MCID: HST011
MIFTS: 54

Histoplasmosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Histoplasmosis

MalaCards integrated aliases for Histoplasmosis:

Name: Histoplasmosis 12 76 59 43 3 44 15 73
Infection by Histoplasma Capsulatum 73
Reticuloendotheliosis, X-Linked 44
Darling Disease 59

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1731
ICD10 33 B39 B39.9 B39.4
ICD9CM 35 115 115.9
Orphanet 59 ORPHA390
MESH via Orphanet 45 D006660
UMLS via Orphanet 74 C0019655 C0153261
ICD10 via Orphanet 34 B39.0 B39.1 B39.2 more

Summaries for Histoplasmosis

MedlinePlus : 43 Histoplasmosis is a disease caused by a fungus (or mold) called Histoplasma. The fungus is common in the eastern and central United States. It grows in soil and material contaminated with bat or bird droppings. You get infected by breathing the fungal spores. You cannot get the infection from someone else. Histoplasmosis is often mild, with no symptoms. If you do get sick, it usually affects your lungs. Symptoms include feeling ill, fever, chest pains, and a dry cough. In severe cases, histoplasmosis spreads to other organs. This is called disseminated disease. It is more common in infants, young children, seniors, and people with immune system problems. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, or examining blood, urine, or tissues for signs of the fungus. Mild cases usually get better without treatment. Treatment of severe or chronic cases is with antifungal drugs. Centers for Disease Control and Prevention

MalaCards based summary : Histoplasmosis, also known as infection by histoplasma capsulatum, is related to panuveitis and arthritis, and has symptoms including fever and pruritus. An important gene associated with Histoplasmosis is ATP6V1A (ATPase H+ Transporting V1 Subunit A), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Influenza A. The drugs Ritonavir and Voriconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A primary systemic mycosis that results in systemic fungal infection, has material basis in Histoplasma capsulatum var capsulatum or has material basis in Histoplasma capsulatum var duboisii, transmitted by airborne spores and has symptom nonproductive cough, has symptom headache, has symptom loss of appetite and has symptom muscle pains.

CDC : 3 Histoplasmosis is an infection caused by a fungus called Histoplasma. The fungus lives in the environment, particularly in soil that contains large amounts of bird or bat droppings. In the United States, Histoplasma mainly lives in the central and eastern states, especially areas around the Ohio and Mississippi River valleys. The fungus also lives in parts of Central and South America, Africa, Asia, and Australia.

Wikipedia : 76 Histoplasmosis (also known as \"Cave disease\", \"Darling\'s disease\", \"Ohio valley disease\",... more...

Related Diseases for Histoplasmosis

Diseases related to Histoplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 panuveitis 30.2 HLA-B HLA-DRB1
2 arthritis 29.4 HLA-DRB1 IFNG MICA
3 connective tissue disease 29.2 HLA-DRB1 IFNG MICA
4 inflammatory bowel disease 28.9 HLA-B HLA-DRB1 IFNG STAT1
5 african histoplasmosis 12.4
6 american histoplasmosis 12.3
7 reticuloendotheliosis, x-linked 12.2
8 histoplasmosis pericarditis 12.1
9 histoplasmosis retinitis 12.0
10 histoplasmosis meningitis 12.0
11 blastomycosis 11.3
12 fibrosing mediastinitis 11.2
13 reticuloendotheliosis 11.0
14 rickets 10.9
15 chronic rhinitis 10.9
16 phenytoin or carbamazepine toxicity 10.7 HLA-A HLA-B
17 baylisascariasis 10.7 ATP6V1A IFNG
18 atrial tachyarrhythmia with short pr interval 10.7 HLA-A HLA-B
19 glaucomatocyclitic crisis 10.7 HLA-A HLA-B
20 cytomegalovirus retinitis 10.7 HLA-B IFNG
21 anterior uveitis 10.7 HLA-A HLA-B
22 intermediate uveitis 10.6 HLA-B IFNG
23 microscopic polyangiitis 10.6 HLA-B HLA-DRB1
24 idiopathic inflammatory myopathy 10.6 HLA-B HLA-DRB1
25 chronic pyelonephritis 10.6 HLA-A HLA-B
26 human herpesvirus 8 10.6 HLA-A HLA-B
27 acute disseminated encephalomyelitis 10.6 HLA-B HLA-DRB1
28 berylliosis 10.6 HLA-DRB1 IFNG
29 chronic beryllium disease 10.6 HLA-DRB1 IFNG
30 progressive bulbar palsy 10.6 HLA-A TF
31 eosinophilia-myalgia syndrome 10.6 HLA-DRB1 IFNG
32 eales disease 10.6 IFNG TF
33 microscopic colitis 10.5 HLA-DRB1 IFNG
34 campylobacteriosis 10.5 IFNG STAT1
35 separation anxiety disorder 10.5 HLA-A HLA-B
36 aphthous stomatitis 10.5 HLA-A HLA-B
37 peanut allergy 10.5 HLA-DRB1 IFNG
38 human t-cell leukemia virus type 2 10.5 IFNG STAT1
39 hemorrhagic fever 10.5 HLA-DRB1 IFNG
40 chronic inflammatory demyelinating polyradiculoneuropathy 10.5 IFNG STAT1
41 chronic graft versus host disease 10.4 IFNG MICA
42 kwashiorkor 10.4 SLC17A5 TF
43 fascioliasis 10.4 IFNG SLC17A5
44 hematopoietic stem cell transplantation 10.3 HLA-A HLA-B IFNG
45 spondyloarthropathy 10.3 HLA-A HLA-B IFNG
46 polyradiculoneuropathy 10.3 IFNG STAT1
47 papillon-lefevre syndrome 10.3 HLA-DRB1 SLC17A5
48 echinococcosis 10.3 HLA-B HLA-DRB1 IFNG
49 vernal conjunctivitis 10.3 IFNG TF
50 palindromic rheumatism 10.3 HLA-A HLA-DRB1

