MCID: HGH031
MIFTS: 18

High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

MalaCards integrated aliases for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement:

Name: High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Orphanet 58 ORPHA480541

Summaries for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

MalaCards based summary : High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement is related to diffuse large b-cell lymphoma of the central nervous system and suppressor of tumorigenicity 3. An important gene associated with High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement is BCL2 (BCL2 Apoptosis Regulator), and among its related pathways/superpathways are Cytokine Signaling in Immune system and JAK-STAT signaling pathway. Related phenotypes are adipose tissue and muscle

Related Diseases for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Diseases related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 diffuse large b-cell lymphoma of the central nervous system 10.0 MYC BCL2
2 suppressor of tumorigenicity 3 10.0 MYC BCL2
3 alk-negative anaplastic large cell lymphoma 9.9 MYC BCL2
4 inflammatory myofibroblastic tumor 9.9 MYC BCL2
5 lymphoma aids related 9.9 MYC BCL6
6 paranasal sinus lymphoma 9.9 MYC BCL6
7 appendix lymphoma 9.9 MYC BCL6
8 plasmablastic lymphoma 9.8 MYC BCL6
9 pediatric lymphoma 9.8 MYC BCL6
10 adult lymphoma 9.8 MYC BCL6
11 li-fraumeni syndrome 9.8 MYC BCL2
12 central nervous system lymphoma 9.8 MYC BCL6
13 central nervous system hematologic cancer 9.8 MYC BCL6
14 nodal marginal zone b-cell lymphoma 9.8 BCL6 BCL2
15 marginal zone b-cell lymphoma 9.8 BCL6 BCL2
16 follicular lymphoma 1 9.8 BCL6 BCL2
17 lymphosarcoma 9.8 BCL6 BCL2
18 mature t-cell and nk-cell lymphoma 9.8 MYC BCL6
19 human herpesvirus 8 9.8 BCL6 BCL2
20 lymphoblastic lymphoma 9.8 MYC BCL6
21 primary central nervous system lymphoma 9.8 BCL6 BCL2
22 mature b-cell neoplasm 9.8 MYC BCL6
23 nervous system cancer 9.8 MYC BCL2
24 intraocular lymphoma 9.8 BCL6 BCL2
25 sezary's disease 9.8 MYC BCL6
26 primary mediastinal b-cell lymphoma 9.7 BCL6 BCL2
27 acquired immunodeficiency syndrome 9.7 MYC BCL6
28 t-cell lymphoblastic leukemia/lymphoma 9.7 MYC BCL2
29 lymphatic system cancer 9.7 MYC BCL6
30 lymphoma, hodgkin, classic 9.7 BCL6 BCL2
31 lymphatic system disease 9.7 MYC BCL6
32 breast adenocarcinoma 9.7 MYC BCL2
33 b-cell lymphoma 9.5 MYC BCL6 BCL2
34 lymphoma 9.5 MYC BCL6 BCL2
35 intravascular large b-cell lymphoma 9.5 MYC BCL6 BCL2
36 reticulosarcoma 9.5 MYC BCL6 BCL2
37 diffuse large b-cell lymphoma 9.5 MYC BCL6 BCL2
38 lymphoma, mucosa-associated lymphoid type 9.5 MYC BCL6 BCL2
39 follicular lymphoma 9.5 MYC BCL6 BCL2
40 mantle cell lymphoma 9.5 MYC BCL6 BCL2
41 burkitt lymphoma 9.5 MYC BCL6 BCL2
42 wilms tumor 1 9.5 MYC BCL6 BCL2
43 lymphoma, non-hodgkin, familial 9.5 MYC BCL6 BCL2
44 leukemia, acute lymphoblastic 9.5 MYC BCL6 BCL2
45 autosomal dominant non-syndromic intellectual disability 9.5 MYC BCL6
46 acute promyelocytic leukemia 9.5 MYC BCL6 BCL2
47 leukemia, chronic lymphocytic 9.5 MYC BCL6 BCL2

Graphical network of the top 20 diseases related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement:



Diseases related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement

Symptoms & Phenotypes for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

MGI Mouse Phenotypes related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.13 BCL2 BCL6 MYC
2 muscle MP:0005369 8.8 BCL2 BCL6 MYC

Drugs & Therapeutics for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Search Clinical Trials , NIH Clinical Center for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement

Genetic Tests for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Anatomical Context for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Publications for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Variations for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Expression for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Search GEO for disease gene expression data for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement.

Pathways for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Pathways related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.86 MYC BCL6 BCL2
2
Show member pathways
12.01 MYC BCL2
3
Show member pathways
12 MYC BCL6
4
Show member pathways
11.97 MYC BCL2
5 11.87 MYC BCL6
6 11.85 MYC BCL2
7
Show member pathways
11.85 MYC BCL6 BCL2
8 11.75 MYC BCL2
9
Show member pathways
11.68 MYC BCL2
10 11.67 BCL6 BCL2
11
Show member pathways
11.52 MYC BCL2
12 11.49 MYC BCL2
13 11.4 MYC BCL2
14
Show member pathways
11.32 MYC BCL2
15 11.26 MYC BCL2
16 11.19 MYC BCL6 BCL2
17 11.12 MYC BCL2
18 11.08 MYC BCL2
19
Show member pathways
11.05 MYC BCL2
20 10.86 MYC BCL6 BCL2
21 10.82 MYC BCL2
22
Show member pathways
10.66 MYC BCL2

GO Terms for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Biological processes related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.54 MYC BCL6 BCL2
2 cellular response to DNA damage stimulus GO:0006974 9.5 MYC BCL6 BCL2
3 cellular response to hypoxia GO:0071456 9.48 MYC BCL2
4 negative regulation of cell growth GO:0030308 9.46 BCL6 BCL2
5 cell morphogenesis GO:0000902 9.43 BCL6 BCL2
6 B cell differentiation GO:0030183 9.4 BCL6 BCL2
7 positive regulation of B cell proliferation GO:0030890 9.26 BCL6 BCL2
8 branching involved in ureteric bud morphogenesis GO:0001658 9.16 MYC BCL2
9 response to gamma radiation GO:0010332 8.96 MYC BCL2
10 cytokine-mediated signaling pathway GO:0019221 8.8 MYC BCL6 BCL2

Molecular functions related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 repressing transcription factor binding GO:0070491 8.62 MYC BCL2

Sources for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....