MCID: HGH031
MIFTS: 22

High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

MalaCards integrated aliases for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement:

Name: High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement 59

Classifications:



External Ids:

Orphanet 59 ORPHA480541

Summaries for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

MalaCards based summary : High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement is related to diffuse large b-cell lymphoma and primary effusion lymphoma. An important gene associated with High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement is BCL6 (BCL6, Transcription Repressor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Notch signaling pathway (KEGG). Affiliated tissues include b cells and bone, and related phenotype is muscle.

Related Diseases for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Diseases related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 diffuse large b-cell lymphoma 10.0 BCL6 MYC
2 primary effusion lymphoma 10.0 BCL6 MYC
3 plasmablastic lymphoma 10.0 BCL6 MYC
4 lymphatic system cancer 9.9 BCL6 MYC
5 mature b-cell neoplasm 9.9 BCL6 MYC
6 diffuse large b-cell lymphoma of the central nervous system 9.9 BCL2 MYC
7 leukocyte disease 9.9 BCL6 MYC
8 chronic venous leg ulcers 9.9 BCL2 MYC
9 acquired immunodeficiency syndrome 9.9 BCL6 MYC
10 suppressor of tumorigenicity 3 9.9 BCL2 MYC
11 nodal marginal zone b-cell lymphoma 9.9 BCL2 BCL6
12 marginal zone b-cell lymphoma 9.9 BCL2 BCL6
13 intestinal disease 9.9 BCL6 MYC
14 follicular lymphoma 1 9.9 BCL2 BCL6
15 alk-negative anaplastic large cell lymphoma 9.9 BCL2 MYC
16 intravascular large b-cell lymphoma 9.9 BCL2 BCL6
17 primary central nervous system lymphoma 9.9 BCL2 BCL6
18 human herpesvirus 8 9.9 BCL2 BCL6
19 autoimmune lymphoproliferative syndrome, type v 9.9 BCL2 BCL6
20 gastric lymphoma 9.8 BCL2 BCL6
21 lymphoma, mucosa-associated lymphoid type 9.8 BCL2 BCL6
22 lymphocytic leukemia 9.8 BCL2 MYC
23 adamantinoma of long bones 9.8 BCL2 MYC
24 hematologic cancer 9.8 BCL6 MYC
25 lymphoma 9.7 BCL2 BCL6 MYC
26 primary mediastinal large b-cell lymphoma 9.7 BCL2 BCL6 MYC
27 follicular lymphoma 9.7 BCL2 BCL6 MYC
28 mantle cell lymphoma 9.7 BCL2 BCL6 MYC
29 b-cell lymphomas 9.7 BCL2 BCL6 MYC
30 burkitt lymphoma 9.7 BCL2 BCL6 MYC
31 lymphoma, non-hodgkin, familial 9.7 BCL2 BCL6 MYC

Graphical network of the top 20 diseases related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement:



Diseases related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement

Symptoms & Phenotypes for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

MGI Mouse Phenotypes related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.8 BCL2 BCL6 MYC

Drugs & Therapeutics for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Search Clinical Trials , NIH Clinical Center for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement

Genetic Tests for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Anatomical Context for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

MalaCards organs/tissues related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement:

41
B Cells, Bone

Publications for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Variations for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Expression for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Search GEO for disease gene expression data for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement.

Pathways for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Pathways related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.86 BCL2 BCL6 MYC
2
Show member pathways
12.04 BCL2 BCL6 MYC
3
Show member pathways
11.99 BCL6 MYC
4
Show member pathways
11.98 BCL2 MYC
5 11.91 BCL2 MYC
6 11.87 BCL6 MYC
7 11.85 BCL2 MYC
8
Show member pathways
11.81 BCL2 MYC
9 11.75 BCL2 MYC
10 11.75 BCL2 MYC
11
Show member pathways
11.68 BCL2 MYC
12 11.67 BCL2 BCL6
13
Show member pathways
11.52 BCL2 MYC
14 11.49 BCL2 MYC
15 11.4 BCL2 MYC
16
Show member pathways
11.32 BCL2 MYC
17 11.26 BCL2 MYC
18 11.19 BCL2 BCL6 MYC
19 11.12 BCL2 MYC
20
Show member pathways
11.08 BCL2 MYC
21 11.05 BCL2 MYC
22 10.86 BCL2 BCL6 MYC
23 10.82 BCL2 MYC
25
Show member pathways
10.5 BCL2 MYC

GO Terms for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

Biological processes related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.61 BCL2 BCL6 MYC
2 regulation of gene expression GO:0010468 9.52 BCL2 MYC
3 cellular response to hypoxia GO:0071456 9.51 BCL2 MYC
4 negative regulation of cell growth GO:0030308 9.49 BCL2 BCL6
5 B cell differentiation GO:0030183 9.48 BCL2 BCL6
6 cell morphogenesis GO:0000902 9.46 BCL2 BCL6
7 cellular response to DNA damage stimulus GO:0006974 9.43 BCL2 BCL6 MYC
8 branching involved in ureteric bud morphogenesis GO:0001658 9.4 BCL2 MYC
9 ovarian follicle development GO:0001541 9.37 BCL2 MYC
10 positive regulation of B cell proliferation GO:0030890 9.32 BCL2 BCL6
11 response to gamma radiation GO:0010332 9.16 BCL2 MYC
12 positive regulation of smooth muscle cell migration GO:0014911 8.96 BCL2 MYC
13 cytokine-mediated signaling pathway GO:0019221 8.8 BCL2 BCL6 MYC

Molecular functions related to High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6 Rearrangement according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 8.96 BCL6 MYC
2 sequence-specific DNA binding GO:0043565 8.8 BCL2 BCL6 MYC

Sources for High Grade B-Cell Lymphoma with Myc and/ or Bcl2 and/or Bcl6...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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