HGE
MCID: HMN002
MIFTS: 31

Human Granulocytic Anaplasmosis (HGE)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Human Granulocytic Anaplasmosis

MalaCards integrated aliases for Human Granulocytic Anaplasmosis:

Name: Human Granulocytic Anaplasmosis 12 15 17
Human Granulocytic Ehrlichiosis 12 74 20 54
Hge 12 20
Human Ehrlichial Infection, Human Granulocytic Type 20
Human Anaplasmosis Due to Anaplasma Phagocytophilum 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050025
UMLS 71 C0483368

Summaries for Human Granulocytic Anaplasmosis

Disease Ontology : 12 An ehrlichiosis that results in infection located in granular leukocyte, has material basis in Anaplasma phagocytophilum, which is transmitted by lone start tick (Amblyomma americanum ). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash.

MalaCards based summary : Human Granulocytic Anaplasmosis, also known as human granulocytic ehrlichiosis, is related to inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 and human monocytic ehrlichiosis. An important gene associated with Human Granulocytic Anaplasmosis is SELPLG (Selectin P Ligand), and among its related pathways/superpathways is Phagosome. Affiliated tissues include neutrophil, myeloid and kidney, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Human granulocytic anaplasmosis (HGA) is a tick-borne, infectious disease caused by Anaplasma... more...

Related Diseases for Human Granulocytic Anaplasmosis

Diseases related to Human Granulocytic Anaplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 30.5 HSPD1 EDC4
2 human monocytic ehrlichiosis 30.1 RAB5A KRTAP26-1 HSPD1 DNASE1L1
3 ehrlichiosis 29.7 TFRC SELPLG HSPD1 HGD FUT7 EDC4
4 lyme disease 10.7
5 neutropenia 10.7
6 thrombocytopenia 10.6
7 disease by infectious agent 10.4
8 retinitis pigmentosa 44 10.4
9 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 10.4
10 epidemic typhus 10.4
11 babesiosis 10.4
12 pancytopenia 10.4
13 47,xyy 10.4
14 scrub typhus 10.3
15 lymphopenia 10.3
16 cytokine deficiency 10.3
17 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
18 hemophagocytic lymphohistiocytosis 10.2
19 tick-borne encephalitis 10.2
20 severe combined immunodeficiency 10.2
21 encephalitis 10.2
22 adult respiratory distress syndrome 10.2
23 endocervicitis 10.1 SELPLG HSPD1
24 pelger-huet anomaly 10.1
25 leukemia, acute myeloid 10.1
26 neutrophilic dermatosis, acute febrile 10.1
27 myelodysplastic syndrome 10.1
28 thrombocytopenia 5 10.1
29 korean hemorrhagic fever 10.1
30 exanthem 10.1
31 bacterial infectious disease 10.1
32 meningoencephalitis 10.1
33 siberian tick typhus 10.1
34 spotted fever 10.1
35 hantavirus hemorrhagic fever with renal syndrome 10.1
36 leukemia 10.1
37 membranoproliferative glomerulonephritis 10.1
38 glomerulonephritis 10.1
39 acute kidney failure 10.1
40 purpura 10.1
41 secondary syphilis 10.1
42 syphilis 10.1
43 kidney disease 10.1
44 myocarditis 10.1
45 etv6 thrombocytopenia and predisposition to leukemia 10.1
46 chromosomal triplication 10.1
47 macrophage activation syndrome 10.1
48 neisseria meningitidis infection 10.1
49 syncope 10.1
50 posttransplant acute limbic encephalitis 10.1

Graphical network of the top 20 diseases related to Human Granulocytic Anaplasmosis:



Diseases related to Human Granulocytic Anaplasmosis

Symptoms & Phenotypes for Human Granulocytic Anaplasmosis

MGI Mouse Phenotypes related to Human Granulocytic Anaplasmosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.83 ABI1 ANK1 CXCR2 CYBB EDC4 EPS8L3
2 immune system MP:0005387 9.36 ABI1 ANK1 CXCR2 CYBB FUT7 HGD

