Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: HMN014
MIFTS: 62

Human Immunodeficiency Virus Infectious Disease

Categories: Immune diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Human Immunodeficiency Virus Infectious Disease

About this section

MalaCards integrated aliases for Human Immunodeficiency Virus Infectious Disease:

Name: Human Immunodeficiency Virus Infectious Disease 12 15
Hiv Infection 15 17

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:526
ICD9CM 36 042 042-042.99
MeSH 45 D015658
NCIt 51 C3108
SNOMED-CT 69 86406008
ICD10 34 B20 B20-B20
UMLS 74 C0019693
Sources

Summaries for Human Immunodeficiency Virus Infectious Disease

About this section
Disease Ontology : 12 A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.

MalaCards based summary : Human Immunodeficiency Virus Infectious Disease, also known as hiv infection, is related to aids dementia complex and human immunodeficiency virus type 1. An important gene associated with Human Immunodeficiency Virus Infectious Disease is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ribavirin and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and liver, and related phenotypes are hematopoietic system and digestive/alimentary

Sources

Related Diseases for Human Immunodeficiency Virus Infectious Disease

About this section

Diseases related to Human Immunodeficiency Virus Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1039)
# Related Disease Score Top Affiliating Genes
1 aids dementia complex 32.8 B2M CXCR4 ITIH4 TNF
2 human immunodeficiency virus type 1 32.0 APOBEC3G B2M CCL4 CCL5 CCR5 CD28
3 acquired immunodeficiency syndrome 32.0 B2M CCR5 CD38 CD4 IL2 IL6
4 meningitis 31.4 CCL4 IL6 TNF
5 pulmonary tuberculosis 31.2 CCL4 IL2 TNF
6 toxoplasmosis 31.1 CCR5 IL6 TNF
7 encephalitis 30.9 CCL5 CCR5 ERVW-1 ITIH4
8 cytomegalovirus infection 30.8 B2M CCL5 IL6 TNF
9 lymphoma, non-hodgkin, familial 30.8 B2M CD38 CXCR4 IL2
10 meningoencephalitis 30.8 B2M CCL5 IL6
11 yellow fever 30.8 CCL5 CCR5 IL6
12 bone disease 30.6 B2M CCL4 IL6 TNF
13 peritonitis 30.5 B2M IL6 TNF
14 exanthem 30.4 IL2 IL6 TNF
15 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 30.4 APOBEC3G CCL4 CCR5 CD4 CXCR4 ERVW-1
16 brucellosis 30.4 IL2 IL6 TNF
17 myocardial infarction 30.4 CCL5 CCR5 CXCR4 IL6 S100B TNF
18 bronchiolitis 30.4 CCL5 IL6 TNF
19 pulmonary sarcoidosis 30.3 CCL5 CCR5 IL2 TNF
20 syphilitic meningitis 30.3 ENPEP ITIH4
21 chagas disease 30.3 CCR5 IL2 IL6 TNF
22 hematopoietic stem cell transplantation 30.2 IL2 IL6 TNF
23 paracoccidioidomycosis 30.2 IL2 IL6 TNF
24 pulmonary disease, chronic obstructive 30.2 CCL5 IL6 SERPINA3 TNF
25 bacterial meningitis 30.1 IL6 S100B TNF
26 myeloma, multiple 30.1 B2M CD38 CXCR4 IL2 IL6 TNF
27 bone inflammation disease 30.1 IL2 IL6 TNF
28 oral tuberculosis 30.1 IL2 TNF
29 plasmacytoma 30.1 B2M CD38 IL2 IL6
30 monoclonal gammopathy of uncertain significance 30.1 B2M CD38 IL6 TNF
31 systemic lupus erythematosus 30.1 CCL5 CCR5 CD28 IL2 IL6 TNF
32 malaria 30.0 CCL4 CCL5 IL2 IL6 TNF
33 extramedullary plasmacytoma 30.0 B2M IL2 IL6
34 aphthous stomatitis 30.0 IL2 IL6 TNF
35 prostatitis 30.0 IL2 IL6 TNF
36 multiple sclerosis 29.9 CCL5 CCR5 ERVW-1 IL2 IL6 TNF
37 chikungunya 29.9 CCL5 IL6 TNF
38 toxic shock syndrome 29.9 IL2 IL6 TNF
39 common variable immunodeficiency 29.9 CD28 CD38 IL2 IL6 TNF
40 sleep apnea 29.9 IL6 S100B TNF
41 filariasis 29.9 CCL5 IL2 IL6 TNF
42 trypanosomiasis 29.8 CCL5 IL2 IL6 TNF
43 behcet syndrome 29.8 CCR5 IL2 IL6 TNF
44 intestinal disease 29.8 IL2 IL6 TNF
45 leukemia, chronic lymphocytic 29.7 B2M CD38 CXCR4 IL2
46 interstitial lung disease 29.7 CCL5 IL6 TNF
47 rheumatoid arthritis 29.7 CCL5 CD28 IL2 IL6 TNF
48 susceptibility/resistance to hiv infection 12.3
49 immunodeficiency 13 11.4
50 anus cancer 11.3

