STYE
MCID: HRD022
MIFTS: 28

Hordeolum (STYE)

Categories: Endocrine diseases, Eye diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Hordeolum

MalaCards integrated aliases for Hordeolum:

Name: Hordeolum 12 44 15 17 70
Stye 12 73
Hordeolum Externum 70
Furuncle of Eyelid 12
Boil of Eyelid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9909
MeSH 44 D006726
NCIt 50 C118722
SNOMED-CT 67 74612003
ICD10 32 H00.01
UMLS 70 C0019917 C0019919

Summaries for Hordeolum

Disease Ontology : 12 Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection.

MalaCards based summary : Hordeolum, also known as stye, is related to internal hordeolum and meibomian cyst. An important gene associated with Hordeolum is MTRNR2L6 (MT-RNR2 Like 6). The drugs Tobramycin and Loteprednol have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 73 A stye, also known as a hordeolum, is a bacterial infection of an oil gland in the eyelid. This results... more...

Related Diseases for Hordeolum

Diseases in the Hordeolum family:

Internal Hordeolum

Diseases related to Hordeolum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 internal hordeolum 31.0 MTRNR2L6 MTRNR2L5 GUK1 DR1
2 meibomian cyst 30.7 MTRNR2L6 MTRNR2L5
3 hordeolum externum 11.3
4 cellulitis 10.0
5 bell's palsy 10.0 MTRNR2L5 CD4
6 xerophthalmia 9.9 MTRNR2L5 CD4
7 facial nerve disease 9.9 MTRNR2L5 CD4
8 epidemic typhus 9.9
9 entropion 9.9
10 scrub typhus 9.9
11 ectropion 9.9
12 rosacea 9.9
13 orbital cellulitis 9.9
14 agammaglobulinemia 9.9
15 endophthalmitis 9.9
16 blepharitis 9.9
17 pyogenic granuloma 9.9
18 facial paralysis 9.9 MTRNR2L5 CD4
19 endocardium disease 9.8 GUK1 CD4
20 salivary gland disease 9.7 GUK1 CD4
21 optic nerve disease 9.5 RBPMS CD4

Graphical network of the top 20 diseases related to Hordeolum:



Diseases related to Hordeolum

Symptoms & Phenotypes for Hordeolum

Drugs & Therapeutics for Hordeolum

Drugs for Hordeolum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
2
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Anti-Allergic Agents Phase 4
6
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
7
Polymyxin B Approved, Vet_approved Phase 3 1404-26-8
8 Pharmaceutical Solutions Phase 3
9 Antibiotics, Antitubercular Phase 3
10 Gramicidin Phase 3
11 Polymyxins Phase 3
12 Ophthalmic Solutions Phase 3
13 Anti-Infective Agents, Local Phase 3
14 Lubricant Eye Drops Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Safety and Efficacy Study of Zylet® (Loteprednol Etabonate 0.5% and Tobramycin 0.3% Ophthalmic Suspension) Compared to Vehicle in the Management of Lid Inflammation (Chalazion/Hordeolum) in Pediatric Subjects Completed NCT00420628 Phase 4 loteprednol etabonate/tobramycin opthalmic suspension;vehicle
2 Dose Antibiotic Need in Hordeolum After Incision and Curettage? : A Randomized, Placebo-controlled Trial Unknown status NCT00534391 Phase 3 neomycin sulfate, polymyxin B sulfate and gramicidin;Artificial tear

Search NIH Clinical Center for Hordeolum

Cochrane evidence based reviews: hordeolum

Genetic Tests for Hordeolum

Anatomical Context for Hordeolum

MalaCards organs/tissues related to Hordeolum:

40
Eye

Publications for Hordeolum

Articles related to Hordeolum:

(show top 50) (show all 115)
# Title Authors PMID Year
1
Increased incidence of chalazion associated with face mask wear during the COVID-19 pandemic. 61
33585724 2021
2
Stye Can Lie! - A Rare Presentation of Scrub Typhus Eschar. 61
32495216 2021
3
Safety and Efficacy of an Augmented Intense Pulse Light Protocol for Dry Eye Syndrome and Blepharitis. 61
33370543 2021
4
Trend in the use of topical ocular anti-infectives in a region of Spain between 2015 and 2019: a population-based registry study. 61
33103400 2020
5
Common inflammatory and infectious conditions of the eyelid. 61
32622681 2020
6
Tarsal Epithelial Cysts: Prevalence, Case Series, and Synthesis of Existing Literature. 61
32826823 2020
7
Bloodletting at EX-HN6 as an adjunctive therapy to eye drops for stye: A meta-analysis. 61
32769896 2020
8
[Effect of bloodletting at tip of ear with different amounts on pain in patients with early-stage stye: a randomized controlled trial]. 61
32869593 2020
9
Current status of eye disorders caused by docetaxel administration every 3 weeks: A case-control study in Japanese patients. 61
31446870 2020
10
The KS-Pexy: A Novel Method to Manage Horizontal Lower Eyelid Laxity. 61
31985625 2020
11
Dupilumab-Associated Blepharoconjunctivitis with Giant Papillae. 61
32801940 2020
12
[Periocular metastasis as differential diagnosis of pyogenic granuloma and therapeutic marker of a systemic disease]. 61
30874885 2019
13
Eyelid lesions in general practice. 61
31370126 2019
14
Pattern of ocular morbidities: A cross-sectional study on school-going children in Shillong city. 61
31334191 2019
15
A Case of Ocular Kaposi's Sarcoma Successfully Treated with Highly Active Antiretroviral Therapy (HAART) Combined with Docetaxel. 61
30197412 2018
16
Pharmacoepidemiological Observational Study of Antimicrobial Use in Outpatients of Ophthalmology Department in North Indian Population. 61
29962795 2018
17
Cover Image: Dermoscopic detection of unusual eyelash Trichophyton interdigitale infection mimicking hordeolum. 61
29668092 2018
18
Risk Factors for Eye Disorders Caused by Paclitaxel: A Retrospective Study. 61
30381669 2018
19
The trend of resistance to antibiotics for ocular infection of Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium compared with 10-years previous: A retrospective observational study. 61
30192856 2018
20
Eyelash extension use among female students in a Tertiary Institution in Nigeria: A study of kaduna polytechnic, Kaduna. 61
29379000 2017
21
The association between diabetes, level of glycaemic control and eye infection: Cohort database study. 61
28648963 2017
22
Prevalence of ocular morbidity in school going children in West Uttar Pradesh. 61
28643716 2017
23
Incidence of Ophthalmic Disorders in Patients Treated with the Antineoplastic Agent S-1. 61
28698442 2017
24
Parents' awareness and perception of children's eye diseases in Nigeria. 61
27423689 2017
25
Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome. 61
28511470 2017
26
Acupuncture for acute hordeolum. 61
28181687 2017
27
[Merkel cell carcinoma of the eyelid. An often unrecognized tumor entity : Clinical aspects and treatment strategies]. 61
27651329 2017
28
Demodicosis Treatment with Systemic Ivermectin. 61
28859743 2017
29
Non-surgical interventions for acute internal hordeolum. 61
28068454 2017
30
Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review. 61
28095664 2016
31
Comparative Clinical Outcomes of Pediatric Patients Presenting With Eyelid Nodules of Idiopathic Facial Aseptic Granuloma, Hordeola, and Chalazia. 61
27182747 2016
32
Evaluation of the Painful Eye. 61
27304768 2016
33
[In any case a stye it is not!]. 61
27221429 2016
34
Hordeolum: Acute abscess within an eyelid sebaceous gland. 61
27168505 2016
35
[Clinical Features Analysis of Demodectic Blephartis Observed in 40 Patients]. 61
30124258 2016
36
Blepharokeratoconjunctivitis in childhood: corneal involvement and visual outcome. 61
26634709 2016
37
Pneumo-orbita mimicking hordeolum. 61
26559044 2016
38
Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population. 61
27965892 2016
39
Analysis of online patient education materials in pediatric ophthalmology. 61
26486024 2015
40
Pharmacokinetics and safety of co-administered paritaprevir plus ritonavir, ombitasvir, and dasabuvir in hepatic impairment. 61
26070406 2015
41
Differential Diagnosis of the Swollen Red Eyelid. 61
26176369 2015
42
Eye Injuries Among Primary School Children in Enugu, Nigeria: Rural vs Urban. 61
26124686 2015
43
Hemorrhagic pyogenic granuloma after internal hordeolum. 61
25625065 2014
44
Acupuncture for acute hordeolum. 61
25214814 2014
45
Functional characterization of a StyS sensor kinase reveals distinct domains associated with intracellular and extracellular sensing of styrene in P. putida CA-3. 61
24637704 2014
46
[Bloodletting at ear apex combined with acupoint application at Yongquan (KI 1) for 21 cases of hordeolum]. 61
24796055 2014
47
[Measurement of the index of infection by Demodex spp in patients with chronic blepharitis and in patients without other ocular diseases]. 61
24248163 2013
48
[Exploration on the application characteristics of bloodletting therapy for the diseases relevant with soft tissue infection by data mining technology]. 61
24298772 2013
49
Trends in ophthalmic manifestations of methicillin-resistant Staphylococcus aureus (MRSA) in a northern California pediatric population. 61
23623773 2013
50
Interventions for acute internal hordeolum. 61
23633345 2013

Variations for Hordeolum

Expression for Hordeolum

Search GEO for disease gene expression data for Hordeolum.

Pathways for Hordeolum

GO Terms for Hordeolum

Biological processes related to Hordeolum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of signaling receptor activity GO:2000272 8.96 MTRNR2L6 MTRNR2L5
2 negative regulation of execution phase of apoptosis GO:1900118 8.62 MTRNR2L6 MTRNR2L5

Molecular functions related to Hordeolum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor antagonist activity GO:0048019 8.62 MTRNR2L6 MTRNR2L5

Sources for Hordeolum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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