MCID: HGH041
MIFTS: 36

High-Grade Astrocytoma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for High-Grade Astrocytoma

MalaCards integrated aliases for High-Grade Astrocytoma:

Name: High-Grade Astrocytoma 58 6

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA251561

Summaries for High-Grade Astrocytoma

MalaCards based summary : High-Grade Astrocytoma is related to malignant astrocytoma and anaplastic astrocytoma. An important gene associated with High-Grade Astrocytoma is ATRX (ATRX Chromatin Remodeler), and among its related pathways/superpathways are TP53 Regulates Metabolic Genes and Central carbon metabolism in cancer. The drugs Melphalan and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and endothelial, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for High-Grade Astrocytoma

Diseases related to High-Grade Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 malignant astrocytoma 30.7 TP53 PTEN IDH1 ATRX
2 anaplastic astrocytoma 30.3 TP53 PTEN IDH1 ATRX
3 low-grade astrocytoma 30.2 TP53 IDH1
4 glioma 30.1 TP53 TGFB2 PTEN IDH1
5 diffuse astrocytoma 29.8 TP53 IDH1 ATRX
6 pleomorphic xanthoastrocytoma 29.5 TP53 IDH1 ATRX
7 diffuse midline glioma, h3 k27m-mutant 29.3 TP53 IDH1 ATRX ACVR1
8 hydrocephalus 29.2 TP53 TGFB2 PTEN NFIA FLNA
9 glioma susceptibility 1 10.9
10 glioblastoma 10.7
11 high grade glioma 10.5
12 glial tumor 10.3
13 keloid formation 10.3 PTEN FLNA
14 postpoliomyelitis syndrome 10.2 KLK9 KLK6
15 large intestine lipoma 10.2 PTEN NFIB
16 lipoma of colon 10.2 PTEN NFIB
17 frontal lobe neoplasm 10.1 TP53 IDH1
18 laryngeal neuroendocrine tumor 10.1 TP53 IDH1
19 brain malformations with or without urinary tract defects 10.1 NFIB NFIA
20 neutropenia 10.1
21 tricuspid valve prolapse 10.1 TGFB2 FLNA
22 endometrioid ovary carcinoma 10.1 TP53 PTEN
23 large intestine adenocarcinoma 10.1 TP53 PTEN
24 cerebellum cancer 10.0 TP53 IDH1
25 gliomatosis cerebri 10.0 TP53 PTEN IDH1
26 brain stem glioma 10.0 TP53 IDH1 ACVR1
27 pleomorphic adenoma carcinoma 10.0 TP53 NFIB
28 uterine corpus endometrial carcinoma 10.0 TP53 PTEN IDH1
29 suppression of tumorigenicity 12 10.0 TP53 PTEN IDH1
30 infratentorial cancer 10.0 TP53 PTEN IDH1
31 klatskin's tumor 10.0 TP53 IDH1
32 bladder urothelial carcinoma 10.0 TP53 PTEN IDH1
33 synchronous bilateral breast carcinoma 10.0 TP53 PTEN NFIB
34 chordoma 10.0 TP53 PTEN IDH1
35 temporal lobe neoplasm 10.0 IDH1 ATRX
36 bladder transitional cell papilloma 10.0 TP53 PARP1
37 oropharynx cancer 10.0 TP53 PTEN NFIB
38 multiple sclerosis 9.9
39 mismatch repair cancer syndrome 1 9.9
40 meningioma, radiation-induced 9.9
41 meningioma, familial 9.9
42 low grade glioma 9.9
43 anaplastic pleomorphic xanthoastrocytoma 9.9
44 mismatch repair cancer syndrome 9.9
45 cysticercosis 9.9
46 spinal meningioma 9.9
47 pancytopenia 9.9
48 facial paralysis 9.9
49 phaeohyphomycosis 9.9
50 normal pressure hydrocephalus 9.9

Graphical network of the top 20 diseases related to High-Grade Astrocytoma:



Diseases related to High-Grade Astrocytoma

Symptoms & Phenotypes for High-Grade Astrocytoma

MGI Mouse Phenotypes related to High-Grade Astrocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.15 ACVR1 AMFR ATRX FLNA GPI IDH1
2 homeostasis/metabolism MP:0005376 10.13 ACVR1 AMFR FLNA GPI IDH1 KLK6
3 mortality/aging MP:0010768 9.97 ACVR1 AMFR ATRX FLNA GPI IDH1
4 immune system MP:0005387 9.96 ACVR1 AMFR FLNA GPI IDH1 KLK6
5 nervous system MP:0003631 9.7 ACVR1 ATRX FLNA KLK6 KLK7 NFIA
6 respiratory system MP:0005388 9.17 FLNA GPI IDH1 NFIB PTEN TGFB2

Drugs & Therapeutics for High-Grade Astrocytoma

Drugs for High-Grade Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 2 148-82-3 4053 460612
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
4
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
5
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
6
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
7
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
8
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
9
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
10
Procarbazine Approved, Investigational Phase 2 671-16-9 4915
11
leucovorin Approved Phase 2 58-05-9 6006
12
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
13
Bevacizumab Approved, Investigational Phase 2 216974-75-3
14
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
15
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
17 Etoposide phosphate Phase 2
18 Micronutrients Phase 2
19 Hormones Phase 2
20 Anti-Inflammatory Agents Phase 2
21 Nutrients Phase 2
22 Vitamin B Complex Phase 2
23 Antimitotic Agents Phase 2
24 Protective Agents Phase 2
25 Immunosuppressive Agents Phase 2
26 Hormone Antagonists Phase 2
27 Trace Elements Phase 2
28 Vitamins Phase 2
29 Immunologic Factors Phase 2
30 Folic Acid Antagonists Phase 2
31 Antimetabolites Phase 2
32 Folate Phase 2
33 Dermatologic Agents Phase 2
34 Vitamin B9 Phase 2
35 Tubulin Modulators Phase 2
36 Calcium, Dietary Phase 2
37 glucocorticoids Phase 2
38 Antirheumatic Agents Phase 2
39 Alkylating Agents Phase 2
40 Antineoplastic Agents, Hormonal Phase 2
41 Antidotes Phase 2
42 Phosphoramide Mustards Phase 2
43 Semaxinib Phase 1, Phase 2
44 Protein Kinase Inhibitors Phase 1, Phase 2
45 Angiogenesis Inhibitors Phase 2
46 Antineoplastic Agents, Immunological Phase 2
47 topoisomerase I inhibitors Phase 2
48
Calcium Nutraceutical Phase 2 7440-70-2 271
49
Temozolomide Approved, Investigational 85622-93-1 5394

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Prospective Study of Sequential Myeloablative Chemotherapy With Stem Cell Rescue for the Treatment of Selected High Risk CNS Tumors and Recurrent CNS Tumors Completed NCT00179803 Phase 2
2 Phase II Study of Methotrexate, Mechlorethamine, Vincristine, Prednisone, and Procarbazine (MMOPP) as Primary Therapy in Infants or Young Children With Primitive Neuroectodermal Tumors or High-Grade Astrocytoma Completed NCT00002463 Phase 2 MOPP Regimen;Leucovorin Calcium;Mechlorethamine Hydrochloride;Methotrexate;Prednisone;Procarbazine Hydrochloride;Vincristine Sulfate
3 A Phase 2, Investigator Initiated Study to Determine the Safety, Efficacy and CNS Penetration of TH-302 in Recurrent High Grade Astrocytoma Following Bevacizumab Completed NCT01403610 Phase 2 TH-302 preoperative;Placebo;TH-302 (escalating) with bevacizumab 10mg/kg
4 A Phase I/II Study of Col-3 Administered on a Continuous Daily Oral Schedule in Patients With Recurrent High-Grade Astrocytoma Completed NCT00004147 Phase 1, Phase 2 incyclinide
5 A Phase I/II Trial of SU5416 in Patients With Recurrent High Grade Astrocytomas or Mixed Gliomas Completed NCT00004868 Phase 1, Phase 2 semaxanib
6 A Phase I/II Study of Oral Procarbazine in the Treatment of Recurrent High Grade Astrocytomas Completed NCT00004004 Phase 1, Phase 2 procarbazine hydrochloride
7 A Phase II Study of Binimetinib in Combination With Encorafenib in Adults With Recurrent BRAF V600-Mutated High-Grade Astrocytoma or Other Primary Brain Tumor Recruiting NCT03973918 Phase 2 Encorafenib;Binimetinib
8 A Phase 2 Investigator Initiated Study to Determine the Efficacy and Safety of TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma Active, not recruiting NCT03032484 Phase 2 Bevacizumab;TVB-2640
9 A Phase II Trial of External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas (POE08-01) Active, not recruiting NCT01012609 Phase 2
10 The Effect of Radiotherapy and Temozolomide on the Tumor Vasculature and Stem Cells in Human High-grade Astrocytomas Terminated NCT00473408

Search NIH Clinical Center for High-Grade Astrocytoma

Genetic Tests for High-Grade Astrocytoma

Anatomical Context for High-Grade Astrocytoma

MalaCards organs/tissues related to High-Grade Astrocytoma:

40
Spinal Cord, Brain, Endothelial, Bone Marrow, Pineal

Publications for High-Grade Astrocytoma

Articles related to High-Grade Astrocytoma:

(show top 50) (show all 304)
# Title Authors PMID Year
1
Canine Gliomatosis Cerebri: Morphologic and Immunohistochemical Characterization Is Supportive of Glial Histogenesis. 61
33357125 2020
2
Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma. 61
32594352 2020
3
<Editors' Choice> Impact of maintenance of postoperative performance status on survival in elderly patients over 70 with high-grade astrocytoma. 61
33132437 2020
4
Development of transient radioresistance during fractionated irradiation in vitro. 61
32344261 2020
5
RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis. 61
32001819 2020
6
Use of High-Dose Chemotherapy in Front-Line Therapy of Infants Aged Less Than 12 Months Treated for Aggressive Brain Tumors. 61
32328470 2020
7
Label-free multiphoton imaging allows brain tumor recognition based on texture analysis-a study of 382 tumor patients. 61
32642692 2020
8
Textiloma Mimicking a Recurrent High-Grade Astrocytoma: A Case Report. 61
32206542 2020
9
Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma. 61
31760595 2020
10
[Visual fluorescence combined with laser spectroscopy in surgery for intramedullary spinal cord tumors]. 61
33306295 2020
11
Nocardia farcinica meningitis in a patient with high-grade astrocytoma. 61
32074098 2019
12
Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations. 61
30972500 2019
13
Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy. 61
30624746 2019
14
Usefulness of [11C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma. 61
30996153 2019
15
Supratentorial high-grade astrocytoma with leptomeningeal spread to the fourth ventricle: a lethal dissemination with dismal prognosis. 61
30604394 2019
16
Regorafenib in patients with recurrent high-grade astrocytoma. 61
30820715 2019
17
Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region. 61
30901758 2019
18
Significance of Amphiregulin (AREG) for the Outcome of Low and High Grade Astrocytoma Patients. 61
31031857 2019
19
Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children. 61
30660880 2019
20
Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients. 61
30071292 2018
21
Durable Response to Nivolumab in a Pediatric Patient with Refractory Glioblastoma and Constitutional Biallelic Mismatch Repair Deficiency. 61
30104292 2018
22
Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors. 61
29238007 2018
23
Gene expression microarray analysis reveals prognostic markers of survival in high grade astrocytomas. 61
29781781 2018
24
MR Imaging Features of Anaplastic Pleomorphic Xanthoastrocytoma Mimicking High-Grade Astrocytoma. 61
29903923 2018
25
A Rare Case of Metastases from a High-grade Astrocytoma to the Pleura, Bones, and Liver within Six Months of Diagnosis. 61
30410840 2018
26
Evaluation of high-grade astrocytoma recurrence patterns after radiotherapy in the era of temozolomide: A single institution experience. 61
29760590 2018
27
Cerebellar high-grade astrocytoma with IDH mutations in the elderly: A report of two cases. 61
29635724 2018
28
Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging. 61
30026674 2018
29
Region-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma. 61
27975172 2018
30
Vessel Morphologies of the Brain in Cytological Squash Preparations Are Useful for Intraoperative Diagnosis of High-Grade Astrocytomas. 61
29621779 2018
31
Glioblastoma Multiforme in a Patient with Multiple Myeloma: A Case Report and Literature Review. 61
29616908 2018
32
Long-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma. 61
28791452 2017
33
A case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades. 61
28185325 2017
34
Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma. 61
27999986 2017
35
[Clinical effects of microsurgery in spinal cord anaplastic astrocytoma]. 61
28592077 2017
36
Gene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma 61
28610419 2017
37
High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients. 61
28339043 2017
38
Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas. 61
28513547 2017
39
Distant spread of a supratentorial glioblastoma to the spinal cord. 61
28089418 2017
40
IDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours. 61
28928859 2017
41
Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma. 61
27834733 2017
42
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. 61
26984877 2016
43
Relationship Between Cytogenetic Complexity and Peritumoral Edema in High-Grade Astrocytoma. 61
27578512 2016
44
Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran. 61
27822343 2016
45
Successful Management of Intraoperative Acute Bilateral Pulmonary Embolism in a High Grade Astrocytoma Patient. 61
27578311 2016
46
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma. 61
27460417 2016
47
The role of connexin43-Src interaction in astrocytomas: A molecular puzzle. 61
25711938 2016
48
A comparison study of (11)C-methionine and (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scans in evaluation of patients with recurrent brain tumors. 61
27095856 2016
49
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults. 61
26848927 2016
50
High-grade glioma in children and adolescents: a single-center experience. 61
26679932 2016

Variations for High-Grade Astrocytoma

ClinVar genetic disease variations for High-Grade Astrocytoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TP53 NM_000546.6(TP53):c.844C>T (p.Arg282Trp) SNV Pathogenic 12364 rs28934574 17:7577094-7577094 17:7673776-7673776
2 TP53 NM_000546.6(TP53):c.733G>A (p.Gly245Ser) SNV Pathogenic 12365 rs28934575 17:7577548-7577548 17:7674230-7674230
3 ATRX NM_000489.5(ATRX):c.5579A>G (p.Asn1860Ser) SNV Pathogenic 11724 rs45439799 X:76856021-76856021 X:77600552-77600552

Expression for High-Grade Astrocytoma

Search GEO for disease gene expression data for High-Grade Astrocytoma.

Pathways for High-Grade Astrocytoma

Pathways related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.36 TP53 PTEN GPI
2 11.18 TP53 PTEN IDH1
3 10.81 KLK9 KLK7 KLK6
4 10.74 TP53 PTEN NFIB ATRX

GO Terms for High-Grade Astrocytoma

Cellular components related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 TGFB2 PTEN KLK9 KLK7 KLK6 IDH1
2 PML body GO:0016605 9.13 TP53 PTEN ATRX
3 secretory granule GO:0030141 8.8 KLK9 KLK7 KLK6

Biological processes related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 TP53 PARP1 NFIB NFIA ATRX ACVR1
2 heart development GO:0007507 9.71 TP53 TGFB2 PTEN ACVR1
3 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.54 TP53 PTEN
4 learning or memory GO:0007611 9.54 PTEN GPI AMFR
5 endocardial cushion morphogenesis GO:0003203 9.52 TGFB2 ACVR1
6 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.51 TP53 ATRX
7 pathway-restricted SMAD protein phosphorylation GO:0060389 9.48 TGFB2 ACVR1
8 atrioventricular valve morphogenesis GO:0003181 9.46 TGFB2 ACVR1
9 synapse maturation GO:0060074 9.43 PTEN NFIA
10 mitochondrial DNA repair GO:0043504 9.32 TP53 PARP1
11 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.26 TGFB2 ACVR1
12 atrial septum primum morphogenesis GO:0003289 9.16 TGFB2 ACVR1
13 endocardial cushion fusion GO:0003274 8.96 TGFB2 ACVR1
14 transforming growth factor beta receptor signaling pathway GO:0007179 8.92 TP53 TGFB2 PARP1 ACVR1

Molecular functions related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.26 TP53 PARP1 NFIA FLNA
2 ubiquitin-specific protease binding GO:1990381 9.16 PTEN AMFR
3 SMAD binding GO:0046332 8.8 PARP1 FLNA ACVR1

Sources for High-Grade Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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