MCID: HST004
MIFTS: 32

Histiocytoid Hemangioma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Histiocytoid Hemangioma

MalaCards integrated aliases for Histiocytoid Hemangioma:

Name: Histiocytoid Hemangioma 12 15 71
Angiolymphoid Hyperplasia with Eosinophilia 12
Epithelioid Haemangioma 12
Epithelioid Hemangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:474
MeSH 43 D006391
NCIt 49 C4298
SNOMED-CT 67 33929001
UMLS 71 C0205788

Summaries for Histiocytoid Hemangioma

MalaCards based summary : Histiocytoid Hemangioma, also known as angiolymphoid hyperplasia with eosinophilia, is related to skin epithelioid hemangioma and hemangioma. An important gene associated with Histiocytoid Hemangioma is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are TGF-beta Signaling Pathway (WikiPathways) and PI3K / Akt Signaling. Affiliated tissues include bone, heart and skin.

Wikipedia : 74 Angiolymphoid hyperplasia with eosinophilia (also known as: "Epithelioid hemangioma," "Histiocytoid... more...

Related Diseases for Histiocytoid Hemangioma

Diseases related to Histiocytoid Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 skin epithelioid hemangioma 33.0 PECAM1 CD34
2 hemangioma 31.4 PECAM1 FOSB CD34
3 hemangioendothelioma 30.9 FOSB CD34 CAMTA1
4 angiosarcoma 30.7 PECAM1 CD34 CAMTA1
5 bacillary angiomatosis 30.5 PECAM1 CD34
6 breast hemangioma 30.3 PECAM1 CD34
7 vascular cancer 30.2 WWTR1 TFE3 PECAM1 CD34 CAMTA1
8 epithelioid hemangioendothelioma 30.1 YAP1 WWTR1 TFE3 CAMTA1
9 capillary hemangioma 30.1 PECAM1 CD34
10 malignant epithelioid hemangioendothelioma 29.4 YAP1 WWTR1 TFE3 FOSB CAMTA1
11 bone epithelioid hemangioma 12.6
12 breast epithelioid hemangioma 11.5
13 kimura disease 10.8
14 nephrotic syndrome 10.6
15 hypereosinophilic syndrome 10.6
16 malignant hemangioma 10.4 WWTR1 CAMTA1
17 proliferative fasciitis 10.4 FOSB CAMTA1
18 temporal arteritis 10.4
19 membranous nephropathy 10.4
20 lymphoproliferative syndrome 10.4
21 arteriovenous malformation 10.4
22 vascular disease 10.4
23 exophthalmos 10.4
24 aortic malignant tumor 10.4 PECAM1 CD34
25 prostate angiosarcoma 10.3 PECAM1 CD34
26 central nervous system angiosarcoma 10.3 PECAM1 CD34
27 intravascular angioleiomyoma 10.3 PECAM1 CD34
28 heart fibrosarcoma 10.3 PECAM1 CD34
29 central nervous system hemangioma 10.3 PECAM1 CD34
30 ovarian angiosarcoma 10.3 PECAM1 CD34
31 pediatric angiosarcoma 10.3 PECAM1 CD34
32 angiomyoma 10.3 PECAM1 CD34
33 gallbladder leiomyosarcoma 10.3 PECAM1 CD34
34 glomangiosarcoma 10.3 PECAM1 CD34
35 thyroid sarcoma 10.3 PECAM1 CD34
36 liposarcoma of bone 10.3 PECAM1 CD34
37 hemangioma of spleen 10.3 PECAM1 CD34
38 nephrogenic adenofibroma 10.3 TFE3 CD34
39 kaposiform hemangioendothelioma 10.3 PECAM1 CD34
40 liver leiomyoma 10.3 PECAM1 CD34
41 retroperitoneal hemangiopericytoma 10.3 PECAM1 CD34
42 benign perivascular tumor 10.3 PECAM1 CD34
43 intramuscular hemangioma 10.3 PECAM1 CD34
44 colonic lymphangioma 10.3 PECAM1 CD34
45 sarcomatoid squamous cell skin carcinoma 10.3 PECAM1 CD34
46 hobnail hemangioma 10.3 PECAM1 CD34
47 breast angiosarcoma 10.3 PECAM1 CD34
48 skin sarcoma 10.3 PECAM1 CD34
49 erythema elevatum diutinum 10.3 PECAM1 CD34
50 heart sarcoma 10.3 PECAM1 CD34

