MCID: HST016
MIFTS: 36

Histiocytic Sarcoma

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Histiocytic Sarcoma

MalaCards integrated aliases for Histiocytic Sarcoma:

Name: Histiocytic Sarcoma 59 73

Characteristics:

Orphanet epidemiological data:

59
histiocytic sarcoma
Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA86896
MESH via Orphanet 45 D054747
UMLS via Orphanet 74 C0334663
ICD10 via Orphanet 34 C96.8
ICD10 33 C96.8
UMLS 73 C0334663

Summaries for Histiocytic Sarcoma

MalaCards based summary : Histiocytic Sarcoma is related to rosai-dorfman disease and reticulum cell sarcoma. An important gene associated with Histiocytic Sarcoma is CD163 (CD163 Molecule), and among its related pathways/superpathways are Complement and coagulation cascades and Immune response Lectin induced complement pathway. Affiliated tissues include brain, thyroid and b cells.

Wikipedia : 76 Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can... more...

Related Diseases for Histiocytic Sarcoma

Diseases related to Histiocytic Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 rosai-dorfman disease 30.0 CD163 CR2
2 reticulum cell sarcoma 29.5 CR1 CR2
3 interdigitating dendritic cell sarcoma 29.3 CD163 CR1 CR2
4 histiocytic and dendritic cell cancer 29.3 CD163 CR1 CR2
5 malignant histiocytosis 11.7
6 reticulosarcoma 11.2
7 sarcoma 11.1
8 spindle cell sarcoma 10.5
9 lymphoma 10.4
10 leukemia, acute lymphoblastic 10.3
11 leukemia 10.3
12 lymphocytic leukemia 10.3
13 follicular lymphoma 10.2
14 histiocytosis 10.2
15 b-cell lymphomas 10.2
16 thrombocytopenia 10.1
17 spleen cancer 10.0 CD163 CR2
18 langerhans cell histiocytosis 10.0
19 chronic myelomonocytic leukemia 10.0
20 diffuse large b-cell lymphoma 10.0
21 hematopoietic stem cell transplantation 10.0
22 hemolytic anemia 10.0
23 viral infectious disease 10.0
24 germ cells tumors 10.0
25 glioma 10.0
26 pdgfrb-associated chronic eosinophilic leukemia 10.0
27 parapharyngeal meningioma 9.9 CR1 CR2
28 t-cell/histiocyte rich large b cell lymphoma 9.9 CR1 CR2
29 lateral medullary syndrome 9.9 CR1 CR2
30 dendritic cell tumor 9.8 CR1 CR2
31 castleman disease 9.8 CR1 CR2
32 breast cancer 9.8
33 leukemia, acute monocytic 9.8
34 muir-torre syndrome 9.8
35 myelopathy, htlv-1-associated 9.8
36 pneumothorax, primary spontaneous 9.8
37 small cell cancer of the lung 9.8
38 ascites, chylous 9.8
39 lung cancer 9.8
40 myelofibrosis 9.8
41 aging 9.8
42 autoimmune lymphoproliferative syndrome 9.8
43 acute lymphoblastic leukemia, childhood 9.8
44 glomerulonephritis 9.8
45 mantle cell lymphoma 9.8
46 splenic marginal zone lymphoma 9.8
47 temporal lobe epilepsy 9.8
48 lymphoproliferative syndrome 9.8
49 thrombosis 9.8
50 chronic meningitis 9.8

Graphical network of the top 20 diseases related to Histiocytic Sarcoma:



Diseases related to Histiocytic Sarcoma

Symptoms & Phenotypes for Histiocytic Sarcoma

Drugs & Therapeutics for Histiocytic Sarcoma

Search Clinical Trials , NIH Clinical Center for Histiocytic Sarcoma

Genetic Tests for Histiocytic Sarcoma

Anatomical Context for Histiocytic Sarcoma

MalaCards organs/tissues related to Histiocytic Sarcoma:

41
Brain, Thyroid, B Cells, Spleen, Lung, Monocytes, Small Intestine

Publications for Histiocytic Sarcoma

Articles related to Histiocytic Sarcoma:

(show top 50) (show all 331)
# Title Authors Year
1
Favorable response to nivolumab in a young adult patient with metastatic histiocytic sarcoma. ( 30270506 )
2019
2
Primary mediastinal histiocytic sarcoma presenting as pleural effusion. ( 29756323 )
2018
3
Simultaneous Brain and Lung Histiocytic Sarcoma Revealed on 18F-FDG PET/CT. ( 29189378 )
2018
4
Morphological Distinction of Histiocytic Sarcoma from Other Tumor Types in Bernese Mountain Dogs and Flatcoated Retrievers. ( 29275293 )
2018
5
Comment on "MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma". ( 29491129 )
2018
6
Histiocytic sarcoma of the neck: A case report. ( 29977539 )
2018
7
Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome. ( 29850341 )
2018
8
Extranodal histiocytic sarcoma in a child with acute lymphoblastic leukemia: Cytomorphological features of a rare entity with brief review of literature. ( 29676378 )
2018
9
Primary cutaneous histiocytic sarcoma: A report of five cases with primary cutaneous involvement and review of the literature. ( 29414400 )
2018
10
A Case Report of Disseminated Canine Histiocytic Sarcoma in Trinidad and Tobago. ( 29351196 )
2018
11
Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? ( 29515976 )
2018
12
Histiocytic sarcoma in a child-successful management and long-term survival with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. ( 29630764 )
2018
13
Would you think of histiocytic sarcoma in this fine-needle aspiration? ( 29728735 )
2018
14
Histiocytic sarcoma with bladder involvement: Case report and literature review. ( 29290317 )
2018
15
Response to MEK inhibition with trametinib and tyrosine kinase inhibition with imatinib in multifocal histiocytic sarcoma. ( 29097496 )
2018
16
Primary central nervous system histiocytic sarcoma: A case report and review of literature. ( 29953002 )
2018
17
Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes. ( 29183888 )
2018
18
Molecular characteristics of multifocal brain histiocytic sarcoma. ( 29679510 )
2018
19
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies. ( 29490634 )
2018
20
Invasive nasal histiocytic sarcoma as a cause of temporal lobe epilepsy in a cat. ( 30450218 )
2018
21
Histiocytic Sarcoma Associated With Follicular Lymphoma: Evidence for Dramatic Response With Rituximab and Bendamustine Alone and a Review of the Literature. ( 30396823 )
2018
22
Trametinib in Histiocytic Sarcoma with an Activating MAP2K1 (MEK1) Mutation. ( 29768143 )
2018
23
Establishment and characterization of a cell line from a feline histiocytic sarcoma. ( 29914686 )
2018
24
Predictors of survival, treatment patterns, and outcomes in histiocytic sarcoma. ( 30032691 )
2018
25
Targeting MEK in a Translational Model of Histiocytic Sarcoma. ( 30135215 )
2018
26
Case of primary central nervous system histiocytic sarcoma with prominent proliferation of histiocytic cells between the trabeculae of reactive glial cells. ( 30155921 )
2018
27
Primary histiocytic sarcoma of the central nervous system: a case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review. ( 30185195 )
2018
28
Primary pulmonary histiocytic sarcoma in dogs: A retrospective analysis of 37 cases (2000-2015). ( 30246460 )
2018
29
Bone marrow infiltration of histiocytic sarcoma. ( 30310780 )
2018
30
A Rare Case of Primary Histiocytic Sarcoma of the Stomach. ( 30355826 )
2018
31
A case of recurrent histiocytic sarcoma with MAP2K1 pathogenic variant treated with the MEK inhibitor trametinib. ( 30361829 )
2018
32
Orbital Apex Syndrome in a Patient With Histiocytic Sarcoma. ( 30398544 )
2018
33
Histiocytic Sarcoma: Review, Discussion of Transformation From B-Cell Lymphoma, and Differential Diagnosis. ( 30407858 )
2018
34
Lomustine chemotherapy for the treatment of presumptive haemophagocytic histiocytic sarcoma in Flat-coated Retrievers. ( 30478839 )
2018
35
In this issue - December 2018: Pro bono wildlife work in Australian veterinary practices · Roaming owned dogs in Northern Australia · Snake stomach recovers after gastrectomy · Metronidazole-induced neurotoxicity in 26 dogs · Lomustine ineffective for haemophagocytic histiocytic sarcoma · Surgical swabs and dehorning wounds. ( 30478841 )
2018
36
An unexpected diagnosis of histiocytic sarcoma. ( 30502322 )
2018
37
Putative histiocytic sarcoma in redfin needlefish Strongylura notata (Beloniformes: Belonidae) in Florida, USA. ( 30530931 )
2018
38
Retroperitoneal Bulky Histiocytic Sarcoma Successfully Treated with Induction Chemotherapy Followed by Curative Surgery. ( 28924109 )
2017
39
Efficacy of dacarbazine as a rescue agent for histiocytic sarcoma in dogs. ( 28419676 )
2017
40
Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2. ( 28833247 )
2017
41
Canine histiocytic sarcoma presenting as a target lesion on brain magnetic resonance imaging and as a solitary pulmonary mass. ( 28419635 )
2017
42
Infection or Glioma? The False Dilemma of Primary Central Nervous System Histiocytic Sarcoma. ( 28711535 )
2017
43
Disseminated histiocytic sarcoma with hemophagocytosis in a rabbit. ( 28740033 )
2017
44
Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient. ( 28087030 )
2017
45
Histiocytic Sarcoma with p16-Overexpression Presenting as Uterine Cervical Mass. ( 29263052 )
2017
46
Invasive histiocytic sarcoma of the lumbar spine in a ferret (Mustela putorius furo). ( 28160308 )
2017
47
BRAF (V600E) expression in histiocytic sarcoma associated with splenic marginal zone lymphoma: a case report. ( 28376906 )
2017
48
Histiocytic sarcoma in 14 miniature schnauzers - a new breed predisposition? ( 28543363 )
2017
49
Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. ( 28621004 )
2017
50
Syndrome of inappropriate antidiuretic hormone secretion in a dog with a histiocytic sarcoma. ( 28698689 )
2017

Variations for Histiocytic Sarcoma

Expression for Histiocytic Sarcoma

Search GEO for disease gene expression data for Histiocytic Sarcoma.

Pathways for Histiocytic Sarcoma

GO Terms for Histiocytic Sarcoma

Biological processes related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.5 CR1 CR2 HAVCR2
2 complement activation, classical pathway GO:0006958 9.4 CR1 CR2
3 regulation of complement activation GO:0030449 9.37 CR1 CR2
4 viral entry into host cell GO:0046718 9.26 CR1 CR2
5 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.16 CDKN2A HAVCR2
6 innate immune response GO:0045087 9.13 CR1 CR2 HAVCR2
7 complement receptor mediated signaling pathway GO:0002430 8.62 CR1 CR2

Molecular functions related to Histiocytic Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 CR1 CR2

Sources for Histiocytic Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....