MCID: HST016
MIFTS: 38

Histiocytic Sarcoma

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

MalaCards integrated aliases for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 60 74

Characteristics:

Orphanet epidemiological data:

60
histiocytic sarcoma
Age of onset: Adult;

Classifications:



External Ids:

ICD10 34 C96.8
MESH via Orphanet 46 D054747
ICD10 via Orphanet 35 C96.8
UMLS via Orphanet 75 C0334663
Orphanet 60 ORPHA86896
UMLS 74 C0334663

Summaries for Histiocytic Sarcoma

MalaCards based summary : Histiocytic Sarcoma is related to histiocytosis and langerhans cell histiocytosis. An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include brain, thyroid and b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

Related Diseases for Histiocytic Sarcoma

Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 30.5 BRAF CD163
2 langerhans cell histiocytosis 29.8 BRAF CD163 CSF1
3 mantle cell lymphoma 29.2 BCL2 CDKN2A
4 glioma 29.2 BCL2 BRAF CDKN2A
5 malignant histiocytosis 11.7
6 reticulosarcoma 11.3
7 sarcoma 11.1
8 spindle cell sarcoma 10.8
9 lymphoma 10.5
10 leukemia 10.4
11 leukemia, acute lymphoblastic 10.3
12 lymphocytic leukemia 10.3
13 follicular lymphoma 10.3
14 acute lymphocytic leukemia 10.1
15 thrombocytopenia 10.1
16 brain sarcoma 10.1
17 meningioma, familial 10.1
18 spinal meningioma 10.1
19 secretory meningioma 10.1
20 non-langerhans-cell histiocytosis 10.1 BRAF CD163
21 spondylarthropathy 10.0 CD163 CSF1
22 chronic myelomonocytic leukemia 10.0
23 diffuse large b-cell lymphoma 10.0
24 hematopoietic stem cell transplantation 10.0
25 hemolytic anemia 10.0
26 germ cells tumors 10.0
27 pdgfrb-associated chronic eosinophilic leukemia 10.0
28 polymorphic reticulosis 10.0
29 rosai-dorfman disease 10.0
30 bladder squamous cell carcinoma 10.0 BRAF CDKN2A
31 spitz nevus 10.0 BRAF CDKN2A
32 tenosynovial giant cell tumor 10.0 CDKN2A CSF1
33 acral lentiginous melanoma 10.0 BRAF CDKN2A
34 skin melanoma 9.9 BRAF CDKN2A
35 melanoma, uveal 9.9 BRAF CDKN2A
36 breast cancer 9.8
37 leukemia, acute monocytic 9.8
38 muir-torre syndrome 9.8
39 myelopathy, htlv-1-associated 9.8
40 small cell cancer of the lung 9.8
41 ascites, chylous 9.8
42 lung cancer 9.8
43 myelofibrosis 9.8
44 reticulum cell sarcoma 9.8
45 aging 9.8
46 autoimmune lymphoproliferative syndrome 9.8
47 acute lymphoblastic leukemia, childhood 9.8
48 brain meningioma 9.8
49 glomerulonephritis 9.8
50 marginal zone b-cell lymphoma 9.8

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to Histiocytic Sarcoma

Symptoms & Phenotypes for Histiocytic Sarcoma

GenomeRNAi Phenotypes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

27 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-106 10.06 BCL2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.06 BRAF
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.06 CSF1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.06 BCL2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.06 BCL2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.06 CD163
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.06 CD163
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.06 BRAF CD163 CSF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.06 BCL2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.06 BRAF
11 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.06 CSF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.06 BCL2 BRAF CD163
13 Increased shRNA abundance (Z-score > 2) GR00366-A-194 10.06 BCL2 BRAF
14 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.06 CSF1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.06 BCL2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 10.06 BCL2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.06 BRAF
18 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.06 BRAF
19 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.06 BRAF
20 Increased shRNA abundance (Z-score > 2) GR00366-A-37 10.06 BCL2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.06 BRAF CSF1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.06 CD163
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.06 BCL2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.06 CD163
25 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.06 CD163
26 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.06 CD163
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.06 BCL2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-88 10.06 BCL2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.06 CD163
30 Increased shRNA abundance (Z-score > 2) GR00366-A-90 10.06 CSF1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-96 10.06 BCL2

