MCID: HBN001
MIFTS: 27

Hobnail Hemangioma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Hobnail Hemangioma

MalaCards integrated aliases for Hobnail Hemangioma:

Name: Hobnail Hemangioma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:505
UMLS 71 C0346076

Summaries for Hobnail Hemangioma

MalaCards based summary : Hobnail Hemangioma is related to hemangioendothelioma and hemangioma. An important gene associated with Hobnail Hemangioma is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Angiogenesis (CST) and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. Affiliated tissues include breast, heart and skin, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Hobnail Hemangioma

Diseases related to Hobnail Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 140, show less)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 30.8 FLT4 FLI1 CD34
2 hemangioma 30.5 PECAM1 PDPN FLT4 FLI1 CD34
3 lymphangioma 30.3 PECAM1 PDPN FLT4 CD34
4 histiocytoma 30.3 PECAM1 MYOG CD34
5 capillary lymphangioma 30.1 PECAM1 PDPN FLT4 CD34
6 wilms tumor 1 30.0 WT1 TP63 MYOG CD34
7 angiosarcoma 29.1 PECAM1 PDPN MYOG FLT4 FLI1 CD34
8 vascular cancer 28.9 PECAM1 PDPN MYOG FLT4 FLI1 CD34
9 kaposi sarcoma 10.5
10 skin epithelioid hemangioma 10.4 PECAM1 CD34
11 prostate angiosarcoma 10.4 PECAM1 CD34
12 central nervous system angiosarcoma 10.4 PECAM1 CD34
13 intravascular angioleiomyoma 10.4 PECAM1 CD34
14 heart fibrosarcoma 10.4 PECAM1 CD34
15 central nervous system hemangioma 10.4 PECAM1 CD34
16 ovarian angiosarcoma 10.4 PECAM1 CD34
17 conventional angiosarcoma 10.4 PECAM1 CD34
18 angiomyoma 10.4 PECAM1 CD34
19 retiform hemangioendothelioma 10.4
20 aortic malignant tumor 10.4 PECAM1 CD34
21 gallbladder leiomyosarcoma 10.4 PECAM1 CD34
22 hemangioma of spleen 10.4 PECAM1 CD34
23 ovary sarcoma 10.4 PECAM1 CD34
24 heart leiomyosarcoma 10.4 PECAM1 CD34
25 colonic lymphangioma 10.4 PECAM1 CD34
26 benign perivascular tumor 10.4 PECAM1 CD34
27 intravascular fasciitis 10.4 PECAM1 CD34
28 retroperitoneal hemangiopericytoma 10.4 PECAM1 CD34
29 erythema elevatum diutinum 10.4 PECAM1 CD34
30 liver leiomyoma 10.4 PECAM1 CD34
31 spleen cancer 10.4 PECAM1 CD34
32 vulvar leiomyoma 10.4 PECAM1 CD34
33 nephrogenic adenofibroma 10.4 WT1 CD34
34 glomeruloid hemangioma 10.4 PECAM1 CD34
35 spermatic cord cancer 10.4 WT1 CD34
36 skin sarcoma 10.4 PECAM1 CD34
37 bacillary angiomatosis 10.4 PECAM1 CD34
38 histiocytoid hemangioma 10.4 PECAM1 CD34
39 angiolipoma 10.4 PECAM1 CD34
40 benign mesenchymoma 10.4 PECAM1 CD34
41 glomangioma 10.4 PECAM1 CD34
42 pulmonary artery leiomyosarcoma 10.4 PECAM1 CD34
43 liver leiomyosarcoma 10.4 WT1 CD34
44 acquired hemangioma 10.4 PECAM1 PDPN
45 adenoid squamous cell carcinoma 10.4 PECAM1 CD34
46 subungual glomus tumor 10.4 PECAM1 CD34
47 glomangiomatosis 10.4 PECAM1 CD34
48 bartonellosis 10.4 PECAM1 CD34
49 orbital lymphangioma 10.3 PDPN FLT4
50 angiokeratoma of fordyce 10.3 WT1 PECAM1
51 skin hemangioma 10.3 WT1 PECAM1
52 cystic lymphangioma 10.3 PECAM1 CD34
53 epiglottis cancer 10.3 PDPN CD34
54 atypical neurofibroma 10.3 PDPN CD34
55 congenital lymphedema 10.3 PDPN FLT4
56 congenital granular cell tumor 10.3 PDPN CD34
57 hereditary lymphedema ia 10.3 PDPN FLT4
58 dermis tumor 10.3 PECAM1 CD34
59 adult mesoblastic nephroma 10.3 WT1 CD34
60 wilms tumor 5 10.3
61 epithelioid cell synovial sarcoma 10.3 WT1 CD34
62 ovarian mesodermal adenosarcoma 10.2 WT1 MYOG
63 drug-induced lupus erythematosus 10.2 PECAM1 CD34
64 mayer-rokitansky-kuster-hauser syndrome 10.2 WT1 TP63
65 sarcomatoid squamous cell skin carcinoma 10.2 MYOG CD34
66 cervical polyp 10.2 MYOG CD34
67 liver sarcoma 10.2 MYOG CD34
68 angiokeratoma circumscriptum 10.2 WT1 PECAM1 CD34
69 extraosseous osteosarcoma 10.2 MYOG CD34
70 hereditary lymphedema ic 10.2 PDPN FLT4
71 mesenchymoma 10.2 MYOG CD34
72 intussusception 10.2 PECAM1 CD34
73 prostate stromal sarcoma 10.2 MYOG CD34
74 malignant mesenchymoma 10.2 MYOG CD34
75 retroperitoneal sarcoma 10.2 MYOG CD34
76 hydrocele 10.2 PECAM1 FLT4
77 breast angiosarcoma 10.2 PECAM1 FLT4 CD34
78 endobronchial leiomyoma 10.2 MYOG CD34
79 breast sarcoma 10.2 PECAM1 FLT4 CD34
80 vagina sarcoma 10.2 MYOG CD34
81 capillary disease 10.2 PECAM1 FLT4 CD34
82 adult malignant schwannoma 10.2 MYOG CD34
83 sarcomatoid mesothelioma 10.2 WT1 PDPN
84 uterus leiomyosarcoma 10.2 MYOG CD34
85 breast osteosarcoma 10.1 WT1 MYOG
86 hemangioblastoma 10.1 PECAM1 PDPN CD34
87 testicular fibroma 10.1 WT1 PDPN CD34
88 gorham's disease 10.1 PECAM1 PDPN FLT4
89 pediatric fibrosarcoma 10.1 MYOG CD34
90 lymphangitis 10.1 PECAM1 PDPN FLT4
91 human herpesvirus 8 10.1
92 fibrous histiocytoma 10.1
93 exophthalmos 10.1
94 cavernous lymphangioma 10.1
95 rare lymphatic malformation 10.1
96 connective tissue benign neoplasm 10.1 PECAM1 CD34
97 cavernous hemangioma 10.1 TP63 PECAM1 CD34
98 pediatric angiosarcoma 10.1 PECAM1 F8 CD34
99 breast hemangioma 10.1 PECAM1 F8 CD34
100 thyroid angiosarcoma 10.1 PECAM1 F8 CD34
101 pseudosarcomatous fibromatosis 10.1 MYOG CD34
102 liposarcoma of bone 10.1 PECAM1 MYOG CD34
103 heart sarcoma 10.1 PECAM1 MYOG CD34
104 heart cancer 10.1 PECAM1 MYOG CD34
105 mesenchymal cell neoplasm 10.0 PECAM1 MYOG CD34
106 infantile myofibromatosis 10.0 MYOG CD34
107 mixed cell type cancer 10.0 WT1 MYOG CD34
108 synovium cancer 10.0 WT1 MYOG CD34
109 leiomyosarcoma 10.0 WT1 PECAM1 MYOG
110 skeletal muscle cancer 10.0 WT1 MYOG CD34
111 peritoneal serous papillary adenocarcinoma 10.0 WT1 PIP
112 peritoneal serous adenocarcinoma 10.0 WT1 PIP
113 rhabdoid cancer 10.0 WT1 MYOG
114 spindle cell sarcoma 10.0 MYOG CD34
115 hemangiopericytoma, malignant 10.0 PECAM1 CD34
116 eccrine papillary adenocarcinoma 10.0 PIP PDPN
117 malignant peripheral nerve sheath tumor 9.9 WT1 MYOG CD34
118 capillary hemangioma 9.9 PECAM1 PDPN FLT4 CD34
119 cardiovascular organ benign neoplasm 9.9 PECAM1 PDPN FLT4 CD34
120 x-linked recessive disease 9.9 MYOG F8 CD34
121 sweat gland neoplasm 9.9 PIP CD34
122 benign mesothelioma 9.9 WT1 PECAM1 F8 CD34
123 dacryocystocele 9.9 PIP PDPN
124 chronic inflammation of lacrimal passage 9.9 PIP PDPN
125 vulvar disease 9.9 PIP CD34
126 cribriform carcinoma 9.8 TP63 PIP
127 cystic basal cell carcinoma 9.8 TP63 PIP
128 vulvar benign neoplasm 9.8 PIP PECAM1 CD34
129 blepharocheilodontic syndrome 1 9.8 PIP PDPN
130 kaposiform hemangioendothelioma 9.8 PECAM1 FLT4 FLI1 CD34
131 suppression of tumorigenicity 12 9.7 PECAM1 PDPN ACTB
132 thoracic benign neoplasm 9.7 PIP CD34
133 breast benign neoplasm 9.6 PIP CD34
134 sarcoma, synovial 9.6 WT1 MYOG FLI1 CD34
135 sarcoma 9.6 WT1 MYOG FLT4 FLI1
136 ewing sarcoma 9.6 WT1 MYOG FLI1 CD34
137 lymphangiosarcoma 9.6 PECAM1 PDPN FLT4 F8 CD34
138 signet ring cell adenocarcinoma 9.4 PIP PDPN
139 muscular disease 9.3 WT1 PECAM1 MYOG CD34 ACTB
140 cardiovascular cancer 9.2 PECAM1 PDPN MYOG FLT4 F8 CD34

Graphical network of the top 20 diseases related to Hobnail Hemangioma:



Diseases related to Hobnail Hemangioma

Symptoms & Phenotypes for Hobnail Hemangioma

MGI Mouse Phenotypes related to Hobnail Hemangioma:

45 (showing 8, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ACTB FLI1 FLT4 PDPN PECAM1 PIP
2 hematopoietic system MP:0005397 9.97 ACTB CD34 F8 FLI1 PDPN PECAM1
3 homeostasis/metabolism MP:0005376 9.97 ACTB CD34 F8 FLT4 MYOG PDPN
4 immune system MP:0005387 9.96 ACTB CD34 F8 FLI1 FLT4 PDPN
5 embryo MP:0005380 9.88 ACTB FLI1 FLT4 MYOG TP63 WT1
6 muscle MP:0005369 9.76 ACTB FLI1 FLT4 MYOG PDPN PECAM1
7 neoplasm MP:0002006 9.35 ACTB CD34 FLI1 TP63 WT1
8 no phenotypic analysis MP:0003012 9.02 ACTB FLT4 MYOG TP63 WT1

Drugs & Therapeutics for Hobnail Hemangioma

Search Clinical Trials , NIH Clinical Center for Hobnail Hemangioma

Genetic Tests for Hobnail Hemangioma

Anatomical Context for Hobnail Hemangioma

MalaCards organs/tissues related to Hobnail Hemangioma:

40
Breast, Heart, Skin, Liver, Spleen, Prostate, Bone

Publications for Hobnail Hemangioma

Articles related to Hobnail Hemangioma:

(showing 28, show less)
# Title Authors PMID Year
1
Orbital Hobnail Hemangioma. 61
29494379 2018
2
Hobnail Hemangioma With an Unusual Clinical Presentation. 61
27708135 2017
3
Arborizing vessels in a targetoid hemosiderotic hemangioma: mistaken dermoscopic diagnosis of basal cell carcinoma. 61
28243494 2017
4
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions. 61
27318413 2016
5
Hobnail Hemangioma (Superficial Hemosiderotic Lymphovascular Malformation) in Children: A Series of 6 Pediatric Cases and Review of the Literature. 61
26475078 2016
6
Hobnail Hemangioma: A Case Report. 61
26156669 2015
7
Targetoid hemosiderotic hemangioma - Case report. 61
25387500 2014
8
Superficial hemosiderotic lymphovascular malformation (hobnail hemangioma): a report of six cases. 61
24601986 2014
9
Oral hobnail hemangioma: a case report. 61
23808782 2013
10
Hobnail hemangioma on the trunk. 61
24011279 2013
11
Targetoid hemosiderotic hemangioma (Hobnail Hemangioma): typical clinical and histological presentation. 61
24033978 2013
12
Hobnail hemangioma: a immunohistochemical study and literature review. 61
23161236 2012
13
Hobnail hemangioma. 61
22864784 2012
14
A cutaneous vascular neoplasm with hobnail microscopic morphology and unusual gross features. 61
22097956 2012
15
Targetoid hemosiderotic hemangiomas (hobnail hemangiomas) are vascular lymphatic malformations: a study of 12 pediatric cases. 61
21798621 2012
16
Hobnail hemangioma reclassified as superficial lymphatic malformation: a study of 52 cases. 61
21821311 2012
17
Congenital and multiple hobnail hemangiomas. 61
22148030 2011
18
Hobnail hemangioma in a nine-year-old boy: a rare case presented with dermoscopy. 61
20409414 2010
19
Oral hobnail hemangioma: case report. 61
20027132 2009
20
Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma. 61
19606014 2009
21
Oral hobnail hemangioma--a case report. 61
19057748 2008
22
Clinical changes in "true" hobnail hemangioma during menstruation. 61
18517139 2008
23
Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. 61
15059220 2004
24
Immunostaining for human herpesvirus 8 latent nuclear antigen-1 helps distinguish Kaposi sarcoma from its mimickers. 61
15023037 2004
25
Absence of HHV-8 DNA in hobnail hemangiomas. 61
11972712 2002
26
Hobnail hemangioma ("targetoid hemosiderotic hemangioma"): clinicopathologic and immunohistochemical analysis of 62 cases. 61
10472756 1999
27
Hobnail hemangioma: a pseudomalignant vascular lesion with a reappraisal of targetoid hemosiderotic hemangioma. 61
9888709 1999
28
Hobnail hemangioma. 61
8520065 1995

Variations for Hobnail Hemangioma

Expression for Hobnail Hemangioma

Search GEO for disease gene expression data for Hobnail Hemangioma.

Pathways for Hobnail Hemangioma

Pathways related to Hobnail Hemangioma according to GeneCards Suite gene sharing:

(showing 2, show less)
# Super pathways Score Top Affiliating Genes
1 10.75 PECAM1 PDPN FLT4
2 10.56 PECAM1 ACTB

GO Terms for Hobnail Hemangioma

Biological processes related to Hobnail Hemangioma according to GeneCards Suite gene sharing:

(showing 5, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.56 WT1 TP63 MYOG FLI1
2 retina homeostasis GO:0001895 9.32 PIP ACTB
3 cell motility GO:0048870 9.16 CD34 ACTB
4 lymphangiogenesis GO:0001946 8.96 PDPN FLT4
5 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Hobnail Hemangioma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.92 WT1 TP63 MYOG FLI1

Sources for Hobnail Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....