MCID: HST008
MIFTS: 27

Histiocytic and Dendritic Cell Cancer

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Histiocytic and Dendritic Cell Cancer

MalaCards integrated aliases for Histiocytic and Dendritic Cell Cancer:

Name: Histiocytic and Dendritic Cell Cancer 12 15
Histiocytic and Dendritic Cell 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5621
NCIt 50 C9294
UMLS 73 C1334030

Summaries for Histiocytic and Dendritic Cell Cancer

Disease Ontology : 12 A sarcoma and hematologic cancer that derives from follicular lymphoma.

MalaCards based summary : Histiocytic and Dendritic Cell Cancer, also known as histiocytic and dendritic cell, is related to langerhans cell sarcoma and interdigitating dendritic cell sarcoma. An important gene associated with Histiocytic and Dendritic Cell Cancer is CR2 (Complement C3d Receptor 2), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and NF-kappaB Signaling. Affiliated tissues include t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Histiocytic and Dendritic Cell Cancer

Graphical network of the top 20 diseases related to Histiocytic and Dendritic Cell Cancer:



Diseases related to Histiocytic and Dendritic Cell Cancer

Symptoms & Phenotypes for Histiocytic and Dendritic Cell Cancer

GenomeRNAi Phenotypes related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.05 SPI1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.05 PTPRC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.05 SPI1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.05 PTPRC SPI1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.05 SPI1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.05 CD163
7 Increased shRNA abundance (Z-score > 2) GR00366-A-13 10.05 SPI1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.05 CD163
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.05 SPI1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.05 CD163 PTPRC SPI1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.05 SPI1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.05 CD163
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.05 PTPRC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.05 PTPRC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-41 10.05 PTPRC
16 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.05 SPI1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.05 PTPRC
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.05 CD163
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.05 CD163
20 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.05 CD163
21 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.05 CD163
22 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.05 CD163
23 Negative genetic interaction between MUS81-/- and MUS81+/+ GR00255-A-2 8.92 PPL PPP3CA PTPRC SPI1

MGI Mouse Phenotypes related to Histiocytic and Dendritic Cell Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD163 CD207 CR2 PPP3CA PTPRC SPI1
2 immune system MP:0005387 9.17 CD163 CD207 CLU CR2 PPP3CA PTPRC

Drugs & Therapeutics for Histiocytic and Dendritic Cell Cancer

Search Clinical Trials , NIH Clinical Center for Histiocytic and Dendritic Cell Cancer

Genetic Tests for Histiocytic and Dendritic Cell Cancer

Anatomical Context for Histiocytic and Dendritic Cell Cancer

MalaCards organs/tissues related to Histiocytic and Dendritic Cell Cancer:

41
T Cells

Publications for Histiocytic and Dendritic Cell Cancer

Articles related to Histiocytic and Dendritic Cell Cancer:

# Title Authors Year
1
Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders. ( 26752545 )
2016
2
Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms. ( 24720374 )
2014
3
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. ( 20656318 )
2010

Variations for Histiocytic and Dendritic Cell Cancer

Expression for Histiocytic and Dendritic Cell Cancer

Search GEO for disease gene expression data for Histiocytic and Dendritic Cell Cancer.

Pathways for Histiocytic and Dendritic Cell Cancer

GO Terms for Histiocytic and Dendritic Cell Cancer

Cellular components related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.5 CD163 CD207 CR1 CR2 PPL PPP3CA
2 membrane GO:0016020 9.28 CD163 CD207 CLU CR1 CR2 PPL

Biological processes related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement activation, classical pathway GO:0006958 9.33 CLU CR1 CR2
2 B cell proliferation GO:0042100 9.26 CR2 PTPRC
3 complement receptor mediated signaling pathway GO:0002430 8.96 CR1 CR2
4 regulation of complement activation GO:0030449 8.8 CLU CR1 CR2

Molecular functions related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 CR1 CR2

Sources for Histiocytic and Dendritic Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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