MCID: HST011
MIFTS: 56

Histoplasmosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Histoplasmosis

MalaCards integrated aliases for Histoplasmosis:

Name: Histoplasmosis 12 76 59 43 3 44 15 73
Infection by Histoplasma Capsulatum 73
Reticuloendotheliosis, X-Linked 44
Darling Disease 59

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1731
ICD10 33 B39 B39.9 B39.4
ICD9CM 35 115 115.9
SNOMED-CT 68 12962009
Orphanet 59 ORPHA390
MESH via Orphanet 45 D006660
UMLS via Orphanet 74 C0019655 C0153261
ICD10 via Orphanet 34 B39.0 B39.1 B39.2 more

Summaries for Histoplasmosis

MedlinePlus : 43 Histoplasmosis is a disease caused by a fungus (or mold) called Histoplasma. The fungus is common in the eastern and central United States. It grows in soil and material contaminated with bat or bird droppings. You get infected by breathing the fungal spores. You cannot get the infection from someone else. Histoplasmosis is often mild, with no symptoms. If you do get sick, it usually affects your lungs. Symptoms include feeling ill, fever, chest pains, and a dry cough. In severe cases, histoplasmosis spreads to other organs. This is called disseminated disease. It is more common in infants, young children, seniors, and people with immune system problems. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. Mild cases usually get better without treatment. Treatment of severe or chronic cases is with antifungal drugs. Centers for Disease Control and Prevention

MalaCards based summary : Histoplasmosis, also known as infection by histoplasma capsulatum, is related to arthritis and rheumatoid arthritis, and has symptoms including fever and pruritus. An important gene associated with Histoplasmosis is ATP6V1A (ATPase H+ Transporting V1 Subunit A), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Voriconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A primary systemic mycosis that results in systemic fungal infection, has material basis in Histoplasma capsulatum var capsulatum or has material basis in Histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC : 3 Histoplasmosis is an infection caused by a fungus called Histoplasma. The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings. In the United States, Histoplasma mainly lives in the central and eastern states, especially areas around the Ohio and Mississippi River valleys. The fungus also lives in parts of Central and South America, Africa, Asia, and Australia.

Wikipedia : 76 Histoplasmosis (also known as "Cave disease", "Darling''s disease", "Ohio valley disease",... more...

Related Diseases for Histoplasmosis

Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)
# Related Disease Score Top Affiliating Genes
1 arthritis 30.2 HLA-DRB1 IFNG MICA
2 rheumatoid arthritis 29.9 HLA-B HLA-DQA1 HLA-DRB1 IFNG
3 panuveitis 29.8 HLA-A HLA-B HLA-DRB1
4 aphthous stomatitis 29.6 HLA-A HLA-B
5 inflammatory bowel disease 29.5 HLA-B HLA-DQA1 HLA-DRB1 IFNG
6 psoriatic arthritis 29.5 HLA-B HLA-DRB1 MICA
7 aplastic anemia 29.4 HLA-A HLA-B HLA-DRB1 IFNG
8 connective tissue disease 29.1 HLA-DQA1 HLA-DRB1 IFNG MICA
9 american histoplasmosis 12.5
10 african histoplasmosis 12.5
11 reticuloendotheliosis, x-linked 12.4
12 histoplasmosis pericarditis 12.2
13 histoplasmosis retinitis 12.2
14 histoplasmosis meningitis 12.1
15 blastomycosis 11.4
16 fibrosing mediastinitis 11.4
17 reticuloendotheliosis 11.2
18 rickets 11.0
19 chronic rhinitis 11.0
20 acquired immunodeficiency syndrome 10.4
21 coccidioidomycosis 10.3
22 hemophagocytic lymphohistiocytosis 10.3
23 phenytoin or carbamazepine toxicity 10.2 HLA-A HLA-B
24 atrial tachyarrhythmia with short pr interval 10.2 HLA-A HLA-B
25 baylisascariasis 10.2 ATP6V1A IFNG
26 paracoccidioidomycosis 10.2
27 hemorrhagic fever 10.2 HLA-DRB1 IFNG
28 microscopic polyangiitis 10.2 HLA-B HLA-DRB1
29 idiopathic inflammatory myopathy 10.2 HLA-B HLA-DRB1
30 anterior uveitis 10.2 HLA-A HLA-B
31 intermediate uveitis 10.2 HLA-B IFNG
32 chronic pyelonephritis 10.2 HLA-A HLA-B
33 human herpesvirus 8 10.2 HLA-A HLA-B
34 berylliosis 10.2 HLA-DRB1 IFNG
35 chronic beryllium disease 10.2 HLA-DRB1 IFNG
36 progressive bulbar palsy 10.2 HLA-A TF
37 human immunodeficiency virus infectious disease 10.2
38 lymphangitis 10.2
39 eales disease 10.2 IFNG TF
40 central nervous system vasculitis 10.2 HLA-DRB1 IFNG
41 chronic inflammatory demyelinating polyradiculoneuropathy 10.2 HLA-DRB1 IFNG
42 polyradiculoneuropathy 10.2 HLA-DRB1 IFNG
43 iron overload in africa 10.2 HLA-A TF
44 peanut allergy 10.2 HLA-DRB1 IFNG
45 choroiditis 10.2
46 separation anxiety disorder 10.2 HLA-A HLA-B
47 vernal conjunctivitis 10.1 IFNG TF
48 chronic graft versus host disease 10.1 IFNG MICA
49 cytomegalovirus retinitis 10.1 HLA-A HLA-B IFNG
50 hematopoietic stem cell transplantation 10.1 HLA-A HLA-B IFNG

