HGE
MCID: HMN002
MIFTS: 32

Human Granulocytic Anaplasmosis (HGE)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Human Granulocytic Anaplasmosis

MalaCards integrated aliases for Human Granulocytic Anaplasmosis:

Name: Human Granulocytic Anaplasmosis 12 15 17
Human Granulocytic Ehrlichiosis 12 74 52 54
Hge 12 52
Human Ehrlichial Infection, Human Granulocytic Type 52
Human Anaplasmosis Due to Anaplasma Phagocytophilum 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050025
UMLS 71 C0483368

Summaries for Human Granulocytic Anaplasmosis

Disease Ontology : 12 An ehrlichiosis that results in infection located in granular leukocyte, has material basis in Anaplasma phagocytophilum, which is transmitted by lone start tick (Amblyomma americanum ). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash.

MalaCards based summary : Human Granulocytic Anaplasmosis, also known as human granulocytic ehrlichiosis, is related to human monocytic ehrlichiosis and pancytopenia. An important gene associated with Human Granulocytic Anaplasmosis is SELPLG (Selectin P Ligand). Affiliated tissues include neutrophil, monocytes and testes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 74 Human granulocytic anaplasmosis (HGA) is a tick-borne, infectious disease caused by Anaplasma... more...

Related Diseases for Human Granulocytic Anaplasmosis

Diseases related to Human Granulocytic Anaplasmosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 human monocytic ehrlichiosis 30.7 MMP12 KRTAP26-1 HSPD1
2 pancytopenia 29.7 LIG4 CYGB CD40LG
3 ehrlichiosis 28.9 TFRC SELPLG MMP12 HSPD1 HGS HGD
4 lyme disease 10.6
5 neutropenia 10.6
6 thrombocytopenia 10.6
7 immunodeficiency with hyper-igm, type 4 10.4 LIG4 CD40LG
8 inclusion conjunctivitis 10.3 HSPD1 CD40LG
9 bacillary angiomatosis 10.3 HSPD1 CD40LG
10 opportunistic bacterial infectious disease 10.3 HSPD1 CD40LG
11 retinitis pigmentosa 44 10.3
12 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 10.3
13 epidemic typhus 10.3
14 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 10.3
15 babesiosis 10.3
16 immunodeficiency with hyper-igm, type 5 10.3 LIG4 CD40LG
17 chancroid 10.3 HSPD1 CD40LG
18 cat-scratch disease 10.3 HSPD1 CD40LG
19 scrub typhus 10.3
20 lymphopenia 10.3
21 bartonellosis 10.3 HSPD1 CD40LG
22 pustulosis palmaris et plantaris 10.2 SELPLG CD40LG
23 cervical adenitis 10.2 HSPD1 CD40LG
24 47,xyy 10.2
25 rocky mountain spotted fever 10.2 HSPD1 CD40LG
26 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
27 hemophagocytic lymphohistiocytosis 10.2
28 tick-borne encephalitis 10.2
29 severe combined immunodeficiency 10.2
30 encephalitis 10.2
31 folic acid deficiency anemia 10.2 TFRC CYGB
32 chlamydia pneumonia 10.2 HSPD1 CD40LG
33 cytokine deficiency 10.1
34 salpingitis 10.1 HSPD1 CD40LG
35 splenic sequestration 10.0 CYGB CD40LG
36 urethritis 10.0 HSPD1 CD40LG
37 pelger-huet anomaly 10.0
38 leukemia, acute myeloid 10.0
39 neutrophilic dermatosis, acute febrile 10.0
40 myelodysplastic syndrome 10.0
41 thrombocytopenia 5 10.0
42 korean hemorrhagic fever 10.0
43 exanthem 10.0
44 bacterial infectious disease 10.0
45 meningoencephalitis 10.0
46 siberian tick typhus 10.0
47 spotted fever 10.0
48 hantavirus hemorrhagic fever with renal syndrome 10.0
49 leukemia 10.0
50 membranoproliferative glomerulonephritis 10.0

Graphical network of the top 20 diseases related to Human Granulocytic Anaplasmosis:



Diseases related to Human Granulocytic Anaplasmosis

Symptoms & Phenotypes for Human Granulocytic Anaplasmosis

MGI Mouse Phenotypes related to Human Granulocytic Anaplasmosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ABI1 ANK1 CD40LG CXCR2 CYBB CYGB
2 hematopoietic system MP:0005397 10.07 ABI1 AKR1B10 ANK1 CD40LG CXCR2 CYBB
3 cellular MP:0005384 10.06 ABI1 CD40LG CXCR2 CYBB CYGB FUT7
4 homeostasis/metabolism MP:0005376 9.93 ABI1 AKR1B10 ANK1 CD40LG CXCR2 CYBB
5 immune system MP:0005387 9.73 ABI1 ANK1 CD40LG CXCR2 CYBB EDC4
6 renal/urinary system MP:0005367 9.17 ANK1 CD40LG CXCR2 CYBB CYGB HGD

Drugs & Therapeutics for Human Granulocytic Anaplasmosis

Search Clinical Trials , NIH Clinical Center for Human Granulocytic Anaplasmosis

Genetic Tests for Human Granulocytic Anaplasmosis

Anatomical Context for Human Granulocytic Anaplasmosis

MalaCards organs/tissues related to Human Granulocytic Anaplasmosis:

40
Neutrophil, Monocytes, Testes, Myeloid, Colon, Kidney, Endothelial

Publications for Human Granulocytic Anaplasmosis

Articles related to Human Granulocytic Anaplasmosis:

(show top 50) (show all 782)
# Title Authors PMID Year
1
Anaplasma phagocytophilum modulates gp91phox gene expression through altered interferon regulatory factor 1 and PU.1 levels and binding of CCAAT displacement protein. 61 54
15618156 2005
2
Sequence analysis of the ank gene of granulocytic ehrlichiae. 61 54
10921951 2000
3
Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1. 54 61
10834846 2000
4
Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. 54 61
10754283 2000
5
Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. 61 54
10225882 1999
6
A case of human granulocytic anaplasmosis diagnosed by a peripheral blood smear test in South Korea. 61
32475869 2020
7
The absence of the drhm gene is not a marker for human-pathogenicity in European Anaplasma phagocytophilum strains. 61
32381072 2020
8
Assessment of Borrelia miyamotoi in febrile patients and ticks in Alsace, an endemic area for Lyme borreliosis in France. 61
32303256 2020
9
Development of a Sensitive and Rapid Recombinase Polymerase Amplification Assay for Detection of Anaplasma phagocytophilum. 61
32132189 2020
10
Rare case of severe rhabdomyolysis secondary to human granulocytic anaplasmosis. 61
32305154 2020
11
Prevalence and Coinfection of Three Tick-Borne Pathogens in Questing Adult Blacklegged Ticks Ixodes scapularis (Vilas County, Wisconsin). 61
32283047 2020
12
Rapid and Highly Sensitive DNA Flow Technology Platform to Detect Tick-Borne Bacterial Pathogens in Clinical Samples. 61
31638480 2020
13
Surge in Anaplasmosis Cases in Maine, USA, 2013-2017. 61
31961312 2020
14
Genetic diversity of Anaplasma and Ehrlichia bacteria found in Dermacentor and Ixodes ticks in Mongolia. 61
31677968 2020
15
Analysis of CCL-4, CCL-17, CCL-20 and IL-8 concentrations in the serum of patients with tick-borne encephalitis and anaplasmosis. 61
31561102 2020
16
Experimental Ixodes ricinus-Sheep Cycle of Anaplasma phagocytophilum NV2Os Propagated in Tick Cell Cultures. 61
32118063 2020
17
Occurrence of <i>Borrelia burgdorferi</i> sensu lato, <i>Anaplasma phagocytophilum</i> and <i>Babesia microti</i> in <i>Ixodes ricinus</i> ticks collected from selected areas of Opolskie Province in south-west Poland. 61
31885226 2019
18
Recent Emergence of Anaplasma phagocytophilum in Ontario, Canada: Early Serological and Entomological Indicators. 61
31628739 2019
19
Cross-kingdom analysis of nymphal-stage Ixodes scapularis microbial communities in relation to Borrelia burgdorferi infection and load. 61
31722384 2019
20
A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe. 61
31864403 2019
21
Acute Kidney Injury Associated With Human Granulocytic Anaplasmosis: A Case Report. 61
31200977 2019
22
Prevalence of Anaplasma phagocytophilum in Ixodes ricinus and Dermacentor reticulatus and Coinfection with Borrelia burgdorferi and Tick-Borne Encephalitis Virus in Western Ukraine. 61
31211655 2019
23
Co-Infection of Scrub Typhus and Human Granulocytic Anaplasmosis in Korea, 2006. 61
31602827 2019
24
Fulminant Human Granulocytic Anaplasmosis after CABG: An Unusual Occurrence. 61
31132329 2019
25
Insight of diagnostic performance using B-cell epitope antigens derived from triple P44-related proteins of Anaplasma phagocytophilum. 61
31182246 2019
26
Human granulocytic anaplasmosis in Kinmen, an offshore island of Taiwan. 61
31539395 2019
27
The redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells. 61
31520000 2019
28
Seroprevalence of Tick-Borne Anaplasma phagocytophilum Infection in Healthy Adult Population and Patients with Acute Undifferentiated Fever from the Yunnan Province of China. 61
30615589 2019
29
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
30
Prevalence of Anaplasma phagocytophilum in humans in Belgium for the period 2013-2016. 61
30029581 2019
31
Anaplasma phagocytophilum presenting with orchitis in a renal transplant recipient. 61
31215144 2019
32
Rapid and sensitive detection of Anaplasma phagocytophilum using a newly developed recombinase polymerase amplification assay. 61
31029698 2019
33
Molecular Detection and Characterization of p44/msp2 Multigene Family of Anaplasma phagocytophilum from Haemaphysalis longicornis in Mie Prefecture, Japan. 61
30700658 2019
34
Value of PCR, Serology, and Blood Smears for Human Granulocytic Anaplasmosis Diagnosis, France. 61
31002073 2019
35
[Cytogenetic, kariopathological and morphological abnormalities of spermatozoa and urothelial cells in human granulocytic anaplasmosis depending on polymorphism of the gene of DNA ligase IV]. 61
31184023 2019
36
Molecular Detection of Anaplasma phagocytophilum in Blood-Sucking Flies (Diptera: Tabanidae) in Poland. 61
30615168 2019
37
Development of TEM-1 β-lactamase based protein translocation assay for identification of Anaplasma phagocytophilum type IV secretion system effector proteins. 61
30862835 2019
38
Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea. 61
30914905 2019
39
Predominant Shift of Different P44-Expressing Anaplasma phagocytophilum in Infected HL-60, THP-1, NB4, and RF/6A Cell Lines. 61
30381676 2019
40
Infection by Anaplasma phagocytophilum Requires Recruitment of Low-Density Lipoprotein Cholesterol by Flotillins. 61
30914515 2019
41
The prevalence and clinical characteristics of tick-borne diseases at One Sentinel Hospital in Northeastern China. 61
30066666 2019
42
Repellents as a major element in the context of prevention of tick-borne diseases 61
31385684 2019
43
Inflammatory arthritis: a unique presentation of human anaplasmosis. 61
30539351 2019
44
Morulae in neutrophils: A diagnostic clue for human granulocytic anaplasmosis. 61
30847278 2019
45
Analysis of epidemiological characteristics of four natural-focal diseases in Shandong Province, China in 2009-2017: A descriptive analysis. 61
31454372 2019
46
Molecular Detection and Phylogenetic Analysis of Anaplasma phagocytophilum in Horses in Korea. 61
30630276 2018
47
VirB10 vaccination for protection against Anaplasma phagocytophilum. 61
30563470 2018
48
Identification of novel immunoreactive proteins and delineation of a specific epitope of Anaplasma phagocytophilum. 61
30217516 2018
49
Diagnosis and molecular characteristics of human infections caused by Anaplasma phagocytophilum in South Korea. 61
30353471 2018
50
Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan. 61
30419740 2018

Variations for Human Granulocytic Anaplasmosis

Expression for Human Granulocytic Anaplasmosis

Search GEO for disease gene expression data for Human Granulocytic Anaplasmosis.

Pathways for Human Granulocytic Anaplasmosis

GO Terms for Human Granulocytic Anaplasmosis

Biological processes related to Human Granulocytic Anaplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-12 production GO:0032735 9.16 HSPD1 CD40LG
2 positive regulation of interleukin-10 production GO:0032733 8.96 HSPD1 CD40LG
3 isotype switching GO:0045190 8.62 LIG4 CD40LG

Molecular functions related to Human Granulocytic Anaplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 TMEM185A TFRC STX16 SELPLG LIG4 KRTAP26-1

Sources for Human Granulocytic Anaplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....