MCID: HGH041
MIFTS: 32

High-Grade Astrocytoma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for High-Grade Astrocytoma

MalaCards integrated aliases for High-Grade Astrocytoma:

Name: High-Grade Astrocytoma 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA251561

Summaries for High-Grade Astrocytoma

MalaCards based summary : High-Grade Astrocytoma is related to glial tumor and fibrillary astrocytoma. An important gene associated with High-Grade Astrocytoma is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways is MSP-RON Signaling. The drugs Etoposide and Thiotepa have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for High-Grade Astrocytoma

Diseases related to High-Grade Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 66, show less)
# Related Disease Score Top Affiliating Genes
1 glial tumor 31.2 PTEN IDH1
2 fibrillary astrocytoma 30.4 PTEN IDH1
3 hydrocephalus 29.2 TGFB2 PTEN NFIA FLNA
4 astrocytoma 11.0
5 glioblastoma multiforme 10.8
6 grade iii astrocytoma 10.7
7 glioma 10.6
8 breast duct papilloma 10.3 PTEN IDH1
9 glioma susceptibility 1 10.3
10 malignant glioma 10.3
11 low-grade astrocytoma 10.3
12 gemistocytic astrocytoma 10.3 PTEN IDH1
13 keloid formation 10.3 PTEN FLNA
14 adult astrocytic tumour 10.3 PTEN IDH1
15 mixed oligodendroglioma-astrocytoma 10.3 PTEN IDH1
16 interval angle-closure glaucoma 10.2 IDH1 FLNA
17 mixed glioma 10.2 PTEN IDH1
18 brain cancer 10.2
19 breast cancer 10.2
20 neutropenia 10.2
21 childhood brain stem glioma 10.2 IDH1 ACVR1
22 brain stem glioma 10.1 PTEN IDH1 ACVR1
23 brain stem cancer 10.1 IDH1 ACVR1
24 infratentorial cancer 10.1 PTEN IDH1 ACVR1
25 postpoliomyelitis syndrome 10.1 KLK9 KLK6
26 retinoblastoma 10.1
27 lymphoma 10.1
28 diffuse midline glioma, h3 k27m-mutant 10.1
29 oligodendroglioma 10.1
30 familial retinoblastoma 10.1
31 pleomorphic xanthoastrocytoma 10.1
32 juvenile pilocytic astrocytoma 10.1
33 brain tumor, childhood 10.1
34 gastroesophageal adenocarcinoma 10.0 PTEN KLK6
35 gliomatosis cerebri 10.0 PTEN IDH1
36 multiple sclerosis 9.9
37 medulloblastoma 9.9
38 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
39 mismatch repair cancer syndrome 9.9
40 meningioma, radiation-induced 9.9
41 meningioma, familial 9.9
42 exanthem 9.9
43 cysticercosis 9.9
44 spinal meningioma 9.9
45 pancytopenia 9.9
46 facial paralysis 9.9
47 phaeohyphomycosis 9.9
48 normal pressure hydrocephalus 9.9
49 supratentorial cancer 9.9
50 central nervous system lymphoma 9.9
51 vaccinia 9.9
52 secretory meningioma 9.9
53 lymphoplasmacyte-rich meningioma 9.9
54 peripheral nervous system disease 9.9
55 lymphopenia 9.9
56 severe combined immunodeficiency 9.9
57 neuropathy 9.9
58 neurofibromatosis 9.9
59 meningitis 9.9
60 pulmonary embolism 9.9
61 anaplastic oligodendroglioma 9.9
62 anaplastic pleomorphic xanthoastrocytoma 9.9
63 primary central nervous system lymphoma 9.9
64 spinal cord injury 9.9
65 rare tumor 9.9
66 marshall-smith syndrome 9.9 NFIB NFIA

Graphical network of the top 20 diseases related to High-Grade Astrocytoma:



Diseases related to High-Grade Astrocytoma

Symptoms & Phenotypes for High-Grade Astrocytoma

MGI Mouse Phenotypes related to High-Grade Astrocytoma:

45 (showing 5, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.02 ACVR1 AMFR FLNA GPI IDH1 NFIA
2 homeostasis/metabolism MP:0005376 10 ACVR1 AMFR FLNA GPI IDH1 KLK6
3 mortality/aging MP:0010768 9.85 ACVR1 AMFR FLNA GPI IDH1 NFIA
4 nervous system MP:0003631 9.61 ACVR1 FLNA KLK6 KLK7 NFIA NFIB
5 respiratory system MP:0005388 9.1 FLNA GPI IDH1 NFIB PTEN TGFB2