MGI Mouse Phenotypes related to Histiocytic Sarcoma:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 BCL2 BRAF CD163 CDKN2A CSF1
2 cellular MP:0005384 9.89 BCL2 BRAF CD163 CDKN2A CSF1
3 hematopoietic system MP:0005397 9.85 BCL2 BRAF CD163 CDKN2A CSF1
4 homeostasis/metabolism MP:0005376 9.83 BCL2 BRAF CD163 CDKN2A CSF1
5 immune system MP:0005387 9.8 BCL2 BRAF CD163 CDKN2A CSF1
6 endocrine/exocrine gland MP:0005379 9.78 BCL2 BRAF CDKN2A CSF1
7 muscle MP:0005369 9.72 BCL2 BRAF CD163 CDKN2A CSF1
8 integument MP:0010771 9.67 BCL2 BRAF CDKN2A CSF1
9 reproductive system MP:0005389 9.46 BCL2 BRAF CDKN2A CSF1
10 pigmentation MP:0001186 9.43 BCL2 BRAF CDKN2A
11 respiratory system MP:0005388 9.26 BRAF CD163 CDKN2A CSF1
12 vision/eye MP:0005391 9.02 BCL2 BRAF CD163 CDKN2A CSF1

Drugs & Therapeutics for Histiocytic Sarcoma

Search Clinical Trials , NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

Anatomical Context for Histiocytic Sarcoma

MalaCards organs/tissues related to Histiocytic Sarcoma:

42
Brain, Thyroid, B Cells, Bone, Lung, Monocytes, Spleen

Publications for Histiocytic Sarcoma

Articles related to Histiocytic Sarcoma:

(show top 50) (show all 338)
# Title Authors Year
1
Histiocytic Sarcoma Associated With Follicular Lymphoma: Evidence for Dramatic Response With Rituximab and Bendamustine Alone and a Review of the Literature. ( 30396823 )
2019
2
Molecular characteristics of multifocal brain histiocytic sarcoma. ( 29679510 )
2019
3
Favorable response to nivolumab in a young adult patient with metastatic histiocytic sarcoma. ( 30270506 )
2019
4
A case of recurrent histiocytic sarcoma with MAP2K1 pathogenic variant treated with the MEK inhibitor trametinib. ( 30361829 )
2019
5
An unexpected diagnosis of histiocytic sarcoma. ( 30502322 )
2019
6
Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma. ( 30626916 )
2019
7
The intratumor heterogeneity of TP53 gene mutations in canine histiocytic sarcoma. ( 30662044 )
2019
8
Development of an Orthotopic Intrasplenic Xenograft Mouse Model of Canine Histiocytic Sarcoma and Its Use in Evaluating the Efficacy of Treatment with Dasatinib. ( 30717820 )
2019
9
Clinical management and outcome of four-toed hedgehogs (Atelerix albiventris) with histiocytic sarcoma. ( 30760662 )
2019
10
Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells. ( 30761736 )
2019
11
Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma. ( 30852355 )
2019
12
Cancer-Testis Antigens in Canine Histiocytic Sarcoma and Other Malignancies. ( 30854786 )
2019
13
Histiocytic Sarcoma. ( 31070934 )
2019
14
Invasive nasal histiocytic sarcoma as a cause of temporal lobe epilepsy in a cat. ( 30450218 )
2018
15
Canine histiocytic sarcoma presenting as a target lesion on brain magnetic resonance imaging and as a solitary pulmonary mass. ( 28419635 )
2018
16
Efficacy of dacarbazine as a rescue agent for histiocytic sarcoma in dogs. ( 28419676 )
2018
17
Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. ( 28621004 )
2018
18
Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2. ( 28833247 )
2018
19
Prior joint disease is associated with increased risk of periarticular histiocytic sarcoma in dogs. ( 28836371 )
2018
20
Response to MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma. ( 29097496 )
2018
21
Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes. ( 29183888 )
2018
22
Simultaneous Brain and Lung Histiocytic Sarcoma Revealed on 18F-FDG PET/CT. ( 29189378 )
2018
23
Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers. ( 29275293 )
2018
24
Histiocytic sarcoma with bladder involvement: Case report and literature review. ( 29290317 )
2018
25
A Case Report of Disseminated Canine Histiocytic Sarcoma in Trinidad and Tobago. ( 29351196 )
2018
26
Primary cutaneous histiocytic sarcoma: A report of five cases with primary cutaneous involvement and review of the literature. ( 29414400 )
2018
27
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies. ( 29490634 )
2018
28
Comment on "MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma". ( 29491129 )
2018
29
Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? ( 29515976 )
2018
30
Histiocytic sarcoma in a child-successful management and long-term survival with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. ( 29630764 )
2018
31
Extranodal histiocytic sarcoma in a child with acute lymphoblastic leukemia: Cytomorphological features of a rare entity with brief review of literature. ( 29676378 )
2018
32
Would you think of histiocytic sarcoma in this fine-needle aspiration? ( 29728735 )
2018
33
Primary mediastinal histiocytic sarcoma presenting as pleural effusion. ( 29756323 )
2018
34
Trametinib in Histiocytic Sarcoma with an Activating MAP2K1 (MEK1) Mutation. ( 29768143 )
2018
35
Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome. ( 29850341 )
2018
36
Establishment and characterization of a cell line from a feline histiocytic sarcoma. ( 29914686 )
2018
37
Primary central nervous system histiocytic sarcoma: A case report and review of literature. ( 29953002 )
2018
38
Histiocytic sarcoma of the neck: A case report. ( 29977539 )
2018
39
Predictors of survival, treatment patterns, and outcomes in histiocytic sarcoma. ( 30032691 )
2018
40
Targeting MEK in a Translational Model of Histiocytic Sarcoma. ( 30135215 )
2018
41
Case of primary central nervous system histiocytic sarcoma with prominent proliferation of histiocytic cells between the trabeculae of reactive glial cells. ( 30155921 )
2018
42
Primary histiocytic sarcoma of the central nervous system: a case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review. ( 30185195 )
2018
43
Primary pulmonary histiocytic sarcoma in dogs: A retrospective analysis of 37 cases (2000-2015). ( 30246460 )
2018
44
Bone marrow infiltration of histiocytic sarcoma. ( 30310780 )
2018
45
A Rare Case of Primary Histiocytic Sarcoma of the Stomach. ( 30355826 )
2018
46
Orbital Apex Syndrome in a Patient With Histiocytic Sarcoma. ( 30398544 )
2018
47
Histiocytic Sarcoma: Review, Discussion of Transformation From B-Cell Lymphoma, and Differential Diagnosis. ( 30407858 )
2018
48
Lomustine chemotherapy for the treatment of presumptive haemophagocytic histiocytic sarcoma in Flat-coated Retrievers. ( 30478839 )
2018
49
In this issue - December 2018: Pro bono wildlife work in Australian veterinary practices · Roaming owned dogs in Northern Australia · Snake stomach recovers after gastrectomy · Metronidazole-induced neurotoxicity in 26 dogs · Lomustine ineffective for haemophagocytic histiocytic sarcoma · Surgical swabs and dehorning wounds. ( 30478841 )
2018
50
Putative histiocytic sarcoma in redfin needlefish Strongylura notata (Beloniformes: Belonidae) in Florida, USA. ( 30530931 )
2018