Graphical network of the top 20 diseases related to Histiocytoid Hemangioma:



Diseases related to Histiocytoid Hemangioma

Symptoms & Phenotypes for Histiocytoid Hemangioma

Drugs & Therapeutics for Histiocytoid Hemangioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epithelioid Hemangioma of Bone And Soft Tissue: a Benign Tumor With Metastatic Potential Completed NCT03169595

Search NIH Clinical Center for Histiocytoid Hemangioma

Genetic Tests for Histiocytoid Hemangioma

Anatomical Context for Histiocytoid Hemangioma

MalaCards organs/tissues related to Histiocytoid Hemangioma:

40
Bone, Heart, Skin, Breast, Endothelial, Testis, Spinal Cord

Publications for Histiocytoid Hemangioma

Articles related to Histiocytoid Hemangioma:

(show top 50) (show all 236)
# Title Authors PMID Year
1
Epithelioid hemangioma of breast mimicking malignancy: One trap during rapid frozen pathologic diagnosis. 61
32562298 2020
2
Multifocal Epithelioid Hemangioma of the Penis in a 4-Year-Old Child: A Case Report. 61
31693501 2020
3
F18-fluorodeoxyglucose positron emission tomography/computed tomography in the evaluation of vertebral vascular tumors. 61
32353715 2020
4
Primary Vascular Tumors of Bone: A Monoinstitutional Morphologic and Molecular Analysis of 427 Cases With Emphasis on Epithelioid Variants. 61
32271190 2020
5
Cutaneous intravascular epithelioid hemangioma. A clinicopathological and molecular study of 21 cases. 61
32094426 2020
6
What is new in endothelial neoplasia? 61
31463731 2020
7
Multifocal epithelioid hemangioma of the metacarpal bones: A case report. 61
31641394 2019
8
Epithelioid hemangioma of bone: A unique case with multifocal metachronous bone lesions. 61
31708630 2019
9
Bisphosphonates as a therapeutic choice for multifocal epithelioid hemangioma of bone: A case report. 61
31770261 2019
10
Epithelioid Hemangioma of the Thoracic Spine: A Case Report and Review of the Literature. 61
29065791 2019
11
Treatment of lumbar vertebra epithelioid hemangioma with radiation therapy: a case report. 61
31615579 2019
12
Orbital Cellular Epithelioid Hemangioma. 61
31768366 2019
13
Recurrent Epithelioid Hemangioma of the Bony Pelvis Responding to Propranolol. 61
31607887 2019
14
Primary vascular bone tumors in the spine: a challenge for pathologists and spine oncology surgeons. 61
30900092 2019
15
Epithelioid hemangioendothelioma of the bone: A case report with findings of bone scintigraphy. 61
31083212 2019
16
Epithelioid Vascular Tumors: A Review. 61
30762622 2019
17
The Molecular Diagnostics of Vascular Neoplasms. 61
30709447 2019
18
Multiple Eruptive Epithelioid Hemangiomas: A Subset of Cutaneous Cellular Epithelioid Hemangioma With Expression of FOS-B. 61
29266025 2019
19
Hepatic YAP1-TFE3 Rearranged Epithelioid Hemangioendothelioma. 61
31341686 2019
20
Classic Hodgkin lymphoma with initial extranodal osseous presentation: a case report and literature review. 61
31463427 2019
21
Characterization of long-term outcomes for pediatric patients with epithelioid hemangioma. 61
30207085 2019
22
Epithelioid hemangioma of the orbit treated with oral propranolol in adult. 61
30503005 2018
23
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update. 61
30134255 2018
24
Epithelioid Hemangioma of the Face. 61
30277937 2018
25
Angiolymphoid hyperplasia with eosinophilia (epithelioid hemangioma) of the external auditory canal, an unusual presentation in an adult female: a case report. 61
29992002 2018
26
FOSB immunoreactivity in endothelia of epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia). 61
29527734 2018
27
Epithelioid hemangioma of the scapula treated with chemoembolization and microwave ablation: Α case report. 61
28159479 2018
28
Primary Epithelioid Angiosarcoma of Finger Masquerading as Epithelioid Hemangioma: Report of a Case and Analysis of Mutational Pattern in Epithelioid Hemangiomas and Angiosarcomas by Next-generation Sequencing. 61
29206716 2018
29
Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis. 61
29150442 2017
30
Epithelioid hemangioma of bone: radiologic and magnetic resonance imaging characteristics with histopathological correlation. 61
28721475 2017
31
Epithelioid hemangioma of penis mimicking malignancy: A rare case. 61
29118548 2017
32
The Disappearing Phalanx: A Case Report of a Vascular Tumor of the Toe. 61
28633787 2017
33
L1 Epithelioid Hemangioma. 61
28459193 2017
34
Cutaneous epithelioid angiomatous nodule versus epithelioid hemangioma: A dilemma. 61
27779150 2017
35
Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically. 61
27979335 2017
36
Linear Multiple Epithelioid Hemangioma Associated With a Quiescent Vascular Malformation. 61
27491872 2016
37
Epithelioid hemangioma of bone: a report of two special cases and a literature review. 61
27660230 2016
38
Ulnar arterial epithelioid hemangioma: A unique demonstration using time-resolved MR angiography. 61
27525371 2016
39
Epithelioid hemangioma in the oral mucosa – A case report. 61
29653041 2016
40
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions. 61
27318413 2016
41
Epithelioid Hemangioma (Angiolymphoid Hyperplasia With Eosinophilia) of the Heart With Peripheral Eosinophilia and Nephrotic Syndrome. 61
26338719 2016
42
Epithelioid hemangioma of the spine: an uncommon cause of spinal cord compression. 61
25672266 2015
43
Epithelioid hemangiomas arising in the coronary artery and right ventricle: A case report. 61
26593987 2015
44
Frequent FOS Gene Rearrangements in Epithelioid Hemangioma: A Molecular Study of 58 Cases With Morphologic Reappraisal. 61
26135557 2015
45
Diagnostically Challenging Epithelioid Vascular Tumors. 61
26297060 2015
46
Fusion events lead to truncation of FOS in epithelioid hemangioma of bone. 61
26173738 2015
47
Commentary: Epithelioid hemangioma of spine. 61
26238903 2015
48
Epithelioid hemangioma of the thoracic spine. 61
26238902 2015
49
Angiolymphoid hyperplasia with eosinophilia. 61
25927152 2015
50
Multifocal epithelioid hemangioma of the penis: a diagnostic and therapeutic challenge. 61
26042800 2015

