MCID: HRM003
MIFTS: 37

Hormone Producing Pituitary Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Hormone Producing Pituitary Cancer

MalaCards integrated aliases for Hormone Producing Pituitary Cancer:

Name: Hormone Producing Pituitary Cancer 12 15
Growth Hormone-Producing Pituitary Gland Neoplasm 72
Growth Hormone Producing Pituitary Tumor 12
Pituitary Tumors, Hormone Producing 12
Somatotropinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5716
NCIt 50 C7047 C7911
UMLS 72 C0278864 C0851693

Summaries for Hormone Producing Pituitary Cancer

MalaCards based summary : Hormone Producing Pituitary Cancer, also known as growth hormone-producing pituitary gland neoplasm, is related to pituitary adenoma 1, multiple types and multiple endocrine neoplasia. An important gene associated with Hormone Producing Pituitary Cancer is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Somatostatin and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, colon and testes, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Hormone Producing Pituitary Cancer

Diseases related to Hormone Producing Pituitary Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 97, show less)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 1, multiple types 33.7 SST IGF1 AIP
2 multiple endocrine neoplasia 30.9 PRKAR1A MEN1
3 pituitary adenoma 30.8 GNAS AIP
4 mccune-albright syndrome 30.0 SST IGF1 GNAS
5 carney complex variant 30.0 PRKAR1A MEN1 GNAS AIP
6 multiple endocrine neoplasia, type i 29.9 SST PRKAR1A MEN1 GNAS
7 hyperprolactinemia 29.6 SST IGF1
8 pituitary tumors 29.1 SSTR5 SST MEN1 IGF1 GNAS AIP
9 adenoma 28.7 SSTR5 SST MEN1 IGF1 GNAS AIP
10 acromegaly 27.1 SSTR5 SSTR2 SSTR1 SST MEN1 IGF1
11 pituitary adenoma, prolactin-secreting 25.6 SSTR5 SSTR2 SSTR1 SST PRKAR1A MEN1
12 familial isolated pituitary adenoma 11.7
13 pituitary adenoma 2, growth hormone-secreting 11.2
14 malignant growth hormone secreting neoplasm of pituitary 11.2
15 null pituitary adenoma 10.5 MEN1 AIP
16 silent pituitary adenoma 10.5 MEN1 AIP
17 pancreatic somatostatinoma 10.4 SST MEN1
18 villous adenoma 10.4 SST GNAS
19 acidophil adenoma 10.4 SST IGF1
20 pancreatic cholera 10.4 SST MEN1
21 pituitary infarct 10.4 SST IGF1
22 gigantism 10.4
23 duodenal gastrinoma 10.4 SST MEN1
24 gastrinoma 10.3 SST MEN1
25 zollinger-ellison syndrome 10.3 SST MEN1
26 pancreatic cystadenoma 10.3 SST MEN1
27 duodenum cancer 10.3 SST MEN1
28 pseudohypoparathyroidism, type ia 10.3 IGF1 GNAS
29 type c thymoma 10.3 SSTR2 SST
30 gastrointestinal system benign neoplasm 10.2 SST MEN1
31 endocrine pancreas disease 10.2 SST IGF1
32 pancreas disease 10.2 SST IGF1
33 islet cell tumor 10.2 SST MEN1
34 mixed ductal-endocrine carcinoma 10.2 SSTR2 SST
35 acroleukopathy, symmetric 10.2
36 pituitary adenoma 4, acth-secreting 10.2
37 acth-secreting pituitary adenoma 10.2
38 diabetes insipidus 10.2
39 isolated growth hormone deficiency, type ii 10.1 SST IGF1
40 pseudopseudohypoparathyroidism 10.1 PRKAR1A GNAS
41 acrodysostosis 10.1 PRKAR1A GNAS
42 small intestine cancer 10.1 SST MEN1
43 hyperpituitarism 10.1 SST IGF1 AIP
44 adrenal cortex disease 10.1 SST PRKAR1A
45 endocrine gland cancer 10.1 SST MEN1 GNAS
46 fibrous dysplasia 10.0 SST IGF1 GNAS
47 adrenal gland disease 10.0 SST PRKAR1A
48 carcinoid syndrome 10.0 SST MEN1 IGF1
49 adrenocortical carcinoma, hereditary 10.0
50 adrenal cortical carcinoma 10.0
51 paraganglioma 10.0
52 sexual disorder 10.0
53 gingival fibromatosis 10.0
54 prostatic hypertrophy 10.0
55 goiter 10.0
56 amenorrhea 10.0
57 hypogonadism 10.0
58 long qt syndrome 10.0
59 prostatic adenoma 10.0
60 adrenal carcinoma 10.0
61 adrenal cortical adenocarcinoma 10.0
62 b-cell lymphoma 10.0
63 hypogonadotropism 10.0
64 hyperthyroidism 10.0
65 aip-related familial isolated pituitary adenomas 10.0
66 fibromatosis 10.0
67 growth hormone deficiency 10.0
68 rare surgical neurologic disease 10.0
69 lipomatosis 10.0 PRKAR1A MEN1
70 bladder cancer 10.0
71 transitional cell carcinoma 10.0
72 seminoma 10.0
73 hypopituitarism 10.0
74 testicular seminoma 10.0
75 short bowel syndrome 10.0 SST IGF1
76 carcinoid tumors, intestinal 10.0 SSTR2 SST MEN1
77 functioning pituitary adenoma 10.0 SSTR5 SST MEN1
78 small intestine neuroendocrine neoplasm 9.9 SSTR1 MEN1
79 intestinal neuroendocrine benign tumor 9.9 SSTR1 MEN1
80 hyperinsulinemic hypoglycemia 9.9 SST MEN1
81 neuroendocrine tumor 9.9 SSTR2 SST MEN1
82 meningioma, familial 9.9 SSTR2 SST MEN1
83 thyroid cancer, nonmedullary, 2 9.9 SSTR2 SST MEN1
84 multiple endocrine neoplasia, type iv 9.9 PRKAR1A MEN1 AIP
85 hypocalcemia, autosomal dominant 1 9.9 PRKAR1A GNAS
86 pancreatic endocrine carcinoma 9.9 SSTR5 SSTR2 SST
87 oncogenic osteomalacia 9.8 SSTR5 SSTR1
88 endocrine organ benign neoplasm 9.7 SST MEN1 IGF1 AIP
89 pituitary gland disease 9.7 SST MEN1 IGF1 AIP
90 ectopic cushing syndrome 9.7 SSTR1 SST MEN1
91 serotonin syndrome 9.7 SSTR1 SST MEN1
92 conn's syndrome 9.5 SST PRKAR1A MEN1 GNAS
93 primary pigmented nodular adrenocortical disease 9.4 SSTR1 PRKAR1A GNAS
94 pheochromocytoma 9.4 SSTR1 SST MEN1
95 growth hormone secreting pituitary adenoma 9.1 SSTR2 SST PRKAR1A GNAS AIP
96 cell type benign neoplasm 8.9 SSTR5 SST MEN1 IGF1 GNAS AIP
97 thyroid carcinoma, familial medullary 8.7 SSTR5 SSTR2 SSTR1 SST MEN1