Drugs & Therapeutics for High-Grade Astrocytoma

Drugs for High-Grade Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 51, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
2
Thiotepa Approved, Investigational Phase 2, Phase 3 52-24-4 5453
3
Melphalan Approved Phase 2, Phase 3 148-82-3 460612 4053
4
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 38904 498142
5
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
6 Etoposide phosphate Phase 2, Phase 3
7
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
8
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
9
leucovorin Approved Phase 2 58-05-9 6006 143
10
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
11
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
12
Procarbazine Approved, Investigational Phase 2 671-16-9 4915
13
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
14
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
15
Bevacizumab Approved, Investigational Phase 2 216974-75-3
16
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
17 Micronutrients Phase 2
18 Hormones Phase 2
19 Vitamins Phase 2
20 Antidotes Phase 2
21 Vitamin B Complex Phase 2
22 Antineoplastic Agents, Hormonal Phase 2
23 Immunologic Factors Phase 2
24 Folate Phase 2
25 Hormone Antagonists Phase 2
26 Folic Acid Antagonists Phase 2
27 Alkylating Agents Phase 2
28 glucocorticoids Phase 2
29 Nutrients Phase 2
30 Immunosuppressive Agents Phase 2
31 Vitamin B9 Phase 2
32 Calcium, Dietary Phase 2
33 Tubulin Modulators Phase 2
34 Trace Elements Phase 2
35 Dermatologic Agents Phase 2
36 Antimetabolites Phase 2
37 Anti-Inflammatory Agents Phase 2
38 Antirheumatic Agents Phase 2
39 Antimitotic Agents Phase 2
40 Protective Agents Phase 2
41 Phosphoramide Mustards Phase 2
42 Angiogenesis Inhibitors Phase 2
43 Antineoplastic Agents, Immunological Phase 2
44
Calcium Nutraceutical Phase 2 7440-70-2 271
45
Pentoxifylline Approved, Investigational Phase 1 6493-05-6 4740
46
Hydroxyurea Approved Phase 1 127-07-1 3657
47 Phosphodiesterase Inhibitors Phase 1
48 Antioxidants Phase 1
49 Vasodilator Agents Phase 1
50 Platelet Aggregation Inhibitors Phase 1
51 Radiation-Protective Agents Phase 1

Interventional clinical trials:

(showing 8, show less)
# Name Status NCT ID Phase Drugs
1 Phase II Prospective Study of Sequential Myeloablative Chemotherapy With Stem Cell Rescue for the Treatment of Selected High Risk CNS Tumors and Recurrent CNS Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Phase II Study of Methotrexate, Mechlorethamine, Vincristine, Prednisone, and Procarbazine (MMOPP) as Primary Therapy in Infants or Young Children With Primitive Neuroectodermal Tumors or High-Grade Astrocytoma Completed NCT00002463 Phase 2 MOPP Regimen;Leucovorin Calcium;Mechlorethamine Hydrochloride;Methotrexate;Prednisone;Procarbazine Hydrochloride;Vincristine Sulfate
3 A Phase I/II Study of Col-3 Administered on a Continuous Daily Oral Schedule in Patients With Recurrent High-Grade Astrocytoma Completed NCT00004147 Phase 1, Phase 2 incyclinide
4 A Phase 2, Investigator Initiated Study to Determine the Safety, Efficacy and CNS Penetration of TH-302 in Recurrent High Grade Astrocytoma Following Bevacizumab Completed NCT01403610 Phase 2 TH-302 preoperative;Placebo;TH-302 (escalating) with bevacizumab 10mg/kg
5 A Phase II Study of Binimetinib in Combination With Encorafenib in Adults With Recurrent BRAF V600-Mutated High-Grade Astrocytoma or Other Primary Brain Tumor Recruiting NCT03973918 Phase 2 Encorafenib;Binimetinib
6 A Phase 2 Investigator Initiated Study to Determine the Efficacy and Safety of TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma Active, not recruiting NCT03032484 Phase 2 Bevacizumab;TVB-2640
7 A PHASE I STUDY OF COMBINED RADIATION RESPONSE MODIFIERS EMPLOYING HYDROXYUREA AND PENTOXIFYLLINE FOR TREATMENT OF GLIOBLASTOMA Completed NCT00019058 Phase 1 chemotherapy;hydroxyurea;pentoxifylline
8 Organoids Derived From Induced-Pluripotent Stem Cells (iPS) From Patients Recruiting NCT03971812

Search NIH Clinical Center for High-Grade Astrocytoma

Genetic Tests for High-Grade Astrocytoma

Anatomical Context for High-Grade Astrocytoma

MalaCards organs/tissues related to High-Grade Astrocytoma:

40
Brain, Spinal Cord, Bone, Breast, Endothelial, Liver, Lung

Publications for High-Grade Astrocytoma

Articles related to High-Grade Astrocytoma:

(showing 302, show less)
# Title Authors PMID Year
1
Development of transient radioresistance during fractionated irradiation in vitro. 61
32344261 2020
2
RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis. 61
32001819 2020
3
Use of High-Dose Chemotherapy in Front-Line Therapy of Infants Aged Less Than 12 Months Treated for Aggressive Brain Tumors. 61
32328470 2020
4
Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma. 61
31760595 2020
5
Textiloma Mimicking a Recurrent High-Grade Astrocytoma: A Case Report. 61
32206542 2020
6
Nocardia farcinica meningitis in a patient with high-grade astrocytoma. 61
32074098 2019
7
Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations. 61
30972500 2019
8
Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy. 61
30624746 2019
9
Usefulness of [11C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma. 61
30996153 2019
10
Regorafenib in patients with recurrent high-grade astrocytoma. 61
30820715 2019
11
Supratentorial high-grade astrocytoma with leptomeningeal spread to the fourth ventricle: a lethal dissemination with dismal prognosis. 61
30604394 2019
12
Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region. 61
30901758 2019
13
Significance of Amphiregulin (AREG) for the Outcome of Low and High Grade Astrocytoma Patients. 61
31031857 2019
14
Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children. 61
30660880 2019
15
Nonmeasurable Speckled Contrast-Enhancing Lesions Appearing During Course of Disease Are Associated With IDH Mutation in High-Grade Astrocytoma Patients. 61
30071292 2018
16
Durable Response to Nivolumab in a Pediatric Patient with Refractory Glioblastoma and Constitutional Biallelic Mismatch Repair Deficiency. 61
30104292 2018
17
Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors. 61
29238007 2018
18
Gene expression microarray analysis reveals prognostic markers of survival in high grade astrocytomas. 61
29781781 2018
19
A Rare Case of Metastases from a High-grade Astrocytoma to the Pleura, Bones, and Liver within Six Months of Diagnosis. 61
30410840 2018
20
MR Imaging Features of Anaplastic Pleomorphic Xanthoastrocytoma Mimicking High-Grade Astrocytoma. 61
29903923 2018
21
Evaluation of high-grade astrocytoma recurrence patterns after radiotherapy in the era of temozolomide: A single institution experience. 61
29760590 2018
22
Cerebellar high-grade astrocytoma with IDH mutations in the elderly: A report of two cases. 61
29635724 2018
23
Vessel Morphologies of the Brain in Cytological Squash Preparations Are Useful for Intraoperative Diagnosis of High-Grade Astrocytomas. 61
29621779 2018
24
Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging. 61
30026674 2018
25
Region-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma. 61
27975172 2018
26
Glioblastoma Multiforme in a Patient with Multiple Myeloma: A Case Report and Literature Review. 61
29616908 2018
27
Long-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma. 61
28791452 2017
28
Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma. 61
27999986 2017
29
A case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades. 61
28185325 2017
30
[Clinical effects of microsurgery in spinal cord anaplastic astrocytoma]. 61
28592077 2017
31
High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients. 61
28339043 2017
32
Gene Expression Profiling of Chemokines and Their Receptors in Low and High Grade Astrocytoma 61
28610419 2017
33
Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas. 61
28513547 2017
34
Distant spread of a supratentorial glioblastoma to the spinal cord. 61
28089418 2017
35
Quantitative Proteomics Reveals Fundamental Regulatory Differences in Oncogenic HRAS and Isocitrate Dehydrogenase (IDH1) Driven Astrocytoma. 61
27834733 2017
36
IDH1 R132H Mutation Is Accompanied with Malignant Progression of Paired Primary-Recurrent Astrocytic Tumours. 61
28928859 2017
37
A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. 61
26984877 2016
38
Relationship Between Cytogenetic Complexity and Peritumoral Edema in High-Grade Astrocytoma. 61
27578512 2016
39
Treatment Outcomes and Prognostic Factors in Adult Astrocytoma: In North East of Iran. 61
27822343 2016
40
Successful Management of Intraoperative Acute Bilateral Pulmonary Embolism in a High Grade Astrocytoma Patient. 61
27578311 2016
41
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma. 61
27460417 2016
42
The role of connexin43-Src interaction in astrocytomas: A molecular puzzle. 61
25711938 2016
43
Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults. 61
26848927 2016
44
A comparison study of (11)C-methionine and (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scans in evaluation of patients with recurrent brain tumors. 61
27095856 2016
45
High-grade glioma in children and adolescents: a single-center experience. 61
26679932 2016
46
Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls. 61
27462365 2016
47
Simultaneous 11C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging of Suspected Primary Brain Tumors. 61
27907162 2016
48
Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging. 61
26002128 2015
49
Nitroproteins in Human Astrocytomas Discovered by Gel Electrophoresis and Tandem Mass Spectrometry. 61
26450359 2015
50
Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma. 61
26351319 2015
51
Anaplastic astrocytoma mimicking herpes simplex encephalitis in 13-year old girl. 61
26272584 2015
52
MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma. 61
26286747 2015
53
Combined therapies of antithrombotics and antioxidants delay in silico brain tumour progression. 61
24562299 2015
54
Radio-chemotherapy improves survival in IDH-mutant, 1p/19q non-codeleted secondary high-grade astrocytoma patients. 61
26033545 2015
55
Prognostic significance of multiple kallikreins in high-grade astrocytoma. 61
26231762 2015
56
Study of the biodistribution of fluorescein in glioma-infiltrated mouse brain and histopathological correlation of intraoperative findings in high-grade gliomas resected under fluorescein fluorescence guidance. 61
25839919 2015
57
High-grade astrocytoma (Glioblastoma Multiforme) in an Atlantic spotted dolphin (Stenella frontalis). 61
25728810 2015
58
Differentiation between Solitary Cerebral Metastasis and Astrocytoma on the Basis of Subventricular Zone Involvement on Magnetic Resonance Imaging. 61
26197398 2015
59
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. 61
25420773 2014
60
Medical management of high-grade astrocytoma: current and emerging therapies. 61
25173143 2014
61
Depressive symptoms and cytokine levels in Serum and Tumor Tissue in patients with an Astrocytoma: a pilot study. 61
24997057 2014
62
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. 61
24705250 2014
63
[Prognostic analyses of intramedullary high grade astrocytomas]. 61
25143162 2014
64
Evaluation of O6-methylguanine-DNA methyltransferase enzyme expression effect on survival of patients with Grade 4 brain astrocytoma. 61
25097625 2014
65
Neuro-oncology: Novel biomarkers for high-grade astrocytoma. 61
24514869 2014
66
Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers. 61
24550271 2014
67
Expression of tissue factor signaling pathway elements correlates with the production of vascular endothelial growth factor and interleukin-8 in human astrocytoma patients. 61
24297570 2014
68
Optimization of high grade glioma cell culture from surgical specimens for use in clinically relevant animal models and 3D immunochemistry. 61
24429465 2014
69
Immunoglobulin genes implicated in glioma risk. 61
25097800 2014
70
Fluorescence-guided surgery and biopsy in gliomas with an exoscope system. 61
24971317 2014
71
Generation of neuronal progenitor cells in response to tumors in the human brain. 61
24170295 2014
72
Seizures as a presenting symptom in neurosurgical patients: a retrospective single-institution analysis. 61
24011499 2013
73
Anaplastic astrocytomas with abundant Rosenthal fibers in elderly patients: a diagnostic pitfall of high-grade gliomas. 61
23438297 2013
74
Exploratory evaluation of MR permeability with 18F-FDG PET mapping in pediatric brain tumors: a report from the Pediatric Brain Tumor Consortium. 61
23801675 2013
75
Astrocytoma development following complete multiple myeloma remission in a 49-year-old patient: A case report. 61
24137217 2013
76
Safety and diagnostic accuracy of neuroendoscopic biopsies: an international multicenter study. 61
23581635 2013
77
Pediatric internuclear ophthalmoplegia. 61
23470988 2013
78
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. 61
23542378 2013
79
Inhibition of formyl peptide receptor in high-grade astrocytoma by CHemotaxis Inhibitory Protein of S. aureus. 61
23322202 2013
80
Plasma levels of transforming growth factor-beta 1 before and after removal of low- and high-grade astrocytomas. 61
23260996 2013
81
Differential expression of the RNA-binding motif protein 3 in human astrocytoma. 61
23673116 2013
82
Integrated analysis of mismatch repair system in malignant astrocytomas. 61
24073290 2013
83
Differentiation of primary central nervous system lymphomas from high grade astrocytomas by qualitative analysis of the signal intensity curves derived from dynamic susceptibility-contrast magnetic resonance imaging. 61
23146301 2012
84
Hypoxic cell waves around necrotic cores in glioblastoma: a biomathematical model and its therapeutic implications. 61
23151957 2012
85
A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. 61
22322885 2012
86
[Diagnostic imaging of high-grade astrocytoma: heterogeneity of clinical manifestation, image characteristics, and histopathological findings]. 61
23037605 2012
87
Outcome of primary childhood central nervous system tumors: results from a single center in Iran. 61
22915472 2012
88
Radiation-induced glioma following CyberKnife® treatment of metastatic renal cell carcinoma: a case report. 61
22943305 2012
89
Neuroimaging findings in the initial phase of development of high grade cortical astrocytomas. 61
21925688 2012
90
Increased immune gene expression and immune cell infiltration in high-grade astrocytoma distinguish long-term from short-term survivors. 61
22802421 2012
91
Differential expression of a novel voltage gated potassium channel--Kv 1.5 in astrocytomas and its impact on prognosis in glioblastoma. 61
21707241 2012
92
Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. 61
22253878 2012
93
Capturing the molecular and biological diversity of high-grade astrocytoma in genetically engineered mouse models. 61
22287481 2012
94
Should we reoperate for recurrent high-grade astrocytoma? 61
21590314 2011
95
Characteristics of tumour vessels in cytological squash smears of astrocytic tumours. 61
21039979 2011
96
Differential dependency of human cancer cells on vascular endothelial growth factor-mediated autocrine growth and survival. 61
21683519 2011
97
Elevated citrate in pediatric astrocytomas with malignant progression. 61
21771868 2011
98
Intracranial metastasis of spinal intramedullary anaplastic astrocytoma. 61
22347337 2011
99
Raman spectroscopic grading of astrocytoma tissues: using soft reference information. 61
21537917 2011
100
Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. 61
21507933 2011
101
A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. 61
21464220 2011
102
Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. 61
21397855 2011
103
Association of invasive breast carcinoma and multicentric high grade astrocytoma: a case report with a review. 61
21528782 2011
104
Can diffusion tensor metrics help in preoperative grading of diffusely infiltrating astrocytomas? A retrospective study of 36 cases. 61
20809287 2011
105
Prognostic significance of expression patterns of EGFR family, p21 and p27 in high-grade astrocytoma. 61
21361082 2010
106
Differential expression of hedgehog signaling components and Snail/E-cadherin in human brain tumors. 61
20878114 2010
107
Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma. 61
20599806 2010
108
Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis. 61
20043190 2010
109
Increased inhibitor of differentiation 4 (id4) expression in glioblastoma: a tissue microarray study. 61
20842217 2010
110
Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas. 61
20388773 2010
111
Intra-operative, real-time, three-dimensional ultrasound assisted positioning of catheters in the microdialysis of glial tumours. 61
20093029 2010
112
A phase II prospective study of sequential myeloablative chemotherapy with hematopoietic stem cell rescue for the treatment of selected high risk and recurrent central nervous system tumors. 61
19768658 2010
113
Comparison of functional outcomes in low- and high-grade astrocytoma rehabilitation inpatients. 61
20068429 2010
114
Status of stereotactic biopsy in children with brain stem masses: insights from a series of 106 patients. 61
20861659 2010
115
Stereotactic biopsy for brainstem tumors in pediatric patients. 61
19784659 2010
116
Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma. 61
19594548 2009
117
Congenital gliosarcoma: detailed clinicopathologic documentation of a rare neoplasm. 61
19883237 2009
118
Bilateral temporal glioma presenting as a paraneoplastic limbic encephalitis with pure cognitive impairment. 61
19590380 2009
119
Absence of AKT1 mutations in glioblastoma. 61
