MCID: HRM003
MIFTS: 33

Hormone Producing Pituitary Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Hormone Producing Pituitary Cancer

MalaCards integrated aliases for Hormone Producing Pituitary Cancer:

Name: Hormone Producing Pituitary Cancer 12 15
Growth Hormone-Producing Pituitary Gland Neoplasm 71
Growth Hormone Producing Pituitary Tumor 12
Pituitary Tumors, Hormone Producing 12
Somatotropinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5716
NCIt 50 C7047 C7911
UMLS 71 C0278864 C0851693

Summaries for Hormone Producing Pituitary Cancer

MalaCards based summary : Hormone Producing Pituitary Cancer, also known as growth hormone-producing pituitary gland neoplasm, is related to pituitary adenoma 1, multiple types and familial isolated pituitary adenoma. An important gene associated with Hormone Producing Pituitary Cancer is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include pituitary and thyroid, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Hormone Producing Pituitary Cancer

Diseases related to Hormone Producing Pituitary Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 1, multiple types 32.2 SST PRL MEN1 IGF1 AIP
2 familial isolated pituitary adenoma 31.9 MEN1 AIP
3 pituitary tumors 29.8 SSTR5 SST PRL POMC MEN1 IGF1
4 goiter 29.7 SST PRL IGF1 GNAS
5 sexual disorder 29.7 PRL POMC IGF1
6 gigantism 29.6 PRL GPR101 GHRH AIP
7 multiple endocrine neoplasia 29.6 SST PRKAR1A POMC MEN1 GNAS AIP
8 adrenal cortical carcinoma 29.6 PRKAR1A POMC GNAS
9 adrenal carcinoma 29.6 PRKAR1A POMC MEN1 GNAS
10 hyperthyroidism 29.3 SST PRL POMC IGF1 GNAS
11 hyperprolactinemia 28.9 SST PRL POMC IGF1 GNAS GHRH
12 mccune-albright syndrome 28.9 SST PRL PRKAR1A PDE11A MEN1 IGF1
13 multiple endocrine neoplasia, type i 28.7 SST PRL PRKAR1A POMC MEN1 GPR101
14 acromegaly 28.2 SSTR5 SSTR2 SSTR1 SST PRL PRKAR1A
15 adenoma 28.0 SSTR5 SSTR2 SST PRL PRKAR1A POMC
16 carney complex variant 28.0 SST PRL PRKAR1A POMC PDE11A MEN1
17 pituitary adenoma 27.4 SSTR5 SSTR3 SSTR2 SST PRL PRKAR1A
18 pituitary adenoma, prolactin-secreting 26.8 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
19 pituitary adenoma 2, growth hormone-secreting 11.1
20 malignant growth hormone secreting neoplasm of pituitary 10.9
21 null pituitary adenoma 10.4 MEN1 AIP
22 silent pituitary adenoma 10.3 MEN1 AIP
23 gastrointestinal neuroendocrine benign tumor 10.3 SST MEN1
24 non-functioning pancreatic endocrine tumor 10.3 SST MEN1
25 duodenal gastrinoma 10.3 SST MEN1
26 gastric neuroendocrine neoplasm 10.3 SST MEN1
27 duodenal somatostatinoma 10.3 SST MEN1
28 type c thymoma 10.3 SSTR2 SST
29 pancreatic gastrinoma 10.3 SST MEN1
30 small intestine neuroendocrine neoplasm 10.3 SST MEN1
31 fibrous dysplasia/mccune-albright syndrome 10.3 PRL GNAS
32 small intestine benign neoplasm 10.2 SST MEN1
33 carcinoid tumors, intestinal 10.2 SSTR2 SST MEN1
34 galactorrhea 10.2 PRL IGF1
35 bronchial adenomas/carcinoids childhood 10.2 SST POMC
36 chiasmal syndrome 10.2 SST POMC
37 acth-independent macronodular adrenal hyperplasia 1 10.2 POMC GNAS
38 adenohypophysitis 10.1 PRL POMC
39 hypothalamic obesity 10.1 IGF1 GHRH
40 endocrine pancreas disease 10.1 SST MEN1 GHRH
41 pancreatic cholera 10.1 SST MEN1 GHRH
42 partial third-nerve palsy 10.1 PRL IGF1
43 hypoparathyroidism 10.1 PRKAR1A IGF1 GNAS
44 colon neuroendocrine neoplasm 10.1 SST POMC
45 chromophobe adenoma 10.1 PRL POMC
46 abducens nerve disease 10.1 PRL POMC
47 bladder cancer 10.1
48 sleep apnea 10.1
49 transitional cell carcinoma 10.1
50 seminoma 10.1

