MCID: HRN001
MIFTS: 46

Horner's Syndrome

Categories: Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Horner's Syndrome

MalaCards integrated aliases for Horner's Syndrome:

Name: Horner's Syndrome 12 76 53 25 15
Horner Syndrome 12 25 44 73
Bernard-Horner Syndrome 53 25
Oculosympathetic Palsy 53 25
Cervical Sympathetic Paralysis 12
Cervical Sympathetic Dystrophy 73
Bernard Horner Syndrome 12
Von Passow Syndrome 25

Classifications:



External Ids:

Disease Ontology 12 DOID:11486
ICD10 33 G90.2
MeSH 44 D006732
NCIt 50 C28155

Summaries for Horner's Syndrome

NIH Rare Diseases : 53 Horner's syndromeis a rare condition characterized by miosis (constriction of the pupil), ptosis (drooping of the upper eyelid), and anhidrosis (absence of sweating of the face). It is caused by damage to the sympathetic nerves of the face. The underlying causes of Horner's syndrome vary greatly and may include a tumor, stroke, or other damage to a part of the brain called the brain stem; injury to the carotid artery; and trauma to the brachial plexus. In rare cases, Horner's syndrome is congenital (present from birth) and associated with a lack of pigmentation of the iris (colored part of the eye). Treatment of Horner's syndrome depends on the underlying cause.

MalaCards based summary : Horner's Syndrome, also known as horner syndrome, is related to horner syndrome, congenital and breast rhabdomyosarcoma. An important gene associated with Horner's Syndrome is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways is Sympathetic Nerve Pathway (Neuroeffector Junction). The drugs Ropivacaine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are Decreased viability in esophageal squamous lineage and Decreased HPV16-GFP infection

Genetics Home Reference : 25 Horner syndrome is a disorder that affects the eye and surrounding tissues on one side of the face and results from paralysis of certain nerves. Horner syndrome can appear at any time of life; in about 5 percent of affected individuals, the disorder is present from birth (congenital).

Wikipedia : 76 Horner\'s syndrome is a combination of symptoms that arises when a group of nerves known as the... more...

Related Diseases for Horner's Syndrome

Graphical network of the top 20 diseases related to Horner's Syndrome:



Diseases related to Horner's Syndrome

Symptoms & Phenotypes for Horner's Syndrome

GenomeRNAi Phenotypes related to Horner's Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.17 ADRA1A ADRA2A AP4S1 CD6 DES KRT7
2 Decreased HPV16-GFP infection GR00350-A 9.13 ADRA1A DES MYOD1

MGI Mouse Phenotypes related to Horner's Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 ADRA1A ADRA2A AP4E1 CD6 DES KRT7

Drugs & Therapeutics for Horner's Syndrome

Drugs for Horner's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
2
Epinephrine Approved, Vet_approved Phase 4,Phase 1,Phase 2 51-43-4 5816
3
Mepivacaine Approved, Vet_approved Phase 4,Not Applicable 96-88-8 4062
4
Racepinephrine Approved Phase 4,Phase 1,Phase 2 329-65-7 838
5
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
6
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 137-58-6 3676
7
Bupivacaine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
8 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Anesthetics, Local Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Epinephryl borate Phase 4,Phase 1,Phase 2
13 Chlorhexidine gluconate Phase 4
14 Pharmaceutical Solutions Phase 4
15
Atracurium Approved, Experimental, Investigational Phase 1, Phase 2 64228-79-1 47319
16
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 1, Phase 2 437-38-7 3345
17
Ketamine Approved, Vet_approved Phase 1, Phase 2,Not Applicable 6740-88-1 3821
18
Midazolam Approved, Illicit Phase 1, Phase 2,Not Applicable 59467-70-8 4192
19
Propofol Approved, Investigational, Vet_approved Phase 1, Phase 2 2078-54-8 4943
20
Sevoflurane Approved, Vet_approved Phase 1, Phase 2 28523-86-6 5206
21
Carvedilol Approved, Investigational Phase 2 72956-09-3 2585
22
Enalapril Approved, Vet_approved Phase 2 75847-73-3 5362032 40466924
23
Enalaprilat Approved Phase 2 76420-72-9 6917719
24
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
25 Adjuvants, Anesthesia Phase 1, Phase 2,Not Applicable
26 Adrenergic Agents Phase 1, Phase 2
27 Adrenergic Agonists Phase 1, Phase 2
28 Adrenergic alpha-Agonists Phase 1, Phase 2
29 Adrenergic beta-Agonists Phase 1, Phase 2
30 Analgesics Phase 1, Phase 2,Not Applicable
31 Analgesics, Opioid Phase 1, Phase 2
32 Anesthetics, Dissociative Phase 1, Phase 2,Not Applicable
33 Anesthetics, General Phase 1, Phase 2,Not Applicable
34 Anesthetics, Inhalation Phase 1, Phase 2
35 Anesthetics, Intravenous Phase 1, Phase 2,Not Applicable
36 Anti-Anxiety Agents Phase 1, Phase 2,Not Applicable
37 Anti-Arrhythmia Agents Phase 1, Phase 2,Not Applicable
38 Anti-Asthmatic Agents Phase 1, Phase 2
39 Autonomic Agents Phase 1, Phase 2
40 Bronchodilator Agents Phase 1, Phase 2
41 Cholinergic Agents Phase 1, Phase 2
42 Cholinergic Antagonists Phase 1, Phase 2
43 Diuretics, Potassium Sparing Phase 1, Phase 2,Not Applicable
44 Excitatory Amino Acid Antagonists Phase 1, Phase 2,Not Applicable
45 Excitatory Amino Acids Phase 1, Phase 2,Not Applicable
46 GABA Agents Phase 1, Phase 2,Not Applicable
47 GABA Modulators Phase 1, Phase 2,Not Applicable
48 Hypnotics and Sedatives Phase 1, Phase 2,Not Applicable
49 Mydriatics Phase 1, Phase 2
50 Narcotics Phase 1, Phase 2

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Determining the Minimal Effective Volume (MEAV95) for Interscalene Brachial Plexus Block for Surgical Anesthesia Unknown status NCT01703130 Phase 4
2 The Retroclavicular Approach for Regional Anesthesia of the Upper Limb in Obese Patients Completed NCT02086643 Phase 4
3 Suprascapular and Axillary Blocks Versus Interscalene Block for Shoulder Surgery Completed NCT02517437 Phase 4 Suprascapular & axillary blocks;Interscalene block
4 Comparative Study Between Single , Intra- Cluster and Double-injection Ultrasound-guided Supraclavicular Block of Brachial Plexus Enrolling by invitation NCT03188939 Phase 4
5 Does a Low Volume Ultrasound-Guided Technique Reduce Common Complications of Interscalene Brachial Plexus Block? Completed NCT00497354 Phase 3 Variation in volume of local anesthetic
6 Three-level Injection Paravertebral Block vs General Anesthesia in Mastectomy Completed NCT02065947 Phase 1, Phase 2 fentanyl, propofol, atracurium;lidocaine , adrenaline, ketamine bolus, midazolam;sevoflurane and 50% oxygen in air
7 Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study Recruiting NCT03071653 Phase 2
8 Surgical Sympathetic Blockade in Heart Failure Completed NCT01224899 Phase 1
9 Horner's SD After Thoracic Epidural Block Completed NCT02130739 Ropivacaine;Propofol;Fentanyl
10 Clinical Efficacy of Supraclavicular Block for Arthroscopic Shoulder Surgery Completed NCT01958801 Not Applicable
11 Predictive Factors for Hypotensive Bradycardic Events During Arthroscopic Shoulder Surgery Completed NCT01926561
12 Posterior Parasagittal In-Plane Ultrasound-Guided Infraclavicular Brachial Plexus Block Completed NCT02312453 Not Applicable
13 Conventional Versus Posterior Approach in Ultrasound-Guided Parasagittal In-Plane Infraclavicular Brachial Plexus Block Completed NCT02462408 Not Applicable
14 Ultrasound Guided Axillary Brachial Plexus Block Versus Supraclavicular Block in Emergency Crushed Hand Patients Completed NCT03377985 Not Applicable
15 Ultrasound-guided Intermediate Cervical Plexus Block Completed NCT02794974 Not Applicable
16 Anterior Ultrasound-guided Cervical Plexus Block for Carotid Endarterectomy Completed NCT01640613
17 Distance for Interscalene Block Completed NCT01568463
18 Retroclavicular Approach vs Infraclavicular Approach for Plexic Bloc Anesthesia of the Upper Limb Completed NCT02913625 Not Applicable
19 Pupillometry in Horner's Syndrome Recruiting NCT02978079 Not Applicable
20 The Effects of Horner's Syndrome Developing After Interscalene Brachial Plexus Block on Autonomic Nervous Activity Recruiting NCT03514342 0.75% ropivacaine
21 Interscalene vs Anterior and Posterior Suprascapular Nerve Block for Shoulder Arthroscopic Surgeries Recruiting NCT03277326 Not Applicable
22 Continuous Blockade of the Brachial Plexus Recruiting NCT02769429
23 Efficacy of the C8 Nerve Root Block During Interscalene Block for Anesthesia of the Posterior Aspect of the Shoulder Recruiting NCT03487874 Not Applicable 0.75% ropivacaine
24 Chemical Block and Electrical Stimulation of the Carotid Body to Treat Refractory Hypertension Recruiting NCT02519868 Not Applicable
25 Comparison of US-Guided Paravertebral and Proximal Intercostal Nerve Blocks Recruiting NCT02911168 Not Applicable
26 Dexamethasone at Lower Concentration Ropivacaine in the Supraclavicular Nerve Block Enrolling by invitation NCT03572686 Not Applicable Ropivacaine 0.5% 20mL;Ropivacaine 0.25% 20ml;Ropivacaine 0.25% 20ml + dexamethasone 8mg
27 Comparison of Erector Spinae Plane Block With Serratus Anterior Plane Block for Breast Surgery Not yet recruiting NCT03579524 Not Applicable
28 Programmed Intermittent Bolus for Infusion of Local Anesthetic During Continuous Interscalene Nerve Blockade for Total Shoulder Arthroplasty: a Randomized Controlled Trial Not yet recruiting NCT03268837 Not Applicable
29 Comparison of Volumes of Local Anesthetics on the Efficiency and Safety of Stellate Ganglion Block for CRPS of the Arm Not yet recruiting NCT03316066 Not Applicable
30 Interscalene Nerve Block vs. Sedation for Shoulder Dislocation Reduction Not yet recruiting NCT03041506 Not Applicable Lidocaine;Midazolam;Ketamine
31 Clinical Evaluation of the Ultrasound-Guided Retroclavicular Brachial Plexus Block Withdrawn NCT01605929 Not Applicable

Search NIH Clinical Center for Horner's Syndrome

Cochrane evidence based reviews: horner syndrome

Genetic Tests for Horner's Syndrome

Anatomical Context for Horner's Syndrome

MalaCards organs/tissues related to Horner's Syndrome:

41
Eye, Brain, Testes, Thyroid, Heart, Tongue, B Cells

Publications for Horner's Syndrome

Articles related to Horner's Syndrome:

(show top 50) (show all 552)
# Title Authors Year
1
Horner's syndrome following obstetric neuraxial blockade - a systematic review of the literature. ( 29657082 )
2018
2
A case of Horner's syndrome after catheter-based fibrinolysis for pulmonary embolism. ( 29775165 )
2018
3
Cervical Sympathetic Chain Schwannoma Masquerading as a Vagus Nerve Schwannoma Complicated by Postoperative Horner's Syndrome and Facial Pain: A Case Report. ( 29908450 )
2018
4
Risk factors for the development of Horner's syndrome following interscalene brachial plexus block using ropivacaine for shoulder arthroscopy: a randomised trial. ( 29931665 )
2018
5
Dramatic extremity temperature increase and Horner's syndrome after stellate ganglion block. ( 29343589 )
2018
6
Unilateral Straight Hair-A Symptom of Acquired Horner's Syndrome in a Neonate. ( 29632800 )
2018
7
Cervical Arteriovenous Malformation Causing Horner's Syndrome. ( 28219497 )
2017
8
Horner's syndrome in cervico-dorsal tuberculosis: A rare case report. ( 28720996 )
2017
9
Unusual Horner's Syndrome in Recurrent Breast Cancer: Evaluation Using (18)F-FDG PET/CT. ( 28250864 )
2017
10
Rare Complications of Cervical Spine Surgery: Horner's Syndrome. ( 28451480 )
2017
11
Left parapharyngeal ectopic goitre associated with eutopic thyroid and postoperative Horner's syndrome. ( 28215490 )
2017
12
Metastatic testicular cancer, a Horner's syndrome and brachial plexopathy. ( 28472531 )
2017
13
Backpack palsy with Horner's syndrome. ( 28536218 )
2017
14
[Horner's Syndrome: an unusual ophthalmological presentation of Hodgkin lymphoma]. ( 29215661 )
2017
15
Rhabdomyolysis resulting in concurrent Horner's syndrome and brachial plexopathy: a case report. ( 28321484 )
2017
16
A Ruptured Extra-dural Spinal Arterio-venous Malformation Presenting as Horner's Syndrome: The First Case Report. ( 29142793 )
2017
17
Spontaneous cervical intradural disc herniation presenting with Brown-SAcquard and Horner's syndrome: lesson learned from a very unique case. ( 28343313 )
2017
18
Iatrogenic Horner's syndrome: A cause for diagnostic confusion in the emergency department. ( 28680524 )
2017
19
Hemodynamic instability and Horner's syndrome following a labour lumbar neuraxial block: A warning sign of a potentially lethal event? ( 28116954 )
2017
20
Horner's Syndrome in a Case of Granulocytic Sarcoma. ( 28596669 )
2017
21
Post-thyroidectomy iatrogenic Horner's syndrome with heterochromia. ( 27239603 )
2016
22
Uncommon cause of Horner's syndrome. ( 27566214 )
2016
23
Heralding Extramedullary Blast Crisis: Horner's Syndrome with Brachial Plexopathy in a Patient with Chronic Myelogenous Leukemia. ( 28096817 )
2016
24
Horner's Syndrome after Scalene Block and Carotid Dissection. ( 26899514 )
2016
25
Horner's syndrome: an unusual complication of thyroidectomy: a case report. ( 27784321 )
2016
26
Horner's Syndrome due to a Spontaneous Internal Carotid Artery Dissection after Deep Sea Scuba Diving. ( 27525139 )
2016
27
A rare presentation of spontaneous internal carotid artery dissection with Horner's syndrome, VIIth, Xth and XIIth nerve palsies. ( 27699055 )
2016
28
Horner's Syndrome Incidental to Medullary Thyroid Carcinoma Excision: Case Report and Brief Literature Review. ( 27200201 )
2016
29
Unique Case of Pseudomembranous Aspergillus Tracheobronchitis: Tracheal Perforation and Horner's Syndrome. ( 27255521 )
2016
30
Horner's syndrome: An unusual presentation of metastatic disease in breast cancer. ( 26405267 )
2015
31
Osteochondroma of the clavicle causing Horner's syndrome. ( 26385940 )
2015
32
Horner's syndrome subsequent to minimally invasive video-assisted thyroidectomy in two patients. ( 26171051 )
2015
33
Horner's Syndrome after Superficial Cervical Plexus Block. ( 25987922 )
2015
34
Minor's Test: Objective Demonstration of Horner's Syndrome. ( 26075177 )
2015
35
First Rib Fracture Resulting in Horner's Syndrome. ( 26375810 )
2015
36
Horner's syndrome in a patient presenting with chest pain. ( 26228195 )
2015
37
Erythema migrans associated with partial Horner's syndrome. ( 26643187 )
2015
38
Brown-SAcquard syndrome without vascular injury associated with Horner's syndrome after a stab injury to the neck. ( 25659820 )
2015
39
Transient Horner's syndrome following thoracic epidural anesthesia for mastectomy: a prospective observational study. ( 25560203 )
2015
40
Granular cell tumor of the stellate ganglion presenting with Horner's syndrome. ( 26094560 )
2015
41
A Case of Mediastinal Granular Cell Tumor with Horner's Syndrome. ( 26041255 )
2015
42
Horner's syndrome in patients admitted to the intensive care unit that have undergone central venous catheterization: a prospective study. ( 26381100 )
2015
43
Horner's Syndrome Secondary to Epidural Anaesthesia Following Posterior Instrumented Scoliosis Correction. ( 25705345 )
2015
44
Horner's syndrome due to cervical myelopathy. ( 25341945 )
2014
45
Horner's syndrome secondary to intervertebral disc herniation at the level of T1-2. ( 24903729 )
2014
46
Horner's syndrome after paediatric cardiac surgery: case report and review of the literature. ( 24717921 )
2014
47
Visual Hallucinations in a Patient with Horner's Syndrome Secondary to Internal Carotid Dissection. ( 25473403 )
2014
48
Rapidly enlarging neck masses of the thyroid with Horner's syndrome: A concise clinical review. ( 25073932 )
2014
49
Horner's Syndrome: A Case Report and Review of Pathophysiology and Clinical Features. ( 25314289 )
2014
50
Congenital lingual hemihyperplasia, Horner's syndrome, and agenesis of the internal carotid artery. ( 24938148 )
2014

Variations for Horner's Syndrome

Expression for Horner's Syndrome

Search GEO for disease gene expression data for Horner's Syndrome.

Pathways for Horner's Syndrome

Pathways related to Horner's Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.98 ADRA1A ADRA2A

GO Terms for Horner's Syndrome

Cellular components related to Horner's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.16 AP4E1 AP4S1
2 endosome lumen GO:0031904 8.96 AP4E1 AP4S1
3 AP-4 adaptor complex GO:0030124 8.62 AP4E1 AP4S1

Biological processes related to Horner's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein localization GO:0008104 9.37 AP4E1 AP4S1
2 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 9.32 ADRA1A ADRA2A
3 protein targeting GO:0006605 9.26 AP4E1 AP4S1
4 regulation of vasoconstriction GO:0019229 9.16 ADRA1A ADRA2A
5 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 8.96 ADRA1A ADRA2A
6 adrenergic receptor signaling pathway GO:0071875 8.62 ADRA1A ADRA2A

Molecular functions related to Horner's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adrenergic receptor activity GO:0004935 8.62 ADRA1A ADRA2A

Sources for Horner's Syndrome

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