MCID: HST004
MIFTS: 33

Histiocytoid Hemangioma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Histiocytoid Hemangioma

MalaCards integrated aliases for Histiocytoid Hemangioma:

Name: Histiocytoid Hemangioma 12 15 71
Angiolymphoid Hyperplasia with Eosinophilia 12
Epithelioid Haemangioma 12
Epithelioid Hemangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:474
MeSH 44 D006391
NCIt 50 C4298
SNOMED-CT 67 253054009
UMLS 71 C0205788

Summaries for Histiocytoid Hemangioma

MalaCards based summary : Histiocytoid Hemangioma, also known as angiolymphoid hyperplasia with eosinophilia, is related to skin epithelioid hemangioma and hemangioma. An important gene associated with Histiocytoid Hemangioma is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and TGF-beta Signaling Pathway (WikiPathways). Affiliated tissues include bone, skin and endothelial, and related phenotype is neoplasm.

Wikipedia : 74 Angiolymphoid hyperplasia with eosinophilia (also known as: "Epithelioid hemangioma," "Histiocytoid... more...

Related Diseases for Histiocytoid Hemangioma

Diseases related to Histiocytoid Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 skin epithelioid hemangioma 32.5 PECAM1 CD34
2 hemangioma 31.1 PECAM1 FOSB CD34
3 kimura disease 30.8 THSD7A IL5
4 hemangioendothelioma 30.5 FOSB CD34 CAMTA1
5 angiosarcoma 30.3 PECAM1 CD34 CAMTA1
6 vascular cancer 30.3 WWTR1 TFE3 PECAM1 CD34 CAMTA1
7 central nervous system hemangioma 30.2 PECAM1 CD34
8 breast hemangioma 30.2 PECAM1 CD34
9 capillary hemangioma 29.9 PECAM1 CD34
10 epithelioid hemangioendothelioma 29.8 YAP1 WWTR1 TFE3 CAMTA1
11 malignant epithelioid hemangioendothelioma 29.4 YAP1 WWTR1 TFE3 FOSB CAMTA1
12 bone epithelioid hemangioma 11.5
13 breast epithelioid hemangioma 11.2
14 nephrotic syndrome 10.6
15 hypereosinophilic syndrome 10.5
16 temporal arteritis 10.4
17 membranous nephropathy 10.4
18 lymphoproliferative syndrome 10.4
19 arteriovenous malformation 10.4
20 vascular disease 10.4
21 exophthalmos 10.4
22 malignant hemangioma 10.3 WWTR1 CAMTA1
23 proliferative fasciitis 10.3 FOSB CAMTA1
24 sarcoidosis 1 10.3
25 lymphoma, hodgkin, classic 10.3
26 mycosis fungoides 10.3
27 dermatitis, atopic 10.3
28 human herpesvirus 8 10.3
29 proteinuria, chronic benign 10.3
30 peripheral t-cell lymphoma 10.3
31 ptosis 10.3
32 igg4-related disease 10.3
33 purpura 10.3
34 skin disease 10.3
35 prurigo nodularis 10.3
36 aneurysm 10.3
37 angiomatosis 10.3
38 aortic malignant tumor 10.2 PECAM1 CD34
39 prostate angiosarcoma 10.2 PECAM1 CD34
40 central nervous system angiosarcoma 10.2 PECAM1 CD34
41 intravascular angioleiomyoma 10.2 PECAM1 CD34
42 heart fibrosarcoma 10.2 PECAM1 CD34
43 ovarian angiosarcoma 10.2 PECAM1 CD34
44 gallbladder leiomyosarcoma 10.2 PECAM1 CD34
45 thyroid sarcoma 10.2 PECAM1 CD34
46 pediatric angiosarcoma 10.2 PECAM1 CD34
47 angiomyoma 10.2 PECAM1 CD34
48 retroperitoneal hemangiopericytoma 10.2 PECAM1 CD34
49 glomangiosarcoma 10.2 PECAM1 CD34
50 hemangioma of spleen 10.2 PECAM1 CD34

Graphical network of the top 20 diseases related to Histiocytoid Hemangioma:



Diseases related to Histiocytoid Hemangioma

Symptoms & Phenotypes for Histiocytoid Hemangioma

MGI Mouse Phenotypes related to Histiocytoid Hemangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 CAMTA1 CD34 FOS IL5 YAP1

Drugs & Therapeutics for Histiocytoid Hemangioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epithelioid Hemangioma of Bone And Soft Tissue: a Benign Tumor With Metastatic Potential Completed NCT03169595

Search NIH Clinical Center for Histiocytoid Hemangioma

Genetic Tests for Histiocytoid Hemangioma

Anatomical Context for Histiocytoid Hemangioma

MalaCards organs/tissues related to Histiocytoid Hemangioma:

40
Bone, Skin, Endothelial, Testis, Spinal Cord, Colon, Tongue

Publications for Histiocytoid Hemangioma

Articles related to Histiocytoid Hemangioma:

(show top 50) (show all 243)
# Title Authors PMID Year
1
Epithelioid Hemangioma of Vertebra Mimicking Metastasis on FDG PET/CT in a Patient With Renal Cell Cancer. 61
33315666 2021
2
Primary Epithelioid Hemangioma of the Central Nervous System: A Case Report and Review of the Literature. 61
33411905 2021
3
Transarticular epithelioid hemangioma of the ankle-a case of a rare vascular neoplasm. 61
33420574 2021
4
Concurrent epithelioid hemangioma and diffuse cavernous hemangioma in the rectum clinically mimicking a malignant tumor: a case report. 61
33496804 2021
5
Previously unreported permanent tattoo-associated angiolymphoid hyperplasia with eosinophilia/epithelioid hemangioma. 61
33503288 2021
6
Epithelioid hemangioma of bone harboring FOS and FOSB gene rearrangements: A clinicopathologic and molecular study. 61
33034932 2021
7
The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology? 61
32796172 2021
8
Novel GATA6-FOXO1 fusions in a subset of epithelioid hemangioma. 61
33318580 2020
9
Epithelioid hemangioma of breast mimicking malignancy: One trap during rapid frozen pathologic diagnosis. 61
32562298 2020
10
Primary Vascular Tumors of Bone: A Monoinstitutional Morphologic and Molecular Analysis of 427 Cases With Emphasis on Epithelioid Variants. 61
32271190 2020
11
F18-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of vertebral vascular tumors. 61
32353715 2020
12
Cutaneous intravascular epithelioid hemangioma. A clinicopathological and molecular study of 21 cases. 61
32094426 2020
13
Multifocal Epithelioid Hemangioma of the Penis in a 4-Year-Old Child: A Case Report. 61
31693501 2020
14
What is new in endothelial neoplasia? 61
31463731 2020
15
Multifocal epithelioid hemangioma of the metacarpal bones: A case report. 61
31641394 2019
16
Bisphosphonates as a therapeutic choice for multifocal epithelioid hemangioma of bone: A case report. 61
31770261 2019
17
Epithelioid hemangioma of bone: A unique case with multifocal metachronous bone lesions. 61
31708630 2019
18
Epithelioid Hemangioma of the Thoracic Spine: A Case Report and Review of the Literature. 61
29065791 2019
19
Treatment of lumbar vertebra epithelioid hemangioma with radiation therapy: a case report. 61
31615579 2019
20
Orbital Cellular Epithelioid Hemangioma. 61
31768366 2019
21
Recurrent Epithelioid Hemangioma of the Bony Pelvis Responding to Propranolol. 61
31607887 2019
22
Primary vascular bone tumors in the spine: a challenge for pathologists and spine oncology surgeons. 61
30900092 2019
23
Epithelioid hemangioendothelioma of the bone: A case report with findings of bone scintigraphy. 61
31083212 2019
24
Epithelioid Vascular Tumors: A Review. 61
30762622 2019
25
The Molecular Diagnostics of Vascular Neoplasms. 61
30709447 2019
26
Hepatic YAP1-TFE3 Rearranged Epithelioid Hemangioendothelioma. 61
31341686 2019
27
Multiple Eruptive Epithelioid Hemangiomas: A Subset of Cutaneous Cellular Epithelioid Hemangioma With Expression of FOS-B. 61
29266025 2019
28
Classic Hodgkin lymphoma with initial extranodal osseous presentation: a case report and literature review. 61
31463427 2019
29
Characterization of long-term outcomes for pediatric patients with epithelioid hemangioma. 61
30207085 2019
30
Epithelioid hemangioma of the orbit treated with oral propranolol in adult. 61
30503005 2018
31
Epithelioid Hemangioma of the Face. 61
30277937 2018
32
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update. 61
30134255 2018
33
Angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma) of the external auditory canal, an unusual presentation in an adult female: a case report. 61
29992002 2018
34
FOSB immunoreactivity in endothelia of epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia). 61
29527734 2018
35
Epithelioid hemangioma of the scapula treated with chemoembolization and microwave ablation: Α case report. 61
28159479 2018
36
Primary Epithelioid Angiosarcoma of Finger Masquerading as Epithelioid Hemangioma: Report of a Case and Analysis of Mutational Pattern in Epithelioid Hemangiomas and Angiosarcomas by Next-generation Sequencing. 61
29206716 2018
37
Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis. 61
29150442 2017
38
Epithelioid hemangioma of bone: radiologic and magnetic resonance imaging characteristics with histopathological correlation. 61
28721475 2017
39
Epithelioid hemangioma of penis mimicking malignancy: A rare case. 61
29118548 2017
40
The Disappearing Phalanx: A Case Report of a Vascular Tumor of the Toe. 61
28633787 2017
41
L1 Epithelioid Hemangioma. 61
28459193 2017
42
Cutaneous epithelioid angiomatous nodule versus epithelioid hemangioma: A dilemma. 61
27779150 2017
43
Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically. 61
27979335 2017
44
Epithelioid hemangioma of bone: a report of two special cases and a literature review. 61
27660230 2016
45
Linear Multiple Epithelioid Hemangioma Associated With a Quiescent Vascular Malformation. 61
27491872 2016
46
Ulnar arterial epithelioid hemangioma: A unique demonstration using time-resolved MR angiography. 61
27525371 2016
47
Epithelioid hemangioma in the oral mucosa – A case report. 61
29653041 2016
48
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions. 61
27318413 2016
49
Epithelioid Hemangioma (Angiolymphoid Hyperplasia With Eosinophilia) of the Heart With Peripheral Eosinophilia and Nephrotic Syndrome. 61
26338719 2016
50
Epithelioid hemangioma of the spine: an uncommon cause of spinal cord compression. 61
25672266 2015

Variations for Histiocytoid Hemangioma

Expression for Histiocytoid Hemangioma

Search GEO for disease gene expression data for Histiocytoid Hemangioma.

Pathways for Histiocytoid Hemangioma

Pathways related to Histiocytoid Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 IL5 FOSB FOS
2 11.46 YAP1 FOSB FOS
3 11.1 YAP1 WWTR1 PPP1R10
4 10.78 YAP1 WWTR1
5 10.69 TFE3 IL5 FOS
6 10.58 YAP1 WWTR1

GO Terms for Histiocytoid Hemangioma

Biological processes related to Histiocytoid Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein localization to nucleus GO:1900182 9.48 YAP1 WWTR1
2 regulation of canonical Wnt signaling pathway GO:0060828 9.46 YAP1 WWTR1
3 cellular response to hormone stimulus GO:0032870 9.43 FOSB FOS
4 hippo signaling GO:0035329 9.4 YAP1 WWTR1
5 response to corticosterone GO:0051412 9.37 FOSB FOS
6 response to progesterone GO:0032570 9.33 YAP1 FOSB FOS
7 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.32 YAP1 WWTR1
8 heart process GO:0003015 9.26 YAP1 WWTR1
9 glomerular endothelium development GO:0072011 8.96 PECAM1 CD34
10 tissue homeostasis GO:0001894 8.8 YAP1 WWTR1 CD34

Molecular functions related to Histiocytoid Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 9.13 FOSB FOS CAMTA1
2 transcription factor binding GO:0008134 8.92 YAP1 FOSB FOS CD34

Sources for Histiocytoid Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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