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HHV8S
MCID: HMN032
MIFTS: 48

Human Herpesvirus 8 (HHV8S)

Categories: Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Human Herpesvirus 8

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MalaCards integrated aliases for Human Herpesvirus 8:

Name: Human Herpesvirus 8 57 6
Human Herpesvirus 8, Susceptibility to 57 13
Hhv-8, Susceptibility to 57
Kaposi Sarcoma 71
Hhv8s 57
Hhv-8 57
Hhv8 48

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM® 57 614836
UMLS 71 C0036220
Sources

Summaries for Human Herpesvirus 8

About this section
OMIM® : 57 Human herpesvirus-8 (HHV-8) is the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman disease (Pedergnana et al., 2012). See 148000 for general phenotypic information on these diseases, as well as information on HHV-8-associated pathogenesis. (614836) (Updated 05-Mar-2021)

MalaCards based summary : Human Herpesvirus 8, also known as human herpesvirus 8, susceptibility to, is related to kaposi sarcoma and castleman disease, and has symptoms including pruritus and exanthema. An important gene associated with Human Herpesvirus 8 is HHV8S (Human Herpesvirus 8, Susceptibility To), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vincristine and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, skin and liver, and related phenotypes are cellular and neoplasm

Sources

Related Diseases for Human Herpesvirus 8

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Diseases in the Human Herpesvirus 8 family:

Human Herpesvirus 8-Related Disorder

Diseases related to Human Herpesvirus 8 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)
# Related Disease Score Top Affiliating Genes
1 kaposi sarcoma 32.4 IL6ST IL6R IL6 IFNA1
2 castleman disease 32.0 IL6ST IL6R IL6
3 acquired immunodeficiency syndrome 30.7 IL6 IFNA1 BCL6
4 chickenpox 30.2 IL6 IFNA1
5 immune deficiency disease 30.0 IL6 IFNA1 EIF2AK2 CD209 BCL6
6 lymphoma, non-hodgkin, familial 29.8 IL6R IL6 BCL6 BCL2
7 plasmacytoma 29.8 IL6ST IL6R IL6
8 intravascular large b-cell lymphoma 29.8 BCL6 BCL2
9 primary central nervous system lymphoma 29.8 BCL6 BCL2
10 gastric lymphoma 29.6 BCL6 BCL2
11 diffuse large b-cell lymphoma 29.5 IL6 BCL6 BCL2
12 burkitt lymphoma 29.5 IL6 IFNA1 BCL6 BCL2
13 disease by infectious agent 29.4 IL6 IFNA1 CD209
14 stomatitis 29.4 IL6 IFNA1 EIF2AK2
15 viral infectious disease 29.0 IL6 IFNA1 EIF2AK2 CD209
16 leukemia, chronic lymphocytic 28.9 IL6 IFNA1 BCL6 BCL2
17 multicentric castleman disease 11.6
18 hhv-8-associated multicentric castleman disease 11.3
19 human herpesvirus 8-related disorder 11.3
20 immunodeficiency 16 11.3
21 plasmablastic lymphoma 11.2
22 sarcoma 11.2
23 spindle cell sarcoma 11.2
24 lymphoma aids related 11.0
25 lymphoma 10.8
26 human immunodeficiency virus type 1 10.8
27 b-cell lymphoma 10.7
28 myeloma, multiple 10.6
29 angiosarcoma 10.5
30 lymphoproliferative syndrome 10.5
31 syphilis 10.5
32 pemphigus 10.4
33 sarcoidosis 1 10.4
34 lymphoma, hodgkin, classic 10.4
35 hepatitis c virus 10.3
36 pulmonary hypertension 10.3
37 anaplastic large cell lymphoma 10.3
38 severe combined immunodeficiency 10.3
39 herpes simplex 10.3
40 cytokine deficiency 10.3
41 pulmonary hypertension, primary, 1 10.3
42 exanthem 10.3
43 inflammatory myofibroblastic tumor 10.3
44 hemangioma 10.3
45 human immunodeficiency virus infectious disease 10.3
46 monoclonal gammopathy of uncertain significance 10.3
47 splenomegaly 10.3
48 pemphigus vulgaris, familial 10.2
49 retinoblastoma 10.2
50 mycosis fungoides 10.2

Graphical network of the top 20 diseases related to Human Herpesvirus 8:



Diseases related to Human Herpesvirus 8
Sources

Symptoms & Phenotypes for Human Herpesvirus 8

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Clinical features from OMIM®:

614836 (Updated 05-Mar-2021)

UMLS symptoms related to Human Herpesvirus 8:


pruritus, exanthema

MGI Mouse Phenotypes related to Human Herpesvirus 8:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 BCL2 BCL6 EIF2AK2 IL6 IL6R IL6ST
2 neoplasm MP:0002006 9.02 BCL2 EIF2AK2 IL6 IL6R IL6ST
Sources

Drugs & Therapeutics for Human Herpesvirus 8

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Drugs for Human Herpesvirus 8 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 142)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
2
Bleomycin Approved, Investigational Phase 4 11056-06-7 5360373
3
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
4
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
5
Lopinavir Approved Phase 4 192725-17-0 92727
6
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
7
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
8
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
9
Nevirapine Approved Phase 4 129618-40-2 4463
10
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
11 Anti-Retroviral Agents Phase 4
12 HIV Protease Inhibitors Phase 4
13
protease inhibitors Phase 4
14 Anti-HIV Agents Phase 4
15 Reverse Transcriptase Inhibitors Phase 4
16 Antimetabolites Phase 4
17
Liposomal doxorubicin Phase 4 31703
18 Cytochrome P-450 CYP3A Inhibitors Phase 4
19 Cytochrome P-450 Enzyme Inhibitors Phase 4
20 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4
21
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
22
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
23
Ritonavir Approved, Investigational Phase 2, Phase 3 155213-67-5 392622
24
Abacavir Approved, Investigational Phase 2, Phase 3 136470-78-5 65140 441300
25 Albumin-Bound Paclitaxel Phase 3
26 Antimitotic Agents Phase 3
27 Tubulin Modulators Phase 3
28 Antibiotics, Antitubercular Phase 3
29 Anti-Bacterial Agents Phase 3
30 Dideoxynucleosides Phase 2, Phase 3
31
Etoposide Approved Phase 2 33419-42-0 36462
32
Nicotine Approved Phase 2 54-11-5 942 89594
33
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
34
Indinavir Approved Phase 2 150378-17-9 5362440
35
Bevacizumab Approved, Investigational Phase 2 216974-75-3
36
Vinblastine Approved Phase 2 865-21-4 13342 241903
37
Saquinavir Approved, Investigational Phase 2 127779-20-8 60787
38
Mitoxantrone Approved, Investigational Phase 2 65271-80-9 4212
39
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795 449171
40
Bexarotene Approved, Investigational Phase 2 153559-49-0 82146
41
Didanosine Approved Phase 2 69655-05-6 50599
42
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
43
Lenograstim Approved, Investigational Phase 2 135968-09-1
44
Cidofovir Approved Phase 2 113852-37-2 60613
45
Ixazomib Approved, Investigational Phase 2 1072833-77-2
46
Altretamine Approved Phase 2 645-05-6 2123
47
nivolumab Approved Phase 2 946414-94-4
48
Nelfinavir Approved Phase 2 159989-64-7 64143
49
Ipilimumab Approved Phase 2 477202-00-9
50
Pembrolizumab Approved Phase 2 1374853-91-4

Interventional clinical trials:

(show top 50) (show all 111)
# Name Status NCT ID Phase Drugs
1 A Randomized Comparison of Protease Inhibitor-based Versus Non-nucleoside Reverse Transcriptase Inhibitor-based Antiretroviral Therapy for Initial Treatment of Individuals With AIDS-related Kaposi's Sarcoma in Sub-Saharan Africa Completed NCT00444379 Phase 4 Lopinavir/ritonavir plus Emtricitabine/Tenofovir versus Efavirenz plus Emtricitabine/Tenofovir
2 A Prospective Randomized Trial Comparing the Response of HIV Kaposi's Sarcoma (KS) to HAART Versus the Combination of HAART and Chemotherapy (CXT) Completed NCT00380770 Phase 4 Generic HAART Triomune : d4T, 3TC, NVP;Generic HAART Triomune : d4T, 3TC, NVP and chemotherapy ABV
3 Clinical and Virologic Response to HHV-8 Associated Multicentric Castleman's Disease to Valganciclovir Withdrawn NCT00361933 Phase 4 Valganciclovir
4 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Adriamycin, Bleomycin, and Vincristine (ABV) in the Treatment of Severe AIDS-Related Kaposi's Sarcoma Unknown status NCT00002318 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
5 Phase III Study of Paclitaxel Versus Liposomal Doxorubicin for the Treatment of Advanced AIDS-Associated Kaposi's Sarcoma Completed NCT00003350 Phase 3 paclitaxel;pegylated liposomal doxorubicin hydrochloride
6 A Pilot Study Of the Effects of Highly Active Antiretroviral Therapy on Kaposi's Sarcoma in Zimbabwe Completed NCT00834457 Phase 2, Phase 3 abacavir/3TC/zidovudine;abacavir /3TC plus ritonavir boosted lopinavir
7 Double-Blind Randomized Evaluation of Clinical Benefits of DOXIL in Patients With AIDS-Related Kaposi's Sarcoma Treated With DOXIL or DaunoXome Completed NCT00002985 Phase 3 daunorubicin hydrochloride;pegylated liposomal doxorubicin hydrochloride
8 A Randomized Phase III Clinical Trial of Daunoxome Versus Combination Chemotherapy With Adriamycin/Bleomycin/Vincristine (ABV) in the Treatment of HIV-Associated Kaposi's Sarcoma. Completed NCT00002093 Phase 3 Daunorubicin (liposomal);Bleomycin sulfate;Vincristine sulfate;Doxorubicin hydrochloride
9 A Phase III Randomized Placebo Controlled and Double Blinded Study of IM862 for Patients With Muco-Cutaneous AIDS Associated Kaposi's Sarcoma Completed NCT00002445 Phase 3 IM862
10 Randomized, Comparative Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) Versus Bleomycin and Vincristine in the Treatment of AIDS-Related Kaposi's Sarcoma Completed NCT00002105 Phase 3 Doxorubicin hydrochloride (liposomal);Bleomycin sulfate;Vincristine sulfate
11 A Placebo-Controlled Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS-Associated Kaposi's Sarcoma Completed NCT00000994 Phase 3 Zidovudine
12 Use of Stealth Liposomal Doxorubicin HCl ( DOX-SL ) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma. Completed NCT00002147 Phase 3 Doxorubicin hydrochloride (liposomal)
13 Open Trial of DOX-SL (Stealth Liposomal Doxorubicin Hydrochloride) in the Treatment of Moderate to Severe AIDS-Related Kaposi's Sarcoma Completed NCT00002319 Phase 3 Doxorubicin hydrochloride (liposomal)
