MCID: HGH001
MIFTS: 28

High Pressure Neurological Syndrome

Categories: Neuronal diseases

Aliases & Classifications for High Pressure Neurological Syndrome

MalaCards integrated aliases for High Pressure Neurological Syndrome:

Name: High Pressure Neurological Syndrome 12 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3230
MeSH 44 D006610
UMLS 70 C0019537

Summaries for High Pressure Neurological Syndrome

MalaCards based summary : High Pressure Neurological Syndrome is related to tremor and myoclonus, and has symptoms including hyperexplexia An important gene associated with High Pressure Neurological Syndrome is GRIN1 (Glutamate Ionotropic Receptor NMDA Type Subunit 1), and among its related pathways/superpathways are Developmental Biology and Pathways of neurodegeneration - multiple diseases. Affiliated tissues include globus pallidus and temporal lobe.

Related Diseases for High Pressure Neurological Syndrome

Graphical network of the top 20 diseases related to High Pressure Neurological Syndrome:



Diseases related to High Pressure Neurological Syndrome

Symptoms & Phenotypes for High Pressure Neurological Syndrome

UMLS symptoms related to High Pressure Neurological Syndrome:


hyperexplexia

Drugs & Therapeutics for High Pressure Neurological Syndrome

Search Clinical Trials , NIH Clinical Center for High Pressure Neurological Syndrome

Cochrane evidence based reviews: high pressure neurological syndrome

Genetic Tests for High Pressure Neurological Syndrome

Anatomical Context for High Pressure Neurological Syndrome

MalaCards organs/tissues related to High Pressure Neurological Syndrome:

40
Globus Pallidus, Temporal Lobe

Publications for High Pressure Neurological Syndrome

Articles related to High Pressure Neurological Syndrome:

(show top 50) (show all 101)
# Title Authors PMID Year
1
The Mechanism of NMDA Receptor Hyperexcitation in High Pressure Helium and Hyperbaric Oxygen. 61
32982789 2020
2
The effect of high pressure on the NMDA receptor: molecular dynamics simulations. 61
31346207 2019
3
Systematic review on the effects of medication under hyperbaric conditions: consequences for the diver. 61
31177519 2019
4
High Pressure Stress Response: Involvement of NMDA Receptor Subtypes and Molecular Markers. 61
31611813 2019
5
Evaluation of Divers' Neuropsychometric Effectiveness and High-Pressure Neurological Syndrome via Computerized Test Battery Package and Questionnaires in Operational Setting. 61
31787904 2019
6
Marine Mammals' NMDA Receptor Structure: Possible Adaptation to High Pressure Environment. 61
30524300 2018
7
Selective pressure modulation of synaptic voltage-dependent calcium channels-involvement in HPNS mechanism. 61
27273194 2016
8
Theoretical considerations on the ultimate depth that could be reached by saturation human divers. 61
27867478 2016
9
The Enigma of the Dichotomic Pressure Response of GluN1-4a/b Splice Variants of NMDA Receptor: Experimental and Statistical Analyses. 61
27375428 2016
10
High Pressure and [Ca 2+ ] Produce an Inverse Modulation of Synaptic Input Strength and Network Excitability in the Rat Dentate Gyrus. 61
27729848 2016
11
The N-methyl-D-aspartate receptor's neglected subunit - GluN1 matters under normal and hyperbaric conditions. 61
26202884 2015
12
Acute combined pressure and temperature exposures on a shallow-water crustacean: novel insights into the stress response and high pressure neurological syndrome. 61
25433335 2015
13
Neurological complications of underwater diving. 61
25666773 2015
14
Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure-a suggested HPNS partial mechanism. 61
24904281 2014
15
Extremely deep recreational dives: the risk for carbon dioxide (CO(2)) retention and high pressure neurological syndrome (HPNS). 61
22669812 2012
16
Pressure-selective modulation of NMDA receptor subtypes may reflect 3D structural differences. 61
22973194 2012
17
Hyperbaric pressure effects on voltage-dependent Ca+2 channels: relevance to HPNS. 61
20929182 2010
18
The efficacy of physiological and pharmacological N-methyl-D-aspartate receptor block is greatly reduced under hyperbaric conditions. 61
20457226 2010
19
Enduring medial perforant path short-term synaptic depression at high pressure. 61
21048901 2010
20
Differential modulation of cerebellar climbing fiber and parallel fiber synaptic responses at high pressure. 61
19057002 2009
21
Differential effect of high pressure on NMDA receptor currents in Xenopus laevis oocytes. 61
22692751 2008
22
[High pressure neurological syndrome]. 61
18008270 2007
23
High pressure modulation of NMDA receptor dependent excitability. 61
17439491 2007
24
Modulation of isolated N-methyl-d-aspartate receptor response under hyperbaric conditions. 61
17229094 2006
25
CNS manifestations of HPNS: revisited. 61
16869534 2006
26
Enhanced excitability compensates for high-pressure-induced depression of cortical inputs to the hippocampus. 61
15254072 2004
27
Early and late morphological effects of experimental HPNS--animal model of psychosis? 61
11370733 2001
28
High pressure enhanced NMDA activity in the striatum and the globus pallidus: relationships with myoclonia and locomotor and motor activity in rat. 61
10661496 2000
29
Crucial role of the 5-HT2C receptor, but not of the 5-HT2A receptor, in the down regulation of stimulated dopamine release produced by pressure exposure in freely moving rats. 61
9689464 1998
30
Modulation by GABA transmission in the substantia nigra compacta and reticulata of locomotor activity in rats exposed to high pressure. 61
9631426 1998
31
Early morphological findings in experimental high pressure neurological syndrome. 61
9495642 1997
32
Pressure induces striatal serotonin and dopamine increases: a simultaneous analysis in free-moving microdialysed rats. 61
9464657 1997
33
Effects of high helium pressure on intracellular and field potential responses in the CA1 region of the in vitro rat hippocampus. 61
8996806 1996
34
Contribution of central 5-HT2 receptors in the occurrence of locomotor activity and myoclonia in freely moving rats exposed to high pressure. 61
8981448 1996
35
Evidence for inert gas narcosis mechanisms in the occurrence of psychotic-like episodes at pressure environment. 61
8747169 1995
36
Effects of compression rate on rats carotid blood flow. 61
9338091 1995
37
Evidence for inert gas narcosis mechanisms in the occurrence of psychotic-like episodes at pressure environment. 61
7605930 1995
38
Effect of nitrogen narcosis on extracellular levels of dopamine and its metabolites in the rat striatum, using intracerebral microdialysis. 61
7895072 1994
39
High-pressure neurological syndrome (HPNS). 61
7941956 1994
40
Protection from high pressure induced hyperexcitability by the AMPA/kainate receptor antagonists GYKI 52466 and LY 293558. 61
7936094 1994
41
Lack of effect of lamotrigine against HPNS in rodent and primate models. 61
7913227 1994
42
Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome. 61
7912632 1994
43
Effects of elevated pressures of inert gases on cytosolic free Ca2+ of cultured human neuroblastoma cells stimulated with carbachol: relevance to high pressure neurological syndrome. 61
8149411 1994
44
Relationship between emotional status and spontaneous behavior in rats exposed to high pressure. 61
8248365 1993
45
The orally active NMDA receptor antagonist CGP 39551 ameliorates the high pressure neurological syndrome in Papio anubis. 61
7902190 1993
46
Behavior genetic analyses of drug withdrawal. 61
7748342 1993
47
Effects of high pressure on striatal dopamine release in freely moving rats: a microdialysis study. 61
1491792 1992
48
Pressure reversed extracellular striatal dopamine decrease produced by D1 receptor agonist SKF 38393, and D2 receptor agonist LY 171555, but failed to change the effect of the activation of both D1 and D2 receptors. 61
1359460 1992
49
A hypothesis regarding possible interactions between the pressure-induced disorders in dopaminergic and amino-acidergic transmission. 61
1336154 1992
50
Interactions of the beta carboline abecarnil with the high pressure neurological syndrome in a primate model. 61
1365651 1992

Variations for High Pressure Neurological Syndrome

Expression for High Pressure Neurological Syndrome

Search GEO for disease gene expression data for High Pressure Neurological Syndrome.