Drugs & Therapeutics for Human Granulocytic Anaplasmosis

Search Clinical Trials , NIH Clinical Center for Human Granulocytic Anaplasmosis

Genetic Tests for Human Granulocytic Anaplasmosis

Anatomical Context for Human Granulocytic Anaplasmosis

MalaCards organs/tissues related to Human Granulocytic Anaplasmosis:

40
Neutrophil, Myeloid, Kidney, Endothelial, Bone Marrow, Bone, Whole Blood

Publications for Human Granulocytic Anaplasmosis

Articles related to Human Granulocytic Anaplasmosis:

(show top 50) (show all 783)
# Title Authors PMID Year
1
Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein. 61 54
15618156 2005
2
Sequence analysis of the ank gene of granulocytic ehrlichiae. 54 61
10921951 2000
3
Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1. 61 54
10834846 2000
4
Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. 54 61
10754283 2000
5
Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. 54 61
10225882 1999
6
Acute brachial plexitis caused by human granulocytic anaplasmosis. 61
33582895 2021
7
Incompetence of the Asian Longhorned Tick (Acari: Ixodidae) in Transmitting the Agent of Human Granulocytic Anaplasmosis in the United States. 61
33590859 2021
8
The Role of Peridomestic Animals in the Eco-Epidemiology of Anaplasma phagocytophilum. 61
33547531 2021
9
Pathogen Coinfections Harbored by Adult Ixodes scapularis from White-Tailed Deer Compared with Questing Adults Across Sites in Maryland, USA. 61
33316206 2021
10
Ecotyping of Anaplasma phagocytophilum from Wild Ungulates and Ticks Shows Circulation of Zoonotic Strains in Northeastern Italy. 61
33530571 2021
11
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. 61
33501959 2021
12
Recurrent Fevers in a Triathlete. 61
33575137 2021
13
Prevalence of Borrelia burgdorferi and Anaplasma phagocytophilum in Ixodid Ticks from Southeastern Ukraine. 61
33475465 2021
14
Case Report: Anaplasmosis in Canada: Locally Acquired Anaplasma phagocytophilum Infection in Alberta. 61
32959772 2020
15
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. 61
33252652 2020
16
First identification of Anaplasma phagocytophilum in both a biting tick Ixodes nipponensis and a patient in Korea: a case report. 61
33176719 2020
17
Human Granulocytic Anaplasmosis Diagnosed Based on a Peripheral Blood Smear Test in South Korea: a Case Report. 61
32475869 2020
18
Identification and characterization of an actin filament-associated Anaplasma phagocytophilum protein. 61
32768516 2020
19
Identification of Zoonotic Tick-Borne Pathogens from Korean Water Deer (Hydropotes inermis argyropus). 61
32598238 2020
20
Verification of mono- and mixed contaminations transmitting agents tick-borne infections. 61
33245658 2020
21
Prevalence and Coinfection of Three Tick-Borne Pathogens in Questing Adult Blacklegged Ticks Ixodes scapularis (Vilas County, Wisconsin). 61
32283047 2020
22
Rare case of severe rhabdomyolysis secondary to human granulocytic anaplasmosis. 61
32305154 2020
23
Spatio-Temporal Dynamics of Tick-Borne Diseases in North-Central Wisconsin from 2000-2016. 61
32679849 2020
24
The absence of the drhm gene is not a marker for human-pathogenicity in European Anaplasma phagocytophilum strains. 61
32381072 2020
25
Development of a Sensitive and Rapid Recombinase Polymerase Amplification Assay for Detection of Anaplasma phagocytophilum. 61
32132189 2020
26
Assessment of Borrelia miyamotoi in febrile patients and ticks in Alsace, an endemic area for Lyme borreliosis in France. 61
32303256 2020
27
Rapid and Highly Sensitive DNA Flow Technology Platform to Detect Tick-Borne Bacterial Pathogens in Clinical Samples. 61
31638480 2020
28
Surge in Anaplasmosis Cases in Maine, USA, 2013-2017. 61
31961312 2020
29
