STYE
MCID: HRD022
MIFTS: 32

Hordeolum (STYE)

Categories: Endocrine diseases, Eye diseases

Aliases & Classifications for Hordeolum

MalaCards integrated aliases for Hordeolum:

Name: Hordeolum 12 44 15 73
Stye 12 76
Hordeolum Externum 73
Furuncle of Eyelid 12
Boil of Eyelid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9909
ICD10 33 H00.01
MeSH 44 D006726
NCIt 50 C118722
SNOMED-CT 68 1489008 74612003

Summaries for Hordeolum

Disease Ontology : 12 Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection.

MalaCards based summary : Hordeolum, also known as stye, is related to internal hordeolum and hordeolum externum. An important gene associated with Hordeolum is IFT122 (Intraflagellar Transport 122), and among its related pathways/superpathways is B Cell Development Pathways. The drugs Levofloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and liver.

Wikipedia : 76 A stye, also known as a hordeolum, is a bacterial infection of an oil gland in the eyelid. This results... more...

Related Diseases for Hordeolum

Diseases in the Hordeolum family:

Internal Hordeolum

Diseases related to Hordeolum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 internal hordeolum 33.7 IFT122 PNP
2 hordeolum externum 12.5
3 meibomian cyst 10.2
4 skin epithelioid hemangioma 10.1 CD34 HBA1
5 ovary sarcoma 10.1 CD34 HBA1
6 ovarian angiosarcoma 10.1 CD34 HBA1
7 intravascular fasciitis 10.1 CD34 HBA1
8 pediatric angiosarcoma 10.1 CD34 HBA1
9 thyroid angiosarcoma 10.1 CD34 HBA1
10 spleen angiosarcoma 10.1 CD34 HBA1
11 bone epithelioid hemangioma 10.1 CD34 HBA1
12 thyroid sarcoma 10.1 CD34 HBA1
13 hobnail hemangioma 10.1 CD34 HBA1
14 glomeruloid hemangioma 10.1 CD34 HBA1
15 hemangioma of liver 10.1 CD34 HBA1
16 spleen cancer 10.1 CD34 HBA1
17 conventional angiosarcoma 10.1 CD34 HBA1
18 venous hemangioma 10.1 CD34 HBA1
19 mixed liposarcoma 10.1 CD34 HBA1
20 erythema elevatum diutinum 10.1 CD34 HBA1
21 breast angiosarcoma 10.1 CD34 HBA1
22 senile angioma 10.1 CD34 HBA1
23 interstitial emphysema 10.1 CD34 HBA1
24 angiomyoma 10.1 CD34 HBA1
25 chorioangioma 10.1 CD34 HBA1
26 spindle cell liposarcoma 10.1 CD34 HBA1
27 alveoli adenoma 10.1 CD34 HBA1
28 mesenchymal cell neoplasm 10.1 CD34 HBA1
29 infiltrating lipoma 10.1 CD34 HBA1
30 hemangioma of intra-abdominal structure 10.1 CD34 HBA1
31 tonsillitis 10.1
32 conjunctivitis 10.1
33 rosacea 10.1
34 orbital cellulitis 10.0
35 cellulitis 10.0
36 pyogenic granuloma 10.0
37 liver angiosarcoma 10.0 CD34 HBA1
38 ovarian solid teratoma 10.0 CD34 TNFRSF8
39 congenital epulis 10.0 CD34 HBA1
40 sternum cancer 10.0 CD34 TNFRSF8
41 paraphimosis 10.0 CD34 TNFRSF8
42 nephrogenic adenofibroma 10.0 CD34 HBA1
43 conventional fibrosarcoma 10.0 CD34 TNFRSF8
44 lymphangiosarcoma 10.0 CD34 HBA1
45 skin sarcoma 10.0 ACRV1 CD34
46 reticulohistiocytic granuloma 10.0 CD34 TNFRSF8
47 vascular cancer 10.0 CD34 HBA1
48 skin benign neoplasm 9.9 CD34 HBA1
49 pediatric lymphoma 9.9 CD34 TNFRSF8
50 connective tissue cancer 9.9 CD34 HBA1

Graphical network of the top 20 diseases related to Hordeolum:



Diseases related to Hordeolum

Symptoms & Phenotypes for Hordeolum

Drugs & Therapeutics for Hordeolum

Drugs for Hordeolum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
2
Ofloxacin Approved Phase 4 82419-36-1 4583
3
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
4
Polyestradiol phosphate Approved Phase 4 28014-46-2
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Metronidazole Approved Phase 4 443-48-1 4173
7
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
8
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
9 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
10
Tobramycin Approved, Investigational Phase 4,Not Applicable 32986-56-4 36294 5496
11
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
12 Contraceptives, Oral, Combined Phase 4
13 Estradiol 3-benzoate Phase 4
14 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
15 Norgestimate, ethinyl estradiol drug combination Phase 4
16 Anti-Infective Agents, Urinary Phase 4
17 Antiparasitic Agents Phase 4
18 Topoisomerase Inhibitors Phase 4
19 Estradiol 17 beta-cypionate Phase 4
20 Contraceptive Agents Phase 4
21 Contraceptives, Oral Phase 4
22 Nucleic Acid Synthesis Inhibitors Phase 4
23 Cytochrome P-450 Enzyme Inhibitors Phase 4
24 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
25 Renal Agents Phase 4
26 Antiprotozoal Agents Phase 4
27 Fluoroquinolones Phase 4
28 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
29 Anti-Allergic Agents Phase 4
30
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
31
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
32
Fluorouracil Approved Phase 3 51-21-8 3385
33 Antibiotics, Antitubercular Phase 3
34 Lubricant Eye Drops Phase 3
35 Ophthalmic Solutions Phase 3,Phase 1,Phase 2
36 Polymyxin B Phase 3
37 Polymyxins Phase 3
38 Antitubercular Agents Phase 3
39 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
40 Anti-Infective Agents, Local Phase 3
41 Gramicidin Phase 3
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
43 Hormone Antagonists Phase 3,Not Applicable
44 Hormones Phase 3,Not Applicable
45 Anti-Inflammatory Agents Phase 3,Not Applicable
46 glucocorticoids Phase 3,Not Applicable
47 triamcinolone acetonide Phase 3
48 Antimetabolites, Antineoplastic Phase 3
49 Immunologic Factors Phase 3,Not Applicable
50 Triamcinolone diacetate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Trial to Assess Moxifloxacin in Treating Community-Acquired Pneumonia (CAP) With Aspiration Factors Unknown status NCT00752947 Phase 4 moxifloxacin;levofloxacin;metronidazole
2 Pediatric Zylet Safety and Efficacy Study Completed NCT00420628 Phase 4 loteprednol etabonate/tobramycin opthalmic suspension;vehicle
3 Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage Unknown status NCT00534391 Phase 3 neomycin sulfate, polymyxin B sulfate and gramicidin;Artificial tear
4 Chalazia Treatment Study Recruiting NCT02025023 Phase 3 5-fluorouracil Injection;Triamcinolone Acetonide;Triamcinolone Acetonide/5-fluorouracil mixture
5 Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion. Unknown status NCT02300818 Phase 1, Phase 2 Seawater eyedrops
6 Generalized Anxiety Disorder Proof of Concept Efficacy and Safety Study of SEP-225441 (Eszopiclone) In GAD Subjects Completed NCT00616655 Phase 2 eszopiclone;eszopiclone;Placebo
7 Chalazion Conservative Treatment Trial Completed NCT01230593 Not Applicable Hot Compress plus Tobramycin Drops and Ointment;Hot compress plus Tobramycin/Dexamethasone Drops and Ointment
8 Comparison of DSM-IV-TR and DSM-5 for ASD Completed NCT02296502
9 Absorb IV Randomized Controlled Trial Active, not recruiting NCT02173379 Not Applicable
10 ABSORB III Randomized Controlled Trial (RCT) Active, not recruiting NCT01751906 Not Applicable

Search NIH Clinical Center for Hordeolum

Cochrane evidence based reviews: hordeolum

Genetic Tests for Hordeolum

Anatomical Context for Hordeolum

MalaCards organs/tissues related to Hordeolum:

41
Eye, Skin, Liver, Bone, Ovary, Spleen, Thyroid

Publications for Hordeolum

Articles related to Hordeolum:

(show all 25)
# Title Authors Year
1
Cover Image: Dermoscopic detection of unusual eyelash Trichophyton interdigitale infection mimicking hordeolum. ( 29668092 )
2018
2
Non-surgical interventions for acute internal hordeolum. ( 28068454 )
2017
3
Hordeolum ( 28723014 )
2017
4
Acupuncture for acute hordeolum. ( 28181687 )
2017
5
Hordeolum: Acute abscess within an eyelid sebaceous gland. ( 27168505 )
2016
6
Pneumo-orbita mimicking hordeolum. ( 26559044 )
2015
7
Acupuncture for acute hordeolum. ( 25214814 )
2014
8
Hemorrhagic pyogenic granuloma after internal hordeolum. ( 25625065 )
2014
9
Interventions for acute internal hordeolum. ( 23633345 )
2013
10
Current pattern treatment of hordeolum by ophthalmologists in Thailand. ( 21696082 )
2011
11
Interventions for acute internal hordeolum. ( 20824865 )
2010
12
An Elderly Woman with Unresolved 'Stye' Over her Right Lower Eye Lid. ( 25606211 )
2010
13
Inadvertent ocular perforation during lid anesthesia for hordeolum removal. ( 17004638 )
2006
14
Cloning and functional characterization of the styE gene, involved in styrene transport in Pseudomonas putida CA-3. ( 16461680 )
2006
15
Effectiveness of combined antibiotic ophthalmic solution in the treatment of hordeolum after incision and curettage: a randomized, placebo-controlled trial: a pilot study. ( 16149682 )
2005
16
Extensive corneal epithelial defect associated with internal hordeolum after uneventful laser in situ keratomileusis. ( 12231335 )
2002
17
Treatment of hordeolum by bloodletting at ear apex. ( 11789331 )
2001
18
Treatment of recurrent hordeolum with Broncasma Berna. ( 10696340 )
1999
19
The common stye. ( 2016867 )
1991
20
Staphylococcus aureus hordeolum as a cause of bacteremia and secondary foci. ( 2794893 )
1989
21
Surgical treatment of a chalazion or hordeolum internum. ( 3675336 )
1987
22
External hordeolum (sty) caused by infection with trichophyton mentagrophytes. ( 873673 )
1977
23
Munomycin in hordeolum externum. ( 5923490 )
1966
24
Stye. ( 18152224 )
1949
25
Orbital Cellulitis Following Hordeolum. ( 16692709 )
1925

Variations for Hordeolum

Expression for Hordeolum

Search GEO for disease gene expression data for Hordeolum.

Pathways for Hordeolum

Pathways related to Hordeolum according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.35 CD34 TNFRSF8

GO Terms for Hordeolum

Biological processes related to Hordeolum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicarbonate transport GO:0015701 8.62 CA3 HBA1

Sources for Hordeolum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....