MCID: HMN014
MIFTS: 38

Human Immunodeficiency Virus Infectious Disease

Categories: Infectious diseases, Immune diseases

Aliases & Classifications for Human Immunodeficiency Virus Infectious Disease

MalaCards integrated aliases for Human Immunodeficiency Virus Infectious Disease:

Name: Human Immunodeficiency Virus Infectious Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:526
ICD10 33 B20 B20-B20
ICD9CM 35 042 042-042.99
MeSH 44 D015658
NCIt 50 C3108
UMLS 73 C0019693

Summaries for Human Immunodeficiency Virus Infectious Disease

Disease Ontology : 12 A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands.

MalaCards based summary : Human Immunodeficiency Virus Infectious Disease is related to acquired immunodeficiency syndrome and oral tuberculosis, and has symptoms including diarrhea, fatigue and fever. An important gene associated with Human Immunodeficiency Virus Infectious Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include t cells and breast, and related phenotypes are cellular and hematopoietic system

Related Diseases for Human Immunodeficiency Virus Infectious Disease

Diseases related to Human Immunodeficiency Virus Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 acquired immunodeficiency syndrome 31.4 B2M CCR2 CCR5 CD38 CD40LG IL2
2 oral tuberculosis 11.2 IL2 TNF
3 mucocutaneous leishmaniasis 11.1 CCR5 TLR9 TNF
4 yellow fever 11.0 CCL5 CCR5 TLR9
5 avoidant personality disorder 11.0 CCL5 CCR5 CXCR4
6 orofacial granulomatosis 11.0 CCL5 CCR5 TNF
7 lichen disease 11.0 CD40LG TLR9 TNF
8 plasma protein metabolism disease 11.0 CD38 CD40LG CXCR4
9 cytomegalovirus retinitis 11.0 CCR2 CCR5 TNF
10 middle ear disease 11.0 CD40LG TLR9 TNF
11 streptococcal toxic-shock syndrome 11.0 IL2 IL6 TNF
12 keratoconjunctivitis 11.0 IL2 TLR9 TNF
13 extramedullary plasmacytoma 11.0 B2M IL2 IL6
14 opportunistic mycosis 11.0 CD40LG TLR9 TNF
15 microscopic colitis 11.0 IL2 IL6 TNF
16 lacrimal apparatus disease 11.0 IL6 TLR9 TNF
17 burning mouth syndrome 11.0 IL2 IL6 TNF
18 perinatal necrotizing enterocolitis 11.0 IL6 TLR9 TNF
19 progressive multifocal leukoencephalopathy 11.0 CD40LG IL2 TNF
20 non-secretory myeloma 11.0 B2M CD38 CD40LG
21 intermediate uveitis 11.0 IL2 IL6 TNF
22 leukomalacia 10.9 IL6 TNF
23 scorpion envenomation 10.9 CCL5 IL6 TNF
24 uterine anomalies 10.9 IL6 TLR9 TNF
25 keratoconjunctivitis sicca 10.9 IL6 TLR9 TNF
26 rheumatic fever 10.9 CD40LG IL2 TNF
27 parasitic helminthiasis infectious disease 10.9 CD40LG TLR9 TNF
28 hematopoietic stem cell transplantation 10.9 IL2 IL6 TNF
29 syphilitic meningitis 10.9 CD40LG ENPEP ITIH4
30 louping ill 10.9 CD40LG ERVW-1
31 upper respiratory tract disease 10.9 CD40LG TLR9 TNF
32 autoimmune myocarditis 10.9 IL2 TNF
33 whiplash 10.9 CCL4 CCL5 CCR5
34 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL6 TNF
35 vernal conjunctivitis 10.9 B2M CD40LG IL2
36 murray valley encephalitis 10.9 CD40LG ERVW-1 IL2
37 prostatitis 10.9 IL2 IL6 TNF
38 post-transplant lymphoproliferative disease 10.9 B2M IL6 TNF
39 bronchial disease 10.9 CCL5 TLR9 TNF
40 paracoccidioidomycosis 10.9 IL2 IL6 TNF
41 mumps 10.9 CD40LG IL2 TNF
42 osteosclerotic myeloma 10.9 CD40LG IL6 TNF
43 leprosy 3 10.9 CD40LG IL2 TNF
44 rheumatoid lung disease 10.9 CD40LG ERVW-1 TNF
45 eye lymphoma 10.9 IL6 TLR9
46 cytomegalovirus infection 10.9 CCL5 IL6 TNF
47 hemorrhagic fever 10.9 CD40LG IL6 TNF
48 female reproductive system disease 10.9 IL6 TLR9 TNF
49 plasmodium vivax malaria 10.9 CD40LG IL6 TNF
50 macroglobulinemia 10.9 CD40LG CXCR4 IL6

