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MCID: HST016
MIFTS: 34

Histiocytic Sarcoma

Categories: Cancer diseases, Blood diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Histiocytic Sarcoma

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MalaCards integrated aliases for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 59 73

Characteristics:

Orphanet epidemiological data:

59
histiocytic sarcoma
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34 33
Orphanet: 59  
Rare haematological diseases


External Ids:

Orphanet 59 ORPHA86896
MESH via Orphanet 45 D054747
UMLS via Orphanet 74 C0334663
ICD10 via Orphanet 34 C96.8
ICD10 33 C96.8
UMLS 73 C0334663
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Summaries for Histiocytic Sarcoma

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MalaCards based summary : Histiocytic Sarcoma is related to papillary carcinoma and malignant histiocytosis. An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Dendritic Cells Developmental Lineage Pathway. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and bone.

Wikipedia : 76 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

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Related Diseases for Histiocytic Sarcoma

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Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 papillary carcinoma 28.4 LGALS3 MUC1
2 malignant histiocytosis 11.5
3 reticulosarcoma 11.1
4 sarcoma 11.0
5 lymphoma 10.3
6 leukemia 10.3
7 leukemia, acute lymphoblastic 10.2
8 lymphoblastic leukemia 10.2
9 histiocytosis 10.1
10 follicular lymphoma 10.1
11 thyroiditis 10.1
12 hematopoietic stem cell transplantation 10.0
13 thrombocytopenia 10.0
14 b-cell lymphomas 10.0
15 mediastinitis 9.9
16 cerebritis 9.9
17 hemolytic anemia 9.9
18 hepatitis 9.9
19 meningitis 9.9
20 germ cells tumors 9.9
21 langerhans cell histiocytosis 9.9
22 glioma 9.9
23 chronic myelomonocytic leukemia 9.9
24 pdgfrb-associated chronic eosinophilic leukemia 9.9
25 diffuse large b-cell lymphoma 9.9
26 rosai-dorfman disease 9.9
27 mucinous bronchioloalveolar adenocarcinoma 9.8 LGALS3 MUC1
28 esophagitis 9.7
29 spastic paraparesis 9.7
30 leukemia, acute monocytic 9.7
31 glomerulonephritis 9.7
32 prostatitis 9.7
33 interdigitating dendritic cell sarcoma 9.7
34 splenomegaly 9.7
35 muir-torre syndrome 9.7
36 pneumothorax 9.7
37 syndrome of inappropriate antidiuretic hormone 9.7
38 myelopathy, htlv-1-associated 9.7
39 duodenal ulcer 9.7
40 monocytic leukemia 9.7
41 paraneoplastic syndromes 9.7
42 pneumothorax, primary spontaneous 9.7
43 melanoma 9.7
44 spasticity 9.7
45 small cell cancer of the lung 9.7
46 cervicitis 9.7
47 ascites, chylous 9.7
48 mantle cell lymphoma 9.7
49 hairy cell leukemia 9.7
50 duodenitis 9.7

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to Histiocytic Sarcoma
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Symptoms & Phenotypes for Histiocytic Sarcoma

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Drugs & Therapeutics for Histiocytic Sarcoma

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Drugs for Histiocytic Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Pembrolizumab Approved Phase 2 1374853-91-4
4
Olaparib Approved Phase 2 763113-22-0 23725625
5
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
6
Lenalidomide Approved Phase 2 191732-72-6 216326
7 Anti-Infective Agents Phase 2,Not Applicable
8 Anti-Bacterial Agents Phase 2
9 Antibiotics, Antitubercular Phase 2
10 Antibodies Phase 2
11 Immunoglobulins Phase 2
12 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
13 Immunosuppressive Agents Phase 2
14 Antifungal Agents Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 tyrosine Nutraceutical Phase 2
18
Zidovudine Approved Not Applicable 30516-87-1 35370
19 Reverse Transcriptase Inhibitors Not Applicable
20 Nucleic Acid Synthesis Inhibitors Not Applicable
21 Anti-HIV Agents Not Applicable
22 Anti-Retroviral Agents Not Applicable
23 Antimetabolites Not Applicable
24 Antiviral Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Pembrolizumab in Patients With Histiocyte/Dendritic Cell Neoplasms and Biologically Selected Subtypes of Relapsed/Refractory Aggressive Lymphomas Recruiting NCT03316573 Phase 2 Pembrolizumab
2 Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) Recruiting NCT03155620 Phase 2 Ensartinib;Erdafitinib;Larotrectinib;Olaparib;Palbociclib;PI3K/mTOR Inhibitor LY3023414;Selumetinib Sulfate;Tazemetostat;Vemurafenib
3 A Study of Lenalidomide for Adult Histiocyte Disorders Active, not recruiting NCT02523040 Phase 2 Lenalidomide
4 A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow Transplant Completed NCT00002284 Not Applicable Zidovudine

Search NIH Clinical Center for Histiocytic Sarcoma

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Genetic Tests for Histiocytic Sarcoma

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Anatomical Context for Histiocytic Sarcoma

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MalaCards organs/tissues related to Histiocytic Sarcoma:

41
Brain, Thyroid, Bone, Bone Marrow, B Cells, Spleen, Testes
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Publications for Histiocytic Sarcoma

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Articles related to Histiocytic Sarcoma:

(show top 50) (show all 306)
# Title Authors Year
1
Primary mediastinal histiocytic sarcoma presenting as pleural effusion. ( 29756323 )
2018
2
Simultaneous Brain and Lung Histiocytic Sarcoma Revealed on 18F-FDG PET/CT. ( 29189378 )
2018
3
Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers. ( 29275293 )
2018
4
Histiocytic sarcoma of the neck: A case report. ( 29977539 )
2018
5
Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome. ( 29850341 )
2018
6
Extranodal histiocytic sarcoma in a child with acute lymphoblastic leukemia: Cytomorphological features of a rare entity with brief review of literature. ( 29676378 )
2018
7
Primary cutaneous histiocytic sarcoma: A report of five cases with primary cutaneous involvement and review of the literature. ( 29414400 )
2018
8
A Case Report of Disseminated Canine Histiocytic Sarcoma in Trinidad and Tobago. ( 29351196 )
2018
9
Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? ( 29515976 )
2018
10
Histiocytic sarcoma in a child-successful management and long-term survival with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. ( 29630764 )
2018
11
Would you think of histiocytic sarcoma in this fine-needle aspiration? ( 29728735 )
2018
12
Histiocytic sarcoma with bladder involvement: Case report and literature review. ( 29290317 )
2018
13
Response to MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma. ( 29097496 )
2018
14
Primary central nervous system histiocytic sarcoma: A case report and review of literature. ( 29953002 )
2018
15
Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes. ( 29183888 )
2018
16
Molecular characteristics of multifocal brain histiocytic sarcoma. ( 29679510 )
2018
17
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies. ( 29490634 )
2018
18
Trametinib in Histiocytic Sarcoma with an Activating MAP2K1 (MEK1) Mutation. ( 29768143 )
2018
19
Establishment and characterization of a cell line from a feline histiocytic sarcoma. ( 29914686 )
2018
20
Retroperitoneal Bulky Histiocytic Sarcoma Successfully Treated with Induction Chemotherapy Followed by Curative Surgery. ( 28924109 )
2017
21
Efficacy of dacarbazine as a rescue agent for histiocytic sarcoma in dogs. ( 28419676 )
2017
22
Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2. ( 28833247 )
2017
23
Canine histiocytic sarcoma presenting as a target lesion on brain magnetic resonance imaging and as a solitary pulmonary mass. ( 28419635 )
2017
24
Infection or Glioma? The False Dilemma of Primary Central Nervous System Histiocytic Sarcoma. ( 28711535 )
2017
25
Disseminated histiocytic sarcoma with hemophagocytosis in a rabbit. ( 28740033 )
2017
26
Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient. ( 28087030 )
2017
27
Histiocytic Sarcoma with p16-Overexpression Presenting as Uterine Cervical Mass. ( 29263052 )
2017
28
Invasive histiocytic sarcoma of the lumbar spine in a ferret (Mustela putorius furo). ( 28160308 )
2017
29
BRAF (V600E) expression in histiocytic sarcoma associated with splenic marginal zone lymphoma: a case report. ( 28376906 )
2017
30
Histiocytic sarcoma in 14 miniature schnauzers - a new breed predisposition? ( 28543363 )
2017
31
Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. ( 28621004 )
2017
32
Syndrome of inappropriate antidiuretic hormone secretion in a dog with a histiocytic sarcoma. ( 28698689 )
2017
33
A 2-base insertion in exon 5 is a common mutation of the TP53 gene in dogs with histiocytic sarcoma. ( 28867679 )
2017
34
Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics. ( 28805986 )
2017
35
Prior joint disease is associated with increased risk of periarticular histiocytic sarcoma in dogs. ( 28836371 )
2017
36
Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog. ( 28381106 )
2017
37
Primary histiocytic sarcoma presenting as diffuse leptomeningeal disease: Case description and review of the literature. ( 28548244 )
2017
38
Cutaneous Manifestation of Histiocytic Sarcoma: Presentation and Management. ( 28958257 )
2017
39
Comparisons among MRI signs, apparent diffusion coefficient, and fractional anisotropy in dogs with a solitary intracranial meningioma or histiocytic sarcoma. ( 28335080 )
2017
40
Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child. ( 28247189 )
2017
41
Pediatric intracerebral histiocytic sarcoma with rhabdoid features: Case report and literature review. ( 28748542 )
2017
42
Primary Histiocytic Sarcoma of the Brain in an African Hedgehog (Atelerix albiventris). ( 29169617 )
2017
43
Histiocytic sarcoma: secondary neoplasm or "transdifferentiation" in the setting of B-acute lymphoblastic leukemia. ( 27856472 )
2016
44
Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation. ( 27429816 )
2016
45
Persistent Morbillivirus Infection Leads to Altered Cortactin Distribution in Histiocytic Sarcoma Cells with Decreased Cellular Migration Capacity. ( 27911942 )
2016
46
Disseminated Histiocytic Sarcoma in an African Hedgehog (Atelerix albiventris). ( 27720131 )
2016
47
SYSTEMIC HISTIOCYTIC SARCOMA IN A COMMON HIPPOPOTAMUS (HIPPOPOTAMUS AMPHIBIUS). ( 27468044 )
2016
48
Risk Factors Associated with Development of Histiocytic Sarcoma in Bernese Mountain Dogs. ( 27160025 )
2016
49
Two cases of histiocytic sarcoma with BCL2 translocations and occult or subsequent follicular lymphoma. ( 27134111 )
2016
50
High-dose methotrexate-based chemotherapy as treatment for histiocytic sarcoma of the central nervous system. ( 26727454 )
2016
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Variations for Histiocytic Sarcoma

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Expression for Histiocytic Sarcoma

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Search GEO for disease gene expression data for Histiocytic Sarcoma.
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Pathways for Histiocytic Sarcoma

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Pathways related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.22 CD163 MS4A1
2
Dendritic Cells Developmental Lineage Pathway 65
10.82 CD163 MS4A1
3
Cell adhesion_Cell-matrix glycoconjugates 22
10.21 LGALS3 MUC1
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GO Terms for Histiocytic Sarcoma

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Sources for Histiocytic Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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