14 Treatment of HIV-Related Kaposi's Sarcoma and Stage I-III Slow-Proliferative Disease With Highly Active Antiretroviral Therapy (HAART) Unknown status NCT00003419 Phase 2
15 Suppression of Oral Shedding of Human Herpesvirus 8 (HHV-8) With Valganciclovir Completed NCT00194467 Phase 2 valganciclovir;placebo
16 Pilot Study of Tocilizumab in Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV) - Associated Multicentric Castleman Disease Completed NCT01441063 Phase 2 Zidovudine;Tocilizumab;Valganciclovir (VGC)
17 Treatment of Classical Kaposi Sarcoma With Nicotine Dermal Patch: A Phase II Trial Completed NCT00295984 Phase 2 nicotine
18 A Phase I/II Study of Lenalidomide in Patients With AIDS-Associated Kaposi's Sarcoma Completed NCT01057121 Phase 1, Phase 2 Lenalidomide
19 A Phase II Trial of Topical Halofuginone in Patients With HIV Related Kaposi's Sarcoma Completed NCT00064142 Phase 2 halofuginone hydrobromide
20 Phase I/II Pilot Study of Interleukin-12 in Patients With AIDS-Associated Kaposi's Sarcoma Completed NCT00019188 Phase 1, Phase 2 interleukin-12
21 An Open-Label Pilot Phase 2 Study to Investigate Efficacy, Safety, and Intratumoral Kinetics of ALDOXORUBICIN in HIV-Infected Patients With Kaposi's Sarcoma Completed NCT02029430 Phase 2 aldoxorubicin
22 A Phase II Trial With the HIV Protease Inhibitor Indinavir for the Treatment of Classical Kaposi's Sarcoma Completed NCT00362310 Phase 2 indinavir
23 Phase II Study of Intravenous Recombinant Humanized Anti-Vascular Endothelial Cell Growth Factor Antibody (Bevacizumab) in Classical (HIV-Negative) and in AIDS-Associated Kaposi's Sarcoma Completed NCT00055237 Phase 2
24 Phase II Trial for the Treatment of Advanced Classical Kaposi's Sarcoma With the HIV Protease Inhibitor Indinavir in Combination With Chemotherapy Completed NCT01067690 Phase 2 Indinavir in association with Vinblastina +/- Bleomicina
25 Evaluation of Technetium Tc 99m Tilmanocept Localization, Retention, and Distribution in Primary Cutaneous Kaposi's Sarcoma (KS) and Lymphatic Drainage From KS Lesions by SPECT/CT Imaging. Completed NCT02201420 Phase 2 Tc 99m tilmanocept
26 Pilot Study to Evaluate the Potential Interactions Between Paclitaxel and Protease Inhibitors in Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00003008 Phase 2 indinavir sulfate;nelfinavir mesylate;paclitaxel;ritonavir;saquinavir mesylate
27 Phase II Study of Intravenous Novantrone(R) in the Treatment of AIDS Related Kaposi's Sarcoma Completed NCT00002259 Phase 2 Mitoxantrone hydrochloride
28 Phase II Evaluation of Targretin Capsules in Patients With AIDS-Related Kaposi's Sarcoma Completed NCT00002212 Phase 2 Bexarotene
29 A Phase II Safety and Activity Study of Ritonavir in the Treatment of HIV-Associated Cutaneous Kaposi's Sarcoma Completed NCT00002366 Phase 2 Ritonavir
30 Comparison Study of Liposomal Doxorubicin With or Without Bleomycin and Vincristine for the Treatment of Advanced AIDS-Associated Kaposi's Sarcoma Completed NCT00001059 Phase 2 Doxorubicin hydrochloride (liposomal);Filgrastim;Bleomycin sulfate;Vincristine sulfate