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to Histoplasmosis

Symptoms & Phenotypes for Histoplasmosis

UMLS symptoms related to Histoplasmosis:


fever, pruritus

GenomeRNAi Phenotypes related to Histoplasmosis according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.07 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.07 MICA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.07 HLA-A HLA-B HLA-DQA1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.07 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.07 HLA-DQA1 MICA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.07 HLA-DQA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.07 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.07 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.07 HLA-A HLA-B HLA-DQA1 MICA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.07 HLA-A HLA-B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-45 10.07 HLA-DQA1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.07 MICA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.07 MICA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.07 HLA-A HLA-B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.07 HLA-DQA1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.07 HLA-A HLA-B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.07 MICA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.07 HLA-DQA1

Drugs & Therapeutics for Histoplasmosis

Drugs for Histoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
3
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
4
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
5
Nevirapine Approved Phase 4 129618-40-2 4463
6
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
7 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
9 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
10 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
11 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
13 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
15 Antiviral Agents Phase 4,Phase 3
16 Nucleic Acid Synthesis Inhibitors Phase 4
17 HIV Protease Inhibitors Phase 4,Phase 3,Not Applicable
18 Anti-HIV Agents Phase 4,Phase 3
19 Cytochrome P-450 CYP3A Inducers Phase 4
20 Atazanavir Sulfate Phase 4,Phase 3
21 Reverse Transcriptase Inhibitors Phase 4
22 Anti-Retroviral Agents Phase 4,Phase 3
23
protease inhibitors Phase 4,Phase 3,Not Applicable
24 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
25
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
26
Itraconazole Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 84625-61-6 55283
27
Bevacizumab Approved, Investigational Phase 3,Not Applicable 216974-75-3
28
Fluconazole Approved, Investigational Phase 3,Phase 2,Not Applicable 86386-73-4 3365
29
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
30
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
31 tannic acid Approved Phase 3
32
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
33
Adalimumab Approved Phase 3 331731-18-1 16219006
34 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
35 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1,Not Applicable
36 Liposomal amphotericin B Phase 3
37 Antiparasitic Agents Phase 3
38
Hydroxyitraconazole Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Antibiotics, Antitubercular Phase 3
40 Antiprotozoal Agents Phase 3
41 Anti-Bacterial Agents Phase 3
42 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2,Not Applicable
43 Cytochrome P-450 CYP2C19 Inhibitors Phase 3,Phase 2,Not Applicable
44 Pharmaceutical Solutions Phase 3,Early Phase 1
45 Peripheral Nervous System Agents Phase 3,Not Applicable
46 Analgesics Phase 3
47 Interleukin-2 Phase 3
48 Analgesics, Non-Narcotic Phase 3
49 Antibodies Phase 3
50 Antibodies, Monoclonal Phase 3

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
2 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
3 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
4 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
5 Submacular Surgery Trials (SST) Completed NCT00000150 Phase 3
6 A Multi-center Study of Spherule-Derived Coccidioidin Completed NCT00690092 Phase 3
7 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
8 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
9 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
10 PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) Completed NCT01099579 Phase 3 Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
11 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
12 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
13 Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease Completed NCT00195715 Phase 3
14 Treatment for Presumed Ocular Histoplasmosis Unknown status NCT01790893 Phase 1, Phase 2 aflibercept
15 Ranibizumab Versus PDT for Presumed Ocular Histoplasmosis Unknown status NCT00546936 Phase 2 ranibizumab;verteporfin
16 Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome Unknown status NCT00955630 Phase 1, Phase 2 ranibizumab;ranibizumab
17 A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000975 Phase 2 Itraconazole
18 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
19 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
20 Intravitreal Aflibercept Injection (IAI) for Presumed Ocular Histoplasmosis Syndrome Completed NCT01578720 Phase 1 EYLEA (Aflibercept) intravitreal injection
21 A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000992 Phase 1 Itraconazole
22 A Clinical Study to Evaluate the Pharmacokinetics of Lozanoc and Sporanox in Korean Healthy Male Volunteers Completed NCT02493738 Phase 1 Lozanoc 50mg;Sporanox 100mg
23 Withdrawal of Antifungal Treatment for Histoplasmosis in Patients After Improved Immune Response to Anti-HIV Drugs Completed NCT00006316
24 A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients Completed NCT00002438 Not Applicable Itraconazole
25 Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000627 Not Applicable Fluconazole
26 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697
27 A Comparison of HIV-Infected Patients With and Without Opportunistic (AIDS-Related) Infection Completed NCT00005572
28 HIV Cohort Study At Johns Hopkins University, University of North Carolina at Chapel Hill and Vanderbilt University Completed NCT01339416
29 Postmarketing Safety Surveillance European Registry of Crohn's Disease Patients Treated With Remicade or Standard Therapy (MK-2155-035) Completed NCT00705614
30 Kaiser Permanente HIV Cohort Study Completed NCT01339403
31 Observational Safety Study of Etanercept (Enbrel) for Treatment of Psoriasis Completed NCT00322439 Etanercept
32 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Recruiting NCT02120677 Early Phase 1 Itraconazole
33 Prevalence of Histoplasmosis in HIV + Patients With a Rapid Diagnostic Test in West Indies Active, not recruiting NCT01884779
34 Macugen for Histoplasmosis Terminated NCT00272766 Not Applicable pegaptanib sodium
35 Additive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, Panama Withdrawn NCT02911740 Not Applicable
36 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Histoplasmosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: histoplasmosis

Genetic Tests for Histoplasmosis

Anatomical Context for Histoplasmosis

MalaCards organs/tissues related to Histoplasmosis:

41
Lung, Testes, Bone, Colon, Skin, Bone Marrow, Kidney

Publications for Histoplasmosis

Articles related to Histoplasmosis:

(show top 50) (show all 1209)
# Title Authors Year
1
Colonic perforation due to GI histoplasmosis in an immunocompetent host mimicking Crohn's disease. ( 29337040 )
2018
2
Disseminated histoplasmosis in an immunocompetent patient - utility of skin scrape cytology in diagnosis: a case report. ( 29325597 )
2018
3
An exuberant form of disseminated histoplasmosis. ( 29936098 )
2018
4
Sepsis-like histoplasmosis in a kidney transplant patient. ( 29738029 )
2018
5
Not Your Typical Arizona Granuloma: A Case Report of Disseminated Histoplasmosis. ( 29730356 )
2018
6
Clinical outcomes and risk factors for death from disseminated histoplasmosis in patients with AIDS who visited a high-complexity hospital in Campo Grande, MS, Brazil. ( 29768547 )
2018
7
Fibrosing Mediastinitis: Uncommon Life-threatening Complication of Histoplasmosis. ( 29946500 )
2018
8
Histoplasmosis in Africa: An emerging or a neglected disease? ( 29346384 )
2018
9
Central nervous system histoplasmosis: Multicenter retrospective study on clinical features, diagnostic approach and outcome of treatment: Erratum. ( 29668643 )
2018
10
Sepsis-like histoplasmosis in a kidney transplant patient. ( 29796577 )
2018
11
Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. ( 29319442 )
2018
12
Adrenal Histoplasmosis. ( 29762233 )
2018
13
Ileum Histoplasmosis Mimicking Intestinal Tuberculosis and Crohn's Disease. ( 29515346 )
2018
14
Disseminated histoplasmosis mimicking relapsed chronic lymphocytic leukaemia. ( 29954761 )
2018
15
Chronic Pulmonary Histoplasmosis Identified in a Young Patient with Selective Immunoglobulin M Deficiency. ( 29888016 )
2018
16
Prior subclinical histoplasmosis revealed in Nigeria using histoplasmin skin testing. ( 29742119 )
2018
17
The important role of co-infections in patients with AIDS and progressive disseminated histoplasmosis (PDH): A cohort from Colombia. ( 29379705 )
2018
18
Unexpected disseminated histoplasmosis detected by bone marrow biopsy in a solid organ transplant patient. ( 29375836 )
2018
19
Gastrointestinal histoplasmosis ileal stricture successfully treated with through-the-scope balloon dilation in a patient with hyperimmunoglobulin M syndrome. ( 29340926 )
2018
20
Oropharyngeal histoplasmosis: The diagnosis lies in the biopsy. ( 29276680 )
2018
21
PRN Ranibizumab in the Treatment of Choroidal Neovascularization Secondary to Ocular Histoplasmosis. ( 29304262 )
2018
22
Diagnosis and treatment of histoplasmosis in solid organ transplant patients. ( 29738315 )
2018
23
Concurrent<i>Pneumocystis jirovecii</i>and pulmonary histoplasmosis in an undiagnosed HIV patient. ( 29374650 )
2018
24
Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis in the setting of Acquired Immunodeficiency Syndrome (AIDS). ( 29657917 )
2018
25
Cave diving for a diagnosis: Disseminated histoplasmosis in the immunocompromised. ( 29942759 )
2018
26
Unilateral adrenal histoplasmosis. ( 29888193 )
2018
27
Hemophagocytic lymphohistiocytosis in an HIV-positive patient with concomitant disseminated histoplasmosis. ( 29433397 )
2018
28
Out of town guest: A healthy 7 year old from a non-endemic area presents with histoplasmosis granulomatous disease. ( 29942767 )
2018
29
Disseminated Histoplasmosis Diagnosed on Bone Marrow Aspiration in a Case of Fever with Thrombocytopenia. ( 29910573 )
2018
30
Histoplasmosis: An oral malignancy-like clinical picture. ( 29379706 )
2018
31
African Histoplasmosis in HIV-Negative Patients, Kimpese, Democratic Republic of the Congo. ( 30334708 )
2018
32
Epidemiology and Geographic Distribution of Blastomycosis, Histoplasmosis, and Coccidioidomycosis, Ontario, Canada, 1990-2015. ( 29912691 )
2018
33
A rare case of disseminated histoplasmosis in a patient with Crohn's disease on immunosuppressive treatment. ( 30168074 )
2018
34
Disseminated Histoplasmosis: An Unusual Presentation of a Classic Midwest Infection. ( 29030061 )
2018
35
Case Report: Histoplasmosis: First Autochthonous Case from Israel. ( 29165228 )
2018
36
Outbreak of Severe Histoplasmosis Among Tunnel Workers-Dominican Republic, 2015. ( 29211836 )
2018
37
Pulmonary Histoplasmosis Identified by Video-Assisted Thoracic Surgery (VATS) Biopsy: a Case Report. ( 29215824 )
2018
38
Fast protocol for the production of Histoplasma capsulatum antigens for antibody detection in the immunodiagnosis of histoplasmosis. ( 29217126 )
2018
39
Histoplasmosis: An Emerging Endemic Mycosis. ( 29217227 )
2018
40
Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States. ( 29228334 )
2018
41
Multistate Epidemiology of Histoplasmosis, United States, 2011-2014 ( 29460731 )
2018
42
Pretreatment Histoplasma capsulatum urine enzymatic immunoassay concentrations do not correlate with outcome but may be influenced by renal function in cats with histoplasmosis. ( 29513156 )
2018
43
Disseminated histoplasmosis diagnosed in the bone marrow of an HIV-infected patient: First case imported in Tunisia. ( 29519625 )
2018
44
Unusual cause of infant pancytopenia: granulomatous bone marrow lesion with disseminated histoplasmosis. ( 29519931 )
2018
45
A Case of Disseminated Histoplasmosis in a Patient with Rheumatoid Arthritis on Abatacept. ( 29532302 )
2018
46
Gastrointestinal Histoplasmosis Presenting as an Acute Abdomen with Jejunal Perforation. ( 29535767 )
2018
47
Multicenter Validation of Commercial Antigenuria Reagents To Diagnose Progressive Disseminated Histoplasmosis in People Living with HIV/AIDS in Two Latin American Countries. ( 29563205 )
2018
48
A proposal for antifungal epidemiological cut-off values against Histoplasma capsulatum var. capsulatum based on the susceptibility of isolates from HIV-infected patients with disseminated histoplasmosis in Northeast Brazil. ( 29592837 )
2018
49
Central nervous system histoplasmosis: Multicenter retrospective study on clinical features, diagnostic approach and outcome of treatment. ( 29595679 )
2018
50
Histoplasmosis Myocarditis in an Immunocompetent Host After a Recreational Mud Run. ( 29610172 )
2018

