MCID: HRM003
MIFTS: 36

Hormone Producing Pituitary Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Hormone Producing Pituitary Cancer

MalaCards integrated aliases for Hormone Producing Pituitary Cancer:

Name: Hormone Producing Pituitary Cancer 12 15
Growth Hormone-Producing Pituitary Gland Neoplasm 74
Growth Hormone Producing Pituitary Tumor 12
Pituitary Tumors, Hormone Producing 12
Somatotropinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5716
NCIt 51 C7047 C7911

Summaries for Hormone Producing Pituitary Cancer

MalaCards based summary : Hormone Producing Pituitary Cancer, also known as growth hormone-producing pituitary gland neoplasm, is related to pituitary adenoma 1, multiple types and pituitary adenoma. An important gene associated with Hormone Producing Pituitary Cancer is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Development Dopamine D2 receptor transactivation of EGFR and Development Ligand-independent activation of ESR1 and ESR2. The drugs Somatostatin and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and pancreas, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Hormone Producing Pituitary Cancer

Diseases related to Hormone Producing Pituitary Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 64, show less)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 1, multiple types 32.8 AIP IGF1 SST
2 pituitary adenoma 30.5 AIP GNAS
3 pituitary tumors 29.4 AIP GNAS IGF1 MEN1 SST
4 adenoma 29.1 AIP GNAS IGF1 MEN1 SST
5 acromegaly 29.0 AIP GNAS IGF1 MEN1 SST
6 pituitary adenoma 2, growth hormone-secreting 11.1
7 malignant growth hormone secreting neoplasm of pituitary 11.1
8 silent pituitary adenoma 10.2 AIP MEN1
9 null pituitary adenoma 10.2 AIP MEN1
10 pancreatic somatostatinoma 10.2 MEN1 SST
11 carcinoid tumors, intestinal 10.1 MEN1 SST
12 pancreatic cholera 10.1 MEN1 SST
13 duodenal gastrinoma 10.1 MEN1 SST
14 gastrinoma 10.1 MEN1 SST
15 functioning pituitary adenoma 10.1 MEN1 SST
16 zollinger-ellison syndrome 10.1 MEN1 SST
17 pancreatic cystadenoma 10.1 MEN1 SST
18 duodenum cancer 10.1 MEN1 SST
19 ectopic cushing syndrome 10.1 MEN1 SST
20 villous adenoma 10.1 GNAS SST
21 islet cell tumor 10.1 MEN1 SST
22 gastrointestinal system benign neoplasm 10.1 MEN1 SST
23 acroleukopathy, symmetric 10.1
24 paraganglioma 10.1
25 serotonin syndrome 10.1 MEN1 SST
26 pseudohypoparathyroidism, type ia 10.1 GNAS IGF1
27 small intestine cancer 10.1 MEN1 SST
28 acidophil adenoma 10.0 IGF1 SST
29 pituitary infarct 10.0 IGF1 SST
30 hyperinsulinemic hypoglycemia 10.0 MEN1 SST
31 multiple endocrine neoplasia 10.0 MEN1 PRKAR1A
32 endocrine pancreas disease 10.0 IGF1 SST
33 pancreas disease 10.0 IGF1 SST
34 smith-magenis syndrome 10.0
35 isolated growth hormone deficiency, type ii 10.0 IGF1 SST
36 pseudopseudohypoparathyroidism 9.9 GNAS PRKAR1A
37 acrodysostosis 9.9 GNAS PRKAR1A
38 albright's hereditary osteodystrophy 9.9 GNAS PRKAR1A
39 short bowel syndrome 9.9 IGF1 SST
40 lipomatosis 9.9 MEN1 PRKAR1A
41 endocrine gland cancer 9.9 GNAS MEN1 SST
42 hyperprolactinemia 9.9 IGF1 SST
43 adrenal cortex disease 9.9 PRKAR1A SST
44 hypocalcemia, autosomal dominant 1 9.9 GNAS PRKAR1A
45 glucose metabolism disease 9.9 IGF1 SST
46 adrenal gland disease 9.8 PRKAR1A SST
47 hyperpituitarism 9.8 AIP IGF1 SST
48 primary pigmented nodular adrenocortical disease 9.8 GNAS PRKAR1A
49 hyperthyroidism 9.8 GNAS SST
50 carcinoid syndrome 9.8 IGF1 MEN1 SST
51 acquired metabolic disease 9.8 IGF1 SST
52 autosomal genetic disease 9.8 MEN1 PRKAR1A
53 multiple endocrine neoplasia, type iv 9.8 AIP MEN1 PRKAR1A
54 mccune-albright syndrome 9.8 GNAS IGF1 SST
55 fibrous dysplasia 9.8 GNAS IGF1 SST
56 microvascular complications of diabetes 1 9.6 IGF1 SST
57 endocrine organ benign neoplasm 9.6 AIP IGF1 MEN1 SST
58 pituitary gland disease 9.6 AIP IGF1 MEN1 SST
59 carney complex variant 9.5 AIP GNAS MEN1 PRKAR1A
60 growth hormone secreting pituitary adenoma 9.5 AIP GNAS PRKAR1A SST
61 multiple endocrine neoplasia, type i 9.4 GNAS MEN1 PRKAR1A SST
62 conn's syndrome 9.4 GNAS MEN1 PRKAR1A SST
63 cell type benign neoplasm 9.3 AIP GNAS IGF1 MEN1 SST
64 pituitary adenoma, prolactin-secreting 8.9 AIP GNAS IGF1 MEN1 PRKAR1A SST