31 Phase II Study of Weekly Doxorubicin Treatment of AIDS Associated Kaposi's Sarcoma Completed NCT00000996 Phase 2 Doxorubicin hydrochloride
32 A Phase I-II Trial Of BMS-275291 In Patients With HIV-Related Kaposi's Sarcoma Completed NCT00024024 Phase 1, Phase 2 rebimastat
33 A Phase II Study of Liposomal Doxorubicin and Interleukin-12 in AIDS-Associated Kaposi's Sarcoma Followed by Chronic Administration of Interleukin-12 Completed NCT00020449 Phase 2 paclitaxel;pegylated liposomal doxorubicin hydrochloride
34 A Phase II Study of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV-Related Kaposi's Sarcoma Completed NCT00002314 Phase 2 Ro 24-7429
35 Phase II Evaluation of Oral ALRT1057 in Patients With AIDS-Related Kaposi's Sarcoma. Completed NCT00002188 Phase 2 Alitretinoin
36 A Randomized Phase II Trial to Determine the Safety, Tolerance, and Efficacy of Two Doses of Interferon Alfa-2b Combined With Didanosine in Patients With Kaposi's Sarcoma Completed NCT00001114 Phase 2 Interferon alfa-2b;Didanosine
37 A Phase II Trial Of Imatinib Mesylate (Gleevec) In Patients With HIV Related Kaposi's Sarcoma Completed NCT00090987 Phase 2 imatinib mesylate
38 A Multicenter, Open-Label, Phase II Study of SU5416 in Patients With Cutaneous AIDS-Related Kaposi's Sarcoma Completed NCT00005042 Phase 2 semaxanib
39 PHASE II PROTOCOL WITH LABORATORY CORRELATES OF 1-[(S)-3-HYDROXY-2-(PHOSPHOMETHOXY)PROPYL]CYTOSINE DIHYDRATE(CIDOFOVIR) IN PATIENTS WITH KAPOSI'S SARCOMA (KS) Completed NCT00019240 Phase 2 cidofovir
40 A PHASE II STUDY OF ORAL THALIDOMIDE FOR PATIENTS WITH HIV INFECTION AND KAPOSI'S SARCOMA Completed NCT00019123 Phase 2 thalidomide
41 A Multicenter, Open-Label, Phase II Study of SU5416 in Patients With Therapy-Refractory Cutaneous AIDS-Related Kaposi's Sarcoma Completed NCT00005931 Phase 2 SU5416
42 A Pilot Study of OPC-8212 (Vesnarinone) in Persons With AIDS-Related Kaposi's Sarcoma Completed NCT00002131 Phase 2 Vesnarinone
43 Paclitaxel in Advanced Refractory Kaposi's Sarcoma (AIDS-KS): A Phase II Trial of Paclitaxel From Baker Norton Pharmaceuticals Completed NCT00002189 Phase 2 Paclitaxel
44 Photodynamic Therapy Clinical Trial For Cutaneous AIDS-Related Kaposi's Sarcoma Study Summary. Completed NCT00002167 Phase 2 Tin ethyl etiopurpurin
45 Phase II Study of Zidovudine and Recombinant Alpha-2A Interferon in the Treatment of Patients With AIDS-Associated Kaposi's Sarcoma Completed NCT00000687 Phase 2 Interferon alfa-2a;Zidovudine
46 Phase II Evaluation of Low-Dose Oral Etoposide for the Treatment of Relapsed or Progressed AIDS-Related Kaposi's Sarcoma After Systemic Chemotherapy Completed NCT00000807 Phase 2 Etoposide
47 A Phase 2 Trial of Ixazomib for Kaposi Sarcoma Recruiting NCT04305691 Phase 2 Ixazomib Citrate
48 A Phase II Study of sEphB4-HSA in Kaposi Sarcoma Recruiting NCT02799485 Phase 2
49 Phase I/II of NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma Recruiting NCT04303117 Phase 1, Phase 2 NHS-IL12;M7824
50 A Phase II Multicenter Study of Pomalidomide Monotherapy in HIV-Positive Individuals With Kaposi Sarcoma (KS) in Sub-Saharan Africa (SSA) Recruiting NCT03601806 Phase 2 Pomalidomide

