Aliases & Classifications for Hordeolum

MalaCards integrated aliases for Hordeolum:

Name: Hordeolum 12 44 15 73
Stye 12 76
Hordeolum Externum 73
Furuncle of Eyelid 12
Boil of Eyelid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9909
ICD10 33 H00.01
MeSH 44 D006726
NCIt 50 C118722
UMLS 73 C0019917

Summaries for Hordeolum

Disease Ontology : 12 Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection.

MalaCards based summary : Hordeolum, also known as stye, is related to internal hordeolum and hordeolum externum. An important gene associated with Hordeolum is IFT122 (Intraflagellar Transport 122). The drugs Moxifloxacin and Ofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotype is Reduced mammosphere formation.

Wikipedia : 76 A stye, also known as a hordeolum, is a bacterial infection of an oil gland in the eyelid. This results... more...

Related Diseases for Hordeolum

Diseases in the Hordeolum family:

Internal Hordeolum

Diseases related to Hordeolum via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 internal hordeolum 32.7 IFT122 PNP
2 hordeolum externum 12.3
3 meibomian cyst 10.0
4 orbital cellulitis 9.9
5 cellulitis 9.9
6 pyogenic granuloma 9.9

Graphical network of the top 20 diseases related to Hordeolum:



Diseases related to Hordeolum

Symptoms & Phenotypes for Hordeolum

GenomeRNAi Phenotypes related to Hordeolum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 CCL20 NDUFB8 TCOF1 CA3

Drugs & Therapeutics for Hordeolum

Drugs for Hordeolum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
2
Ofloxacin Approved Phase 4 82419-36-1 4583
3 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
4
Metronidazole Approved Phase 4 443-48-1 4173
5
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
8
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
9
Polyestradiol phosphate Approved Phase 4 28014-46-2
10
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
11
Tobramycin Approved, Investigational Phase 4,Not Applicable 32986-56-4 5496 36294
12 Renal Agents Phase 4
13 Fluoroquinolones Phase 4
14 Contraceptive Agents Phase 4
15 Contraceptives, Oral Phase 4
16 Contraceptives, Oral, Combined Phase 4
17 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4
19 Topoisomerase Inhibitors Phase 4
20 Norgestimate, ethinyl estradiol drug combination Phase 4
21 Nucleic Acid Synthesis Inhibitors Phase 4
22 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
23 Estradiol 17 beta-cypionate Phase 4
24 Estradiol 3-benzoate Phase 4
25 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
26 Antiparasitic Agents Phase 4
27 Antiprotozoal Agents Phase 4
28 Anti-Allergic Agents Phase 4
29
Neomycin Approved, Vet_approved Phase 3 1404-04-2 8378
30
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
31
Fluorouracil Approved Phase 3 51-21-8 3385
32 Gramicidin Phase 3
33 Polymyxin B Phase 3
34 Tetrahydrozoline Phase 3,Phase 1,Phase 2
35 Ophthalmic Solutions Phase 3,Phase 1,Phase 2
36 Antibiotics, Antitubercular Phase 3
37 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
38 Polymyxins Phase 3
39 Anti-Infective Agents, Local Phase 3
40 Lubricant Eye Drops Phase 3
41 Antitubercular Agents Phase 3
42 triamcinolone acetonide Phase 3
43 glucocorticoids Phase 3
44 Hormone Antagonists Phase 3
45 Triamcinolone diacetate Phase 3
46 Triamcinolone hexacetonide Phase 3
47 Hormones Phase 3
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
49 Immunosuppressive Agents Phase 3,Not Applicable
50 Anti-Inflammatory Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Trial to Assess Moxifloxacin in Treating Community-Acquired Pneumonia (CAP) With Aspiration Factors Unknown status NCT00752947 Phase 4 moxifloxacin;levofloxacin;metronidazole
2 Pediatric Zylet Safety and Efficacy Study Completed NCT00420628 Phase 4 loteprednol etabonate/tobramycin opthalmic suspension;vehicle
3 Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage Unknown status NCT00534391 Phase 3 neomycin sulfate, polymyxin B sulfate and gramicidin;Artificial tear
4 Chalazia Treatment Study Recruiting NCT02025023 Phase 3 5-fluorouracil Injection;Triamcinolone Acetonide;Triamcinolone Acetonide/5-fluorouracil mixture
5 Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion. Unknown status NCT02300818 Phase 1, Phase 2 Seawater eyedrops
6 Generalized Anxiety Disorder Proof of Concept Efficacy and Safety Study of SEP-225441 (Eszopiclone) In GAD Subjects Completed NCT00616655 Phase 2 eszopiclone;eszopiclone;Placebo
7 Chalazion Conservative Treatment Trial Completed NCT01230593 Not Applicable Hot Compress plus Tobramycin Drops and Ointment;Hot compress plus Tobramycin/Dexamethasone Drops and Ointment
8 Comparison of DSM-IV-TR and DSM-5 for ASD Completed NCT02296502
9 Absorb IV Randomized Controlled Trial Active, not recruiting NCT02173379 Not Applicable
10 ABSORB III Randomized Controlled Trial (RCT) Active, not recruiting NCT01751906 Not Applicable

Search NIH Clinical Center for Hordeolum

Cochrane evidence based reviews: hordeolum

Genetic Tests for Hordeolum

Anatomical Context for Hordeolum

MalaCards organs/tissues related to Hordeolum:

41
Eye

Publications for Hordeolum

Articles related to Hordeolum:

(show all 21)
# Title Authors Year
1
Cover Image: Dermoscopic detection of unusual eyelash Trichophyton interdigitale infection mimicking hordeolum. ( 29668092 )
2018
2
Non-surgical interventions for acute internal hordeolum. ( 28068454 )
2017
3
Hordeolum ( 28723014 )
2017
4
Acupuncture for acute hordeolum. ( 28181687 )
2017
5
Hordeolum: Acute abscess within an eyelid sebaceous gland. ( 27168505 )
2016
6
Pneumo-orbita mimicking hordeolum. ( 26559044 )
2015
7
Acupuncture for acute hordeolum. ( 25214814 )
2014
8
Hemorrhagic pyogenic granuloma after internal hordeolum. ( 25625065 )
2014
9
Interventions for acute internal hordeolum. ( 23633345 )
2013
10
Current pattern treatment of hordeolum by ophthalmologists in Thailand. ( 21696082 )
2011
11
Interventions for acute internal hordeolum. ( 20824865 )
2010
12
Inadvertent ocular perforation during lid anesthesia for hordeolum removal. ( 17004638 )
2006
13
Effectiveness of combined antibiotic ophthalmic solution in the treatment of hordeolum after incision and curettage: a randomized, placebo-controlled trial: a pilot study. ( 16149682 )
2005
14
Extensive corneal epithelial defect associated with internal hordeolum after uneventful laser in situ keratomileusis. ( 12231335 )
2002
15
Treatment of hordeolum by bloodletting at ear apex. ( 11789331 )
2001
16
Treatment of recurrent hordeolum with Broncasma Berna. ( 10696340 )
1999
17
Staphylococcus aureus hordeolum as a cause of bacteremia and secondary foci. ( 2794893 )
1989
18
Surgical treatment of a chalazion or hordeolum internum. ( 3675336 )
1987
19
External hordeolum (sty) caused by infection with trichophyton mentagrophytes. ( 873673 )
1977
20
Munomycin in hordeolum externum. ( 5923490 )
1966
21
Orbital Cellulitis Following Hordeolum. ( 16692709 )
1925

Variations for Hordeolum

Expression for Hordeolum

Search GEO for disease gene expression data for Hordeolum.

Pathways for Hordeolum

GO Terms for Hordeolum

Biological processes related to Hordeolum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 8.8 CCL20 PNP TNFRSF8

Sources for Hordeolum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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