MCID: HST008
MIFTS: 29

Histiocytic and Dendritic Cell Cancer

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Histiocytic and Dendritic Cell Cancer

MalaCards integrated aliases for Histiocytic and Dendritic Cell Cancer:

Name: Histiocytic and Dendritic Cell Cancer 12 15
Histiocytic and Dendritic Cell 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5621
NCIt 50 C9294
UMLS 73 C1334030

Summaries for Histiocytic and Dendritic Cell Cancer

Disease Ontology : 12 A sarcoma and hematologic cancer that derives from follicular lymphoma.

MalaCards based summary : Histiocytic and Dendritic Cell Cancer, also known as histiocytic and dendritic cell, is related to langerhans cell sarcoma and follicular dendritic cell sarcoma. An important gene associated with Histiocytic and Dendritic Cell Cancer is CR2 (Complement C3d Receptor 2), and among its related pathways/superpathways are Innate Immune System and Immune response Fc epsilon RI pathway. Affiliated tissues include t cells, liver and spleen, and related phenotypes are hematopoietic system and immune system

Related Diseases for Histiocytic and Dendritic Cell Cancer

Diseases related to Histiocytic and Dendritic Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 langerhans cell sarcoma 31.9 CD163 CD207 CR1 CR2
2 follicular dendritic cell sarcoma 31.6 CLU CR1 CR2 DSP
3 interdigitating dendritic cell sarcoma 31.6 CD163 CR1 CR2 POLQ PTPRC
4 histiocytic sarcoma 29.9 CD163 CR1 CR2
5 parapharyngeal meningioma 10.2 CR1 CR2
6 t-cell/histiocyte rich large b cell lymphoma 10.2 CR1 CR2
7 liver inflammatory pseudotumor 10.2 CR2 PTPRC
8 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 CR2 PTPRC
9 lateral medullary syndrome 10.2 CR1 CR2
10 ovarian lymphoma 10.2 CR2 PTPRC
11 spleen cancer 10.2 CD163 CR2
12 cavernous sinus meningioma 10.2 CD163 CD207
13 castleman disease 10.1 CR1 CR2
14 rosai-dorfman disease 10.1 CD163 CR2
15 lobomycosis 10.1 CR2 LYZ
16 photokeratitis 10.1 CD163 PTPRC
17 malignant giant cell tumor of soft parts 10.1 LYZ PTPRC
18 central nervous system tuberculosis 10.1 CD163 CD207
19 central nervous system sarcoma 10.1 CD163 LYZ
20 adult xanthogranuloma 10.1 CD163 LYZ
21 trigeminal nerve neoplasm 10.1 LYZ PTPRC
22 neurilemmoma of the fifth cranial nerve 10.1 LYZ PTPRC
23 dermis tumor 10.1 CD163 LYZ
24 reticulum cell sarcoma 10.1 CR1 CR2 PTPRC
25 lymphatic system cancer 10.1 LYZ PTPRC
26 reticulosarcoma 10.0 CLU PTPRC
27 langerhans cell histiocytosis 10.0 CD163 CD207
28 malignant fibroxanthoma 10.0 LYZ PTPRC
29 retinal hemangioblastoma 10.0 CLU LYZ
30 histiocytosis 10.0 CD163 CD207 PTPRC
31 lymphatic system disease 10.0 CD207 LYZ
32 leukocyte disease 10.0 CR2 PTPRC
33 histiocytoma 10.0 CD163 PTPRC
34 erysipeloid 10.0 LYZ PPP3CA
35 non-langerhans-cell histiocytosis 10.0 CD163 CD207 LYZ
36 inflammatory myofibroblastic tumor 9.9 CR1 CR2
37 dendritic cell tumor 9.9 CD207 CR1 CR2 PTPRC
38 sarcoma 9.9
39 lymphangiosarcoma 9.9 DSP LYZ
40 reticulohistiocytic granuloma 9.8 CD163 CD207 LYZ PTPRC

Graphical network of the top 20 diseases related to Histiocytic and Dendritic Cell Cancer:



Diseases related to Histiocytic and Dendritic Cell Cancer

Symptoms & Phenotypes for Histiocytic and Dendritic Cell Cancer

MGI Mouse Phenotypes related to Histiocytic and Dendritic Cell Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CD163 CD207 CR2 LYZ POLQ PPP3CA
2 immune system MP:0005387 9.56 CD163 CD207 CLU CR2 LYZ POLQ
3 renal/urinary system MP:0005367 9.02 CLU CR2 LYZ PPP3CA PTPRC

Drugs & Therapeutics for Histiocytic and Dendritic Cell Cancer

Search Clinical Trials , NIH Clinical Center for Histiocytic and Dendritic Cell Cancer

Genetic Tests for Histiocytic and Dendritic Cell Cancer

Anatomical Context for Histiocytic and Dendritic Cell Cancer

MalaCards organs/tissues related to Histiocytic and Dendritic Cell Cancer:

41
T Cells, Liver, Spleen, B Cells

Publications for Histiocytic and Dendritic Cell Cancer

Articles related to Histiocytic and Dendritic Cell Cancer:

# Title Authors Year
1
Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders. ( 26752545 )
2016
2
Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms. ( 24720374 )
2014
3
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. ( 20656318 )
2010

Variations for Histiocytic and Dendritic Cell Cancer

Expression for Histiocytic and Dendritic Cell Cancer

Search GEO for disease gene expression data for Histiocytic and Dendritic Cell Cancer.

Pathways for Histiocytic and Dendritic Cell Cancer

GO Terms for Histiocytic and Dendritic Cell Cancer

Cellular components related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 9.26 CLU PTPRC
2 ficolin-1-rich granule membrane GO:0101003 9.16 CR1 DSP
3 extracellular exosome GO:0070062 9.1 CLU CR1 CR2 DSP LYZ PTPRC
4 cytoplasmic side of plasma membrane GO:0009898 8.96 PPP3CA PTPRC

Biological processes related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.46 CR1 DSP LYZ PTPRC
2 antimicrobial humoral response GO:0019730 9.43 CLU LYZ
3 complement activation, classical pathway GO:0006958 9.43 CLU CR1 CR2
4 positive regulation of tumor necrosis factor production GO:0032760 9.4 CLU PTPRC
5 T cell activation GO:0042110 9.37 PPP3CA PTPRC
6 B cell proliferation GO:0042100 9.32 CR2 PTPRC
7 complement receptor mediated signaling pathway GO:0002430 8.96 CR1 CR2
8 regulation of complement activation GO:0030449 8.8 CLU CR1 CR2

Sources for Histiocytic and Dendritic Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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