MCID: HTL001
MIFTS: 35

Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards integrated aliases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

Name: Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis 54
Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/tropical Spastic Paraparesis 54
Tropical Spastic Paraparesis 74
Ham/tsp 54

Classifications:



External Ids:

UMLS 74 C0030481

Summaries for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

NIH Rare Diseases : 54 HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the nervous system that affects less than 2% of people with HTLV-1 infection. Signs and symptoms vary but may include slowly progressive weakness and spasticity of one or both legs, exaggerated reflexes, muscle contractions in the ankle, and lower back pain. Other features may include urinary incontinence and minor sensory changes, especially burning or prickling sensations and loss of vibration sense. The reason some people with HTLV-1 infection develop HAM/TSTP is not well understood. Treatment generally aims to control the specific symptoms, as there is no standard treatment available.Interferon alpha may be beneficial over short periods, and some aspects of the disease may be improved with interferon beta. Other medications may include immune globulin, oral corticosteroids, and muscle relaxers such as baclofen or tizanidine.

MalaCards based summary : Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis, also known as human t-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis, is related to tropical spastic paraparesis and hashimoto thyroiditis. An important gene associated with Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis is IFNL3 (Interferon Lambda 3), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and IL12-mediated signaling events. The drugs Miconazole and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and thyroid.

Related Diseases for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 67, show less)
# Related Disease Score Top Affiliating Genes
1 tropical spastic paraparesis 32.8 CXCR3 IFNG IFNL3
2 hashimoto thyroiditis 30.1 CXCR3 IFNG
3 myelopathy, htlv-1-associated 12.1
4 human t-cell leukemia virus type 1 12.0
5 retrovirus-associated myelopathy 11.7
6 spastic paraparesis 11.1
7 leukemia 10.6
8 t-cell leukemia 10.6
9 dermatitis 10.6
10 infective dermatitis associated with htlv-1 10.6
11 adult t-cell leukemia 10.5
12 neurogenic bladder 10.3
13 myelitis 10.3
14 multiple sclerosis 10.3
15 muscle disorders 10.3
16 lymphoma 10.3
17 myopathy 10.3
18 peripheral nervous system disease 10.3
19 neuropathy 10.3
20 amyotrophic lateral sclerosis 1 10.2
21 osteoporosis 10.2
22 pseudopseudohypoparathyroidism 10.2
23 meningoencephalitis 10.2
24 strongyloidiasis 10.2
25 lateral sclerosis 10.2
26 thyroiditis 10.2
27 extrinsic allergic alveolitis 10.2
28 pain - chronic 10.2
29 spasticity 10.2
30 cryoglobulinemia 10.1 CXCR3 IFNL3
31 chromoblastomycosis 10.1 CXCR3 HLA-A
32 idiopathic bronchiectasis 10.0 HLA-A IFNG
33 histoplasmosis 10.0 HLA-A IFNG
34 intermediate uveitis 10.0 CXCR3 IFNG
35 uveitis 10.0 CXCR3 IFNG
36 orofacial granulomatosis 10.0 CXCR3 IFNG
37 cytomegalovirus retinitis 10.0 HLA-A IFNG
38 nonspecific interstitial pneumonia 10.0 CXCR3 IFNG
39 lichen disease 10.0 CXCR3 IFNG
40 erythema multiforme 10.0 CXCR3 IFNG
41 hematopoietic stem cell transplantation 10.0 HLA-A IFNG
42 proliferative glomerulonephritis 10.0 CXCR3 IFNG
43 spondyloarthropathy 10.0 HLA-A IFNG
44 herpes zoster 10.0 HLA-A IFNG
45 bronchiolitis obliterans 10.0 CXCR3 IFNG
46 secondary progressive multiple sclerosis 10.0 CXCR3 IFNG
47 dengue hemorrhagic fever 10.0 HLA-A IFNG
48 pulmonary sarcoidosis 10.0 CXCR3 IFNG
49 autoimmune disease of central nervous system 10.0 CXCR3 IFNG
50 allergic contact dermatitis 10.0 CXCR3 IFNG
51 contact dermatitis 10.0 CXCR3 IFNG
52 lymphadenitis 10.0 CXCR3 IFNG
53 graft-versus-host disease 10.0 HLA-A IFNG
54 lichen planus 9.9 CXCR3 IFNG
55 sarcoidosis 1 9.9 CXCR3 IFNG
56 alk-negative anaplastic large cell lymphoma 9.9 CD274 CXCR3
57 mycobacterium tuberculosis 1 9.9 CXCR3 IFNG
58 nervous system disease 9.9 CXCR3 IFNG
59 central nervous system disease 9.9 CXCR3 IFNG
60 behcet syndrome 9.8 HLA-A IFNG
61 respiratory system disease 9.7 CD274 IFNG
62 stevens-johnson syndrome/toxic epidermal necrolysis 9.7 CXCR3 HLA-A IFNG
63 diabetes mellitus, insulin-dependent 9.7 HLA-A IFNG
64 malaria 9.6 CXCR3 HLA-A IFNG
65 human immunodeficiency virus type 1 9.5 CD274 HLA-A IFNG
66 clear cell renal cell carcinoma 9.5 CD274 CXCR3
67 systemic lupus erythematosus 9.4 CD274 CXCR3 IFNG

Graphical network of the top 20 diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:



Diseases related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Symptoms & Phenotypes for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs & Therapeutics for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Drugs for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 45, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
2
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
3
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
4
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
5 Dermatologic Agents Phase 2, Phase 3
6 Cyclosporins Phase 2, Phase 3
7 Antifungal Agents Phase 2, Phase 3
8 Immunologic Factors Phase 2, Phase 3
9 Calcineurin Inhibitors Phase 2, Phase 3
10 Immunosuppressive Agents Phase 2, Phase 3
11 Antirheumatic Agents Phase 2, Phase 3
12 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Early Phase 1
13 Protective Agents Phase 3
14 Radiation-Protective Agents Phase 3
15 Free Radical Scavengers Phase 3
16 Antioxidants Phase 3
17 Vasodilator Agents Phase 3
18 Platelet Aggregation Inhibitors Phase 3
19 Phosphodiesterase Inhibitors Phase 3
20 Antiviral Agents Phase 2, Phase 3,Early Phase 1
21 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
22 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
23 Reverse Transcriptase Inhibitors Phase 2, Phase 3
24 Antimetabolites Phase 2, Phase 3
25 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
26
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
27
Infliximab Approved Phase 2 170277-31-3
28 Adjuvants, Immunologic Phase 2
29 interferons Phase 2
30 Interferon-beta Phase 2
31 Gastrointestinal Agents Phase 2
32 Antibodies, Monoclonal Phase 1
33 Immunoglobulins Phase 1
34 Antibodies Phase 1
35
Valproic Acid Approved, Investigational Not Applicable 99-66-1 3121
36 Integrase Inhibitors Early Phase 1
37 Raltegravir Potassium Early Phase 1
38 HIV Integrase Inhibitors Early Phase 1
39 Central Nervous System Depressants Not Applicable
40 Neurotransmitter Agents Not Applicable
41 Tranquilizing Agents Not Applicable
42 Psychotropic Drugs Not Applicable
43 Antimanic Agents Not Applicable
44 GABA Agents Not Applicable
45 Anticonvulsants Not Applicable

Interventional clinical trials:

(showing 14, show less)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
2 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
3 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
4 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
5 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
6 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
7 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
8 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
9 Raltegravir for HAM/TSP Completed NCT01867320 Early Phase 1 Raltegravir
10 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
11 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Completed NCT01651819 Not Applicable
12 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
13 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
14 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Not Applicable Valproic Acid

Search NIH Clinical Center for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Genetic Tests for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Anatomical Context for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

MalaCards organs/tissues related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

42
T Cells, Brain, Thyroid, Spinal Cord, Prostate, Thymus, Nk Cells

Publications for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Articles related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis:

(showing 99, show less)
# Title Authors Year
1
Curcumin increased the expression of c-FLIP in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 31074052 )
2019
2
Functional capacity of natural killer cells in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 31101076 )
2019
3
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2018
4
Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 30341468 )
2018
5
Role of Integrin Signaling Activation on the Development of Human T Cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-Infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
6
Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010). ( 29554087 )
2018
7
Proposal of Classification Criteria for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Disease Activity. ( 30090093 )
2018
8
Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil. ( 30466392 )
2018
9
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
10
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
11
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
12
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
13
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
14
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-γ, and TNF-α in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
15
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
16
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
17
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2016
18
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
19
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
20
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8+ T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
21
HTLV-1-associated myelopathy/tropical spastic paraparesis and peripheral neuropathy following live-donor renal transplantation. ( 25196582 )
2015
22
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
23
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
24
Editorial Commentary: Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
25
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
26
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
27
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
28
Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
29
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
30
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015
31
HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 27188208 )
2015
32
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
33
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24802839 )
2014
34
Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25227931 )
2014
35
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. ( 25229227 )
2014
36
IL28B gene polymorphism SNP rs8099917 genotype GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers. ( 25233462 )
2014
37
Neuroimmunological aspects of human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis. ( 23943469 )
2014
38
Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4(+) T cells in human t cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. ( 24041428 )
2014
39
Invasion of histiocytic sarcoma into the spinal cord of HTLV-1 tax transgenic mice with HTLV-1-associated myelopathy/tropical spastic paraparesis-like disease. ( 23924924 )
2013
40
Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 23022356 )
2013
41
Co-presentation of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis and adult-onset infective dermatitis associated with HTLV-1 infection. ( 23278610 )
2013
42
Clinical features of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in northeast Iran. ( 23568138 )
2013
43
Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 23651542 )
2013
44
Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression. ( 23756056 )
2013
45
Clustering of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH) in Salvador, Bahia, Brazil. ( 23932323 )
2013
46
CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24130912 )
2013
47
Contribution of Galvanic Vestibular Stimulation for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 24285967 )
2013
48
Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. ( 22170554 )
2012
49
Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 22720101 )
2012
50
Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients. ( 22990976 )
2012
51
Immunopathogenesis of human T-cell leukemia virus type-1-associated myelopathy/tropical spastic paraparesis: recent perspectives. ( 23198155 )
2012
52
Characteristics of Chronic Pain and Its Impact on Quality of Life of Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 20842011 )
2011
53
Short communication an interferon-γ ELISPOT assay with two cytotoxic T cell epitopes derived from HTLV-1 tax region 161-233 discriminates HTLV-1-associated myelopathy/tropical spastic paraparesis patients from asymptomatic HTLV-1 carriers in a Peruvian population. ( 21453202 )
2011
54
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 21510232 )
2011
55
Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders. ( 21851845 )
2011
56
Plasma proteome analysis in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 21992623 )
2011
57
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP): still an obscure disease. ( 22300227 )
2011
58
HTLV-1 associated myelopathy/tropical spastic paraparesis: how far have we come? ( 22519224 )
2011
59
Evaluation of host genetic and viral factors as surrogate markers for HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian HTLV-1-infected patients. ( 20087941 )
2010
60
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 20169122 )
2010
61
Correlation of HTLV-1 Tax genetic diversity with HTLV-1 associated myelopathy/tropical spastic paraparesis progression and HTLV-1a genotypes in an HTLV-1 endemic region in Argentina. ( 20572090 )
2010
62
Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. ( 20851016 )
2010
63
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 19228429 )
2009
64
High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1. ( 19578703 )
2009
65
Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders. ( 19678766 )
2009
66
Is human T cell lymphotropic type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) syndrome a neglected disease? ( 19936247 )
2009
67
Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. ( 17884099 )
2008
68
The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 18664281 )
2008
69
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) inflammatory network. ( 18691139 )
2008
70
Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection. ( 17278060 )
2007
71
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. ( 17717136 )
2007
72
Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis. ( 18078583 )
2007
73
Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 16503269 )
2006
74
Flow cytometry evaluation of the T-cell receptor Vbeta repertoire among human T-cell lymphotropic virus type-1 (HTLV-1) infected individuals: effect of interferon alpha therapy in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 16545396 )
2006
75
Proviral load and immune markers associated with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Peru. ( 17034574 )
2006
76
Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 15655786 )
2005
77
Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. ( 15722539 )
2005
78
ApaI polymorphism of vitamin D receptor gene is associated with susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in HTLV-1 infected individuals. ( 15850579 )
2005
79
A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 15961107 )
2005
80
HTLV-1-associated myelopathy/tropical spastic paraparesis accompanied with psoriasis. ( 15178221 )
2004
81
Low frequency of CD94/NKG2A+ T lymphocytes in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis, but not in asymptomatic carriers. ( 12560226 )
2003
82
High frequencies of Th1-type CD4(+) T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 11964301 )
2002
83
Detection of myelin basic protein in cerebrospinal fluid and serum from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 12564844 )
2002
84
HTLV-1-associated myelopathy/tropical spastic paraparesis with pseudohypoparathyroidism. ( 11148245 )
2001
85
Flow cytometric differentiation of Asian and Western types of multiple sclerosis, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and hyperIgEaemic myelitis by analyses of memory CD4 positive T cell subsets and NK cell subsets. ( 10967179 )
2000
86
Common human T cell leukemia virus type 1 (HTLV-1) integration sites in cerebrospinal fluid and blood lymphocytes of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis indicate that HTLV-1 crosses the blood-brain barrier via clonal HTLV-1-infected cells. ( 10979898 )
2000
87
The role of human T-lymphotropic virus type 1 (HTLV-1)-infected dendritic cells in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 10233916 )
1999
88
Antibodies to cardiolipin and beta2-glycoprotein-1 in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 10342713 )
1999
89
Increased levels of soluble Fas ligand in CSF of rapidly progressive HTLV-1-associated myelopathy/tropical spastic paraparesis patients. ( 10430056 )
1999
90
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis hypothesis. A shift of homologous peptides pairs, central nervous system (CNS)/HTLF-1, HTLV-1/thymus, thymus/CNS, in a thymus-like CNS environment, underlies the pathogenesis of HAM/TSP. ( 10459844 )
1999
91
Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. ( 9491917 )
1998
92
HTLV-1 associated myelopathy/tropical spastic paraparesis in Egypt. ( 8912212 )
1996
93
Clinical neurophysiological comparative study on HTLV-1 associated myelopathy/tropical spastic paraparesis. ( 8555734 )
1995
94
FK506 and cyclosporin a regulate proliferation and proto-oncogene expression in HTLV-1-associated myelopathy/tropical-spastic-paraparesis-derived T cells. ( 7683633 )
1993
95
Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations. ( 8213080 )
1993
96
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. ( 8372632 )
1993
97
HTLV-1-associated myelopathy/tropical spastic paraparesis-like rats by intravenous injection of HTLV-1-producing rabbit or human T-cell line into adult WKA rats. ( 8407544 )
1993
98
HTLV-1 associated myelopathy/tropical spastic paraparesis with adult T-cell leukemia. ( 1736016 )
1992
99
Novel complications with HTLV-1-associated myelopathy/tropical spastic paraparesis: interstitial cystitis and persistent prostatitis. ( 1353753 )
1992

Variations for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Expression for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Search GEO for disease gene expression data for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis.

Pathways for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Pathways related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(showing 4, show less)
# Super pathways Score Top Affiliating Genes
1 11.42 CD274 HLA-A
2
Show member pathways
11.21 HLA-A IFNG
3 10.86 CXCR3 IFNG
4
Show member pathways
10.41 HLA-A IFNG

GO Terms for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

Cellular components related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 early endosome membrane GO:0031901 9.16 CD274 HLA-A
2 cell surface GO:0009986 9.13 CD274 CXCR3 HLA-A
3 recycling endosome membrane GO:0055038 8.62 CD274 HLA-A

Biological processes related to Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.16 HLA-A IFNG
2 cell surface receptor signaling pathway GO:0007166 9.13 CD274 CXCR3 IFNG
3 immune response GO:0006955 8.92 CD274 CXCR3 HLA-A IFNG

Sources for Htlv-1 Associated Myelopathy/tropical Spastic Paraparesis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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45 MeSH
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47 MGI
50 NCI
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55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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