MCID: HRM003
MIFTS: 37

Hormone Producing Pituitary Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Hormone Producing Pituitary Cancer

MalaCards integrated aliases for Hormone Producing Pituitary Cancer:

Name: Hormone Producing Pituitary Cancer 12 15
Growth Hormone-Producing Pituitary Gland Neoplasm 71
Growth Hormone Producing Pituitary Tumor 12
Pituitary Tumors, Hormone Producing 12
Somatotropinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5716
NCIt 49 C7047 C7911
UMLS 71 C0278864 C0851693

Summaries for Hormone Producing Pituitary Cancer

MalaCards based summary : Hormone Producing Pituitary Cancer, also known as growth hormone-producing pituitary gland neoplasm, is related to pituitary adenoma 1, multiple types and familial isolated pituitary adenoma. An important gene associated with Hormone Producing Pituitary Cancer is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Somatostatin and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, colon and thyroid, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Hormone Producing Pituitary Cancer

Diseases related to Hormone Producing Pituitary Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 1, multiple types 33.4 SST PRL MEN1 IGF1 AIP
2 familial isolated pituitary adenoma 32.8 MEN1 CDKN1B AIP
3 multiple endocrine neoplasia 30.8 PRKAR1A MEN1 CDKN1B
4 gigantism 30.4 PRL GPR101 GHRH AIP
5 adrenal cortical carcinoma 30.1 PRKAR1A POMC MEN1
6 goiter 30.0 SST PRL IGF1 GNAS
7 sexual disorder 29.9 PRL POMC IGF1
8 adrenal carcinoma 29.9 SST PRKAR1A POMC MEN1
9 amenorrhea 29.9 PRL POMC IGF1
10 hyperthyroidism 29.5 SST PRL POMC IGF1 GNAS
11 hypopituitarism 29.4 PRL POMC IGF1 GHRH
12 pituitary tumors 29.3 SSTR5 SST PRL POMC MEN1 IGF1
13 mccune-albright syndrome 29.1 SST PRL PRKAR1A MEN1 IGF1 GPR101
14 hyperprolactinemia 29.0 SST PRL POMC IGF1 GNAS GHRH
15 multiple endocrine neoplasia, type i 28.2 SST PRL PRKAR1A POMC MEN1 GPR101
16 acth-secreting pituitary adenoma 28.0 SSTR5 SSTR2 SSTR1 SST PRL PRKAR1A
17 carney complex variant 27.9 SST PRL PRKAR1A POMC MEN1 IGF1
18 adenoma 27.4 SSTR5 SSTR2 SST PRL PRKAR1A POMC
19 pituitary adenoma, prolactin-secreting 25.8 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
20 pituitary adenoma 25.7 SSTR5 SSTR3 SSTR2 SST PRL PRKAR1A
21 acromegaly 25.6 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
22 pituitary adenoma 2, growth hormone-secreting 11.2
23 malignant growth hormone secreting neoplasm of pituitary 11.2
24 null pituitary adenoma 10.5 MEN1 AIP
25 silent pituitary adenoma 10.5 MEN1 AIP
26 gastrointestinal neuroendocrine benign tumor 10.4 SST MEN1
27 non-functioning pancreatic endocrine tumor 10.4 SST MEN1
28 fibrous dysplasia/mccune-albright syndrome 10.4 PRL GNAS
29 gastric neuroendocrine neoplasm 10.4 SST MEN1
30 duodenal gastrinoma 10.4 SST MEN1
31 pancreatic gastrinoma 10.4 SST MEN1
32 breast ductal adenoma 10.4 PRL PRKAR1A
33 type c thymoma 10.4 SSTR2 SST
34 duodenal somatostatinoma 10.4 SST MEN1
35 galactorrhea 10.3 PRL IGF1
36 acth-independent cushing syndrome 10.3 PRKAR1A GNAS
37 breast adenoma 10.3 PRL PRKAR1A
38 carcinoid tumors, intestinal 10.3 SSTR2 SST MEN1
39 spinocerebellar degeneration 10.3 SST PRL
40 pulmonary neuroendocrine tumor 10.3 SSTR2 SST MEN1
41 bronchial adenomas/carcinoids childhood 10.3 SST POMC
42 mammographic density 10.3 PRL IGF1
43 acth-independent macronodular adrenal hyperplasia 1 10.2 POMC GNAS
44 chiasmal syndrome 10.2 SST POMC
45 hypoparathyroidism 10.2 PRKAR1A IGF1 GNAS
46 basophil adenoma 10.2 PRKAR1A POMC
47 hypothalamic obesity 10.2 IGF1 GHRH
48 adenohypophysitis 10.2 PRL POMC
49 acth-dependent cushing syndrome 10.2 PRL POMC
50 tuberculum sellae meningioma 10.2 PRL POMC

Graphical network of the top 20 diseases related to Hormone Producing Pituitary Cancer:



Diseases related to Hormone Producing Pituitary Cancer

Symptoms & Phenotypes for Hormone Producing Pituitary Cancer

MGI Mouse Phenotypes related to Hormone Producing Pituitary Cancer:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 AIP CDKN1B GHRH GNAS GPR101 IGF1
2 behavior/neurological MP:0005386 10.22 CDKN1B GHRH GNAS POMC PRKAR1A PRL
3 cardiovascular system MP:0005385 10.16 AIP CDKN1B GNAS GPR101 IGF1 MEN1
4 endocrine/exocrine gland MP:0005379 10.13 AIP CDKN1B GHRH GNAS IGF1 MEN1
5 immune system MP:0005387 10.07 CDKN1B GHRH GNAS IGF1 MEN1 POMC
6 adipose tissue MP:0005375 9.97 CDKN1B GHRH GNAS IGF1 POMC PRKAR1A
7 integument MP:0010771 9.92 AIP CDKN1B GNAS IGF1 POMC PRKAR1A
8 liver/biliary system MP:0005370 9.86 AIP CDKN1B GHRH GNAS MEN1 POMC
9 neoplasm MP:0002006 9.76 AIP CDKN1B GNAS IGF1 MEN1 POMC
10 nervous system MP:0003631 9.65 CDKN1B GHRH GNAS IGF1 MEN1 POMC
11 no phenotypic analysis MP:0003012 9.1 CDKN1B GNAS POMC SST SSTR3 SSTR4

Drugs & Therapeutics for Hormone Producing Pituitary Cancer

Drugs for Hormone Producing Pituitary Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
2 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
3 Edotreotide Phase 1
4 Radiopharmaceuticals Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Antineoplastons A10 and AS2-1 in Patients With Metastatic or Incurable Neuroendocrine Tumors Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
2 An Open Label, Multicenter, Phase II Study Evaluating the Safety and Efficacy of Temozolomide Treatment in Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
3 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
4 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671
5 Impact of a Physical Rehabilitation Program on the Quality of Life of Patients With Acromegaly: a Non-randomized Clinical Trial. Recruiting NCT03710499

Search NIH Clinical Center for Hormone Producing Pituitary Cancer

Genetic Tests for Hormone Producing Pituitary Cancer

Anatomical Context for Hormone Producing Pituitary Cancer

MalaCards organs/tissues related to Hormone Producing Pituitary Cancer:

40
Pituitary, Colon, Thyroid, Testes

Publications for Hormone Producing Pituitary Cancer

Articles related to Hormone Producing Pituitary Cancer:

(show top 50) (show all 101)
# Title Authors PMID Year
1
Molecular profiling for acromegaly treatment: a validation study. 61
32302973 2020
2
Pituicytoma Associated with Acromegaly and Cushing Disease. 61
31874293 2020
3
Accuracy of microcystic aspect on T2-weighted MRI for the diagnosis of silent corticotroph adenomas. 61
31773787 2020
4
Surgery, Octreotide, Temozolomide, Bevacizumab, Radiotherapy, and Pegvisomant Treatment of an AIP Mutation‒Positive Child. 61
31125088 2019
5
Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas. 61
30376114 2019
6
Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. 61
30318257 2019
7
[Evaluation of transsphenoidal adenomectomy outcomes in acromegaly using different remission criteria]. 61
30900693 2019
8
Malignant paraganglioma and somatotropinoma in a patient with germline SDHB mutation-genetic and clinical features. 61
30155846 2019
9
Screening of AIP Gene Variations in a Cohort of Turkish Patients with Young-Onset Sporadic Hormone-Secreting Pituitary Adenomas. 61
30461320 2018
10
Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas. 61
29729370 2018
11
Screening for germline KCNQ1 and KCNE2 mutations in a set of somatotropinoma patients. 61
29703730 2018
12
Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas. 61
29670116 2018
13
Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland. 61
29507682 2018
14
Imatinib Inhibits GH Secretion From Somatotropinomas. 61
30210447 2018
15
The genetic background of acromegaly. 61
28161730 2017
16
Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues. 61
28396686 2017
17
Genetic and clinical characteristics of Japanese patients with sporadic somatotropinoma. 61
27498687 2016
18
Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening. 61
27287035 2016
19
Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas. 61
27185868 2016
20
A novel truncating AIP mutation, p.W279*, in a familial isolated pituitary adenoma (FIPA) kindred. 61
27838609 2016
21
Long-term first line medical treatment in a 4-year-old girl with Xq26.3 microduplication-negative somatotropinoma. Case report and literature review. 61
26812771 2016
22
[Mental disorders in patients with acromegaly]. 61
27735894 2016
23
The Role of gsp Mutations on the Development of Adrenocortical Tumors and Adrenal Hyperplasia. 61
27512387 2016
24
Hemostatic Disorders in Hormonally Active Pituitary Tumors. 61
26285071 2015
25
Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. 61
25637790 2015
26
Familial acromegaly due to aryl hydrocarbon receptor-interacting protein (AIP) gene mutation in a Turkish cohort. 61
23743763 2014
27
Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas. 61
25291362 2014
28
A clinically novel AIP mutation in a patient with a very large, apparently sporadic somatotrope adenoma. 61
25136448 2014
29
Screening for AIP gene mutations in a Han Chinese pituitary adenoma cohort followed by LOH analysis. 61
24050928 2013
30
Characterization of SNARE proteins in human pituitary adenomas: targeted secretion inhibitors as a new strategy for the treatment of acromegaly? 61
24152687 2013
31
Complex rhythmicity and age dependence of growth hormone secretion are preserved in patients with acromegaly: further evidence for a present hypothalamic control of pituitary somatotropinomas. 61
23640965 2013
32
Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. 61
23371967 2013
33
Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis. 61
23321498 2013
34
Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor. 61
22527616 2012
35
AIP Familial Isolated Pituitary Adenomas 61
22720333 2012
36
Validation of immunohistochemistry for somatostatin receptor subtype 2A in human somatotropinomas: comparison between quantitative real time RT-PCR and immunohistochemistry. 61
21897115 2012
37
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH? 61
22170724 2012
38
'Silent' somatotropinoma. 61
22538745 2012
39
Growth of an aggressive tumor during pregnancy in an acromegalic patient. 61
22240890 2012
40
Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience. 61
21750393 2011
41
High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas. 61
21753072 2011
42
Sporadic and genetic forms of paediatric somatotropinoma: a retrospective analysis of seven cases and a review of the literature. 61
22024364 2011
43
Acrogigantism and facial asymmetry: McCune-Albright syndrome. 61
22145488 2011
44
Familial acromegaly - case study of two sisters with acromegaly. 61
22144223 2011
45
Clinical features and treatment of pediatric somatotropinoma: case study of an aggressive tumor due to a new AIP mutation and extensive literature review. 61
21546764 2011
46
Thyrotropin secreting pituitary adenoma accompanying a silent somatotropinoma. 61
21845579 2011
47
Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening. 61
21340155 2010
48
Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study. 61
20685857 2010
49
Relationship between cytokeratin staining patterns and clinico-pathological features in somatotropinomae. 61
20688896 2010
50
[Sexual function rehabilitation of men with pituitary tumors]. 61
20973135 2010

Variations for Hormone Producing Pituitary Cancer

Expression for Hormone Producing Pituitary Cancer

Search GEO for disease gene expression data for Hormone Producing Pituitary Cancer.

Pathways for Hormone Producing Pituitary Cancer

Pathways related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
2
Show member pathways
13.14 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
3
Show member pathways
12.54 POMC MEN1 GNAS CDKN1B AIP
4
Show member pathways
11.87 SSTR5 SSTR3 SSTR2 SSTR1 SST POMC
5 11.83 SSTR2 SSTR1 SST PRKAR1A
6 11.8 POMC GNAS GHRH
7 11.77 SSTR5 SSTR2 SSTR1 SST POMC GNAS
8 11.4 PRKAR1A IGF1 GNAS GHRH
9 10.84 PRKAR1A GNAS
10 10.73 PRL POMC

GO Terms for Hormone Producing Pituitary Cancer

Cellular components related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.1 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 GHRH

Biological processes related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.1 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 PRL
2 G protein-coupled receptor signaling pathway GO:0007186 9.96 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
3 cell-cell signaling GO:0007267 9.85 SSTR3 SST POMC GPR101 GHRH
4 negative regulation of cell proliferation GO:0008285 9.76 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
5 forebrain development GO:0030900 9.73 SSTR4 SSTR3 SSTR2 SSTR1
6 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.72 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
7 cerebellum development GO:0021549 9.7 SSTR3 SSTR2 SSTR1
8 response to starvation GO:0042594 9.67 SSTR3 SSTR2 SSTR1
9 cellular response to glucocorticoid stimulus GO:0071385 9.67 SSTR5 SSTR4 SSTR3 SSTR2
10 cellular response to estradiol stimulus GO:0071392 9.65 SSTR3 SSTR2 SSTR1
11 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.56 GPR101 GNAS
12 regulation of protein kinase A signaling GO:0010738 9.55 PRKAR1A AIP
13 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.54 IGF1 GHRH
14 hormone-mediated apoptotic signaling pathway GO:0008628 9.51 SSTR3 SST
15 neuropeptide signaling pathway GO:0007218 9.43 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 POMC
16 somatostatin signaling pathway GO:0038170 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Molecular functions related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.8 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 GPR101
2 hormone activity GO:0005179 9.65 SST PRL POMC IGF1 GHRH
3 peptide binding GO:0042277 9.55 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
4 insulin-like growth factor receptor binding GO:0005159 9.37 IGF1 GNAS
5 neuropeptide binding GO:0042923 9.35 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
6 somatostatin receptor activity GO:0004994 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Sources for Hormone Producing Pituitary Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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