MCID: HMN002
MIFTS: 41

Human Granulocytic Anaplasmosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Human Granulocytic Anaplasmosis

MalaCards integrated aliases for Human Granulocytic Anaplasmosis:

Name: Human Granulocytic Anaplasmosis 12 15
Human Granulocytic Ehrlichiosis 12 76 53 55
Hge 12 53
Human Ehrlichial Infection, Human Granulocytic Type 53
Human Anaplasmosis Due to Anaplasma Phagocytophilum 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050025
UMLS 73 C0483368

Summaries for Human Granulocytic Anaplasmosis

Disease Ontology : 12 An ehrlichiosis that results in infection located in granular leukocyte, has material basis in Anaplasma phagocytophilum, which is transmitted by lone start tick (Amblyomma americanum ). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash.

MalaCards based summary : Human Granulocytic Anaplasmosis, also known as human granulocytic ehrlichiosis, is related to lyme disease and ehrlichiosis, and has symptoms including headache, muscle aches and fatigue. An important gene associated with Human Granulocytic Anaplasmosis is SELPLG (Selectin P Ligand), and among its related pathways/superpathways are Insulin receptor recycling and Apoptosis-related network due to altered Notch3 in ovarian cancer. Affiliated tissues include granular leukocyte, monocytes and neutrophil, and related phenotypes are cellular and hematopoietic system

Wikipedia : 76 Human granulocytic anaplasmosis (HGA) is a tick-borne, infectious disease caused by Anaplasma... more...

Related Diseases for Human Granulocytic Anaplasmosis

Graphical network of the top 20 diseases related to Human Granulocytic Anaplasmosis:



Diseases related to Human Granulocytic Anaplasmosis

Symptoms & Phenotypes for Human Granulocytic Anaplasmosis

Symptoms:

12
  • headache
  • muscle aches
  • fatigue
  • fever
  • rash

MGI Mouse Phenotypes related to Human Granulocytic Anaplasmosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 TFRC CD40LG CXCR2 CYBB FUT7 HSPD1
2 hematopoietic system MP:0005397 9.76 ANK1 CD40LG CXCR2 CYBB FUT7 RIPK2
3 immune system MP:0005387 9.61 CD40LG CXCR2 CYBB FUT7 HGD RIPK2
4 renal/urinary system MP:0005367 9.1 ANK1 CD40LG CXCR2 CYBB HGD SELPLG

Drugs & Therapeutics for Human Granulocytic Anaplasmosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Human Anaplasmosis in Eastern France Unknown status NCT01013636

Search NIH Clinical Center for Human Granulocytic Anaplasmosis

Genetic Tests for Human Granulocytic Anaplasmosis

Anatomical Context for Human Granulocytic Anaplasmosis

The Foundational Model of Anatomy Ontology organs/tissues related to Human Granulocytic Anaplasmosis:

19
Granular Leukocyte

MalaCards organs/tissues related to Human Granulocytic Anaplasmosis:

41
Monocytes, Neutrophil, Testes, Myeloid, Pancreas, Bone, Kidney

Publications for Human Granulocytic Anaplasmosis

Articles related to Human Granulocytic Anaplasmosis:

(show top 50) (show all 277)
# Title Authors Year
1
Severe Human Granulocytic Anaplasmosis With Significantly Elevated Ferritin Levels in an Immunocompetent Host in Pennsylvania: A Case Report. ( 29468169 )
2018
2
Human granulocytic anaplasmosis acquired from a blacklegged tick in Ontario. ( 29581163 )
2018
3
Non-traumatic splenic rupture in a patient with human granulocytic anaplasmosis and focused review of the literature. ( 29500125 )
2018
4
Clinical Presentation and Outcomes of Children With Human Granulocytic Anaplasmosis. ( 28520981 )
2017
5
Case Report: Polymerase Chain Reaction Testing of Tick Bite Site Samples for the Diagnosis of Human Granulocytic Anaplasmosis. ( 28829732 )
2017
6
Human Granulocytic Anaplasmosis as a Cause of Febrile Illness in Korea Since at Least 2006. ( 28093540 )
2017
7
Human granulocytic anaplasmosis acquired in Connecticut, USA, diagnosed in Vienna, Austria, 2015. ( 26778486 )
2016
8
The risk of exposure to rickettsial infections and human granulocytic anaplasmosis associated with Ixodes ricinus tick bites in humans in Romania: A multiannual study. ( 28063832 )
2016
9
Accuracy of Diagnosis of Human Granulocytic Anaplasmosis in China. ( 27648639 )
2016
10
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review. ( 27115378 )
2016
11
Human Granulocytic Anaplasmosis and Lyme Disease. ( 27380349 )
2016
12
Human Granulocytic Anaplasmosis and Lyme Disease--Reply. ( 27380351 )
2016
13
Pediatric Human Granulocytic Anaplasmosis is Rare in Europe. ( 26866855 )
2016
14
Clinical and laboratory features parameters of human granulocytic anaplasmosis (HGA) in patients admitted to hospital in Guangdong Province, China. ( 25873582 )
2015
15
Comparison of clinical and laboratory characteristics of patients fulfilling criteria for proven and probable human granulocytic anaplasmosis. ( 26432519 )
2015
16
Pseudo-Pelger-HuA<t anomaly and granulocytic dysplasia associated with human granulocytic anaplasmosis. ( 25749661 )
2015
17
Human Granulocytic Anaplasmosis in the United States from 2008 to 2012: A Summary of National Surveillance Data. ( 25870428 )
2015
18
Assessing the risk of human granulocytic anaplasmosis and lyme borreliosis after a tick bite in Bavaria, Germany. ( 26338146 )
2015
19
Human granulocytic anaplasmosis. ( 25999228 )
2015
20
Acute respiratory distress syndrome in human granulocytic ehrlichiosis. ( 25672061 )
2014
21
Human granulocytic anaplasmosis acquired in Scotland, 2013. ( 24857681 )
2014
22
Diagnosis of human granulocytic anaplasmosis in Belgium by combining molecular and serological methods. ( 25566398 )
2014
23
Do leukoreduction filters passively reduce the transmission risk of human granulocytic anaplasmosis? ( 25556513 )
2014
24
Human granulocytic anaplasmosis, South Korea, 2013. ( 25271737 )
2014
25
High seroprevalence of Borrelia miyamotoi antibodies in forestry workers and individuals suspected of human granulocytic anaplasmosis in the Netherlands. ( 25356364 )
2014
26
Lyme disease and human granulocytic anaplasmosis coinfection: impact of case definition on coinfection rates and illness severity. ( 23042964 )
2013
27
Differences and similarities between culture-confirmed human granulocytic anaplasmosis and early lyme disease. ( 23303504 )
2013
28
Human granulocytic Anaplasmosis, Japan. ( 23460988 )
2013
29
Borrelia miyamotoi infection presenting as human granulocytic anaplasmosis: a case report. ( 23817701 )
2013
30
Rare neurological presentation of human granulocytic anaplasmosis. ( 23577610 )
2013
31
Seroepidemiological investigation of lyme disease and human granulocytic anaplasmosis among people living in forest areas of eight provinces in China. ( 23425801 )
2013
32
Human granulocytic anaplasmosis in eastern France: clinical presentation and laboratory diagnosis. ( 22321996 )
2012
33
Human granulocytic anaplasmosis. ( 23367517 )
2012
34
Emergence of human granulocytic anaplasmosis in France. ( 23182272 )
2012
35
Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis. ( 22859824 )
2012
36
Clinical findings and diagnosis in human granulocytic anaplasmosis: a case series from Massachusetts. ( 22386178 )
2012
37
Severe human granulocytic anaplasmosis transmitted by blood transfusion. ( 22841007 )
2012
38
Epidemiology and control of human granulocytic anaplasmosis: a systematic review. ( 22217177 )
2012
39
A case report of human granulocytic anaplasmosis (ehrlichiosis) in pregnancy and a literature review of tick-borne diseases in the United States during pregnancy. ( 22192463 )
2011
40
The clinical characteristics and outcomes of patients with human granulocytic anaplasmosis in China. ( 22015246 )
2011
41
Expansion of the Midwestern focus for human granulocytic anaplasmosis into the region surrounding La Crosse, Wisconsin. ( 21918026 )
2011
42
First described case of human granulocytic anaplasmosis in a patient in Eastern Austria. ( 20300926 )
2010
43
First case of human granulocytic anaplasmosis from Slovakia. ( 20684497 )
2010
44
Current management of human granulocytic anaplasmosis, human monocytic ehrlichiosis and Ehrlichia ewingii ehrlichiosis. ( 19681699 )
2009
45
Concomitant human granulocytic anaplasmosis and Lyme neuroborreliosis. ( 19416290 )
2009
46
The other tick-borne diseases in New Jersey: babesiosis and human granulocytic anaplasmosis. ( 21912357 )
2009
47
Human granulocytic anaplasmosis: First reported case in Canada. ( 20808448 )
2009
48
Nosocomial transmission of human granulocytic anaplasmosis in China. ( 19017912 )
2008
49
Immune evasion and immunosuppression by Anaplasma phagocytophilum, the causative agent of tick-borne fever of ruminants and human granulocytic anaplasmosis. ( 17275372 )
2008
50
Sequential analysis of Anaplasma phagocytophilum msp2 transcription in murine and equine models of human granulocytic anaplasmosis. ( 18094110 )
2008

Variations for Human Granulocytic Anaplasmosis

Expression for Human Granulocytic Anaplasmosis

Search GEO for disease gene expression data for Human Granulocytic Anaplasmosis.

Pathways for Human Granulocytic Anaplasmosis

GO Terms for Human Granulocytic Anaplasmosis

Cellular components related to Human Granulocytic Anaplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.76 ANK1 CD40LG CXCR2 CYBB HSPD1 SELPLG
2 integral component of plasma membrane GO:0005887 9.65 CD40LG CXCR2 CYBB SELPLG TFRC
3 cell surface GO:0009986 9.02 CD40LG CXCR2 HSPD1 TFRC VAMP4
4 clathrin-coated vesicle membrane GO:0030665 8.96 TFRC VAMP4

Biological processes related to Human Granulocytic Anaplasmosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.62 CD40LG CXCR2 HSPD1 RIPK2
2 positive regulation of interleukin-6 production GO:0032755 9.46 HSPD1 RIPK2
3 inflammatory response GO:0006954 9.46 CD40LG CXCR2 CYBB RIPK2
4 positive regulation of interferon-gamma production GO:0032729 9.43 HSPD1 RIPK2
5 receptor internalization GO:0031623 9.4 CXCR2 TFRC
6 B cell proliferation GO:0042100 9.37 CD40LG HSPD1
7 positive regulation of interleukin-10 production GO:0032733 9.26 CD40LG HSPD1
8 positive regulation of interferon-alpha production GO:0032727 8.96 HSPD1 RIPK2
9 positive regulation of interleukin-12 production GO:0032735 8.8 CD40LG HSPD1 RIPK2

Sources for Human Granulocytic Anaplasmosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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