Graphical network of the top 20 diseases related to Human Immunodeficiency Virus Infectious Disease:



Diseases related to Human Immunodeficiency Virus Infectious Disease

Symptoms & Phenotypes for Human Immunodeficiency Virus Infectious Disease

Symptoms:

12
  • diarrhea
  • fatigue
  • fever
  • vaginal yeast infection
  • headache
  • mouth sores
  • muscle aches
  • sore throat
  • swollen lymph gl

MGI Mouse Phenotypes related to Human Immunodeficiency Virus Infectious Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 ITIH4 TLR9 TNF CXCR4 CCR2 IL2
2 hematopoietic system MP:0005397 10.1 TLR9 TNF CARTPT CCL5 CCR2 IL2
3 homeostasis/metabolism MP:0005376 10.03 TNF S100B TLR9 CARTPT CXCR4 CCR2
4 digestive/alimentary MP:0005381 9.97 TLR9 TNF CXCR4 CCR2 IL2 CCR5
5 immune system MP:0005387 9.97 TLR9 TNF CCL5 ENPEP CCR2 IL2
6 liver/biliary system MP:0005370 9.5 ITIH4 TNF CCR2 IL2 CCR5 IL6
7 neoplasm MP:0002006 9.23 TNF CCR2 IL2 CCR5 IL6 ITIH4

Drugs & Therapeutics for Human Immunodeficiency Virus Infectious Disease

Search Clinical Trials , NIH Clinical Center for Human Immunodeficiency Virus Infectious Disease

Genetic Tests for Human Immunodeficiency Virus Infectious Disease

Anatomical Context for Human Immunodeficiency Virus Infectious Disease

MalaCards organs/tissues related to Human Immunodeficiency Virus Infectious Disease:

41
T Cells, Breast

Publications for Human Immunodeficiency Virus Infectious Disease

Variations for Human Immunodeficiency Virus Infectious Disease

Expression for Human Immunodeficiency Virus Infectious Disease

Search GEO for disease gene expression data for Human Immunodeficiency Virus Infectious Disease.

