Hodgkin's Lymphoma, Lymphocytic Depletion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hodgkin's Lymphoma, Lymphocytic Depletion

MalaCards integrated aliases for Hodgkin's Lymphoma, Lymphocytic Depletion:

Name: Hodgkin's Lymphoma, Lymphocytic Depletion ¹² ¹⁵

Hodgkin's Lymphocytic Depletion of Unspecified Site ¹²

Classic Hodgkin Lymphoma, Lymphocyte-Depleted Type ⁵⁹

Lymphocyte-Depleted Classical Hodgkin Lymphoma ¹²

Hodgkin's Disease, Lymphocytic Depletion ¹²

Hodgkin Lymphoma, Lymphocyte Depletion ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁹

classic hodgkin lymphoma, lymphocyte-depleted type
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Hodgkin lymphoma

Lymphocyte depleted classical Hodgkin lymphoma

Orphanet: ⁵⁹

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:8628

ICD10 ³³ C81.3

ICD9CM ³⁵ 201.7

MeSH ⁴⁴ D006689

NCIt ⁵⁰ C9283

SNOMED-CT ⁶⁸ 112687003 118610003 134177009 more

Orphanet ⁵⁹ ORPHA98846

UMLS via Orphanet ⁷⁴ C0152267

ICD10 via Orphanet ³⁴ C81.3

UMLS ⁷³ C0152267

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Summaries for Hodgkin's Lymphoma, Lymphocytic Depletion

MalaCards based summary : Hodgkin's Lymphoma, Lymphocytic Depletion, also known as hodgkin's lymphocytic depletion of unspecified site, is related to lymphoma, hodgkin, classic and nodular lymphocyte predominant hodgkin lymphoma. An important gene associated with Hodgkin's Lymphoma, Lymphocytic Depletion is POU2AF1 (POU Class 2 Associating Factor 1), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Related phenotypes are hematopoietic system and immune system

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Related Diseases for Hodgkin's Lymphoma, Lymphocytic Depletion

Diseases related to Hodgkin's Lymphoma, Lymphocytic Depletion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)

#	Related Disease	Score	Top Affiliating Genes
1	lymphoma, hodgkin, classic	30.7	ALK CSF2 PAX5 POU2AF1 PTPRC
2	nodular lymphocyte predominant hodgkin lymphoma	10.6	PAX5 PTPRC
3	primary cutaneous anaplastic large cell lymphoma	10.6	ALK PTPRC
4	hodgkin's granuloma	10.5
5	nodular tenosynovitis	10.4	CD68 PTPRC
6	myeloid sarcoma	10.4	PAX5 PTPRC
7	extracutaneous mastocytoma	10.4	CD68 PTPRC
8	malignant giant cell tumor of soft parts	10.4	CD68 PTPRC
9	glomeruloid hemangioma	10.4	CD68 PTPRC
10	brain sarcoma	10.4	CD68 PTPRC
11	sarcomatoid squamous cell skin carcinoma	10.3	CD68 PTPRC
12	alk+ histiocytosis	10.3	ALK FSCN1
13	photokeratitis	10.3	CD68 PTPRC
14	gamma heavy chain disease	10.2	FUT4 PTPRC
15	malignant fibroxanthoma	10.2	ALK PTPRC
16	xanthogranulomatous pyelonephritis	10.2	ALK CD68
17	adult xanthogranuloma	10.2	CD68 FUT4
18	granulomatous gastritis	10.1	CD68 FUT4
19	malignant leydig cell tumor	10.0	PAX5 TNFRSF8
20	aleukemic leukemia cutis	10.0	CD68 FUT4
21	colloid carcinoma of the pancreas	10.0	FSCN1 FSCN3
22	hemangioma of intra-abdominal structure	10.0	CD68 FUT4
23	adult lymphoma	10.0	ALK TNFRSF8
24	reticulum cell sarcoma	9.9	PTPRC TNFRSF8
25	immune system organ benign neoplasm	9.9	PTPRC TNFRSF8
26	thymus lipoma	9.8	PTPRC TNFRSF8
27	pediatric lymphoma	9.8	ALK TNFRSF8
28	t-cell/histiocyte rich large b cell lymphoma	9.8	CD68 TNFRSF8
29	granulomatous myositis	9.7	CD68 TNFRSF8
30	lichen nitidus	9.7	CD68 TNFRSF8
31	lung lymphoma	9.7	ALK PAX5 TNFRSF8
32	follicular mucinosis	9.7	PTPRC TNFRSF8
33	colon lymphoma	9.7	ALK PTPRC TNFRSF8
34	dendritic cell tumor	9.7	CD68 FSCN1 PTPRC
35	lymphatic system cancer	9.7	ALK PTPRC TNFRSF8
36	ecthyma	9.6	ALK CSF2 TNFRSF8
37	conventional fibrosarcoma	9.4	CD68 PTPRC TNFRSF8
38	testicular infarct	9.4	FUT4 PTPRC TNFRSF8
39	epidural neoplasm	9.4	FUT4 PTPRC TNFRSF8
40	reticulosarcoma	9.3	ALK PAX5 PTPRC TNFRSF8
41	lymphatic system disease	9.3	CD68 TNFRSF8
42	anaplastic large cell lymphoma	9.3	ALK PAX5 PTPRC TNFRSF8
43	sternum cancer	9.2	CD68 FUT4 TNFRSF8
44	leukemia, acute myeloid	9.1	CSF2 FUT4 PTPRC
45	lymphoma	9.1	ALK PAX5 TNFRSF8
46	histiocytosis	8.9	CSF2 FSCN1 PTPRC TNFRSF8
47	lymphoma, non-hodgkin, familial	8.9	ALK CSF2 PAX5 PTPRC TNFRSF8
48	hematologic cancer	8.9	ALK CSF2 PAX5 PTPRC TNFRSF8
49	leber congenital amaurosis	8.8	CD68 FUT4 PTPRC TNFRSF8
50	mediastinal malignant lymphoma	8.2	FSCN1 FSCN3 FUT4 PAX5 TNFRSF8

Graphical network of the top 20 diseases related to Hodgkin's Lymphoma, Lymphocytic Depletion:

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Symptoms & Phenotypes for Hodgkin's Lymphoma, Lymphocytic Depletion

MGI Mouse Phenotypes related to Hodgkin's Lymphoma, Lymphocytic Depletion:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.5	CD68 CSF2 FUT4 PAX5 POU2AF1 PTPRC
2	immune system	MP:0005387	9.23	CSF2 FSCN1 FUT4 PAX5 POU2AF1 PTPRC

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Drugs & Therapeutics for Hodgkin's Lymphoma, Lymphocytic Depletion

Search Clinical Trials , NIH Clinical Center for Hodgkin's Lymphoma, Lymphocytic Depletion

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Genetic Tests for Hodgkin's Lymphoma, Lymphocytic Depletion

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Anatomical Context for Hodgkin's Lymphoma, Lymphocytic Depletion

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Publications for Hodgkin's Lymphoma, Lymphocytic Depletion

Articles related to Hodgkin's Lymphoma, Lymphocytic Depletion:

#	Title	Authors	Year
1	Lymphocyte-depleted classic Hodgkin lymphoma-a neglected entity? ( 18958495 )	Benharroch D....Sacks M.	2008

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Genes for Hodgkin's Lymphoma, Lymphocytic Depletion

Genes related to Hodgkin's Lymphoma, Lymphocytic Depletion (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POU2AF1	POU Class 2 Associating Factor 1	Protein Coding	15.75	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PAX5	Paired Box 5	Protein Coding	15.47	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	13.64	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	13.56	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CSF2	Colony Stimulating Factor 2	Protein Coding	13.26	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	LDHAL6B	Lactate Dehydrogenase A Like 6B	Protein Coding	7.05	DISEASES inferred ¹⁵
7	FSCN3	Fascin Actin-Bundling Protein 3	Protein Coding	5.13	DISEASES inferred ¹⁵
8	FUT4	Fucosyltransferase 4	Protein Coding	5.08	DISEASES inferred ¹⁵
9	FSCN1	Fascin Actin-Bundling Protein 1	Protein Coding	4.73	DISEASES inferred ¹⁵
10	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	4.6	DISEASES inferred ¹⁵
11	CD68	CD68 Molecule	Protein Coding	3.47	DISEASES inferred ¹⁵

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Variations for Hodgkin's Lymphoma, Lymphocytic Depletion

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Expression for Hodgkin's Lymphoma, Lymphocytic Depletion

Search GEO for disease gene expression data for Hodgkin's Lymphoma, Lymphocytic Depletion.

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Pathways for Hodgkin's Lymphoma, Lymphocytic Depletion

Pathways related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Wnt / Hedgehog / Notch ⁴	11.59	FSCN1 FUT4 PAX5
2	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.2	CD68 CSF2 PTPRC
3	B Cell Development Pathways ⁶⁵	10.52	PAX5 PTPRC TNFRSF8

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GO Terms for Hodgkin's Lymphoma, Lymphocytic Depletion

Cellular components related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	filamentous actin	GO:0031941	8.96	FSCN1 FSCN3
2	cell projection membrane	GO:0031253	8.62	FSCN1 FSCN3

Biological processes related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cell proliferation	GO:0042127	9.33	ALK CSF2 TNFRSF8
2	establishment or maintenance of cell polarity	GO:0007163	9.32	FSCN1 FSCN3
3	actin filament bundle assembly	GO:0051017	9.26	FSCN1 FSCN3
4	adult behavior	GO:0030534	8.96	ALK PAX5
5	positive regulation of podosome assembly	GO:0071803	8.62	CSF2 FSCN1

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Sources for Hodgkin's Lymphoma, Lymphocytic Depletion

¹ BioSystems

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia