MCID: HST008
MIFTS: 30

Histiocytic and Dendritic Cell Cancer

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Histiocytic and Dendritic Cell Cancer

MalaCards integrated aliases for Histiocytic and Dendritic Cell Cancer:

Name: Histiocytic and Dendritic Cell Cancer 12 15
Histiocytic and Dendritic Cell 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5621
NCIt 50 C9294
UMLS 70 C1334030

Summaries for Histiocytic and Dendritic Cell Cancer

Disease Ontology : 12 A sarcoma and hematologic cancer that derives from follicular lymphoma.

MalaCards based summary : Histiocytic and Dendritic Cell Cancer, also known as histiocytic and dendritic cell, is related to interdigitating dendritic cell sarcoma and histiocytic sarcoma. An important gene associated with Histiocytic and Dendritic Cell Cancer is CR1 (Complement C3b/C4b Receptor 1 (Knops Blood Group)), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include myeloid, eye and lymph node.

Related Diseases for Histiocytic and Dendritic Cell Cancer

Diseases related to Histiocytic and Dendritic Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 interdigitating dendritic cell sarcoma 31.3 SERPINA3 CR2 CR1 CD1E CD1C CD1B
2 histiocytic sarcoma 30.8 CD68 CD163
3 rosai-dorfman disease 30.5 CR2 CD163
4 juvenile xanthogranuloma 30.4 SERPINA3 CD1E CD1A
5 langerhans cell sarcoma 30.2 CR2 CR1 CD68 CD207 CD1E CD1D
6 follicular dendritic cell sarcoma 30.1 CR2 CR1 CLU CD68
7 dendritic cell tumor 29.8 PTPRC CR2 CR1 CD68 CD207 CD1A
8 langerhans cell histiocytosis 29.7 PTPRC CD68 CD207 CD1C CD1A CD163
9 erdheim-chester disease 29.6 SERPINA3 CD1E CD1D CD1C CD1B CD1A
10 anaplastic large cell lymphoma 29.4 TNFRSF8 PTPRC CLU
11 histiocytosis 29.3 TNFRSF8 SERPINA3 PTPRC CD207 CD1C CD1A
12 histiocytic and dendritic cell tumor 11.3
13 blastic plasmacytoid dendritic cell 10.4
14 parapharyngeal meningioma 10.4 CR2 CR1
15 predominantly cortical thymoma 10.3 CD1E CD1A
16 tolosa-hunt syndrome 10.3 CD1E CD1A
17 endobronchial leiomyoma 10.3 CR2 CR1
18 dendritic cell thymoma 10.3 CD1E CD1A
19 multifocal motor neuropathy 10.3 CD1E CD1A
20 alk+ histiocytosis 10.3 CD207 CD1A
21 pityriasis rosea 10.3 CD1E CD1A
22 kimura disease 10.3 CD1E CD1A
23 skin sarcoidosis 10.3 CD1C CD1B
24 granulomatous orchitis 10.3 CD68 CD1E
25 oral hairy leukoplakia 10.2 CR2 CD1E CD1A
26 retroperitoneal lymphoma 10.2 TNFRSF8 CD1E
27 cerebellopontine angle primitive neuroectodermal tumor 10.2 PTPRC CR2
28 mixed type thymoma 10.2 CD1E CD1B CD1A
29 encapsulated thymoma 10.2 CD1E CD1B CD1A
30 sphenoid sinusitis 10.2 CD1E CD1B CD1A
31 epithelial malignant thymoma 10.2 CD1E CD1B CD1A
32 actinobacillosis 10.2 CR2 CD68
33 diffuse large b-cell lymphoma 10.2
34 b-cell lymphoma 10.2
35 monocytic leukemia 10.2
36 granulomatous gastritis 10.2 CR2 CR1 CD68
37 congenital epulis 10.2 SERPINA3 CD68
38 epulis 10.2 SERPINA3 CD68
39 verruciform xanthoma of skin 10.2 SERPINA3 CD68
40 proliferative fasciitis 10.1 SERPINA3 CD68
41 malignant inflammatory fibrous histiocytoma 10.1 SERPINA3 CD68
42 pancreas sarcoma 10.1 SERPINA3 CD68
43 xanthogranulomatous pyelonephritis 10.1 SERPINA3 CD68
44 sarcomatoid squamous cell skin carcinoma 10.1 SERPINA3 CD68
45 villonodular synovitis 10.1 PTPRC CD68
46 cobblestone retinal degeneration 10.1 PTPRC CD68
47 malignant granular cell myoblastoma 10.1 SERPINA3 CD68
48 liver sarcoma 10.1 SERPINA3 CD68
49 pleomorphic lipoma 10.1 SERPINA3 CD68
50 inflammatory myofibroblastic tumor 10.1 CR2 CR1 CD68