Pathways for Human Immunodeficiency Virus Infectious Disease

Pathways related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 B2M CCL4 CCL5 CCR2 CCR5 CD40LG
2
Show member pathways
13.82 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
3
Show member pathways
13.62 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
4
Show member pathways
13.27 B2M CCL4 CCL5 CCR2 CCR5 CD40LG
5
Show member pathways
13.14 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
6
Show member pathways
13.13 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
7
Show member pathways
12.92 CCL4 CCL4L1 CCL5 IL2 IL6 TLR9
8
Show member pathways
12.84 CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
9
Show member pathways
12.83 CCL5 CCR5 CXCR4 IL6 TNF
10
Show member pathways
12.83 B2M CD40LG CXCR4 IL2 IL6 TNF
11
Show member pathways
12.75 CCL5 IL2 IL6 TLR9 TNF
12
Show member pathways
12.69 CCL4 CCL4L1 CCL5 IL6 S100B TNF
13
Show member pathways
12.65 CD40LG IL2 IL6 TLR9 TNF
14
Show member pathways
12.36 CCR5 CD40LG IL2 IL6 TNF
15
Show member pathways
12.28 CCL5 IL2 IL6 TNF
16
Show member pathways
12.21 IL2 IL6 TLR9 TNF
17
Show member pathways
12.16 IL2 IL6 TLR9 TNF
18 11.97 CCR2 IL2 IL6 TNF
19 11.94 CD38 IL2 IL6 TNF
20
Show member pathways
11.9 CCL4 CCL5 CCR2 CCR5 CXCR4
21
Show member pathways
11.86 B2M CCL4 CCL4L1 CCR5 IL2
22 11.84 CD38 IL6 TNF
23 11.82 CCL4 CCL4L1 CD40LG TNF
24 11.82 CCR2 CCR5 CXCR4 IL2 IL6
25 11.8 CCL5 IL6 TNF
26 11.79 B2M CCL5 CCR2 CD38 CD40LG CXCR4
27 11.78 CCL4 CCL4L1 IL6
28
Show member pathways
11.72 CD40LG IL2 TNF
29
Show member pathways
11.6 B2M IL2 TNF
30
Show member pathways
11.6 CD40LG IL2 IL6 TNF
31 11.59 CD38 IL2 IL6 TLR9 TNF
32 11.53 CD38 CD40LG CXCR4
33 11.5 IL2 IL6 TNF
34 11.45 CD40LG IL6 TLR9 TNF
35 11.35 CCL4 CCL5 CCR2 IL6 TNF
36 11.32 IL6 TLR9 TNF
37 11.22 IL2 IL6 TNF
38 11.12 CCL4 CCL5 CCR2 CCR5 IL6 TNF

GO Terms for Human Immunodeficiency Virus Infectious Disease

Cellular components related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 B2M CARTPT CCL4 CCL5 CD40LG IL2
2 cell surface GO:0009986 9.73 B2M CCR5 CD38 CD40LG CXCR4 TNF
3 external side of plasma membrane GO:0009897 9.43 B2M CCR2 CCR5 CD40LG ENPEP TNF
4 extracellular space GO:0005615 9.36 B2M CARTPT CCL4 CCL4L1 CCL5 CD40LG

Biological processes related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 CCL4 CCL4L1 CCL5 TNF
2 cell-cell signaling GO:0007267 9.97 CARTPT CCL4 CCL5 CCR5 ENPEP IL2
3 regulation of signaling receptor activity GO:0010469 9.97 CARTPT CCL4 CCL4L1 CCL5 CD40LG IL2
4 cytokine-mediated signaling pathway GO:0019221 9.95 CCL4 CCL5 CCR2 CCR5 IL2 IL6
5 chemotaxis GO:0006935 9.91 CCL4 CCL5 CCR2 CCR5 CXCR4
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 CD40LG IL6 TLR9 TNF
7 cellular response to interferon-gamma GO:0071346 9.87 CCL4 CCL4L1 CCL5
8 response to virus GO:0009615 9.86 CCL4 CCL5 CXCR4 TNF
9 cellular response to interleukin-1 GO:0071347 9.85 CCL4 CCL4L1 CCL5
10 regulation of insulin secretion GO:0050796 9.85 CARTPT CCL5 TNF
11 positive regulation of cytosolic calcium ion concentration GO:0007204 9.85 CCR2 CCR5 CD38 CXCR4 IL2
12 neutrophil chemotaxis GO:0030593 9.84 CCL4 CCL4L1 CCL5
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 CCL5 IL2 IL6
14 response to glucocorticoid GO:0051384 9.83 IL6 S100B TNF
15 response to cytokine GO:0034097 9.83 CCL5 CD38 ITIH4
16 positive regulation of T cell proliferation GO:0042102 9.83 CCL5 CD40LG IL2 IL6
17 positive regulation of inflammatory response GO:0050729 9.83 CCL4 CCL4L1 CCR2 IL2 TLR9
18 humoral immune response GO:0006959 9.82 CCR2 IL6 TNF
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 CCL5 IL6 TNF
20 immune response GO:0006955 9.81 B2M CCL4 CCL5 CCR2 CCR5 CD40LG
21 positive regulation of interleukin-6 production GO:0032755 9.8 IL6 TLR9 TNF
22 positive regulation of interferon-gamma production GO:0032729 9.79 CCR2 IL2 TNF
23 positive regulation of B cell proliferation GO:0030890 9.79 CD38 IL2 TLR9
24 negative regulation of viral genome replication GO:0045071 9.78 APOBEC3G CCL5 TNF
25 lymphocyte chemotaxis GO:0048247 9.76 CCL4 CCL4L1 CCL5
26 eosinophil chemotaxis GO:0048245 9.72 CCL4 CCL4L1 CCL5
27 positive regulation of chemokine production GO:0032722 9.71 IL6 TLR9 TNF
28 response to molecule of bacterial origin GO:0002237 9.69 B2M TLR9
29 positive regulation of immunoglobulin secretion GO:0051024 9.69 IL2 IL6
30 negative regulation by host of viral transcription GO:0043922 9.68 CCL4 CCL5
31 positive regulation of T cell chemotaxis GO:0010820 9.68 CCL5 CCR2
32 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
33 fusion of virus membrane with host plasma membrane GO:0019064 9.65 CCR5 CXCR4
34 negative regulation of bone resorption GO:0045779 9.65 CARTPT CD38 IL6
35 monocyte chemotaxis GO:0002548 9.65 CCL4 CCL4L1 CCL5 CCR2 IL6
36 positive regulation of natural killer cell chemotaxis GO:2000503 9.64 CCL4 CCL5
37 negative regulation of macrophage apoptotic process GO:2000110 9.63 CCL5 CCR5
38 regulation of immunoglobulin secretion GO:0051023 9.62 CD40LG TNF
39 dendritic cell chemotaxis GO:0002407 9.62 CCL5 CCR2 CCR5 CXCR4
40 entry into host cell GO:0030260 9.6 CCR5 CXCR4
41 regulation of vascular endothelial growth factor production GO:0010574 9.58 CCR2 IL6
42 chemokine-mediated signaling pathway GO:0070098 9.43 CCL4 CCL4L1 CCL5 CCR2 CCR5 CXCR4
43 inflammatory response GO:0006954 9.32 CCL4 CCL4L1 CCL5 CCR2 CCR5 CD40LG
44 G-protein coupled receptor signaling pathway GO:0007186 10.17 CARTPT CCL4 CCL4L1 CCL5 CCR2 CCR5
45 MAPK cascade GO:0000165 10 CCL5 CCR5 IL2 TNF

Molecular functions related to Human Immunodeficiency Virus Infectious Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 APOBEC3G B2M CCL4 CCL5 CD38 S100B
2 chemokine activity GO:0008009 9.5 CCL4 CCL4L1 CCL5
3 C-C chemokine receptor activity GO:0016493 9.46 CCR2 CCR5
4 C-C chemokine binding GO:0019957 9.43 CCR5 CXCR4
5 CCR5 chemokine receptor binding GO:0031730 9.4 CCL4 CCL5
6 CCR chemokine receptor binding GO:0048020 9.33 CCL4 CCL4L1 CCL5
7 CCR1 chemokine receptor binding GO:0031726 9.26 CCL4 CCL5
8 chemokine receptor activity GO:0004950 9.13 CCR2 CCR5 CXCR4
9 cytokine activity GO:0005125 9.1 CCL4 CCL5 CD40LG IL2 IL6 TNF

Sources for Human Immunodeficiency Virus Infectious Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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