MCID: HRM003
MIFTS: 32

Hormone Producing Pituitary Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Hormone Producing Pituitary Cancer

MalaCards integrated aliases for Hormone Producing Pituitary Cancer:

Name: Hormone Producing Pituitary Cancer 12 15
Growth Hormone-Producing Pituitary Gland Neoplasm 73
Growth Hormone Producing Pituitary Tumor 12
Pituitary Tumors, Hormone Producing 12
Somatotropinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5716
NCIt 50 C7047 C7911

Summaries for Hormone Producing Pituitary Cancer

MalaCards based summary : Hormone Producing Pituitary Cancer, also known as growth hormone-producing pituitary gland neoplasm, is related to pituitary adenoma 1, multiple types and pituitary adenoma. An important gene associated with Hormone Producing Pituitary Cancer is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Signaling by GPCR and Development Dopamine D2 receptor transactivation of EGFR. Affiliated tissues include pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Hormone Producing Pituitary Cancer

Diseases related to Hormone Producing Pituitary Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 1, multiple types 32.8 AIP IGF1 SST
2 pituitary adenoma 31.0 AIP GNAS
3 functioning pituitary adenoma 30.2 AIP MEN1 SST
4 pituitary tumors 27.8 AIP GNAS IGF1 MEN1 SST SSTR5
5 adenoma 26.9 AIP GNAS IGF1 MEN1 SST SSTR2
6 acromegaly 26.2 AIP GNAS IGF1 MEN1 SST SSTR2
7 pituitary adenoma 2, growth hormone-secreting 10.9
8 malignant growth hormone secreting neoplasm of pituitary 10.9
9 silent pituitary adenoma 10.6 AIP MEN1
10 null pituitary adenoma 10.6 AIP MEN1
11 pancreatic gastrinoma 10.4 MEN1 SST
12 villous adenoma 10.4 GNAS SST
13 pancreatic somatostatinoma 10.4 MEN1 SST
14 pancreatic cholera 10.3 MEN1 SST
15 duodenal gastrinoma 10.3 MEN1 SST
16 zollinger-ellison syndrome 10.3 MEN1 SST
17 gastrinoma 10.3 MEN1 SST
18 duodenum cancer 10.3 MEN1 SST
19 type c thymoma 10.3 SST SSTR2
20 ectopic cushing syndrome 10.3 MEN1 SST
21 pituitary carcinoma 10.2 SST SSTR2
22 islet cell tumor 10.2 MEN1 SST
23 pseudohypoparathyroidism, type ia 10.2 GNAS IGF1
24 pancreatic endocrine carcinoma 10.2 SSTR2 SSTR5
25 acidophil adenoma 10.2 IGF1 SST
26 pituitary infarct 10.2 IGF1 SST
27 serotonin syndrome 10.2 MEN1 SST
28 mixed ductal-endocrine carcinoma 10.1 SST SSTR2
29 non-functioning pituitary adenoma 10.1
30 endocrine gland cancer 10.0 GNAS MEN1 SST
31 pseudopseudohypoparathyroidism 10.0 GNAS PRKAR1A
32 acrodysostosis 10.0 GNAS PRKAR1A
33 albright's hereditary osteodystrophy 9.9 GNAS PRKAR1A
34 hypocalcemia, autosomal dominant 1 9.9 GNAS PRKAR1A
35 endocrine pancreas disease 9.9 IGF1 SST
36 pancreas disease 9.9 IGF1 SST
37 carcinoid tumors, intestinal 9.8 MEN1 SST SSTR2
38 short bowel syndrome 9.8 IGF1 SST
39 adrenal cortex disease 9.8 PRKAR1A SST
40 neuroendocrine tumor 9.8 MEN1 SST SSTR2
41 hyperpituitarism 9.8 AIP IGF1 SST
42 adrenal gland disease 9.8 PRKAR1A SST
43 thyroid cancer, nonmedullary, 2 9.8 MEN1 SST SSTR2
44 lipomatosis 9.8 MEN1 PRKAR1A
45 meningioma, familial 9.7 MEN1 SST SSTR2
46 mccune-albright syndrome 9.7 GNAS IGF1 SST
47 fibrous dysplasia 9.7 GNAS IGF1 SST
48 carcinoid syndrome 9.7 IGF1 MEN1 SST
49 pituitary gland disease 9.7 IGF1 MEN1 SST
50 multiple endocrine neoplasia, type iv 9.6 AIP MEN1 PRKAR1A

Graphical network of the top 20 diseases related to Hormone Producing Pituitary Cancer:



Diseases related to Hormone Producing Pituitary Cancer

Symptoms & Phenotypes for Hormone Producing Pituitary Cancer

GenomeRNAi Phenotypes related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.84 SSTR2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.84 IGF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.84 PRKAR1A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.84 IGF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.84 PRKAR1A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.84 SSTR2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.84 SSTR2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.84 SSTR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.84 SSTR2 IGF1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.84 SSTR2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.84 SSTR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.84 PRKAR1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.84 IGF1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.84 IGF1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.84 PRKAR1A SSTR2 IGF1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.84 IGF1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.84 PRKAR1A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.84 PRKAR1A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.84 IGF1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.84 IGF1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.84 SSTR2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.84 IGF1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.84 PRKAR1A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.84 PRKAR1A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.84 SSTR2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.84 SSTR2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.84 SSTR2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.84 SSTR2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.84 SSTR2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.84 IGF1

MGI Mouse Phenotypes related to Hormone Producing Pituitary Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 MEN1 PRKAR1A SSTR2 AIP GNAS IGF1
2 endocrine/exocrine gland MP:0005379 9.73 MEN1 PRKAR1A SSTR5 AIP GNAS IGF1
3 growth/size/body region MP:0005378 9.7 MEN1 PRKAR1A SST SSTR5 AIP GNAS
4 homeostasis/metabolism MP:0005376 9.56 PRKAR1A SST SSTR2 AIP SSTR5 GNAS
5 neoplasm MP:0002006 9.02 MEN1 PRKAR1A AIP GNAS IGF1

Drugs & Therapeutics for Hormone Producing Pituitary Cancer

Search Clinical Trials , NIH Clinical Center for Hormone Producing Pituitary Cancer

Genetic Tests for Hormone Producing Pituitary Cancer

Anatomical Context for Hormone Producing Pituitary Cancer

MalaCards organs/tissues related to Hormone Producing Pituitary Cancer:

41
Pituitary

Publications for Hormone Producing Pituitary Cancer

Articles related to Hormone Producing Pituitary Cancer:

# Title Authors Year
1
Change in Somatostatinergic Tone of Acromegalic Patients according to the Size of Growth Hormone-Producing Pituitary Tumors. ( 24339708 )
2013
2
Unusual type of growth hormone-producing pituitary tumor in acromegaly. ( 22638653 )
2012
3
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH? ( 22170724 )
2012
4
Cavernous sinus invasion and tumor proliferative potential of growth hormone-producing pituitary tumors. ( 10890190 )
2000
5
Antiproliferative effect of the somatostatin analogue octreotide on growth hormone-producing pituitary tumors: results of a multicenter randomized trial. ( 9379690 )
1997
6
Stereotactic radiosurgery with the cobalt-60 gamma unit in the treatment of growth hormone-producing pituitary tumors. ( 1961394 )
1991
7
Shrinking of a growth hormone-producing pituitary tumor by continuous subcutaneous infusion of the somatostatin analog SMS 201-995. ( 2889748 )
1987

Variations for Hormone Producing Pituitary Cancer

Expression for Hormone Producing Pituitary Cancer

Search GEO for disease gene expression data for Hormone Producing Pituitary Cancer.

Pathways for Hormone Producing Pituitary Cancer

GO Terms for Hormone Producing Pituitary Cancer

Biological processes related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of insulin secretion GO:0050796 9.46 GNAS SSTR5
2 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.43 SSTR2 SSTR5
3 positive regulation of osteoblast differentiation GO:0045669 9.4 GNAS IGF1
4 response to heat GO:0009408 9.37 IGF1 SST
5 cellular response to glucagon stimulus GO:0071377 9.32 GNAS PRKAR1A
6 renal water homeostasis GO:0003091 9.26 GNAS PRKAR1A
7 negative regulation of cell proliferation GO:0008285 9.26 MEN1 SST SSTR2 SSTR5
8 cellular response to glucocorticoid stimulus GO:0071385 9.16 SSTR2 SSTR5
9 somatostatin signaling pathway GO:0038170 8.62 SSTR2 SSTR5

Molecular functions related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide binding GO:0042923 9.16 SSTR2 SSTR5
2 insulin-like growth factor receptor binding GO:0005159 8.96 GNAS IGF1
3 somatostatin receptor activity GO:0004994 8.62 SSTR2 SSTR5

Sources for Hormone Producing Pituitary Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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