Variations for Histoplasmosis

Expression for Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for Histoplasmosis

Pathways related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 ATP6V1A C3 EGF HLA-A HLA-B HLA-DQA1
2
Show member pathways
13.16 C3 EGF HLA-A HLA-B HLA-DQA1 HLA-DRB1
3
Show member pathways
13.14 EGF HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
4
Show member pathways
12.77 HLA-A HLA-B HLA-DQA1 HLA-DRB1
5
Show member pathways
12.77 ATP6V1A EGF HLA-A HLA-B
6
Show member pathways
12.32 HLA-A HLA-B IFNG MICA
7
Show member pathways
12.32 C3 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
8 12.24 HLA-A HLA-B HLA-DQA1 HLA-DRB1
9
Show member pathways
12.24 C3 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
10
Show member pathways
12.21 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
11 12.1 C3 HLA-A HLA-B
12 12.1 HLA-A HLA-B HLA-DQA1 HLA-DRB1
13
Show member pathways
12.05 C3 HLA-DQA1 HLA-DRB1 IFNG
14 12.01 C3 HLA-DQA1 HLA-DRB1 IFNG
15 11.86 HLA-A HLA-B HLA-DQA1 HLA-DRB1
16
Show member pathways
11.81 HLA-A HLA-DRB1 IFNG
17 11.8 C3 HLA-A HLA-B MICA
18 11.74 EGF HLA-DQA1 HLA-DRB1
19 11.74 EGF IFNG TF
20
Show member pathways
11.73 EGF HLA-DQA1 HLA-DRB1
21 11.51 ATP6V1A HLA-DQA1 HLA-DRB1 IFNG
22 11.43 C3 HLA-DQA1 HLA-DRB1
23 11.28 ATP6V1A C3 HLA-A HLA-B HLA-DQA1 HLA-DRB1
24 11.19 HLA-B IFNG
25 11.07 HLA-DRB1 IFNG
26 11.05 HLA-DRB1 IFNG
27 10.99 HLA-A HLA-B

GO Terms for Histoplasmosis

Cellular components related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 ATP6V1A C3 EGF HLA-A HLA-B HLA-DRB1
2 Golgi membrane GO:0000139 9.73 HLA-A HLA-B HLA-DQA1 HLA-DRB1
3 endosome membrane GO:0010008 9.65 HLA-DQA1 HLA-DRB1 TF
4 lysosomal membrane GO:0005765 9.56 ATP6V1A EGF HLA-DQA1 HLA-DRB1
5 cell surface GO:0009986 9.55 HLA-A HLA-B HLA-DRB1 MICA TF
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.46 HLA-DQA1 HLA-DRB1
7 MHC class II protein complex GO:0042613 9.4 HLA-DQA1 HLA-DRB1
8 MHC class I protein complex GO:0042612 9.37 HLA-A HLA-B
9 ER to Golgi transport vesicle membrane GO:0012507 9.26 HLA-A HLA-B HLA-DQA1 HLA-DRB1
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.92 HLA-A HLA-B HLA-DQA1 HLA-DRB1

Biological processes related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 C3 HLA-A HLA-B HLA-DQA1 HLA-DRB1
2 regulation of immune response GO:0050776 9.56 C3 HLA-A HLA-B MICA
3 retina homeostasis GO:0001895 9.54 ARMS2 TF
4 transferrin transport GO:0033572 9.52 ATP6V1A TF
5 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.51 HLA-A HLA-B
6 immune response GO:0006955 9.5 C3 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.49 HLA-A HLA-B
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.48 HLA-A HLA-B
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.46 HLA-DQA1 HLA-DRB1
10 antigen processing and presentation GO:0019882 9.46 HLA-A HLA-B HLA-DQA1 HLA-DRB1
11 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.43 HLA-A HLA-B
12 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.4 HLA-A HLA-B
13 protection from natural killer cell mediated cytotoxicity GO:0042270 9.32 HLA-A HLA-B
14 interferon-gamma-mediated signaling pathway GO:0060333 9.02 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IFNG

Molecular functions related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.16 HLA-DQA1 HLA-DRB1
2 beta-2-microglobulin binding GO:0030881 8.96 HLA-A MICA
3 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-DQA1 HLA-DRB1

Sources for Histoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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