Graphical network of the top 20 diseases related to Hormone Producing Pituitary Cancer:



Diseases related to Hormone Producing Pituitary Cancer

Symptoms & Phenotypes for Hormone Producing Pituitary Cancer

MGI Mouse Phenotypes related to Hormone Producing Pituitary Cancer:

46 (showing 5, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 AIP GNAS IGF1 MEN1 PRKAR1A SSTR2
2 endocrine/exocrine gland MP:0005379 9.73 AIP GNAS IGF1 MEN1 PRKAR1A SSTR5
3 growth/size/body region MP:0005378 9.7 AIP GNAS IGF1 MEN1 PRKAR1A SST
4 homeostasis/metabolism MP:0005376 9.61 AIP GNAS IGF1 MEN1 PRKAR1A SST
5 neoplasm MP:0002006 9.02 AIP GNAS IGF1 MEN1 PRKAR1A

Drugs & Therapeutics for Hormone Producing Pituitary Cancer

Drugs for Hormone Producing Pituitary Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 7, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
2
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
3 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
4 Gastrointestinal Agents Phase 1
5 Radiopharmaceuticals Phase 1
6 Antineoplastic Agents, Hormonal Phase 1
7 Edotreotide Phase 1

Interventional clinical trials:

(showing 5, show less)
# Name Status NCT ID Phase Drugs
1 Phase II Study of Antineoplastons A10 and AS2-1 in Patients With Metastatic or Incurable Neuroendocrine Tumors Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
2 An Open Label, Multicenter, Phase II Study Evaluating the Safety and Efficacy of Temozolomide Treatment in Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
3 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
4 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671
5 Impact of a Physical Rehabilitation Program on the Quality of Life of Patients With Acromegaly: a Non-randomized Clinical Trial. Recruiting NCT03710499

