MCID: HST011
MIFTS: 55

Histoplasmosis

Categories: Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Histoplasmosis

MalaCards integrated aliases for Histoplasmosis:

Name: Histoplasmosis 12 74 58 42 3 43 15 17 71 32
Infection by Histoplasma Capsulatum 71
Reticuloendotheliosis, X-Linked 43
Darling Disease 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1731
ICD9CM 34 115
SNOMED-CT 67 12962009
ICD10 32 B39 B39.9
MESH via Orphanet 44 D006660
ICD10 via Orphanet 33 B39.0 B39.1 B39.2 more
UMLS via Orphanet 72 C0019655 C0153261
Orphanet 58 ORPHA390
UMLS 71 C0019655 C0035288 C0153261

Summaries for Histoplasmosis

MedlinePlus : 42 Histoplasmosis is a disease caused by a fungus (or mold) called Histoplasma. The fungus is common in the eastern and central United States. It grows in soil and material contaminated with bat or bird droppings. You get infected by breathing the fungal spores. You cannot get the infection from someone else. Histoplasmosis is often mild, with no symptoms. If you do get sick, it usually affects your lungs. Symptoms include feeling ill, fever, chest pains, and a dry cough. In severe cases, histoplasmosis spreads to other organs. This is called disseminated disease. It is more common in infants, young children, older adults, and people with immune system problems. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. Mild cases usually get better without treatment. Treatment of severe or chronic cases is with antifungal drugs. Centers for Disease Control and Prevention

MalaCards based summary : Histoplasmosis, also known as infection by histoplasma capsulatum, is related to american histoplasmosis and african histoplasmosis, and has symptoms including fever and pruritus. An important gene associated with Histoplasmosis is IFNG (Interferon Gamma), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Ranibizumab and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A primary systemic mycosis that results in systemic fungal infection, has material basis in Histoplasma capsulatum var capsulatum or has material basis in Histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC : 3 Histoplasmosis is an infection caused by a fungus called Histoplasma. The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings. In the United States, Histoplasma mainly lives in the central and eastern states, especially areas around the Ohio and Mississippi River valleys. The fungus also lives in parts of Central and South America, Africa, Asia, and Australia. People can get histoplasmosis after breathing in the microscopic fungal spores from the air. Although most people who breathe in the spores don't get sick, those who do may have a fever, cough, and fatigue. Many people who get histoplasmosis will get better on their own without medication, but in some people, such as those who have weakened immune systems, the infection can become severe.

Wikipedia : 74 Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum. Symptoms of this infection vary... more...

