MCID: HST016
MIFTS: 26

Histiocytic Sarcoma

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

MalaCards integrated aliases for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 60 74

Characteristics:

Orphanet epidemiological data:

60
histiocytic sarcoma
Age of onset: Adult;

Classifications:



External Ids:

ICD10 34 C96.8
MESH via Orphanet 46 D054747
ICD10 via Orphanet 35 C96.8
UMLS via Orphanet 75 C0334663
Orphanet 60 ORPHA86896
UMLS 74 C0334663

Summaries for Histiocytic Sarcoma

MalaCards based summary : Histiocytic Sarcoma is related to histiocytosis and interdigitating dendritic cell sarcoma. An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule). Affiliated tissues include brain, thyroid and b cells.

Wikipedia : 77 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

Related Diseases for Histiocytic Sarcoma

Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 30.2 BRAF CD163
2 interdigitating dendritic cell sarcoma 29.8 CD163 CR1
3 langerhans cell histiocytosis 29.7 BRAF CD163
4 histiocytic and dendritic cell cancer 29.6 CD163 CR1
5 malignant histiocytosis 11.7
6 reticulosarcoma 11.2
7 sarcoma 11.1
8 spindle cell sarcoma 10.5
9 lymphoma 10.5
10 leukemia 10.4
11 leukemia, acute lymphoblastic 10.3
12 lymphocytic leukemia 10.3
13 follicular lymphoma 10.3
14 b-cell lymphomas 10.2
15 thrombocytopenia 10.1
16 chronic myelomonocytic leukemia 10.0
17 diffuse large b-cell lymphoma 10.0
18 hematopoietic stem cell transplantation 10.0
19 hemolytic anemia 10.0
20 germ cells tumors 10.0
21 glioma 10.0
22 pdgfrb-associated chronic eosinophilic leukemia 10.0
23 rosai-dorfman disease 10.0
24 langerhans cell sarcoma 10.0 CD163 CR1
25 non-langerhans-cell histiocytosis 9.9 BRAF CD163
26 breast cancer 9.8
27 leukemia, acute monocytic 9.8
28 muir-torre syndrome 9.8
29 myelopathy, htlv-1-associated 9.8
30 pneumothorax, primary spontaneous 9.8
31 small cell cancer of the lung 9.8
32 ascites, chylous 9.8
33 lung cancer 9.8
34 myelofibrosis 9.8
35 reticulum cell sarcoma 9.8
36 aging 9.8
37 autoimmune lymphoproliferative syndrome 9.8
38 acute lymphoblastic leukemia, childhood 9.8
39 glomerulonephritis 9.8
40 mantle cell lymphoma 9.8
41 splenic marginal zone lymphoma 9.8
42 temporal lobe epilepsy 9.8
43 lymphoproliferative syndrome 9.8
44 thrombosis 9.8
45 chronic meningitis 9.8
46 pneumothorax 9.8
47 thyroid cancer 9.8
48 epilepsy 9.8
49 melanoma 9.8
50 hairy cell leukemia 9.8

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to Histiocytic Sarcoma

Symptoms & Phenotypes for Histiocytic Sarcoma

Drugs & Therapeutics for Histiocytic Sarcoma

Search Clinical Trials , NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

Anatomical Context for Histiocytic Sarcoma

MalaCards organs/tissues related to Histiocytic Sarcoma:

42
Brain, Thyroid, B Cells, Spleen, Bone, Bone Marrow, Lymph Node

Publications for Histiocytic Sarcoma

Articles related to Histiocytic Sarcoma:

(show top 50) (show all 338)
# Title Authors Year
1
Histiocytic Sarcoma Associated With Follicular Lymphoma: Evidence for Dramatic Response With Rituximab and Bendamustine Alone and a Review of the Literature. ( 30396823 )
2019
2
Favorable response to nivolumab in a young adult patient with metastatic histiocytic sarcoma. ( 30270506 )
2019
3
Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma. ( 30626916 )
2019
4
The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma. ( 30662044 )
2019
5
Development of an Orthotopic Intrasplenic Xenograft Mouse Model of Canine Histiocytic Sarcoma and Its Use in Evaluating the Efficacy of Treatment with Dasatinib. ( 30717820 )
2019
6
Clinical management and outcome of four-toed hedgehogs (Atelerix albiventris) with histiocytic sarcoma. ( 30760662 )
2019
7
Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells. ( 30761736 )
2019
8
Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma. ( 30852355 )
2019
9
Cancer-Testis Antigens in Canine Histiocytic Sarcoma and Other Malignancies. ( 30854786 )
2019
10
Primary mediastinal histiocytic sarcoma presenting as pleural effusion. ( 29756323 )
2018
11
Simultaneous Brain and Lung Histiocytic Sarcoma Revealed on 18F-FDG PET/CT. ( 29189378 )
2018
12
Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers. ( 29275293 )
2018
13
Comment on "MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma". ( 29491129 )
2018
14
Histiocytic sarcoma of the neck: A case report. ( 29977539 )
2018
15
Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome. ( 29850341 )
2018
16
Extranodal histiocytic sarcoma in a child with acute lymphoblastic leukemia: Cytomorphological features of a rare entity with brief review of literature. ( 29676378 )
2018
17
Primary cutaneous histiocytic sarcoma: A report of five cases with primary cutaneous involvement and review of the literature. ( 29414400 )
2018
18
A Case Report of Disseminated Canine Histiocytic Sarcoma in Trinidad and Tobago. ( 29351196 )
2018
19
Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? ( 29515976 )
2018
20
Histiocytic sarcoma in a child-successful management and long-term survival with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. ( 29630764 )
2018
21
Would you think of histiocytic sarcoma in this fine-needle aspiration? ( 29728735 )
2018
22
Histiocytic sarcoma with bladder involvement: Case report and literature review. ( 29290317 )
2018
23
Response to MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma. ( 29097496 )
2018
24
Primary central nervous system histiocytic sarcoma: A case report and review of literature. ( 29953002 )
2018
25
Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes. ( 29183888 )
2018
26
Molecular characteristics of multifocal brain histiocytic sarcoma. ( 29679510 )
2018
27
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies. ( 29490634 )
2018
28
Trametinib in Histiocytic Sarcoma with an Activating MAP2K1 (MEK1) Mutation. ( 29768143 )
2018
29
Establishment and characterization of a cell line from a feline histiocytic sarcoma. ( 29914686 )
2018
30
Invasive nasal histiocytic sarcoma as a cause of temporal lobe epilepsy in a cat. ( 30450218 )
2018
31
Predictors of survival, treatment patterns, and outcomes in histiocytic sarcoma. ( 30032691 )
2018
32
Targeting MEK in a Translational Model of Histiocytic Sarcoma. ( 30135215 )
2018
33
Case of primary central nervous system histiocytic sarcoma with prominent proliferation of histiocytic cells between the trabeculae of reactive glial cells. ( 30155921 )
2018
34
Primary histiocytic sarcoma of the central nervous system: a case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review. ( 30185195 )
2018
35
Primary pulmonary histiocytic sarcoma in dogs: A retrospective analysis of 37 cases (2000-2015). ( 30246460 )
2018
36
Bone marrow infiltration of histiocytic sarcoma. ( 30310780 )
2018
37
A Rare Case of Primary Histiocytic Sarcoma of the Stomach. ( 30355826 )
2018
38
A case of recurrent histiocytic sarcoma with MAP2K1 pathogenic variant treated with the MEK inhibitor trametinib. ( 30361829 )
2018
39
Orbital Apex Syndrome in a Patient With Histiocytic Sarcoma. ( 30398544 )
2018
40
Histiocytic Sarcoma: Review, Discussion of Transformation From B-Cell Lymphoma, and Differential Diagnosis. ( 30407858 )
2018
41
Lomustine chemotherapy for the treatment of presumptive haemophagocytic histiocytic sarcoma in Flat-coated Retrievers. ( 30478839 )
2018
42
In this issue - December 2018: Pro bono wildlife work in Australian veterinary practices · Roaming owned dogs in Northern Australia · Snake stomach recovers after gastrectomy · Metronidazole-induced neurotoxicity in 26 dogs · Lomustine ineffective for haemophagocytic histiocytic sarcoma · Surgical swabs and dehorning wounds. ( 30478841 )
2018
43
An unexpected diagnosis of histiocytic sarcoma. ( 30502322 )
2018
44
Putative histiocytic sarcoma in redfin needlefish Strongylura notata (Beloniformes: Belonidae) in Florida, USA. ( 30530931 )
2018
45
Retroperitoneal Bulky Histiocytic Sarcoma Successfully Treated with Induction Chemotherapy Followed by Curative Surgery. ( 28924109 )
2017
46
Efficacy of dacarbazine as a rescue agent for histiocytic sarcoma in dogs. ( 28419676 )
2017
47
Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2. ( 28833247 )
2017
48
Canine histiocytic sarcoma presenting as a target lesion on brain magnetic resonance imaging and as a solitary pulmonary mass. ( 28419635 )
2017
49
Infection or Glioma? The False Dilemma of Primary Central Nervous System Histiocytic Sarcoma. ( 28711535 )
2017
50
Disseminated histiocytic sarcoma with hemophagocytosis in a rabbit. ( 28740033 )
2017

Variations for Histiocytic Sarcoma

Expression for Histiocytic Sarcoma

Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for Histiocytic Sarcoma

GO Terms for Histiocytic Sarcoma

Sources for Histiocytic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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