Graphical network of the top 20 diseases related to Histoplasmosis:



Diseases related to Histoplasmosis

Symptoms & Phenotypes for Histoplasmosis

UMLS symptoms related to Histoplasmosis:


fever, pruritus

GenomeRNAi Phenotypes related to Histoplasmosis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.83 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.83 SLC17A5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.83 MICA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.83 HLA-B HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.83 SLC17A5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.83 HLA-B HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.83 MICA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.83 SLC17A5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.83 SLC17A5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.83 SLC17A5
11 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.83 HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.83 HLA-B HLA-A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.83 HLA-B MICA SLC17A5 HLA-A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.83 HLA-B HLA-A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.83 MICA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.83 SLC17A5
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.83 MICA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.83 HLA-B HLA-A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.83 HLA-B HLA-A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.83 SLC17A5
21 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.83 MICA

Drugs & Therapeutics for Histoplasmosis

Drugs for Histoplasmosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
2
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
3
Nevirapine Approved Phase 4 129618-40-2 4463
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
5
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
6
Tenofovir Phase 4 147127-20-6 464205
7
protease inhibitors Phase 4,Phase 3,Not Applicable
8 Reverse Transcriptase Inhibitors Phase 4
9 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
10 Cytochrome P-450 CYP3A Inducers Phase 4
11 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 HIV Protease Inhibitors Phase 4,Phase 3,Not Applicable
13 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
15 Nucleic Acid Synthesis Inhibitors Phase 4
16 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
19 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21 Anti-HIV Agents Phase 4,Phase 3
22 Anti-Retroviral Agents Phase 4,Phase 3
23 Atazanavir Sulfate Phase 4,Phase 3
24 Antiviral Agents Phase 4,Phase 3
25
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
26
Fluconazole Approved, Investigational Phase 3,Phase 2,Not Applicable 86386-73-4 3365
27
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
28
Adalimumab Approved Phase 3 331731-18-1 16219006
29
Itraconazole Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 84625-61-6 55283
30
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
31
Bevacizumab Approved, Investigational Phase 3,Not Applicable 216974-75-3
32
Aldesleukin Approved Phase 3 85898-30-2, 110942-02-4
33 tannic acid Approved, Nutraceutical Phase 3
34 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
35 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1,Not Applicable
36
Hydroxyitraconazole Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Interleukin-2 Phase 3
38 Analgesics Phase 3
39 Analgesics, Non-Narcotic Phase 3
40 Cytochrome P-450 CYP2C9 Inhibitors Phase 3,Phase 2,Not Applicable
41 Peripheral Nervous System Agents Phase 3,Not Applicable
42 Anti-Bacterial Agents Phase 3
43 Antibiotics, Antitubercular Phase 3
44 Pharmaceutical Solutions Phase 3,Early Phase 1
45 Antibodies Phase 3
46 Immunoglobulins Phase 3
47 Antibodies, Monoclonal Phase 3
48 Antiparasitic Agents Phase 3
49 Antiprotozoal Agents Phase 3
50 Anti-Inflammatory Agents Phase 3,Not Applicable