Search NIH Clinical Center for Human Herpesvirus 8

Inferred drug relations via UMLS 71 / NDF-RT 51 :


alitretinoin
doxorubicin hydrochloride liposome
Etoposide
etoposide phosphate
Interferon Alfa-2a
Interferon Alfa-2b
INTERFERON ALFA-3N,HUMAN LEUKOCYTE DERIVED
interferon alfacon-1
Interferon gamma-1b
Interferons
Paclitaxel
peginterferon alfa-2a
peginterferon alfa-2b
Recombinant interferon beta-1a
Recombinant interferon beta-1b
Vinblastine
Vinblastine Sulfate
Sources

Genetic Tests for Human Herpesvirus 8

About this section
Sources

Anatomical Context for Human Herpesvirus 8

About this section

MalaCards organs/tissues related to Human Herpesvirus 8:

40
Endothelial, Skin, Liver, Bone, Bone Marrow, Kidney, Lymph Node
Sources

Publications for Human Herpesvirus 8

About this section

Articles related to Human Herpesvirus 8:

(show top 50) (show all 2296)
# Title Authors PMID Year
1
A major locus on chromosome 3p22 conferring predisposition to human herpesvirus 8 infection. 57 61
22258534 2012
2
Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. 6
17623760 2007
3
Interleukin-6 involvement in brain arteriovenous malformations. 6
16278864 2006
4
Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children. 6
16150725 2005
5
Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations. 6
15331795 2004
6
Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes. 6
15472205 2004
7
Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. 6
15070960 2004
8
Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. 6
12719374 2003
9
The interleukin 6-174G/C polymorphism is associated with indices of obesity in men. 6
12560873 2003
10
Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. 6
12519862 2003
11
The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism. 6
11889177 2002
12
An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus. 6
11001912 2000
13
Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. 6
10720087 2000
14
The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. 6
9769329 1998
15
Epithelioid Kaposi Sarcoma: A New Histological Variant. 61
33464749 2021
16
Donor-derived human herpesvirus 8 and development of Kaposi sarcoma among 6 recipients of organs from donors with high-risk sexual and substance use behavior. 61
32633035 2021
17
Primary nasal Kaposi Sarcoma in well-controlled HIV-positive patient with normal CD4 count associated with long-term nasal steroid use. 61
33533293 2021
18
Elevated IL-13 in effusions of patients with HIV and primary effusion lymphoma as compared with other Kaposi sarcoma herpesvirus-associated disorders. 61
33273183 2021
19
Novel Functions and Virus-Host Interactions Implicated in Pathogenesis and Replication of Human Herpesvirus 8. 61
33200369 2021
20
Extensive cutaneous iatrogenic Kaposi's sarcoma after bullous pemphigoid treatment with oral methylprednisolone: a rare Chinese case report. 61
33496629 2021
21
Human herpesvirus-8-positive primary effusion lymphoma in HIV-negative patients: Single institution case series with a multidisciplinary characterization. 61
32975904 2021
22
Iatrogenic Kaposi's sarcoma in myasthenia gravis: learnings from two case reports. 61
33404862 2021
23
Epidemiology and Genetic Variability of HHV-8/KSHV among Rural Populations and Kaposi's Sarcoma Patients in Gabon, Central Africa. Review of the Geographical Distribution of HHV-8 K1 Genotypes in Africa. 61
33503816 2021
24
Concurrent development of HIV-negative Kaposi's sarcoma and mycosis fungoides in an elderly Inuit from Canada. 61
33509877 2021
25
Seroprevalence of human herpesvirus 8 in Ireland among blood donors, men who have sex with men and heterosexual Genitourinary Medicine and Infectious Diseases clinic attendees. 61
33475183 2021
26
Kaposi Sarcoma With Intravascular Primary Effusion Lymphoma in the Skin: A Potential Pitfall in HHV8 Immunohistochemistry Interpretation. 61
32460596 2020
27
Human herpesvirus 8-negative effusion-based lymphoma with indolent clinical behavior in an elderly patient: A case report and literature review. 61
33123254 2020
28
Seroepidemiology of the human herpesvirus 8 infection among people living with HIV in Taiwan, 2014-2018. 61
33349600 2020
29
Oncogenic viruses and cancer 61
33470075 2020
30
International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease. 61
33284946 2020
31
Kaposi sarcoma in a child after hematopoietic stem cell transplantation: Should pre-transplant HHV-8 screening be considered in recipients from high prevalence areas? 61
33231901 2020
32
Two cases of rare HHV8-driven intravascular lymphoma with synchronous Kaposi sarcoma, both diagnosed at autopsy in renal transplant recipients. 61
33344322 2020
33
Pyogenic granuloma-like Kaposi sarcoma presenting in an HIV-negative man who has sex with men. 61
33257381 2020
34
Italian guidelines for the diagnosis and treatment of classic and iatrogenic Kaposi's sarcoma. 61
33179877 2020
35
Idiopathic multicentric Castleman disease preceded by cutaneous plasmacytosis successfully treated by tocilizumab. 61
33148595 2020
36
A Novel Predictive Model for Idiopathic Multicentric Castleman Disease: The International Castleman Disease Consortium Study. 61
32852137 2020
37
Racial/Ethnic Differences in Cancers Attributable to Preventable Infectious Agents in Texas, 2015. 61
33080142 2020
38
Germinotropic lymphoproliferative disorder: a systematic review. 61
32307569 2020
39
Infiltrating Kaposi sarcoma presenting as acute kidney injury: An unexpected consequence of deliberate hepatitis C-positive organ transplantation. 61
33012057 2020
40
Tonsillar Kaposi sarcoma in a renal transplant patient. 61
32495980 2020
41
High abundance of human herpesvirus 8 in wastewater from a large urban area. 61
33058412 2020
42
Identification of multiple potential viral diseases in a large urban center using wastewater surveillance. 61
32738707 2020
43
Elevated IL-13 in effusions of patients with HIV and primary effusion lymphoma as compared with other KSHV-associated disorders. 61
32947593 2020
44
Cytokine-Targeted Therapeutics for KSHV-Associated Disease. 61
32998419 2020
45
Genetic Analyses of Contributions of Viral Interleukin-6 Interactions and Signaling to Human Herpesvirus 8 Productive Replication. 61
32669340 2020
46
Primary human herpesvirus 8-negative effusion-based lymphoma: a large B-cell lymphoma with favorable prognosis. 61
32936906 2020
47
Human herpesvirus 8-positive multicentric Castleman disease with germinotropic plasmablastic aggregates: Overlapping spectrum of human herpesvirus 8-associated lymphoproliferative disorder. 61
32449234 2020
48
Intravascular lymphoma presenting with paraneoplastic syndrome. 61
32941715 2020
49
Update on Kaposi sarcoma-associated herpesvirus (HHV8) - review. 61
32681788 2020
50
Human herpes virus 8 antibodies in HIV-positive patients in Surabaya, Indonesia. 61
32874472 2020
Sources