Pathways for High Pressure Neurological Syndrome

Pathways related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 GRIN2D GRIN2A GRIN1 CACNA1C
2
Show member pathways
13.09 GRIN2D GRIN2A GRIN1 CACNA1C
3
Show member pathways
13.01 GRIN2D GRIN2A GRIN1 GBP4
4
Show member pathways
13.01 HTR2C GRIN2D GRIN2A GRIN1 CACNA1C
5
Show member pathways
12.8 GRIN2D GRIN2A GRIN1 CACNA1C
6
Show member pathways
12.74 GRIN2D GRIN2A GRIN1 CACNA1C
7
Show member pathways
12.64 GRIN2D GRIN2A GRIN1
8
Show member pathways
12.56 GRIN2D GRIN2A GRIN1 CACNA1C
9
Show member pathways
12.36 GRIN2D GRIN2A GRIN1
10 12.14 GRIN2D GRIN2A GRIN1 CACNA1C
11 12.07 GRIN2D GRIN2A GRIN1 CACNA1C
12
Show member pathways
12 GRIN2D GRIN2A GRIN1
13 11.89 GRIN2D GRIN2A GRIN1
14
Show member pathways
11.84 GRIN2D GRIN2A GRIN1
15 11.8 GRIN2D GRIN2A GRIN1 CACNA1C
16 11.68 HTR2C CACNA1C
17
Show member pathways
11.65 GRIN2D GRIN2A GRIN1
18 11.54 GRIN2D GRIN2A GRIN1
19
Show member pathways
11.53 GRIN2D GRIN2A GRIN1 CACNA1C
20 11.4 HTR2C GRIN2D GRIN2A GRIN1 CACNA1C
21
Show member pathways
11.29 GRIN2D GRIN2A GRIN1 CACNA1C
22 11.23 GRIN2D GRIN2A GRIN1
23 11.04 GRIN2D GRIN2A GRIN1
24 10.94 GRIN2D GRIN2A GRIN1
25 10.76 GRIN2D GRIN2A GRIN1

GO Terms for High Pressure Neurological Syndrome

Cellular components related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.93 HTR2C GRIN2D GRIN2A GRIN1 GBP4 CACNA1C
2 integral component of plasma membrane GO:0005887 9.72 HTR2C GRIN2D GRIN2A GRIN1 CACNA1C
3 cell junction GO:0030054 9.67 GRIN2D GRIN2A GRIN1 CACNA1C
4 dendrite GO:0030425 9.65 HTR2C GRIN1 CACNA1C
5 synapse GO:0045202 9.65 HTR2C GRIN2D GRIN2A GRIN1 CACNA1C
6 postsynaptic density GO:0014069 9.58 GRIN2A GRIN1 CACNA1C
7 synaptic membrane GO:0097060 9.43 GRIN2A GRIN1
8 postsynaptic density membrane GO:0098839 9.33 GRIN2D GRIN2A CACNA1C
9 postsynaptic membrane GO:0045211 9.26 GRIN2D GRIN2A GRIN1 CACNA1C
10 NMDA selective glutamate receptor complex GO:0017146 8.8 GRIN2D GRIN2A GRIN1

Biological processes related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.73 GRIN2D GRIN2A GRIN1 CACNA1C
2 brain development GO:0007420 9.67 GRIN2D GRIN2A GRIN1
3 chemical synaptic transmission GO:0007268 9.63 HTR2C GRIN2A GRIN1
4 response to ethanol GO:0045471 9.56 GRIN2A GRIN1
5 regulation of membrane potential GO:0042391 9.55 GRIN2A GRIN1
6 cellular response to amyloid-beta GO:1904646 9.54 GRIN2A GRIN1
7 calcium-mediated signaling GO:0019722 9.54 GRIN2D GRIN2A GRIN1
8 long-term synaptic potentiation GO:0060291 9.52 GRIN2D GRIN2A
9 visual learning GO:0008542 9.51 GRIN2A GRIN1
10 excitatory postsynaptic potential GO:0060079 9.5 GRIN2D GRIN2A GRIN1
11 regulation of NMDA receptor activity GO:2000310 9.48 GRIN2A GRIN1
12 regulation of synaptic plasticity GO:0048167 9.43 GRIN2D GRIN2A GRIN1
13 startle response GO:0001964 9.4 GRIN2D GRIN2A
14 ionotropic glutamate receptor signaling pathway GO:0035235 9.33 GRIN2D GRIN2A GRIN1
15 excitatory chemical synaptic transmission GO:0098976 9.13 GRIN2D GRIN2A GRIN1
16 calcium ion transmembrane import into cytosol GO:0097553 8.8 GRIN2D GRIN2A GRIN1

Molecular functions related to High Pressure Neurological Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.58 GRIN2D GRIN2A GRIN1
2 ion channel activity GO:0005216 9.56 GRIN2D GRIN2A GRIN1 CACNA1C
3 calcium channel activity GO:0005262 9.54 GRIN2A GRIN1 CACNA1C
4 ligand-gated ion channel activity GO:0015276 9.5 GRIN2D GRIN2A GRIN1
5 amyloid-beta binding GO:0001540 9.43 GRIN2A GRIN1
6 ionotropic glutamate receptor activity GO:0004970 9.33 GRIN2D GRIN2A GRIN1
7 NMDA glutamate receptor activity GO:0004972 9.13 GRIN2D GRIN2A GRIN1
8 glutamate-gated calcium ion channel activity GO:0022849 8.8 GRIN2D GRIN2A GRIN1

Sources for High Pressure Neurological Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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