Hodgkin's Lymphoma, Lymphocytic Depletion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Hodgkin's Lymphoma, Lymphocytic Depletion

MalaCards integrated aliases for Hodgkin's Lymphoma, Lymphocytic Depletion:

Name: Hodgkin's Lymphoma, Lymphocytic Depletion ¹² ¹⁵

Hodgkin's Lymphocytic Depletion of Unspecified Site ¹²

Classic Hodgkin Lymphoma, Lymphocyte-Depleted Type ⁵⁹

Lymphocyte-Depleted Classical Hodgkin Lymphoma ¹²

Hodgkin's Disease, Lymphocytic Depletion ¹²

Hodgkin Lymphoma, Lymphocyte Depletion ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁹

classic hodgkin lymphoma, lymphocyte-depleted type
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Hodgkin lymphoma

Lymphocyte depleted classical Hodgkin lymphoma

Orphanet: ⁵⁹

Rare haematological diseases

External Ids:

Disease Ontology ¹² DOID:8628

ICD10 ³³ C81.3

ICD9CM ³⁵ 201.7

MeSH ⁴⁴ D006689

NCIt ⁵⁰ C9283

Orphanet ⁵⁹ ORPHA98846

UMLS via Orphanet ⁷⁴ C0152267

ICD10 via Orphanet ³⁴ C81.3

UMLS ⁷³ C0152267

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Summaries for Hodgkin's Lymphoma, Lymphocytic Depletion

MalaCards based summary : Hodgkin's Lymphoma, Lymphocytic Depletion, also known as hodgkin's lymphocytic depletion of unspecified site, is related to lymphoma, hodgkin, classic and hodgkin's granuloma. An important gene associated with Hodgkin's Lymphoma, Lymphocytic Depletion is POU2AF1 (POU Class 2 Associating Factor 1), and among its related pathways/superpathways are NF-kappaB Signaling and Wnt / Hedgehog / Notch. Affiliated tissues include lung, brain and colon, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Hodgkin's Lymphoma, Lymphocytic Depletion

Diseases related to Hodgkin's Lymphoma, Lymphocytic Depletion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Related Disease	Score	Top Affiliating Genes
1	lymphoma, hodgkin, classic	31.6	ALK CD79A PAX5 PTPRC
2	hodgkin's granuloma	10.6
3	gray zone lymphoma	10.2	CD79A PAX5
4	bladder lymphoma	10.2	CD79A PAX5
5	primary cutaneous anaplastic large cell lymphoma	10.2	ALK PTPRC
6	small intestine lymphoma	10.1	CD79A PTPRC
7	viral esophagitis	10.1	CD68 CD79A
8	nodular tenosynovitis	10.1	CD68 PTPRC
9	extracutaneous mastocytoma	10.1	CD68 PTPRC
10	malignant giant cell tumor of soft parts	10.1	CD68 PTPRC
11	lymphoplasmacyte-rich meningioma	10.1	CD68 CD79A
12	brain sarcoma	10.1	CD68 PTPRC
13	plasma cell neoplasm	10.1	CD79A PTPRC
14	gamma heavy chain disease	10.1	FUT4 PTPRC
15	myeloid sarcoma	10.1	PAX5 PTPRC
16	glomeruloid hemangioma	10.1	CD68 PTPRC
17	lymphoma	10.1
18	trigeminal nerve neoplasm	10.1	CD68 PTPRC
19	neurilemmoma of the fifth cranial nerve	10.1	CD68 PTPRC
20	lymphosarcoma	10.1	CD79A PTPRC
21	photokeratitis	10.1	CD68 PTPRC
22	alk+ histiocytosis	10.1	ALK FSCN1
23	ulcerative stomatitis	10.1	CD68 CD79A
24	granulomatous gastritis	10.1	CD68 FUT4
25	adult xanthogranuloma	10.1	CD68 FUT4
26	aleukemic leukemia cutis	10.0	CD68 FUT4
27	mature b-cell neoplasm	10.0	CD79A PTPRC
28	malignant leydig cell tumor	10.0	PAX5 TNFRSF8
29	hemangioma of intra-abdominal structure	10.0	CD68 FUT4
30	reticulum cell sarcoma	10.0	PTPRC TNFRSF8
31	colloid carcinoma of the pancreas	10.0	FSCN1 FSCN3
32	melkersson-rosenthal syndrome	10.0	CD68 PTPRC
33	thymus lipoma	10.0	PTPRC TNFRSF8
34	adult lymphoma	10.0	ALK TNFRSF8
35	immune system organ benign neoplasm	9.9	PTPRC TNFRSF8
36	lichen nitidus	9.9	CD68 TNFRSF8
37	t-cell/histiocyte rich large b cell lymphoma	9.9	CD68 TNFRSF8
38	granulomatous myositis	9.9	CD68 TNFRSF8
39	dendritic cell tumor	9.9	CD68 FSCN1 PTPRC
40	pediatric lymphoma	9.9	ALK CD79A TNFRSF8
41	follicular mucinosis	9.9	PTPRC TNFRSF8
42	histiocytosis	9.9	CSF2 PTPRC TNFRSF8
43	ecthyma	9.9	ALK CSF2 TNFRSF8
44	testicular infarct	9.9	FUT4 PTPRC TNFRSF8
45	epidural neoplasm	9.9	FUT4 PTPRC TNFRSF8
46	conventional fibrosarcoma	9.8	CD68 PTPRC TNFRSF8
47	lung lymphoma	9.8	ALK CD79A PAX5 TNFRSF8
48	reticulosarcoma	9.8	ALK PAX5 PTPRC TNFRSF8
49	anaplastic large cell lymphoma	9.8	ALK PAX5 PTPRC TNFRSF8
50	colon lymphoma	9.8	ALK CD79A PTPRC TNFRSF8