Related Diseases for Histoplasmosis

Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 865)
# Related Disease Score Top Affiliating Genes
1 american histoplasmosis 34.3 CD40LG CD4
2 african histoplasmosis 33.9 FAM126A CD4
3 multifocal choroiditis 30.8 TNF CFH ARMS2
4 human immunodeficiency virus type 1 30.7 TNF STAT1 IFNG HLA-B HLA-A CD4
5 penicilliosis 30.6 IFNG CLEC7A CD4
6 pulmonary tuberculosis 30.5 TNF IL12RB1 IFNG C3
7 osteomyelitis 30.5 TNF STAT1 IFNG
8 crohn's colitis 30.5 TNF IFNG CCR6
9 cytomegalovirus infection 30.5 TNF HLA-B HLA-A
10 aphthous stomatitis 30.4 TNF IFNG HLA-B HLA-A
11 pars planitis 30.3 HLA-B HLA-A CCR6
12 pericarditis 30.3 TNF IFNG CD40LG CD4
13 paracoccidioidomycosis 30.3 TNF IL12RB1 IFNG CD40LG
14 chromoblastomycosis 30.3 HLA-A CLEC7A CCR6
15 pancytopenia 30.2 IFNG CD8A CD40LG CD4
16 intestinal tuberculosis 30.2 TNF IFNG CD4
17 toxoplasmosis 30.2 TNF STAT1 IFNG HLA-DQA1 CD40LG
18 panophthalmitis 30.1 IFNG CD4
19 urinary tract obstruction 30.1 TNF EGF CCR6
20 diarrhea 30.1 TNF STAT1 IFNG CFH CD40LG C3
21 cutaneous leishmaniasis 30.1 TNF IL17A IFNG
22 acquired immunodeficiency syndrome 30.1 TNFRSF1B TNF IFNG HLA-B CD40LG CD4
23 conjunctivitis 30.1 TNF IFNG HLA-B
24 neuroretinitis 30.1 CD40LG CD4
25 extrapulmonary tuberculosis 30.1 TNF IFNG CD4
26 pyoderma gangrenosum 30.1 TNFRSF1B TNF CCR6
27 purpura 30.0 TNF IFNG CD40LG C3
28 sporotrichosis 30.0 IFNG CLEC7A CD40LG CD4
29 mucormycosis 30.0 IFNG CLEC7A CD4 CCR6
30 endocarditis 30.0 TNFRSF1B TNF IL17A IFNG
31 tenosynovitis 29.9 TNFRSF1B TNF CD40LG
32 appendicitis 29.9 TNF IL17A IFNG
33 myositis 29.9 TNF IL17A IFNG HLA-DQA1 HLA-B
34 thrombocytopenic purpura, autoimmune 29.9 CD40LG CD4 CCR6
35 acute myocarditis 29.9 TNF STAT1 CD4
36 aspergillosis 29.9 TNFRSF1B TNF IFNG CLEC7A CCR6
37 graft-versus-host disease 29.8 TNF IFNG HLA-B HLA-A
38 lymphadenitis 29.8 TNF IL12RB1 IFNG CD4 CCR6
39 cryptococcal meningitis 29.8 IFNG CD8A CD4 CCR6
40 macular degeneration, age-related, 1 29.8 TNF EGF CFH CCR6 C3 ARMS2
41 seborrheic dermatitis 29.7 TNF CD4 CCR6
42 pelvic inflammatory disease 29.7 IFNG HLA-DQA1 CD40LG CD4
43 scleritis 29.7 TNFRSF1B TNF IFNG CCR6
44 uveitis 29.7 TNFRSF1B TNF IL17A IFNG HLA-B HLA-A
45 lepromatous leprosy 29.7 TNF IL12RB1 IFNG
46 colitis 29.7 TNF IL17A IFNG CCR6
47 hemolytic anemia 29.6 TNF IFNG CFH CD40LG C3
48 invasive aspergillosis 29.6 IFNG CLEC7A CD4 CCR6
49 pyoderma 29.6 TNFRSF1B TNF CD40LG CCR6
50 blastomycosis 29.6 TNF IL17A CLEC7A CD40LG CD4 CCR6

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to Histoplasmosis

Symptoms & Phenotypes for Histoplasmosis

UMLS symptoms related to Histoplasmosis:


fever, pruritus

GenomeRNAi Phenotypes related to Histoplasmosis according to GeneCards Suite gene sharing:

26 (show all 33)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-101 10.3 CLEC7A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.3 CLEC7A HLA-A HLA-B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 10.3 HLA-A HLA-B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 10.3 CLEC7A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 10.3 CLEC7A
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 10.3 CLEC7A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 10.3 CLEC7A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 10.3 HLA-A HLA-B
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 10.3 CLEC7A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 10.3 HLA-A HLA-B
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 10.3 HLA-A HLA-B
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.3 CLEC7A
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-205 10.3 CLEC7A
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 10.3 CLEC7A
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 10.3 CLEC7A
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 10.3 HLA-A HLA-B
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 10.3 HLA-A HLA-B
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 10.3 CLEC7A
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.3 CLEC7A
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 10.3 CLEC7A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.8 HLA-DQA1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.8 HLA-A HLA-B
23 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.8 CD4
24 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.8 CD4
25 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.8 CD4
26 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.8 CD4
27 Increased shRNA abundance (Z-score > 2) GR00366-A-193 9.8 HLA-DQA1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.8 CD4
29 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.8 HLA-DQA1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.8 HLA-DQA1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.8 HLA-A HLA-B
32 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.8 HLA-DQA1
33 Reduced mammosphere formation GR00396-S 9.17 C3 CCR6 CLEC7A HLA-DQA1 IL17A STAT1

MGI Mouse Phenotypes related to Histoplasmosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 C3 CCR6 CD4 CD40LG CD8A CFH
2 immune system MP:0005387 10.19 C3 CCR6 CD4 CD40LG CD8A CFH
3 endocrine/exocrine gland MP:0005379 10.18 C3 CD4 CD40LG CD8A EGF FAM126A
4 digestive/alimentary MP:0005381 10.1 C3 CD4 CLEC7A EGF FAM126A IFNG
5 integument MP:0010771 9.85 CD4 CD40LG CD8A EGF IFNG IL12RB1
6 nervous system MP:0003631 9.7 C3 CCR6 CD4 CD40LG CD8A CFH
7 normal MP:0002873 9.32 C3 CCR6 CD4 CD8A CFH EGF

Drugs & Therapeutics for Histoplasmosis

Drugs for Histoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2
Clobetasol Approved, Experimental, Investigational Phase 4 25122-41-2, 25122-46-7 32798 5311051
3
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 5280453 134070
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6 glucocorticoids Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Micronutrients Phase 4
9 Trace Elements Phase 4
10 Vitamins Phase 4
11 Vasoconstrictor Agents Phase 4
12 Nutrients Phase 4
13 Calcium, Dietary Phase 4
14
Calcium Nutraceutical Phase 4 7440-70-2 271
15
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
16
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
17
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
18
Itraconazole Approved, Investigational Phase 2, Phase 3 84625-61-6 55283
19 Antibiotics, Antitubercular Phase 3
20 Pharmaceutical Solutions Phase 3
21 Anti-Infective Agents, Local Phase 3
22 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
23 Anti-Infective Agents Phase 2, Phase 3
24 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
25
Hydroxyitraconazole Phase 2, Phase 3
26 Antifungal Agents Phase 2, Phase 3
27
Everolimus Approved Phase 1, Phase 2 159351-69-6 70789204 6442177
28
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
29
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838
30
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
31
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
32 Antineoplastic Agents, Immunological Phase 1, Phase 2
33 Immunologic Factors Phase 1, Phase 2
34 topoisomerase I inhibitors Phase 1, Phase 2
35 Immunosuppressive Agents Phase 1, Phase 2
36 Amebicides Phase 2
37 Anti-Bacterial Agents Phase 2
38 Liposomal amphotericin B Phase 2
39 Antiparasitic Agents Phase 2
40 Antiprotozoal Agents Phase 2
41
Ketoconazole Approved, Investigational Phase 1 65277-42-1 47576
42
Petrolatum Approved, Investigational Early Phase 1 8009-03-8
43 Anti-HIV Agents
44 Anti-Retroviral Agents
45 Complement Factor H
46 Complement System Proteins
47 interferons
48 Interferon-gamma
49 Autoantibodies