Variations for Histiocytoid Hemangioma

Expression for Histiocytoid Hemangioma

Search GEO for disease gene expression data for Histiocytoid Hemangioma.

Pathways for Histiocytoid Hemangioma

Pathways related to Histiocytoid Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 YAP1 FOSB FOS
2 11.1 YAP1 WWTR1 PPP1R10
3 10.78 YAP1 WWTR1
4 10.69 TFE3 IL5 FOS
5 10.58 YAP1 WWTR1

GO Terms for Histiocytoid Hemangioma

Biological processes related to Histiocytoid Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 YAP1 WWTR1 TFE3 FOSB FOS CAMTA1
2 regulation of canonical Wnt signaling pathway GO:0060828 9.46 YAP1 WWTR1
3 hippo signaling GO:0035329 9.43 YAP1 WWTR1
4 response to corticosterone GO:0051412 9.4 FOSB FOS
5 response to progesterone GO:0032570 9.33 YAP1 FOSB FOS
6 heart process GO:0003015 9.32 YAP1 WWTR1
7 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.26 YAP1 WWTR1
8 glomerular endothelium development GO:0072011 8.96 PECAM1 CD34
9 tissue homeostasis GO:0001894 8.8 YAP1 WWTR1 CD34

Molecular functions related to Histiocytoid Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.35 VGLL3 TFE3 FOSB FOS CAMTA1
2 transcription factor binding GO:0008134 8.92 YAP1 FOSB FOS CD34

Sources for Histiocytoid Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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