MCID: HST011
MIFTS: 54

Histoplasmosis

Categories: Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Histoplasmosis

MalaCards integrated aliases for Histoplasmosis:

Name: Histoplasmosis 12 73 58 42 3 44 15 17 70 32
Infection by Histoplasma Capsulatum 70
Reticuloendotheliosis, X-Linked 44
Darling Disease 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1731
ICD9CM 34 115
SNOMED-CT 67 266218008
ICD10 32 B39 B39.9
MESH via Orphanet 45 D006660
ICD10 via Orphanet 33 B39.0 B39.1 B39.2 more
UMLS via Orphanet 71 C0019655 C0153261
Orphanet 58 ORPHA390
UMLS 70 C0019655 C0035288 C0153261

Summaries for Histoplasmosis

MedlinePlus : 42 Histoplasmosis is a disease caused by a fungus (or mold) called Histoplasma. The fungus is common in the eastern and central United States. It grows in soil and material contaminated with bat or bird droppings. You get infected by breathing the fungal spores. You cannot get the infection from someone else. Histoplasmosis is often mild, with no symptoms. If you do get sick, it usually affects your lungs. Symptoms include feeling ill, fever, chest pains, and a dry cough. In severe cases, histoplasmosis spreads to other organs. This is called disseminated disease. It is more common in infants, young children, older adults, and people with immune system problems. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. Mild cases usually get better without treatment. Treatment of severe or chronic cases is with antifungal drugs. Centers for Disease Control and Prevention

MalaCards based summary : Histoplasmosis, also known as infection by histoplasma capsulatum, is related to blastomycosis and primary adrenal insufficiency, and has symptoms including headache, nonproductive cough and loss of appetite. An important gene associated with Histoplasmosis is STAT1 (Signal Transducer And Activator Of Transcription 1), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Itraconazole and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A primary systemic mycosis that results in systemic fungal infection, has material basis in Histoplasma capsulatum var capsulatum or has material basis in Histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC : 3 Histoplasmosis is an infection caused by a fungus called Histoplasma. The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings. In the United States, Histoplasma mainly lives in the central and eastern states, especially areas around the Ohio and Mississippi River valleys. The fungus also lives in parts of Central and South America, Africa, Asia, and Australia. People can get histoplasmosis after breathing in the microscopic fungal spores from the air. Although most people who breathe in the spores don't get sick, those who do may have a fever, cough, and fatigue. Many people who get histoplasmosis will get better on their own without medication, but in some people, such as those who have weakened immune systems, the infection can become severe.

Wikipedia : 73 Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum. Symptoms of this infection vary... more...

Related Diseases for Histoplasmosis

Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 724)
# Related Disease Score Top Affiliating Genes
1 blastomycosis 30.5 CLEC7A CD4 CCR6
2 primary adrenal insufficiency 30.5 HLA-DRB1 HLA-DQA1
3 acquired immunodeficiency syndrome 30.4 TNF IFNG HLA-B CD4 CCR6
4 erythema nodosum 30.2 TNF IFNG C3
5 leishmaniasis 30.2 TNF IFNG HLA-DRB1 HLA-DQA1
6 toxoplasmosis 30.2 TNF STAT1 IFNG HLA-DQA1
7 paracoccidioidomycosis 30.2 TNF IL12RB1 IFNG
8 uveitis 30.2 TNF IFNG HLA-B HLA-A
9 multifocal choroiditis 30.1 TNF CFH ARMS2
10 osteomyelitis 30.0 TNF STAT1 IFNG
11 penicilliosis 30.0 IFNG CLEC7A CD4
12 pars planitis 30.0 HLA-DRB1 HLA-B HLA-A CCR6
13 sporotrichosis 30.0 IFNG CLEC7A CD4
14 human immunodeficiency virus type 1 29.9 TNF STAT1 IFNG HLA-B HLA-A CD4
15 candidiasis 29.9 TNF STAT1 IFNG CLEC7A
16 cryptococcal meningitis 29.9 IFNG CD4 CCR6
17 coccidioidomycosis 29.9 STAT1 IL12RB1 CLEC7A CD4 CCR6
18 purpura 29.9 TNF IFNG C3
19 meningitis 29.9 TNF IFNG HLA-B C3
20 diarrhea 29.9 TNF STAT1 IFNG C3
21 lupus erythematosus 29.8 TNF IFNG HLA-DRB1 HLA-DQA1 C3
22 myositis 29.8 TNF IFNG HLA-DRB1 HLA-DQA1 HLA-B
23 chorioretinitis 29.8 TNF IFNG CD4
24 thrombocytopenic purpura, autoimmune 29.8 HLA-DRB1 CD4 CCR6
25 choroiditis 29.8 TNF IFNG CFH CD4 ARMS2
26 crohn's colitis 29.8 TNF IFNG CCR6
27 panniculitis 29.8 TNF IFNG CD4
28 chromoblastomycosis 29.8 HLA-A CLEC7A CCR6
29 panophthalmitis 29.7 IFNG CD4
30 exanthem 29.7 TNF IFNG CD4 CCR6
31 aphthous stomatitis 29.7 TNF IFNG HLA-DRB1 HLA-B HLA-A
32 pulmonary tuberculosis 29.7 TNF IL12RB1 IFNG HLA-DRB1 C3
33 crohn's disease 29.6 TNF IFNG HLA-DRB1 CD4 CCR6
34 disease by infectious agent 29.6 TNF IFNG CD4 CCR6
35 miliary tuberculosis 29.6 TNF IL12RB1 IFNG CD4
36 invasive aspergillosis 29.6 IFNG CLEC7A CCR6
37 cellulitis 29.6 TNF CD4 CCR6
38 oral candidiasis 29.6 STAT1 CLEC7A CD4 CCR6
39 optic neuritis 29.5 TNF HLA-DRB1 HLA-DQA1 HLA-A
40 aspergillosis 29.5 TNF IFNG CLEC7A CCR6
41 neuritis 29.5 TNF IFNG HLA-DRB1 HLA-DQA1
42 cryptococcosis 29.5 TNF IFNG CLEC7A CD4 CCR6
43 rheumatoid arthritis 29.4 TNF IFNG HLA-DRB1 HLA-DQA1 HLA-B CCR6
44 iridocyclitis 29.4 TNF HLA-B CD4
45 scleritis 29.4 TNF IFNG CCR6
46 conjunctivitis 29.4 TNF IFNG HLA-B
47 rosacea 29.4 TNF STAT1 CCR6
48 visceral leishmaniasis 29.4 TNF IL12RB1 IFNG HLA-DRB1 HLA-DQA1
49 thrombocytopenia 29.4 TNF STAT1 IFNG HLA-B HLA-A CFH
50 intestinal tuberculosis 29.4 TNF IFNG CD4

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to Histoplasmosis

Symptoms & Phenotypes for Histoplasmosis

Symptoms:

12
  • headache
  • nonproductive cough
  • loss of appetite
  • muscle pains

UMLS symptoms related to Histoplasmosis:


fever; pruritus

GenomeRNAi Phenotypes related to Histoplasmosis according to GeneCards Suite gene sharing:

26 (show all 46)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-101 10.1 CLEC7A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.1 CLEC7A HLA-A HLA-B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 10.1 HLA-A HLA-B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 10.1 CLEC7A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 10.1 CLEC7A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 10.1 CLEC7A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 10.1 CLEC7A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 10.1 HLA-A HLA-B
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 10.1 CLEC7A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 10.1 HLA-A HLA-B
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 10.1 HLA-A HLA-B
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.1 CLEC7A
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-205 10.1 CLEC7A
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 10.1 CLEC7A
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 10.1 CLEC7A
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 10.1 HLA-A HLA-B
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 10.1 HLA-A HLA-B
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 10.1 CLEC7A
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.1 CLEC7A
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 10.1 CLEC7A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.8 SLC17A5
22 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.8 MICA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.8 HLA-DQA1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.8 SLC17A5
25 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.8 HLA-A HLA-B
26 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.8 MICA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.8 SLC17A5
28 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.8 SLC17A5
29 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.8 SLC17A5
30 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.8 MICA SLC17A5
31 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.8 CD4
32 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.8 CD4
33 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.8 CD4
34 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.8 CD4 SLC17A5
35 Increased shRNA abundance (Z-score > 2) GR00366-A-193 9.8 HLA-DQA1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.8 CD4
37 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.8 SLC17A5
38 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.8 HLA-DQA1
39 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.8 MICA
40 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.8 SLC17A5
41 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.8 MICA
42 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.8 HLA-DQA1
43 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.8 HLA-A HLA-B
44 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.8 SLC17A5
45 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.8 MICA
46 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.8 HLA-DQA1

MGI Mouse Phenotypes related to Histoplasmosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 C3 CCR6 CD4 CFH CLEC7A HLA-A
2 immune system MP:0005387 9.47 C3 CCR6 CD4 CFH CLEC7A EGF

Drugs & Therapeutics for Histoplasmosis

Drugs for Histoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
2
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
3
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
5 Cytochrome P-450 Enzyme Inhibitors Phase 3
6 Anti-Infective Agents Phase 3
7 Cytochrome P-450 CYP3A Inhibitors Phase 3
8
Hydroxyitraconazole Phase 3 108222
9 Pharmaceutical Solutions Phase 3
10 Amebicides Phase 3
11 Antiparasitic Agents Phase 3
12 Anti-Bacterial Agents Phase 3
13 Antiprotozoal Agents Phase 3
14 Liposomal amphotericin B Phase 3
15 Antibiotics, Antitubercular Phase 3
16 Antifungal Agents Phase 3
17
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
18
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
19
Ketoconazole Approved, Investigational Phase 1 65277-42-1 47576
20
Petrolatum Approved, Investigational Early Phase 1 8009-03-8
21 Anti-Retroviral Agents
22 Anti-HIV Agents

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
2 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
3 Safety, Sensitivity and Specificity of Spherule-derived Coccidioidin in Naive Adults, in Adults With a History of Pulmonary Coccidioidomycosis and in Adults With a History of Pulmonary Histoplasmosis Completed NCT00690092 Phase 3
4 Submacular Surgery Trials (SST) Completed NCT00000150 Phase 3
5 A Pharmacokinetic Study of JK1211 in Patients With Systemic Fungal Infection (SFI) and Patients With Febrile Neutropenia (FN) Suspected of Fungal Infection. Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
6 Open-Label Study to Evaluate the Efficacy and Safety of SCY-078 (Ibrexafungerp) in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment (FURI) Recruiting NCT03059992 Phase 3 Ibrexafungerp
7 Intravitreal Aflibercept Injection for the Treatment of cHoroidAl Neovascularization seconDary to Presumed ocuLar Histoplasmosis syndromE.(the HANDLE Study) Unknown status NCT01790893 Phase 1, Phase 2 aflibercept
8 Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome Unknown status NCT00955630 Phase 1, Phase 2 ranibizumab;ranibizumab
9 Ranibizumab vs PDT for Presumed Ocular Histoplasmosis Unknown status NCT00546936 Phase 2 ranibizumab;verteporfin
10 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
11 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
12 Pilot Study To Determine the Feasibility of Itraconazole for Primary Treatment and Suppression of Relapse of Disseminated Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000975 Phase 2 Itraconazole
13 Open Label Phase-II Randomized Trial of Three Liposomal Amphotericin B Regimens as Induction Therapy for Disseminated Histoplasmosis in AIDS Patients Not yet recruiting NCT04059770 Phase 2 single dose of L-AmB;2 doses of L-AmB;2 weeks of L-AmB
14 Pilot Study to Determine the Feasibility of Itraconazole for Suppression of Relapse of Disseminated Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000992 Phase 1 Itraconazole
15 Treatment of CNV Secondary to Presumed Ocular Histoplasmosis With EYLEA 2.0mg (Intravitreal Aflibercept Injection) Completed NCT01578720 Phase 1 EYLEA (Aflibercept) intravitreal injection
16 A Phase I Single-Center, Randomized, Open-label, Single Dose, Crossover Study in Korean Healthy Male Volunteers to Evaluate Pharmacokinetics of Lozanoc and Sporanox Completed NCT02493738 Phase 1 Lozanoc 50mg;Sporanox 100mg
17 Histoplasmosis in the Guiana Shield and the French West Indies: Evaluating Prevalence in HIV + Patients With a Rapid Diagnostic Test Using an ELISA Capture Method for the Detection of Histoplasma Antigens in Blood and Urine. Unknown status NCT01884779
18 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization: Multicenter Collaborative Study Completed NCT00645697
19 A Pilot Study Investigating Antitumorigenic Potential of Topical Itraconazole in the Treatment of Basal Cell Carcinoma Completed NCT02120677 Early Phase 1 Itraconazole
20 Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000627 Fluconazole
21 Discontinuation of Antifungal Therapy for Histoplasmosis Following Immunologic Response to Antiretroviral Therapy Completed NCT00006316
22 Randomized Study Comparing Itraconazole to Placebo in the Prevention of Histoplasmosis in Patients With Human Immunodeficiency Virus Infection Completed NCT00002438 Itraconazole
23 Macugen for Histoplasmosis-An Open-Label, Single-Site, Comparative, Prospective Case Series Terminated NCT00272766 pegaptanib sodium
24 Pilot Study of Intravitreal Bevacizumab vs. Combination Therapy for Choroidal Neovascularization Secondary to Causes Other Than Age-related Macular Degeneration Withdrawn NCT01256580 Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy
25 Investigating the Additive Benefit of the Urine Lipoarabinomannan Test to Current TB Diagnostics Among HIV+ Adults in Panama City, Panama Withdrawn NCT02911740

Search NIH Clinical Center for Histoplasmosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Fluconazole
Itraconazole
Ketoconazole

Cochrane evidence based reviews: histoplasmosis

Genetic Tests for Histoplasmosis

Anatomical Context for Histoplasmosis

MalaCards organs/tissues related to Histoplasmosis:

40
Skin, Bone, Bone Marrow, Kidney, Liver, Eye, Tongue

Publications for Histoplasmosis

Articles related to Histoplasmosis:

(show top 50) (show all 5560)
# Title Authors PMID Year
1
Temporal trends of cutaneo-mucous histoplasmosis in persons living with HIV in French Guiana: Early diagnosis defuses South American strain dermotropism. 42 61
33075084 2020
2
Disseminated Histoplasmosis: Fighting a neglected killer of patients with advanced HIV disease in Latin America. 61 42
32407383 2020
3
What is AIDS in the Amazon and the Guianas in the 90-90-90 era? 61 42
32706836 2020
4
Disseminated Histoplasmosis in a Patient With Multiple Sclerosis Treated With Fingolimod. 61
33602716 2021
5
Case Report: Incidental Finding of COVID-19 Infection after Positron Emission Tomography/CT Imaging in a Patient with a Diagnosis of Histoplasmosis and Recurring Fever. 61
33798100 2021
6
A case report of gastrointestinal histoplasmosis in a patient treated with infliximab. 61
33231849 2021
7
Not Your Everyday Cecal Nodule: Disseminated Histoplasmosis in a HIV Negative Renal Transplant Patient. 61
33531162 2021
8
Central Nervous System Histoplasma-Associated Post-infectious Inflammatory Response Syndrome (Histo-PIIRS). 61
33387157 2021
9
Epidemiology and Clinical Characteristics of Presumed Ocular Histoplasmosis in Olmsted County, Minnesota. 61
33661067 2021
10
Diagnosis of histoplasmosis: current status and perspectives. 61
33587157 2021
11
Rare clinical presentation of histoplasmosis. 61
33095476 2021
12
Thoracic Endemic Fungi in the United States: Importance of Patient Location. 61
33544664 2021
13
A global view on fungal infections in humans and animals: Infections caused by dimorphic fungi and dermatophytoses. 61
33754409 2021
14
Clinical Significance and Histologic Characterization of Histoplasma Granulomas. 61
33089308 2021
15
Complex and Controversial Roles of Eicosanoids in Fungal Pathogenesis. 61
33800694 2021
16
Evaluation of a New Histoplasma spp. Quantitative RT-PCR Assay. 61
33706012 2021
17
Estimates of serious fungal infection burden in Côte d'Ivoire and country health profile. 61
33259981 2021
18
Prevalence of pulmonary mycoses in smear-negative patients with suspected tuberculosis in the Brazilian Amazon. 61
33775537 2021
19
Comparison of Blood (1->3)-β-D-Glucan Levels in AIDS-Related Pneumocystis jirovecii Pneumonia and AIDS-Related Progressive Disseminated Histoplasmosis. 61
33786591 2021
20
Diagnostic accuracy of antigen detection in urine and molecular assays testing in different clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: A prospective multicenter study in Mexico. 61
33684128 2021
21
COVID-19-Associated Histoplasmosis in an AIDS Patient. 61
33156463 2021
22
Less Common Respiratory Conditions: Fungal Respiratory Infections. 61
33683851 2021
23
Autochthonous Case of Pulmonary Histoplasmosis, Switzerland. 61
33622462 2021
24
Disseminated Histoplasmosis Presenting as Weight Loss and Hypercalcemia in a Renal Transplant Patient With Prior History of Subtotal Parathyroidectomy. 61
33729918 2021
25
Progressive disseminated histoplasmosis in children living with HIV: a case series study. 61
33555424 2021
26
Validation of Histoplasmosis Enzyme Immunoassay to Evaluate Suspicious Lung Nodules. 61
32682756 2021
27
Disseminated histoplasmosis in a kidney transplant patient. 61
32654347 2021
28
Health Care Providers' Testing Practices for Coccidioidomycosis and Histoplasmosis in Patients With Community-Acquired Pneumonia-United States, 2020. 61
33575429 2021
29
Cutaneous Histoplasmosis in HIV Seronegative Patients: A Clinicopathological Analysis. 61
33626536 2021
30
Hemophagocytic lymphohistiocytosis (HLH) caused by disseminated histoplasmosis by H. capsulatum var. duboisii in HIV patient: A case report. 61
32446648 2021
31
The microbiome of bat guano: for what is this knowledge important? 61
33512572 2021
32
Prosthetic Joint Infections Due to Histoplasma capsulatum: A Report of 3 Cases. 61
33718797 2021
33
Peptidogalactomannan from Histoplasma capsulatum yeast cell wall: role of the chemical structure in recognition and activation by peritoneal macrophages. 61
33611739 2021
34
A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil. 61
33597620 2021
35
The impact of COVID-19 pandemic on AIDS-related mycoses and fungal neglected tropical diseases: Why should we worry? 61
33561159 2021
36
A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis. 61
33786224 2021
37
Pulmonary Histoplasmosis Mimicking Metastatic Lung Cancer: A Case Report. 61
33671319 2021
38
Successful application of pharmacogenomic testing in the evaluation and management of a patient with human immunodeficiency virus and disseminated histoplasmosis. 61
33583749 2021
39
Summary of Guidelines for Managing Histoplasmosis among People Living with HIV. 61
33673384 2021
40
Histoplasmosis tenosynovitis of the forearm and wrist: imaging, surgical and pathologic findings. 61
33537878 2021
41
Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis in Rheumatologic Disease. 61
33552603 2021
42
Histoplasmosis and inflammatory bowel disease: A case report. 61
33520104 2021
43
Histoplasmosis in Inflammatory Bowel Disease with Tumor Necrosis Factor-Alpha Inhibitors: Safe to Continue Biologics? 61
32144603 2021
44
Gastrointestinal disseminated histoplasmosis in HIV-infected patients: A descriptive and comparative study. 61
33481806 2021
45
Deep mycoses and pseudomycoses of the foot: a single-center retrospective study of 160 cases, in a tertiary-care center in Mexico. 61
33453613 2021
46
HIV-Associated Disseminated Histoplasmosis and Rare Adrenal Involvement: Evidence of Absence or Absence of Evidence. 61
33791237 2021
47
Evaluation of a novel monoclonal antibody-based enzyme immunoassay for detection of Histoplasma antigen in urine of dogs. 61
33368653 2021
48
Differential miRNA Expression in Human Macrophage-Like Cells Infected with Histoplasma capsulatum Yeasts Cultured in Planktonic and Biofilm Forms. 61
33477397 2021
49
Etiological profile and main imaging findings in patients with granulomatous diseases who underwent lung biopsy. 61
33521170 2021
50
Cerebral histoplasmosis caused by Histoplasma capsulatum var. duboisii in a patient with no known immunodeficiency. 61
32956441 2021

Variations for Histoplasmosis

Expression for Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for Histoplasmosis