Experimental Ixodes ricinus-Sheep Cycle of Anaplasma phagocytophilum NV2Os Propagated in Tick Cell Cultures. 61
32118063 2020
30
Analysis of CCL-4, CCL-17, CCL-20 and IL-8 concentrations in the serum of patients with tick-borne encephalitis and anaplasmosis. 61
31561102 2020
31
Genetic diversity of Anaplasma and Ehrlichia bacteria found in Dermacentor and Ixodes ticks in Mongolia. 61
31677968 2020
32
Occurrence of <i>Borrelia burgdorferi</i> sensu lato, <i>Anaplasma phagocytophilum</i> and <i>Babesia microti</i> in <i>Ixodes ricinus</i> ticks collected from selected areas of Opolskie Province in south-west Poland. 61
31885226 2019
33
A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe. 61
31864403 2019
34
Cross-kingdom analysis of nymphal-stage Ixodes scapularis microbial communities in relation to Borrelia burgdorferi infection and load. 61
31722384 2019
35
Recent Emergence of Anaplasma phagocytophilum in Ontario, Canada: Early Serological and Entomological Indicators. 61
31628739 2019
36
Acute Kidney Injury Associated With Human Granulocytic Anaplasmosis: A Case Report. 61
31200977 2019
37
Prevalence of Anaplasma phagocytophilum in Ixodes ricinus and Dermacentor reticulatus and Coinfection with Borrelia burgdorferi and Tick-Borne Encephalitis Virus in Western Ukraine. 61
31211655 2019
38
Co-Infection of Scrub Typhus and Human Granulocytic Anaplasmosis in Korea, 2006. 61
31602827 2019
39
Fulminant Human Granulocytic Anaplasmosis after CABG: An Unusual Occurrence. 61
31132329 2019
40
Insight of diagnostic performance using B-cell epitope antigens derived from triple P44-related proteins of Anaplasma phagocytophilum. 61
31182246 2019
41
Human granulocytic anaplasmosis in Kinmen, an offshore island of Taiwan. 61
31539395 2019
42
The redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells. 61
31520000 2019
43
Prevalence of Anaplasma phagocytophilum in humans in Belgium for the period 2013-2016. 61
30029581 2019
44
Seroprevalence of Tick-Borne Anaplasma phagocytophilum Infection in Healthy Adult Population and Patients with Acute Undifferentiated Fever from the Yunnan Province of China. 61
30615589 2019
45
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
46
Anaplasma phagocytophilum presenting with orchitis in a renal transplant recipient. 61
31215144 2019
47
Rapid and sensitive detection of Anaplasma phagocytophilum using a newly developed recombinase polymerase amplification assay. 61
31029698 2019
48
Value of PCR, Serology, and Blood Smears for Human Granulocytic Anaplasmosis Diagnosis, France. 61
31002073 2019
49
Molecular Detection and Characterization of p44/msp2 Multigene Family of Anaplasma phagocytophilum from Haemaphysalis longicornis in Mie Prefecture, Japan. 61
30700658 2019
50
[Cytogenetic, kariopathological and morphological abnormalities of spermatozoa and urothelial cells in human granulocytic anaplasmosis depending on polymorphism of the gene of DNA ligase IV]. 61
31184023 2019

Variations for Human Granulocytic Anaplasmosis

Expression for Human Granulocytic Anaplasmosis

Search GEO for disease gene expression data for Human Granulocytic Anaplasmosis.

Pathways for Human Granulocytic Anaplasmosis

Pathways related to Human Granulocytic Anaplasmosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.98 TFRC RAB5A CYBB

GO Terms for Human Granulocytic Anaplasmosis

Biological processes related to Human Granulocytic Anaplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.26 RIPK2 FUT7 CYBB CXCR2
2 positive regulation of interferon-alpha production GO:0032727 8.62 RIPK2 HSPD1

Sources for Human Granulocytic Anaplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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