Graphical network of the top 20 diseases related to Hodgkin's Lymphoma, Lymphocytic Depletion:

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Symptoms & Phenotypes for Hodgkin's Lymphoma, Lymphocytic Depletion

MGI Mouse Phenotypes related to Hodgkin's Lymphoma, Lymphocytic Depletion:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.76	CD68 CD79A CSF2 FUT4 PAX5 POU2AF1
2	immune system	MP:0005387	9.61	CD68 CD79A CSF2 FSCN1 FUT4 PAX5
3	neoplasm	MP:0002006	9.02	ALK CD79A CSF2 PAX5 PTPRC

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Drugs & Therapeutics for Hodgkin's Lymphoma, Lymphocytic Depletion

Search Clinical Trials , NIH Clinical Center for Hodgkin's Lymphoma, Lymphocytic Depletion

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Genetic Tests for Hodgkin's Lymphoma, Lymphocytic Depletion

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Anatomical Context for Hodgkin's Lymphoma, Lymphocytic Depletion

MalaCards organs/tissues related to Hodgkin's Lymphoma, Lymphocytic Depletion:

⁴¹

Lung, Brain, Colon, Pancreas, B Cells, Thymus, Small Intestine

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Publications for Hodgkin's Lymphoma, Lymphocytic Depletion

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Genes for Hodgkin's Lymphoma, Lymphocytic Depletion

Genes related to Hodgkin's Lymphoma, Lymphocytic Depletion (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POU2AF1	POU Class 2 Associating Factor 1	Protein Coding	15.7	DISEASES inferred ¹⁵
2	PAX5	Paired Box 5	Protein Coding	15.4	DISEASES inferred ¹⁵
3	CD79A	CD79a Molecule	Protein Coding	14.22	DISEASES inferred ¹⁵
4	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	13.48	DISEASES inferred ¹⁵
5	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	13.45	DISEASES inferred ¹⁵
6	CSF2	Colony Stimulating Factor 2	Protein Coding	13.18	DISEASES inferred ¹⁵
7	LDHAL6B	Lactate Dehydrogenase A Like 6B	Protein Coding	7.03	DISEASES inferred ¹⁵
8	FUT4	Fucosyltransferase 4	Protein Coding	5	DISEASES inferred ¹⁵
9	FSCN3	Fascin Actin-Bundling Protein 3	Protein Coding	4.98	DISEASES inferred ¹⁵
10	FSCN1	Fascin Actin-Bundling Protein 1	Protein Coding	4.58	DISEASES inferred ¹⁵
11	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	4.55	DISEASES inferred ¹⁵
12	CD68	CD68 Molecule	Protein Coding	3.38	DISEASES inferred ¹⁵

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Variations for Hodgkin's Lymphoma, Lymphocytic Depletion

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Expression for Hodgkin's Lymphoma, Lymphocytic Depletion

Search GEO for disease gene expression data for Hodgkin's Lymphoma, Lymphocytic Depletion.

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Pathways for Hodgkin's Lymphoma, Lymphocytic Depletion

Pathways related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	11.97	CD79A PAX5 PTPRC TNFRSF8
2	Wnt / Hedgehog / Notch ⁴	11.69	FSCN1 FUT4 PAX5
3	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	10.99	CD68 CD79A CSF2 PTPRC
4	Primary immunodeficiency ³⁷	10.89	CD79A PTPRC
5	B Cell Development Pathways ⁶⁵	10.86	PAX5 PTPRC TNFRSF8

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GO Terms for Hodgkin's Lymphoma, Lymphocytic Depletion

Biological processes related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	actin filament bundle assembly	GO:0051017	9.37	FSCN1 FSCN3
2	establishment or maintenance of cell polarity	GO:0007163	9.32	FSCN1 FSCN3
3	B cell proliferation	GO:0042100	9.26	CD79A PTPRC
4	adult behavior	GO:0030534	9.16	ALK PAX5
5	positive regulation of podosome assembly	GO:0071803	8.96	CSF2 FSCN1
6	regulation of B cell receptor signaling pathway	GO:0050855	8.62	PAX5 PTPRC

Molecular functions related to Hodgkin's Lymphoma, Lymphocytic Depletion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	8.8	ALK CD79A TNFRSF8

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Sources for Hodgkin's Lymphoma, Lymphocytic Depletion

¹ BioSystems

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⁷¹ TGDB

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⁷⁶ Wikipedia