MCID: HGH041
MIFTS: 32

High-Grade Astrocytoma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for High-Grade Astrocytoma

MalaCards integrated aliases for High-Grade Astrocytoma:

Name: High-Grade Astrocytoma 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA251561

Summaries for High-Grade Astrocytoma

MalaCards based summary : High-Grade Astrocytoma is related to glial tumor and fibrillary astrocytoma. An important gene associated with High-Grade Astrocytoma is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways is MSP-RON Signaling. The drugs Etoposide and Thiotepa have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for High-Grade Astrocytoma

Diseases related to High-Grade Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 glial tumor 31.2 PTEN IDH1
2 fibrillary astrocytoma 30.4 PTEN IDH1
3 hydrocephalus 29.2 TGFB2 PTEN NFIA FLNA
4 astrocytoma 11.0
5 glioblastoma multiforme 10.8
6 grade iii astrocytoma 10.7
7 glioma 10.6
8 breast duct papilloma 10.3 PTEN IDH1
9 glioma susceptibility 1 10.3
10 malignant glioma 10.3
11 low-grade astrocytoma 10.3
12 gemistocytic astrocytoma 10.3 PTEN IDH1
13 keloid formation 10.3 PTEN FLNA
14 adult astrocytic tumour 10.3 PTEN IDH1
15 mixed oligodendroglioma-astrocytoma 10.3 PTEN IDH1
16 interval angle-closure glaucoma 10.2 IDH1 FLNA
17 mixed glioma 10.2 PTEN IDH1
18 brain cancer 10.2
19 breast cancer 10.2
20 neutropenia 10.2
21 childhood brain stem glioma 10.2 IDH1 ACVR1
22 brain stem glioma 10.1 PTEN IDH1 ACVR1
23 brain stem cancer 10.1 IDH1 ACVR1
24 infratentorial cancer 10.1 PTEN IDH1 ACVR1
25 postpoliomyelitis syndrome 10.1 KLK9 KLK6
26 retinoblastoma 10.1
27 lymphoma 10.1
28 diffuse midline glioma, h3 k27m-mutant 10.1
29 oligodendroglioma 10.1
30 familial retinoblastoma 10.1
31 pleomorphic xanthoastrocytoma 10.1
32 juvenile pilocytic astrocytoma 10.1
33 brain tumor, childhood 10.1
34 gastroesophageal adenocarcinoma 10.0 PTEN KLK6
35 gliomatosis cerebri 10.0 PTEN IDH1
36 multiple sclerosis 9.9
37 medulloblastoma 9.9
38 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
39 mismatch repair cancer syndrome 9.9
40 meningioma, radiation-induced 9.9
41 meningioma, familial 9.9
42 exanthem 9.9
43 cysticercosis 9.9
44 spinal meningioma 9.9
45 pancytopenia 9.9
46 facial paralysis 9.9
47 phaeohyphomycosis 9.9
48 normal pressure hydrocephalus 9.9
49 supratentorial cancer 9.9
50 central nervous system lymphoma 9.9

Graphical network of the top 20 diseases related to High-Grade Astrocytoma:



Diseases related to High-Grade Astrocytoma

Symptoms & Phenotypes for High-Grade Astrocytoma

MGI Mouse Phenotypes related to High-Grade Astrocytoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.02 ACVR1 AMFR FLNA GPI IDH1 NFIA
2 homeostasis/metabolism MP:0005376 10 ACVR1 AMFR FLNA GPI IDH1 KLK6
3 mortality/aging MP:0010768 9.85 ACVR1 AMFR FLNA GPI IDH1 NFIA
4 nervous system MP:0003631 9.61 ACVR1 FLNA KLK6 KLK7 NFIA NFIB
5 respiratory system MP:0005388 9.1 FLNA GPI IDH1 NFIB PTEN TGFB2

Drugs & Therapeutics for High-Grade Astrocytoma

Drugs for High-Grade Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
2
Thiotepa Approved, Investigational Phase 2, Phase 3 52-24-4 5453
3
Melphalan Approved Phase 2, Phase 3 148-82-3 460612 4053
4
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 38904 498142
5
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
6 Etoposide phosphate Phase 2, Phase 3
7
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
8
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
9
leucovorin Approved Phase 2 58-05-9 6006 143
10
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
11
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
12
Procarbazine Approved, Investigational Phase 2 671-16-9 4915
13
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
14
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
15
Bevacizumab Approved, Investigational Phase 2 216974-75-3
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
17 Micronutrients Phase 2
18 Hormones Phase 2
19 Vitamins Phase 2
20 Antidotes Phase 2
21 Vitamin B Complex Phase 2
22 Antineoplastic Agents, Hormonal Phase 2
23 Immunologic Factors Phase 2
24 Folate Phase 2
25 Hormone Antagonists Phase 2
26 Folic Acid Antagonists Phase 2
27 Alkylating Agents Phase 2
28 glucocorticoids Phase 2
29 Nutrients Phase 2
30 Immunosuppressive Agents Phase 2
31 Vitamin B9 Phase 2
32 Calcium, Dietary Phase 2
33 Tubulin Modulators Phase 2
34 Trace Elements Phase 2
35 Dermatologic Agents Phase 2
36 Antimetabolites Phase 2
37 Anti-Inflammatory Agents Phase 2
38 Antirheumatic Agents Phase 2
39 Antimitotic Agents Phase 2
40 Protective Agents Phase 2
41 Phosphoramide Mustards Phase 2
42 Angiogenesis Inhibitors Phase 2
43 Antineoplastic Agents, Immunological Phase 2
44
Calcium Nutraceutical Phase 2 7440-70-2 271
45
Pentoxifylline Approved, Investigational Phase 1 6493-05-6 4740
46
Hydroxyurea Approved Phase 1 127-07-1 3657
47 Phosphodiesterase Inhibitors Phase 1
48 Antioxidants Phase 1
49 Vasodilator Agents Phase 1
50 Platelet Aggregation Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Prospective Study of Sequential Myeloablative Chemotherapy With Stem Cell Rescue for the Treatment of Selected High Risk CNS Tumors and Recurrent CNS Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Phase II Study of Methotrexate, Mechlorethamine, Vincristine, Prednisone, and Procarbazine (MMOPP) as Primary Therapy in Infants or Young Children With Primitive Neuroectodermal Tumors or High-Grade Astrocytoma Completed NCT00002463 Phase 2 MOPP Regimen;Leucovorin Calcium;Mechlorethamine Hydrochloride;Methotrexate;Prednisone;Procarbazine Hydrochloride;Vincristine Sulfate
3 A Phase I/II Study of Col-3 Administered on a Continuous Daily Oral Schedule in Patients With Recurrent High-Grade Astrocytoma Completed NCT00004147 Phase 1, Phase 2 incyclinide
4 A Phase 2, Investigator Initiated Study to Determine the Safety, Efficacy and CNS Penetration of TH-302 in Recurrent High Grade Astrocytoma Following Bevacizumab Completed NCT01403610 Phase 2 TH-302 preoperative;Placebo;TH-302 (escalating) with bevacizumab 10mg/kg
5 A Phase II Study of Binimetinib in Combination With Encorafenib in Adults With Recurrent BRAF V600-Mutated High-Grade Astrocytoma or Other Primary Brain Tumor Recruiting NCT03973918 Phase 2 Encorafenib;Binimetinib
6 A Phase 2 Investigator Initiated Study to Determine the Efficacy and Safety of TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma Active, not recruiting NCT03032484 Phase 2 Bevacizumab;TVB-2640
7 A PHASE I STUDY OF COMBINED RADIATION RESPONSE MODIFIERS EMPLOYING HYDROXYUREA AND PENTOXIFYLLINE FOR TREATMENT OF GLIOBLASTOMA Completed NCT00019058 Phase 1 chemotherapy;hydroxyurea;pentoxifylline
8 Organoids Derived From Induced-Pluripotent Stem Cells (iPS) From Patients Recruiting NCT03971812

Search NIH Clinical Center for High-Grade Astrocytoma

Genetic Tests for High-Grade Astrocytoma

Anatomical Context for High-Grade Astrocytoma

MalaCards organs/tissues related to High-Grade Astrocytoma:

40
Brain, Spinal Cord, Bone, Breast, Endothelial, Liver, Lung

Publications for High-Grade Astrocytoma

Articles related to High-Grade Astrocytoma:

(show top 50) (show all 302)
# Title Authors PMID Year
1
Development of transient radioresistance during fractionated irradiation in vitro. 61
32344261 2020
2
RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis. 61
32001819 2020
3
Use of High-Dose Chemotherapy in Front-Line Therapy of Infants Aged Less Than 12 Months Treated for Aggressive Brain Tumors. 61
32328470 2020
4
Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma. 61
31760595 2020
5
Textiloma Mimicking a Recurrent High-Grade Astrocytoma: A Case Report. 61
32206542 2020
6
Nocardia farcinica meningitis in a patient with high-grade astrocytoma. 61
32074098 2019
7
Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations. 61
30972500 2019
8
Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy. 61
30624746 2019
9
Usefulness of [11C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma. 61
30996153 2019
10
Regorafenib in patients with recurrent high-grade astrocytoma. 61
30820715 2019
11
Supratentorial high-grade astrocytoma with leptomeningeal spread to the fourth ventricle: a lethal dissemination with dismal prognosis. 61
30604394 2019
12
Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region. 61
30901758 2019
13
Significance of Amphiregulin (AREG) for the Outcome of Low and High Grade Astrocytoma Patients. 61
31031857 2019
14
Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children. 61
30660880 2019
15
Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients. 61
30071292 2018
16
Durable Response to Nivolumab in a Pediatric Patient with Refractory Glioblastoma and Constitutional Biallelic Mismatch Repair Deficiency. 61
30104292 2018
17
Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors. 61
29238007 2018
18
Gene expression microarray analysis reveals prognostic markers of survival in high grade astrocytomas. 61
29781781 2018
19
A Rare Case of Metastases from a High-grade Astrocytoma to the Pleura, Bones, and Liver within Six Months of Diagnosis. 61
30410840 2018
20
MR Imaging Features of Anaplastic Pleomorphic Xanthoastrocytoma Mimicking High-Grade Astrocytoma. 61
29903923 2018
21
Evaluation of high-grade astrocytoma recurrence patterns after radiotherapy in the era of temozolomide: A single institution experience. 61
29760590 2018
22
Cerebellar high-grade astrocytoma with IDH mutations in the elderly: A report of two cases. 61
29635724 2018
23
Vessel Morphologies of the Brain in Cytological Squash Preparations Are Useful for Intraoperative Diagnosis of High-Grade Astrocytomas. 61
29621779 2018
24
Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging. 61
30026674 2018
25
Region-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma. 61
27975172 2018
26
Glioblastoma Multiforme in a Patient with Multiple Myeloma: A Case Report and Literature Review. 61
29616908 2018
27
Long-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma. 61
28791452 2017
28
Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma. 61
27999986 2017
29
A case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades. 61
28185325 2017
30
[Clinical effects of microsurgery in spinal cord anaplastic astrocytoma]. 61
28592077 2017
31
High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients. 61
28339043 2017
32
Gene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma 61
28610419 2017
33
Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas. 61
28513547 2017
34
Distant spread of a supratentorial glioblastoma to the spinal cord. 61
28089418 2017
35
Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma. 61
27834733 2017
36
IDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours. 61
28928859 2017
37
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. 61
26984877 2016
38
Relationship Between Cytogenetic Complexity and Peritumoral Edema in High-Grade Astrocytoma. 61
27578512 2016
39
Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran. 61
27822343 2016
40
Successful Management of Intraoperative Acute Bilateral Pulmonary Embolism in a High Grade Astrocytoma Patient. 61
27578311 2016
41
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma. 61
27460417 2016
42
The role of connexin43-Src interaction in astrocytomas: A molecular puzzle. 61
25711938 2016
43
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults. 61
26848927 2016
44
A comparison study of (11)C-methionine and (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scans in evaluation of patients with recurrent brain tumors. 61
27095856 2016
45
High-grade glioma in children and adolescents: a single-center experience. 61
26679932 2016
46
Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls. 61
27462365 2016
47
Simultaneous 11C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging of Suspected Primary Brain Tumors. 61
27907162 2016
48
Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging. 61
26002128 2015
49
Nitroproteins in Human Astrocytomas Discovered by Gel Electrophoresis and Tandem Mass Spectrometry. 61
26450359 2015
50
Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma. 61
26351319 2015

Variations for High-Grade Astrocytoma

Expression for High-Grade Astrocytoma

Search GEO for disease gene expression data for High-Grade Astrocytoma.

Pathways for High-Grade Astrocytoma

Pathways related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.48 KLK9 KLK7 KLK6

GO Terms for High-Grade Astrocytoma

Cellular components related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 TGFB2 PTEN KLK9 KLK7 KLK6 IDH1
2 secretory granule GO:0030141 9.13 KLK9 KLK7 KLK6

Biological processes related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor signaling pathway GO:0007179 9.61 TGFB2 PARP1 ACVR1
2 outflow tract septum morphogenesis GO:0003148 9.49 TGFB2 ACVR1
3 protein autoprocessing GO:0016540 9.48 PARP1 KLK6
4 endocardial cushion morphogenesis GO:0003203 9.46 TGFB2 ACVR1
5 learning or memory GO:0007611 9.43 PTEN GPI AMFR
6 pathway-restricted SMAD protein phosphorylation GO:0060389 9.4 TGFB2 ACVR1
7 synapse maturation GO:0060074 9.37 PTEN NFIA
8 atrioventricular valve morphogenesis GO:0003181 9.32 TGFB2 ACVR1
9 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.16 TGFB2 ACVR1
10 atrial septum primum morphogenesis GO:0003289 8.96 TGFB2 ACVR1
11 endocardial cushion fusion GO:0003274 8.62 TGFB2 ACVR1

Molecular functions related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.43 KLK9 KLK7 KLK6
2 serine-type peptidase activity GO:0008236 9.33 KLK9 KLK7 KLK6
3 protein tyrosine kinase binding GO:1990782 9.32 PTEN ACVR1
4 ubiquitin-specific protease binding GO:1990381 8.96 PTEN AMFR
5 SMAD binding GO:0046332 8.8 PARP1 FLNA ACVR1

Sources for High-Grade Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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