Pathways related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 TNF STAT1 MICA IL12RB1 IFNG HLA-DRB1
2
Show member pathways
13.45 MICA HLA-DRB1 HLA-DQA1 HLA-B HLA-A EGF
3
Show member pathways
13.33 TNF STAT1 IL12RB1 IFNG HLA-DRB1 HLA-DQA1
4
Show member pathways
12.98 TNF STAT1 HLA-B HLA-A EGF ATP6V1A
5
Show member pathways
12.93 TNF STAT1 MICA HLA-B HLA-A CD4
6
Show member pathways
12.8 TNF STAT1 IFNG HLA-DRB1 HLA-DQA1 HLA-B
7 12.67 TNF STAT1 IFNG HLA-DRB1 HLA-DQA1 HLA-B
8
Show member pathways
12.65 TNF STAT1 IFNG EGF CD4
9
Show member pathways
12.63 TNF IL12RB1 IFNG HLA-DRB1 HLA-DQA1 CD4
10
Show member pathways
12.59 TNF STAT1 IFNG EGF CD4
11
Show member pathways
12.57 TNF STAT1 IL12RB1 IFNG CD4
12
Show member pathways
12.54 STAT1 IFNG HLA-DRB1 HLA-DQA1 HLA-B HLA-A
13
Show member pathways
12.54 TNF STAT1 IL12RB1 IFNG HLA-DRB1 HLA-DQA1
14
Show member pathways
12.5 TNF MICA IFNG HLA-B HLA-A
15
Show member pathways
12.38 STAT1 IL12RB1 IFNG EGF
16 12.35 TNF HLA-DRB1 HLA-DQA1 HLA-B HLA-A CD4
17
Show member pathways
12.25 TNF STAT1 IFNG HLA-B HLA-A
18
Show member pathways
12.23 TNF STAT1 IFNG HLA-DRB1 HLA-DQA1 C3
19 12.18 TNF STAT1 IFNG EGF
20 12.13 HLA-DRB1 HLA-DQA1 HLA-B HLA-A CD4
21 12.07 MICA HLA-B HLA-A C3
22
Show member pathways
12.06 TNF STAT1 MICA IFNG HLA-DRB1 HLA-DQA1
23 11.96 TNF STAT1 IFNG HLA-DRB1 HLA-DQA1 CLEC7A
24 11.93 HLA-DRB1 HLA-DQA1 EGF CD4
25 11.91 TNF HLA-DRB1 HLA-DQA1 CD4
26 11.89 HLA-DRB1 HLA-DQA1 CFH C3
27 11.88 TNF IFNG HLA-DRB1 HLA-DQA1 ATP6V1A
28
Show member pathways
11.86 STAT1 IL12RB1 IFNG CD4
29
Show member pathways
11.85 STAT1 IL12RB1 IFNG HLA-DRB1 HLA-A CD4
30
Show member pathways
11.76 HLA-DRB1 HLA-DQA1 CD4
31 11.74 STAT1 HLA-DRB1 CD4
32 11.73 TNF IL12RB1 IFNG CD4 CCR6
33 11.72 TNF IFNG CD4
34 11.7 HLA-DRB1 HLA-DQA1 CD4
35
Show member pathways
11.68 TNF STAT1 IL12RB1 IFNG CD4
36 11.68 HLA-DRB1 HLA-DQA1 HLA-B HLA-A CLEC7A C3
37 11.64 TNF STAT1 IFNG EGF
38
Show member pathways
11.63 TNF IFNG HLA-A
39 11.38 STAT1 IFNG HLA-B
40 11.26 TNF IFNG HLA-DRB1 CD4
41 11.24 IFNG HLA-DRB1 CD4

GO Terms for Histoplasmosis

Cellular components related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.29 TNF SLC17A5 MT-ND2 MICA IL12RB1 HLA-DRB1
2 plasma membrane GO:0005886 10.13 TNF TF SLC17A5 MICA IL12RB1 HLA-DRB1
3 integral component of plasma membrane GO:0005887 10.02 TNF SLC17A5 MICA HLA-DRB1 HLA-DQA1 HLA-B
4 lysosomal membrane GO:0005765 9.8 SLC17A5 HLA-DRB1 HLA-DQA1 EGF ATP6V1A
5 external side of plasma membrane GO:0009897 9.8 TNF MICA IL12RB1 HLA-DRB1 CD4 CCR6
6 clathrin-coated vesicle membrane GO:0030665 9.61 TF EGF CD4
7 MHC class I protein complex GO:0042612 9.46 HLA-B HLA-A
8 ER to Golgi transport vesicle membrane GO:0012507 9.46 HLA-DRB1 HLA-DQA1 HLA-B HLA-A
9 cell surface GO:0009986 9.32 TNF TF MICA HLA-DRB1 HLA-B HLA-A
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DRB1 HLA-DQA1 HLA-B HLA-A

Biological processes related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.09 TNF TF STAT1 HLA-DRB1 EGF CD4
2 viral process GO:0016032 10.02 STAT1 MICA HLA-B HLA-A CFH CD4
3 adaptive immune response GO:0002250 10 IFNG HLA-DRB1 HLA-DQA1 HLA-B HLA-A CD4
4 immune system process GO:0002376 9.97 HLA-DRB1 HLA-DQA1 HLA-B HLA-A CLEC7A CFH
5 regulation of immune response GO:0050776 9.93 MICA HLA-B HLA-A C3
6 T cell receptor signaling pathway GO:0050852 9.87 HLA-DRB1 HLA-DQA1 HLA-A CD4
7 positive regulation of protein phosphorylation GO:0001934 9.85 TNF IFNG HLA-DRB1 CD4 C3
8 type I interferon signaling pathway GO:0060337 9.8 STAT1 HLA-B HLA-A
9 humoral immune response GO:0006959 9.78 TNF IFNG CCR6
10 positive regulation of interleukin-1 beta production GO:0032731 9.77 TNF IFNG CLEC7A
11 positive regulation of protein complex assembly GO:0031334 9.77 TNF IFNG CLEC7A
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 TNF IFNG CLEC7A
13 positive regulation of interferon-gamma production GO:0032729 9.73 TNF IL12RB1 HLA-A CLEC7A
14 positive regulation of viral entry into host cell GO:0046598 9.65 HLA-DRB1 CD4
15 negative regulation of amyloid-beta clearance GO:1900222 9.65 TNF IFNG
16 positive regulation of monocyte differentiation GO:0045657 9.65 HLA-DRB1 CD4
17 macrophage differentiation GO:0030225 9.65 IFNG HLA-DRB1 CD4
18 T cell mediated cytotoxicity GO:0001913 9.64 MICA HLA-A
19 positive regulation of memory T cell differentiation GO:0043382 9.64 IL12RB1 HLA-DRB1
20 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.63 HLA-B HLA-A
21 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.62 HLA-B HLA-A
22 positive regulation of phagocytosis GO:0050766 9.62 TNF IFNG CLEC7A C3
23 positive regulation of killing of cells of other organism GO:0051712 9.58 IFNG CLEC7A
24 protection from natural killer cell mediated cytotoxicity GO:0042270 9.58 HLA-B HLA-A
25 detection of bacterium GO:0016045 9.58 HLA-DRB1 HLA-B HLA-A
26 antigen processing and presentation GO:0019882 9.56 HLA-DRB1 HLA-DQA1 HLA-B HLA-A
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IFNG
28 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 TNF IFNG
29 positive regulation of nitrogen compound metabolic process GO:0051173 9.49 TNF IFNG
30 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 IL12RB1 HLA-DRB1 HLA-B HLA-A
31 interferon-gamma-mediated signaling pathway GO:0060333 9.43 STAT1 IFNG HLA-DRB1 HLA-DQA1 HLA-B HLA-A
32 immune response GO:0006955 9.32 TNF MICA IFNG HLA-DRB1 HLA-DQA1 HLA-B

Molecular functions related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor binding GO:0042608 9.32 HLA-DRB1 HLA-A
2 MHC class II receptor activity GO:0032395 9.26 HLA-DRB1 HLA-DQA1
3 beta-2-microglobulin binding GO:0030881 9.16 MICA HLA-A
4 TAP binding GO:0046977 8.96 HLA-B HLA-A
5 peptide antigen binding GO:0042605 8.92 HLA-DRB1 HLA-DQA1 HLA-B HLA-A

Sources for Histoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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