MCID: HLR002
MIFTS: 27

Hilar Lung Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Hilar Lung Carcinoma

MalaCards integrated aliases for Hilar Lung Carcinoma:

Name: Hilar Lung Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:8207
NCIt 49 C7454
UMLS 71 C1334445

Summaries for Hilar Lung Carcinoma

MalaCards based summary : Hilar Lung Carcinoma is related to hemorrhagic fever-renal syndrome and c1q nephropathy. An important gene associated with Hilar Lung Carcinoma is CD79A (CD79a Molecule), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Primary immunodeficiency. Affiliated tissues include lung.

Related Diseases for Hilar Lung Carcinoma

Diseases related to Hilar Lung Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever-renal syndrome 10.0 CD79A CD40LG
2 c1q nephropathy 10.0 CD79A CD40LG
3 immunoglobulin g deficiency 10.0 CD79A CD40LG
4 cryofibrinogenemia 10.0 CD79A CD40LG
5 monoclonal paraproteinemia 10.0 CD79A CD40LG
6 ocular toxoplasmosis 10.0 CD79A CD40LG
7 toxoplasmosis 10.0 CD79A CD40LG
8 cerebral lymphoma 10.0 CD79A CD40LG
9 selective igg deficiency disease 10.0 CD79A CD40LG
10 alpha chain disease 10.0 CD79A CD40LG
11 congenital syphilis 10.0 CD79A CD40LG
12 syphilis 10.0 CD79A CD40LG
13 anisakiasis 10.0 CD79A CD40LG
14 secondary syphilis 10.0 CD79A CD40LG
15 heavy chain disease 10.0 CD79A CD40LG
16 immunoglobulin a deficiency 1 10.0 CD79A CD40LG
17 pustulosis palmaris et plantaris 10.0 CD79A CD40LG
18 parotitis 10.0 CD79A CD40LG
19 calciphylaxis 10.0 CD79A CD40LG
20 pleural empyema 10.0 CD79A CD40LG
21 sporotrichosis 10.0 CD79A CD40LG
22 dysgammaglobulinemia 10.0 CD79A CD40LG
23 waldenstroem's macroglobulinemia 10.0 CD79A CD40LG
24 acute poststreptococcal glomerulonephritis 10.0 CD79A CD40LG
25 glomerulonephritis 10.0 CD79A CD40LG
26 congenital toxoplasmosis 9.9 CD79A CD40LG
27 persistent generalized lymphadenopathy 9.9 CD79A CD40LG
28 giardiasis 9.9 CD79A CD40LG
29 henoch-schoenlein purpura 9.9 CD79A CD40LG
30 purpura 9.9 CD79A CD40LG
31 hypersensitivity reaction type iii disease 9.9 CD79A CD40LG
32 amebiasis 9.9 CD79A CD40LG
33 mesangial proliferative glomerulonephritis 9.9 CD79A CD40LG
34 cryptosporidiosis 9.9 CD79A CD40LG
35 immunoglobulin alpha deficiency 9.9 CD79A CD40LG
36 bacteriuria 9.9 CD79A CD40LG
37 protein-losing enteropathy 9.9 CD79A CD40LG
38 lipoid nephrosis 9.9 CD79A CD40LG
39 immunodeficiency with hyper-igm, type 1 9.9 CD79A CD40LG
40 guillain-barre syndrome 9.9 CD79A CD40LG
41 dermatitis herpetiformis 9.9 CD79A CD40LG
42 iga glomerulonephritis 9.9 CD79A CD40LG
43 cryoglobulinemia 9.9 CD79A CD40LG
44 meningoencephalitis 9.9 CD79A CD40LG
45 agammaglobulinemia, x-linked 9.9 CD79A CD40LG
46 agammaglobulinemia 9.9 CD79A CD40LG
47 chlamydia 9.9 CD79A CD40LG
48 retroperitoneal lymphoma 9.8 MME CD40LG
49 antiphospholipid syndrome 9.8 CD79A CD40LG
50 endocrine exophthalmos 9.8 MME CD40LG

Graphical network of the top 20 diseases related to Hilar Lung Carcinoma:



Diseases related to Hilar Lung Carcinoma

Symptoms & Phenotypes for Hilar Lung Carcinoma

Drugs & Therapeutics for Hilar Lung Carcinoma

Search Clinical Trials , NIH Clinical Center for Hilar Lung Carcinoma

Genetic Tests for Hilar Lung Carcinoma

Anatomical Context for Hilar Lung Carcinoma

MalaCards organs/tissues related to Hilar Lung Carcinoma:

40
Lung

Publications for Hilar Lung Carcinoma

Articles related to Hilar Lung Carcinoma:

# Title Authors PMID Year
1
[Successful lingular segmentectomy using bronchoplasty in a patient with early hilar second primary lung carcinoma]. 61
11995316 2002
2
Endoscopic evaluation of centrally located early squamous cell carcinoma of the lung. 61
11267959 2001
3
Surgical management of early stage central (hilar) and peripheral nonsmall cell lung carcinoma. 61
11147622 2000

Variations for Hilar Lung Carcinoma

Cosmic variations for Hilar Lung Carcinoma:

9 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
2 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
3 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 6
4 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
5 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 6
6 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
7 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
8 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 6
9 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 6
10 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
11 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
12 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 6
13 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 6
14 COSM127070824 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 6
15 COSM127059821 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 6
16 COSM85195038 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 6
17 COSM130300868 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 6
18 COSM131090496 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 6
19 COSM131094722 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 6
20 COSM131094002 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 6
21 COSM87049256 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 6
22 COSM85721789 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 6
23 COSM90140992 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 6
24 COSM90145840 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 6
25 COSM87090089 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 6
26 COSM87898991 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 6
27 COSM87901497 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 6
28 COSM87935416 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 6
29 COSM87904420 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 6
30 COSM87898444 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 6
31 COSM87906107 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 6
32 COSM87909792 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 6
33 COSM87940740 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 6
34 COSM87899785 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 6
35 COSM87902162 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 6
36 COSM87915599 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 6
37 COSM87897914 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 6
38 COSM87899377 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 6
39 COSM87900565 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 6
40 COSM87918616 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 6
41 COSM87897711 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 6
42 COSM87900157 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 6
43 COSM87942817 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 6
44 COSM87903076 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 6
45 COSM87898836 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 6
46 COSM87898881 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 6
47 COSM150205149 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 6
48 COSM85378871 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 6
49 COSM90180942 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 6
50 COSM90180404 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 6

Expression for Hilar Lung Carcinoma

Search GEO for disease gene expression data for Hilar Lung Carcinoma.

Pathways for Hilar Lung Carcinoma

Pathways related to Hilar Lung Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 MME CD79A
2 10.54 CD79A CD40LG
3 10.13 MME CD40LG

GO Terms for Hilar Lung Carcinoma

Cellular components related to Hilar Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.62 MME CD79A

Biological processes related to Hilar Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD79A CD40LG
2 B cell proliferation GO:0042100 8.62 CD79A CD40LG

Sources for Hilar Lung Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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