MCID: HTL001
MIFTS: 34

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards integrated aliases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

Name: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis 54
Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/tropical Spastic Paraparesis 54
Tropical Spastic Paraparesis 74
Ham/tsp 54

Classifications:



External Ids:

UMLS 74 C0030481

Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

NIH Rare Diseases : 54 HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the nervous system that affects less than 2% of people with HTLV-1 infection. Signs and symptoms vary but may include slowly progressive weakness and spasticity of one or both legs, exaggerated reflexes, muscle contractions in the ankle, and lower back pain. Other features may include urinary incontinence and minor sensory changes, especially burning or prickling sensations and loss of vibration sense. The reason some people with HTLV-1 infection develop HAM/TSTP is not well understood. Treatment generally aims to control the specific symptoms, as there is no standard treatment available.Interferon alpha may be beneficial over short periods, and some aspects of the disease may be improved with interferon beta. Other medications may include immune globulin, oral corticosteroids, and muscle relaxers such as baclofen or tizanidine.

MalaCards based summary : Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as human t-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis, is related to tropical spastic paraparesis and myelopathy, htlv-1-associated. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is IFNL3 (Interferon Lambda 3), and among its related pathways/superpathways is Cell adhesion molecules (CAMs). The drugs Miconazole and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord.

Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 32.6 CXCR3 FOXP3 IFNL3
2 myelopathy, htlv-1-associated 12.1
3 human t-cell leukemia virus type 1 11.7
4 retrovirus-associated myelopathy 11.7
5 spastic paraparesis 11.1
6 leukemia 10.7
7 t-cell leukemia 10.7
8 dermatitis 10.6
9 infective dermatitis associated with htlv-1 10.6
10 adult t-cell leukemia 10.5
11 multiple sclerosis 10.4
12 lymphoma 10.4
13 myopathy 10.4
14 peripheral nervous system disease 10.4
15 neuropathy 10.4
16 neurogenic bladder 10.3
17 myelitis 10.3
18 amyotrophic lateral sclerosis 1 10.2
19 hashimoto thyroiditis 10.2
20 osteoporosis 10.2
21 pseudopseudohypoparathyroidism 10.2
22 meningoencephalitis 10.2
23 strongyloidiasis 10.2
24 lateral sclerosis 10.2
25 thyroiditis 10.2
26 extrinsic allergic alveolitis 10.2
27 pain - chronic 10.2
28 spasticity 10.2
29 chromoblastomycosis 10.0 CXCR3 HLA-A
30 cryoglobulinemia 10.0 CXCR3 IFNL3
31 caplan's syndrome 10.0 FOXP3 HLA-A
32 stevens-johnson syndrome/toxic epidermal necrolysis 9.9 CXCR3 HLA-A
33 thymic dysplasia 9.9 FOXP3 HLA-A
34 lichen disease 9.9 CXCR3 FOXP3
35 autoimmune disease of central nervous system 9.9 CXCR3 FOXP3
36 alk-negative anaplastic large cell lymphoma 9.8 CD274 CXCR3
37 anal canal adenocarcinoma 9.8 CD274 FOXP3
38 vulvar melanoma 9.8 CD274 FOXP3
39 diabetes mellitus, insulin-dependent 9.7 FOXP3 HLA-A
40 malaria 9.5 CXCR3 FOXP3 HLA-A
41 clear cell renal cell carcinoma 9.5 CD274 CXCR3
42 systemic lupus erythematosus 9.3 CD274 CXCR3 FOXP3