Graphical network of the top 20 diseases related to Human Immunodeficiency Virus Infectious Disease:



Diseases related to Human Immunodeficiency Virus Infectious Disease
Sources

Symptoms & Phenotypes for Human Immunodeficiency Virus Infectious Disease

About this section

MGI Mouse Phenotypes related to Human Immunodeficiency Virus Infectious Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 B2M CCL5 CCR5 CCR6 CD28 CD38
2 digestive/alimentary MP:0005381 9.86 B2M CCR5 CD28 CD4 CXCR4 IL2
3 immune system MP:0005387 9.73 B2M CCL5 CCR5 CCR6 CD28 CD38
4 neoplasm MP:0002006 9.23 B2M CCR5 CD28 CXCR4 IL2 IL6
Sources

Drugs & Therapeutics for Human Immunodeficiency Virus Infectious Disease

About this section

Drugs for Human Immunodeficiency Virus Infectious Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1302)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 36791-04-5 37542
2
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 6493-05-6 4740
3
Cobicistat Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1004316-88-4
4
Darunavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 206361-99-1, 635728-49-3 213039
5
Rilpivirine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 500287-72-9
6
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 136470-78-5 441300 65140
7
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 134678-17-4 60825
8
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 143491-57-0 60877
9
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52485-79-7 40400 644073
10
Lopinavir Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 192725-17-0 92727
11
Ritonavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 155213-67-5 392622
12
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3056-17-5 18283
13
Rifabutin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 72559-06-9 6323490 46783538
14
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 738-70-5 5578
15
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 723-46-6 5329
16
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 154598-52-4 64139
17
Dolutegravir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1051375-16-6 54726191
18
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 76-99-3 4095
19
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93-14-1 3516
20
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 564-25-0 54671203
21
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
22
Rifampicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 13292-46-1 5381226 5458213
23
Lumefantrine Approved Phase 4,Phase 3,Phase 1,Not Applicable 82186-77-4 6437380
24
Artemether Approved Phase 4,Phase 3,Phase 1,Not Applicable 71963-77-4 119380 68911
25
Nevirapine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 129618-40-2 4463
26
Isoniazid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 54-85-3 3767
27
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 30516-87-1 35370
28
Nelfinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 159989-64-7 64143
29
Didanosine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69655-05-6 50599
30
Amprenavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 161814-49-9 65016
31
Maraviroc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 376348-65-1 3002977
32
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
33
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
34
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
35
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
36
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
37
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
38
Ezetimibe Approved Phase 4,Phase 1,Not Applicable 163222-33-1 150311
39
Pravastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81093-37-0 54687
40
Fenofibrate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 49562-28-9 3339
41
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 198153-51-4 5360545
42
Pyrazinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 98-96-4 1046
43
Ethambutol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 74-55-5 3279 14052
44
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1397-89-3 14956 5280965
45
Alendronate Approved Phase 4,Phase 3,Phase 2 66376-36-1, 121268-17-5 2088
46
Calcium Carbonate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 471-34-1
47
Entecavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 142217-69-4 153941
48
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 28014-46-2
49
Desogestrel Approved Phase 4,Phase 2,Not Applicable 54024-22-5 40973
50
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757

Interventional clinical trials:

(show top 50) (show all 9461)
# Name Status NCT ID Phase Drugs
1 A Comparison of Virco®TYPE HIV-1 Testing Versus Expert Interpretation of Genotypic Results for Control of HIV-1 Replication Unknown status NCT00840762 Phase 4
2 Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients Unknown status NCT02008214 Phase 4 Pentoxifylline;Placebo
3 Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects Unknown status NCT02404233 Phase 4 darunavir/cobicistat;rilpivirine
4 Pilot Study With Isentress (Raltegravir) and Epzicom (Abacavir/Lamivudine) in Treatment Naive HIV-Infected Subjects Unknown status NCT00740064 Phase 4 Raltegravir and Abacavir/Lamivudine
5 HIV Persistence and Viral Reservoirs Unknown status NCT01025427 Phase 4 Raltegravir, tenofovir/emtricitabine
6 Integrating Buprenorphine Into HIV Treatment Unknown status NCT00241930 Phase 4
7 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
8 Study on the Antiviral Therapy and Immune Reconstitution of Chinese HIV/AIDS Patients Unknown status NCT00872417 Phase 4 first line ARV (3TC+NVP+D4T or 3TC+NVP+AZT);second line ARV therapy (3TC+TDF+LPV/RTV)
9 Buprenorphine and Integrated HIV Care Evaluation Unknown status NCT00124358 Phase 4 Buprenorphine
10 Raltegravir + Lamivudine/Abacavir in HIV/Tuberculosis Co-Infected Patients Unknown status NCT01059422 Phase 4 Raltegravir; Abacavir/Lamivudine
11 Efficacy and Safety of Raltegravir (RAL) in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
12 RAL+ATV/r in Comparison With TDF/FTC (or 3TC) +ATV/r in HIV Infected Patients Unknown status NCT01829802 Phase 4 Ritonavir boosted Atazanavir;Raltegravir;TDF/FTC (or 3TC)
13 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
14 Comparing a Nucleoside-Analogue-Sparing Regimen and a Protease-Inhibitor-Sparing Regimen in HIV Infected Patients Unknown status NCT00135460 Phase 4 nucleoside analogue sparing HAART regimen
15 Lopinavir/Ritonavir or Efavirenz as First-line Antiretroviral Therapy Unknown status NCT01049685 Phase 4 First-line Antiretroviral Therapy
16 The Dolutegravir Antiretroviral Mono-Therapy for HIV Trial Unknown status NCT02401828 Phase 4 Dolutegravir
17 Safety and Efficacy Study Comparing Raltegravir to a Protease Inhibitor in Treatment-naïve, HIV/Hepatitis C Drug Users Unknown status NCT01105611 Phase 4 Raltegravir;Atazanavir/Ritonavir
18 Impact of Starting a Dolutegravir-based Regimen on HIV-1 Proviral DNA Reservoir Of Treatment Naïve and Experienced Patients Unknown status NCT02370979 Phase 4
19 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Unknown status NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
20 Effect of a Non-tenofovir, Non-efavirenz-based HIV Regimen on Bone Density and Vitamin D Levels in African-American Patients With HIV Infection Unknown status NCT01343225 Phase 4 atripla;darunavir ritonavir raltegravir
21 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4 cyclosporine and sodium carboximethycellulose;sodium carboximethycellulose
22 Hepatic Safety of Raltegravir Versus Efavirenz as HIV Therapy for Patients With HIV and HCV Coinfection Unknown status NCT01147107 Phase 4 Raltegravir;Efavirenz
23 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
24 Drug Interaction Between Coartem® and Nevirapine, Efavirenz or Rifampicin in HIV Positive Ugandan Patients Unknown status NCT00620438 Phase 4 Lumefantrine-artemether and nevirapine;lumefantrine-artemether and efavirenz;Lumefantrine-artemether and rifampicin
25 Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL) Unknown status NCT01875952 Phase 4 Isoniazid