Variations for Human Herpesvirus 8

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ClinVar genetic disease variations for Human Herpesvirus 8:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 IL6 IL6, -174G-C SNV risk factor 14718
Sources

Expression for Human Herpesvirus 8

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Search GEO for disease gene expression data for Human Herpesvirus 8.
Sources

Pathways for Human Herpesvirus 8

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Pathways related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.76 IL6ST IL6R IL6 IFNA1 EIF2AK2 CD209
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.98 IL6ST IL6R IL6 IFNA1 EIF2AK2 BCL6
3
PI3K-Akt signaling pathway 36
Show member pathways
 12.77 IL6R IL6 IFNA1 EIF2AK2 BCL2
4
Pathways in cancer 36
12.6 IL6ST IL6R IL6 IFNA1 BCL2
5
Herpes simplex virus 1 infection 36
12.59 IL6 IFNA1 EIF2AK2 BCL2
6
Measles 36
Show member pathways
 12.56 IL6 IFNA1 EIF2AK2 CD209 BCL2
7
Th17 cell differentiation 36
Show member pathways
 12.41 IL6ST IL6R IL6 BCL2
8
IL-17 Family Signaling Pathways 64
Show member pathways
 12.14 IL6ST IL6R IL6
9
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.13 IL6ST IL6R IL6
10
Translation Non-genomic (rapid) action of Androgen Receptor 23
Show member pathways
 12.11 IL6ST IL6R IL6
11
Autophagy Pathway 66
12.07 IL6ST IL6R BCL2
12
NOD-like receptor signaling pathway 36
12.04 IL6 IFNA1 BCL2
13
Necroptosis 36
Show member pathways
 12 IFNA1 EIF2AK2 BCL2
14
Tuberculosis 36
11.99 IL6 IFNA1 CD209 BCL2
15
Human cytomegalovirus infection 36
Show member pathways
 11.97 IL6ST IL6R IL6 IFNA1 EIF2AK2 CD200R1
16
HIF-1 signaling pathway 36
11.79 IL6R IL6 BCL2
17
JAK-STAT signaling pathway 36
Show member pathways
 11.75 IL6ST IL6R IL6 IFNA1 BCL2
18
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.7 IL6ST IL6R IL6
19
Th17 Differentiation Pathway 64
Show member pathways
 11.68 IL6ST IL6R IL6
20
IL6-mediated signaling events 1
Show member pathways
 11.63 IL6ST IL6R IL6
21
Interleukin-4 and 13 signaling 65
11.61 IL6R IL6 BCL6 BCL2
22
Senescence and Autophagy in Cancer 1
11.48 IL6ST IL6R IL6 BCL2
23
Interleukin-6 family signaling 65
Show member pathways
 11.43 IL6ST IL6R IL6
24
RAF-independent MAPK1/3 activation 65
Show member pathways
 11.2 IL6ST IL6R IL6
25
Immune response_IL-6 signaling pathway 23
11.06 IL6ST IL6R IL6
26
Overview of nanoparticle effects 1
10.86 IL6 BCL2
Sources

GO Terms for Human Herpesvirus 8

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Cellular components related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 IL6ST IL6R CD209 CD200R1
2 receptor complex GO:0043235 9.43 IL6ST IL6R CD200R1
3 ciliary neurotrophic factor receptor complex GO:0070110 8.96 IL6ST IL6R
4 interleukin-6 receptor complex GO:0005896 8.8 IL6ST IL6R IL6

Biological processes related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.93 IL6ST EIF2AK2 CD209 CD200R1
2 negative regulation of cell proliferation GO:0008285 9.92 IL6 EIF2AK2 BCL6 BCL2
3 positive regulation of cell proliferation GO:0008284 9.89 NAP1L1 IL6ST IL6R IL6 BCL2
4 negative regulation of apoptotic process GO:0043066 9.88 IL6ST IL6 EIF2AK2 BCL6 BCL2
5 B cell differentiation GO:0030183 9.74 IFNA1 BCL6 BCL2
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 IL6ST IL6R IL6
7 positive regulation of osteoblast differentiation GO:0045669 9.7 IL6ST IL6R IL6
8 positive regulation of T cell proliferation GO:0042102 9.69 IL6ST IL6 CD209
9 defense response to virus GO:0051607 9.67 IL6 IFNA1 EIF2AK2 BCL2
10 B cell proliferation GO:0042100 9.64 IFNA1 BCL2
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.63 IL6ST IL6
12 endocrine pancreas development GO:0031018 9.62 IL6R IL6
13 negative regulation of collagen biosynthetic process GO:0032966 9.61 IL6R IL6
14 negative regulation of osteoblast proliferation GO:0033689 9.61 EIF2AK2 BCL2
15 response to cytokine GO:0034097 9.61 IL6ST IL6R BCL2
16 positive regulation of leukocyte chemotaxis GO:0002690 9.6 IL6R IL6
17 positive regulation of acute inflammatory response GO:0002675 9.59 IL6ST IL6
18 regulation of neuroinflammatory response GO:0150077 9.58 IL6 CD200R1
19 neutrophil mediated immunity GO:0002446 9.58 IL6R IL6
20 humoral immune response GO:0006959 9.58 IL6 IFNA1 BCL2
21 T-helper 17 cell lineage commitment GO:0072540 9.56 IL6R IL6
22 vascular endothelial growth factor production GO:0010573 9.55 IL6R IL6
23 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 9.46 IL6ST IL6R
24 positive regulation of chemokine production GO:0032722 9.43 IL6R IL6 EIF2AK2
25 interleukin-11-mediated signaling pathway GO:0038154 9.32 IL6ST IL6R
26 hepatic immune response GO:0002384 9.16 IL6R IL6
27 interleukin-6-mediated signaling pathway GO:0070102 9.13 IL6ST IL6R IL6
28 cytokine-mediated signaling pathway GO:0019221 9.1 IL6ST IL6R IL6 IFNA1 BCL6 BCL2

Molecular functions related to Human Herpesvirus 8 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ciliary neurotrophic factor receptor activity GO:0004897 9.37 IL6ST IL6R
2 interleukin-11 binding GO:0019970 9.32 IL6ST IL6R
3 interleukin-11 receptor activity GO:0004921 9.26 IL6ST IL6R
4 interleukin-6 binding GO:0019981 9.16 IL6ST IL6R
5 interleukin-6 receptor activity GO:0004915 8.96 IL6ST IL6R
6 interleukin-6 receptor binding GO:0005138 8.8 IL6ST IL6R IL6
Sources

Sources for Human Herpesvirus 8

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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