MCID: HGH001
MIFTS: 26

High Pressure Neurological Syndrome

Categories: Neuronal diseases

Aliases & Classifications for High Pressure Neurological Syndrome

MalaCards integrated aliases for High Pressure Neurological Syndrome:

Name: High Pressure Neurological Syndrome 12 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3230
MeSH 45 D006610
UMLS 74 C0019537

Summaries for High Pressure Neurological Syndrome

MalaCards based summary : High Pressure Neurological Syndrome is related to ocular dominance and epilepsy, and has symptoms including hyperexplexia An important gene associated with High Pressure Neurological Syndrome is PGLYRP3 (Peptidoglycan Recognition Protein 3), and among its related pathways/superpathways are CREB Pathway and Circadian entrainment. Affiliated tissues include brain.

Related Diseases for High Pressure Neurological Syndrome

Diseases related to High Pressure Neurological Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ocular dominance 9.8 GRIN1 GRIN2A
2 epilepsy 9.8
3 benign epilepsy with centrotemporal spikes 9.7 GRIN1 GRIN2A

Symptoms & Phenotypes for High Pressure Neurological Syndrome

UMLS symptoms related to High Pressure Neurological Syndrome:


hyperexplexia

Drugs & Therapeutics for High Pressure Neurological Syndrome

Search Clinical Trials , NIH Clinical Center for High Pressure Neurological Syndrome

Cochrane evidence based reviews: high pressure neurological syndrome

Genetic Tests for High Pressure Neurological Syndrome

Anatomical Context for High Pressure Neurological Syndrome

MalaCards organs/tissues related to High Pressure Neurological Syndrome:

42
Brain

Publications for High Pressure Neurological Syndrome

Articles related to High Pressure Neurological Syndrome:

(show all 34)
# Title Authors Year
1
Acute combined pressure and temperature exposures on a shallow-water crustacean: novel insights into the stress response and high pressure neurological syndrome. ( 25433335 )
2015
2
Extremely deep recreational dives: the risk for carbon dioxide (CO(2)) retention and high pressure neurological syndrome (HPNS). ( 22669812 )
2012
3
Early morphological findings in experimental high pressure neurological syndrome. ( 9495642 )
1997
4
Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome. ( 7912632 )
1994
5
High-pressure neurological syndrome (HPNS). ( 7941956 )
1994
6
Effects of elevated pressures of inert gases on cytosolic free Ca2+ of cultured human neuroblastoma cells stimulated with carbachol: relevance to high pressure neurological syndrome. ( 8149411 )
1994
7
The orally active NMDA receptor antagonist CGP 39551 ameliorates the high pressure neurological syndrome in Papio anubis. ( 7902190 )
1993
8
Interactions of the beta carboline abecarnil with the high pressure neurological syndrome in a primate model. ( 1365651 )
1992
9
Brain nuclei and neurotransmitters involved in the regulation of the high pressure neurological syndrome in the rat. ( 1686303 )
1991
10
The effects of the competitive NMDA receptor antagonist CPP on the high pressure neurological syndrome in a primate model. ( 1833661 )
1991
11
The high pressure neurological syndrome in genetically epilepsy prone rats: protective effect of 2-amino-7-phosphono heptanoate. ( 2029931 )
1991
12
Effect of NMDA and 2-amino-7-phosphonoheptanoate focal injection into the ventrolateral thalamic nucleus on the high pressure neurological syndrome in the rat. ( 2159822 )
1990
13
The effects of MK801 on the high pressure neurological syndrome in the baboon (Papio anubis). ( 2255385 )
1990
14
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats. ( 2556289 )
1989
15
The effects of kynurenic acid, quinolinic acid and other metabolites of tryptophan on the development of the high pressure neurological syndrome in the rat. ( 2927579 )
1989
16
Investigations into the origin of the high pressure neurological syndrome: the interaction between pressure, strychnine and 1,2-propandiols in the mouse. ( 3207974 )
1988
17
The effect of two novel dipeptide antagonists of excitatory amino acid neurotransmission on the high pressure neurological syndrome in the rat. ( 3040442 )
1987
18
Gamma-aminobutyric acid and the high pressure neurological syndrome. ( 3090469 )
1986
19
Effect of excitatory amino acid antagonists on the high pressure neurological syndrome in rats. ( 6096158 )
1984
20
Mechanistic studies on the high pressure neurological syndrome. ( 6142478 )
1984
21
The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( 6148724 )
1984
22
2-Amino-phosphonoheptanoic acid protects against the high pressure neurological syndrome. ( 6406239 )
1983
23
Interactions of gamma-aminobutyric acid and noradrenaline in the high pressure neurological syndrome. ( 6652352 )
1983
24
Non-anesthetic steroids ameliorate the high pressure neurological syndrome in rats. ( 6843778 )
1983
25
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome. ( 6286024 )
1982
26
The benzodiazepine antagonist, Ro 15-1788, prevents the effects of flurazepam on the high pressure neurological syndrome. ( 6815548 )
1982
27
Brain monoamines and the high pressure neurological syndrome. ( 6449674 )
1980
28
Comparative physiology of the high-pressure neurological syndrome--compression rate effects. ( 110755 )
1979
29
High pressure neurological syndrome: antagonistic effects of helium pressure and inhalation anesthetics on the dopamine-sensitive cyclic AMP response. ( 231338 )
1979
30
Stages in development of high-pressure neurological syndrome in the mouse. ( 457554 )
1979
31
Rate factors in development of the high-pressure neurological syndrome. ( 804465 )
1975
32
Intra- and interspecies variability of vertebrate high-pressure neurological syndrome. ( 4215787 )
1974
33
N2, H2, and N2O antagonism of high pressure neurological syndrome in mice. ( 4469182 )
1974
34
Inert gas narcosis, the high pressure neurological syndrome, and the critical volume hypothesis. ( 4843793 )
1974

Variations for High Pressure Neurological Syndrome

Expression for High Pressure Neurological Syndrome

Search GEO for disease gene expression data for High Pressure Neurological Syndrome.

Pathways for High Pressure Neurological Syndrome

Pathways related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 CACNA1B CACNA1C GRIN1 GRIN2A
2
Show member pathways
12.63 CACNA1B CACNA1C GRIN1 GRIN2A
3
Show member pathways
12.56 CACNA1B GABRR3 GRIN1 GRIN2A
4
Show member pathways
12.22 CACNA1B CACNA1C GABRR3
5 11.94 CACNA1C GRIN1 GRIN2A
6 11.81 CACNA1B CACNA1C GRIN1 GRIN2A
7
Show member pathways
11.76 CACNA1C GRIN1 GRIN2A
8
Show member pathways
11.7 CACNA1B CACNA1C
9 11.66 CACNA1B CACNA1C
10
Show member pathways
11.65 GRIN1 GRIN2A
11
Show member pathways
11.57 CACNA1B CACNA1C
12
Show member pathways
11.54 CACNA1B CACNA1C GRIN1 GRIN2A
13
Show member pathways
11.53 GRIN1 GRIN2A
14
Show member pathways
11.5 CACNA1C GRIN1 GRIN2A
15 11.44 GRIN1 GRIN2A
16 11.32 CACNA1B CACNA1C
17 11.23 CACNA1B CACNA1C
18 10.97 GRIN1 GRIN2A
19 10.86 CACNA1B CACNA1C
20 10.8 GRIN1 GRIN2A
21 10.53 CACNA1B GABRR3 GRIN1 GRIN2A
22 10.4 CACNA1B CACNA1C

GO Terms for High Pressure Neurological Syndrome

Cellular components related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.81 CACNA1C GABRR3 GRIN1 GRIN2A
2 dendrite GO:0030425 9.67 CACNA1B CACNA1C GRIN1
3 neuron projection GO:0043005 9.65 GABRR3 GRIN1 GRIN2A
4 cell junction GO:0030054 9.62 CACNA1C GABRR3 GRIN1 GRIN2A
5 postsynaptic density GO:0014069 9.61 CACNA1C GRIN1 GRIN2A
6 integral component of postsynaptic density membrane GO:0099061 9.46 GRIN1 GRIN2A
7 synapse GO:0045202 9.46 CACNA1C GABRR3 GRIN1 GRIN2A
8 voltage-gated calcium channel complex GO:0005891 9.4 CACNA1B CACNA1C
9 synaptic membrane GO:0097060 9.37 GRIN1 GRIN2A
10 postsynaptic density membrane GO:0098839 9.26 GRIN1 GRIN2A
11 NMDA selective glutamate receptor complex GO:0017146 8.96 GRIN1 GRIN2A
12 postsynaptic membrane GO:0045211 8.92 CACNA1C GABRR3 GRIN1 GRIN2A

Biological processes related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.69 CACNA1B GABRR3 GRIN2A
2 response to ethanol GO:0045471 9.61 GRIN1 GRIN2A
3 calcium-mediated signaling GO:0019722 9.61 GRIN1 GRIN2A
4 calcium ion transmembrane transport GO:0070588 9.61 CACNA1B CACNA1C GRIN2A
5 memory GO:0007613 9.6 GRIN1 GRIN2A
6 excitatory postsynaptic potential GO:0060079 9.59 GRIN1 GRIN2A
7 learning GO:0007612 9.58 GRIN1 GRIN2A
8 learning or memory GO:0007611 9.58 GRIN1 GRIN2A
9 regulation of membrane potential GO:0042391 9.58 GABRR3 GRIN1 GRIN2A
10 sensory perception of pain GO:0019233 9.57 GRIN1 GRIN2A
11 regulation of synaptic plasticity GO:0048167 9.56 GRIN1 GRIN2A
12 visual learning GO:0008542 9.55 GRIN1 GRIN2A
13 response to amphetamine GO:0001975 9.54 GRIN1 GRIN2A
14 cellular response to amyloid-beta GO:1904646 9.52 GRIN1 GRIN2A
15 calcium ion import GO:0070509 9.49 CACNA1B CACNA1C
16 ionotropic glutamate receptor signaling pathway GO:0035235 9.48 GRIN1 GRIN2A
17 startle response GO:0001964 9.46 GRIN1 GRIN2A
18 ion transmembrane transport GO:0034220 9.46 CACNA1C GABRR3 GRIN1 GRIN2A
19 excitatory chemical synaptic transmission GO:0098976 9.37 GRIN1 GRIN2A
20 ion transport GO:0006811 9.35 CACNA1B CACNA1C GABRR3 GRIN1 GRIN2A
21 calcium ion transmembrane import into cytosol GO:0097553 9.32 GRIN1 GRIN2A
22 protein localization to postsynaptic membrane GO:1903539 9.26 GRIN1 GRIN2A
23 calcium ion transport GO:0006816 8.92 CACNA1B CACNA1C GRIN1 GRIN2A

Molecular functions related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated calcium channel activity GO:0005245 9.43 CACNA1B CACNA1C
2 cation channel activity GO:0005261 9.4 GRIN1 GRIN2A
3 ionotropic glutamate receptor activity GO:0004970 9.37 GRIN1 GRIN2A
4 high voltage-gated calcium channel activity GO:0008331 9.32 CACNA1B CACNA1C
5 NMDA glutamate receptor activity GO:0004972 9.26 GRIN1 GRIN2A
6 calcium channel activity GO:0005262 9.26 CACNA1B CACNA1C GRIN1 GRIN2A
7 glutamate-gated calcium ion channel activity GO:0022849 9.16 GRIN1 GRIN2A
8 ion channel activity GO:0005216 9.02 CACNA1B CACNA1C GABRR3 GRIN1 GRIN2A

Sources for High Pressure Neurological Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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