AFH
MCID: HST022
MIFTS: 29

Histiocytoma, Angiomatoid Fibrous (AFH)

Categories: Cancer diseases, Genetic diseases

Aliases & Classifications for Histiocytoma, Angiomatoid Fibrous

MalaCards integrated aliases for Histiocytoma, Angiomatoid Fibrous:

Name: Histiocytoma, Angiomatoid Fibrous 58 74
Angiomatoid Fibrous Histiocytoma 76 30 41
Histiocytoma, Angiomatoid Fibrous, Somatic 58 13
Afh 76

Characteristics:

HPO:

33
histiocytoma, angiomatoid fibrous:
Inheritance somatic mutation


Classifications:



External Ids:

OMIM 58 612160
MeSH 45 D051677
MedGen 43 C1266127
SNOMED-CT via HPO 70 124975008 128741006 302843004
UMLS 74 C1266127

Summaries for Histiocytoma, Angiomatoid Fibrous

UniProtKB/Swiss-Prot : 76 Angiomatoid fibrous histiocytoma: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.

MalaCards based summary : Histiocytoma, Angiomatoid Fibrous, also known as angiomatoid fibrous histiocytoma, is related to histiocytoma and fibrous histiocytoma. An important gene associated with Histiocytoma, Angiomatoid Fibrous is CREB1 (CAMP Responsive Element Binding Protein 1). The drugs Ifosfamide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone and lung, and related phenotype is histiocytoma.

Wikipedia : 77 Angiomatoid fibrous histiocytoma, abbreviated AFH, is a rarely metastasizing tumour that affects... more...

Description from OMIM: 612160

Related Diseases for Histiocytoma, Angiomatoid Fibrous

Diseases related to Histiocytoma, Angiomatoid Fibrous via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 10.5
2 fibrous histiocytoma 10.4
3 sarcoma 10.3
4 storage pool platelet disease 10.2
5 sarcoma, synovial 10.2
6 membranous nephropathy 10.2
7 polyarteritis nodosa, childhood-onset 10.2
8 granuloma annulare 10.2
9 angiosarcoma 10.2
10 melanoma 10.2
11 testicular cancer 10.2
12 polyarteritis nodosa 10.2

Graphical network of the top 20 diseases related to Histiocytoma, Angiomatoid Fibrous:



Diseases related to Histiocytoma, Angiomatoid Fibrous

Symptoms & Phenotypes for Histiocytoma, Angiomatoid Fibrous

Human phenotypes related to Histiocytoma, Angiomatoid Fibrous:

33
# Description HPO Frequency HPO Source Accession
1 histiocytoma 33 HP:0012315

Clinical features from OMIM:

612160

Drugs & Therapeutics for Histiocytoma, Angiomatoid Fibrous

Drugs for Histiocytoma, Angiomatoid Fibrous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
3
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
4
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6
Isophosphamide mustard Phase 2, Phase 3 0
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antineoplastic Agents, Alkylating Phase 2, Phase 3
9 Topoisomerase Inhibitors Phase 2, Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 Angiomatoid Fibrous Histiocytoma: a Single Institution Case-series Not yet recruiting NCT03759327

Search NIH Clinical Center for Histiocytoma, Angiomatoid Fibrous

Genetic Tests for Histiocytoma, Angiomatoid Fibrous

Genetic tests related to Histiocytoma, Angiomatoid Fibrous:

# Genetic test Affiliating Genes
1 Angiomatoid Fibrous Histiocytoma 30 CREB1

Anatomical Context for Histiocytoma, Angiomatoid Fibrous

MalaCards organs/tissues related to Histiocytoma, Angiomatoid Fibrous:

42
Lymph Node, Bone, Lung, Skin

Publications for Histiocytoma, Angiomatoid Fibrous

Articles related to Histiocytoma, Angiomatoid Fibrous:

(show top 50) (show all 90)
# Title Authors Year
1
Hybrid bronchoscopic and surgical resection of endotracheal angiomatoid fibrous histiocytoma. ( 30819218 )
2019
2
Primary Adrenal Angiomatoid Fibrous Histiocytoma With Novel EWSR1-ATF1 Gene Fusion Exon-Exon Breakpoint. ( 30823861 )
2019
3
Intracranial angiomatoid fibrous histiocytoma with EWSR1-CREB family fusions: a report of two pediatric cases. ( 30831299 )
2019
4
Retroperitoneal Angiomatoid Fibrous Histiocytoma Presenting as a Recurrent Spontaneous Retroperitoneal Hemorrhage in a 9-Year-Old Boy. ( 29432314 )
2018
5
Primary intracranial angiomatoid fibrous histiocytoma: a case report and literature review. ( 29540076 )
2018
6
ALK Expression in Angiomatoid Fibrous Histiocytoma: A Potential Diagnostic Pitfall. ( 29877921 )
2018
7
Therapeutic response of metastatic angiomatoid fibrous histiocytoma carrying EWSR1-CREB1 fusion to the interleukin-6 receptor antibody tocilizumab. ( 29932283 )
2018
8
Angiomatoid Fibrous Histiocytoma With Paraneoplastic Platelet Storage Pool Deficiency. ( 29472492 )
2018
9
ESWR1-CREM Fusion in an Intracranial Myxoid Angiomatoid Fibrous Histiocytoma-Like Tumor: A Case Report and Literature Review. ( 29788195 )
2018
10
A Case of Angiomatoid Fibrous Histiocytoma Presenting as Subcutaneous Nodule in a 4-Year-Old Girl. ( 29606824 )
2018
11
Treatment of angiomatoid fibrous histiocytoma after unplanned excision: a case report. ( 30170609 )
2018
12
TLE-1-Positive Angiomatoid Fibrous Histiocytoma Mimicking Synovial Sarcoma. ( 28248724 )
2017
13
Angiomatoid fibrous histiocytoma of the scalp mimicking cutaneous angiosarcoma in incisional biopsy containing CD31-positive histiocytes: A potential histopathological pitfall. ( 28370384 )
2017
14
CORR Insights(Ar): Pathologically Benign Lymph Nodes Can Mimic Malignancy on Imaging in Patients With Angiomatoid Fibrous Histiocytoma. ( 28656494 )
2017
15
Pathologically Benign Lymph Nodes Can Mimic Malignancy on Imaging in Patients With Angiomatoid Fibrous Histiocytoma. ( 28536856 )
2017
16
Intracranial myxoid mesenchymal tumors with EWSR1-CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity? ( 28281318 )
2017
17
Angiomatoid fibrous histiocytoma: a series of seven cases including genetically confirmed aggressive cases and a literature review. ( 28114920 )
2017
18
'Pure' spindle cell variant of angiomatoid fibrous histiocytoma, lacking classic histologic features. ( 27637157 )
2016
19
Angiomatoid fibrous histiocytoma: Clinicopathological spectrum of five cases, including EWSR1-CREB1 positive result in a single case. ( 27166030 )
2016
20
Intracranial Angiomatoid Fibrous Histiocytoma: Case Report and Literature Review. ( 27667574 )
2016
21
Angiomatoid fibrous histiocytoma: A case of local recurrence and metastases to loco-regional lymph nodes that responded to chemotherapy. ( 28012233 )
2016
22
Angiomatoid fibrous histiocytoma: novel MR imaging findings. ( 26919861 )
2016
23
Primary Angiomatoid Fibrous Histiocytoma of the Lung with Mediastinal Lymph Node Metastasis. ( 27544801 )
2016
24
Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation. ( 26162466 )
2015
25
Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production. ( 26165403 )
2015
26
Clinicopathological features of angiomatoid fibrous histiocytoma: a series of 21 cases with variant morphology. ( 25755773 )
2015
27
Primary intracranial angiomatoid fibrous histiocytoma presenting with anaemia and migraine-like headaches and aura as early clinical features. ( 25900984 )
2015
28
Characterization of metastatic angiomatoid fibrous histiocytoma. ( 25757019 )
2015
29
Angiomatoid fibrous histiocytoma: comparison of fluorescence in situ hybridization and reverse transcription polymerase chain reaction as adjunct diagnostic modalities. ( 25804255 )
2015
30
Angiomatoid fibrous histiocytoma - case series with emphasis on a late fibrotic variant. ( 25918088 )
2015
31
Angiomatoid fibrous histiocytoma: the current status of pathology and genetics. ( 25927151 )
2015
32
Angiomatoid fibrous histiocytoma: case report and review of the literature. ( 26613231 )
2015
33
Angiomatoid fibrous histiocytoma: clinicopathological and molecular characterisation with emphasis on variant histomorphology. ( 24043718 )
2014
34
Recurrent angiomatoid fibrous histiocytoma: a case report and review of the literature. ( 25249813 )
2014
35
Recurrent painful perianal subcutaneous angiomatoid fibrous histiocytoma: a case report and review of the literature. ( 25526437 )
2014
36
Angiomatoid Fibrous Histiocytoma With Prominent Myxoid Stroma: A Case Report and Review of the Literature. ( 25406850 )
2014
37
A case report: angiomatoid fibrous histiocytoma in a 6-year-old male and review of the literature. ( 24521435 )
2014
38
Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum. ( 24614712 )
2014
39
Angiomatoid fibrous histiocytoma of the pulmonary artery: a multidisciplinary discussion. ( 24702653 )
2014
40
Ultrasound B-mode and elastographic findings of angiomatoid fibrous histiocytoma. ( 24758358 )
2014
41
Membranous nephropathy associated with angiomatoid fibrous histiocytoma in a pediatric patient. ( 24880818 )
2014
42
Solid Variant of Angiomatoid Fibrous Histiocytoma Masked by Interstitial Granuloma Annulare in a 13-year-old Child: No Evidence for Translocation Breakpoints. ( 24002209 )
2013
43
At the Intersection of Primary Pulmonary Myxoid Sarcoma and Pulmonary Angiomatoid Fibrous Histiocytoma: Observations from Three New Cases. ( 24372335 )
2013
44
Angiomatoid fibrous histiocytoma as a second tumor in a young adult with testicular cancer. ( 24155684 )
2013
45
Retroperitoneal angiomatoid fibrous histiocytoma: A case report and review of the literature. ( 23833650 )
2013
46
Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis. ( 23199525 )
2013
47
Subcutaneous angiomatoid fibrous histiocytoma mimicking metastatic melanoma. ( 23320232 )
2012
48
Angiomatoid fibrous histiocytoma: pleomorphic variant associated with multiplication of EWSR1-CREB1 fusion gene. ( 22038502 )
2012
49
Angiomatoid fibrous histiocytoma a series of five cytologic cases with literature review and emphasis on diagnostic pitfalls. ( 22045622 )
2012
50
Angiomatoid fibrous histiocytoma on the hard palate: case report. ( 21965132 )
2012

Variations for Histiocytoma, Angiomatoid Fibrous

Expression for Histiocytoma, Angiomatoid Fibrous

Search GEO for disease gene expression data for Histiocytoma, Angiomatoid Fibrous.

Pathways for Histiocytoma, Angiomatoid Fibrous

GO Terms for Histiocytoma, Angiomatoid Fibrous

Sources for Histiocytoma, Angiomatoid Fibrous

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