MCID: HBN001
MIFTS: 27

Hobnail Hemangioma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Hobnail Hemangioma

MalaCards integrated aliases for Hobnail Hemangioma:

Name: Hobnail Hemangioma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:505
UMLS 71 C0346076

Summaries for Hobnail Hemangioma

MalaCards based summary : Hobnail Hemangioma is related to hemangioendothelioma and hemangioma. An important gene associated with Hobnail Hemangioma is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Angiogenesis (CST) and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. Affiliated tissues include breast, heart and skin, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Hobnail Hemangioma

Diseases related to Hobnail Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 30.8 FLT4 FLI1 CD34
2 hemangioma 30.5 PECAM1 PDPN FLT4 FLI1 CD34
3 lymphangioma 30.3 PECAM1 PDPN FLT4 CD34
4 histiocytoma 30.3 PECAM1 MYOG CD34
5 capillary lymphangioma 30.1 PECAM1 PDPN FLT4 CD34
6 wilms tumor 1 30.0 WT1 TP63 MYOG CD34
7 angiosarcoma 29.1 PECAM1 PDPN MYOG FLT4 FLI1 CD34
8 vascular cancer 28.9 PECAM1 PDPN MYOG FLT4 FLI1 CD34
9 kaposi sarcoma 10.5
10 skin epithelioid hemangioma 10.4 PECAM1 CD34
11 prostate angiosarcoma 10.4 PECAM1 CD34
12 central nervous system angiosarcoma 10.4 PECAM1 CD34
13 intravascular angioleiomyoma 10.4 PECAM1 CD34
14 heart fibrosarcoma 10.4 PECAM1 CD34
15 central nervous system hemangioma 10.4 PECAM1 CD34
16 ovarian angiosarcoma 10.4 PECAM1 CD34
17 conventional angiosarcoma 10.4 PECAM1 CD34
18 angiomyoma 10.4 PECAM1 CD34
19 retiform hemangioendothelioma 10.4
20 aortic malignant tumor 10.4 PECAM1 CD34
21 gallbladder leiomyosarcoma 10.4 PECAM1 CD34
22 hemangioma of spleen 10.4 PECAM1 CD34
23 ovary sarcoma 10.4 PECAM1 CD34
24 heart leiomyosarcoma 10.4 PECAM1 CD34
25 colonic lymphangioma 10.4 PECAM1 CD34
26 benign perivascular tumor 10.4 PECAM1 CD34
27 intravascular fasciitis 10.4 PECAM1 CD34
28 retroperitoneal hemangiopericytoma 10.4 PECAM1 CD34
29 erythema elevatum diutinum 10.4 PECAM1 CD34
30 liver leiomyoma 10.4 PECAM1 CD34
31 spleen cancer 10.4 PECAM1 CD34
32 vulvar leiomyoma 10.4 PECAM1 CD34
33 nephrogenic adenofibroma 10.4 WT1 CD34
34 glomeruloid hemangioma 10.4 PECAM1 CD34
35 spermatic cord cancer 10.4 WT1 CD34
36 skin sarcoma 10.4 PECAM1 CD34
37 bacillary angiomatosis 10.4 PECAM1 CD34
38 histiocytoid hemangioma 10.4 PECAM1 CD34
39 angiolipoma 10.4 PECAM1 CD34
40 benign mesenchymoma 10.4 PECAM1 CD34
41 glomangioma 10.4 PECAM1 CD34
42 pulmonary artery leiomyosarcoma 10.4 PECAM1 CD34
43 liver leiomyosarcoma 10.4 WT1 CD34
44 acquired hemangioma 10.4 PECAM1 PDPN
45 adenoid squamous cell carcinoma 10.4 PECAM1 CD34
46 subungual glomus tumor 10.4 PECAM1 CD34
47 glomangiomatosis 10.4 PECAM1 CD34
48 bartonellosis 10.4 PECAM1 CD34
49 orbital lymphangioma 10.3 PDPN FLT4
50 angiokeratoma of fordyce 10.3 WT1 PECAM1

Graphical network of the top 20 diseases related to Hobnail Hemangioma:



Diseases related to Hobnail Hemangioma

Symptoms & Phenotypes for Hobnail Hemangioma

MGI Mouse Phenotypes related to Hobnail Hemangioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ACTB FLI1 FLT4 PDPN PECAM1 PIP
2 hematopoietic system MP:0005397 9.97 ACTB CD34 F8 FLI1 PDPN PECAM1
3 homeostasis/metabolism MP:0005376 9.97 ACTB CD34 F8 FLT4 MYOG PDPN
4 immune system MP:0005387 9.96 ACTB CD34 F8 FLI1 FLT4 PDPN
5 embryo MP:0005380 9.88 ACTB FLI1 FLT4 MYOG TP63 WT1
6 muscle MP:0005369 9.76 ACTB FLI1 FLT4 MYOG PDPN PECAM1
7 neoplasm MP:0002006 9.35 ACTB CD34 FLI1 TP63 WT1
8 no phenotypic analysis MP:0003012 9.02 ACTB FLT4 MYOG TP63 WT1

Drugs & Therapeutics for Hobnail Hemangioma

Search Clinical Trials , NIH Clinical Center for Hobnail Hemangioma

Genetic Tests for Hobnail Hemangioma

Anatomical Context for Hobnail Hemangioma

MalaCards organs/tissues related to Hobnail Hemangioma:

40
Breast, Heart, Skin, Liver, Spleen, Prostate, Bone

Publications for Hobnail Hemangioma

Articles related to Hobnail Hemangioma:

(show all 28)
# Title Authors PMID Year
1
Orbital Hobnail Hemangioma. 61
29494379 2018
2
Hobnail Hemangioma With an Unusual Clinical Presentation. 61
27708135 2017
3
Arborizing vessels in a targetoid hemosiderotic hemangioma: mistaken dermoscopic diagnosis of basal cell carcinoma. 61
28243494 2017
4
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions. 61
27318413 2016
5
Hobnail Hemangioma (Superficial Hemosiderotic Lymphovascular Malformation) in Children: A Series of 6 Pediatric Cases and Review of the Literature. 61
26475078 2016
6
Hobnail Hemangioma: A Case Report. 61
26156669 2015
7
Targetoid hemosiderotic hemangioma - Case report. 61
25387500 2014
8
Superficial hemosiderotic lymphovascular malformation (hobnail hemangioma): a report of six cases. 61
24601986 2014
9
Oral hobnail hemangioma: a case report. 61
23808782 2013
10
Hobnail hemangioma on the trunk. 61
24011279 2013
11
Targetoid hemosiderotic hemangioma (Hobnail Hemangioma): typical clinical and histological presentation. 61
24033978 2013
12
Hobnail hemangioma: a immunohistochemical study and literature review. 61
23161236 2012
13
Hobnail hemangioma. 61
22864784 2012
14
A cutaneous vascular neoplasm with hobnail microscopic morphology and unusual gross features. 61
22097956 2012
15
Targetoid hemosiderotic hemangiomas (hobnail hemangiomas) are vascular lymphatic malformations: a study of 12 pediatric cases. 61
21798621 2012
16
Hobnail hemangioma reclassified as superficial lymphatic malformation: a study of 52 cases. 61
21821311 2012
17
Congenital and multiple hobnail hemangiomas. 61
22148030 2011
18
Hobnail hemangioma in a nine-year-old boy: a rare case presented with dermoscopy. 61
20409414 2010
19
Oral hobnail hemangioma: case report. 61
20027132 2009
20
Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma. 61
19606014 2009
21
Oral hobnail hemangioma--a case report. 61
19057748 2008
22
Clinical changes in "true" hobnail hemangioma during menstruation. 61
18517139 2008
23
Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. 61
15059220 2004
24
Immunostaining for human herpesvirus 8 latent nuclear antigen-1 helps distinguish Kaposi sarcoma from its mimickers. 61
15023037 2004
25
Absence of HHV-8 DNA in hobnail hemangiomas. 61
11972712 2002
26
Hobnail hemangioma ("targetoid hemosiderotic hemangioma"): clinicopathologic and immunohistochemical analysis of 62 cases. 61
10472756 1999
27
Hobnail hemangioma: a pseudomalignant vascular lesion with a reappraisal of targetoid hemosiderotic hemangioma. 61
9888709 1999
28
Hobnail hemangioma. 61
8520065 1995

Variations for Hobnail Hemangioma

Expression for Hobnail Hemangioma

Search GEO for disease gene expression data for Hobnail Hemangioma.

Pathways for Hobnail Hemangioma

Pathways related to Hobnail Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 PECAM1 PDPN FLT4
2 10.56 PECAM1 ACTB

GO Terms for Hobnail Hemangioma

Biological processes related to Hobnail Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.56 WT1 TP63 MYOG FLI1
2 retina homeostasis GO:0001895 9.32 PIP ACTB
3 cell motility GO:0048870 9.16 CD34 ACTB
4 lymphangiogenesis GO:0001946 8.96 PDPN FLT4
5 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Hobnail Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.92 WT1 TP63 MYOG FLI1

Sources for Hobnail Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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