Aliases & Classifications for Homosexuality 1

MalaCards integrated aliases for Homosexuality 1:

Name: Homosexuality 1 57
Homosexuality, Male 57 13
Sexual Orientation, Male 57
Male Homosexuality 17
Hms1 57

Characteristics:

OMIM:

57
Inheritance:
x-linked (xq28)


HPO:

32
homosexuality 1:
Inheritance x-linked inheritance


External Ids:

OMIM 57 306995
MedGen 42 C1415621

Summaries for Homosexuality 1

MalaCards based summary : Homosexuality 1, also known as homosexuality, male, is related to acquired immunodeficiency syndrome and kaposi sarcoma. The drugs Imidacloprid and Contraceptive Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, hypothalamus and brain.

More information from OMIM: 306995

Related Diseases for Homosexuality 1

Diseases related to Homosexuality 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 acquired immunodeficiency syndrome 10.5
2 kaposi sarcoma 10.4
3 immune deficiency disease 10.3
4 hepatitis b 10.2
5 sarcoma 10.2
6 spindle cell sarcoma 10.2
7 lymphoma 10.1
8 candidiasis 10.1
9 syphilis 10.1
10 persistent generalized lymphadenopathy 10.1
11 shigellosis 10.1
12 granuloma inguinale 10.1
13 human immunodeficiency virus type 1 10.0
14 cytomegalovirus retinitis 10.0
15 neuroretinitis 10.0
16 exhibitionism 10.0
17 endocarditis 10.0
18 giardiasis 10.0
19 pneumocystosis 10.0
20 fetishism 10.0
21 hepatitis a 10.0
22 diarrhea 10.0
23 pedophilia 10.0
24 lymphogranuloma venereum 10.0
25 anus cancer 10.0
26 oral candidiasis 10.0
27 hepatitis c 10.0
28 viral hepatitis 10.0
29 proctitis 10.0
30 retinitis 10.0
31 human immunodeficiency virus infectious disease 10.0
32 pneumonia 10.0
33 lymphopenia 10.0
34 t-cell leukemia 10.0
35 bacterial pneumonia 10.0
36 stomatitis 10.0
37 leukemia, t-cell, chronic 10.0
38 transsexualism 9.9
39 burkitt lymphoma 9.8
40 cardiac conduction defect 9.8
41 hand skill, relative 9.8
42 torticollis 9.8
43 lymphoma, hodgkin, classic 9.8
44 neuroblastoma 1 9.8
45 aging 9.8
46 dermatitis, atopic 9.8
47 lymphoma, non-hodgkin, familial 9.8
48 allergic rhinitis 9.8
49 hepatitis c virus 9.8
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8

Graphical network of the top 20 diseases related to Homosexuality 1:



Diseases related to Homosexuality 1

Symptoms & Phenotypes for Homosexuality 1

Symptoms via clinical synopsis from OMIM:

57
Neuro:
homosexual orientation influence

Lab:
smaller interstitial nucleus of the anterior hypothalamus 3 (inah-3) than in heterosexual men
difference in structure of anterior commissure and suprachiasmatic nucleus

Clinical features from OMIM:

306995

Drugs & Therapeutics for Homosexuality 1

Drugs for Homosexuality 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imidacloprid Vet_approved Phase 1 105827-78-9 86418
2 Contraceptive Agents Phase 1
3 Contraceptive Agents, Male Phase 1
4 Anti-Infective Agents Phase 1
5 Spermatocidal Agents Phase 1
6 Nonoxynol Phase 1
7
Emtricitabine Approved, Investigational 143491-57-0 60877
8
Dolutegravir Approved 1051375-16-6 54726191
9
Tenofovir Experimental, Investigational 147127-20-6 464205
10 Antibodies
11 Immunologic Factors
12 Immunoglobulins
13 Nucleic Acid Synthesis Inhibitors
14 Reverse Transcriptase Inhibitors
15 Anti-HIV Agents
16 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
17 Antiviral Agents
18 Raltegravir Potassium
19 Anti-Retroviral Agents

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Randomized Clinical Trial of the Efficacy of a Behavioral Intervention to Prevent Acquisition of HIV Among Men Who Have Sex With Men Completed NCT00000931 Phase 3
2 Prevention of HIV Infection in Youth at Risk: Developing Community-Level Intervention Strategies That Work (Community Intervention Trial for Youth (CITY) Study) Completed NCT00164580 Phase 2, Phase 3
3 Evaluation of Many Men, Many Voices, A Group Intervention for STD/HIV Prevention for Black Men Who Have Sex With Men (MSM) in the New York Metropolitan Area by People of Color in Crisis, Brooklyn, NY Completed NCT00137631 Phase 1, Phase 2
4 Phase I Rectal Microbicide Study Completed NCT00000929 Phase 1 Nonoxynol-9
5 A Randomized Control Trial of an Internet-based HIV/STI Prevention for Young MSM Receiving HIV Testing. Unknown status NCT00968188
6 Couples HIV Counseling and Testing for Male Couples in the United States Completed NCT01861210
7 Infected Participants Protocol: Evaluation of Natural History of HIV Infection in Newly HIV-Infected Persons in HIVNET Target Populations Completed NCT00000930
8 Intervention Development for Newly Diagnosed Youth With HIV Completed NCT00510237
9 Comparisons of Public Health Screening Methods for Acute and Early HIV Infection: Home Self-Testing for HIV Infection Completed NCT01161446
10 Comprehensive HIV Prevention Package for MSM in Port Elizabeth Completed NCT02449733 Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF)
11 Feasibility and Acceptability Trial of Behavioral Group-based HIV Prevention Intervention for Young Men Who Have Sex With Men (YMSM). Completed NCT01771237
12 Comprehensive HIV Prevention Package for MSM in Southern Africa: Pilot Study Completed NCT02043015 Pre-exposure prophylaxis with FTC/TDF
13 Efficacy Trial of a Brief Health Enhancement Intervention for Newly Diagnosed Men Active, not recruiting NCT01559805

Search NIH Clinical Center for Homosexuality 1

Genetic Tests for Homosexuality 1

Anatomical Context for Homosexuality 1

MalaCards organs/tissues related to Homosexuality 1:

41
Testes, Hypothalamus, Brain

Publications for Homosexuality 1

Articles related to Homosexuality 1:

(show all 19)
# Title Authors PMID Year
1
Extreme skewing of X chromosome inactivation in mothers of homosexual men. 8
16369763 2006
2
A genomewide scan of male sexual orientation. 8
15645181 2005
3
Evidence for maternally inherited factors favouring male homosexuality and promoting female fecundity. 8
15539346 2004
4
Male homosexuality: absence of linkage to microsatellite markers at Xq28. 8
10213693 1999
5
H-Y antigen and homosexuality in men. 8
9156085 1997
6
Linkage between sexual orientation and chromosome Xq28 in males but not in females. 8
7581447 1995
7
Male sexual orientation and genetic evidence. 8
8266107 1993
8
A linkage between DNA markers on the X chromosome and male sexual orientation. 8
8332896 1993
9
Heritable factors influence sexual orientation in women. 8
8439243 1993
10
Familial aggregation of female sexual orientation. 8
8422079 1993
11
Sexual orientation and the size of the anterior commissure in the human brain. 8
1496013 1992
12
A genetic study of male sexual orientation. 8
1845227 1991
13
A difference in hypothalamic structure between heterosexual and homosexual men. 8
1887219 1991
14
An enlarged suprachiasmatic nucleus in homosexual men. 8
2085769 1990
15
Evidence of familial nature of male homosexuality. 8
3729676 1986
16
Chinese Culture, Homosexuality Stigma, Social Support and Condom Use: A Path Analytic Model. 38
21731850 2011
17
[Acalculous cholecystitis and intestinal cryptosporidiosis: frequent association in HIV patients]. 38
7577111 1995
18
Men's and women's reactions to sexually explicit films: a serendipitous finding. 38
742967 1978
19
Childhood indicators of male homosexuality. 38
849142 1977

Variations for Homosexuality 1

Expression for Homosexuality 1

Search GEO for disease gene expression data for Homosexuality 1.

Pathways for Homosexuality 1

GO Terms for Homosexuality 1

Sources for Homosexuality 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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