MCID: HTL001
MIFTS: 35

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards integrated aliases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

Name: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis 54
Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/tropical Spastic Paraparesis 54
Tropical Spastic Paraparesis 74
Ham/tsp 54

Classifications:



External Ids:

UMLS 74 C0030481

Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

NIH Rare Diseases : 54 HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the nervous system that affects less than 2% of people with HTLV-1 infection. Signs and symptoms vary but may include slowly progressive weakness and spasticity of one or both legs, exaggerated reflexes, muscle contractions in the ankle, and lower back pain. Other features may include urinary incontinence and minor sensory changes, especially burning or prickling sensations and loss of vibration sense. The reason some people with HTLV-1 infection develop HAM/TSTP is not well understood. Treatment generally aims to control the specific symptoms, as there is no standard treatment available.Interferon alpha may be beneficial over short periods, and some aspects of the disease may be improved with interferon beta. Other medications may include immune globulin, oral corticosteroids, and muscle relaxers such as baclofen or tizanidine.

MalaCards based summary : Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as human t-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis, is related to tropical spastic paraparesis and hashimoto thyroiditis. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is IFNL3 (Interferon Lambda 3), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and IL12-mediated signaling events. The drugs Miconazole and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and thyroid.

Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 32.8 CXCR3 IFNG IFNL3
2 hashimoto thyroiditis 30.1 CXCR3 IFNG
3 myelopathy, htlv-1-associated 12.1
4 human t-cell leukemia virus type 1 12.0
5 retrovirus-associated myelopathy 11.7
6 spastic paraparesis 11.1
7 leukemia 10.6
8 t-cell leukemia 10.6
9 dermatitis 10.6
10 infective dermatitis associated with htlv-1 10.6
11 adult t-cell leukemia 10.5
12 neurogenic bladder 10.3
13 myelitis 10.3
14 multiple sclerosis 10.3
15 muscle disorders 10.3
16 lymphoma 10.3
17 myopathy 10.3
18 peripheral nervous system disease 10.3
19 neuropathy 10.3
20 amyotrophic lateral sclerosis 1 10.2
21 osteoporosis 10.2
22 pseudopseudohypoparathyroidism 10.2
23 meningoencephalitis 10.2
24 strongyloidiasis 10.2
25 lateral sclerosis 10.2
26 thyroiditis 10.2
27 extrinsic allergic alveolitis 10.2
28 pain - chronic 10.2
29 spasticity 10.2
30 cryoglobulinemia 10.1 CXCR3 IFNL3
31 chromoblastomycosis 10.1 CXCR3 HLA-A
32 idiopathic bronchiectasis 10.0 HLA-A IFNG
33 histoplasmosis 10.0 HLA-A IFNG
34 intermediate uveitis 10.0 CXCR3 IFNG
35 uveitis 10.0 CXCR3 IFNG
36 orofacial granulomatosis 10.0 CXCR3 IFNG
37 cytomegalovirus retinitis 10.0 HLA-A IFNG
38 nonspecific interstitial pneumonia 10.0 CXCR3 IFNG
39 lichen disease 10.0 CXCR3 IFNG
40 erythema multiforme 10.0 CXCR3 IFNG
41 hematopoietic stem cell transplantation 10.0 HLA-A IFNG
42 proliferative glomerulonephritis 10.0 CXCR3 IFNG
43 spondyloarthropathy 10.0 HLA-A IFNG
44 herpes zoster 10.0 HLA-A IFNG
45 bronchiolitis obliterans 10.0 CXCR3 IFNG
46 secondary progressive multiple sclerosis 10.0 CXCR3 IFNG
47 dengue hemorrhagic fever 10.0 HLA-A IFNG
48 pulmonary sarcoidosis 10.0 CXCR3 IFNG
49 autoimmune disease of central nervous system 10.0 CXCR3 IFNG
50 allergic contact dermatitis 10.0 CXCR3 IFNG

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Symptoms & Phenotypes for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
2
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
3
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
4
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
5 Dermatologic Agents Phase 2, Phase 3
6 Cyclosporins Phase 2, Phase 3
7 Antifungal Agents Phase 2, Phase 3
8 Immunologic Factors Phase 2, Phase 3
9 Calcineurin Inhibitors Phase 2, Phase 3
10 Immunosuppressive Agents Phase 2, Phase 3
11 Antirheumatic Agents Phase 2, Phase 3
12 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Early Phase 1
13 Protective Agents Phase 3
14 Radiation-Protective Agents Phase 3
15 Free Radical Scavengers Phase 3
16 Antioxidants Phase 3
17 Vasodilator Agents Phase 3
18 Platelet Aggregation Inhibitors Phase 3
19 Phosphodiesterase Inhibitors Phase 3
20 Antiviral Agents Phase 2, Phase 3,Early Phase 1
21 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
22 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
23 Reverse Transcriptase Inhibitors Phase 2, Phase 3
24 Antimetabolites Phase 2, Phase 3
25 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
26
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
27
Infliximab Approved Phase 2 170277-31-3
28 Adjuvants, Immunologic Phase 2
29 interferons Phase 2
30 Interferon-beta Phase 2
31 Gastrointestinal Agents Phase 2
32 Antibodies, Monoclonal Phase 1
33 Immunoglobulins Phase 1
34 Antibodies Phase 1
35
Valproic Acid Approved, Investigational Not Applicable 99-66-1 3121
36 Integrase Inhibitors Early Phase 1
37 Raltegravir Potassium Early Phase 1
38 HIV Integrase Inhibitors Early Phase 1
39 Central Nervous System Depressants Not Applicable
40 Neurotransmitter Agents Not Applicable
41 Tranquilizing Agents Not Applicable
42 Psychotropic Drugs Not Applicable
43 Antimanic Agents Not Applicable
44 GABA Agents Not Applicable
45 Anticonvulsants Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
2 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
3 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
4 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
5 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
6 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
7 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
8 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
9 Raltegravir for HAM/TSP Completed NCT01867320 Early Phase 1 Raltegravir
10 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
11 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Completed NCT01651819 Not Applicable
12 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
13 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
14 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Not Applicable Valproic Acid

Search NIH Clinical Center for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

42
T Cells, Brain, Thyroid, Spinal Cord, Prostate, Thymus, Nk Cells

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Articles related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

(show top 50) (show all 99)
# Title Authors Year
1
Curcumin increased the expression of c-FLIP in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 31074052 )
2019
2
Functional capacity of natural killer cells in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 31101076 )
2019
3
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2018
4
Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 30341468 )
2018
5
Role of Integrin Signaling Activation on the Development of Human T Cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-Infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
6
Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010). ( 29554087 )
2018
7
Proposal of Classification Criteria for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Disease Activity. ( 30090093 )
2018
8
Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil. ( 30466392 )
2018
9
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
10
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
11
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
12
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
13
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
14
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-γ, and TNF-α in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
15
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
16
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
17
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2016
18
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
19
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
20
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8+ T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
21
HTLV-1-associated myelopathy/tropical spastic paraparesis and peripheral neuropathy following live-donor renal transplantation. ( 25196582 )
2015
22
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
23
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
24
Editorial Commentary: Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
25
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
26
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
27
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
28
Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
29
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
30
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015
31
HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 27188208 )
2015
32
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
33
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24802839 )
2014
34
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25227931 )
2014
35
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. ( 25229227 )
2014
36
IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers. ( 25233462 )
2014
37
Neuroimmunological aspects of human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis. ( 23943469 )
2014
38
Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. ( 24041428 )
2014
39
Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease. ( 23924924 )
2013
40
Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 23022356 )
2013
41
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. ( 23278610 )
2013
42
Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran. ( 23568138 )
2013
43
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 23651542 )
2013
44
Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression. ( 23756056 )
2013
45
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. ( 23932323 )
2013
46
CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24130912 )
2013
47
Contribution of Galvanic Vestibular Stimulation for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 24285967 )
2013
48
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. ( 22170554 )
2012
49
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 22720101 )
2012
50
Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients. ( 22990976 )
2012

Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Expression for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Pathways related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 CD274 HLA-A
2
Show member pathways
11.21 HLA-A IFNG
3 10.86 CXCR3 IFNG
4
Show member pathways
10.41 HLA-A IFNG

GO Terms for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Cellular components related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome membrane GO:0031901 9.16 CD274 HLA-A
2 cell surface GO:0009986 9.13 CD274 CXCR3 HLA-A
3 recycling endosome membrane GO:0055038 8.62 CD274 HLA-A

Biological processes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.16 HLA-A IFNG
2 cell surface receptor signaling pathway GO:0007166 9.13 CD274 CXCR3 IFNG
3 immune response GO:0006955 8.92 CD274 CXCR3 HLA-A IFNG

Sources for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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45 MeSH
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