26 Immunological Memory Induced by the 13valent Pneumococcal Conjugate(PCV13) and 23valent Plain Polysaccharide Vaccine(PPV23) in HIV-infected Patients Unknown status NCT03041051 Phase 4
27 Treatment With Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs Unknown status NCT00005000 Phase 4 Nelfinavir mesylate;Efavirenz;Lamivudine;Keyhole-Limpet Hemocyanin;Stavudine;Zidovudine;Didanosine
28 Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs Unknown status NCT00011895 Phase 4 Abacavir sulfate, Lamivudine and Zidovudine;Efavirenz
29 Once Daily 3TC, Efavirenz and ddI for HIV Infection Unknown status NCT00214435 Phase 4 once daily minimum 3-drug regimen of anti-retroviral medications
30 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
31 Protease Inhibitor vs. Raltegravir-based ART and Inflammation in HIV Infection Unknown status NCT02691065 Phase 4 Integrase Inhibitor
32 Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment Unknown status NCT00005017 Phase 4 Ritonavir;Abacavir sulfate;Amprenavir;Efavirenz;Lamivudine;Stavudine
33 Maraviroc (Celsentri) With Raltegravir and Darunavir/Ritonavir for the Treatment of Triple Class Failure in Adult HIV-1 Infected Patients Unknown status NCT01013987 Phase 4 maraviroc;Raltegravir;Darunavir/ritonavir
34 Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine Unknown status NCT00564057 Phase 4 candesartan;lercanidipine
35 A Pilot Study of Triple NtRTI/NsRTI Therapy in Antiretroviral Naive HIV-1 Infected Patients Unknown status NCT00199121 Phase 4 Zidovudine (drug)
36 Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients Unknown status NCT00247494 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
37 PI Vs. NNRTI Based Therapy for HIV Advanced Disease Unknown status NCT00162643 Phase 4 zidovudine+lamivudine+lopinavir/ritonavir;zidovudine + lamivudine + efavirenz
38 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
39 Effect of Maraviroc (MCV) on the Immunological Recovery of HIV-1 Discordant Patients With CD4 Lymphocyte Counts Below 200 Cells/mm3 Unknown status NCT01235013 Phase 4 Maraviroc
40 Simplification From Protease Inhibitors to Raltegravir Unknown status NCT00941083 Phase 4 Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy)
41 RAltegravir Switch STudy: Effects on Endothelial Recovery Unknown status NCT01453933 Phase 4 raltegravir
42 Atazanavir/r + Lamivudine Dual Therapy Unknown status NCT01599364 Phase 4 Atazanavir, ritonavir, lamivudine
43 Equivalence of Boosted Atazanavir Based Regimens and Currently Effective HAART Regimens Unknown status NCT00940771 Phase 4 Boosted Atazanavir
44 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
45 Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study) Unknown status NCT00120419 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
46 Coadministration of Ezetimibe With Fenofibrate Versus Pravastatin Monotherapy for the Treatment of Hyperlipidaemia in HIV-infected Patients Unknown status NCT00843661 Phase 4 ezetimibe;fenofibrate;pravastatin
47 Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism Unknown status NCT00759070 Phase 4 Tenofovir + emtricitabine + efavirenz;Tenofovir + emtricitabine + lopinavir/ritonavir
48 Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment Unknown status NCT00751153 Phase 4 Raltegravir and Atazanavir
49 Raltegravir-based Antiretroviral Versus Maintaining Any Other Antiretroviral Therapy in HIV Mono-infected Patients Unknown status NCT02210715 Phase 4 Isentress.
50 Evaluation of Safety and Immunogenicity of a Human Papillomavirus (HPV) Vaccine in Human Immunodeficiency Virus (HIV) Infected Females Unknown status NCT01031069 Phase 4

Search NIH Clinical Center for Human Immunodeficiency Virus Infectious Disease

Sources

Genetic Tests for Human Immunodeficiency Virus Infectious Disease

About this section
Sources

Anatomical Context for Human Immunodeficiency Virus Infectious Disease

About this section

MalaCards organs/tissues related to Human Immunodeficiency Virus Infectious Disease:

42
Testes, T Cells, Liver, Bone, Kidney, Lung, Brain
Sources

Publications for Human Immunodeficiency Virus Infectious Disease

About this section

Articles related to Human Immunodeficiency Virus Infectious Disease:

(show top 50) (show all 4727)
# Title Authors Year
1
T-cell immunity against cytomegalovirus in HIV infection and aging: relationships with inflammation, immune activation, and frailty. ( 30900090 )
2019
2
Impact of aging and HIV infection on serologic response to seasonal influenza vaccination: Erratum. ( 30829752 )
2019
3
Various associations of aging and long-term HIV infection with different neurocognitive functions: detailed analysis of a Japanese nationwide multicenter study. ( 30859496 )
2019
4
HIV infection across aging: Synergistic effects on intrinsic functional connectivity of the brain. ( 29906495 )
2019
5
Treatment outcomes of patients with localized anal squamous cell carcinoma according to HIV infection: systematic review and meta-analysis. ( 30788159 )
2019
6
Hepatocellular carcinoma: Clinical-pathological features and HIV infection in Mozambican patients. ( 30903933 )
2019
7
Influence of HIV Infection on the Natural History of Hepatocellular Carcinoma: Results From a Global Multicohort Study. ( 30562130 )
2019
8
Primary central nervous system lymphoma in patients with and without HIV infection: a multicenter study and comparison with U.S national data. ( 30888569 )
2019
9
Hospital Onset Varicella Central Nervous System Vasculitis in a Patient with HIV Infection. ( 30715900 )
2019
10
Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection. ( 30907775 )
2019
11
HIV infection is not associated with the initiation of curative treatment in women with cervical cancer in Botswana. ( 30801696 )
2019
12
Refractory ascites as a presenting feature of extramedullary plasmacytoma in an end-stage renal disease patient with HIV infection. ( 30838169 )
2019
13
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in HIV infection: a metabolic approach of an infectious disease. ( 30905208 )
2019
14
The impact of HIV infection and MSM status on hepatitis A infection: the experience of two tertiary centres in Northern Italy during the 2017 outbreak and in the 2009-2016 period. ( 30801838 )
2019
15
Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV Infection Among Patients With Newly Diagnosed Cancer From Academic and Community Oncology Practices. ( 30653226 )
2019
16
Progressive disseminated histoplasmosis in Latin America and the Caribbean in people receiving highly active antiretroviral therapy for HIV infection: A systematic review. ( 30668766 )
2019
17
Short-term outcomes for lung cancer resection surgery in HIV infection. ( 30889013 )
2019
18
HIV infection compounds the lymphopenia associated with cerebral malaria in Malawian children. ( 30588141 )
2019
19
Acute purulent pericarditis due co-infection with Staphylococcus aureus and Mycobacterium tuberculosis as first manifestation of HIV infection. ( 30800325 )
2019
20
Psoriasis in HIV infection: an update. ( 30813860 )
2019
21
Challenges in the treatment of psoriasis with biologics: vaccination, history of malignancy, human immunodeficiency virus (HIV) infection, and pediatric psoriasis. ( 30891751 )
2019
22
Erythrodermic Psoriasis and HIV Infection. ( 30601728 )
2019
23
Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer's disease? ( 30868421 )
2019
24
Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease. ( 30610738 )
2019
25
Elevated Plasma Ceramides Are Associated With Antiretroviral Therapy Use and Progression of Carotid Artery Atherosclerosis in HIV Infection. ( 30759995 )
2019
26
Cardiomyopathy and Heart Failure in Patients With HIV Infection. ( 30621958 )
2019
27
Monocyte and Alveolar Macrophage Skewing Is Associated with the Development of Pulmonary Arterial Hypertension in a Primate Model of HIV Infection. ( 30229666 )
2019
28
Maternal HIV infection and preeclampsia increased risk of low birth weight among newborns delivered at University of Gondar specialized referral hospital, Northwest Ethiopia, 2017. ( 30630512 )
2019
29
Mechanisms of Arrhythmia and Sudden Cardiac Death in Patients With HIV Infection. ( 30825952 )
2019
30
MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques. ( 30777923 )
2019
31
QuickStats: Age-Adjusted Percentage* of Adults Aged ≥18 Years Who Were Ever Tested for Human Immunodeficiency Virus (HIV)† Infection, by U.S. Census Region§ - National Health Interview Survey, 2017¶. ( 30605450 )
2019
32
Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection. ( 30609219 )
2019
33
HIV infection and unknown HIV status among tuberculosis patients in Ethiopia: a systematic review and meta-analysis. ( 30808451 )
2019
34
The Impact of HIV Infection on TB Disparities Among US-Born Black and White Tuberculosis Patients in the United States. ( 30789591 )
2019
35
Seizures in Children with HIV infection in South Africa: A retrospective case control study. ( 30721872 )
2019
36
Plasma acylcarnitines and progression of carotid artery atherosclerosis in HIV infection. ( 30649061 )
2019
37
Risk stratification of HIV infection for patients needing molecular confirmation with the Abbott 4th generation Architect System. ( 30844622 )
2019
38
HIV infection does not impact on the risk of liver complications in HCV-infected patient with advanced fibrosis, after sustained virological response with DAA. ( 30845068 )
2019
39
CXCL13 as a Biomarker of Immune Activation During Early and Chronic HIV Infection. ( 30846990 )
2019
40
High polymorphism rates in well-known T cell epitopes restricted by protective HLA alleles during HIV infection are associated with rapid disease progression in early-infected MSM in China. ( 30848362 )
2019
41
HIV infection and latency induce a unique metabolic signature in human macrophages. ( 30850623 )
2019
42
Functional proteomic atlas of HIV infection in primary human CD4+ T cells. ( 30857592 )
2019
43
Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection. ( 30862061 )
2019
44
Impact of maternal HIV infection on pregnancy outcomes in southwestern China - a hospital registry based study. ( 30868995 )
2019
45
A culturally fair test of processing speed: Construct validity, preliminary normative data, and effects of HIV infection on performance in South African adults. ( 30869933 )
2019
46
HIV infection and cerebral small vessel disease are independently associated with brain atrophy and cognitive impairment. ( 30870193 )
2019
47
Circulating (1→3)-β-D-Glucan is associated with immune activation during HIV infection. ( 30877304 )
2019
48
The influence of marital status on HIV infection in an HIV hyperendemic area of rural South Africa, 2000-2017. ( 30880581 )
2019
49
PCSK9 in HIV infection: New opportunity or red herring? ( 30890266 )
2019
50
Epigenetic Associations with Estimated Glomerular Filtration Rate (eGFR) among Men with HIV Infection. ( 30893429 )
2019
Sources

Variations for Human Immunodeficiency Virus Infectious Disease

About this section
Sources

Expression for Human Immunodeficiency Virus Infectious Disease

About this section
Search GEO for disease gene expression data for Human Immunodeficiency Virus Infectious Disease.
Sources

Pathways for Human Immunodeficiency Virus Infectious Disease

About this section

Pathways related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14.01 B2M CCL4 CCL5 CCR5 CCR6 CD28
2
ERK Signaling 65
Show member pathways
 13.85 CCL4 CCL4L1 CCL5 CCR5 CCR6 CD28
3
PEDF Induced Signaling 65
Show member pathways
 13.63 CCL4 CCL4L1 CCL5 CCR5 CCR6 CD28
4
Cytokine Signaling in Immune system 67
Show member pathways
 13.34 B2M CCL4 CCL5 CCR5 CD4 IL2
5
Akt Signaling 65
Show member pathways
 13.26 CCL4 CCL4L1 CCL5 CCR5 CCR6 CD28
6
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 13.17 CCL4 CCL4L1 CCL5 IL2 IL6 TNF
7
TNFR1 Pathway 65
Show member pathways
 12.94 CCL5 CCR5 CD4 CXCR4 IL6 TNF
8
Allograft rejection 1 38
Show member pathways
 12.87 B2M CD28 CD4 CXCR4 IL2 IL6
9
CCR5 Pathway in Macrophages 65
Show member pathways
 12.86 CCL4 CCL4L1 CCL5 CCR5 CCR6 CD4
10
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.77 CCL4 CCL4L1 CCL5 IL6 S100B TNF
11
PAK Pathway 65
Show member pathways
 12.76 CCL4 CCL4L1 CCL5 CCR5 CCR6 CD28
12
Th17 cell differentiation 38
Show member pathways
 12.59 CD28 CD4 IL2 IL6 TNF
13
Influenza A 38
Show member pathways
 12.56 CCL5 CD28 IL2 IL6 TNF
14
NF-kappaB Signaling 4
12.52 B2M CCL5 CD28 CD38 CXCR4 IL2
15
T cell receptor signaling pathway 38
Show member pathways
 12.41 CCR5 CD28 CD4 IL2 IL6 TNF
16
Selenium Micronutrient Network 1
Show member pathways
 12.33 CCL5 IL2 IL6 SERPINA3 TNF
17
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.23 CCL4 CCL4L1 CCL5 CCR5 CCR6 CXCR4
18
Human cytomegalovirus infection 38
Show member pathways
 12.16 APOBEC3G B2M CCL4 CCL4L1 CCL5 CCR5
19
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.07 CCL4 CCL5 CD4 IL2 IL6
20
Th1 Differentiation Pathway 66
Show member pathways
 12.05 CD28 CD4 IL2 IL6 TNF
21
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 66
Show member pathways
 11.97 CCL4 CCL5 CCR5 CCR6 CXCR4
22
Hematopoietic cell lineage 38
11.9 CD38 CD4 IL6 TNF
23
Jak-Stat Signaling Pathway (sino) 68
11.88 CCR5 CXCR4 IL2 IL6
24
Rheumatoid arthritis 38
11.87 CCL5 CD28 IL6 TNF
25
NF-kappa B signaling pathway 38
11.84 CCL4 CCL4L1 TNF
26
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 67
Show member pathways
 11.81 B2M CD28 CD4
27
Salmonella infection (KEGG) 38
11.8 CCL4 CCL4L1 IL6
28
Innate Lymphoid Cell Differentiation Pathways 66
11.8 CCR6 CD4 IL2 TNF
29
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.8 CD28 CD38 CD4 IL2 IL6 TNF
30
Dendritic Cells Developmental Lineage Pathway 66
11.7 CD38 CD4 IL2 IL6 TNF
31
IL12-mediated signaling events 1
Show member pathways
 11.69 B2M CCL4 CCL4L1 CCR5 CD4 IL2
32
Lung fibrosis 1
11.67 CCL4 CCL5 IL6 TNF
33
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.65 IL2 IL6 TNF
34
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.65 CCL4 CCL5 IL2 IL6 TNF
35
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.63 B2M IL2 TNF
36
B Cell Development Pathways 66
11.57 CD38 CD4 CXCR4
37
Photodynamic therapy-induced AP-1 survival signaling. 1
11.55 IL2 IL6 TNF
38
Th2 Differentiation Pathway 66
11.49 CD28 CD4 IL2
39
Interleukin-10 signaling 67
11.41 CCL4 CCL5 CCR5 IL6 TNF
40
Cytokines and Inflammatory Response 1
11.26 CD4 IL2 IL6 TNF
41
IL12 signaling mediated by STAT4 1
11.25 CD28 CD4 IL2
42
G-protein signaling_RhoB regulation pathway 23
11.18 CCL4 CCL4L1 CCL5 IL2 IL6 TNF
43
G-protein signaling_Rap2B regulation pathway 23
11.02 CCL4 CCL4L1 CCL5 IL2 IL6 TNF
Sources

GO Terms for Human Immunodeficiency Virus Infectious Disease

About this section

Cellular components related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 B2M CCL4 CCL5 IL2 IL6 ITIH4
2 extracellular space GO:0005615 9.81 B2M CCL4 CCL4L1 CCL5 IL2 IL6
3 cell surface GO:0009986 9.56 B2M CCR5 CCR6 CD28 CD38 CD4
4 external side of plasma membrane GO:0009897 9.23 B2M CCR5 CCR6 CD28 CD4 CXCR4

Biological processes related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.97 CCL5 CCR5 IL2 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 CCL4 CCL4L1 CCL5 CD4 TNF
3 cell-cell signaling GO:0007267 9.95 CCL4 CCL5 CCR5 ENPEP IL2
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.91 CD4 S100B TNF TRIM5
5 chemotaxis GO:0006935 9.91 CCL4 CCL5 CCR5 CCR6 CXCR4
6 response to virus GO:0009615 9.88 CCL4 CCL5 CXCR4 TNF
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.88 CCR5 CCR6 CD38 CXCR4 IL2
8 cellular response to interferon-gamma GO:0071346 9.87 CCL4 CCL4L1 CCL5
9 calcium-mediated signaling GO:0019722 9.87 CCR5 CCR6 CXCR4
10 cytokine-mediated signaling pathway GO:0019221 9.87 CCL4 CCL5 CCR5 CD4 IL2 IL6
11 neutrophil chemotaxis GO:0030593 9.86 CCL4 CCL4L1 CCL5
12 cellular response to interleukin-1 GO:0071347 9.85 CCL4 CCL4L1 CCL5
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 CCL5 CD28 TNF
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 CCL5 IL2 IL6
15 response to glucocorticoid GO:0051384 9.83 IL6 S100B TNF
16 cell chemotaxis GO:0060326 9.83 CCL5 CCR5 CCR6 CXCR4
17 apoptotic signaling pathway GO:0097190 9.82 CD28 CD38 TNF
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 CCL5 IL6 TNF
19 humoral immune response GO:0006959 9.8 CCR6 CD28 IL6 TNF
20 negative regulation of viral genome replication GO:0045071 9.78 APOBEC3G CCL5 TNF
21 acute-phase response GO:0006953 9.77 IL6 ITIH4 SERPINA3
22 lymphocyte chemotaxis GO:0048247 9.77 CCL4 CCL4L1 CCL5
23 chemokine-mediated signaling pathway GO:0070098 9.77 CCL4 CCL4L1 CCL5 CCR5 CCR6
24 monocyte chemotaxis GO:0002548 9.76 CCL4 CCL4L1 CCL5 IL6
25 regulation of defense response to virus by virus GO:0050690 9.75 B2M CD28 CD4
26 eosinophil chemotaxis GO:0048245 9.71 CCL4 CCL4L1 CCL5
27 negative regulation of bone resorption GO:0045779 9.7 CD38 IL6
28 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.69 CD28 CD4
29 negative regulation by host of viral transcription GO:0043922 9.69 CCL4 CCL5
30 positive regulation of immunoglobulin secretion GO:0051024 9.68 IL2 IL6
31 positive regulation of isotype switching to IgG isotypes GO:0048304 9.68 CD28 IL2
32 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
33 regulation of T cell activation GO:0050863 9.66 CCL5 CD4
34 positive regulation of T cell proliferation GO:0042102 9.65 CCL5 CD28 CD4 IL2 IL6
35 response to cytokine GO:0034097 9.64 CD38 ITIH4
36 positive regulation of natural killer cell chemotaxis GO:2000503 9.62 CCL4 CCL5
37 positive regulation of neuroinflammatory response GO:0150078 9.62 IL6 TNF
38 fusion of virus membrane with host plasma membrane GO:0019064 9.61 CCR5 CD4 CXCR4
39 entry into host cell GO:0030260 9.58 CCR5 CD4 CXCR4
40 inflammatory response GO:0006954 9.56 CCL4 CCL4L1 CCL5 CCR5 CXCR4 IL6
41 dendritic cell chemotaxis GO:0002407 9.46 CCL5 CCR5 CCR6 CXCR4
42 immune response GO:0006955 9.36 B2M CCL4 CCL5 CCR5 CCR6 CD28
43 negative regulation of macrophage apoptotic process GO:2000110 9.33 CCR5
44 G protein-coupled receptor signaling pathway GO:0007186 10.19 CCL4 CCL4L1 CCL5 CCR5 CCR6 CXCR4
45 viral process GO:0016032 10.05 APOBEC3G CCR5 CD4 CXCR4 TRIM5
46 regulation of signaling receptor activity GO:0010469 10.03 CCL4 CCL4L1 CCL5 IL2 IL6 TNF

Molecular functions related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.7 CCR5 CD4 CXCR4
2 chemokine activity GO:0008009 9.65 CCL4 CCL4L1 CCL5
3 CCR chemokine receptor binding GO:0048020 9.61 CCL4 CCL4L1 CCL5
4 chemokine binding GO:0019956 9.58 CCR5 CCR6 CXCR4
5 cytokine activity GO:0005125 9.55 CCL4 CCL5 IL2 IL6 TNF
6 C-C chemokine binding GO:0019957 9.54 CCR5 CCR6 CXCR4
7 C-C chemokine receptor activity GO:0016493 9.5 CCR5 CCR6 CXCR4
8 CCR5 chemokine receptor binding GO:0031730 9.49 CCL4 CCL5
9 CCR1 chemokine receptor binding GO:0031726 9.46 CCL4 CCL5
10 chemokine receptor activity GO:0004950 9.43 CCR5 CCR6 CXCR4
11 identical protein binding GO:0042802 9.32 APOBEC3G B2M CCL4 CCL5 CD28 CD38
12 coreceptor activity GO:0015026 9.26 CCR5 CD28 CD4 CXCR4
13 protein binding GO:0005515 10.44 APOBEC3G B2M CCL4 CCL4L1 CCL5 CCR5
Sources

Sources for Human Immunodeficiency Virus Infectious Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....