MCID: HDG001
MIFTS: 29

Hodgkin's Lymphoma, Nodular Sclerosis

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Hodgkin's Lymphoma, Nodular Sclerosis

MalaCards integrated aliases for Hodgkin's Lymphoma, Nodular Sclerosis:

Name: Hodgkin's Lymphoma, Nodular Sclerosis 12 15
Classic Hodgkin Lymphoma, Nodular Sclerosis Type 58
Classical Hodgkin Lymphoma, Nodular Sclerosis 12
Hodgkin's Disease, Nodular Sclerosis 70
Nodular Sclerosis Hodgkin Lymphoma 17

Characteristics:

Orphanet epidemiological data:

58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:8838
ICD9CM 34 201.5
NCIt 50 C3518
SNOMED-CT 67 52248008
ICD10 32 C81.1
ICD10 via Orphanet 33 C81.1
UMLS via Orphanet 71 C0152268
Orphanet 58 ORPHA98843
UMLS 70 C0152268

Summaries for Hodgkin's Lymphoma, Nodular Sclerosis

MalaCards based summary : Hodgkin's Lymphoma, Nodular Sclerosis, also known as classic hodgkin lymphoma, nodular sclerosis type, is related to myeloid sarcoma and b-cell lymphoma, and has symptoms including fever and night sweats. An important gene associated with Hodgkin's Lymphoma, Nodular Sclerosis is KLHDC8B (Kelch Domain Containing 8B), and among its related pathways/superpathways are NF-kappaB Signaling and IgA-Producing B Cells in the Intestine. Affiliated tissues include bone marrow, thymus and myeloid, and related phenotypes are hematopoietic system and immune system

Related Diseases for Hodgkin's Lymphoma, Nodular Sclerosis

Diseases related to Hodgkin's Lymphoma, Nodular Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 myeloid sarcoma 30.0 PAX5 CD79A
2 b-cell lymphoma 30.0 TNFRSF8 PAX5 BCL6
3 lymphoma 29.6 TNFRSF8 PAX5 KLHDC8B BCL6
4 lymphoma, hodgkin, classic 29.4 TNFRSF8 PAX5 KLHDC8B KDM4C BCL6
5 diffuse large b-cell lymphoma 29.2 TNFRSF8 PAX5 CD79A BCL6
6 lymphoma, non-hodgkin, familial 28.9 TNFRSF8 PAX5 KDM4C CD79A BCL6
7 rosai-dorfman disease 10.2
8 pleural lipoma 10.2 TNFRSF8 FUT4
9 uterus leiomyosarcoma 10.2 TNFRSF8 FUT4
10 submandibular adenitis 10.1 TNFRSF8 PAX5
11 breast lipoma 10.1 TNFRSF8 PAX5
12 uterine corpus sarcoma 10.1 TNFRSF8 FUT4
13 nasopharyngeal carcinoma 10.1
14 mantle cell lymphoma 10.1
15 sarcoma 10.1
16 central nervous system disease 10.1
17 spindle cell sarcoma 10.1
18 nervous system disease 10.1
19 primary mediastinal large b-cell lymphoma 10.1
20 infected hydrocele 10.0 TNFRSF8 CD79A
21 cerebral lymphoma 10.0 TNFRSF8 CD79A
22 adult acute lymphocytic leukemia 10.0 TNFRSF8 PAX5
23 hematologic cancer 10.0 TNFRSF8 PAX5 KDM4C
24 monoclonal paraproteinemia 10.0 PAX5 CD79A
25 hodgkin's lymphoma, mixed cellularity 9.9 TNFRSF8 FUT4 CT45A1
26 germ cell and embryonal cancer 9.9 KDM4C FUT4
27 t-cell/histiocyte rich large b cell lymphoma 9.9 TNFRSF8 BCL6
28 lymphosarcoma 9.9 TNFRSF8 BCL6
29 adult lymphoma 9.9 TNFRSF8 BCL6
30 nodal marginal zone lymphoma 9.9 KDM4C BCL6
31 orofaciodigital syndrome viii 9.9 KDM4C BCL6
32 primary cutaneous b-cell lymphoma 9.9 PAX5 BCL6
33 primary mediastinal b-cell lymphoma 9.9 KDM4C BCL6
34 primary central nervous system lymphoma 9.8 PAX5 BCL6
35 bladder lymphoma 9.8 CD79A BCL6
36 testicular disease 9.8 TNFRSF8 KDM4C
37 central nervous system lymphoma 9.8 PAX5 BCL6
38 intraocular lymphoma 9.8 PAX5 BCL6
39 multicentric castleman disease 9.8 TNFRSF8 PAX5 CD79A
40 membranoproliferative glomerulonephritis 9.8 FUT4 CD79A
41 epiglottis neoplasm 9.8 CD79A BCL6
42 colon lymphoma 9.8 CD79A BCL6
43 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.8 TNFRSF8 FUT4 BCL6
44 alpha chain disease 9.8 CD79A BCL6
45 angioimmunoblastic t-cell lymphoma 9.8 TNFRSF8 BCL6
46 breast osteosarcoma 9.8 CD79A BCL6
47 splenic marginal zone lymphoma 9.7 PAX5 BCL6
48 tracheal lymphoma 9.7 TNFRSF8 PAX5 BCL6
49 gastric lymphoma 9.7 CD79A BCL6
50 reticulosarcoma 9.7 TNFRSF8 PAX5 BCL6

Graphical network of the top 20 diseases related to Hodgkin's Lymphoma, Nodular Sclerosis:



Diseases related to Hodgkin's Lymphoma, Nodular Sclerosis

Symptoms & Phenotypes for Hodgkin's Lymphoma, Nodular Sclerosis

UMLS symptoms related to Hodgkin's Lymphoma, Nodular Sclerosis:


fever; night sweats

MGI Mouse Phenotypes related to Hodgkin's Lymphoma, Nodular Sclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 BCL6 CD79A FUT4 KDM4C PAX5 RIC1
2 immune system MP:0005387 9.17 BCL6 CD79A FUT4 KDM4C PAX5 RIC1

Drugs & Therapeutics for Hodgkin's Lymphoma, Nodular Sclerosis

Search Clinical Trials , NIH Clinical Center for Hodgkin's Lymphoma, Nodular Sclerosis

Genetic Tests for Hodgkin's Lymphoma, Nodular Sclerosis

Anatomical Context for Hodgkin's Lymphoma, Nodular Sclerosis

MalaCards organs/tissues related to Hodgkin's Lymphoma, Nodular Sclerosis:

40
Bone Marrow, Thymus, Myeloid, Tongue, Neutrophil

Publications for Hodgkin's Lymphoma, Nodular Sclerosis

Articles related to Hodgkin's Lymphoma, Nodular Sclerosis:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Multiple lung lesions in a 13-year-old girl with classical nodular sclerosis Hodgkin Lymphoma. 61
33386595 2021
2
Metastatic nasopharyngeal carcinoma mimicking nodular sclerosis Hodgkin lymphoma. 61
33242332 2020
3
MRI features of primary hepatic lymphoma. 61
29460044 2018
4
Unusual case of primary pulmonary Hodgkin's lymphoma presenting with a continuous murmur. 61
30269089 2018
5
Demographic and clinicopathologic distribution of head and neck malignant tumors in pediatric patients from a Brazilian population: A retrospective study. 61
29729040 2018
6
Desensitization of Brentuximab Vedotin in a Patient with Hodgkin Lymphoma. 61
30237942 2018
7
Chronic Prurigo: An Unusual Presentation of Hodgkin Lymphoma. 61
29928200 2018
8
Hodgkin's lymphoma arising in a case of mycosis fungoides: An unusual association. 61
29098990 2018
9
Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies. 61
29157092 2018
10
Human Herpesvirus 6 and Malignancy: A Review. 61
30542640 2018
11
Neutrophil-lymphocyte ratio at diagnosis is an independent prognostic factor in patients with nodular sclerosis Hodgkin lymphoma: results of a large multicenter study involving 990 patients. 61
27791277 2017
12
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. 61
29196614 2017
13
Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma. 61
28042455 2017
14
Primary Hodgkin's Lymphoma of the Sternum: Report of a Case and Review of the Literature. 61
27504392 2016
15
Frequency of epstein-barr virus in classical hodgkin Lymphoma. 61
28718560 2016
16
Hodgkin lymphoma in a patient with mosaic trisomy 18: First clinical observation. 61
26701824 2016
17
Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes: a case report. 61
26715530 2015
18
Prevalence of Common Non-Hodgkin Lymphomas and Subtypes of Hodgkin Lymphoma by Nodal Site of Involvement: A Systematic Retrospective Review of 938 Cases. 61
26107683 2015
19
Absolute Monocyte Count and Lymphocyte-Monocyte Ratio Predict Outcome in Nodular Sclerosis Hodgkin Lymphoma: Evaluation Based on Data From 1450 Patients. 61
26046410 2015
20
[Brentuximab vedotin and cord blood transplantation for primary refractory Hodgkin lymphoma following autologous hematopoietic stem cell transplantation]. 61
26256882 2015
21
Relapsed Hodgkin's Lymphoma Presenting with Isolated Ulcerative Lesion on Base of Tongue. 61
25332616 2014
22
A prospective study of mediastinal gray-zone lymphoma. 61
25024303 2014
23
Nodular sclerosis Hodgkin lymphoma with classic Reed-Sternberg cells. 61
25259393 2014
24
Reed-Sternberg cells detected in the bone marrow aspirate in a young patient with nodular sclerosis Hodgkin lymphoma. 61
23902293 2014
25
Relapsed nodular sclerosis Hodgkin lymphoma and therapy-related myeloid sarcoma in a mediastinal mass. 61
24716232 2014
26
Latitude gradients for lymphoid neoplasm subtypes in Australia support an association with ultraviolet radiation exposure. 61
23382012 2013
27
Chromosomal integration of the HHV-6 genome in a patient with nodular sclerosis Hodgkin lymphoma. 61
23406281 2013
28
Using biologic predictive factors to direct therapy of diffuse large B-cell lymphoma. 61
23610613 2013
29
Classical Hodgkin's lymphoma infiltrated both lungs. 61
23289089 2012
30
Hodgkin's lymphoma presents as an inguinal abscess: a case report and literature review. 61
23001092 2012
31
Human herpesvirus 6 positive Reed-Sternberg cells in nodular sclerosis Hodgkin lymphoma. 61
22757777 2012
32
[Primary mediastinal lymphoma; a clinicopathologic case series]. 61
22750825 2012
33
Identification of stromal proteins overexpressed in nodular sclerosis Hodgkin lymphoma. 61
21975223 2011
34
[Gastric mantle cell lymphoma followed with nodular sclerosis Hodgkin lymphoma: a case report and literature review]. 61
22339835 2011
35
Testicular mass in an elderly patient: a rare presentation of Hodgkin's lymphoma. 61
22714614 2011
36
Lymphoma in HIV patients: Varied presentations. 61
20931022 2010
37
Sarcoid Reactions after Chemotherapy for Hodgkin's Lymphoma. 61
21769250 2010
38
Frosted branch angiitis with undiagnosed Hodgkin lymphoma. 61
19253256 2009
39
Serum YKL-40 and interleukin 6 levels in Hodgkin lymphoma. 61
18980992 2008
40
PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma. 61
18594468 2008
41
Patterns of spectrin expression in B-cell lymphomas: loss of spectrin isoforms is associated with nodule-forming and germinal center-related lymphomas. 61
17885671 2007
42
Gastrosplenic fistula in Hodgkin's lymphoma treated successfully by laparoscopic surgery and chemotherapy. 61
18060225 2007
43
Classical nodular sclerosis Hodgkin lymphoma presenting with central nervous system disease. 61
17534105 2007
44
Classical Hodgkin's lymphoma presenting as a testicular mass: report of a case. 61
17478785 2007
45
Hodgkin's lymphoma of the thyroid: a clinicopathologic study of five cases and review of the literature. 61
16258502 2005
46
[Ductal regeneration in vanishing bile duct syndrome in Hodgkin's lymphoma]. 61
15871809 2005
47
Hematologic malignancies with primary retroperitoneal presentation: clinicopathologic study of 32 cases. 61
15859638 2005
48
Pathology case of the month. A mediastinal mass. Malignant lymphoma, composite (nodular sclerosis Hodgkin lymphoma and diffuse large B-cell lymphoma). 61
15688668 2004
49
[Pancoast syndrome and endobronchial tumor infiltration as the first manifestation of Hodgkin lymphoma]. 61
15161597 2004
50
Comparison of Epstein-Barr virus presence in Hodgkin lymphoma in pediatric versus adult Argentine patients. 61
14521462 2003

Variations for Hodgkin's Lymphoma, Nodular Sclerosis

Expression for Hodgkin's Lymphoma, Nodular Sclerosis

Search GEO for disease gene expression data for Hodgkin's Lymphoma, Nodular Sclerosis.

Pathways for Hodgkin's Lymphoma, Nodular Sclerosis

Pathways related to Hodgkin's Lymphoma, Nodular Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 TNFRSF8 PAX5 CD79A BCL6
2 10.78 PAX5 BCL6

GO Terms for Hodgkin's Lymphoma, Nodular Sclerosis

Sources for Hodgkin's Lymphoma, Nodular Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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