Graphical network of the top 20 diseases related to Histiocytic and Dendritic Cell Cancer:



Diseases related to Histiocytic and Dendritic Cell Cancer

Symptoms & Phenotypes for Histiocytic and Dendritic Cell Cancer

Drugs & Therapeutics for Histiocytic and Dendritic Cell Cancer

Search Clinical Trials , NIH Clinical Center for Histiocytic and Dendritic Cell Cancer

Genetic Tests for Histiocytic and Dendritic Cell Cancer

Anatomical Context for Histiocytic and Dendritic Cell Cancer

MalaCards organs/tissues related to Histiocytic and Dendritic Cell Cancer:

40
Myeloid, Eye, Lymph Node, Spleen, Tonsil, Endothelial

Publications for Histiocytic and Dendritic Cell Cancer

Articles related to Histiocytic and Dendritic Cell Cancer:

(show all 43)
# Title Authors PMID Year
1
Myeloid, mast cell, histiocytic and dendritic cell neoplasms and proliferations involving the spleen. 61
33012564 2021
2
Ionized Calcium Binding Adaptor Molecule 1 (IBA1): A Novel, Highly Sensitive, and Specific Marker for Histiocytic, Dendritic, and Monocytic Neoplasms. 61
33582751 2021
3
Atypical cutaneous histiocytic eruption in a patient with chronic myelomonocytic leukemia: A case report. 61
33416192 2021
4
Histiocytic and dendritic cell neoplasms: Reappraisal of a Japanese series based on t(14;18) and neoplastic PD-L1 expression. 61
33238073 2021
5
Extranodal Follicular Dendritic Cell Sarcoma-A Review: "What the Mind Does Not Know the Eye Does Not See". 61
32991350 2021
6
Descriptive Analysis of Histiocytic and Dendritic Cell Neoplasms: A Single-Institution Experience. 61
32882761 2020
7
Histiocytic Sarcoma. 61
31070934 2020
8
Histiocytic and Dendritic Cell Neoplasms. 61
31352989 2019
9
[Clinicopathological characteristics and differential diagnosis of interdigitating dendritic cell sarcoma]. 61
31216832 2019
10
Synchronous case of follicular lymphoma and Langerhans cell sarcoma in the same lymph node. 61
30255584 2018
11
[Histiocytic and dendritic cell neoplasms: Review of the literature]. 61
30012309 2018
12
Interdigitating dendritic cell sarcoma: Clinicopathologic study of 8 cases with review of the literature. 61
29660568 2018
13
The t(14;18) translocation is absent from endothelial and follicular dendritic cells of follicular lymphoma (FL) and shows heterogeneous presence in preserved FL mantle zones. 61
29720207 2018
14
Expression of enhancer of zeste homolog 2 (EZH2) protein in histiocytic and dendritic cell neoplasms with evidence for p-ERK1/2-related, but not MYC- or p-STAT3-related cell signaling. 61
29327713 2018
15
Applicability of 2008 World Health Organization classification system of hematolymphoid neoplasms: Learning experiences. 61
29567885 2018
16
Non-neoplastic histiocytic and dendritic cell disorders in lymph nodes. 61
29150219 2018
17
Histiocytic and dendritic cell neoplasms: A case series of 24 patients. 61
28923676 2017
18
Prognostic factors for histiocytic and dendritic cell neoplasms. 61
29228722 2017
19
Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases. 61
28695297 2017
20
Erdheim-Chester Disease: Comprehensive Review of Molecular Profiling and Therapeutic Advances. 61
28551613 2017
21
Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms. 61
28133975 2017
22
High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms. 61
27823979 2016
23
Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders. 61
26752545 2016
24
Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis. 61
27980300 2016
25
Impact of surgery, radiation and systemic therapy on the outcomes of patients with dendritic cell and histiocytic sarcomas. 61
26298731 2015
26
Follicular Dendritic Cell Sarcoma: Cytogenetics and pathological findings. 61
26355964 2015
27
Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma. 61
25787243 2015
28
Clinicopathologic characteristics and outcomes of histiocytic and dendritic cell neoplasms: the moffitt cancer center experience over the last twenty five years. 61
25405526 2014
29
Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms. 61
24720374 2014
30
Follicular dendritic cell sarcoma of the tonsil. 61
23365157 2013
31
Incidence, survival and prevalence of myeloid malignancies in Europe. 61
22770878 2012
32
Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases. 61
21666687 2011
33
Histiocytic and Dendritic Cell Neoplasms. 61
26839303 2010
34
The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms. 61
20656318 2010
35
Langerhans cell histiocytosis of the parietal bone with epidural and extracranial expansion - case report and a review of the literature. 61
20496290 2010
36
[Immunodeficiency-associated lymphoproliferative disorders, histiocytic and dendritic cell neoplasms]. 61
19404019 2009
37
Metastatic interdigitating dendritic cell sarcoma masquerading as a skin primary tumor: a case report and review of the literature. 61
19155734 2009
38
[Interdigitating dendritic cell sarcoma/tumor: a study of 3 cases]. 61
19094486 2008
39
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. 61
18272816 2008
40
Dendritic cell neoplasms: an overview. 61
17636477 2007
41
Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. 61
17373675 2007
42
[Malignant lymphomas of the liver: new diagnostic algorithms]. 61
16758166 2006
43
[Classification of neoplastic disorders of the haematopoietic system]. 61
15018389 2004

Variations for Histiocytic and Dendritic Cell Cancer

Expression for Histiocytic and Dendritic Cell Cancer

Search GEO for disease gene expression data for Histiocytic and Dendritic Cell Cancer.

Pathways for Histiocytic and Dendritic Cell Cancer

GO Terms for Histiocytic and Dendritic Cell Cancer

Cellular components related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.25 TNFRSF8 PTPRC CR2 CR1 CLU CD68
2 plasma membrane GO:0005886 10.14 TNFRSF8 PTPRC CR2 CR1 CD68 CD207
3 extracellular space GO:0005615 10.02 SERPINA3 CLU CD1E CD1D CD1C CD1B
4 integral component of membrane GO:0016021 9.93 TNFRSF8 PTPRC CR2 CR1 CD68 CD207
5 integral component of plasma membrane GO:0005887 9.91 PTPRC CR1 CD1E CD1D CD1C CD1A
6 cell surface GO:0009986 9.85 PTPRC CR1 CLU CD1D CD1B
7 endosome GO:0005768 9.73 CD68 CD1E CD1D CD1C CD1B CD1A
8 lysosome GO:0005764 9.72 CD68 CD1E CD1D CD1C CD1B
9 endosome membrane GO:0010008 9.35 CD68 CD1D CD1C CD1B CD1A
10 external side of plasma membrane GO:0009897 9.17 PTPRC CD1E CD1D CD1C CD1B CD1A

Biological processes related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.86 CR2 CR1 CLU CD1E CD1D CD1C
2 neutrophil degranulation GO:0043312 9.83 SERPINA3 PTPRC CR1 CD68
3 adaptive immune response GO:0002250 9.81 CD1E CD1C CD1B CD1A
4 immune response GO:0006955 9.8 CR2 CD1E CD1D CD1C CD1B CD1A
5 complement activation, classical pathway GO:0006958 9.67 CR2 CR1 CLU
6 regulation of immune response GO:0050776 9.67 CD1D CD1C CD1B CD1A
7 regulation of complement activation GO:0030449 9.63 CR2 CR1 CLU
8 positive regulation of tumor necrosis factor production GO:0032760 9.58 TNFRSF8 PTPRC CLU
9 heterotypic cell-cell adhesion GO:0034113 9.55 PTPRC CD1D
10 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.55 CD1E CD1D CD1C CD1B CD1A
11 negative regulation of interleukin-2 production GO:0032703 9.54 PTPRC CR1
12 complement activation, alternative pathway GO:0006957 9.48 CR2 CR1
13 complement receptor mediated signaling pathway GO:0002430 9.43 CR2 CR1
14 positive regulation of T cell mediated cytotoxicity GO:0001916 9.43 PTPRC CD1E CD1D CD1C CD1B CD1A
15 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Histiocytic and Dendritic Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Histiocytic and Dendritic Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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