Graphical network of the top 20 diseases related to Hormone Producing Pituitary Cancer:



Diseases related to Hormone Producing Pituitary Cancer

Symptoms & Phenotypes for Hormone Producing Pituitary Cancer

MGI Mouse Phenotypes related to Hormone Producing Pituitary Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 AIP GHRH GNAS GPR101 IGF1 MEN1
2 behavior/neurological MP:0005386 10.14 GHRH GNAS PDE11A POMC PRKAR1A PRL
3 endocrine/exocrine gland MP:0005379 10.07 AIP GHRH GNAS IGF1 MEN1 PDE11A
4 immune system MP:0005387 9.96 GHRH GNAS GPR101 IGF1 MEN1 POMC
5 liver/biliary system MP:0005370 9.7 AIP GHRH GNAS MEN1 POMC PRKAR1A
6 neoplasm MP:0002006 9.5 AIP GNAS IGF1 MEN1 POMC PRKAR1A
7 nervous system MP:0003631 9.32 GHRH GNAS IGF1 MEN1 PDE11A POMC

Drugs & Therapeutics for Hormone Producing Pituitary Cancer

Search Clinical Trials , NIH Clinical Center for Hormone Producing Pituitary Cancer

Genetic Tests for Hormone Producing Pituitary Cancer

Anatomical Context for Hormone Producing Pituitary Cancer

MalaCards organs/tissues related to Hormone Producing Pituitary Cancer:

40
Pituitary, Thyroid

Publications for Hormone Producing Pituitary Cancer

Articles related to Hormone Producing Pituitary Cancer:

(show top 50) (show all 104)
# Title Authors PMID Year
1
Molecular profiling for acromegaly treatment: a validation study. 61
32302973 2020
2
Current Status of Diagnosis and Management for Functioning Pituitary Tumors: Part I. 61
32611887 2020
3
Pituicytoma Associated with Acromegaly and Cushing Disease. 61
31874293 2020
4
Somatostatin receptors in normal and acromegalic somatotroph cells: the U-turn of the clinician to immunohistochemistry report - a review. 61
33544787 2020
5
Accuracy of microcystic aspect on T2-weighted MRI for the diagnosis of silent corticotroph adenomas. 61
31773787 2020
6
Somatic Deletion in Exon 10 of Aryl Hydrocarbon Receptor Gene in Human GH-Secreting Pituitary Tumors. 61
33281746 2020
7
Surgery, Octreotide, Temozolomide, Bevacizumab, Radiotherapy, and Pegvisomant Treatment of an AIP Mutation‒Positive Child. 61
31125088 2019
8
Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas. 61
30376114 2019
9
Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. 61
30318257 2019
10
[Evaluation of transsphenoidal adenomectomy outcomes in acromegaly using different remission criteria]. 61
30900693 2019
11
Malignant paraganglioma and somatotropinoma in a patient with germline SDHB mutation-genetic and clinical features. 61
30155846 2019
12
Screening of AIP Gene Variations in a Cohort of Turkish Patients with Young-Onset Sporadic Hormone-Secreting Pituitary Adenomas. 61
30461320 2018
13
Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas. 61
29729370 2018
14
Screening for germline KCNQ1 and KCNE2 mutations in a set of somatotropinoma patients. 61
29703730 2018
15
Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas. 61
29670116 2018
16
Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland. 61
29507682 2018
17
Imatinib Inhibits GH Secretion From Somatotropinomas. 61
30210447 2018
18
The genetic background of acromegaly. 61
28161730 2017
19
Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues. 61
28396686 2017
20
Genetic and clinical characteristics of Japanese patients with sporadic somatotropinoma. 61
27498687 2016
21
Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening. 61
27287035 2016
22
Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas. 61
27185868 2016
23
A novel truncating AIP mutation, p.W279*, in a familial isolated pituitary adenoma (FIPA) kindred. 61
27838609 2016
24
Long-term first line medical treatment in a 4-year-old girl with Xq26.3 microduplication-negative somatotropinoma. Case report and literature review. 61
26812771 2016
25
The Role of gsp Mutations on the Development of Adrenocortical Tumors and Adrenal Hyperplasia. 61
27512387 2016
26
[Mental disorders in patients with acromegaly]. 61
27735894 2016
27
Hemostatic Disorders in Hormonally Active Pituitary Tumors. 61
26285071 2015
28
Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. 61
25637790 2015
29
Familial acromegaly due to aryl hydrocarbon receptor-interacting protein (AIP) gene mutation in a Turkish cohort. 61
23743763 2014
30
Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas. 61
25291362 2014
31
A clinically novel AIP mutation in a patient with a very large, apparently sporadic somatotrope adenoma. 61
25136448 2014
32
Screening for AIP gene mutations in a Han Chinese pituitary adenoma cohort followed by LOH analysis. 61
24050928 2013
33
Characterization of SNARE proteins in human pituitary adenomas: targeted secretion inhibitors as a new strategy for the treatment of acromegaly? 61
24152687 2013
34
Complex rhythmicity and age dependence of growth hormone secretion are preserved in patients with acromegaly: further evidence for a present hypothalamic control of pituitary somatotropinomas. 61
23640965 2013
35
Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. 61
23371967 2013
36
Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis. 61
23321498 2013
37
Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor. 61
22527616 2012
38
AIP Familial Isolated Pituitary Adenomas 61
22720333 2012
39
Validation of immunohistochemistry for somatostatin receptor subtype 2A in human somatotropinomas: comparison between quantitative real time RT-PCR and immunohistochemistry. 61
21897115 2012
40
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH? 61
22170724 2012
41
'Silent' somatotropinoma. 61
22538745 2012
42
Growth of an aggressive tumor during pregnancy in an acromegalic patient. 61
22240890 2012
43
Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience. 61
21750393 2011
44
Sporadic and genetic forms of paediatric somatotropinoma: a retrospective analysis of seven cases and a review of the literature. 61
22024364 2011
45
High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas. 61
21753072 2011
46
Acrogigantism and facial asymmetry: McCune-Albright syndrome. 61
22145488 2011
47
Familial acromegaly - case study of two sisters with acromegaly. 61
22144223 2011
48
Clinical features and treatment of pediatric somatotropinoma: case study of an aggressive tumor due to a new AIP mutation and extensive literature review. 61
21546764 2011
49
Thyrotropin secreting pituitary adenoma accompanying a silent somatotropinoma. 61
21845579 2011
50
Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening. 61
21340155 2010