Graphical network of the top 20 diseases related to Hormone Producing Pituitary Cancer:



Diseases related to Hormone Producing Pituitary Cancer

Symptoms & Phenotypes for Hormone Producing Pituitary Cancer

MGI Mouse Phenotypes related to Hormone Producing Pituitary Cancer:

47 (showing 6, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 AIP GNAS IGF1 MEN1 PRKAR1A
2 growth/size/body region MP:0005378 9.73 AIP GNAS IGF1 MEN1 PRKAR1A SST
3 endocrine/exocrine gland MP:0005379 9.72 AIP GNAS IGF1 MEN1 PRKAR1A
4 homeostasis/metabolism MP:0005376 9.63 AIP GNAS IGF1 MEN1 PRKAR1A SST
5 liver/biliary system MP:0005370 9.26 AIP GNAS MEN1 PRKAR1A
6 neoplasm MP:0002006 9.02 AIP GNAS IGF1 MEN1 PRKAR1A

Drugs & Therapeutics for Hormone Producing Pituitary Cancer

Drugs for Hormone Producing Pituitary Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 13, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 3,Phase 1 38916-34-6, 51110-01-1 53481605
2
lanreotide Approved Phase 3 108736-35-2
3 Hormones Phase 3,Phase 2,Phase 1
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
5 Hormone Antagonists Phase 3
6 Pharmaceutical Solutions Phase 3
7 Angiopeptin Phase 3
8
Octreotide Approved, Investigational Phase 1 83150-76-9 6400441 383414
9 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
10 Antineoplastic Agents, Hormonal Phase 1
11 Gastrointestinal Agents Phase 1
12 Radiopharmaceuticals Phase 1
13 Edotreotide Phase 1

Interventional clinical trials:

(showing 7, show less)
# Name Status NCT ID Phase Drugs
1 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
2 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
3 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
4 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
5 The Observational Study of Growth Hormone-secreting Pituitary Tumors Unknown status NCT01368133
6 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
7 Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA Recruiting NCT00461188

Search NIH Clinical Center for Hormone Producing Pituitary Cancer

Genetic Tests for Hormone Producing Pituitary Cancer

Anatomical Context for Hormone Producing Pituitary Cancer

MalaCards organs/tissues related to Hormone Producing Pituitary Cancer:

42
Pituitary, Brain, Pancreas, Small Intestine, Cortex, Adrenal Cortex, Adrenal Gland

Publications for Hormone Producing Pituitary Cancer

Articles related to Hormone Producing Pituitary Cancer:

(showing 3, show less)
# Title Authors Year
1
Unusual type of growth hormone-producing pituitary tumor in acromegaly. ( 22638653 )
2012
2
Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH? ( 22170724 )
2012
3
Shrinking of a growth hormone-producing pituitary tumor by continuous subcutaneous infusion of the somatostatin analog SMS 201-995. ( 2889748 )
1987

Variations for Hormone Producing Pituitary Cancer

Expression for Hormone Producing Pituitary Cancer

Search GEO for disease gene expression data for Hormone Producing Pituitary Cancer.

Pathways for Hormone Producing Pituitary Cancer

GO Terms for Hormone Producing Pituitary Cancer

Biological processes related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of osteoblast differentiation GO:0045669 9.26 GNAS IGF1
2 response to heat GO:0009408 9.16 IGF1 SST
3 renal water homeostasis GO:0003091 8.96 GNAS PRKAR1A
4 cellular response to glucagon stimulus GO:0071377 8.62 GNAS PRKAR1A

Molecular functions related to Hormone Producing Pituitary Cancer according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.62 GNAS IGF1

Sources for Hormone Producing Pituitary Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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