19461960 2009
120
[Diffuse bone marrow metastasis in cerebellar high-grade astrocytoma. A case report]. 61
19263392 2009
121
Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity. 61
19276385 2009
122
Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. 61
19138852 2009
123
Telomerase inhibition induces acute ATM-dependent growth arrest in human astrocytomas. 61
18945545 2009
124
The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma. 61
19331209 2009
125
Analysis of VEGF, Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progression. 61
19473053 2009
126
Atypical intracerebral schwannoma mimicking glial tumor: case report. 61
19263360 2009
127
Possible involvement of brain tumour stem cells in the emergence of a fast-growing malignant meningioma after surgical resection and radiotherapy of high-grade astrocytoma: case report and preliminary laboratory investigation. 61
19215696 2009
128
Glioblastoma multiforme in the posterior cranial fossa in a patient with neurofibromatosis type I. 61
20029672 2009
129
Radioguided surgery in brain tumors with thallium-201. 61
19033782 2008
130
Preoperative grading of presumptive low-grade astrocytomas on MR imaging: diagnostic value of minimum apparent diffusion coefficient. 61
18719036 2008
131
Canine ocular gliomas: a retrospective study. 61
19046275 2008
132
Dynamic contrast-enhanced derived cerebral blood volume correlates better with leak correction than with no correction for vascular endothelial growth factor, microvascular density, and grading of astrocytoma. 61
19204461 2008
133
IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK. 61
18952587 2008
134
Low level of microsatellite instability in paediatric malignant astrocytomas. 61
18053027 2008
135
Protein- and DNA-based active immunotherapy targeting interleukin-13 receptor alpha2. 61
18976118 2008
136
Duodenal adenocarcinoma and Mut Y human homologue-associated polyposis. 61
18787472 2008
137
Phase II study of metronomic chemotherapy with thalidomide, carboplatin-vincristine-fluvastatin in the treatment of brain stem tumors in children. 61
18760193 2008
138
Prognostic value of perfusion MR imaging of high-grade astrocytomas: long-term follow-up study. 61
18556364 2008
139
Cerebral phaeohyphomycosis mimics high-grade astrocytoma. 61
18614370 2008
140
Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease. 61
18414790 2008
141
Hemiparkinsonism secondary to an infiltrative astrocytoma. 61
18617854 2008
142
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. 61
18451155 2008
143
Tyrosine kinase expression in pediatric high grade astrocytoma. 61
18193393 2008
144
Surgical treatment of intramedullary spinal cord tumors: prognosis and complications. 61
17909556 2008
145
Decreased levels of interleukin-10 and transforming growth factor-beta 2 in cerebrospinal fluid of patients with high grade astrocytoma. 61
17848206 2008
146
NAT2*7 allele is a potential risk factor for adult brain tumors in Taiwanese population. 61
18349284 2008
147
Unusual case of leptomeningeal dissemination of a diffuse pontine high-grade astrocytoma in a child. 61
18334845 2008
148
High-grade astrocytoma in very young children. 61
17554787 2007
149
Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. 61
18093951 2007
150
Diagnosis and treatment of high-grade astrocytoma. 61
17964028 2007
151
Evaluation of invasiveness of astrocytoma using 1H-magnetic resonance spectroscopy: correlation with expression of matrix metalloproteinase-2. 61
17763847 2007
152
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group. 61
17705175 2007
153
B-FABP-expressing radial glial cells: the malignant glioma cell of origin? 61
17898869 2007
154
Elderly and poor prognosis patients with high grade glioma: hypofractionated radiotherapy. 61
17612282 2007
155
Salvage chemotherapy in progressive high-grade astrocytoma. 61
17549281 2007
156
Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic marker. 61
17151933 2007
157
A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue. 61
17260000 2007
158
Geminin: a good prognostic factor in high-grade astrocytic brain tumors. 61
17262828 2007
159
Proteomic identification of biomarkers in the cerebrospinal fluid (CSF) of astrocytoma patients. 61
17269713 2007
160
Spinal cord high grade astrocytoma. 61
17616049 2007
161
Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis. 61
17634619 2007
162
Malignant transformation of high-grade astrocytoma associated with neurocysticercosis in a patient with Turcot syndrome. 61
17138070 2007
163
Expression of autocrine motility factor mRNA is a poor prognostic factor in high-grade astrocytoma. 61
16930331 2006
164
Pooled analysis of two case-control studies on use of cellular and cordless telephones and the risk for malignant brain tumours diagnosed in 1997-2003. 61
16541280 2006
165
High-grade astrocytoma treated concomitantly with estramustine and radiotherapy. 61
16598426 2006
166
Tectal plate lesions in children. 61
16776370 2006
167
Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas. 61
16614947 2006
168
Diagnosis and treatment of recurrent high-grade astrocytoma. 61
16525182 2006
169
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. 61
16530701 2006
170
Case-control study of the association between the use of cellular and cordless telephones and malignant brain tumors diagnosed during 2000-2003. 61
16023098 2006
171
Molecular cytogenetic stratification of recurrent oligodendrogliomas: utility of interphase fluorescence in situ hybridization (I-FISH). 61
17089917 2006
172
Stable incidence of childhood and adult glioma in The Netherlands, 1989-2003. 61
16644569 2006
173
Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933. 61
16315242 2005
174
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. 61
15958561 2005
175
Maintenance of fertility following treatment with temozolomide for a high grade astrocytoma. 61
15981111 2005
176
[A case of high grade astrocytoma arising in the hand area of precentral gyrus]. 61
16026048 2005
177
Proton magnetic resonance spectroscopy of brain tumors correlated with pathology. 61
15691725 2005
178
Molecular mechanisms in gliomagenesis. 61
16095998 2005
179
Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma. 61
15804144 2005
180
[Microsurgical technique of brain glioma---a report of 183 cases]. 61
15522181 2004
181
Altered molecular pathways in gliomas: an overview of clinically relevant issues. 61
15497113 2004
182
Analysis of interleukin-13 receptor alpha2 expression in human pediatric brain tumors. 61
15329913 2004
183
Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance. 61
15088099 2004
184
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. 61
