MCID: HDG003
MIFTS: 27

Hodgkin's Lymphoma, Lymphocytic Depletion

Categories: Cancer diseases, Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Hodgkin's Lymphoma, Lymphocytic Depletion

MalaCards integrated aliases for Hodgkin's Lymphoma, Lymphocytic Depletion:

Name: Hodgkin's Lymphoma, Lymphocytic Depletion 12 15
Hodgkin's Lymphocytic Depletion of Unspecified Site 12
Classic Hodgkin Lymphoma, Lymphocyte-Depleted Type 59
Lymphocyte-Depleted Classical Hodgkin Lymphoma 12
Hodgkin's Disease, Lymphocytic Depletion 12
Hodgkin Lymphoma, Lymphocyte Depletion 12

Characteristics:

Orphanet epidemiological data:

59

Classifications:



External Ids:

Disease Ontology 12 DOID:8628
ICD10 33 C81.3
ICD9CM 35 201.7
MeSH 44 D006689
NCIt 50 C9283
Orphanet 59 ORPHA98846
UMLS via Orphanet 74 C0152267
ICD10 via Orphanet 34 C81.3
UMLS 73 C0152267

Summaries for Hodgkin's Lymphoma, Lymphocytic Depletion

MalaCards based summary : Hodgkin's Lymphoma, Lymphocytic Depletion, also known as hodgkin's lymphocytic depletion of unspecified site, is related to lymphoma, hodgkin, classic and nodular lymphocyte predominant hodgkin lymphoma. An important gene associated with Hodgkin's Lymphoma, Lymphocytic Depletion is POU2AF1 (POU Class 2 Associating Factor 1), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Related phenotypes are hematopoietic system and immune system

Related Diseases for Hodgkin's Lymphoma, Lymphocytic Depletion

Diseases related to Hodgkin's Lymphoma, Lymphocytic Depletion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 lymphoma, hodgkin, classic 30.7 ALK CSF2 PAX5 POU2AF1 PTPRC
2 nodular lymphocyte predominant hodgkin lymphoma 10.6 PAX5 PTPRC
3 primary cutaneous anaplastic large cell lymphoma 10.6 ALK PTPRC
4 hodgkin's granuloma 10.5
5 nodular tenosynovitis 10.4 CD68 PTPRC
6 myeloid sarcoma 10.4 PAX5 PTPRC
7 extracutaneous mastocytoma 10.4 CD68 PTPRC
8 malignant giant cell tumor of soft parts 10.4 CD68 PTPRC
9 glomeruloid hemangioma 10.4 CD68 PTPRC
10 brain sarcoma 10.4 CD68 PTPRC
11 sarcomatoid squamous cell skin carcinoma 10.3 CD68 PTPRC
12 alk+ histiocytosis 10.3 ALK FSCN1
13 photokeratitis 10.3 CD68 PTPRC
14 gamma heavy chain disease 10.2 FUT4 PTPRC
15 malignant fibroxanthoma 10.2 ALK PTPRC
16 xanthogranulomatous pyelonephritis 10.2 ALK CD68
17 adult xanthogranuloma 10.2 CD68 FUT4
18 granulomatous gastritis 10.1 CD68 FUT4
19 malignant leydig cell tumor 10.0 PAX5 TNFRSF8
20 aleukemic leukemia cutis 10.0 CD68 FUT4
21 colloid carcinoma of the pancreas 10.0 FSCN1 FSCN3
22 hemangioma of intra-abdominal structure 10.0 CD68 FUT4
23 adult lymphoma 10.0 ALK TNFRSF8
24 reticulum cell sarcoma 9.9 PTPRC TNFRSF8
25 immune system organ benign neoplasm 9.9 PTPRC TNFRSF8
26 thymus lipoma 9.8 PTPRC TNFRSF8
27 pediatric lymphoma 9.8 ALK TNFRSF8
28 t-cell/histiocyte rich large b cell lymphoma 9.8 CD68 TNFRSF8
29 granulomatous myositis 9.7 CD68 TNFRSF8
30 lichen nitidus 9.7 CD68 TNFRSF8
31 lung lymphoma 9.7 ALK PAX5 TNFRSF8
32 follicular mucinosis 9.7 PTPRC TNFRSF8
33 colon lymphoma 9.7 ALK PTPRC TNFRSF8
34 dendritic cell tumor 9.7 CD68 FSCN1 PTPRC
35 lymphatic system cancer 9.7 ALK PTPRC TNFRSF8
36 ecthyma 9.6 ALK CSF2 TNFRSF8
37 conventional fibrosarcoma 9.4 CD68 PTPRC TNFRSF8
38 testicular infarct 9.4 FUT4 PTPRC TNFRSF8
39 epidural neoplasm 9.4 FUT4 PTPRC TNFRSF8
40 reticulosarcoma 9.3 ALK PAX5 PTPRC TNFRSF8
41 lymphatic system disease 9.3 CD68 TNFRSF8
42 anaplastic large cell lymphoma 9.3 ALK PAX5 PTPRC TNFRSF8
43 sternum cancer 9.2 CD68 FUT4 TNFRSF8
44 leukemia, acute myeloid 9.1 CSF2 FUT4 PTPRC
45 lymphoma 9.1 ALK PAX5 TNFRSF8
46 histiocytosis 8.9 CSF2 FSCN1 PTPRC TNFRSF8
47 lymphoma, non-hodgkin, familial 8.9 ALK CSF2 PAX5 PTPRC TNFRSF8
48 hematologic cancer 8.9 ALK CSF2 PAX5 PTPRC TNFRSF8
49 leber congenital amaurosis 8.8 CD68 FUT4 PTPRC TNFRSF8
50 mediastinal malignant lymphoma 8.2 FSCN1 FSCN3 FUT4 PAX5 TNFRSF8

Graphical network of the top 20 diseases related to Hodgkin's Lymphoma, Lymphocytic Depletion:



Diseases related to Hodgkin's Lymphoma, Lymphocytic Depletion

Symptoms & Phenotypes for Hodgkin's Lymphoma, Lymphocytic Depletion

MGI Mouse Phenotypes related to Hodgkin's Lymphoma, Lymphocytic Depletion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CD68 CSF2 FUT4 PAX5 POU2AF1 PTPRC
2 immune system MP:0005387 9.23 CSF2 FSCN1 FUT4 PAX5 POU2AF1 PTPRC

Drugs & Therapeutics for Hodgkin's Lymphoma, Lymphocytic Depletion

Search Clinical Trials , NIH Clinical Center for Hodgkin's Lymphoma, Lymphocytic Depletion

Genetic Tests for Hodgkin's Lymphoma, Lymphocytic Depletion

Anatomical Context for Hodgkin's Lymphoma, Lymphocytic Depletion

Publications for Hodgkin's Lymphoma, Lymphocytic Depletion

Articles related to Hodgkin's Lymphoma, Lymphocytic Depletion:

# Title Authors Year
1
Lymphocyte-depleted classic Hodgkin lymphoma-a neglected entity? ( 18958495 )
2008

Variations for Hodgkin's Lymphoma, Lymphocytic Depletion

Expression for Hodgkin's Lymphoma, Lymphocytic Depletion

Search GEO for disease gene expression data for Hodgkin's Lymphoma, Lymphocytic Depletion.

Pathways for Hodgkin's Lymphoma, Lymphocytic Depletion

Pathways related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 FSCN1 FUT4 PAX5
2 11.2 CD68 CSF2 PTPRC
3 10.52 PAX5 PTPRC TNFRSF8

GO Terms for Hodgkin's Lymphoma, Lymphocytic Depletion

Cellular components related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 filamentous actin GO:0031941 8.96 FSCN1 FSCN3
2 cell projection membrane GO:0031253 8.62 FSCN1 FSCN3

Biological processes related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.33 ALK CSF2 TNFRSF8
2 establishment or maintenance of cell polarity GO:0007163 9.32 FSCN1 FSCN3
3 actin filament bundle assembly GO:0051017 9.26 FSCN1 FSCN3
4 adult behavior GO:0030534 8.96 ALK PAX5
5 positive regulation of podosome assembly GO:0071803 8.62 CSF2 FSCN1

Sources for Hodgkin's Lymphoma, Lymphocytic Depletion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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