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
2 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
3 Macular Photocoagulation Study (MPS) Unknown status NCT00000158 Phase 3
4 A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis Completed NCT00002159 Phase 3 Itraconazole;Amphotericin B
5 Submacular Surgery Trials (SST) Completed NCT00000150 Phase 3
6 A Multi-center Study of Spherule-Derived Coccidioidin Completed NCT00690092 Phase 3
7 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
8 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
9 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
10 PRINCE: Study of Atazanavir (ATV)/Ritonavir (RTV) Completed NCT01099579 Phase 3 Atazanavir powder;Ritonavir oral solution;Atazanavir capsules;Ritonavir capsules
11 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
12 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
13 Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease Completed NCT00195715 Phase 3
14 Treatment for Presumed Ocular Histoplasmosis Unknown status NCT01790893 Phase 1, Phase 2 aflibercept
15 Ranibizumab Versus PDT for Presumed Ocular Histoplasmosis Unknown status NCT00546936 Phase 2 ranibizumab;verteporfin
16 Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization in Ocular Histoplasmosis Syndrome Unknown status NCT00955630 Phase 1, Phase 2 ranibizumab;ranibizumab
17 A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000975 Phase 2 Itraconazole
18 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
19 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
20 A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000992 Phase 1 Itraconazole
21 A Clinical Study to Evaluate the Pharmacokinetics of Lozanoc and Sporanox in Korean Healthy Male Volunteers Completed NCT02493738 Phase 1 Lozanoc 50mg;Sporanox 100mg
22 Intravitreal Aflibercept Injection (IAI) for Presumed Ocular Histoplasmosis Syndrome Active, not recruiting NCT01578720 Phase 1 EYLEA (Aflibercept) intravitreal injection
23 Withdrawal of Antifungal Treatment for Histoplasmosis in Patients After Improved Immune Response to Anti-HIV Drugs Completed NCT00006316
24 A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients Completed NCT00002438 Not Applicable Itraconazole
25 Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00000627 Not Applicable Fluconazole
26 Intravitreal Bevacizumab in Recalcitrant Inflammatory Ocular Neovascularization Completed NCT00645697
27 A Comparison of HIV-Infected Patients With and Without Opportunistic (AIDS-Related) Infection Completed NCT00005572
28 HIV Cohort Study At Johns Hopkins University, University of North Carolina at Chapel Hill and Vanderbilt University Completed NCT01339416
29 Postmarketing Safety Surveillance European Registry of Crohn's Disease Patients Treated With Remicade or Standard Therapy (MK-2155-035) Completed NCT00705614
30 Kaiser Permanente HIV Cohort Study Completed NCT01339403
31 Observational Safety Study of Etanercept (Enbrel) for Treatment of Psoriasis Completed NCT00322439 Etanercept
32 Topical Itraconazole in the Treatment of Basal Cell Carcinoma Recruiting NCT02120677 Early Phase 1 Itraconazole
33 Prevalence of Histoplasmosis in HIV + Patients With a Rapid Diagnostic Test in West Indies Active, not recruiting NCT01884779
34 Macugen for Histoplasmosis Terminated NCT00272766 Not Applicable pegaptanib sodium
35 Additive Benefit of the Urine LAM Test to Current TB Diagnostics in HIV Positive Adults in Panama City, Panama Withdrawn NCT02911740 Not Applicable
36 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Histoplasmosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: histoplasmosis

Genetic Tests for Histoplasmosis

Anatomical Context for Histoplasmosis

MalaCards organs/tissues related to Histoplasmosis:

41
Lung, Testes, Colon, Skin, Bone, Bone Marrow, Kidney

Publications for Histoplasmosis

Articles related to Histoplasmosis:

(show top 50) (show all 835)
# Title Authors Year
1
Colonic perforation due to GI histoplasmosis in an immunocompetent host mimicking Crohn's disease. ( 29337040 )
2018
2
Disseminated histoplasmosis in an immunocompetent patient - utility of skin scrape cytology in diagnosis: a case report. ( 29325597 )
2018
3
An exuberant form of disseminated histoplasmosis. ( 29936098 )
2018
4
Sepsis-like histoplasmosis in a kidney transplant patient. ( 29738029 )
2018
5
Not Your Typical Arizona Granuloma: A Case Report of Disseminated Histoplasmosis. ( 29730356 )
2018
6
Clinical outcomes and risk factors for death from disseminated histoplasmosis in patients with AIDS who visited a high-complexity hospital in Campo Grande, MS, Brazil. ( 29768547 )
2018
7
Fibrosing Mediastinitis: Uncommon Life-threatening Complication of Histoplasmosis. ( 29946500 )
2018
8
Histoplasmosis in Africa: An emerging or a neglected disease? ( 29346384 )
2018
9
Central nervous system histoplasmosis: Multicenter retrospective study on clinical features, diagnostic approach and outcome of treatment: Erratum. ( 29668643 )
2018
10
Sepsis-like histoplasmosis in a kidney transplant patient. ( 29796577 )
2018
11
Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. ( 29319442 )
2018
12
Adrenal Histoplasmosis. ( 29762233 )
2018
13
Ileum Histoplasmosis Mimicking Intestinal Tuberculosis and Crohn's Disease. ( 29515346 )
2018
14
Disseminated histoplasmosis mimicking relapsed chronic lymphocytic leukaemia. ( 29954761 )
2018
15
Chronic Pulmonary Histoplasmosis Identified in a Young Patient with Selective Immunoglobulin M Deficiency. ( 29888016 )
2018
16
Prior subclinical histoplasmosis revealed in Nigeria using histoplasmin skin testing. ( 29742119 )
2018
17
The important role of co-infections in patients with AIDS and progressive disseminated histoplasmosis (PDH): A cohort from Colombia. ( 29379705 )
2018
18
Unexpected disseminated histoplasmosis detected by bone marrow biopsy in a solid organ transplant patient. ( 29375836 )
2018
19
Gastrointestinal histoplasmosis ileal stricture successfully treated with through-the-scope balloon dilation in a patient with hyperimmunoglobulin M syndrome. ( 29340926 )
2018
20
Oropharyngeal histoplasmosis: The diagnosis lies in the biopsy. ( 29276680 )
2018
21
PRN Ranibizumab in the Treatment of Choroidal Neovascularization Secondary to Ocular Histoplasmosis. ( 29304262 )
2018
22
Diagnosis and treatment of histoplasmosis in solid organ transplant patients. ( 29738315 )
2018
23
Concurrent<i>Pneumocystis jirovecii</i>and pulmonary histoplasmosis in an undiagnosed HIV patient. ( 29374650 )
2018
24
Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis in the setting of Acquired Immunodeficiency Syndrome (AIDS). ( 29657917 )
2018
25
Cave diving for a diagnosis: Disseminated histoplasmosis in the immunocompromised. ( 29942759 )
2018
26
Unilateral adrenal histoplasmosis. ( 29888193 )
2018
27
Hemophagocytic lymphohistiocytosis in an HIV-positive patient with concomitant disseminated histoplasmosis. ( 29433397 )
2018
28
Out of town guest: A healthy 7 year old from a non-endemic area presents with histoplasmosis granulomatous disease. ( 29942767 )
2018
29
Disseminated Histoplasmosis Diagnosed on Bone Marrow Aspiration in a Case of Fever with Thrombocytopenia. ( 29910573 )
2018
30
Histoplasmosis: An oral malignancy-like clinical picture. ( 29379706 )
2018
31
Histoplasmosis in non-endemic North-Western part of India. ( 29735828 )
2018
32
Progressive disseminated histoplasmosis in an immunocompetent adult: A case report. ( 29862155 )
2018
33
Miliary Histoplasmosis in a Patient with Rheumatoid Arthritis. ( 29849657 )
2018
34
Epidemiology and Geographic Distribution of Blastomycosis, Histoplasmosis, and Coccidioidomycosis, Ontario, Canada, 1990-2015. ( 29912691 )
2018
35
Disseminated histoplasmosis in a patient with common variable immunodeficiency: A coincidence or the result of T cell defects? ( 29085780 )
2017
36
INTESTINAL HISTOPLASMOSIS IN A CAPTIVE REINDEER (RANGIFER TARANDUS), MISSOURI, USA. ( 28920817 )
2017
37
Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in systemic lupus erythematosus. ( 28786081 )
2017
38
Histoplasmosis presenting as laryngeal ulcer in a post-renal transplant male: An unusual case from India. ( 28736209 )
2017
39
Demonstrating Hickam's Dictum: Metachronous Pulmonary Adenocarcinoma, Carcinoid Tumor, and Histoplasmosis. ( 28690073 )
2017
40
Peripheral T-Cell Lymphoma in Mediastinum Lymph Nodes and Lung Associated to Histoplasmosis in a Patient with Chronic Lymphoid Leukemia/Small Lymphocytic Lymphoma. ( 28698787 )
2017
41
Candidate prognostic indicators in cats with histoplasmosis treated with antifungal therapy. ( 29256743 )
2017
42
Acute Kidney Injury, Immune Thrombocytopenic Purpura, and the Infection That Binds Them Together: Disseminated Histoplasmosis. ( 29276711 )
2017
43
Correlation of CD4 counts with clinical and histopathological findings in disseminated histoplasmosis: a 10-year retrospective study. ( 28677260 )
2017
44
Role of Transbronchial Needle Aspiration (Conventional and EBUS Guided) in the Diagnosis of Histoplasmosis in Patients Presenting with Mediastinal Lymphadenopathy. ( 28052172 )
2017
45
Concomitant disseminated histoplasmosis and disseminated tuberculosis after tumor necrosis factor inhibitor treatment: a case report. ( 28086756 )
2017
46
Feline cutaneous histoplasmosis: The first case report from Thailand. ( 28794961 )
2017
47
Standardization and validation of real time PCR assays for the diagnosis of histoplasmosis using three molecular targets in an animal model. ( 29287097 )
2017
48
Subdural Empyema in Disseminated Histoplasmosis. ( 29184348 )
2017
49
Tonsillar ulceration as manifestation of disseminated African histoplasmosis in an immunocompetent Portuguese host. ( 28626627 )
2017
50
Disseminated histoplasmosis presenting as multiple oral ulcers. ( 28710196 )
2017