Variations for Hormone Producing Pituitary Cancer

Expression for Hormone Producing Pituitary Cancer

Search GEO for disease gene expression data for Hormone Producing Pituitary Cancer.

Pathways for Hormone Producing Pituitary Cancer

Pathways related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
2
Show member pathways
13.14 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
3
Show member pathways
12.57 POMC PDE11A MEN1 GNAS AIP
4 11.88 SSTR2 SSTR1 SST PRKAR1A
5
Show member pathways
11.87 SSTR5 SSTR3 SSTR2 SSTR1 SST POMC
6 11.79 POMC PDE11A GNAS GHRH
7 11.77 SSTR5 SSTR2 SSTR1 SST POMC GNAS
8 11.42 PRKAR1A IGF1 GNAS GHRH
9 10.84 PRKAR1A GNAS
10 10.76 PRL POMC

GO Terms for Hormone Producing Pituitary Cancer

Cellular components related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Biological processes related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.11 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 PRL
2 negative regulation of cell proliferation GO:0008285 9.95 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
3 cell-cell signaling GO:0007267 9.83 SSTR3 SST POMC GHRH
4 forebrain development GO:0030900 9.73 SSTR4 SSTR3 SSTR2 SSTR1
5 G protein-coupled receptor signaling pathway GO:0007186 9.7 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 SST
6 cerebellum development GO:0021549 9.69 SSTR3 SSTR2 SSTR1
7 response to starvation GO:0042594 9.65 SSTR3 SSTR2 SSTR1
8 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.65 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
9 cellular response to estradiol stimulus GO:0071392 9.63 SSTR3 SSTR2 SSTR1
10 neuropeptide signaling pathway GO:0007218 9.63 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 POMC
11 cellular response to glucocorticoid stimulus GO:0071385 9.62 SSTR5 SSTR4 SSTR3 SSTR2
12 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.56 GPR101 GNAS
13 regulation of protein kinase A signaling GO:0010738 9.55 PRKAR1A AIP
14 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.54 IGF1 GHRH
15 hormone-mediated apoptotic signaling pathway GO:0008628 9.49 SSTR3 SST
16 somatostatin signaling pathway GO:0038170 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Molecular functions related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.8 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 GPR101
2 hormone activity GO:0005179 9.65 SST PRL POMC IGF1 GHRH
3 peptide binding GO:0042277 9.55 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
4 insulin-like growth factor receptor binding GO:0005159 9.37 IGF1 GNAS
5 neuropeptide binding GO:0042923 9.35 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
6 somatostatin receptor activity GO:0004994 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Sources for Hormone Producing Pituitary Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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