Human Immunodeficiency Virus Infectious Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: HMN014 MIFTS: 38	Human Immunodeficiency Virus Infectious Disease Categories: Infectious diseases, Immune diseases
Genes Tissues Related diseases Pathways Symptoms & Phenotypes Download Expand all tables

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Aliases & Classifications for Human Immunodeficiency Virus Infectious Disease

MalaCards integrated aliases for Human Immunodeficiency Virus Infectious Disease:

Name: Human Immunodeficiency Virus Infectious Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Human immunodeficiency virus [HIV] disease

Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

External Ids:

Disease Ontology ¹² DOID:526

ICD10 ³³ B20 B20-B20

ICD9CM ³⁵ 042 042-042.99

MeSH ⁴⁴ D015658

NCIt ⁵⁰ C3108

SNOMED-CT ⁶⁸ 123321001 186705005 187438009 more

UMLS ⁷³ C0019693

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Summaries for Human Immunodeficiency Virus Infectious Disease

Disease Ontology : ¹² A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.

MalaCards based summary : Human Immunodeficiency Virus Infectious Disease is related to acquired immunodeficiency syndrome and oral tuberculosis, and has symptoms including diarrhea, fatigue and fever. An important gene associated with Human Immunodeficiency Virus Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include t cells and breast, and related phenotypes are cellular and hematopoietic system

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Related Diseases for Human Immunodeficiency Virus Infectious Disease

Diseases related to Human Immunodeficiency Virus Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)

#	Related Disease	Score	Top Affiliating Genes
1	acquired immunodeficiency syndrome	31.4	B2M CCR2 CCR5 CD38 CD40LG IL2
2	oral tuberculosis	11.2	IL2 TNF
3	mucocutaneous leishmaniasis	11.1	CCR5 TLR9 TNF
4	yellow fever	11.0	CCL5 CCR5 TLR9
5	avoidant personality disorder	11.0	CCL5 CCR5 CXCR4
6	orofacial granulomatosis	11.0	CCL5 CCR5 TNF
7	lichen disease	11.0	CD40LG TLR9 TNF
8	plasma protein metabolism disease	11.0	CD38 CD40LG CXCR4
9	cytomegalovirus retinitis	11.0	CCR2 CCR5 TNF
10	middle ear disease	11.0	CD40LG TLR9 TNF
11	streptococcal toxic-shock syndrome	11.0	IL2 IL6 TNF
12	keratoconjunctivitis	11.0	IL2 TLR9 TNF
13	extramedullary plasmacytoma	11.0	B2M IL2 IL6
14	opportunistic mycosis	11.0	CD40LG TLR9 TNF
15	microscopic colitis	11.0	IL2 IL6 TNF
16	lacrimal apparatus disease	11.0	IL6 TLR9 TNF
17	burning mouth syndrome	11.0	IL2 IL6 TNF
18	perinatal necrotizing enterocolitis	11.0	IL6 TLR9 TNF
19	progressive multifocal leukoencephalopathy	11.0	CD40LG IL2 TNF
20	non-secretory myeloma	11.0	B2M CD38 CD40LG
21	intermediate uveitis	11.0	IL2 IL6 TNF
22	leukomalacia	10.9	IL6 TNF
23	scorpion envenomation	10.9	CCL5 IL6 TNF
24	uterine anomalies	10.9	IL6 TLR9 TNF
25	keratoconjunctivitis sicca	10.9	IL6 TLR9 TNF
26	rheumatic fever	10.9	CD40LG IL2 TNF
27	parasitic helminthiasis infectious disease	10.9	CD40LG TLR9 TNF
28	hematopoietic stem cell transplantation	10.9	IL2 IL6 TNF
29	syphilitic meningitis	10.9	CD40LG ENPEP ITIH4
30	louping ill	10.9	CD40LG ERVW-1
31	upper respiratory tract disease	10.9	CD40LG TLR9 TNF
32	autoimmune myocarditis	10.9	IL2 TNF
33	whiplash	10.9	CCL4 CCL5 CCR5
34	angioimmunoblastic lymphadenopathy with dysproteinemia	10.9	IL6 TNF
35	vernal conjunctivitis	10.9	B2M CD40LG IL2
36	murray valley encephalitis	10.9	CD40LG ERVW-1 IL2
37	prostatitis	10.9	IL2 IL6 TNF
38	post-transplant lymphoproliferative disease	10.9	B2M IL6 TNF
39	bronchial disease	10.9	CCL5 TLR9 TNF
40	paracoccidioidomycosis	10.9	IL2 IL6 TNF
41	mumps	10.9	CD40LG IL2 TNF
42	osteosclerotic myeloma	10.9	CD40LG IL6 TNF
43	leprosy 3	10.9	CD40LG IL2 TNF
44	rheumatoid lung disease	10.9	CD40LG ERVW-1 TNF
45	eye lymphoma	10.9	IL6 TLR9
46	cytomegalovirus infection	10.9	CCL5 IL6 TNF
47	hemorrhagic fever	10.9	CD40LG IL6 TNF
48	female reproductive system disease	10.9	IL6 TLR9 TNF
49	plasmodium vivax malaria	10.9	CD40LG IL6 TNF
50	macroglobulinemia	10.9	CD40LG CXCR4 IL6

Graphical network of the top 20 diseases related to Human Immunodeficiency Virus Infectious Disease:

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Symptoms & Phenotypes for Human Immunodeficiency Virus Infectious Disease

Symptoms:

¹²

• diarrhea
• fatigue
• fever
• vaginal yeast infection
• headache

• mouth sores
• muscle aches
• sore throat
• swollen lymph gl

MGI Mouse Phenotypes related to Human Immunodeficiency Virus Infectious Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.14	ITIH4 TLR9 TNF CXCR4 CCR2 IL2
2	hematopoietic system	MP:0005397	10.1	TLR9 TNF CARTPT CCL5 CCR2 IL2
3	homeostasis/metabolism	MP:0005376	10.03	TNF S100B TLR9 CARTPT CXCR4 CCR2
4	digestive/alimentary	MP:0005381	9.97	TLR9 TNF CXCR4 CCR2 IL2 CCR5
5	immune system	MP:0005387	9.97	TLR9 TNF CCL5 ENPEP CCR2 IL2
6	liver/biliary system	MP:0005370	9.5	ITIH4 TNF CCR2 IL2 CCR5 IL6
7	neoplasm	MP:0002006	9.23	TNF CCR2 IL2 CCR5 IL6 ITIH4

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Drugs & Therapeutics for Human Immunodeficiency Virus Infectious Disease

Search Clinical Trials , NIH Clinical Center for Human Immunodeficiency Virus Infectious Disease

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Genetic Tests for Human Immunodeficiency Virus Infectious Disease

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Anatomical Context for Human Immunodeficiency Virus Infectious Disease

MalaCards organs/tissues related to Human Immunodeficiency Virus Infectious Disease:

⁴¹

T Cells, Breast

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Publications for Human Immunodeficiency Virus Infectious Disease

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Genes for Human Immunodeficiency Virus Infectious Disease

Genes related to Human Immunodeficiency Virus Infectious Disease (0 elite genes):

(show all 32)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TLR9	Toll Like Receptor 9	Protein Coding	20.32	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CCR5	C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)	Protein Coding	19.93	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	ITIH4	Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 4	Protein Coding	19.63	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	CARTPT	CART Prepropeptide	Protein Coding	19.3	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	18.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	IL2	Interleukin 2	Protein Coding	18.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	APOBEC3G	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3G	Protein Coding	18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	S100B	S100 Calcium Binding Protein B	Protein Coding	17.82	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	CD38	CD38 Molecule	Protein Coding	17.81	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	TNF	Tumor Necrosis Factor	Protein Coding	17.67	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	B2M	Beta-2-Microglobulin	Protein Coding	17.48	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	17.45	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	CD40LG	CD40 Ligand	Protein Coding	17.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	17.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	IL6	Interleukin 6	Protein Coding	17.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	ACOT1	Acyl-CoA Thioesterase 1	Protein Coding	17.18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	ERVW-1	Endogenous Retrovirus Group W Member 1, Envelope	Protein Coding	8.62	DISEASES inferred ¹⁵
18	ENPEP	Glutamyl Aminopeptidase	Protein Coding	7.6	DISEASES inferred ¹⁵
19	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	7.45	DISEASES inferred ¹⁵
20	CCL4L1	C-C Motif Chemokine Ligand 4 Like 1	Protein Coding	7.42	DISEASES inferred ¹⁵
21	CD79A	CD79a Molecule	Protein Coding	7.16	DISEASES inferred ¹⁵
22	TRIM5	Tripartite Motif Containing 5	Protein Coding	7.11	DISEASES inferred ¹⁵
23	IFNG	Interferon Gamma	Protein Coding	7.1	DISEASES inferred ¹⁵
24	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	7.07	DISEASES inferred ¹⁵
25	SRY	Sex Determining Region Y	Protein Coding	7.04	DISEASES inferred ¹⁵
26	CD4	CD4 Molecule	Protein Coding	7.03	DISEASES inferred ¹⁵
27	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	7.03	DISEASES inferred ¹⁵
28	IFNA1	Interferon Alpha 1	Protein Coding	6.99	DISEASES inferred ¹⁵
29	BST2	Bone Marrow Stromal Cell Antigen 2	Protein Coding	6.91	DISEASES inferred ¹⁵
30	SCD5	Stearoyl-CoA Desaturase 5	Protein Coding	6.89	DISEASES inferred ¹⁵
31	IL10	Interleukin 10	Protein Coding	6.88	DISEASES inferred ¹⁵
32	RBM8A	RNA Binding Motif Protein 8A	Protein Coding	6.87	DISEASES inferred ¹⁵

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Variations for Human Immunodeficiency Virus Infectious Disease

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Expression for Human Immunodeficiency Virus Infectious Disease

Search GEO for disease gene expression data for Human Immunodeficiency Virus Infectious Disease.

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Pathways for Human Immunodeficiency Virus Infectious Disease

Pathways related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 38)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.01	B2M CCL4 CCL5 CCR2 CCR5 CD40LG
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.82	CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
3	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.62	CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
4	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.27	B2M CCL4 CCL5 CCR2 CCR5 CD40LG
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.14	CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.13	CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
7	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.92	CCL4 CCL4L1 CCL5 IL2 IL6 TLR9
8	CCR5 Pathway in Macrophages ⁶⁴ Show member pathways Androgen Signaling ⁶⁴ Chemokine Signaling ⁶⁴ Chemokine signaling pathway ³⁷	12.84	CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
9	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ DR3 Signaling ⁶⁴ Fas Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.83	CCL5 CCR5 CXCR4 IL6 TNF
10	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.83	B2M CD40LG CXCR4 IL2 IL6 TNF
11	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.75	CCL5 IL2 IL6 TLR9 TNF
12	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ³⁷ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of RIG-I/MDA5 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁷ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁵	12.69	CCL4 CCL4L1 CCL5 IL6 S100B TNF
13	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.65	CD40LG IL2 IL6 TLR9 TNF
14	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.36	CCR5 CD40LG IL2 IL6 TNF
15	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.28	CCL5 IL2 IL6 TNF
16	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ IL-6-type cytokine receptor ligand interactions ⁶⁶ Interleukin-6 family signaling ⁶⁶ Interleukin-6 signaling ⁶⁶ Th17 Differentiation Pathway ⁶⁵	12.21	IL2 IL6 TLR9 TNF
17	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.16	IL2 IL6 TLR9 TNF
18	Spinal Cord Injury ¹	11.97	CCR2 IL2 IL6 TNF
19	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.94	CD38 IL2 IL6 TNF
20	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁵ Show member pathways Chemokine receptors bind chemokines ⁶⁶	11.9	CCL4 CCL5 CCR2 CCR5 CXCR4
21	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.86	B2M CCL4 CCL4L1 CCR5 IL2
22	Hematopoietic cell lineage ³⁷	11.84	CD38 IL6 TNF
23	NF-kappa B signaling pathway ³⁷	11.82	CCL4 CCL4L1 CD40LG TNF
24	Jak-Stat Signaling Pathway ⁶⁷	11.82	CCR2 CCR5 CXCR4 IL2 IL6
25	Rheumatoid arthritis ³⁷	11.8	CCL5 IL6 TNF
26	NF-kappaB Signaling ⁴	11.79	B2M CCL5 CCR2 CD38 CD40LG CXCR4
27	Salmonella infection (KEGG) ³⁷	11.78	CCL4 CCL4L1 IL6
28	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.72	CD40LG IL2 TNF
29	Downstream signaling in naive CD8+ T cells ¹ Show member pathways Ras signaling in the CD4+ TCR pathway ¹	11.6	B2M IL2 TNF
30	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.6	CD40LG IL2 IL6 TNF
31	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.59	CD38 IL2 IL6 TLR9 TNF
32	B Cell Development Pathways ⁶⁵	11.53	CD38 CD40LG CXCR4
33	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.5	IL2 IL6 TNF
34	Malaria ³⁷	11.45	CD40LG IL6 TLR9 TNF
35	Lung fibrosis ¹	11.35	CCL4 CCL5 CCR2 IL6 TNF
36	African trypanosomiasis ³⁷	11.32	IL6 TLR9 TNF
37	Cytokines and Inflammatory Response ¹	11.22	IL2 IL6 TNF
38	Interleukin-10 signaling ⁶⁶	11.12	CCL4 CCL5 CCR2 CCR5 IL6 TNF

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GO Terms for Human Immunodeficiency Virus Infectious Disease

Cellular components related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.9	B2M CARTPT CCL4 CCL5 CD40LG IL2
2	cell surface	GO:0009986	9.73	B2M CCR5 CD38 CD40LG CXCR4 TNF
3	external side of plasma membrane	GO:0009897	9.43	B2M CCR2 CCR5 CD40LG ENPEP TNF
4	extracellular space	GO:0005615	9.36	B2M CARTPT CCL4 CCL4L1 CCL5 CD40LG

Biological processes related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 45)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.98	CCL4 CCL4L1 CCL5 TNF
2	cell-cell signaling	GO:0007267	9.97	CARTPT CCL4 CCL5 CCR5 ENPEP IL2
3	regulation of signaling receptor activity	GO:0010469	9.97	CARTPT CCL4 CCL4L1 CCL5 CD40LG IL2
4	cytokine-mediated signaling pathway	GO:0019221	9.95	CCL4 CCL5 CCR2 CCR5 IL2 IL6
5	chemotaxis	GO:0006935	9.91	CCL4 CCL5 CCR2 CCR5 CXCR4
6	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.89	CD40LG IL6 TLR9 TNF
7	cellular response to interferon-gamma	GO:0071346	9.87	CCL4 CCL4L1 CCL5
8	response to virus	GO:0009615	9.86	CCL4 CCL5 CXCR4 TNF
9	cellular response to interleukin-1	GO:0071347	9.85	CCL4 CCL4L1 CCL5
10	regulation of insulin secretion	GO:0050796	9.85	CARTPT CCL5 TNF
11	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.85	CCR2 CCR5 CD38 CXCR4 IL2
12	neutrophil chemotaxis	GO:0030593	9.84	CCL4 CCL4L1 CCL5
13	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.84	CCL5 IL2 IL6
14	response to glucocorticoid	GO:0051384	9.83	IL6 S100B TNF
15	response to cytokine	GO:0034097	9.83	CCL5 CD38 ITIH4
16	positive regulation of T cell proliferation	GO:0042102	9.83	CCL5 CD40LG IL2 IL6
17	positive regulation of inflammatory response	GO:0050729	9.83	CCL4 CCL4L1 CCR2 IL2 TLR9
18	humoral immune response	GO:0006959	9.82	CCR2 IL6 TNF
19	positive regulation of smooth muscle cell proliferation	GO:0048661	9.82	CCL5 IL6 TNF
20	immune response	GO:0006955	9.81	B2M CCL4 CCL5 CCR2 CCR5 CD40LG
21	positive regulation of interleukin-6 production	GO:0032755	9.8	IL6 TLR9 TNF
22	positive regulation of interferon-gamma production	GO:0032729	9.79	CCR2 IL2 TNF
23	positive regulation of B cell proliferation	GO:0030890	9.79	CD38 IL2 TLR9
24	negative regulation of viral genome replication	GO:0045071	9.78	APOBEC3G CCL5 TNF
25	lymphocyte chemotaxis	GO:0048247	9.76	CCL4 CCL4L1 CCL5
26	eosinophil chemotaxis	GO:0048245	9.72	CCL4 CCL4L1 CCL5
27	positive regulation of chemokine production	GO:0032722	9.71	IL6 TLR9 TNF
28	response to molecule of bacterial origin	GO:0002237	9.69	B2M TLR9
29	positive regulation of immunoglobulin secretion	GO:0051024	9.69	IL2 IL6
30	negative regulation by host of viral transcription	GO:0043922	9.68	CCL4 CCL5
31	positive regulation of T cell chemotaxis	GO:0010820	9.68	CCL5 CCR2
32	negative regulation of lipid storage	GO:0010888	9.67	IL6 TNF
33	fusion of virus membrane with host plasma membrane	GO:0019064	9.65	CCR5 CXCR4
34	negative regulation of bone resorption	GO:0045779	9.65	CARTPT CD38 IL6
35	monocyte chemotaxis	GO:0002548	9.65	CCL4 CCL4L1 CCL5 CCR2 IL6
36	positive regulation of natural killer cell chemotaxis	GO:2000503	9.64	CCL4 CCL5
37	negative regulation of macrophage apoptotic process	GO:2000110	9.63	CCL5 CCR5
38	regulation of immunoglobulin secretion	GO:0051023	9.62	CD40LG TNF
39	dendritic cell chemotaxis	GO:0002407	9.62	CCL5 CCR2 CCR5 CXCR4
40	entry into host cell	GO:0030260	9.6	CCR5 CXCR4
41	regulation of vascular endothelial growth factor production	GO:0010574	9.58	CCR2 IL6
42	chemokine-mediated signaling pathway	GO:0070098	9.43	CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
43	inflammatory response	GO:0006954	9.32	CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
44	G-protein coupled receptor signaling pathway	GO:0007186	10.17	CARTPT CCL4 CCL4L1 CCL5 CCR2 CCR5
45	MAPK cascade	GO:0000165	10	CCL5 CCR5 IL2 TNF

Molecular functions related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.91	APOBEC3G B2M CCL4 CCL5 CD38 S100B
2	chemokine activity	GO:0008009	9.5	CCL4 CCL4L1 CCL5
3	C-C chemokine receptor activity	GO:0016493	9.46	CCR2 CCR5
4	C-C chemokine binding	GO:0019957	9.43	CCR5 CXCR4
5	CCR5 chemokine receptor binding	GO:0031730	9.4	CCL4 CCL5
6	CCR chemokine receptor binding	GO:0048020	9.33	CCL4 CCL4L1 CCL5
7	CCR1 chemokine receptor binding	GO:0031726	9.26	CCL4 CCL5
8	chemokine receptor activity	GO:0004950	9.13	CCR2 CCR5 CXCR4
9	cytokine activity	GO:0005125	9.1	CCL4 CCL5 CD40LG IL2 IL6 TNF

Sources

Sources for Human Immunodeficiency Virus Infectious Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia