MCID: HRM003
MIFTS: 37

Hormone Producing Pituitary Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Hormone Producing Pituitary Cancer

MalaCards integrated aliases for Hormone Producing Pituitary Cancer:

Name: Hormone Producing Pituitary Cancer 12 15
Growth Hormone-Producing Pituitary Gland Neoplasm 73
Growth Hormone Producing Pituitary Tumor 12
Pituitary Tumors, Hormone Producing 12
Somatotropinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5716
NCIt 50 C7047 C7911

Summaries for Hormone Producing Pituitary Cancer

MalaCards based summary : Hormone Producing Pituitary Cancer, also known as growth hormone-producing pituitary gland neoplasm, is related to pituitary adenoma 1, multiple types and pituitary adenoma. An important gene associated with Hormone Producing Pituitary Cancer is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Signaling by GPCR and Development Dopamine D2 receptor transactivation of EGFR. Affiliated tissues include pituitary, cortex and pancreas, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Hormone Producing Pituitary Cancer

Diseases related to Hormone Producing Pituitary Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 1, multiple types 33.2 AIP IGF1 SST
2 pituitary adenoma 30.4 AIP GNAS
3 pituitary tumors 29.6 AIP GNAS IGF1 MEN1 SST SSTR5
4 adenoma 29.2 AIP GNAS IGF1 MEN1 SST SSTR5
5 acromegaly 28.7 AIP GNAS IGF1 MEN1 SST SSTR2
6 pituitary adenoma 2, growth hormone-secreting 11.1
7 malignant growth hormone secreting neoplasm of pituitary 11.1
8 silent pituitary adenoma 10.2 AIP MEN1
9 null pituitary adenoma 10.2 AIP MEN1
10 pituitary carcinoma 10.1 GNAS SST
11 villous adenoma 10.1 GNAS SST
12 pancreatic somatostatinoma 10.1 MEN1 SST
13 multiple endocrine neoplasia 10.1 MEN1 PRKAR1A
14 pancreatic cholera 10.1 MEN1 SST
15 duodenal disease 10.1 MEN1 SST
16 duodenal gastrinoma 10.1 MEN1 SST
17 pseudopseudohypoparathyroidism 10.1 GNAS PRKAR1A
18 gastrinoma 10.1 MEN1 SST
19 acrodysostosis 10.1 GNAS PRKAR1A
20 zollinger-ellison syndrome 10.1 MEN1 SST
21 pancreatic cystadenoma 10.1 MEN1 SST
22 duodenum cancer 10.1 MEN1 SST
23 albright's hereditary osteodystrophy 10.1 GNAS PRKAR1A
24 ectopic cushing syndrome 10.1 MEN1 SST
25 islet cell tumor 10.1 MEN1 SST
26 pseudohypoparathyroidism, type ia 10.1 GNAS IGF1
27 gastrointestinal system benign neoplasm 10.1 MEN1 SST
28 acidophil adenoma 10.0 IGF1 SST
29 pituitary infarct 10.0 IGF1 SST
30 paraganglioma 10.0
31 serotonin syndrome 10.0 MEN1 SST
32 lipomatosis 10.0 MEN1 PRKAR1A
33 adrenal cortex disease 10.0 PRKAR1A SST
34 hypocalcemia, autosomal dominant 1 10.0 GNAS PRKAR1A
35 small intestine cancer 10.0 MEN1 SST
36 endocrine pancreas disease 10.0 IGF1 SST
37 adrenal gland disease 10.0 PRKAR1A SST
38 pancreas disease 10.0 IGF1 SST
39 endocrine gland cancer 10.0 GNAS MEN1 SST
40 multiple endocrine neoplasia, type iv 10.0 AIP MEN1 PRKAR1A
41 isolated growth hormone deficiency, type ii 10.0 IGF1 SST
42 type c thymoma 10.0 SST SSTR2
43 primary pigmented nodular adrenocortical disease 10.0 GNAS PRKAR1A
44 functioning pituitary adenoma 9.9 MEN1 SST SSTR5
45 hyperinsulinemic hypoglycemia 9.9 MEN1 SST
46 mixed ductal-endocrine carcinoma 9.9 SST SSTR2
47 hyperpituitarism 9.9 AIP IGF1 SST
48 short bowel syndrome 9.9 IGF1 SST
49 mccune-albright syndrome 9.9 GNAS IGF1 SST
50 fibrous dysplasia 9.9 GNAS IGF1 SST

Graphical network of the top 20 diseases related to Hormone Producing Pituitary Cancer:



Diseases related to Hormone Producing Pituitary Cancer

Symptoms & Phenotypes for Hormone Producing Pituitary Cancer

GenomeRNAi Phenotypes related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.84 SSTR2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.84 IGF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.84 PRKAR1A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.84 IGF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.84 PRKAR1A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.84 SSTR2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.84 SSTR2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.84 SSTR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.84 IGF1 SSTR2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.84 SSTR2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.84 SSTR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.84 PRKAR1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.84 IGF1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.84 IGF1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.84 IGF1 PRKAR1A SSTR2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.84 IGF1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.84 PRKAR1A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.84 PRKAR1A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.84 IGF1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.84 IGF1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.84 SSTR2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.84 IGF1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.84 PRKAR1A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.84 PRKAR1A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.84 SSTR2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.84 SSTR2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.84 SSTR2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.84 SSTR2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.84 SSTR2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.84 IGF1

MGI Mouse Phenotypes related to Hormone Producing Pituitary Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 AIP GNAS IGF1 MEN1 PRKAR1A SSTR2
2 endocrine/exocrine gland MP:0005379 9.73 AIP GNAS IGF1 MEN1 PRKAR1A SSTR5
3 growth/size/body region MP:0005378 9.7 AIP GNAS IGF1 MEN1 PRKAR1A SST
4 homeostasis/metabolism MP:0005376 9.56 AIP GNAS IGF1 MEN1 PRKAR1A SST
5 neoplasm MP:0002006 9.02 AIP GNAS IGF1 MEN1 PRKAR1A

Drugs & Therapeutics for Hormone Producing Pituitary Cancer

Search Clinical Trials , NIH Clinical Center for Hormone Producing Pituitary Cancer

Genetic Tests for Hormone Producing Pituitary Cancer

Anatomical Context for Hormone Producing Pituitary Cancer

MalaCards organs/tissues related to Hormone Producing Pituitary Cancer:

41
Pituitary, Cortex, Pancreas, Thyroid, Small Intestine, Adrenal Gland, Adrenal Cortex

Publications for Hormone Producing Pituitary Cancer

Articles related to Hormone Producing Pituitary Cancer:

# Title Authors Year
1
Unusual type of growth hormone-producing pituitary tumor in acromegaly. ( 22638653 )
2012
2
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH? ( 22170724 )
2012
3
Shrinking of a growth hormone-producing pituitary tumor by continuous subcutaneous infusion of the somatostatin analog SMS 201-995. ( 2889748 )
1987

Variations for Hormone Producing Pituitary Cancer

Expression for Hormone Producing Pituitary Cancer

Search GEO for disease gene expression data for Hormone Producing Pituitary Cancer.

Pathways for Hormone Producing Pituitary Cancer

Pathways related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 GNAS IGF1 MEN1 PRKAR1A SST SSTR2
2
Show member pathways
12.22 GNAS IGF1 PRKAR1A
3
Show member pathways
11.95 AIP GNAS MEN1
4
Show member pathways
11.82 GNAS IGF1 PRKAR1A
5
Show member pathways
11.74 GNAS SSTR2 SSTR5
6
Show member pathways
11.35 GNAS SST SSTR2
7 11.34 GNAS IGF1 PRKAR1A
8 11.31 GNAS IGF1
9 11.2 GNAS IGF1
10 11.16 GNAS SSTR2
11 11.02 GNAS PRKAR1A
12 11.01 PRKAR1A SST SSTR2
13 10.96 GNAS IGF1 PRKAR1A
14 10.52 GNAS PRKAR1A

GO Terms for Hormone Producing Pituitary Cancer

Biological processes related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of insulin secretion GO:0050796 9.46 GNAS SSTR5
2 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.43 SSTR2 SSTR5
3 positive regulation of osteoblast differentiation GO:0045669 9.4 GNAS IGF1
4 response to heat GO:0009408 9.37 IGF1 SST
5 renal water homeostasis GO:0003091 9.32 GNAS PRKAR1A
6 cellular response to glucagon stimulus GO:0071377 9.26 GNAS PRKAR1A
7 negative regulation of cell proliferation GO:0008285 9.26 MEN1 SST SSTR2 SSTR5
8 cellular response to glucocorticoid stimulus GO:0071385 9.16 SSTR2 SSTR5
9 somatostatin signaling pathway GO:0038170 8.62 SSTR2 SSTR5

Molecular functions related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide binding GO:0042923 9.16 SSTR2 SSTR5
2 insulin-like growth factor receptor binding GO:0005159 8.96 GNAS IGF1
3 somatostatin receptor activity GO:0004994 8.62 SSTR2 SSTR5

Sources for Hormone Producing Pituitary Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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