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Pilot Open-Label Clinical Trial to Test Efficacy and Safety of Combination of Clobex® Spray With Excimer Laser Therapy [Photomedex XTRAC ® Velocity] in the Treatment of Generalized Plaque Psoriasis Followed by Maintenance With Topical Vectical® Ointment Completed NCT01012713 Phase 4 Clobex Spray;Vectical Ointment
2 Intravitreal Aflibercept (VEGF Trap-Eye) in Neovascular Age-related Macular Degeneration With Limited Response to Ranibizumab Completed NCT02309281 Phase 4 aflibercept 2mg
3 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
4 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
5 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
6 Safety, Sensitivity and Specificity of Spherule-derived Coccidioidin in Naive Adults, in Adults With a History of Pulmonary Coccidioidomycosis and in Adults With a History of Pulmonary Histoplasmosis Completed NCT00690092 Phase 3
7 A Pharmacokinetic Study of JK1211 in Patients With Systemic Fungal Infection (SFI) and Patients With Febrile Neutropenia (FN) Suspected of Fungal Infection. Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
8 Submacular Surgery Trials (SST) Completed NCT00000150 Phase 3
9 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
10 SUBA-itraconazole Versus Conventional Itraconazole in the Treatment of Endemic Mycoses: a Multi-center, Open-label Comparative Trial Recruiting NCT03572049 Phase 2, Phase 3 SUBA itraconazole;Conventional itraconazole
11 Open-Label Study to Evaluate the Efficacy and Safety of SCY-078 (Ibrexafungerp) in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment (FURI) Recruiting NCT03059992 Phase 3 Ibrexafungerp
12 Ranibizumab vs PDT for Presumed Ocular Histoplasmosis Unknown status NCT00546936 Phase 2 ranibizumab;verteporfin
13 Intravitreal Aflibercept Injection for the Treatment of cHoroidAl Neovascularization seconDary to Presumed ocuLar Histoplasmosis syndromE.(the HANDLE Study) Unknown status NCT01790893 Phase 1, Phase 2 aflibercept
14 Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome Unknown status NCT00955630 Phase 1, Phase 2 ranibizumab;ranibizumab
15 Pilot Study To Determine the Feasibility of Itraconazole for Primary Treatment and Suppression of Relapse of Disseminated Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000975 Phase 2 Itraconazole
16 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
17 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
18 Phase I / Randomized Phase II Study of Second Line Therapy With Irinotecan and Cetuximab With or Without RAD001, an Oral mTOR Inhibitor for Patients With Metastatic Colorectal Cancer: Hoosier Oncology Group GI05-102 Completed NCT00522665 Phase 1, Phase 2 Irinotecan
19 Open Label Phase-II Randomized Trial of Three Liposomal Amphotericin B Regimens as Induction Therapy for Disseminated Histoplasmosis in AIDS Patients Not yet recruiting NCT04059770 Phase 2 single dose of L-AmB;2 doses of L-AmB;2 weeks of L-AmB
20 Treatment of CNV Secondary to Presumed Ocular Histoplasmosis With EYLEA 2.0mg (Intravitreal Aflibercept Injection) Completed NCT01578720 Phase 1 EYLEA (Aflibercept) intravitreal injection
21 Pilot Study to Determine the Feasibility of Itraconazole for Suppression of Relapse of Disseminated Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000992 Phase 1 Itraconazole
22 A Phase I Single-Center, Randomized, Open-label, Single Dose, Crossover Study in Korean Healthy Male Volunteers to Evaluate Pharmacokinetics of Lozanoc and Sporanox Completed NCT02493738 Phase 1 Lozanoc 50mg;Sporanox 100mg
23 Histoplasmosis in the Guiana Shield and the French West Indies: Evaluating Prevalence in HIV + Patients With a Rapid Diagnostic Test Using an ELISA Capture Method for the Detection of Histoplasma Antigens in Blood and Urine. Unknown status NCT01884779
24 Randomized Study Comparing Itraconazole to Placebo in the Prevention of Histoplasmosis in Patients With Human Immunodeficiency Virus Infection Completed NCT00002438 Itraconazole
25 Discontinuation of Antifungal Therapy for Histoplasmosis Following Immunologic Response to Antiretroviral Therapy Completed NCT00006316
26 Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000627 Fluconazole
27 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization: Multicenter Collaborative Study Completed NCT00645697
28 A Pilot Study Investigating Antitumorigenic Potential of Topical Itraconazole in the Treatment of Basal Cell Carcinoma Completed NCT02120677 Early Phase 1 Itraconazole
29 Pulmonary Infections Masquerading as Community-Acquired Pneumonia Completed NCT00304395
30 Study of Pathogen-Specific Immune Responses and General Immune Competence in Opportunistic Infections Completed NCT00005572
31 AIDS-Associated Heart Disease -- Incidence and Etiology Completed NCT00005228
32 Organ Transplant Infection Prevention and Detection Project 1.0; Cohort Study of Transplant Recipients at "Ultra-High" Risk for Invasive Fungal Infections Completed NCT00177801
33 Complement Factor H Haplotypes and Smoking in Age-related Macular Degeneration Completed NCT01115231
34 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642
35 Mycobacterial and Opportunistic Infections in HIV-Negative Patients Associated With Autoantibodies to Interferon-gamma Active, not recruiting NCT00814827
36 Making an Early Diagnosis of Talaromycosis - a Strategy to Reduce Morbidity and Mortality in Advanced HIV Disease in Southeast Asia Not yet recruiting NCT04033120
37 Macugen for Histoplasmosis-An Open-Label, Single-Site, Comparative, Prospective Case Series Terminated NCT00272766 pegaptanib sodium
38 Investigating the Additive Benefit of the Urine Lipoarabinomannan Test to Current TB Diagnostics Among HIV+ Adults in Panama City, Panama Withdrawn NCT02911740
39 Pilot Study of Intravitreal Bevacizumab vs. Combination Therapy for Choroidal Neovascularization Secondary to Causes Other Than Age-related Macular Degeneration Withdrawn NCT01256580 Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Histoplasmosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Fluconazole
Itraconazole
Ketoconazole

Cochrane evidence based reviews: histoplasmosis

Genetic Tests for Histoplasmosis

Anatomical Context for Histoplasmosis

MalaCards organs/tissues related to Histoplasmosis:

40
Testes, Lung, Skin, Bone, Colon, Bone Marrow, Eye

Publications for Histoplasmosis

Articles related to Histoplasmosis:

(show top 50) (show all 5396)
# Title Authors PMID Year
1
Case Report: Histoplasmosis Accompanying Disseminated Tuberculosis in an Immunocompetent Adolescent Boy. 61 42
31769387 2020
2
Perianal Histoplasmosis Presenting as a Mass Suspicious for Malignancy: A Case Report with Review of Gastrointestinal Manifestations of Histoplasmosis. 42 61
31761896 2019
3
Case 16-2020: A 47-Year-Old Woman with Recurrent Melanoma and Pulmonary Nodules. 42
32433841 2020
4
Histoplasma capsulatum-induced extracellular DNA trap release in human neutrophils. 61
32083807 2020
5
A case of disseminated histoplasmosis presenting with facial and laryngeal involvement. 61
31650978 2020
6
Histoplasma capsulatum 100-kilodalton antigen: recombinant production, characterization, and evaluation of its possible application in the diagnosis of histoplasmosis. 61
32377899 2020
7
Urine antigen-negative disseminated histoplasmosis mimicking post-transplant lymphoproliferative disorder. 61
32532906 2020
8
A 8- year Bangladeshi girl with disseminated histoplasmosis, presented as chronic liver disease with portal hypertension: a rare case report. 61
32513141 2020
9
Fungal prostatitis due to endemic mycoses and Cryptococcus: A multicenter case series. 61
32572997 2020
10
IL-22 Promotes IFN-γ-Mediated Immunity against Histoplasma capsulatum Infection. 61
32517114 2020
11
Histoplasmosis presenting with Sweet's syndrome. 61
32035234 2020
12
Disseminated histoplasmosis presenting as bilateral lower extremity paresis. 61
32272261 2020
13
Fever of Unknown Origin in a Renal Transplant Recipient: Lactate Dehydrogenase as an Important Clue to Diagnosis. 61
31050612 2020
14
Histoplasma capsulatum and Mycobacterium avium co-infection in an immunocompromised patient: Case report and literature review. 61
32322474 2020
15
Remodeling of the Histoplasma Capsulatum Membrane Induced by Monoclonal Antibodies. 61
32498228 2020
16
Colonic Infection by Histoplasma capsulatum in a Liver Transplant Patient: A Case Report. 61
32197866 2020
17
Intractable hypercalcemia in a patient with multiple myeloma: An infectious etiology. 61
32500970 2020
18
Disseminated Histoplasmosis and Miliary Tuberculosis Imitating Colon Cancer in Patient with HIV Who Refuses to Antirretroviral Treatment. 61
32385592 2020
19
Current burden of serious fungal infections in Republic of Congo. 61
32181941 2020
20
Improved serodiagnosis of histoplasmosis by use of deglycosylated extracellular released antigens of Histoplasma capsulatum. 61
32534998 2020
21
Unusual cause of hoarse voice: Laryngotracheal histoplasmosis in renal transplant patient. 61
32510794 2020
22
Improving Notifiable Disease Case Reporting Through Electronic Information Exchange-Facilitated Decision Support: A Controlled Before-and-After Trial. 61
32250707 2020
23
Chronic Pulmonary Histoplasmosis-A Scoping Literature Review. 61
32411810 2020
24
Disseminated Histoplasmosis Diagnosed by "Touch Prep". 61
32472769 2020
25
[Pulmonary histoplasmosis in an immunocompetent patient]. 61
32409000 2020
26
Difficult to Diagnose: An Unusual Cause of Cavitary Lung Lesion. 61
32449900 2020
27
Granulomatous Inflammation Presenting as a Pulmonary Artery Mass. 61
31563494 2020
28
Cholestasis and disseminated histoplasmosis in a psoriatic patient on infliximab: case report and review of literature. 61
32384881 2020
29
Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis. 61
32374962 2020
30
Hemophagocytic lymphohistiocytosis (HLH) caused by disseminated histoplasmosis by H. capsulatum var. duboisii in HIV patient: A case report. 61
32446648 2020
31
Bilateral adrenal histoplasmosis presenting as adrenal insufficiency in an immunocompetent host in the Philippines. 61
32404324 2020
32
Disseminated Histoplasmosis: Fighting a neglected killer of patients with advanced HIV disease in Latin America. 61
32407383 2020
33
Disseminated histoplasmosis presenting as pyoderma gangrenosum-like ulcers in an apparently immunocompetent patient: multiple red herrings presenting a diagnostic challenge. 61
32406079 2020
34
African histoplasmosis in a Guinea Bissau patient with HIV-2: Case report and review. 61
31706701 2020
35
HIV patients dying on anti-tuberculosis treatment: are undiagnosed infections still a problem in French Guiana? 61
32276647 2020
36
Disseminated histoplasmosis with duodenal involvement. 61
32345451 2020
37
Treating progressive disseminated histoplasmosis in people living with HIV. 61
32343003 2020
38
A case of gastrointestinal histoplasmosis with esophageal involvement. 61
31486020 2020
39
A Dimorphic Diagnosis of a Pleomorphic Disease: An Unusual Cause of Hypercalcemia. 61
32320694 2020
40
Primary Central Nervous System Infection by Histoplasma in an Immunocompetent Adult. 61
31989393 2020
41
Deep fungal infections diagnosed by histology in Uganda: a 70-year retrospective study. 61
32242631 2020
42
The role of bone marrow metagenomics next-generation sequencing to differential diagnosis among visceral leishmaniasis, histoplasmosis, and talaromycosis marneffei. 61
31592568 2020
43
US database study: burden and healthcare resource utilization in adults with systemic endemic mycoses and aspergillosis. 61
32316748 2020
44
Colonic histoplasmosis resembling early colon cancer. 61
31715174 2020
45
Disseminated histoplasmosis in primary Sjögren syndrome: A case report. 61
32337209 2020
46
"Pseudo CNS Sarcoidosis": Histoplasmosis of Brain Mimicking Steroid Refractory Sarcoidosis. 61
32373283 2020
47
Mediastinal Histoplasmosis With Esophageal Perforation Presenting as Recurrent Polymicrobial Empyema and Pericarditis in a Previously Healthy Child. 61
31192366 2020
48
Cytological diagnosis of primary cutaneous histoplasmosis with hemophagocytosis in immunocompetent patient - A rare case from non endemic region. 61
32317542 2020
49
Histoplasmosis in HIV-Infected Patients: Epidemiological, Clinical and Necropsy Data from a Brazilian Teaching Hospital. 61
32078723 2020
50
Clinical features and endemic trend of histoplasmosis in China: A retrospective analysis and literature review. 61
31811751 2020

Variations for Histoplasmosis

Expression for Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for Histoplasmosis

Pathways related to Histoplasmosis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 TNFRSF1B TNF STAT1 IL17A IL12RB1 EGF
2
Show member pathways
13.54 TNFRSF1B TNF STAT1 IL17A IL12RB1 IFNG
3
Show member pathways
13.5 TNFRSF1B TNF STAT1 IL17A IL12RB1 IFNG
4
Show member pathways
13.47 HLA-DQA1 HLA-B HLA-A EGF CD8A CD40LG
5
Show member pathways
13.43 TNFRSF1B TNF STAT1 IL17A IL12RB1 EGF
6
Show member pathways
13.31 TNFRSF1B TNF IL17A IL12RB1 EGF CD40LG
7
Show member pathways
13.14 TNFRSF1B TNF STAT1 IL17A IL12RB1 IFNG
8
Show member pathways
13.01 TNF STAT1 HLA-B HLA-A EGF ATP6V1A
9
Show member pathways
12.96 TNFRSF1B TNF STAT1 HLA-B HLA-A CD4
10
Show member pathways
12.83 TNF STAT1 IFNG HLA-DQA1 HLA-B HLA-A
11 12.81 TNF STAT1 IFNG HLA-DQA1 HLA-B HLA-A
12
Show member pathways
12.68 TNFRSF1B TNF STAT1 IFNG EGF CD40LG
13
Show member pathways
12.67 TNFRSF1B TNF IL12RB1 IFNG HLA-DQA1 CD40LG
14
Show member pathways
12.61 TNF STAT1 IL17A IL12RB1 IFNG CD4
15
Show member pathways
12.59 TNF STAT1 IL17A IL12RB1 IFNG HLA-DQA1
16
Show member pathways
12.56 STAT1 IFNG HLA-DQA1 HLA-B HLA-A
17 12.54 TNFRSF1B TNF STAT1 IL17A IFNG CD8A
18
Show member pathways
12.47 TNF STAT1 IL17A IFNG EGF CD8A
19 12.37 TNF HLA-DQA1 HLA-B HLA-A CD4
20
Show member pathways
12.3 TNF STAT1 IL17A IFNG HLA-B HLA-A
21
Show member pathways
12.28 TNF STAT1 IFNG HLA-DQA1 CD40LG C3
22 12.23 TNF STAT1 IFNG HLA-DQA1 CLEC7A C3
23 12.2 TNF STAT1 IFNG EGF
24 12.12 HLA-DQA1 HLA-B HLA-A CLEC7A C3 ATP6V1A
25 12.11 HLA-B HLA-A CD8A CD40LG C3
26
Show member pathways
12.11 TNF STAT1 IL17A IFNG HLA-DQA1 HLA-B
27 12.08 HLA-DQA1 HLA-B HLA-A CD8A CD40LG CD4
28 12.02 TNF IFNG CD8A CD4
29 12.01 TNFRSF1B TNF STAT1 IL17A
30 11.93 TNF HLA-DQA1 CD8A CD4
31
Show member pathways
11.93 STAT1 IL12RB1 IFNG HLA-A CD8A CD4
32 11.92 TNF IL17A IFNG HLA-DQA1 ATP6V1A
33
Show member pathways
11.9 STAT1 IL17A IL12RB1 IFNG CD4
34
Show member pathways
11.87 TNF STAT1 IL17A IL12RB1 IFNG CD4
35
Show member pathways
11.8 TNFRSF1B TNF CD40LG
36 11.79 TNF IFNG CD8A CD4
37
Show member pathways
11.76 TNF IFNG CD40LG
38
Show member pathways
11.74 TNFRSF1B TNF CD40LG
39 11.73 HLA-DQA1 CD8A CD4
40
Show member pathways
11.68 TNF IFNG HLA-A CD8A
41
Show member pathways
11.67 TNF IFNG CD40LG
42 11.66 TNF STAT1 IFNG EGF
43 11.6 TNF IL17A IL12RB1 IFNG CD8A CD4
44
Show member pathways
11.57 TNFRSF1B TNF IFNG
45 11.56 TNF IFNG CD40LG
46 11.43 CD8A CD40LG CD4
47 11.42 STAT1 IFNG HLA-B
48
Show member pathways
11.4 TNFRSF1B TNF IFNG
49 11.36 TNFRSF1B IFNG CD40LG
50 11.34 TNF IL17A IFNG

GO Terms for Histoplasmosis

Cellular components related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.03 TNFRSF1B TNF IL12RB1 HLA-DQA1 HLA-B HLA-A
2 integral component of plasma membrane GO:0005887 9.92 TNF HLA-DQA1 HLA-B HLA-A CD8A CD40LG
3 cell surface GO:0009986 9.56 TNF HLA-B HLA-A CLEC7A CD40LG CD4
4 ER to Golgi transport vesicle membrane GO:0012507 9.54 HLA-DQA1 HLA-B HLA-A
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.43 HLA-DQA1 HLA-B HLA-A
6 MHC class I protein complex GO:0042612 9.4 HLA-B HLA-A
7 external side of plasma membrane GO:0009897 9.17 TNF IL17A IL12RB1 CD8A CD40LG CD4

Biological processes related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.01 IFNG HLA-DQA1 HLA-B HLA-A CD8A CD4
2 immune system process GO:0002376 9.97 HLA-DQA1 HLA-B HLA-A CLEC7A CFH CD8A
3 positive regulation of protein phosphorylation GO:0001934 9.95 TNF IFNG CD4 C3
4 inflammatory response GO:0006954 9.93 TNFRSF1B TNF IL17A CLEC7A CD40LG C3
5 regulation of immune response GO:0050776 9.92 HLA-B HLA-A CD8A CD40LG C3
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.88 TNFRSF1B TNF STAT1 CD40LG
7 cytokine-mediated signaling pathway GO:0019221 9.88 TNFRSF1B TNF STAT1 IL17A IL12RB1 CD4
8 type I interferon signaling pathway GO:0060337 9.84 STAT1 HLA-B HLA-A
9 humoral immune response GO:0006959 9.83 TNF IFNG CCR6
10 positive regulation of protein complex assembly GO:0031334 9.82 TNF IFNG CLEC7A
11 T cell activation GO:0042110 9.8 CLEC7A CD8A CD4
12 positive regulation of interferon-gamma production GO:0032729 9.79 TNF IL12RB1 HLA-A
13 extrinsic apoptotic signaling pathway GO:0097191 9.78 TNFRSF1B TNF IFNG
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 TNF IFNG CLEC7A
15 positive regulation of interleukin-6 secretion GO:2000778 9.77 TNF IL17A IFNG
16 positive regulation of T cell mediated cytotoxicity GO:0001916 9.74 IL12RB1 HLA-B HLA-A
17 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.69 TNF IL17A CLEC7A
18 detection of bacterium GO:0016045 9.67 HLA-B HLA-A
19 negative regulation of amyloid-beta clearance GO:1900222 9.67 TNF IFNG
20 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.67 HLA-B HLA-A
21 positive regulation of osteoclast differentiation GO:0045672 9.67 TNF IL17A IFNG
22 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.66 IL17A CLEC7A
23 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.65 HLA-B HLA-A
24 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.65 IL17A IFNG CLEC7A
25 positive regulation of killing of cells of other organism GO:0051712 9.64 IFNG CLEC7A
26 protection from natural killer cell mediated cytotoxicity GO:0042270 9.63 HLA-B HLA-A
27 regulation of immunoglobulin secretion GO:0051023 9.62 TNF CD40LG
28 positive regulation of interleukin-23 production GO:0032747 9.62 IL17A IFNG
29 positive regulation of phagocytosis GO:0050766 9.62 TNF IFNG CLEC7A C3
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 TNFRSF1B TNF IFNG
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IFNG
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.56 TNF IFNG
33 positive regulation of nitrogen compound metabolic process GO:0051173 9.55 TNF IFNG
34 antigen processing and presentation GO:0019882 9.46 HLA-DQA1 HLA-B HLA-A CD8A
35 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.43 TNF IL17A IFNG
36 immune response GO:0006955 9.4 TNFRSF1B TNF IL17A IFNG HLA-DQA1 HLA-B
37 interferon-gamma-mediated signaling pathway GO:0060333 9.35 STAT1 IFNG HLA-DQA1 HLA-B HLA-A

Molecular functions related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 TNF IL17A IFNG CD40LG
2 protein binding GO:0005515 9.6 TNFRSF1B TNF STAT1 IL17A IL12RB1 IFNG
3 peptide antigen binding GO:0042605 9.33 HLA-DQA1 HLA-B HLA-A
4 TAP binding GO:0046977 9.26 HLA-B HLA-A
5 tumor necrosis factor receptor binding GO:0005164 9.13 TNF STAT1 CD40LG

Sources for Histoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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