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Symptoms & Phenotypes for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
2
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
3
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
4
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
5 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Early Phase 1
6 Immunosuppressive Agents Phase 2, Phase 3
7 Immunologic Factors Phase 2, Phase 3
8 Cyclosporins Phase 2, Phase 3
9 Antifungal Agents Phase 2, Phase 3
10 Dermatologic Agents Phase 2, Phase 3
11 Antirheumatic Agents Phase 2, Phase 3
12 Calcineurin Inhibitors Phase 2, Phase 3
13 Protective Agents Phase 3
14 Phosphodiesterase Inhibitors Phase 3
15 Radiation-Protective Agents Phase 3
16 Platelet Aggregation Inhibitors Phase 3
17 Free Radical Scavengers Phase 3
18 Antioxidants Phase 3
19 Vasodilator Agents Phase 3
20 Antiviral Agents Phase 2, Phase 3,Early Phase 1
21 Antimetabolites Phase 2, Phase 3
22 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
23 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
24 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
25 Reverse Transcriptase Inhibitors Phase 2, Phase 3
26
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
27
Infliximab Approved Phase 2 170277-31-3
28 Adjuvants, Immunologic Phase 2
29 Interferon-beta Phase 2
30 interferons Phase 2
31 Gastrointestinal Agents Phase 2
32 Antibodies Phase 1
33 Immunoglobulins Phase 1
34 Antibodies, Monoclonal Phase 1
35
Valproic Acid Approved, Investigational Not Applicable 99-66-1 3121
36 Integrase Inhibitors Early Phase 1
37 HIV Integrase Inhibitors Early Phase 1
38 Raltegravir Potassium Early Phase 1
39 Tranquilizing Agents Not Applicable
40 Anticonvulsants Not Applicable
41 GABA Agents Not Applicable
42 Antimanic Agents Not Applicable
43 Central Nervous System Depressants Not Applicable
44 Psychotropic Drugs Not Applicable
45 Neurotransmitter Agents Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
2 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
3 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
4 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
5 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
6 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
7 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
8 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
9 Raltegravir for HAM/TSP Completed NCT01867320 Early Phase 1 Raltegravir
10 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
11 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Completed NCT01651819 Not Applicable
12 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
13 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
14 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Not Applicable Valproic Acid

Search NIH Clinical Center for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

42
T Cells, Brain, Spinal Cord, Prostate, B Cells, Thymus, Nk Cells

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Articles related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

(show top 50) (show all 97)
# Title Authors Year
1
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
2
Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010). ( 29554087 )
2018
3
Early Juvenile HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): Study of 25 Patients. ( 29912303 )
2018
4
Proposal of Classification Criteria for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Disease Activity. ( 30090093 )
2018
5
Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 30341468 )
2018
6
Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil. ( 30466392 )
2018
7
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
8
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
9
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
10
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
11
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
12
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
13
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
14
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-I^, and TNF-I+ in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
15
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
16
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
17
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
18
Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
19
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
20
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2015
21
Common I^-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
22
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
23
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8(+) T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
24
HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 27188208 )
2015
25
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
26
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015
27
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
28
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
29
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
30
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. ( 25229227 )
2014
31
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24802839 )
2014
32
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
33
IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers. ( 25233462 )
2014
34
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25227931 )
2014
35
Genes Related to Antiviral Activity, Cell Migration, and Lysis Are Differentially Expressed in CD4(+) T Cells in Human T Cell Leukemia Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Patients. ( 24041428 )
2013
36
Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease. ( 23924924 )
2013
37
Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 23022356 )
2013
38
Neuroimmunological aspects of human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis. ( 23943469 )
2013
39
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. ( 23932323 )
2013
40
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. ( 23278610 )
2013
41
Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran. ( 23568138 )
2013
42
CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24130912 )
2013
43
Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression. ( 23756056 )
2013
44
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 23651542 )
2013
45
Contribution of Galvanic Vestibular Stimulation for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 24285967 )
2013
46
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. ( 22170554 )
2012
47
Immunopathogenesis of human T-cell leukemia virus type-1-associated myelopathy/tropical spastic paraparesis: recent perspectives. ( 23198155 )
2012
48
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 22720101 )
2012
49
Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients. ( 22990976 )
2012
50
Short communication an interferon-I^ ELISPOT assay with two cytotoxic T cell epitopes derived from HTLV-1 tax region 161-233 discriminates HTLV-1-associated myelopathy/tropical spastic paraparesis patients from asymptomatic HTLV-1 carriers in a Peruvian population. ( 21453202 )
2011

Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Expression for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Pathways related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 CD274 HLA-A

GO Terms for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Cellular components related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome membrane GO:0031901 9.16 CD274 HLA-A
2 cell surface GO:0009986 9.13 CD274 CXCR3 HLA-A
3 recycling endosome membrane GO:0055038 8.62 CD274 HLA-A

Biological processes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.5 CD274 CXCR3 HLA-A
2 negative regulation of T cell proliferation GO:0042130 9.26 CD274 FOXP3
3 negative regulation of interferon-gamma production GO:0032689 9.16 CD274 FOXP3
4 negative regulation of interleukin-10 production GO:0032693 8.96 CD274 FOXP3
5 negative regulation of activated T cell proliferation GO:0046007 8.62 CD274 FOXP3

Sources for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

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45 MeSH
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