MCID: HTL001
MIFTS: 31

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards integrated aliases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

Name: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis 53
Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/tropical Spastic Paraparesis 53
Tropical Spastic Paraparesis 73
Ham/tsp 53

Classifications:



Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

NIH Rare Diseases : 53 HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the nervous system that affects less than 2% of people with HTLV-1 infection. Signs and symptoms vary but may include slowly progressive weakness and spasticity of one or both legs, exaggerated reflexes, muscle contractions in the ankle, and lower back pain. Other features may include urinary incontinence and minor sensory changes, especially burning or prickling sensations and loss of vibration sense. Why some people with HTLV-1 infection develop HAM/TSTP is not well understood. Treatment generally aims to control the specific symptoms, as there is no standard treatment available.Interferon alpha may be beneficial over short periods, and some aspects of the disease may be improved with interferon beta. Other medication may include immune globulin, oral corticoids and muscular relaxes such as baclofen or tizanidine.

MalaCards based summary : Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as human t-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis, is related to myelopathy, htlv-1-associated and tropical spastic paraparesis. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is HLA-A (Major Histocompatibility Complex, Class I, A), and among its related pathways/superpathways are HTLV-I infection and Epstein-Barr virus infection. The drugs Lamivudine and Zidovudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and b cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 myelopathy, htlv-1-associated 12.4
2 tropical spastic paraparesis 11.9
3 human t-cell leukemia virus type 1 11.5
4 retrovirus-associated myelopathy 11.5
5 spastic paraparesis 11.0
6 spasticity 11.0
7 leukemia 10.5
8 t-cell leukemia 10.5
9 dermatitis 10.5
10 infective dermatitis associated with htlv-1 10.5
11 adult t-cell leukemia 10.4
12 multiple sclerosis 10.2
13 lymphoma 10.2
14 myopathy 10.2
15 peripheral nervous system disease 10.2
16 neuropathy 10.2
17 autonomic dysfunction 10.2
18 hematologic cancer 9.4 HLA-A MYC
19 celiac disease 1 9.3 HLA-A KLRK1

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Symptoms & Phenotypes for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

GenomeRNAi Phenotypes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.44 HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.44 HLA-A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.44 HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.44 HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.44 HLA-A MYC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.44 HLA-A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.44 MYC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.44 MYC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.44 HLA-A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.44 HLA-A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.44 MYC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.44 HLA-A
13 Increased cell size GR00098-A-4 8.96 MYC NEFH

Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
2
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
5 Reverse Transcriptase Inhibitors Phase 2, Phase 3
6 Cyclosporins Phase 2, Phase 3
7 Dermatologic Agents Phase 2, Phase 3
8 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
9 Vasodilator Agents Phase 3
10 Phosphodiesterase Inhibitors Phase 3
11 Platelet Aggregation Inhibitors Phase 3
12 Immunosuppressive Agents Phase 2, Phase 3
13 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Early Phase 1
14 Antifungal Agents Phase 2, Phase 3
15 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
16 Antioxidants Phase 3
17 Protective Agents Phase 3
18 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
19 Radiation-Protective Agents Phase 3
20 Antirheumatic Agents Phase 2, Phase 3
21 Antimetabolites Phase 2, Phase 3
22 Antiviral Agents Phase 2, Phase 3,Early Phase 1
23 Calcineurin Inhibitors Phase 2, Phase 3
24
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
25
Infliximab Approved Phase 2 170277-31-3
26 interferons Phase 2
27 Adjuvants, Immunologic Phase 2
28 Interferon-beta Phase 2
29 Gastrointestinal Agents Phase 2
30 Antibodies Phase 1
31 Immunoglobulins Phase 1
32 Antibodies, Monoclonal Phase 1
33
Valproic Acid Approved, Investigational Not Applicable 99-66-1 3121
34 Raltegravir Potassium Early Phase 1
35 HIV Integrase Inhibitors Early Phase 1
36 Integrase Inhibitors Early Phase 1
37 Central Nervous System Depressants Not Applicable
38 GABA Agents Not Applicable
39 Neurotransmitter Agents Not Applicable
40 Tranquilizing Agents Not Applicable
41 Anticonvulsants Not Applicable
42 Psychotropic Drugs Not Applicable
43 Antimanic Agents Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
2 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
3 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
4 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
5 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
6 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
7 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
8 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Unknown status NCT01651819 Not Applicable
9 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
10 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
11 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
12 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
13 Raltegravir for HAM/TSP Active, not recruiting NCT01867320 Early Phase 1 Raltegravir
14 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Not Applicable Valproic Acid

Search NIH Clinical Center for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

41
T Cells, Brain, B Cells, Spinal Cord

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Articles related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

(show all 29)
# Title Authors Year
1
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
2
Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010). ( 29554087 )
2018
3
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
4
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
5
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
6
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
7
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
8
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25227931 )
2014
9
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. ( 23932323 )
2013
10
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. ( 23278610 )
2013
11
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 22720101 )
2012
12
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 21510232 )
2011
13
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? ( 22519224 )
2011
14
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 20169122 )
2010
15
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. ( 20572090 )
2010
16
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. ( 20851016 )
2010
17
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. ( 19578703 )
2009
18
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 19228429 )
2009
19
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? ( 19936247 )
2009
20
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. ( 17884099 )
2008
21
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. ( 17717136 )
2007
22
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. ( 17034574 )
2006
23
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 16503269 )
2006
24
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 15961107 )
2005
25
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. ( 15722539 )
2005
26
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. ( 8912212 )
1996
27
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 8555734 )
1995
28
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. ( 8372632 )
1993
29
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. ( 1736016 )
1992

Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Expression for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

GO Terms for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Biological processes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 8.62 HLA-A KLRK1

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