Search NIH Clinical Center for Hormone Producing Pituitary Cancer

Genetic Tests for Hormone Producing Pituitary Cancer

Anatomical Context for Hormone Producing Pituitary Cancer

MalaCards organs/tissues related to Hormone Producing Pituitary Cancer:

41
Pituitary, Colon, Testes, Thyroid

Publications for Hormone Producing Pituitary Cancer

Articles related to Hormone Producing Pituitary Cancer:

(showing 97, show less)
# Title Authors PMID Year
1
Surgery, Octreotide, Temozolomide, Bevacizumab, Radiotherapy, and Pegvisomant Treatment of an AIP Mutation‒Positive Child. 38
31125088 2019
2
Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas. 38
30376114 2019
3
Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. 38
30318257 2019
4
[Evaluation of transsphenoidal adenomectomy outcomes in acromegaly using different remission criteria]. 38
30900693 2019
5
Malignant paraganglioma and somatotropinoma in a patient with germline SDHB mutation-genetic and clinical features. 38
30155846 2019
6
Screening of AIP Gene Variations in a Cohort of Turkish Patients with Young-Onset Sporadic Hormone-Secreting Pituitary Adenomas. 38
30461320 2018
7
Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas. 38
29729370 2018
8
Screening for germline KCNQ1 and KCNE2 mutations in a set of somatotropinoma patients. 38
29703730 2018
9
Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas. 38
29670116 2018
10
Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland. 38
29507682 2018
11
Imatinib Inhibits GH Secretion From Somatotropinomas. 38
30210447 2018
12
The genetic background of acromegaly. 38
28161730 2017
13
Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues. 38
28396686 2017
14
Genetic and clinical characteristics of Japanese patients with sporadic somatotropinoma. 38
27498687 2016
15
Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening. 38
27287035 2016
16
Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas. 38
27185868 2016
17
A novel truncating AIP mutation, p.W279*, in a familial isolated pituitary adenoma (FIPA) kindred. 38
27838609 2016
18
Long-term first line medical treatment in a 4-year-old girl with Xq26.3 microduplication-negative somatotropinoma. Case report and literature review. 38
26812771 2016
19
[Mental disorders in patients with acromegaly]. 38
27735894 2016
20
The Role of gsp Mutations on the Development of Adrenocortical Tumors and Adrenal Hyperplasia. 38
27512387 2016
21
Hemostatic Disorders in Hormonally Active Pituitary Tumors. 38
26285071 2015
22
Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. 38
25637790 2015
23
Familial acromegaly due to aryl hydrocarbon receptor-interacting protein (AIP) gene mutation in a Turkish cohort. 38
23743763 2014
24
Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas. 38
25291362 2014
25
A clinically novel AIP mutation in a patient with a very large, apparently sporadic somatotrope adenoma. 38
25136448 2014
26
Screening for AIP gene mutations in a Han Chinese pituitary adenoma cohort followed by LOH analysis. 38
24050928 2013
27
Characterization of SNARE proteins in human pituitary adenomas: targeted secretion inhibitors as a new strategy for the treatment of acromegaly? 38
24152687 2013
28
Complex rhythmicity and age dependence of growth hormone secretion are preserved in patients with acromegaly: further evidence for a present hypothalamic control of pituitary somatotropinomas. 38
23640965 2013
29
Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis. 38
23321498 2013
30
Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. 38
23371967 2013
31
Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor. 38
22527616 2012
32
AIP-Related Familial Isolated Pituitary Adenomas 38
22720333 2012
33
Validation of immunohistochemistry for somatostatin receptor subtype 2A in human somatotropinomas: comparison between quantitative real time RT-PCR and immunohistochemistry. 38
21897115 2012
34
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH? 38
22170724 2012
35
Growth of an aggressive tumor during pregnancy in an acromegalic patient. 38
22240890 2012
36
'Silent' somatotropinoma. 38
22538745 2012
37
Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience. 38
21750393 2011
38
High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas. 38
21753072 2011
39
Sporadic and genetic forms of paediatric somatotropinoma: a retrospective analysis of seven cases and a review of the literature. 38
22024364 2011
40
Acrogigantism and facial asymmetry: McCune-Albright syndrome. 38
22145488 2011
41
Clinical features and treatment of pediatric somatotropinoma: case study of an aggressive tumor due to a new AIP mutation and extensive literature review. 38
21546764 2011
42
Thyrotropin secreting pituitary adenoma accompanying a silent somatotropinoma. 38
21845579 2011
43
Familial acromegaly - case study of two sisters with acromegaly. 38
22144223 2011
44
Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening. 38
21340155 2010
45
Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study. 38
20685857 2010
46
Relationship between cytokeratin staining patterns and clinico-pathological features in somatotropinomae. 38
20688896 2010
47
[Sexual function rehabilitation of men with pituitary tumors]. 38
20973135 2010
48
The genetics of pituitary adenomas. 38
20833337 2010
49
Review: Pituitary adenomas in children and adolescents. 38
20662340 2010
50
