Hilar Lung Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hilar Lung Neoplasm

MalaCards integrated aliases for Hilar Lung Neoplasm:

Name: Hilar Lung Neoplasm ¹¹ ¹⁴

Neoplasm of Hilus of Lung ¹¹ ⁷¹

Lung Hilum Carcinoma ⁷¹

Lung Hilum Tumor ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5767

NCIt ⁴⁹ C5671

SNOMED-CT ⁶⁸ 126707007

UMLS ⁷¹ C1290358 C1334445

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Summaries for Hilar Lung Neoplasm

MalaCards based summary: Hilar Lung Neoplasm, also known as neoplasm of hilus of lung, is related to lung hilum cancer and oral tuberculosis. An important gene associated with Hilar Lung Neoplasm is CD8A (CD8a Molecule), and among its related pathways/superpathways are CD28 co-stimulation and T-cell activation SARS-CoV-2. Affiliated tissues include lung.

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Related Diseases for Hilar Lung Neoplasm

Diseases related to Hilar Lung Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 348)

#	Related Disease	Score	Top Affiliating Genes
1	lung hilum cancer	11.4
2	oral tuberculosis	10.0	CD8A CD4
3	early yaws	10.0	CD8A CD4
4	ventilation pneumonitis	10.0	CD8A CD4
5	diffuse infiltrative lymphocytosis syndrome	9.9	CD8A CD4
6	wissler-fanconi syndrome	9.9	CD8A CD4
7	autoimmune lymphoproliferative syndrome	9.9	CD8A CD4
8	autoimmune lymphoproliferative syndrome, type iia	9.9	CD8A CD4
9	encephalitozoonosis	9.9	CD8A CD4
10	type 1 diabetes mellitus 23	9.9	CD8A CD4
11	cork-handlers' disease	9.9	CD8A CD4
12	follicular mucinosis	9.9	CD8A CD4
13	suppurative lymphadenitis	9.9	CD8A CD4
14	bird fancier's lung	9.9	CD8A CD4
15	parapsoriasis	9.9	CD8A CD4
16	primary syphilis	9.9	CD8A CD4
17	syphilis	9.9	CD8A CD4
18	granulomatous angiitis	9.9	CD8A CD4
19	primary cutaneous gamma-delta t-cell lymphoma	9.9	CD8A CD4
20	gastroduodenitis	9.9	CD8A CD4
21	duodenitis	9.9	CD8A CD4
22	thymic dysplasia	9.9	CD8A CD4
23	splenic abscess	9.9	CD8A CD4
24	mooren's ulcer	9.9	CD8A CD4
25	herpes simplex virus keratitis	9.9	CD8A CD4
26	granulomatous dermatitis	9.9	CD8A CD4
27	acute retinal necrosis syndrome	9.9	CD8A CD4
28	granulomatous hepatitis	9.9	CD8A CD4
29	norwegian scabies	9.9	CD8A CD4
30	scabies	9.9	CD8A CD4
31	orbital cellulitis	9.9	CD8A CD4
32	cellulitis	9.9	CD8A CD4
33	acute orbital inflammation	9.9	CD8A CD4
34	viral exanthem	9.9	CD8A CD4
35	exanthem	9.9	CD8A CD4
36	tertiary syphilis	9.9	CD8A CD4
37	spongiotic dermatitis	9.9	CD8A CD4
38	cerebritis	9.9	CD8A CD4
39	skin sarcoidosis	9.9	CD8A CD4
40	metal allergy	9.9	CD8A CD4
41	autoimmune peripheral neuropathy	9.9	CD8A CD4
42	secondary syphilis	9.9	CD8A CD4
43	gastrointestinal tuberculosis	9.9	CD8A CD4
44	glanders	9.9	CD8A CD4
45	adenoid hypertrophy	9.9	CD8A CD4
46	abdominal tuberculosis	9.9	CD8A CD4
47	retinitis pigmentosa 46	9.9	CD8A CD4
48	ulcerative stomatitis	9.9	CD8A CD4
49	tracheitis	9.9	CD8A CD4
50	microsporidiosis	9.9	CD8A CD4

Graphical network of the top 20 diseases related to Hilar Lung Neoplasm:

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Symptoms & Phenotypes for Hilar Lung Neoplasm

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Drugs & Therapeutics for Hilar Lung Neoplasm

Search Clinical Trials, NIH Clinical Center for Hilar Lung Neoplasm

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Genetic Tests for Hilar Lung Neoplasm

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Anatomical Context for Hilar Lung Neoplasm

Organs/tissues related to Hilar Lung Neoplasm:

MalaCards : Lung

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Publications for Hilar Lung Neoplasm

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Genes for Hilar Lung Neoplasm

Genes related to Hilar Lung Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CD8A	CD8a Molecule	Protein Coding	3.06	DISEASES inferred ¹⁴
2	CD4	CD4 Molecule	Protein Coding	2.95	DISEASES inferred ¹⁴

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Variations for Hilar Lung Neoplasm

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Expression for Hilar Lung Neoplasm

Search GEO for disease gene expression data for Hilar Lung Neoplasm.

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Pathways for Hilar Lung Neoplasm

Pathways related to Hilar Lung Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ CTLA4 Signaling ⁶⁴ VEGFR2 mediated vascular permeability ⁶⁶	11.78	CD8A CD4
2	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.55	CD8A CD4
3	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.39	CD8A CD4
4	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.3	CD8A CD4
5	Innate Lymphoid Cells Differentiation ⁶⁵	11.06	CD8A CD4
6	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	10.84	CD8A CD4
7	Dendritic Cells Developmental Lineage Pathway ⁶⁵	10.49	CD8A CD4

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GO Terms for Hilar Lung Neoplasm

Cellular components related to Hilar Lung Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	T cell receptor complex	GO:0042101	8.92	CD8A CD4

Biological processes related to Hilar Lung Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.26	CD8A CD4
2	T cell activation	GO:0042110	8.92	CD8A CD4

Molecular functions related to Hilar Lung Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:0015026	8.92	CD8A CD4

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Sources for Hilar Lung Neoplasm

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: HLR001 MIFTS: 20	Hilar Lung Neoplasm Categories: Cancer diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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