Variations for Histoplasmosis

Expression for Histoplasmosis

Search GEO for disease gene expression data for Histoplasmosis.

Pathways for Histoplasmosis

Pathways related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 HLA-A HLA-B HLA-DRB1 IFNG STAT1
2
Show member pathways
12.45 HLA-A HLA-B HLA-DRB1 IFNG STAT1
3
Show member pathways
12.35 HLA-A HLA-B IFNG STAT1
4
Show member pathways
12.31 HLA-A HLA-B MICA STAT1
5
Show member pathways
12.21 HLA-A HLA-B IFNG MICA
6
Show member pathways
12.2 HLA-DRB1 IFNG STAT1
7 12.17 HLA-A HLA-B HLA-DRB1
8
Show member pathways
12.01 HLA-DRB1 IFNG STAT1
9 12.01 HLA-A HLA-B HLA-DRB1 IFNG
10 11.98 HLA-DRB1 IFNG STAT1
11 11.86 HLA-A HLA-B HLA-DRB1
12
Show member pathways
11.85 HLA-A HLA-B HLA-DRB1 IFNG STAT1
13
Show member pathways
11.84 HLA-A HLA-B HLA-DRB1 IFNG MICA STAT1
14 11.82 HLA-A HLA-B MICA
15 11.74 ATP6V1A HLA-A HLA-B HLA-DRB1
16 11.61 ATP6V1A HLA-DRB1 IFNG
17
Show member pathways
11.51 HLA-A HLA-DRB1 IFNG STAT1
18 11.07 HLA-B IFNG STAT1
19 11.05 HLA-DRB1 IFNG
20 11.01 HLA-DRB1 IFNG
21 10.93 HLA-A HLA-B

GO Terms for Histoplasmosis

Cellular components related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 HLA-A HLA-B HLA-DRB1 MICA TF
2 MHC class I protein complex GO:0042612 9.26 HLA-A HLA-B
3 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-A HLA-B HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-A HLA-B HLA-DRB1

Biological processes related to Histoplasmosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 HLA-A HLA-B HLA-DRB1 IFNG
2 regulation of immune response GO:0050776 9.67 HLA-A HLA-B MICA
3 defense response to virus GO:0051607 9.63 IFNG MICA STAT1
4 retina homeostasis GO:0001895 9.52 ARMS2 TF
5 transferrin transport GO:0033572 9.51 ATP6V1A TF
6 type I interferon signaling pathway GO:0060337 9.5 HLA-A HLA-B STAT1
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.48 HLA-A HLA-B
8 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.4 IFNG STAT1
9 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.37 HLA-A HLA-B
10 viral process GO:0016032 9.35 HLA-A HLA-B HLA-DRB1 MICA STAT1
11 antigen processing and presentation GO:0019882 9.33 HLA-A HLA-B HLA-DRB1
12 protection from natural killer cell mediated cytotoxicity GO:0042270 9.26 HLA-A HLA-B
13 interferon-gamma-mediated signaling pathway GO:0060333 9.02 HLA-A HLA-B HLA-DRB1 IFNG STAT1

Molecular functions related to Histoplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-2-microglobulin binding GO:0030881 8.96 HLA-A MICA
2 peptide antigen binding GO:0042605 8.8 HLA-A HLA-B HLA-DRB1

Sources for Histoplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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