[Sexual and reproductive function in males with somatotropinoma]. 38
20734880 2010
51
Isolated familial somatotropinoma: 11q13-loh and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesis. 38
20454499 2010
52
Pathogenesis of familial acromegaly. 38
20616502 2010
53
Familial isolated pituitary adenoma: evidence for genetic heterogeneity. 38
20616498 2010
54
Genome-wide scan identifies novel modifier loci of acromegalic phenotypes for isolated familial somatotropinoma. 38
19443539 2009
55
Expression of somatostatin receptor subtypes in human pituitary adenomas -- immunohistochemical studies. 38
19753537 2009
56
Somatotropin adenoma and resistance to thyroid hormone. 38
19542750 2009
57
Effects of rosiglitazone--peroxisome proliferators-activated receptor gamma (PPARgamma) agonist on cell viability of human pituitary adenomas in vitro. 38
19300395 2009
58
Giant somatotropinoma. 38
21687008 2009
59
Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. 38
18642089 2009
60
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. 38
18349058 2008
61
Aquaporin-4 autoantibodies in a paraneoplastic context. 38
18474738 2008
62
Characteristics of familial isolated pituitary adenomas. 38
30290472 2007
63
The clinical, pathological, and genetic features of familial isolated pituitary adenomas. 38
17893250 2007
64
Familial pituitary adenomas with a heterogeneous functional pattern: clinical and genetic features. 38
17993773 2007
65
Germline mutation in the aryl hydrocarbon receptor interacting protein gene in familial somatotropinoma. 38
17341560 2007
66
Clinical characterization of familial isolated pituitary adenomas. 38
16787992 2006
67
Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas. 38
16189251 2005
68
Tumor deletion mapping of chromosomal region 13q14 in 43 growth hormone secreting pituitary adenomas. 38
16388084 2005
69
An overview of the epidemiology and genetics of acromegaly. 38
16625848 2005
70
The efficacy of octreotide LAR (long acting release) treatment in patients with somatotropinoma, and mixed pituitary tumours. 38
15683101 2004
71
A meiotic recombination in a new isolated familial somatotropinoma kindred. 38
15132719 2004
72
Prevalence of colonic polyps is not increased in patients with acromegaly: analysis of 60 patients from India. 38
14748872 2004
73
Isolated familial somatotropinoma. 38
15761658 2004
74
[Transsphenoidal surgery of secretory and invasive pituitary adenomas (somatotropinoma or corticotropinoma)--own experiences]. 38
15803901 2004
75
Acromegaly with fibrous dysplasia: McCune-Albright Syndrome -- clinical studies in 3 cases and brief review of literature--. 38
14709853 2003
76
[Surgical treatment of invasive pituitary adenomas (somatotropinoma or corticotropinoma)]. 38
15174237 2003
77
Effects of treatment with somatostatin analogues on the occurrence of apoptosis in somatotropinomas. 38
14647007 2003
78
Perspectives of new potential therapeutic applications of somatostatin analogs. 38
12743527 2003
79
[Effect of lanreotide on prolactin level in patients with pituitary mixed tumors]. 38
12527855 2002
80
Antibodies to pituitary surface antigens during various pituitary disease states. 38
12429039 2002
81
[The effect of acetylcholine on the proliferation and apoptosis of three kinds of cultured human pituitary adenoma cells]. 38
12075474 2002
82
[Estimation of efficacy of the octreotide LAR administration in the patients with somatotropinoma]. 38
11926144 2001
83
Somatotropinoma infarction during octreotide therapy leading to bilateral cavernous sinus syndrome. 38
11383484 2000
84
Suppression of tyrosine kinase activity inhibits [3H]thymidine uptake in cultured human pituitary tumor cells. 38
9215285 1997
85
Suppression of growth hormone (GH) hypersecretion due to ectopic GH-releasing hormone (GHRH) by a selective GHRH antagonist. 38
9024267 1997
86
Spectrum of pituitary disease in multiple endocrine neoplasia type 1 (MEN 1): clinical, biochemical, and radiological features of pituitary disease in a large MEN 1 kindred. 38
8675591 1996
87
Protein kinase C-dependent growth hormone releasing peptides stimulate cyclic adenosine 3',5'-monophosphate production by human pituitary somatotropinomas expressing gsp oncogenes: evidence for crosstalk between transduction pathways. 38
8721987 1996
88
Biochemical characteristics of human pituitary somatotropinomas with and without gsp mutations: in vitro cell culture studies. 38
7608258 1995
89
Effects of bromocriptine on staining indices of Ki-67 and proliferating cell nuclear antigen, and nucleolar organizer region number in pituitary adenomas. 38
7596464 1995
90
Ossified somatotropinoma. 38
8115952 1994
91
Regulation of growth hormone secretion and messenger ribonucleic acid accumulation in human somatotropinoma cells in vitro. 38
2778032 1989
92
[Dopaminergic regulation of the hypothalamo-hypophyseal system in patients with hypophyseal adenomas]. 38
2587520 1989
93
[Growth hormone-releasing factor (GRF) stimulation test in the diagnosis of pituitary adenomas]. 38
3151885 1988
94
Biphasic effects of dexamethasone on growth hormone release in vitro. 38
2836185 1987
95
Glucocorticoid modulation of growth hormone secretion in vitro. Evidence for a biphasic effect on GH-releasing hormone mediated release. 38
3107294 1987
96
Pituitary tumors secreting growth hormone and prolactin. 38
3524338 1986
97
Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin. 38
3889029 1985