15172069 2004
185
Early neuro-otologic effects of three-dimensional irradiation in children with primary brain tumors. 61
15001264 2004
186
Pre-irradiation chemotherapy for newly diagnosed high grade astrocytoma. 61
15154655 2004
187
Intractable vomiting as an early clinical symptom of cerebrospinal fluid seeding to the fourth ventricle in patients with high-grade astrocytoma. 61
15015789 2004
188
Heterogeneity in the expression of markers for drug resistance in brain tumors. 61
14986930 2004
189
Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist. 61
15047924 2004
190
Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines. 61
14647148 2003
191
Molecular targeting with recombinant cytotoxins of interleukin-13 receptor alpha2-expressing glioma. 61
12952292 2003
192
The glycine peak in brain diseases. 61
12631515 2003
193
Cerebral high-grade astrocytoma (glioblastoma) in a cat. 61
14567516 2003
194
A preliminary survey of central nervous system tumors in Tema, Ghana. 61
14529231 2003
195
Combined modality therapy for poorly differentiated gliomas of the posterior fossa in children: a Children's Cancer Group report. 61
12814254 2003
196
Grade II astrocytomas are subgrouped by chromosome aberrations. 61
12660025 2003
197
Malignant transformation of a chiasmatic pilocytic astrocytoma in a patient with diencephalic syndrome. 61
12612823 2003
198
Genetic alterations of human brain tumors as molecular prognostic factors. 61
12722932 2003
199
Signaling pathways regulating gliomagenesis. 61
12558076 2003
200
Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis. 61
12622454 2003
201
Blood-brain barrier breakdown in septic encephalopathy and brain tumours. 61
12162731 2002
202
Aberrant nuclear factor-kappaB activity and its participation in the growth of human malignant astrocytoma. 61
12005399 2002
203
Lysosomal enzymes, cathepsins in brain tumour invasion. 61
12160137 2002
204
Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. 61
12086874 2002
205
An integrated approach utilizing artificial neural networks and SELDI mass spectrometry for the classification of human tumours and rapid identification of potential biomarkers. 61
11934738 2002
206
Intramedullary spinal cord astrocytoma in adults: postoperative outcome. 61
11451207 2001
207
Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial. 61
11208845 2001
208
Superselective intra-arterial carboplatin for treatment of intracranial neoplasms: experience in 100 procedures. 61
11386412 2001
209
Molecular genetics of radiographically defined de novo glioblastoma multiforme. 61
11123721 2000
210
FDG-PET as a prognostic factor in high-grade astrocytoma. 61
11206011 2000
211
Neurosarcoidosis: evaluation with MRI. 61
11104966 2000
212
Acquired cerebral arteriovenous malformation induced by an anaplastic astrocytoma: an interesting case. 61
10935219 2000
213
Multiple myeloma showing increased accumulation of Tc-99m hexamethylpropylene amine oxime on brain SPECT. 61
10836712 2000
214
Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss. 61
10839259 2000
215
Therapy for patients with high grade astrocytoma using intraarterial chemotherapy and radiation therapy. 61
10820358 2000
216
Lack of efficacy of 9-aminocamptothecin in adults with newly diagnosed glioblastoma multiforme and recurrent high-grade astrocytoma. NABTT CNS Consortium. 61
11302251 2000
217
A new semiquantitative method for comparing brain tumor uptake of Tc-99m sestamibi and TI-201. 61
10551470 1999
218
[Role of magnetic resonance imaging in the diagnosis of neurosarcoidosis]. 61
10550389 1999
219
Classification of small cell lung cancer and pulmonary carcinoid by gene expression profiles. 61
10537285 1999
220
The effects of sequential versus concurrent chemotherapy and radiotherapy on survival and toxicity in patients with newly diagnosed high-grade astrocytoma. 61
10348282 1999
221
Parental age as a risk factor of childhood leukemia and brain cancer in offspring. 61
10230837 1999
222
Identification of a glioblastoma-associated tenascin-C isoform by a high affinity recombinant antibody. 61
10329587 1999
223
Clinical and radiographic response in three children with recurrent malignant cerebral tumors with high-dose tamoxifen. 61
10326223 1999
224
Pre-irradiation carboplatin and etoposide and accelerated hyperfractionated radiation therapy in patients with high-grade astrocytomas: a phase II study. 61
10386714 1999
225
Clinico-morphological pattern of intracranial tumors in children. 61
10531783 1999
226
Age-dependent rate of anaplastic transformation in low-grade astrocytoma. 61
10078745 1999
227
Modifying radical radiotherapy in high grade gliomas; shortening the treatment time through acceleration. 61
10030251 1999
228
[Classification and grading of gliomas and meningiomas]. 61
9861648 1998
229
Multi-drug versus single agent chemotherapy for high grade astrocytoma; results of a meta-analysis. 61
9891542 1998
230
Platinum analogues in the treatment of recurrent high grade astrocytoma. 61
9861194 1998
231
Malignant cerebellar astrocytomas in childhood. Experience with four cases. 61
9840375 1998
232
A Phase II clinical trial of idarubicin administered to children with relapsed brain tumors. 61
9708950 1998
233
Towards a method for automated classification of 1H MRS spectra from brain tumours. 61
9719572 1998
234
Meta-analytic re-evaluation of misonidazole in the treatment of high grade astrocytoma. 61
9677447 1998
235
Genetic sub-types of human malignant astrocytoma correlate with survival. 61
9583731 1998
236
Human astrocytoma cells are capable of producing macrophage inflammatory protein-1beta. 61
9525834 1998
237
Treatment of recurrent high grade astrocytoma; results of a systematic review of 1,415 patients. 61
9615807 1998
238
Treatment of high-grade spinal cord astrocytoma of childhood with "8-in-1" chemotherapy and radiotherapy: a pilot study of CCG-945. Children's Cancer Group. 61
9452226 1998
239
Phase II study of acivicin in patients with recurrent high grade astrocytoma. 61
18644287 1998
240
Spinal metastases of a high grade astrocytoma visualized with FDG-PET. 61
9408658 1997
241
Tumor targeting potential of the monoclonal antibody BC-1 against oncofetal fibronectin in nude mice bearing human tumor implants. 61
9406686 1997
242
Accumulation of genetic changes is associated with poor prognosis in grade II astrocytomas. 61
9403731 1997
243
AgNOR expression in CNS neoplasms. 61
9444862 1997
244
Phase II trial of merbarone in patients with malignant brain tumors. 61
9468039 1997
245
Phase II study of continuous infusion carmustine and cisplatin followed by cranial irradiation in adults with newly diagnosed high-grade astrocytoma. 61
9215830 1997
246
Randomized trial of radiation therapy (RT) plus dibromodulcitol (DBD) versus RT plus BCNU in high grade astrocytoma. 61
9195495 1997
247
Liver and lung metastases of high-grade astrocytoma showing abnormal Tc-99m MDP localization. 61
9227886 1997
248
Somatostatin receptor scintigraphy of non-neuroendocrine malignancies with 111In-pentetreotide. 61
9179200 1997
249
Contemporary issues in the management of childhood brain tumors. 61
9146994 1997
250
Corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma. 61
9212000 1997
251
Malignant astrocytoma-derived region of common amplification in chromosomal band 17p12 is frequently amplified in high-grade osteosarcomas. 61
9087567 1997
252
Late sequelae of treated pleomorphic xanthoastrocytoma: malignant brain stem astrocytoma occurring 15 years after radiation therapy. 61
9049863 1997
253
Intraspinal high-grade astrocytoma in a child--rationale for chemotherapy and more intensive radiotherapy? 61
9105749 1997
254
Pion radiation for high grade astrocytoma: results of a randomized study. 61
9112443 1997
255
Receptor scintigraphy of non-neuroendocrine cancers with In-111 pentetreotide. 61
9085140 1997
256
Thalamic gliomas: a clinicopathologic analysis of 20 cases with reference to patient age. 61
9202774 1997
257
Hypofractionated stereotactic radiotherapy in the management of recurrent glioma. 61
9069312 1997
258
Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma. 61
8971168 1996
259
Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma. 61
8824514 1996
260
Characterization of double minute chromosomes' DNA content in a human high grade astrocytoma cell line by using comparative genomic hybridization and fluorescence in situ hybridization. 61
8707292 1996
261
Immunohistochemical detection of CDKN2, retinoblastoma and p53 gene products in primary astrocytic tumors. 61
21544442 1996
262
Noninvasive perfusion imaging of human brain tumors with EPISTAR. 61
8798035 1996
263
Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma. 61
7614486 1995
264
Molecular analysis at the NF1 locus in astrocytic brain tumors. 61
8625164 1995
265
Potential uses of interferon alpha 2 as adjuvant therapy in cancer. 61
7552628 1995
266
[The value of scintigraphic imaging with 99mTc-MIBI for the diagnosis of gliomas]. 61
9455354 1995
267
Pineal region tumours treated with interstitial brachytherapy with low activity sources (192-iridium). 61
8748823 1995
268
Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. 61
7799011 1995
269
Stereotactic biopsy of 100 intracerebral lesions at Sir Charles Gairdner Hospital. 61
7892040 1994
270
Tenascin in cerebrospinal fluid is a useful biomarker for the diagnosis of brain tumour. 61
7523604 1994
271
Induction of high grade astrocytoma (HGA) by protons: molecular mechanisms and RBE considerations. 61
11539960 1994
272
Prognostic scoring in adult astrocytic tumors using patient age, histopathological grade, and DNA histogram type. 61
8169628 1994
273
201Tl single photon emission tomography in the evaluation of residual and recurrent astrocytoma. 61
8190401 1994
274
Survival in patients with recurrent glioma as a measure of treatment efficacy: prognostic factors following nitrosourea chemotherapy. 61
7880611 1994
275
Pre-irradiation chemotherapy in children with high-grade astrocytoma: tumor response to two cycles of the '8-drugs-in-1-day' regimen. A Childrens Cancer Group study, CCG-945. 61
7699420 1994
276
Tectal plate gliomas. Part I: Microsurgery of the tectal plate gliomas. 61
8042559 1994
277
99Tcm-HMPAO brain SPECT in the evaluation of prognosis after surgical resection of astrocytoma. Comparison with other noninvasive imaging techniques (CT, MRI and 201Tl SPECT). 61
8295760 1993
278
Relationship between tissue polyamine levels and malignancy in primary brain tumors. 61
8455761 1993
279
[Brainstem glioma with supratentorial meningeal dissemination--a case report]. 61
1285996 1992
280
Molecular characterization of areas with low grade tumor or satellitosis in human malignant astrocytomas. 61
1311634 1992
281
Immunocytochemical and ultrastructural studies of eosinophilic granular bodies in astrocytic tumors. 61
1575017 1992
282
Increase in omega 3 (peripheral-type benzodiazepine) binding site densities in different types of human brain tumours. A quantitative autoradiography study. 61
1336303 1992
283
Modern therapeutic approach for high grade astrocytoma: intracranial Ir-192 brachytherapy. 61
1661321 1991
284
[Acute signs and symptoms of toxicity due to the BOPP regimen (BCNU, vincristine, procarbazine, cisplatin) during treatment of high-grade astrocytoma]. 61
1806994 1991
285
Recombinant interferon beta: a phase I-II trial in children with recurrent brain tumors. 61
2016620 1991
286
Carboplatin in childhood brain tumors. A Children's Cancer Study Group Phase II trial. 61
2249186 1990
287
Delineation of gliomas with magnetic resonance imaging using Gd-DTPA in comparison with computed tomography and positron emission tomography. 61
2261284 1990
288
High-dose carboplatin in combination with etoposide (JET regimen) for childhood brain tumors. 61
2173440 1990
289
Immediate reconstruction of mandibular defects with revascularized iliac bone grafts after radical surgery for osteosarcoma. 61
2094848 1990
290
The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group. 61
2550594 1989
291
Specific localization of thallium 201 in human high-grade astrocytoma by microautoradiography. 61
2786750 1989
292
Radiotherapy and L-triiodothyronine in the treatment of high-grade astrocytoma. 61
2845197 1988
293
Transforming growth factors in urine from patients with primary brain tumors. 61
3258633 1988
294
Thallium-201 tumor/cardiac ratio estimation of residual astrocytoma. 61
2833588 1988
295
Fine needle aspiration cytology of a cerebral ganglioglioma. Report of a case. 61
3287820 1988
296
Extensive surgical excision of large hemispheric "malignant" astrocytoma in a 6-week-old infant. 61
2825995 1987
297
Radiation treatment with twice a day fractionation versus conventional fractionation in high grade astrocytoma. A retrospective study. 61
3446243 1987
298
Products of cells cultured from gliomas. V. Cytology and morphometry of two cell types cultured from glioma. 61
3025505 1987
299
Peripheral benzodiazepine binding sites in human gliomas evaluated with positron emission tomography. 61
2856547 1986
300
[Malignancy grading of glial tumors. I. Astrocytomas]. 61
3010600 1985
301
High grade astrocytoma with spontaneous meningeal and cranial invasion. 61
6298651 1982
302
Radiation sensitivity of cultured human glioblastoma cells. 61
197567 1977

Variations for High-Grade Astrocytoma

Expression for High-Grade Astrocytoma

Search GEO for disease gene expression data for High-Grade Astrocytoma.

Pathways for High-Grade Astrocytoma

Pathways related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Super pathways Score Top Affiliating Genes
1 10.48 KLK9 KLK7 KLK6

GO Terms for High-Grade Astrocytoma

Cellular components related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 TGFB2 PTEN KLK9 KLK7 KLK6 IDH1
2 secretory granule GO:0030141 9.13 KLK9 KLK7 KLK6

Biological processes related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

(showing 11, show less)
# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor signaling pathway GO:0007179 9.61 TGFB2 PARP1 ACVR1
2 outflow tract septum morphogenesis GO:0003148 9.49 TGFB2 ACVR1
3 protein autoprocessing GO:0016540 9.48 PARP1 KLK6
4 endocardial cushion morphogenesis GO:0003203 9.46 TGFB2 ACVR1
5 learning or memory GO:0007611 9.43 PTEN GPI AMFR
6 pathway-restricted SMAD protein phosphorylation GO:0060389 9.4 TGFB2 ACVR1
7 synapse maturation GO:0060074 9.37 PTEN NFIA
8 atrioventricular valve morphogenesis GO:0003181 9.32 TGFB2 ACVR1
9 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.16 TGFB2 ACVR1
10 atrial septum primum morphogenesis GO:0003289 8.96 TGFB2 ACVR1
11 endocardial cushion fusion GO:0003274 8.62 TGFB2 ACVR1

Molecular functions related to High-Grade Astrocytoma according to GeneCards Suite gene sharing:

(showing 5, show less)
# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.43 KLK9 KLK7 KLK6
2 serine-type peptidase activity GO:0008236 9.33 KLK9 KLK7 KLK6
3 protein tyrosine kinase binding GO:1990782 9.32 PTEN ACVR1
4 ubiquitin-specific protease binding GO:1990381 8.96 PTEN AMFR
5 SMAD binding GO:0046332 8.8 PARP1 FLNA ACVR1

Sources for High-Grade Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
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72 UMLS via Orphanet
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