Variations for Histiocytic Sarcoma

Expression for Histiocytic Sarcoma

Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for Histiocytic Sarcoma

Pathways related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 BCL2 BRAF CDKN2A
2 12.38 BCL2 BRAF CDKN2A
3
Show member pathways
12.16 BCL2 BRAF CDKN2A
4
Show member pathways
12.14 BCL2 BRAF CDKN2A
5 11.62 CD163 CSF1
6 11.61 BCL2 CDKN2A
7 11.58 BRAF CDKN2A
8 11.55 BCL2 BRAF
9 11.48 BCL2 BRAF
10 11.33 CD163 CSF1
11 11.3 BRAF CDKN2A
12 11.27 BCL2 CDKN2A
13 10.96 BCL2 CDKN2A
14 10.82 BCL2 BRAF CDKN2A
15 10.52 BCL2 BRAF
16
Show member pathways
10.3 BCL2 CDKN2A

GO Terms for Histiocytic Sarcoma

Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.5 BRAF CDKN2A CSF1
2 negative regulation of cell growth GO:0030308 9.48 BCL2 CDKN2A
3 animal organ morphogenesis GO:0009887 9.46 BCL2 BRAF
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.43 BCL2 BRAF
5 regulation of protein stability GO:0031647 9.4 BCL2 CDKN2A
6 hemopoiesis GO:0030097 9.37 BCL2 CSF1
7 thymus development GO:0048538 9.26 BCL2 BRAF
8 positive regulation of multicellular organism growth GO:0040018 9.16 BCL2 CSF1
9 homeostasis of number of cells within a tissue GO:0048873 8.96 BCL2 CSF1
10 apoptotic mitochondrial changes GO:0008637 8.62 BCL2 CDKN2A

Sources for Histiocytic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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