Variations for Hormone Producing Pituitary Cancer

Expression for Hormone Producing Pituitary Cancer

Search GEO for disease gene expression data for Hormone Producing Pituitary Cancer.

Pathways for Hormone Producing Pituitary Cancer

Pathways related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

(showing 14, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 SSTR5 SSTR2 SSTR1 SST PRKAR1A MEN1
2
Show member pathways
13.2 SSTR5 SSTR2 SSTR1 SST GNAS
3
Show member pathways
12.2 PRKAR1A IGF1 GNAS
4
Show member pathways
11.87 PRKAR1A IGF1 GNAS
5
Show member pathways
11.65 SSTR2 SST GNAS
6 11.59 SSTR5 SSTR2 SSTR1 GNAS
7 11.36 PRKAR1A IGF1 GNAS
8 11.31 IGF1 GNAS
9 11.17 IGF1 GNAS
10 11.13 SSTR2 SSTR1 SST PRKAR1A
11 11.12 SSTR2 GNAS
12 11 PRKAR1A GNAS
13 10.99 PRKAR1A IGF1 GNAS
14 10.68 PRKAR1A GNAS

GO Terms for Hormone Producing Pituitary Cancer

Biological processes related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

(showing 13, show less)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.72 SSTR5 SSTR2 SSTR1 SST GNAS
2 positive regulation of osteoblast differentiation GO:0045669 9.52 IGF1 GNAS
3 response to heat GO:0009408 9.51 SST IGF1
4 cerebellum development GO:0021549 9.49 SSTR2 SSTR1
5 response to starvation GO:0042594 9.48 SSTR2 SSTR1
6 cellular response to estradiol stimulus GO:0071392 9.46 SSTR2 SSTR1
7 renal water homeostasis GO:0003091 9.43 PRKAR1A GNAS
8 neuropeptide signaling pathway GO:0007218 9.43 SSTR5 SSTR2 SSTR1
9 cellular response to glucagon stimulus GO:0071377 9.4 PRKAR1A GNAS
10 cellular response to glucocorticoid stimulus GO:0071385 9.37 SSTR5 SSTR2
11 negative regulation of cell proliferation GO:0008285 9.35 SSTR5 SSTR2 SSTR1 SST MEN1
12 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.33 SSTR5 SSTR2 SSTR1
13 somatostatin signaling pathway GO:0038170 8.8 SSTR5 SSTR2 SSTR1

Molecular functions related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 9.16 IGF1 GNAS
2 neuropeptide binding GO:0042923 9.13 SSTR5 SSTR2 SSTR1
3 somatostatin receptor activity GO:0004994 8.8 SSTR5 SSTR2 SSTR1

Sources for Hormone Producing Pituitary Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
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73 UMLS via Orphanet
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