018
17
Vessel Morphologies of the Brain in Cytological Squash Preparations Are Useful for Intraoperative Diagnosis of High-Grade Astrocytomas. 38
29621779 2018
18
Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging. 38
30026674 2018
19
Region-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma. 38
27975172 2018
20
Glioblastoma Multiforme in a Patient with Multiple Myeloma: A Case Report and Literature Review. 38
29616908 2018
21
Long-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma. 38
28791452 2017
22
Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma. 38
27999986 2017
23
A case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades. 38
28185325 2017
24
[Clinical effects of microsurgery in spinal cord anaplastic astrocytoma]. 38
28592077 2017
25
High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients. 38
28339043 2017
26
Gene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma 38
28610419 2017
27
Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas. 38
28513547 2017
28
Distant spread of a supratentorial glioblastoma to the spinal cord. 38
28089418 2017
29
Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma. 38
27834733 2017
30
IDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours. 38
28928859 2017
31
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. 38
26984877 2016
32
Relationship Between Cytogenetic Complexity and Peritumoral Edema in High-Grade Astrocytoma. 38
27578512 2016
33
Successful Management of Intraoperative Acute Bilateral Pulmonary Embolism in a High Grade Astrocytoma Patient. 38
27578311 2016
34
Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran. 38
27822343 2016
35
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma. 38
27460417 2016
36
The role of connexin43-Src interaction in astrocytomas: A molecular puzzle. 38
25711938 2016
37
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults. 38
26848927 2016
38
A comparison study of (11)C-methionine and (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scans in evaluation of patients with recurrent brain tumors. 38
27095856 2016
39
High-grade glioma in children and adolescents: a single-center experience. 38
26679932 2016
40
Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls. 38
27462365 2016
41
Simultaneous 11C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging of Suspected Primary Brain Tumors. 38
27907162 2016
42
Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging. 38
26002128 2015
43
Nitroproteins in Human Astrocytomas Discovered by Gel Electrophoresis and Tandem Mass Spectrometry. 38
26450359 2015
44
Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma. 38
26351319 2015
45
Anaplastic astrocytoma mimicking herpes simplex encephalitis in 13-year old girl. 38
26272584 2015
46
MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma. 38
26286747 2015
47
Combined therapies of antithrombotics and antioxidants delay in silico brain tumour progression. 38
24562299 2015
48
Radio-chemotherapy improves survival in IDH-mutant, 1p/19q non-codeleted secondary high-grade astrocytoma patients. 38
26033545 2015
49
Prognostic significance of multiple kallikreins in high-grade astrocytoma. 38
26231762 2015
50
Study of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected under fluorescein fluorescence guidance. 38
25839919 2015

Variations for High-Grade Astrocytoma

Expression for High-Grade Astrocytoma

Search GEO for disease gene expression data for High-Grade Astrocytoma.

Pathways for High-Grade Astrocytoma

Pathways related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.48 KLK9 KLK7 KLK6

GO Terms for High-Grade Astrocytoma

Cellular components related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 TGFB2 PTEN KLK9 KLK7 KLK6 IDH1
2 secretory granule GO:0030141 9.13 KLK9 KLK7 KLK6

Biological processes related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.72 TGFB2 PTEN ACVR1
2 ventricular septum morphogenesis GO:0060412 9.54 TGFB2 ACVR1
3 response to progesterone GO:0032570 9.52 TGFB2 GPI
4 mesoderm formation GO:0001707 9.51 GPI ACVR1
5 transforming growth factor beta receptor signaling pathway GO:0007179 9.5 TGFB2 PARP1 ACVR1
6 regulation of neuron projection development GO:0010975 9.49 PTEN KLK6
7 outflow tract septum morphogenesis GO:0003148 9.48 TGFB2 ACVR1
8 endocardial cushion morphogenesis GO:0003203 9.46 TGFB2 ACVR1
9 protein autoprocessing GO:0016540 9.43 PARP1 KLK6
10 pathway-restricted SMAD protein phosphorylation GO:0060389 9.4 TGFB2 ACVR1
11 atrioventricular valve morphogenesis GO:0003181 9.37 TGFB2 ACVR1
12 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.26 TGFB2 ACVR1
13 atrial septum primum morphogenesis GO:0003289 9.16 TGFB2 ACVR1
14 learning or memory GO:0007611 9.13 PTEN GPI AMFR
15 endocardial cushion fusion GO:0003274 8.62 TGFB2 ACVR1

Molecular functions related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.5 KLK9 KLK7 KLK6
2 serine-type peptidase activity GO:0008236 9.33 KLK9 KLK7 KLK6
3 NAD binding GO:0051287 9.26 PARP1 IDH1
4 ubiquitin-specific protease binding GO:1990381 8.96 PTEN AMFR
5 SMAD binding GO:0046332 8.8 PARP1 FLNA ACVR1

Sources for High-Grade Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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